Bone Cancer

Bone Cancer
Author: Dominique Heymann
Publsiher: Academic Press
Total Pages: 1078
Release: 2021-09-23
ISBN 10: 0323899900
ISBN 13: 9780323899901
Language: EN, FR, DE, ES & NL

Bone Cancer Book Review:

Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside, Third Edition comprehensively investigates key discoveries in the field of bone biology. New aspects of bone cancer biology are treated in new chapters covering exosomes, autophagy, and metabolism. These have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Third Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with 40% new material. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for everyone within the medical and cancer research communities. Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside continues to offer the only translational reference to cover all aspects of primary bone cancer and bone metastases. This revision opens the door to myeloma with two short chapters dedicated to this bone-associated disease. Covers the broad field of bone sarcomas and bone metastases from basic research to clinical approaches Presents comprehensive and translational overview of biological and clinical aspects of bone cancers, discussing pathophysiology from genetic and molecular levels using the most recent evidence Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system Offers insights to research clinicians (oncologists and radiologists) into understanding the molecular basis of bone cancer, leading to more well-informed diagnoses and treatment of tumors and metastases Offers insights to bone biologists into how clinical observations and practices can feed back into the research cycle and, therefore, can contribute to the development of more targeted genomic and proteomic assays

Biomaterials for 3D Tumor Modeling

Biomaterials for 3D Tumor Modeling
Author: Subhas C. Kundu,Rui L Reis
Publsiher: Elsevier
Total Pages: 772
Release: 2020-08-22
ISBN 10: 012818129X
ISBN 13: 9780128181294
Language: EN, FR, DE, ES & NL

Biomaterials for 3D Tumor Modeling Book Review:

Biomaterials for 3D Tumor Modeling reviews the fundamentals and most relevant areas of the latest advances of research of 3D cancer models, focusing on biomaterials science, tissue engineering, drug delivery and screening aspects. The book reviews advanced fundamental topics, including the causes of cancer, existing cancer models, angiogenesis and inflammation during cancer progression, and metastasis in 3D biomaterials. Then, the most relevant biomaterials are reviewed, including methods for engineering and fabrication of biomaterials. 3D models for key biological systems and types of cancer are also discussed, including lung, liver, oral, prostate, pancreatic, ovarian, bone and pediatric cancer. This book is suitable for those working in the disciplines of materials science, biochemistry, genetics, molecular biology, drug delivery and regenerative medicine. Reviews key biomaterials topics, including synthetic biomaterials, hydrogels, e-spun materials and nanoparticles Provides a comprehensive overview of 3D cancer models for key biological systems and cancer types Includes an overview of advanced fundamental concepts for an interdisciplinary audience in materials science, biochemistry, regenerative medicine and drug delivery

Clinical Atlas of 3D Printing Bone Reconstruction

Clinical Atlas of 3D Printing Bone Reconstruction
Author: Hyun-Guy Kang
Publsiher: Springer Nature
Total Pages: 442
Release: 2021-06-12
ISBN 10: 9811620431
ISBN 13: 9789811620430
Language: EN, FR, DE, ES & NL

Clinical Atlas of 3D Printing Bone Reconstruction Book Review:

This book provides practitioners with comprehensive guidance on the application of 3D printing technology in the bone reconstruction. The 3D printed implants need to be able to maximize function and minimize complications by reinforcing strength and changing shape beyond anatomically identical design. Many of the clinical cases in this book, including pre-operative images, surgical planning, design and fabrication, 3D printing implants and guides, surgery and postoperative images, will suffice to capture the sensation of the 3D printing bone reconstruction. This book is composed of photos with minimum descriptions so that the readers can develop their imaginative view.

Encyclopedia of Cancer

Encyclopedia of Cancer
Author: Anonim
Publsiher: Academic Press
Total Pages: 1841
Release: 2018-10-12
ISBN 10: 0128124857
ISBN 13: 9780128124857
Language: EN, FR, DE, ES & NL

Encyclopedia of Cancer Book Review:

Encyclopedia of Cancer, Third Edition provides a comprehensive, up-to-date overview of the multiple facets of the disease, including research, treatment and societal impact. This new edition comprises 180 contributions from renown experts who present the latest in Mechanisms, Hallmarks of Cancer, Causes of Cancer, Prevention and Control, Diagnosis and Therapy, Pathology and the Genetics of specific Cancers. Readers will find a comprehensive overview of the main areas of oncology, including etiology, mechanisms, prevention, and treatments, from basic science to clinical applications and public health, all set alongside the latest advances and hot topics that have emerged since the previous edition. Topics of interest in the field, including genomics and epigenomics, our understanding of the causes of cancer and the approaches to preventing it (e.g., HPV vaccination, role of obesity and nutrition, molecular markers of environmental exposures), new screening techniques (e.g., low-dose CT for lung cancer) and improvements in the treatment of many cancers (e.g., breast cancer, lung adenocarcinoma) are comprehensively and authoritatively presented. Comprises 180 contributions from renowned experts who present the latest in mechanisms, hallmarks of cancer, causes, prevention and control, diagnosis and therapy, pathology and genetics Presents a comprehensive overview of the main areas of oncology, including etiology, mechanisms, prevention, and treatments, from basic science to clinical applications and public health

The Definitive Guide to Cancer 3rd Edition

The Definitive Guide to Cancer  3rd Edition
Author: Lise N. Alschuler,Karolyn A. Gazella
Publsiher: Celestial Arts
Total Pages: 496
Release: 2012-11-20
ISBN 10: 0307814874
ISBN 13: 9780307814876
Language: EN, FR, DE, ES & NL

The Definitive Guide to Cancer 3rd Edition Book Review:

This comprehensive guide delivers informed hope along with effective tools for reclaiming your vitality in the midst of cancer treatment, healing, and recovery. When you or a loved one is faced with a cancer diagnosis, the need for accurate and trusted medical information becomes urgent. Naturopathic physician Lise N. Alschuler and medical journalist Karolyn A. Gazella present an overview of what cancer is, its causes and preventative strategies, an in-depth approach to integrative treatment options, descriptions of key body functions, and discussions of more than twenty specific cancers. The Definitive Guide to Cancer, now in its third edition, encourages you to take an integrative approach that embraces both alternative and conventional therapies across the spectrum of cancer prevention, treatment, and healing.

Bone Cancer

Bone Cancer
Author: Dominique Heymann
Publsiher: Elsevier
Total Pages: 736
Release: 2014-09-04
ISBN 10: 0124167284
ISBN 13: 9780124167285
Language: EN, FR, DE, ES & NL

Bone Cancer Book Review:

Bone Cancer, Second Edition comprehensively investigates key discoveries in the field of bone biology over the last five years that have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Second Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with key chapters from the first edition, and offers numerous new chapters describing the new concepts of bone cancer biology and therapy, for both primary bone tumors as well as bone metastases. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for everyone within the medical and cancer research communities. Bone Cancer continues to offer the only translational reference to cover all aspects of primary bone cancer and bone metastases – from bench to bedside: development (cellular and molecular mechanisms), genomic and proteomic analyses, clinical analyses (histopathology, imaging, pain monitoring), as well as new therapeutic approaches and clinical trials for primary bone tumors and bone metastases. Presents a comprehensive, translational source for all aspects of primary bone cancer and bone metastases in one reference work Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system Offers insights to research clinicians (oncologists and radiologists) into understanding the molecular basis of bone cancer, leading to more well-informed diagnoses and treatment of tumors and metastases Offers insights to bone biologists into how clinical observations and practices can feed back into the research cycle and, therefore, can contribute to the development of more targeted genomic and proteomic assays

Development of a 3D Microenvironment for Human Bone Metastasis

Development of a 3D Microenvironment for Human Bone Metastasis
Author: Antone Nour
Publsiher: Unknown
Total Pages: 135
Release: 2021
ISBN 10: 1928374650XXX
ISBN 13: OCLC:1291127306
Language: EN, FR, DE, ES & NL

Development of a 3D Microenvironment for Human Bone Metastasis Book Review:

"Bone is a dynamic tissue maintained through remodeling whereby it is constantly broken down and repaired through an equilibrium of osteoclast and osteoblast activity. However, when various cancers invade the bone, they disrupt this balance, leading to harmful bone structure and function changes. Radiotherapy, chemotherapy, and surgical resection are the main clinical approaches to bone metastases. Studying cancer cells in vitro relies on 2D monolayer cultures, which in no way represents the physiological tissue microenvironment in vivo. Therefore, preclinical and translational cancer research trends move toward organoid studies and 3D biomimetic models to provide more clinical relevance. Here, we set out to generate a bioink consisting of alginate, gelatin, and nanocrystal hydroxyapatite loaded with primary human osteoblasts and MSCs to produce a robust 3D bone-like microenvironment to study human bone metastasis. A hydrogel (3% alginate; 7% gelatin) model for cancer cell migration was modified to incorporate nanocrystal hydroxyapatite, primary human osteoblasts, and primary human bone marrow-derived stromal cells. Primary osteoblasts were isolated from vertebral bodies of organ donors, and bone marrow MSCs were purchased from Rooster Bio. The constructs were cultured over 28 days in a control medium (DMEM) or osteogenic medium (OM) with and without 0.5 mg/mL nano-hydroxyapatite (HA). Live/Dead® assays were performed to quantify viability, fixed frozen sections were stained with Alizarin Red for calcified matrix deposition, and Mayer's Hematoxylin and Eosin (H&E) staining to observe cells nuclei. High osteoblast viability in all conditions was observed after 28 days of culture: 92.5 ± 2.5 % for DMEM/HA-, 85.9 ± 6.2 % for OM/HA-, 91.3 ± 3.18 % for DMEM/HA+ and 88.6 ± 0.38 % for OM/HA+ respectively. MSCs were cultured for 21 days and showed 71.93 ± 4.59 % for DMEM/HA-, 68.56 ± 5.84 % for OM/HA-, 63.46 ± 4.78 % for DMEM/HA+ and 63.40 ± 1.16 % for OM/HA+. Moreover, cells grown in DMEM without HA had the least amount of mineralized bone matrix. Cells grown in OM/HA+ were found to have the most bone mineralized matrix. Our data indicate that the combination of 0.5 mg/mL nano-hydroxyapatite with OM produces a favorable bone-like microenvironment for primary human osteoblasts and MSCs. Our preliminary work with low-cost bioprinting indicates that this bioink is extrudable and will be ideal for screening therapeutics against patient-derived tumor cells. This work will allow a better understanding of interactions between normal osteoblasts, stromal cells, osteocytes, and patient-derived bone metastatic cells while also placing higher clinical relevance on therapeutics screening"--

Computer Assisted Musculoskeletal Surgery

Computer Assisted Musculoskeletal Surgery
Author: Lucas E. Ritacco,Federico E. Milano,Edmund Chao
Publsiher: Springer
Total Pages: 326
Release: 2015-11-02
ISBN 10: 3319129430
ISBN 13: 9783319129433
Language: EN, FR, DE, ES & NL

Computer Assisted Musculoskeletal Surgery Book Review:

​Computer-Assisted Surgery (CAS) is a new tool for performing complex procedures in a predictable and safe way. This book is designed to serve as a comprehensive review of Computer-Assisted Surgery, covering the current status of both research and applications. CAS includes Virtual Preoperative Planning (VPP) and Intraoperative Virtual Navigation (IVN), which are a set of technologies used to measure oncological margins in 3-Dimensions (3D), to locate small intraosseous tumors and apply controlled resections preserving anatomical structures. During VPP, patient acquired multimodal images are processed and an interactive virtual scenario is created. This can then be used as a platform to measure oncological distances and preplan osteotomies in safe areas. IVN is a procedure which allows the execution of the VPP with a mean error of less than 3mm. For the student, medical doctors, research and development scientists or new researchers, the protocols are central to the performance of Computer-Assisted technologies.

Vitamin D

Vitamin D
Author: David Feldman,J. Wesley Pike,Francis H. Glorieux
Publsiher: Elsevier
Total Pages: 1952
Release: 2005-01-25
ISBN 10: 0080543642
ISBN 13: 9780080543642
Language: EN, FR, DE, ES & NL

Vitamin D Book Review:

Vitamin D, a steroid hormone, has mainly been known for its effects on bone and osteoporosis. The current therapeutic practices expand into such markets as cancer research, pediatrics, nephrology, dermatology, immunology, and genetics. This second edition includes over 100 chapters covering everything from chemistry and metabolism to mechanisms of action, diagnosis and management, new analogs, and emerging therapies. This complete reference works is a must have resource for anyone working in endocrinology, osteology, bone biology, or cancer research. *Most comprehensive, up-to-date two-volume set on Vitamin D *New chapters on squamous cell cancer, brain cancer, thyroid cancer and many more *Further sections on emerging uses for treatments of auto-immune diseases and diabetes *Over 600 illustrations and figures available on CD

Human Ex Vivo 3d Bone Metastasis Model Recapitulates Osteocyte Response to Prostate Cancer Cells

Human Ex Vivo 3d Bone Metastasis Model Recapitulates Osteocyte Response to Prostate Cancer Cells
Author: Saba Choudhary
Publsiher: Unknown
Total Pages: 88
Release: 2018
ISBN 10: 9780438241718
ISBN 13: 0438241711
Language: EN, FR, DE, ES & NL

Human Ex Vivo 3d Bone Metastasis Model Recapitulates Osteocyte Response to Prostate Cancer Cells Book Review:

3D Bioprinting for Reconstructive Surgery

3D Bioprinting for Reconstructive Surgery
Author: Daniel Thomas,Zita M. Jessop,Iain S. Whitaker
Publsiher: Woodhead Publishing
Total Pages: 450
Release: 2017-11-14
ISBN 10: 0081012160
ISBN 13: 9780081012161
Language: EN, FR, DE, ES & NL

3D Bioprinting for Reconstructive Surgery Book Review:

3D Bioprinting for Reconstructive Surgery: Techniques and Applications examines the combined use of materials, procedures and tools necessary for creating structural tissue constructs for reconstructive purposes. Offering a broad analysis of the field, the first set of chapters review the range of biomaterials which can be used to create 3D-printed tissue constructs. Part Two looks at the techniques needed to prepare biomaterials and biological materials for 3D printing, while the final set of chapters examines application-specific examples of tissues formed from 3D printed biomaterials. 3D printing of biomaterials for tissue engineering applications is becoming increasingly popular due to its ability to offer unique, patient-specific parts—on demand—at a relatively low cost. This book is a valuable resource for biomaterials scientists, biomedical engineers, practitioners and students wishing to broaden their knowledge in the allied field. Discusses new possibilities in tissue engineering with 3D printing Presents a comprehensive coverage of the materials, techniques and tools needed for producing bioprinted tissues Reviews emerging technologies in addition to commercial techniques

Cancer Epidemiology and Prevention

Cancer Epidemiology and Prevention
Author: Michael Thun,Martha S. Linet,James R. Cerhan,Christopher A. Haiman,David Schottenfeld
Publsiher: Oxford University Press
Total Pages: 1336
Release: 2017-11-14
ISBN 10: 0190238666
ISBN 13: 9780190238667
Language: EN, FR, DE, ES & NL

Cancer Epidemiology and Prevention Book Review:

Since its initial publication in 1982, CANCER EPIDEMIOLOGY AND PREVENTION has served as the premier reference work for students and professionals working to understand the causes and prevention of cancer in humans. Now revised for the first time in more than a decade, this fourth edition provides a comprehensive summary of the global patterns of cancer incidence and mortality, current understanding of the major causal determinants, and a rationale for preventive interventions. Special attention is paid tomolecular epidemiologic approaches that address the wider role of genetic predisposition and gene-environment interactions in cancer etiology and pathogenesis. New and timely chapters on environmental and social-epidemiologic factors include: * The role of social class disparities* The role of obesity and physical inactivity* The potential effects of electromagnetic fields and radiofrequency radiation* The principles of cancer chemopreventionFor both seasoned professionals and newer generations of students and researchers, this fourth edition of CANCER EPIDEMIOLOGY AND PREVENTION remains the authority in the field - a work of distinction that every lab, library, student, professional, or researcher should have close at hand.

Breast Tomosynthesis E Book

Breast Tomosynthesis E Book
Author: Liane E Philpotts,Regina J Hooley
Publsiher: Elsevier Health Sciences
Total Pages: 350
Release: 2016-11-02
ISBN 10: 0323377459
ISBN 13: 9780323377454
Language: EN, FR, DE, ES & NL

Breast Tomosynthesis E Book Book Review:

The use of tomosynthesis in breast imaging is growing rapidly due to its superior ability to identify and characterize normal findings, benign lesions, and breast cancer, as well as its optimal performance with dense breast tissue. Providing unparalleled coverage of this breakthrough breast imaging modality, Breast Tomosynthesis explains how this new modality can lead to enhanced interpretation and better patient outcomes. This new reference is an indispensable guide for today's practitioner looking to keep abreast of the latest developments with correlative findings, practical interpretation tips, physics, and information on how tomosynthesis differs from conventional 2D FFDM mammography. Over 900 high-quality images offer visual guidance to effectively reading and interpreting this key imaging modality. Includes over 900 high-quality tomosynthesis and mammography images representing the spectrum of breast imaging. Features the latest Breast Imaging Reporting and Data System (or BI-RADS) standards updated in February 2014. Highlights practical tips to interpreting this new modality and how it differs from 2D mammography. Details how integration of tomosynthesis drastically changes lesion work-up and overall workflow in the department. "Tomo Tips" boxes offer tips and pitfalls for expert clinical guidance.

Textbook of Palliative Medicine

Textbook of Palliative Medicine
Author: Eduardo Bruera,Irene Higginson,Charles F von Gunten
Publsiher: CRC Press
Total Pages: 1024
Release: 2009-01-30
ISBN 10: 0340966246
ISBN 13: 9780340966242
Language: EN, FR, DE, ES & NL

Textbook of Palliative Medicine Book Review:

Textbook of Palliative Medicine provides an alternative, truly international approach to this rapidly growing specialty. This textbook fills a niche with its evidence-based, multi-professional approach and global perspective ensured by the international team of editors and contributing authors. In the absence of an international curriculum for the study of palliative medicine, this textbook provides essential guidance for those both embarking upon a career in palliative medicine or already established in the field, and the structure and content have been constructed very much with this in mind. With an emphasis on providing a service anywhere in the world, including the important issue of palliative care in the developing nations, Textbook of Palliative Medicine offers a genuine alternative to the narrative approach of its competitors, and is an ideal complement to them. It is essential reading for all palliative care physicians in training and in practice, as well as palliative care nurses and other health professionals in the palliative care team

Lancaster City and County Politics

Lancaster City and County Politics
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 1922
ISBN 10: 1928374650XXX
ISBN 13: OCLC:530461473
Language: EN, FR, DE, ES & NL

Lancaster City and County Politics Book Review:

Lancaster City and County Politics gives an unusual perspective of the area's politics. Newspaper articles representing both the Republican Party and Democratic Party develop the unique look. It also contains information about women's involvement in politics. Local, state and federal government branches are all discussed in the book. There are also articles about the major political issues in 1922, such as prohibition, daylight savings time, and education funding. Individuals mentioned in the scrapbooks include John A. McSparran, William Johnson, Scott W. Baker, Gifford Pinchot, W. W. Greist, W. D. Marburger, Samuel E. Shull, Frank Musser, and Milton T. Garvin.

Bone Cancer

Bone Cancer
Author: Dominique Heymann
Publsiher: Academic Press
Total Pages: 504
Release: 2009-08-20
ISBN 10: 9780080953885
ISBN 13: 0080953883
Language: EN, FR, DE, ES & NL

Bone Cancer Book Review:

The epidemiological and clinical importance of bone metastasis has long been recognized, but the past decade has seen an explosion in the fields of bone biology and bone cancer research. This period of time has been marked by a number of key discoveries that have led to the opening up of entirely new areas for investigation as well as new therapies which combine surgery and biological therapeutic approaches. Bone is a common site of cancer metastases - cancer cells commonly develop in bone and spread to other organ systems through the bloodstream. For example, the incidence of bone metastases in breast and prostate cancers is 70%, whereas it is only 30 to 40% in metastatic lung cancer. In clinical terms, bone metastases have substantial negative effects on a patient's quality of life and are a main cause of patient mortality. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for the medical and cancer research communities. This book provides, all in one resource, the most recent data on bone cancer development (cellular and molecular mechanisms), genomic and proteomic analyses, clinical analyses (histopathology, imaging, pain monitoring), as well as new therapeutic approaches and clinical trials for primary bone tumors and bone metastases. Feature Presents a comprehensive, translational source for all aspects of bone cancer in one reference work Bone cancer experts (from all areas of research and practice) take readers from the bench research (cellular and molecular mechanism), through genomic and proteomic analysis, all the way to clinical analysis (histopathology and imaging) and new therapeutic approaches. Clear presentation by bone biologists of the cellular and molecular mechanisms underlying bone tumors and bone cancer metastasis as well as the genomic and proteomic assays used in detecting cancer within given organ systems Clear presentation by oncologists and radiologists of how histopathology, imaging, and pain monitoring can lead to new therapeutic approaches Benefit Saves researchers and clinicians time in quickly accessing the very latest details on a broad range of bone cancer issues, as opposed to searching through thousands of journal articles. Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system Correct diagnosis (and therefore correct treatment) of cancer depends on a strong understanding of the molecular basis for the disease – both oncologists and radiologists will benefit Bone biologists will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic and proteomic assays

Bone Marrow Adipose Tissue Formation Function and Impact on Health and Disease

Bone Marrow Adipose Tissue  Formation  Function  and Impact on Health and Disease
Author: William P. Cawthorn,Erica L. Scheller
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2017-08-15
ISBN 10: 288945245X
ISBN 13: 9782889452453
Language: EN, FR, DE, ES & NL

Bone Marrow Adipose Tissue Formation Function and Impact on Health and Disease Book Review:

Adipocytes are a major component of the bone marrow, accounting for up to 70% of total bone marrow volume in healthy humans. Indeed, this bone marrow adipose tissue (often referred to as ‘MAT’ or ‘BMAT’) accounts for at least 5% of total adipose tissue mass in lean, healthy humans, suggesting a role in normal physiology and development. Bone marrow adiposity further increases with ageing and in diverse clinical conditions, including major public health challenges such as osteoporosis. Yet despite this abundance and compelling clinical potential, bone marrow adipocytes have received surprisingly little attention from the biomedical research community. Thankfully, this is now beginning to change. Research over the past decade has begun to increase our knowledge of BMAT, including the conditions associated with altered bone marrow adiposity and the potential physiological and pathological functions of bone marrow adipocytes. The articles within this e-Book highlight many of these recent developments, underscoring our increasing knowledge of BMAT formation and function; showcasing emerging techniques for basic and clinical BMAT analysis; and highlighting key questions and future directions for this burgeoning and increasingly diverse field. The editors would like to express their thanks to the authors for contributing the articles within this e-Book; to the senior editors at Frontiers in Endocrinology for their guidance; and to the staff at Frontiers for their helpful input throughout.

Oxford Textbook of Oncology

Oxford Textbook of Oncology
Author: David J. Kerr,Daniel G. Haller,Cornelis J. H. van de Velde,Michael Baumann
Publsiher: Oxford University Press
Total Pages: 832
Release: 2016-01-28
ISBN 10: 0191065110
ISBN 13: 9780191065118
Language: EN, FR, DE, ES & NL

Oxford Textbook of Oncology Book Review:

Now in paperback, the Oxford Textbook of Oncology reflects current best practice in the multidisciplinary management of cancer, written and edited by internationally recognised leaders in the field. Structured in six sections, the book provides an accessible scientific basis to the key topics of oncology, examining how cancer cells grow and function, as well as discussing the aetiology of cancer, and the general principles governing modern approaches to oncology treatment. The book examines the challenges presented by the treatment of cancer on a larger scale within population groups, and the importance of recognising and supporting the needs of individual patients, both during and after treatment. A series of disease-oriented, case-based chapters, ranging from acute leukaemia to colon cancer, highlight the various approaches available for managing the cancer patient, including the translational application of cancer science in order to personalise treatment. The advice imparted in these cases has relevance worldwide, and reflects a modern approach to cancer care. The Oxford Textbook of Oncology provides a comprehensive account of the multiple aspects of best practice in the discipline, making it an indispensable resource for oncologists of all grades and subspecialty interests.

Essentials of Glycobiology

Essentials of Glycobiology
Author: Ajit Varki,Maarten J. Chrispeels
Publsiher: CSHL Press
Total Pages: 653
Release: 1999
ISBN 10: 9780879696818
ISBN 13: 0879696818
Language: EN, FR, DE, ES & NL

Essentials of Glycobiology Book Review:

Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

Tumor Organoids

Tumor Organoids
Author: Shay Soker,Aleksander Skardal
Publsiher: Humana Press
Total Pages: 213
Release: 2017-10-20
ISBN 10: 3319605119
ISBN 13: 9783319605111
Language: EN, FR, DE, ES & NL

Tumor Organoids Book Review:

Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.