Breaking Tolerance to Unresponsiveness to Immunotherapy by Natural Killer Cells

Breaking Tolerance to Unresponsiveness to Immunotherapy by Natural Killer Cells
Author: Sandro Matosevic
Publsiher: Academic Press
Total Pages: 200
Release: 2021-01-29
ISBN 10: 9780128206270
ISBN 13: 0128206276
Language: EN, FR, DE, ES & NL

Breaking Tolerance to Unresponsiveness to Immunotherapy by Natural Killer Cells Book Review:

Breaking Tolerance to Unresponsiveness to Immunotherapy by Natural Killer Cells presents chapters by leaders in translational natural killer cell research and bridges the gap between clinical need and basic science by presenting state-of-the-art knowledge on innate immunity and the challenges associated with translating it to practical adoptive immunotherapies. New approaches, such as the genetic engineering of NK cells and their combination with checkpoint blockade therapies are discussed among other potential interventions to improve natural killer cell functionality against targets. In addition, challenges, such as the difficulty in genetically modifying NK cells or a poor understanding of their effect on checkpoint inhibition are included. The book is a key reference and go-to resource for researchers and clinicians who want to understand the current limitations associated with bringing natural killer cell-based immunotherapies to the clinic. Discusses translational aspects from leaders in the field to facilitate readers' understanding of clinical challenges Addresses important events that occur in patient tumor microenvironments as they pertain to NK cells and how they are, or can be, tackled to overcome immunosuppression of NK cells Focuses on immunometabolism by discussing the metabolic reprogramming that NK cells undergo in solid tumors, including hypoxia, adenosine and other metabolites

Immunotherapeutic Strategies for the Treatment of Glioma

Immunotherapeutic Strategies for the Treatment of Glioma
Author: Christopher Jackson,Michael Lim
Publsiher: Academic Press
Total Pages: 190
Release: 2021-09-10
ISBN 10: 0128197560
ISBN 13: 9780128197561
Language: EN, FR, DE, ES & NL

Immunotherapeutic Strategies for the Treatment of Glioma Book Review:

Immunotherapeutic Strategies for the Treatment of Glioma provides a review of the current state of immunotherapy for primary brain tumors. The topic is of interest to patients, clinicians, and researchers alike, particularly given the recent failure of large clinical trials. This book serves as an overview of the most promising approaches in the field and provides a foundation for considering novel and combination therapies moving forward. The book discusses several types of immunotherapies for glioma, such as peptide, dendritic cell and heat shock protein vaccines; immune checkpoint blockade; myeloid cells as target; oncolytic viruses; and CAR T cell therapy. Additionally, it discusses the mechanisms of immune suppression in patients and immunogenomics. This volume is a valuable source for cancer researchers, oncologists and several members of biomedical field who are interested in novel strategies to fight glioblastoma. Summarizes the work in immunotherapy for glioma to-date, including the available evidence from preclinical studies and clinical trials Reviews the challenges and successes of the most promising strategies for brain tumor immunotherapy Provides a foundation for considering novel and combination therapies moving forward

Immunotherapy in Resistant Cancer From the Lab Bench Work to Its Clinical Perspectives

Immunotherapy in Resistant Cancer  From the Lab Bench Work to Its Clinical Perspectives
Author: Jorge Morales Montor,Mariana Segovia
Publsiher: Academic Press
Total Pages: 288
Release: 2020-10-01
ISBN 10: 0128220295
ISBN 13: 9780128220290
Language: EN, FR, DE, ES & NL

Immunotherapy in Resistant Cancer From the Lab Bench Work to Its Clinical Perspectives Book Review:

Immunotherapy in Resistant Cancer: From the Lab Bench Work to Its Clinical Perspectives provides high level knowledge on detailed mechanisms of actions and biological interactions of different immune drugs, with an aim of offering researchers and clinicians cutting-edge therapies to overcome drug resistance. The book explains the latest immunotherapies for different types of cancer, helping users carry out research projects or create alternatives for drug development in the pharmaceutical industry. Topics discussed include the relationship between immunotherapy and macrophages, immune checkpoints in different types of cancer, immune cocktails in solid tumors, and immune-phenotyping. Additionally, the book presents basic and clinical data on immunoresistance and glycosylation. This book is a valuable source for cancer researchers, medical doctors, clinicians and members of the biomedical field who must understand certain mechanisms to fight cancer that is resistant to immunotherapy. Provides basic and clinical evidence based on molecular interactions and clinical studies to address the risks and benefits of cancer immunotherapy Presents the results of new immunotherapy trials, discussing the state-of-the-art in different types of cancer Discusses targeted therapies approved by the FDA, along with therapies with clinical potential used in basic studies

Improving the Therapeutic Ratio in Head and Neck Cancer

Improving the Therapeutic Ratio in Head and Neck Cancer
Author: Anonim
Publsiher: Academic Press
Total Pages: 376
Release: 2019-10-04
ISBN 10: 0128178698
ISBN 13: 9780128178690
Language: EN, FR, DE, ES & NL

Improving the Therapeutic Ratio in Head and Neck Cancer Book Review:

Improving the Therapeutic Ratio in Head and Neck Cancer provides a complete review of current approaches to modulating therapeutic sensitivity in head and neck cancer. It presents a broad background of current approaches and by highlighting the potential for clinical translational, introduces a roadmap for how to move promising preclinical findings into the clinic. The book discusses topics such as immunotherapy and molecularly targeted therapies in head and neck cancer, PI3k/mTOR pathway, autophagy inhibition to sensitize HNC to radiation and chemotherapy, TAM and Eph/Ephrin family proteins and metabolic reprogramming to modulate therapeutic sensitivity. Additionally, it details approaches to improve the response to immunotherapy, and Chk1/2 inhibition in radiation and cetuximab resistance. This book is a valuable source to head and neck cancer researchers and advanced students, and to those studying specific approaches in other model systems and disease sites. Provides key scientific background for clinicians when developing novel clinical trials and important examples for basic scientists of the types of work required to move a concept from the lab to the clinic Presents consistent pathway diagrams in each chapter, thus making it easier to understand complicated pathways Includes chapter summaries of the critical next steps needed to move studies from their current state into practice changing clinical data

Successes and Challenges of NK Immunotherapy

Successes and Challenges of NK Immunotherapy
Author: Benjamin Bonavida,Anahid Jewett
Publsiher: Academic Press
Total Pages: 538
Release: 2021-06-23
ISBN 10: 0128243961
ISBN 13: 9780128243961
Language: EN, FR, DE, ES & NL

Successes and Challenges of NK Immunotherapy Book Review:

Successes and Challenges of NK Immunotherapy: Increasing Anti-tumor Efficacy describes the unique therapeutic applications of NK cells to fight cancers and eliminate the bulk and subset of cancer stem cells responsible for metastasis, relapse and recurrences. The book provides information on the development, engineering, mechanisms of action, response to various preclinical models, and applications in various clinical trials. Sections cover the development of highly engineered cytotoxic NK cells, their mechanisms of action, preclinical and clinical applications, the development and application of CAR-NK cells, and new NK-drug conjugates, also emphasizing that activated NK cells can target and kill highly resistant cancer stem cells. Written by the leading experts on NK immunotherapy worldwide, this is a valuable resource for researchers, clinicians and members of the biomedical field who are interested in understanding novel and efficient therapies to fight cancers. Discusses the unique developmental applications of NK immunotherapy against cancers, which differs greatly from other types of immunotherapies Provides up-to-date and highly relevant information through chapters written by the leading researchers in the field Presents a significant number of schematic diagrams for easy understanding and reproducibility

Cancer Immunotherapy at the Crossroads

Cancer Immunotherapy at the Crossroads
Author: James H. Finke,Ronald M. Bukowski
Publsiher: Springer Science & Business Media
Total Pages: 386
Release: 2003-11-24
ISBN 10: 1592597432
ISBN 13: 9781592597437
Language: EN, FR, DE, ES & NL

Cancer Immunotherapy at the Crossroads Book Review:

Leading investigators and clinicians detail the different mechanisms used by tumors to escape and impair the immune system and then spell out possible clinical strategies to prevent or reverse tumor-induced immune dysfunction. The authors review the mechanisms of immune dysfunction and evasion mechanisms in histologically diverse human tumors, focusing on tumor-induced molecular defects in T cells and antigen-presenting cells (dendritic cells and tumors), that may serve as biomarkers for patient prognosis. They discuss the means by which these immune functions may be protected or restored in order to more effectively support the process of tumor rejection in situ. Cutting-edge techniques are outlined with the capacity to monitor the strength and quality of patients' immune responses using immunocytometry, MHC-peptide tetramers combined with apoptosis assay, ELISPOT assay, and detection of MHC-TAA peptide complexes on tumor cells.

Renal Cell Carcinoma

Renal Cell Carcinoma
Author: Eric A. Klein
Publsiher: CRC Press
Total Pages: 370
Release: 1993-04-23
ISBN 10: 9780824790332
ISBN 13: 0824790332
Language: EN, FR, DE, ES & NL

Renal Cell Carcinoma Book Review:

This reference brings together all aspects of renal cell carcinoma, and provides a basis for understanding the disease's origin, progression and responses to immunotherapy.;Examining the current status of cytokine, cell-based and chemotherapeutic methods of treatment, this book: discusses the clinical presentation of advanced renal carcinoma and its therapeutic challenges; reviews prognostic factors and the management of renal cell carcinoma occurring with von Hippel-Landau syndrome; summarizes efforts to identify the tumour suppressor gene deleted from chromosome 3 in most renal cell carcinomas; explicates the role of oncogenes in the progression of renal cell cancer and the molecular correlates of responses to interferon-alpha treatment; details the latest laboratory efforts to establish gene therapy for tumour treatment by transfection of cytokine genes in murine model systems; focuses on biologic response modifier therapy in humans, including cell-mediated immune responses and adoptive immunotherapy; presents preclinical and clinical studies of interleukin-2 alone, in combination with othe cytokines, and with chemothrapeutic agents; and addresses studies on the tumour necrosis factor and low- and high-dose interferon-alpha.

Emerging Therapeutics for Immune Tolerance

Emerging Therapeutics for Immune Tolerance
Author: Hyewon Phee,Byron Au-Yeung,Thomas Malek,James Moon
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2021-11-30
ISBN 10: 2889717410
ISBN 13: 9782889717415
Language: EN, FR, DE, ES & NL

Emerging Therapeutics for Immune Tolerance Book Review:

Cancer Immunotherapy Principles and Practice Second Edition

Cancer Immunotherapy Principles and Practice  Second Edition
Author: Lisa H. Butterfield, PhD,Howard L. Kaufman, MD, FACS,Francesco M. Marincola, MD, FACS
Publsiher: Springer Publishing Company
Total Pages: 1000
Release: 2021-08-25
ISBN 10: 0826137431
ISBN 13: 9780826137432
Language: EN, FR, DE, ES & NL

Cancer Immunotherapy Principles and Practice Second Edition Book Review:

Thoroughly updated to reflect major advances in the field of immuno-oncology, this second edition of Cancer Immunotherapy Principles and Practice, from the Society for Immunotherapy of Cancer (SITC), remains the definitive resource for information on tumor immunology and cancer immunotherapy treatments. An essential reference for both novice and experienced cancer researchers, oncologists, and related practitioners alike, the book not only guides readers through the fundamental scientific principles of the field all the way to translational and practical clinical applications for treating and managing oncologic disease, but also provides a comprehensive understanding of the regulatory processes that support the safe and effective delivery of immunotherapy to patients with cancer. The expanded and updated second edition now spans 68 chapters, including 12 new chapters, covering major topics and innovations that have shaped the rapid development of immunotherapy and its ascension into the standard of care as first-line treatment for a growing number of disease settings. New to this edition are chapters with deeper insight into our understanding of cancer genomics and determinants of response, immunogenic cell death, cancer and stromal cell-intrinsic pathways of immune resistance, cancer immune exclusion, adoptive cell therapy, metabolomics, tumor mutation burden, immunotherapy in combination with radiation therapy, synthetic biology, and more. Complete with detailed illustrations, tables, and key points for targeted reference, Cancer Immunotherapy Principles and Practice, Second Edition is the most comprehensive and authoritative resource for scientists and clinicians looking to expand their knowledge base of this dynamic field. Key Features: Offers key insights and perspectives on cancer immunology and immunotherapy treatments from renowned experts in the field Covers the basic principles and science behind cancer immunotherapy and tumor immunology Includes treatment strategies for a vast array of available immunotherapy classes and agents, such as cytokine therapies, oncolytic viruses, cancer vaccines, CAR T therapies, and combination immunotherapies Provides essential information on FDA-approved immunotherapies, including clinical management and outcome data related to response rates, risks, and toxicities Discusses special considerations for immunotherapy in the context of specific disease settings, including skin cancers, genitourinary cancers, gastrointestinal cancers, hepatocellular carcinomas, gynecologic malignancies, breast cancers, lung cancers, head and neck cancers, brain tumors, sarcomas, pediatric cancers, and treatments combined with radiation therapy Clarifies the complex regulatory aspects behind the development and approval of immunotherapy drugs

Chemical Abstracts

Chemical Abstracts
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 2002
ISBN 10: 1928374650XXX
ISBN 13: UOM:39015057321377
Language: EN, FR, DE, ES & NL

Chemical Abstracts Book Review:

Trends in Allergic Conditions Among Children

Trends in Allergic Conditions Among Children
Author: Kristen D. Jackson,LaJeana D. Howie,Omolara Jean Akinbami
Publsiher: Unknown
Total Pages: 8
Release: 2013
ISBN 10: 1928374650XXX
ISBN 13: UCR:31210023846601
Language: EN, FR, DE, ES & NL

Trends in Allergic Conditions Among Children Book Review:

Cumulated Index Medicus

Cumulated Index Medicus
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 1999
ISBN 10: 1928374650XXX
ISBN 13: OSU:32436010790309
Language: EN, FR, DE, ES & NL

Cumulated Index Medicus Book Review:

Cell Reprogramming for Immunotherapy

Cell Reprogramming for Immunotherapy
Author: Samuel G. Katz,Peter M. Rabinovich
Publsiher: Humana
Total Pages: 343
Release: 2019-11-28
ISBN 10: 9781071602027
ISBN 13: 1071602020
Language: EN, FR, DE, ES & NL

Cell Reprogramming for Immunotherapy Book Review:

This volume details key protocols for developing strategies in immunotherapy. Chapters guide the readers through protocols related to various DNA, RNA and protein methods to reprogram the immune system, immune cells, analyzing the effect of the reprogrammed cells, and key methods to consider and analyze patients enrolled in clinical trials with novel immunotherapy regimens. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Cell Reprogramming for Immunotherapy: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Harnessing Oncolytic Virus mediated Antitumor Immunity

Harnessing Oncolytic Virus mediated Antitumor Immunity
Author: Philippe Fournier,Volker Schirrmacher
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2015-03-02
ISBN 10: 2889194507
ISBN 13: 9782889194506
Language: EN, FR, DE, ES & NL

Harnessing Oncolytic Virus mediated Antitumor Immunity Book Review:

Oncolytic viruses (OVs) have emerged as a promising anticancer treatment. OVs selectively infect, replicate in, and kill tumor cells. Oncolytic viral therapy occurs in two phases: an initial phase where the virus mediates direct oncolysis of tumor cells, and a second phase where an induced post-oncolytic immune response continues to mediate tumor destruction and retards progression of the disease. For a long time, the therapeutic efficacy was thought to depend mainly on the direct viral oncolysis based on their tumor selective replication and killing activities. But the post-oncolytic anti-tumor activity induced by the OV therapy is also a key factor for an efficient therapeutic activity. The topic adresses various strategies how to optimize OVs anti-tumor activity.

Transplantation Immunology

Transplantation Immunology
Author: Fritz H. Bach,Hugh Auchincloss
Publsiher: Wiley-Liss
Total Pages: 409
Release: 1995-08-18
ISBN 10: 1928374650XXX
ISBN 13: UOM:39015034864515
Language: EN, FR, DE, ES & NL

Transplantation Immunology Book Review:

Transplantation Immunology Edited by Fritz H. Bach, M.D., and Hugh Auchincloss, Jr., M.D. In recent years, transplantation immunology has evolved as a distinct field founded on the recognition that rejection of a transplanted organ or tissue is mediated by immune mechanisms in the host responding to antigens in the donor tissue. This book provides a comprehensive, up-to-date review of current knowledge regarding the specific immune mechanisms which can cause recipients to reject clinical transplants. The text is divided into four sections: Major and Minor Histocompatibility Antigens, Immunobiology of Graft Rejection, Clinical Transplantation, and Frontiers in Transplantation. The first two sections cover present-day understanding of the genetic controls of immunity as well as the two basic concerns of transplantation immunology, namely donor tissue antigens and the host cellular response. The third section deals with clinical aspects of transplantation, while the fourth looks toward future efforts of scientific research in this field—including advances in tolerance and xenotransplantation. A detailed appendix entitled "Molecular Biology for the Clinician" is included to help make the material accessible to readers of all backgrounds. Authored by a wide range of experts in both clinical and research fields, individual chapters cover such topics as: T cell immunity Antigen presentation Alloreactivity Pancreas and islet cell transplantation Allogeneic bone marrow transplantation Models of tolerance induction Xenotransplantation The swine leukocyte antigen (SLA) complex Transplantation Immunology is an ideal teaching text for the fundamental concepts, latest findings, and future directions in this increasingly important field. This volume will appeal to a wide range of clinicians including surgeons and primary-care physicians, as well as scientists in molecular biology and immunology.

Oncoimmunology

Oncoimmunology
Author: Laurence Zitvogel,Guido Kroemer
Publsiher: Springer
Total Pages: 724
Release: 2017-12-13
ISBN 10: 3319624318
ISBN 13: 9783319624310
Language: EN, FR, DE, ES & NL

Oncoimmunology Book Review:

In this book, leading experts in cancer immunotherapy join forces to provide a comprehensive guide that sets out the main principles of oncoimmunology and examines the latest advances and their implications for clinical practice, focusing in particular on drugs with FDA/EMA approvals and breakthrough status. The aim is to deliver a landmark educational tool that will serve as the definitive reference for MD and PhD students while also meeting the needs of established researchers and healthcare professionals. Immunotherapy-based approaches are now inducing long-lasting clinical responses across multiple histological types of neoplasia, in previously difficult-to-treat metastatic cancers. The future challenges for oncologists are to understand and exploit the cellular and molecular components of complex immune networks, to optimize combinatorial regimens, to avoid immune-related side effects, and to plan immunomonitoring studies for biomarker discovery. The editors hope that this book will guide future and established health professionals toward the effective application of cancer immunology and immunotherapy and contribute significantly to further progress in the field.

When the Mind Fails

When the Mind Fails
Author: Michel Silberfeld,Arthur Fish
Publsiher: University of Toronto Press
Total Pages: 482
Release: 1994-01-01
ISBN 10: 9780802067807
ISBN 13: 0802067808
Language: EN, FR, DE, ES & NL

When the Mind Fails Book Review:

Michel Silberfeld, a doctor, and Arthur Fish, a lawyer, draw on their experience at a competency clinic, citing fictional but realistic case studies and offering many concrete examples.

Veterinary Herbal Medicine

Veterinary Herbal Medicine
Author: Susan G. Wynn,Barbara Fougère
Publsiher: Elsevier Health Sciences
Total Pages: 714
Release: 2007
ISBN 10: 0323029981
ISBN 13: 9780323029988
Language: EN, FR, DE, ES & NL

Veterinary Herbal Medicine Book Review:

This full-color text and practical clinical reference provides comprehensive information on herbal remedies for both large and small animal species. Key coverage includes clinical uses of medicinal plants, specific information on how to formulate herbal remedies, a systems-based review of plant-based medicine, and in-depth information on the different animal species--dog, cat, avian and exotic, equine, food animal, and poultry.

The Journal of Immunology

The Journal of Immunology
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 2005
ISBN 10: 1928374650XXX
ISBN 13: UIUC:30112044620497
Language: EN, FR, DE, ES & NL

The Journal of Immunology Book Review:

Essentials of Clinical Immunology

Essentials of Clinical Immunology
Author: Helen Chapel,Mansel Haeney,Siraj Misbah,Neil Snowden
Publsiher: John Wiley & Sons
Total Pages: 376
Release: 2013-12-17
ISBN 10: 1118487877
ISBN 13: 9781118487877
Language: EN, FR, DE, ES & NL

Essentials of Clinical Immunology Book Review:

Essentials of Clinical Immunology provides the most up-to-date, core information required to understand diseases with an immunological basis. Clinically focussed, the sixth edition of this classic text presents theoretical and practical information in a simple yet thorough way. Essentials of Clinical Immunology covers the underlying pathophysiology, the signs and symptoms of disease, the investigations required and guidance on the management of patients. Perfect for clinical medical students, junior doctors and medical professionals seeking a refresher in the role of immunology in clinical medicine, this comprehensive text features fully updated clinical information, boxes with key points, real-life case histories to illustrate key concepts and an index of contents at the start of each chapter. A companion website at www.immunologyclinic.com provides additional learning tools, including more case studies, interactive multiple-choice questions and answers, all of the photographs and illustrations from the book, links to useful websites, and a selection of review articles from the journal Clinical and Experimental Immunology. This title is also available as a mobile App from MedHand Mobile Libraries. Buy it now from iTunes, Google Play or the MedHand Store.