Cellular Senescence in Disease

Cellular Senescence in Disease
Author: Manuel Serrano,Daniel Munoz-Espin
Publsiher: Academic Press
Total Pages: 472
Release: 2021-11-27
ISBN 10: 0128225157
ISBN 13: 9780128225158
Language: EN, FR, DE, ES & NL

Cellular Senescence in Disease Book Review:

Research in the field of senescence has boomed recently due to the gradual realization that senescent cells are associated with a significant number of diseases. The genetic or pharmacological elimination of senescent cells can cause widespread benefits and improves outcomes for most of those diseases. Cellular Senescence in Diseases presents an updated review of the role of cellular senescence in multiple pathologies. Focus is given to those diseases where the implication of senescence has been more extensively documented, such as (cancer, lung and liver diseases, diabetes, Neurodegenerative diseases and others). The Editors recruited a group of worldwide experts in each individual pathology to review the role of cellular senescence in each one of them, aiming at identifying potential therapeutic pathways. The first two chapters provide an overview of the cellular senescence principles. Next, the chapters are divided into specific diseases. Cancer, including premalignant lesions (OIS), Advanced disease (TIS), and Metastasis are covered. The following condition covered is Lund diseases, including IPF, COPD, and Pulmonary Hypertension. Next Liver Diseases are covered, including Fibrosis and Cirrhosis, and Fatty liver disease. Next there is coverage for Kidney implications, including fibrosis and transplantation. Vascular diseases are covered next including infarction and hear fibrosis, and atherosclerosis. Both diabetes types 1 and 2 are covered next. Following chapters cover Obesity, Sarcopenia, and Bone and Cartilage disorders, respectively. Neurodegenerative diseases are covered next, focusing on Alzheimer and Parkinson. The next chapter discusses accumulation of senescent cell in tissues during aging. The two final chapters cover current developments and conclusions. Cellular Senescence in Diseases is designed for researchers and clinicians with a focus on the cellular mechanisms of diseases. All chapters cover current experimental therapeutic approaches to eliminate or cancel the pathological effects of senescent cells. Pharmaceutical scientists may also benefit from the contents of the book in the exploration of novel therapeutic opportunities. Provides a thorough introduction to Cellular Senescence Covers all major pathologies for which cellular senescence has shown evidence of involvement Focuses on possible therapeutic pathways Edited and authored by worldwide experts

Cellular Senescence in Health Disease and Aging

Cellular Senescence in Health  Disease and Aging
Author: Markus Riessland
Publsiher: Mdpi AG
Total Pages: 112
Release: 2021-11-08
ISBN 10: 9783036521756
ISBN 13: 3036521755
Language: EN, FR, DE, ES & NL

Cellular Senescence in Health Disease and Aging Book Review:

Dear Colleagues, When Hayflick and Moorhead coined the term "cellular senescence" (CS) almost 60 years ago, this phenomenon was understood as a mechanism, usually induced by activation of the DNA-repair machinery, to prevent uncontrolled proliferation. Meanwhile, additional beneficial roles for CS have been identified, such as embryonic development and wound healing. The senescence associated secretory phenotype (SASP) activated in most senescent cells (SC) signals to the immune system "come here and remove me". In organisms with young and functional immune systems, occurring SC are usually detected and removed. If SC remain in the tissue expressing the SASP, this will cause not just a damaging local inflammation but can also induce remodeling and regeneration of the surrounding tissue as well as spreading of senescence. Old organisms show reduced regenerative potential and immune function which leads to accumulation of SC. Accordingly, accumulation of SC was observed in tissues of aged individuals, but importantly also in the context of age-related disorders, neurodegenerative, or cardiovascular diseases and others. Because of its detrimental effect of the surrounding tissue, accumulation of SC is not just a consequence, but can rather been understood as a major driver of aging. In line with this, recent studies described that removal of SC showed beneficial effects on healthspan and lifespan. This exciting research led to the discovery of "senolytics", drugs which can kill SC. Given the heterogeneity of cell types that show senescence-like phenotypes, including heart muscle and post-mitotic neuronal cells, further research is required to unravel the molecular background that renders a cell type vulnerable to senesce. Additionally, it will be important to understand how senescence is cell type-specifically induced and which molecules serve as drug targets to prevent senescence and its spreading, or actively kill SC. This special issue will shed light on the molecular pathways of CS and inflammaging and on possible strategies to interfere with these processes. Dr. Markus Riessland Guest Editor

The Role of Cellular Senescence in Health and Disease

The Role of Cellular Senescence in Health and Disease
Author: Isabel Varela-Nieto,Ignacio Palmero,Vassilis G. Gorgoulis
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2022-03-09
ISBN 10: 2889746267
ISBN 13: 9782889746262
Language: EN, FR, DE, ES & NL

The Role of Cellular Senescence in Health and Disease Book Review:

Senolytics in Disease Ageing and Longevity

Senolytics in Disease  Ageing and Longevity
Author: Daniel Muñoz-Espin,Marco Demaria
Publsiher: Springer Nature
Total Pages: 222
Release: 2020-04-27
ISBN 10: 3030449033
ISBN 13: 9783030449032
Language: EN, FR, DE, ES & NL

Senolytics in Disease Ageing and Longevity Book Review:

This book offers comprehensive information on the new and rapidly evolving science of identifying and targeting senescent cells, and on the exciting prospect of new diagnostic and therapeutic opportunities for stopping, and even reversing, the progression of disease and the deterioration of the human body due to ageing. According to recent United Nations data, by 2050 one in six people worldwide will be older than age 65, with peaks rising to one in four people in Europe and North America. Remarkably, the number of persons aged 80 years or older is expected to triple, from 143 million in 2019 to 426 million in 2050. First documented in the 1960s, the concept of cellular senescence as an underlying cause of ageing has been established in the course of the last decade. Using genetically engineered mouse models, researchers have demonstrated that the selective elimination of senescent cells can block and even reverse a number of age-related dysfunctions and pathologies, promoting both better health and longer life in the elderly. These include cardiovascular diseases; neurological disorders; type 1 and type 2 diabetes; inflammatory diseases; fibrosis; geriatric syndromes; chronic diseases resulting in organ dysfunction; the integrity of the musculoskeletal system; and cancer. Some senolytic agents have already progressed into trials. These include UBX0101 for the treatment of osteoarthritis (now in phase II), a cocktail of dasatinib and quercetin for the management of idiopathic pulmonary fibrosis and chronic kidney disease, and ABT-263 in combination with senescence-inducing chemotherapies for the treatment of advanced solid tumours. In addition, the book discusses pathways to early phase clinical trials and translational approaches in medicine and ageing, highlighting new opportunities as well as current limitations, challenges and alternatives. Given its scope, it will benefit a broad audience of advanced educators, researchers, graduate students and practitioners.

Innovative Medicine

Innovative Medicine
Author: Kazuwa Nakao,Nagahiro Minato,Shinji Uemoto
Publsiher: Springer
Total Pages: 339
Release: 2015-10-13
ISBN 10: 4431556516
ISBN 13: 9784431556510
Language: EN, FR, DE, ES & NL

Innovative Medicine Book Review:

This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

Skin Aging

Skin Aging
Author: Barbara A. Gilchrest,Jean Krutmann
Publsiher: Springer Science & Business Media
Total Pages: 198
Release: 2006-04-20
ISBN 10: 3540329536
ISBN 13: 9783540329534
Language: EN, FR, DE, ES & NL

Skin Aging Book Review:

The topic of skin aging is of growing importance to all working in the field of dermatology, aesthetic medicine and cosmetic medicine. Two internationally well-known and leading experts in the field present a comprehensive state-of-the-art review on all aspects of skin aging. With its clear, concise and reader-friendly format this book has all the potential to become the Bible of skin aging. Every specialist interested in dermatology, aesthetic medicine, cosmetic science, cutaneous biology and aging research will find indispensable information of great value for his or her daily work.

Senescence and Senescence Related Disorders

Senescence and Senescence Related Disorders
Author: Wang Zhiwei,Hiroyuki Inuzuka
Publsiher: BoD – Books on Demand
Total Pages: 160
Release: 2013-02-20
ISBN 10: 9535109979
ISBN 13: 9789535109976
Language: EN, FR, DE, ES & NL

Senescence and Senescence Related Disorders Book Review:

Senescence is a biological process that causes a progressive deterioration of structure and function of all organs chronologically. Recent studies have revealed the detailed molecular mechanisms of senescence using cell culture system and experimental organisms. It is thought that senescence is a potential cause for the development of various age-related disorders such as cancer, cardiovascular and neurodegenerative disorders. This book discusses in detail senescence and its related diseases by distinguished researchers and practicing clinicians. The cumulative knowledge from the studies could lead to developing new approaches for anti-senescence interventions.

Stem Cells and Aging

Stem Cells and Aging
Author: Surajit Pathak,Antara Banerjee
Publsiher: Academic Press
Total Pages: 320
Release: 2021-03-17
ISBN 10: 0128204133
ISBN 13: 9780128204139
Language: EN, FR, DE, ES & NL

Stem Cells and Aging Book Review:

Stem Cells and Aging covers what is known about the effect of time and age on the basic units of life, which are the corresponding tissue-specific or adult stem cells. Even though the concept of stem cells was introduced nearly a century ago by Alexander Maximow, modern stem-cell research began in 1963 when James Till, Ernest McCullough and Lou Siminovitch established assays to detect hematopoietic stem cells. In fact, given the importance of the aging-associated diseases, scientists have developed a keen interest in understanding the aging process as they attempt to define the role of dysfunctional stem cells in the aging process. With an aging population worldwide, understanding these age-related stem cell changes at a basic biology level and at the level of their influences for regenerative medicine is of interest and importance. There is increasing evidence that the aging process can have much adverse effects on stem cells. In the modern era, one of the emerging fields in treating human diseases is stem cell research, as stem cells have the remarkable potential to treat a wide range of diseases. Nevertheless, understanding the molecular mechanism involved in aging and deterioration of stem cell function is crucial in developing effective new therapies for aging. Serves as an ideal reference to guide investigators toward valuable answers to the problems of our aging population Addresses the effect of time and age on human stem cells Includes chapters from contributors exploring the biology of stem cell aging around the globe

Frailty

Frailty
Author: R.A. Fielding
Publsiher: Unknown
Total Pages: 124
Release: 2015
ISBN 10: 9783318054774
ISBN 13: 3318054771
Language: EN, FR, DE, ES & NL

Frailty Book Review:

Cover -- Contents -- Preface -- Foreword -- Contributors -- Connecting Age-Related Biological Decline to Frailty and Late-Life Vulnerability -- Abstract -- Introduction -- Frailty Conceptualization -- Frailty Measurement -- The Biology That Underlies Frailty -- Disease States and Frailty -- Physiological System Dysregulation and Frailty -- Age-Related Cellular and Molecular Changes and Frailty -- Disclosure Statement -- References -- Cellular Senescence and the Biology of Aging, Disease, and Frailty -- Abstract -- Introduction -- Cellular Senescence, the Senescence-Associated Secretory Phenotype, and Aging -- Cellular Senescence and Age-Related Disease and Frailty -- Interventions Targeting Senescent Cells and the Senescence-Associated Secretory Phenotype -- Conclusions -- Acknowledgments -- Disclosure Statement -- References -- The Role of Genome Instability in Frailty: Mitochondria versus Nucleus -- Abstract -- Introduction -- Cellular and Mitochondrial Mechanisms of Nuclear Genome Instability -- Mitochondrial Quality Control and Nuclear Genome Stability -- Concluding Remarks -- Acknowledgments -- Disclosure Statement -- References -- Determinants of Frailty and Longevity: Are They the Same Ones? -- Abstract -- Introduction -- Longevity and Functional Reserve -- Disease, Functional Reserve, and Frailty -- Longevity and Frailty: Biological Background -- Disclosure Statement -- References -- Psychological Frailty in the Aging Patient -- Abstract -- Introduction -- Frailty -- Psychological Frailty -- Disclosure Statement -- References -- Frailty Clinical Phenotype: A Physical and Cognitive Point of View -- Abstract -- Introduction -- Physical Frailty: From Concept to Clinical Practice -- Cognitive Frailty: From Concept to Operational Definition -- Redefining Frailty: Emerging Definitions -- Conclusion -- Acknowledgments -- Disclosure Statement.

Cellular Ageing and Replicative Senescence

Cellular Ageing and Replicative Senescence
Author: Suresh I.S. Rattan,Leonard Hayflick
Publsiher: Springer
Total Pages: 364
Release: 2016-05-09
ISBN 10: 3319262394
ISBN 13: 9783319262390
Language: EN, FR, DE, ES & NL

Cellular Ageing and Replicative Senescence Book Review:

This book covers the origins and subsequent history of research results in which attempts have been made to clarify issues related to cellular ageing, senescence, and age-related pathologies including cancer. Cellular Ageing and Replicative Senescence revisits more than fifty-five years of research based on the discovery that cultured normal cells are mortal and the interpretation that this phenomenon is associated with the origins of ageing. The mortality of normal cells and the immortality of cancer cells were also reported to have in vivo counterparts. Thus began the field of cytogerontology. Cellular Ageing and Replicative Senescence is organized into five sections: history and origins; serial passaging and progressive ageing; cell cycle arrest and senescence; system modulation; and recapitulation and future expectations. These issues are discussed by leading thinkers and researchers in biogerontology and cytogerontology. This collection of articles provides state-of-the-art information, and will encourage students, teachers, health care professionals and others interested in the biology of ageing to explore the fascinating and challenging question of why and how our cells age, and what can and cannot be done about it.

Frailty and Cardiovascular Diseases

Frailty and Cardiovascular Diseases
Author: Nicola Veronese
Publsiher: Springer Nature
Total Pages: 154
Release: 2020-01-01
ISBN 10: 3030333302
ISBN 13: 9783030333300
Language: EN, FR, DE, ES & NL

Frailty and Cardiovascular Diseases Book Review:

This book aims to clarify the potential association between frailty and cardiovascular disease in older people. Covering the biological as well as the clinical point of view, it allows researchers and clinicians to discover the significance of this topic. The contributions cover the most important aspects in the potential relationship between frailty and cardiovascular disease. In particular, authoritative authors in this field have clarified the definition and the epidemiology of frailty and cardiovascular disease in older people. A large part of the volume is dedicated to the biological mechanisms of frailty and cardiovascular disease, trying to find those in common between these two conditions. Since this book is dedicated to both researchers and clinicians, we have proposed some chapters to the importance of comprehensive geriatric assessment in the evaluation and treatment of cardiovascular diseases and frailty. In this regard, the importance of geriatric evaluation in cardiac surgery for older people is well covered. Finally, the importance of cardiac rehabilitation and physical exercise is summarized, being, actually, the most important treatments for both frailty and cardiovascular disease. Written by many well-known and widely published experts in their respective fields, this book will appeal to a wide readership such as researchers in the field and clinicians, especially suited in geriatric medicine and cardiology who, every day, face frail older patients.

Endothelial Dysfunction

Endothelial Dysfunction
Author: Helena Lenasi
Publsiher: BoD – Books on Demand
Total Pages: 430
Release: 2018-10-24
ISBN 10: 1789842530
ISBN 13: 9781789842531
Language: EN, FR, DE, ES & NL

Endothelial Dysfunction Book Review:

The endothelium enables communication between blood and tissues and is actively involved in cardiovascular homeostasis. Endothelial dysfunction has been recognized as an early step in the development of cardiovascular diseases: respectively, endothelium represents a potential therapeutic niche with multiple targets. The purpose of the book is to point out some recent findings of endothelial physiology and pathophysiology emphasizing various aspects of endothelial dysfunction connected to the body's internal and external environment. While basic features of the endothelium are presented in an introductory chapter, the authors of the following 17 chapters have provided extensive insight into some selected topics of endothelial (dys)function. The book would hopefully be useful for anyone interested in recapitulating endothelial (patho)physiology and expanding knowledge of molecular mechanisms involved in endothelial dysfunction, relevant also for further clinical investigations.

Telomere

Telomere
Author: Marcelo Larramendy
Publsiher: BoD – Books on Demand
Total Pages: 226
Release: 2016-11-23
ISBN 10: 9535127527
ISBN 13: 9789535127529
Language: EN, FR, DE, ES & NL

Telomere Book Review:

This book, Telomere - A Complex End of a Chromosome, is organized into nine chapters containing the latest aspects of the current knowledge about the structure of telomeres and the crucial role that telomerase plays not only in maintaining chromosomal stability but also in relation to cell immortality, cell instability, and cancer biology. We now appreciate that these unusual complexes of DNA and proteins we all know as "telomeres" are dynamic and key structures that depend on telomerase and other cellular factors for continuance. Regulation of telomere activity is a dynamic area of current research, and new insights into telomeres and their role in aging and cancer, among other biological functions and pathologies, appear regularly in the scientific world. However, one fact is more than understandable in this difficult biological conundrum: the end of the telomere story is far from being totally unraveled.

Aging

Aging
Author: L. Robert,T. Fulop
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 224
Release: 2014-05-16
ISBN 10: 3318026530
ISBN 13: 9783318026535
Language: EN, FR, DE, ES & NL

Aging Book Review:

Aging inspired a large number of theories trying to rationalize the aging process common to all living beings. In this publication the most important environmental and intrinsic mechanisms involved in the aging process and in its pathological consequences are reviewed. Furthermore theoretical and experimental evidence of the most important theoretical elements based on Darwinian evolution, cellular aging, role of cell membranes, free radicals and oxidative processes, receptor-mediated reactions, the extracellular matrix and immune functions as well as the most important environmental and intrinsic mechanisms involved in the aging process and in its pathological consequences are discussed. These presentations of theories and related experimental facts give a global overview of up to date concepts of the biology of the aging process and are of essential reading not only for specialists in this field but also for practitioners of scientific, medical, social and experimental sciences.

Metabolic and Bioenergetic Drivers of Neurodegenerative Disease Treating Neurodegenerative Diseases as Metabolic Diseases

Metabolic and Bioenergetic Drivers of Neurodegenerative Disease  Treating Neurodegenerative Diseases as Metabolic Diseases
Author: Anonim
Publsiher: Academic Press
Total Pages: 322
Release: 2020-08-25
ISBN 10: 012823122X
ISBN 13: 9780128231227
Language: EN, FR, DE, ES & NL

Metabolic and Bioenergetic Drivers of Neurodegenerative Disease Treating Neurodegenerative Diseases as Metabolic Diseases Book Review:

Metabolic Drivers and Bioenergetic Components of Neurodegenerative Disease reviews how the different aspects of metabolic dysfunction and consequent pathology associated with neurodegenerative diseases, including Alzheimer’s and Parkinson’s, can be targeted by novel treatment approaches. Topics covered include Cellular Senescence in Aging and Age-Related Disorders: Implications for Neurodegenerative Diseases; Repurposing GLP1 agonists for Neurodegenerative Diseases; Ketotherapeutics for Neurodegenerative Diseases; Enhancing Mitophagy as a Therapeutic Approach for Neurodegenerative Diseases; Harnessing Neurogenesis in the Adult Brain – A Role in Type 2 Diabetes Mellitus and Alzheimer’s disease; and much more. Summarizes the impact of the metabolic hypothesis on underlying mechanisms of neurodegenerative diseases Presents novel, potential treatment strategies based on the metabolic hypothesis for neurodegenerative diseases.

Hepatocellular Carcinoma

Hepatocellular Carcinoma
Author: Costin Teodor Streba,Cristin Constantin Vere,Ion Rogoveanu
Publsiher: BoD – Books on Demand
Total Pages: 200
Release: 2018-11-28
ISBN 10: 1789842735
ISBN 13: 9781789842739
Language: EN, FR, DE, ES & NL

Hepatocellular Carcinoma Book Review:

Hepatocellular carcinoma (HCC) currently ranks as the third most common cause of death. As the primary malignancy of the liver is directly related to an underlying liver condition, its incidence and profile are expected to change soon. While effective prevention programs and antiviral therapies for hepatitis B and C will lower the incidence of HCC, emerging socioeconomic issues will deliver new at-risk populations. Moreover, diagnostic techniques and protocols have undergone significant advancements. Reliance on contrast enhanced ultrasound has been re-evaluated, imaging methods being considered as sufficient diagnostic tools. Molecular characterization remains desirable, since chemotherapeutic agents still have limited applicability. In light of recent diagnostic advancements and novel therapeutic solutions, it is our belief that a comprehensive update on recent paradigm shifts and interesting upcoming developments is highly needed.

Telomeres and Telomerase in Aging Disease and Cancer

Telomeres and Telomerase in Aging  Disease  and Cancer
Author: K. Lenhard Rudolph
Publsiher: Springer Science & Business Media
Total Pages: 330
Release: 2007-11-07
ISBN 10: 354073709X
ISBN 13: 9783540737094
Language: EN, FR, DE, ES & NL

Telomeres and Telomerase in Aging Disease and Cancer Book Review:

Telomere shortening represents one of the basic aspects of ageing and telomere dysfunction could contribute to the accumulation of DNA damage during ageing. This book summarizes evidence and data indicating that telomere dysfunction influences human ageing, diseases and cancer. The book describes our current knowledge on checkpoints that limit cellular lifespan and survival in response to telomere dysfunction. There is special focus on adult stem cells.

Adult Stem Cells in Aging Diseases and Cancer

Adult Stem Cells in Aging  Diseases and Cancer
Author: K.L. Rudolph
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 88
Release: 2014-12-22
ISBN 10: 3318027324
ISBN 13: 9783318027327
Language: EN, FR, DE, ES & NL

Adult Stem Cells in Aging Diseases and Cancer Book Review:

The functionality of adult tissue stem cells from various organ systems declines during aging. This publication summarizes novel molecular mechanisms responsible for the development of aging-associated deficiencies as discussed by leading experts during the 5th Else Kröner-Fresenius Symposium. It is the first book that explicitly focuses on molecular mechanisms of stem cell aging and its consequences for disease and cancer development including both cell-intrinsic mechanisms as well as aging-induced alterations in the stem cell niche and the systemic environment. Cutting-edge information on stem cells, aging, cancer, and disease make this publication of special interest to basic researchers in the respective fields. Further, it is also intended for medical doctors in the fields of geriatrics, internal medicine, and cancer as it provides a novel understanding of the evolution of tissue dysfunction, diseases and cancer as a consequence of aging.

Cellular Senescence and Inflammation in Aging and Age related Disease

Cellular Senescence and Inflammation in Aging and Age related Disease
Author: Tobias Wijshake
Publsiher: Unknown
Total Pages: 135
Release: 2015
ISBN 10: 9789036777568
ISBN 13: 9036777569
Language: EN, FR, DE, ES & NL

Cellular Senescence and Inflammation in Aging and Age related Disease Book Review:

Handbook on Immunosenescence

Handbook on Immunosenescence
Author: Tamas Fulop,Claudio Franceschi,Katsuiki Hirokawa,Graham Pawelec
Publsiher: Springer Science & Business Media
Total Pages: 1693
Release: 2009-02-27
ISBN 10: 1402090633
ISBN 13: 9781402090639
Language: EN, FR, DE, ES & NL

Handbook on Immunosenescence Book Review:

This authoritative handbook covers all aspects of immunosenescence, with contributions from experts in the research and clinical areas. It examines methods and models for studying immunosenescence; genetics; mechanisms including receptors and signal transduction; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; and much more.