Cellular Endocrinology In Health And Disease Second Edition

Cellular Endocrinology in Health and Disease, Second Edition, describes the underlying basis of endocrine function, providing an important tool to understand the fundamentals of endocrine diseases. Delivering a comprehensive review of the basic science of endocrinology, from cell biology to human disease, this work explores and dissects the function of a number of cellular systems. The new edition provides an understanding of how endocrine glands function by integrating information resulting in biological effects on both local and systemic levels, also providing new information on the molecular physiopathogenesis of endocrine neoplasic cells. The new edition expands the most used chapters from the first edition and proposes a series of substitutions and additions to the table of contents. New chapters cover signaling, brown adipose tissue, hypothalamic cell models, cellular basis of insulin resistance, genetics and epigenetics of neuroendocrine tumors, and a series of chapters on endocrine-related cancer. Providing content that crosses disciplines, Cellular Endocrinology in Health and Disease, Second Edition, details how cellular endocrine function contributes to system physiology and mediates endocrine disorders. A methods section proves novel and useful approaches across research focus that will be attractive to medical students, residents, and specialists in the field of endocrinology, as well as to those interested in cellular regulation. Editors Alfredo Ulloa-Aguirre and Ya-Xiong Tao, experts in molecular and cellular aspects of endocrinology, deliver contributions carefully selected for relevance, impact, and clarity of expression from leading field experts Explores endocrine cells biology in normal and pathologic conditions Covers new aspects of endocrine cell function in distinct tissues Provides a view into the biological effect in local and systemic levels 15 new chapters covering the recent developments in the field

Growing sentiments against using micronutrient supplements for improving health and preventing disease have created uncertainty in the minds of many health professionals. Following its predecessor, this new edition supports the use of multiple micronutrients combined with proper diet to prove successful in the prevention and management of chronic diseases. It provides basic information on micronutrients, oxidative stress, inflammation, and the immune system. The book goes further to explore use of multiple micronutrients in prevention and treatment of diseases including arthritis, cancer, diabetes, heart diseases, traumatic brain injury, PTSD, prion diseases, and autism spectrum disorder. Key Features Proposes sevidence-based micronutrient supplementation strategies for healthy aging and disease management and prevention. Contains three new chapters on Huntington’s Disease, prion diseases, and autism spectrum disorder. All chapters include new studies on etiology, incidence, and mechanisms of several diseases. Discusses role of microRNAs in the initiation and progression for each disease.

This updated edition is a comprehensive treatise that spans the complete range of basic biochemistry of bone and cartilage components to the clinical evaluation of disease markers in bone and joint disorders. With contributions from over 75 international experts, Dynamics of Bone and Cartilage Metabolism, Second Edition, is indispensable reading for those involved in skeletal research as well as for rheumatologists, endocrinologists, clinical biochemists, and other clinical disciplines participating in the management of patients with bone and cartilage diseases. Part I provides an up-to-date account of current knowledge of the structure, biosynthesis and molecular biology of the major tissue components Part II covers the organizational structure and cellular metabolism of bone and cartilage Part III deals with the utility of components specific to bone and cartilage as biomarkers of health and disease

Encyclopedia of Endocrine Diseases, Second Edition, comprehensively reviews the extensive spectrum of diseases and disorders that can occur within the endocrine system. It serves as a useful and comprehensive source of information spanning the many and varied aspects of the endocrine end metabolic system. Students will find a concise description of the physiology and pathophysiology of endocrine and metabolic functions, as well as their diseases. Each article provides a comprehensive overview of the selected topic to inform a broad spectrum of readers, from advanced undergraduate students, to research professionals. Chapters explore the latest advances and hot topics that have emerged in recent years, such as the molecular basis of endocrine and metabolic diseases (mutations, epigenetics, signaling), the pathogenesis and therapy of common endocrine diseases (e.g. diabetes and endocrine malignancies), new technologies in endocrine research, new methods of treatment, and endocrine toxicology/disruptors. Covers all aspects of endocrinology and metabolism Incorporates perspectives from experts working within the domains of biomedicine (e.g. physiology, pharmacology and toxicology, immunology, genetics) and clinical sciences to provide readers with reputable, multi-disciplinary content from domain experts Provides a ‘one-stop’ resource for access to information as written by world-leading scholars in the field, with easy cross-referencing of related articles to promote understanding and further research

The Textbook of Nephro-Endocrinology is the definitive translational reference in the field of nephro-endocrinology, investigating both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems. It offers researchers and clinicians expert, gold-standard analyses of nephro-endocrine research and translation into the treatment of diseases such as anemia, chronic kidney disease (CKD), rickets, osteoporosis, and, hypoparathyroidism. Investigates both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems Presents a uniquely comprehensive and cross-disciplinary look at all aspects of nephro-endocrine disorders in one reference work Clear translational presentations by the top endocrinologists and nephrologists in each specific hormone or functional/systems field

Authoritative researchers and clinicians review our latest understanding of andrology in both basic science and clinical medicine. Topics range from explaining the biology of androgens-from several different perspectives-to illuminating their role in the development and modulation of physiologic systems. Authors demonstrate in a number of cases that testosterone can be a useful adjunct to the treatment of a variety of disease states. Other chapters consider important topics such as androgens use in athletes, the potential of androgens to improve physical function and quality of life in older men, and androgens as potential male contraceptives.

The field of adipose tissue biology has been expanding at a very rapid pace in the last few years. Numerous advances have been made since publication of the first edition of this book, in terms of basic adipocyte biology, understanding of the determinants of obesity, distribution of body fat and weight loss, as well as the mechanisms linking excess adiposity to various co-morbidities. Adipose Tissue and Adipokines in Health and Disease, Second Edition contains updated chapters from the previous volume but as the field has evolved, some areas covered in the first edition have been refocused to address the new knowledge. The volume is divided in four sections: the first two deal with basic adipose tissue and adipokine biology, while the last two address the problem of obesity and alterations in adipose tissue function from an epidemiological and clinical standpoint. The chapters are written by experts in their fields and include the most up to date scientific information. Adipose Tissue and Adipokines in Health and Disease, Second Edition is a useful resource for physicians interested in adipose tissue biology and basic scientists who want to know more about applied aspects of the field. The book targets endocrinologists, residents and fellows, internists, nutritionists and general practitioners who are exposed to an ever-expanding obese population.

Polyphenols in Prevention and Treatment of Human Disease, Second Edition authoritatively covers evidence of the powerful health benefits of polyphenols, touching on cardiovascular disease, cancer, obesity, diabetes and osteoporosis. This collection represents the contributions of an international group of experts in polyphenol research who share their expertise in endocrinology, public health, cardiology, pharmacology, agriculture and veterinary science. Researchers from diverse backgrounds will gain insight into how clinical observations and practices can feed back into the research cycle, thus allowing them to develop more targeted insights into the mechanisms of disease. This reference fills a void in research where nutritionists and alternative therapies may be applicable. Describes polyphenol modulation of blood flow and oxygenation as a potential mechanism of protection against vascular atherosclerosis Describes how polyphenols and antioxidants frequently change immune defenses and actions Focuses on the most important areas of research and provides insights into their relationships and translational opportunities

This book identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluations of treatments. The book is aimed at all students of bone biology and genetics, and with this in mind, it includes general introductory chapters on genetics and bone biology and more specific disease-orientated chapters, which comprehensively summarize the clinical, genetic, molecular genetic, animal model, functional and molecular pathology, diagnostic, counselling and treatment aspects of each disorder. Saves academic, medical, and pharma researchers time in quickly accessing the very latest details on a broad range of genetic bone issues, as opposed to searching through thousands of journal articles. Provides a common language for bone biologists and geneticists to discuss the development of bone cells and genetics and their interactions in the development of disease Researchers in all areas bone biology and genetics will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic and proteomic assays For those clinical researchers who are also MDs, correct diagnosis (and therefore correct treatment) of bone diseases depends on a strong understanding of the molecular basis for the disease.

This work explores and analyses the ways in which our ancient genes contend with, and influence, modern human life. It offers coverage of the points of contact between evolutionary biology and medical science.

Hormones, Fourth Edition provides a report on the field of human hormones viewed in light of our current understanding of cellular and subcellular architecture, along with the molecular details of their modes of action. Comprehensive information about hormone action on canonical and non-canonical signaling pathways at cellular and subcellular level and effects on architecture and function of organ systems are discussed. All chapters in this new edition have been completely updated to cover advances in endocrinology research, which has expanded significantly in the last few years. Vast coverage of hormones not previously covered and newly discovered aspects of hormone action are also included. This new fourth edition is intended to be used by advanced undergraduates and graduate students in the biological sciences. It will also provide useful background information for health professionals, clinicians and researchers in the field of endocrinology, metabolism and biochemistry. Includes updates on all chapters Covers sleep hormones, growth factors, intestinal hormones, calcium-sensing receptor of parathyroid, and others Provides essential basics for advanced undergraduates, graduate students and researchers in the biological sciences, as well as clinical aspects and applications for clinicians Presented in separate hormone systems, covering the subcellular mode of action of selected hormones and a detailed understanding of their human anatomy and physiology

In this practical book, the authors of each chapter have synthesized the currently available evidence regarding specific issues in diabetes care. The chapters have been written by an interdisciplinary team of scientists and medical professionals. Such an approach emphasizes the need for collaboration in the care of any individual with diabetes and in the effort to find new therapies for the disease. This reference provides practical guidance in a single resource.

This book covers the most important clinical and bench science aspects of metabolic syndrome. It will be of value to all of those seeking a comprehensive update on the metabolic syndrome. Furthermore, it will provide a broad basis for advancing research in the multiple intersecting disciplines encompassed by the metabolic syndrome.

In this second edition of his popular and widely acclaimed book, Lewis Braverman and a panel of international authorities have thoroughly updated and revised the first edition with fresh perspectives, many new authors, and the latest scientific and clinical developments in thyroid disease. New to this edition are the clinical relevance of the sodium/iodide symporter (NIS), broad coverage of autoimmune thyroid disease, and expanded coverage of thyroid cancer, including recombinant human TSH. Other chapters discuss such important topics as thyroid dysfunction during pregnancy and postpartum, thyroid disease in children and the elderly, the evaluation and management of nodular goiter, the worldwide problem of iodine deficiency and its eradication, and environmental goitrogens. Authoritative and up-to-date, Diseases of the Thyroid, Second Edition, provides internists, family physicians, obstetricians and gynecologists, and endocrinologists alike with a highly readable guide not only to understanding thyroid disorders, but also to their optimal clinical management.

Animal Models for the Study of Human Disease, Second Edition, provides needed information on model sharing, animal alternatives, animal ethics and access to databanks of models, bringing together common descriptions of models for busy researchers across biomedical and biological sciences. Offering easily searchable advantages and disadvantages for each animal model and organized by disease topics, this resource aids researchers in finding the best animal model for research in human disease. Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives, and animal ethics Covers a broad range of animal models used in research for human disease Contributed by leading experts across the globe Expanded coverage of diabetes and neurological diseases

The field of androgen excess disorders has advanced substantially since the original publication of this book. The Androgen Excess Society (AES) was founded to bring together investigators in the field. A better understanding of the screening, progression, and molecular genetics of nonclassic adrenal hyperplasia (NCAH) has improved the clinical care and diagnostic accuracy of these patients. New criteria for the diagnosis of the polycystic ovary syndrome (PCOS) were proposed in Rotterdam, criteria that have resulted in controversy and, hopefully, initiation of new studies. The association of insulin resistance with PCOS has been strengthened, and the role of metformin in tre- ing the infertility of the PCOS has been validated. Risks for diabetes and, more cont- versially, cardiovascular disease in women with PCOS have received substantial investigation. Our understanding of the epidemiology and economic impact of these disorders has expanded, emphasizing their critical importance. These are but a few highlights of how the terrain has changed in a relatively brief period of time. In keeping with these advances, the title of this book has been revised to reflect the growing importance of PCOS as the most prevalent androgen excess disorder in women, and arguably, as the one that might have the most serious adverse consequences for general health. There are fewer chapters to provide a more focused elucidation of the area. Several chapters were penned by new (and young) authors who are conducting cutting-edge research in the field.

"Aldwin and Gilmer have supplied an interesting textual model for examining health, illness, and aging. Their homogenized approach to aging research is refreshing and insightful."--Anthropology and Aging Quarterly "Clearly written at a level for college students, this is an excellent resource on aging...Highly recommended.--Choice: Current Reviews for Academic Libraries Spanning the biological and psychosocial aspects of aging, this upper-level undergraduate and graduate text integrates current findings in biology, psychology, and the social sciences to provide comprehensive, multidisciplinary coverage of the aging process. This new edition incorporates the tremendous amount of research that has come to light since the first edition was published. From a physical perspective, the text examines age-related changes and disease-related processes, the demography of the aging population, aging theories, and how to promote optimal aging. Coverage of the psychosocial aspects of aging encompasses mental health, stress and coping, spirituality, and caregiving in later years. The authors address demographic, theoretical, and methodological issues on aging, including a worldwide overview of aging demographics. The book reviews biological and psychosocial theories and offers much-needed information on longitudinal design and statistics as they relate to aging research. It discusses the aging of the major organ systems, the brain and sensory systems, and the endocrine and immune systems; basic anatomy and physiology; normal, impaired, and optimal aging; and functional health. Psychosocial factors that affect health are addressed, including the interplay between physical health and mental health, stress, coping, and social support. The text also covers current issues in social gerontology, including such promising new trends as gerontechnology and Green Houses, and provides information on health promotion programs. New to the Second Edition: Information involving retirement, volunteer opportunities, housing, and adaptation to health changes Coverage of economics and aging, including information on social security and other retirement income and the future of Medicare and Medicaid Significant new information about the regulatory systems Revised and updated chapters on death and dying and optimal aging Discussions on two models of optimal aging and valuable tips for its promotion URLs to relevant websites for additional information

Maintaining the original goal of the first edition to integrate the basic science of endocrinology with its physiological and clinical principles, this new edition succinctly summarizes in 450 pages the latest findings on hormone secretion and hormone action, as well as all the most recent insights into the physiology and pathophysiology of hormonal disorders. Coverage extends across the entire spectrum of endocrinology-from mammalian cells, plants, and insects to animal models and human diseases-with much increased coverage of diabetes and metabolism. Highlights include cutting-edge discussions of appetite disorders, obesity, reproductive failure, control of thyroid function, hormone action in man and the lower species, and the mechanisms subserving hormone secretion.

Since the publication of the first edition, the U.S. Surgeon General released the first-ever report on bone health and osteoporosis in October 2004. This report focuses even more attention on the devastating impact osteoporosis has on millions of lives. According to the National Osteoporosis Foundation, 2 million American men have osteoporosis, and another 12 million are at risk for this disease. Yet despite the large number of men affected, the lack of awareness by doctors and their patients puts men at a higher risk that the condition may go undiagnosed and untreated. It is estimated that one-fifth to one-third of all hip fractures occur in men. This second edition brings on board John Bilezikian and Dirk Vanderschueren as editors with Eric Orwoll. The table of contents is more than doubling with 58 planned chapters. The format is larger – 8.5 x 11. This edition of Osteoporosis in Men brings together even more eminent investigators and clinicians to interpret developments in this growing field, and describe state-of-the-art research as well as practical approaches to diagnosis, prevention and therapy. Brings together more eminent investigators and clinicians to interpret developments in this growing field. Describes state-of-the-art research as well as practical approaches to diagnosis, prevention and therapy. There is no book on the market that covers osteoporosis in men as comprehensively as this book.

The go-to guide for managing endocrine problems in children – completely updated for today’s practice Part of the Pediatric Practice series, Pediatric Practice: Endocrinology is an outstanding clinical analysis and decision-making tool for those treating endocrine problems in children. Featuring an innovative problem-oriented approach, this well-illustrated, full-color guide skillfully integrates pathophysiology with clinical management. Numerous figures illustrate the principles of normal and abnormal physiology and treatment rationale and effects. Since an understanding of the clinical manifestations and treatments of endocrine disorders begins with knowledge of concepts of hormone action and principles of feedback control, the first chapter, "General Concepts and Physiology," links genetics, cell biology, and physiology with pathophysiology to provide a clear and approachable overview of endocrine systems. Subsequent chapters discuss disorders of growth, puberty, thyroid and adrenal glands, sex development, calcium and bone metabolism, water homeostasis, and carbohydrate metabolism and its comorbidities. In this second edition, contributing authors have updated all chapters. Important additions include sections on genetics for the endocrinologist in the general concepts chapter, an overview of the physiology and treatment of metabolic syndrome and dyslipidemia in the obesity chapter, and the addition of a new chapter on enteric hormones. Features of the Pediatric Practice Series The Pediatric Practice series simplifies the care of pediatric patients by delivering: Tips that tell you what you must know--and what you must do--at every stage of care Diagnostic and treatment algorithms Signs/Symptoms and Differential Diagnosis boxes When to Refer boxes, which examine all the relevant clinical considerations Diagnostic Tests--with a realistic emphasis on the right tests to order Medical Treatment coverage that includes drugs, dosages, and administration in an easy-to-read tabular format Convenient icons and a consistent chapter design Numerous clinical color photos and didactic diagrams