Bone Cancer

Bone Cancer
Author: Dominique Heymann
Publsiher: Academic Press
Total Pages: 1078
Release: 2021-09-23
ISBN 10: 0323899900
ISBN 13: 9780323899901
Language: EN, FR, DE, ES & NL

Bone Cancer Book Review:

Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside, Third Edition comprehensively investigates key discoveries in the field of bone biology. New aspects of bone cancer biology are treated in new chapters covering exosomes, autophagy, and metabolism. These have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Third Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with 40% new material. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for everyone within the medical and cancer research communities. Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside continues to offer the only translational reference to cover all aspects of primary bone cancer and bone metastases. This revision opens the door to myeloma with two short chapters dedicated to this bone-associated disease. Covers the broad field of bone sarcomas and bone metastases from basic research to clinical approaches Presents comprehensive and translational overview of biological and clinical aspects of bone cancers, discussing pathophysiology from genetic and molecular levels using the most recent evidence Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system Offers insights to research clinicians (oncologists and radiologists) into understanding the molecular basis of bone cancer, leading to more well-informed diagnoses and treatment of tumors and metastases Offers insights to bone biologists into how clinical observations and practices can feed back into the research cycle and, therefore, can contribute to the development of more targeted genomic and proteomic assays

Tissue Engineered 3D in Vitro Bone Cancer Models for Elucidating Drivers of Cancer Progression and Drug Discovery

Tissue Engineered 3D in Vitro Bone Cancer Models for Elucidating Drivers of Cancer Progression and Drug Discovery
Author: Eva Carolina Gonzalez Diaz
Publsiher: Unknown
Total Pages: 0
Release: 2022
ISBN 10: 1928374650XXX
ISBN 13: OCLC:1342794533
Language: EN, FR, DE, ES & NL

Tissue Engineered 3D in Vitro Bone Cancer Models for Elucidating Drivers of Cancer Progression and Drug Discovery Book Review:

Malignant bone tumors are aggressive neoplasms which can arise from bone tissue or as a result of metastasis. The most prevalent types of cancer, such as breast cancer and prostate cancer, preferentially metastasize to bone, yet the role of the bone niche in promoting cancer progression is poorly understood. Tissue engineering tools have the potential to bridge this knowledge gap by providing 3D in vitro platforms that can be specifically designed to mimic key properties of the bone niche. However, most 3D models to date have been designed to mimic soft tissue tumors, which lack the unique matrix and cellular compositions of the bone niche. Here, we present our work on engineering 3D models of osteosarcoma (OS), an aggressive pediatric bone cancer for which treatments have seen little progress in over 30 years. Using microribbon (μRB) scaffolds with bone-mimicking compositions, we evaluated the role of 3D culture and hydroxyapatite in OS signaling and drug response. Our findings reveal hydroxyapatite in 3D was critical to support retention of OS signaling and drug resistance similar to patient tissues and mouse orthotopic tumors. Integrating 3D PDX OS models with RNA sequencing, we identified a 3D-specific druggable target for OS which predicted in vivo drug response. Together, our results demonstrate the potential of 3D μRB models to serve as novel experimental tools to enable discovery of new therapies for OS which would otherwise be missed in 2D screens. Bone is the most frequent site of metastasis in breast and prostate cancer, yet why cancer cells preferentially metastasize to the bones remains unknown. Furthermore, there are currently no effective treatments for bone metastases, highlighting a critical need to elucidate the mechanisms underlying bone metastasis development and establish tools to facilitate the discovery of new therapies. To address this unmet need, we developed 3D in vitro models of breast cancer and prostate cancer metastasis to bone using spatially patterned biomaterials that mimic the in vivo cancer cell interface with bone tissues. Our data demonstrate that spatially patterned, 3D models recapitulate the preferential migration of cancer cells into bone, cancer aggressiveness, and drug response consistent with in vivo models. Importantly, we show that such 3D models can recapitulate cancer-induced dysregulation of bone remodeling, a key pathological outcome in patients which leads to significant morbidity and mortality. Lastly, we demonstrate the potential of integrating spatially patterned 3D models with single-cell RNA sequencing to identify key signaling drivers of cancer metastasis to bone. Taken together, our findings establish spatially patterned 3D in vitro bone metastasis models as a promising platform to elucidate bone metastasis biology and expedite drug discovery.

Clinical Atlas of 3D Printing Bone Reconstruction

Clinical Atlas of 3D Printing Bone Reconstruction
Author: Hyun-Guy Kang
Publsiher: Springer Nature
Total Pages: 442
Release: 2021-06-12
ISBN 10: 9811620431
ISBN 13: 9789811620430
Language: EN, FR, DE, ES & NL

Clinical Atlas of 3D Printing Bone Reconstruction Book Review:

This book provides practitioners with comprehensive guidance on the application of 3D printing technology in the bone reconstruction. The 3D printed implants need to be able to maximize function and minimize complications by reinforcing strength and changing shape beyond anatomically identical design. Many of the clinical cases in this book, including pre-operative images, surgical planning, design and fabrication, 3D printing implants and guides, surgery and postoperative images, will suffice to capture the sensation of the 3D printing bone reconstruction. This book is composed of photos with minimum descriptions so that the readers can develop their imaginative view.

International Classification of Diseases for Oncology

International Classification of Diseases for Oncology
Author: World Health Organization Staff,World Health Organization,Andrew Jack,Constance L. Percy,L. Sobin,S. Whelan
Publsiher: World Health Organization
Total Pages: 252
Release: 2000
ISBN 10: 9789241545341
ISBN 13: 9241545348
Language: EN, FR, DE, ES & NL

International Classification of Diseases for Oncology Book Review:

This edition of ICD-O, the standard tool for coding diagnoses of neoplasms in tumour and cancer registrars and in pathology laboratories, has been developed by a working party convened by the International Agency for Research on Cancer / WHO. ICD-O is a dual classification with coding systems for both topography and morphology. The book has five main sections. The first provides general instructions for using the coding systems and gives rules for their implementation in tumour registries and pathology laboratories. Section two includes the numerical list of topography codes, which remain unchanged from the previous edition. The numerical list of morphology codes is presented in the next section, which introduces several new terms and includes considerable revisions of the non-Hodgkin lymphoma and leukaemia sections, based on the WHO Classification of Hematopoietic and Lympoid Diseases. The five-digit morphology codes allow identification of a tumour or cell type by histology, behaviour, and grade. Revisions in the morphology section were made in consultation with a large number of experts and were finalised after field-testing in cancer registries around the world. The alphabetical index gives codes for both topography and morphology and includes selected tumour-like lesions and conditions. A guide to differences in morphology codes between the second and third editions is provided in the final section, which includes lists of all new code numbers, new terms and synonyms added to existing code definitions, terms that changed morphology code, terms for conditions now considered malignant, deleted terms, and terms that changed behaviour code.

Symposium on Bone Tumors

Symposium on Bone Tumors
Author: Anonim
Publsiher: Unknown
Total Pages: 29
Release: 1970
ISBN 10: 1928374650XXX
ISBN 13: OCLC:10178494
Language: EN, FR, DE, ES & NL

Symposium on Bone Tumors Book Review:

The Definitive Guide to Cancer 3rd Edition

The Definitive Guide to Cancer  3rd Edition
Author: Lise N. Alschuler,Karolyn A. Gazella
Publsiher: Celestial Arts
Total Pages: 496
Release: 2012-11-20
ISBN 10: 0307814874
ISBN 13: 9780307814876
Language: EN, FR, DE, ES & NL

The Definitive Guide to Cancer 3rd Edition Book Review:

This comprehensive guide delivers informed hope along with effective tools for reclaiming your vitality in the midst of cancer treatment, healing, and recovery. When you or a loved one is faced with a cancer diagnosis, the need for accurate and trusted medical information becomes urgent. Naturopathic physician Lise N. Alschuler and medical journalist Karolyn A. Gazella present an overview of what cancer is, its causes and preventative strategies, an in-depth approach to integrative treatment options, descriptions of key body functions, and discussions of more than twenty specific cancers. The Definitive Guide to Cancer, now in its third edition, encourages you to take an integrative approach that embraces both alternative and conventional therapies across the spectrum of cancer prevention, treatment, and healing.

Development of a 3D Microenvironment for Human Bone Metastasis

Development of a 3D Microenvironment for Human Bone Metastasis
Author: Antone Nour
Publsiher: Unknown
Total Pages: 135
Release: 2021
ISBN 10: 1928374650XXX
ISBN 13: OCLC:1291127306
Language: EN, FR, DE, ES & NL

Development of a 3D Microenvironment for Human Bone Metastasis Book Review:

"Bone is a dynamic tissue maintained through remodeling whereby it is constantly broken down and repaired through an equilibrium of osteoclast and osteoblast activity. However, when various cancers invade the bone, they disrupt this balance, leading to harmful bone structure and function changes. Radiotherapy, chemotherapy, and surgical resection are the main clinical approaches to bone metastases. Studying cancer cells in vitro relies on 2D monolayer cultures, which in no way represents the physiological tissue microenvironment in vivo. Therefore, preclinical and translational cancer research trends move toward organoid studies and 3D biomimetic models to provide more clinical relevance. Here, we set out to generate a bioink consisting of alginate, gelatin, and nanocrystal hydroxyapatite loaded with primary human osteoblasts and MSCs to produce a robust 3D bone-like microenvironment to study human bone metastasis. A hydrogel (3% alginate; 7% gelatin) model for cancer cell migration was modified to incorporate nanocrystal hydroxyapatite, primary human osteoblasts, and primary human bone marrow-derived stromal cells. Primary osteoblasts were isolated from vertebral bodies of organ donors, and bone marrow MSCs were purchased from Rooster Bio. The constructs were cultured over 28 days in a control medium (DMEM) or osteogenic medium (OM) with and without 0.5 mg/mL nano-hydroxyapatite (HA). Live/Dead® assays were performed to quantify viability, fixed frozen sections were stained with Alizarin Red for calcified matrix deposition, and Mayer's Hematoxylin and Eosin (H&E) staining to observe cells nuclei. High osteoblast viability in all conditions was observed after 28 days of culture: 92.5 ± 2.5 % for DMEM/HA-, 85.9 ± 6.2 % for OM/HA-, 91.3 ± 3.18 % for DMEM/HA+ and 88.6 ± 0.38 % for OM/HA+ respectively. MSCs were cultured for 21 days and showed 71.93 ± 4.59 % for DMEM/HA-, 68.56 ± 5.84 % for OM/HA-, 63.46 ± 4.78 % for DMEM/HA+ and 63.40 ± 1.16 % for OM/HA+. Moreover, cells grown in DMEM without HA had the least amount of mineralized bone matrix. Cells grown in OM/HA+ were found to have the most bone mineralized matrix. Our data indicate that the combination of 0.5 mg/mL nano-hydroxyapatite with OM produces a favorable bone-like microenvironment for primary human osteoblasts and MSCs. Our preliminary work with low-cost bioprinting indicates that this bioink is extrudable and will be ideal for screening therapeutics against patient-derived tumor cells. This work will allow a better understanding of interactions between normal osteoblasts, stromal cells, osteocytes, and patient-derived bone metastatic cells while also placing higher clinical relevance on therapeutics screening"--

Biomaterials for 3D Tumor Modeling

Biomaterials for 3D Tumor Modeling
Author: Subhas C. Kundu,Rui L Reis
Publsiher: Elsevier
Total Pages: 772
Release: 2020-08-22
ISBN 10: 012818129X
ISBN 13: 9780128181294
Language: EN, FR, DE, ES & NL

Biomaterials for 3D Tumor Modeling Book Review:

Biomaterials for 3D Tumor Modeling reviews the fundamentals and most relevant areas of the latest advances of research of 3D cancer models, focusing on biomaterials science, tissue engineering, drug delivery and screening aspects. The book reviews advanced fundamental topics, including the causes of cancer, existing cancer models, angiogenesis and inflammation during cancer progression, and metastasis in 3D biomaterials. Then, the most relevant biomaterials are reviewed, including methods for engineering and fabrication of biomaterials. 3D models for key biological systems and types of cancer are also discussed, including lung, liver, oral, prostate, pancreatic, ovarian, bone and pediatric cancer. This book is suitable for those working in the disciplines of materials science, biochemistry, genetics, molecular biology, drug delivery and regenerative medicine. Reviews key biomaterials topics, including synthetic biomaterials, hydrogels, e-spun materials and nanoparticles Provides a comprehensive overview of 3D cancer models for key biological systems and cancer types Includes an overview of advanced fundamental concepts for an interdisciplinary audience in materials science, biochemistry, regenerative medicine and drug delivery

Encyclopedia of Cancer

Encyclopedia of Cancer
Author: Anonim
Publsiher: Academic Press
Total Pages: 1841
Release: 2018-10-12
ISBN 10: 0128124857
ISBN 13: 9780128124857
Language: EN, FR, DE, ES & NL

Encyclopedia of Cancer Book Review:

Encyclopedia of Cancer, Third Edition provides a comprehensive, up-to-date overview of the multiple facets of the disease, including research, treatment and societal impact. This new edition comprises 180 contributions from renown experts who present the latest in Mechanisms, Hallmarks of Cancer, Causes of Cancer, Prevention and Control, Diagnosis and Therapy, Pathology and the Genetics of specific Cancers. Readers will find a comprehensive overview of the main areas of oncology, including etiology, mechanisms, prevention, and treatments, from basic science to clinical applications and public health, all set alongside the latest advances and hot topics that have emerged since the previous edition. Topics of interest in the field, including genomics and epigenomics, our understanding of the causes of cancer and the approaches to preventing it (e.g., HPV vaccination, role of obesity and nutrition, molecular markers of environmental exposures), new screening techniques (e.g., low-dose CT for lung cancer) and improvements in the treatment of many cancers (e.g., breast cancer, lung adenocarcinoma) are comprehensively and authoritatively presented. Comprises 180 contributions from renowned experts who present the latest in mechanisms, hallmarks of cancer, causes, prevention and control, diagnosis and therapy, pathology and genetics Presents a comprehensive overview of the main areas of oncology, including etiology, mechanisms, prevention, and treatments, from basic science to clinical applications and public health

Bone Cancer

Bone Cancer
Author: Dominique Heymann
Publsiher: Elsevier
Total Pages: 736
Release: 2014-09-04
ISBN 10: 0124167284
ISBN 13: 9780124167285
Language: EN, FR, DE, ES & NL

Bone Cancer Book Review:

Bone Cancer, Second Edition comprehensively investigates key discoveries in the field of bone biology over the last five years that have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Second Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with key chapters from the first edition, and offers numerous new chapters describing the new concepts of bone cancer biology and therapy, for both primary bone tumors as well as bone metastases. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for everyone within the medical and cancer research communities. Bone Cancer continues to offer the only translational reference to cover all aspects of primary bone cancer and bone metastases – from bench to bedside: development (cellular and molecular mechanisms), genomic and proteomic analyses, clinical analyses (histopathology, imaging, pain monitoring), as well as new therapeutic approaches and clinical trials for primary bone tumors and bone metastases. Presents a comprehensive, translational source for all aspects of primary bone cancer and bone metastases in one reference work Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system Offers insights to research clinicians (oncologists and radiologists) into understanding the molecular basis of bone cancer, leading to more well-informed diagnoses and treatment of tumors and metastases Offers insights to bone biologists into how clinical observations and practices can feed back into the research cycle and, therefore, can contribute to the development of more targeted genomic and proteomic assays

Human Ex Vivo 3d Bone Metastasis Model Recapitulates Osteocyte Response to Prostate Cancer Cells

Human Ex Vivo 3d Bone Metastasis Model Recapitulates Osteocyte Response to Prostate Cancer Cells
Author: Saba Choudhary
Publsiher: Unknown
Total Pages: 88
Release: 2018
ISBN 10: 9780438241718
ISBN 13: 0438241711
Language: EN, FR, DE, ES & NL

Human Ex Vivo 3d Bone Metastasis Model Recapitulates Osteocyte Response to Prostate Cancer Cells Book Review:

Development of an Approach to Increase Drug Uptake to Bone Tumors Using Non invasive Mechanical Loading

Development of an Approach to Increase Drug Uptake to Bone Tumors Using Non invasive Mechanical Loading
Author: Paolo E. Palacio,City University of New York. City College
Publsiher: Unknown
Total Pages: 110
Release: 2011
ISBN 10: 1928374650XXX
ISBN 13: OCLC:883630012
Language: EN, FR, DE, ES & NL

Development of an Approach to Increase Drug Uptake to Bone Tumors Using Non invasive Mechanical Loading Book Review:

This thesis develops an approach to enhance drug delivery to bone tumors by implementing a non-invasive mechanical loading technique. An imaging protocol that characterizes the load-enhanced drug uptake is also presented. The long-term goal of this work is to develop a clinical protocol that enhances the delivery of therapeutic agents to bone tumors by utilizing load-bearing activity. This easy-to-implement approach could help increase drug uptake into the tumor interstitial fluid space as well as into tumor cells, thereby enhancing a drug's clinical effect while decreasing systemic drug dosage and unwanted side effects. This thesis details the process used to grow cancer cells, induce tumors in a rat model, measure tumor development, inject a radioactive tracer, apply mechanical loading non-invasively, and image and quantify drug uptake distribution in bone tumors. Assessment of 99mTc-labeled pamidronate uptake was completed in vivo using planar microSPECT (2D gamma camera scans) employing a rat model of bone metastases. The pilot study using this methodology demonstrated that non-invasive mechanical loading enhanced drug delivery to cancerous tibial tumors by 34% when compared to contralateral non-loaded, non-tumor bearing tibiae. Several improvements to this approach have been developed including 1) improved cancer cell viability after injection, 2) enhancement of cancer cell inoculation by arthrotomy surgery instead of direct tibial injection, 3) shifting from gamma camera to 3D microPET imaging, 4) use of tumor-bearing tibiae as controls, 5) use of the clinically relevant Herceptin as the injected drug, and 6) implementation of high-resolution microCT and histology to assess bone destruction from tumor growth. If additional studies in the rat model using these improved techniques demonstrate load-induced enhancement of drug delivery, the approach will be attempted in the clinic. Clinical studies will implement exercise and/or non-invasive mechanical activity to enhance drug delivery. If successful, this approach would result in an improvement in the quality of life of patients suffering from bone cancer.

Breast Tomosynthesis E Book

Breast Tomosynthesis E Book
Author: Liane E Philpotts,Regina J Hooley
Publsiher: Elsevier Health Sciences
Total Pages: 350
Release: 2016-11-02
ISBN 10: 0323377459
ISBN 13: 9780323377454
Language: EN, FR, DE, ES & NL

Breast Tomosynthesis E Book Book Review:

The use of tomosynthesis in breast imaging is growing rapidly due to its superior ability to identify and characterize normal findings, benign lesions, and breast cancer, as well as its optimal performance with dense breast tissue. Providing unparalleled coverage of this breakthrough breast imaging modality, Breast Tomosynthesis explains how this new modality can lead to enhanced interpretation and better patient outcomes. This new reference is an indispensable guide for today's practitioner looking to keep abreast of the latest developments with correlative findings, practical interpretation tips, physics, and information on how tomosynthesis differs from conventional 2D FFDM mammography. Over 900 high-quality images offer visual guidance to effectively reading and interpreting this key imaging modality. Includes over 900 high-quality tomosynthesis and mammography images representing the spectrum of breast imaging. Features the latest Breast Imaging Reporting and Data System (or BI-RADS) standards updated in February 2014. Highlights practical tips to interpreting this new modality and how it differs from 2D mammography. Details how integration of tomosynthesis drastically changes lesion work-up and overall workflow in the department. "Tomo Tips" boxes offer tips and pitfalls for expert clinical guidance.

Breast Cancer Metastasis and Drug Resistance

Breast Cancer Metastasis and Drug Resistance
Author: Aamir Ahmad
Publsiher: Springer Nature
Total Pages: 427
Release: 2019-08-27
ISBN 10: 3030203018
ISBN 13: 9783030203016
Language: EN, FR, DE, ES & NL

Breast Cancer Metastasis and Drug Resistance Book Review:

Resistance to therapies, both targeted and systemic, and metastases to distant organs are the underlying causes of breast cancer-associated mortality. The second edition of Breast Cancer Metastasis and Drug Resistance brings together some of the leading experts to comprehensively understand breast cancer: the factors that make it lethal, and current research and clinical progress. This volume covers the following core topics: basic understanding of breast cancer (statistics, epidemiology, racial disparity and heterogeneity), metastasis and drug resistance (bone metastasis, trastuzumab resistance, tamoxifen resistance and novel therapeutic targets, including non-coding RNAs, inflammatory cytokines, cancer stem cells, ubiquitin ligases, tumor microenvironment and signaling pathways such as TRAIL, JAK-STAT and mTOR) and recent developments in the field (epigenetic regulation, microRNAs-mediated regulation, novel therapies and the clinically relevant 3D models). Experts also discuss the advances in laboratory research along with their translational and clinical implications with an overarching goal to improve the diagnosis and prognosis, particularly that of breast cancer patients with advanced disease.

Vitamin D

Vitamin D
Author: David Feldman,J. Wesley Pike,Francis H. Glorieux
Publsiher: Elsevier
Total Pages: 1952
Release: 2005-01-25
ISBN 10: 0080543642
ISBN 13: 9780080543642
Language: EN, FR, DE, ES & NL

Vitamin D Book Review:

Vitamin D, a steroid hormone, has mainly been known for its effects on bone and osteoporosis. The current therapeutic practices expand into such markets as cancer research, pediatrics, nephrology, dermatology, immunology, and genetics. This second edition includes over 100 chapters covering everything from chemistry and metabolism to mechanisms of action, diagnosis and management, new analogs, and emerging therapies. This complete reference works is a must have resource for anyone working in endocrinology, osteology, bone biology, or cancer research. *Most comprehensive, up-to-date two-volume set on Vitamin D *New chapters on squamous cell cancer, brain cancer, thyroid cancer and many more *Further sections on emerging uses for treatments of auto-immune diseases and diabetes *Over 600 illustrations and figures available on CD

Textbook of Palliative Medicine

Textbook of Palliative Medicine
Author: Eduardo Bruera,Irene Higginson,Charles F von Gunten
Publsiher: CRC Press
Total Pages: 1024
Release: 2009-01-30
ISBN 10: 0340966246
ISBN 13: 9780340966242
Language: EN, FR, DE, ES & NL

Textbook of Palliative Medicine Book Review:

Textbook of Palliative Medicine provides an alternative, truly international approach to this rapidly growing specialty. This textbook fills a niche with its evidence-based, multi-professional approach and global perspective ensured by the international team of editors and contributing authors. In the absence of an international curriculum for the study of palliative medicine, this textbook provides essential guidance for those both embarking upon a career in palliative medicine or already established in the field, and the structure and content have been constructed very much with this in mind. With an emphasis on providing a service anywhere in the world, including the important issue of palliative care in the developing nations, Textbook of Palliative Medicine offers a genuine alternative to the narrative approach of its competitors, and is an ideal complement to them. It is essential reading for all palliative care physicians in training and in practice, as well as palliative care nurses and other health professionals in the palliative care team

Tumor Organoids

Tumor Organoids
Author: Shay Soker,Aleksander Skardal
Publsiher: Humana Press
Total Pages: 213
Release: 2017-10-20
ISBN 10: 3319605119
ISBN 13: 9783319605111
Language: EN, FR, DE, ES & NL

Tumor Organoids Book Review:

Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.

Harrison s Hematology and Oncology 3E

Harrison s Hematology and Oncology  3E
Author: Dan L. Longo
Publsiher: McGraw Hill Professional
Total Pages: 135
Release: 2016-09-22
ISBN 10: 1259835820
ISBN 13: 9781259835827
Language: EN, FR, DE, ES & NL

Harrison s Hematology and Oncology 3E Book Review:

Hematology and Oncology – backed by the unmatched authority of Harrison’s A Doody's Core Title for 2019! Featuring a superb compilation of chapters related to hematology and oncology derived from Harrison’s Principles of Internal Medicine, Nineteenth Edition (including content from the acclaimed Harrison’s DVD, now available here in print), this concise, full-color clinical companion delivers the latest knowledge in the field backed by the scientific rigor and authority that have defined Harrison’s. You will find 57 chapters from more than 75 renowned editors and contributors in a carry-anywhere presentation that is ideal for the classroom, clinic, ward, or exam/certification preparation. Features: • Each chapter contains relevant information on the genetics, cell biology, pathophysiology, and treatment of specific disease entities • Chapters on hematopoiesis, cancer cell biology, and cancer prevention reflect the rapidly growing knowledge in these areas • Integration of pathophysiology with clinical management • High-yield board review questions make this text ideal for keeping current or preparing for the boards • Valuable appendix of laboratory values of clinical importance

Cancer Epidemiology and Prevention

Cancer Epidemiology and Prevention
Author: Michael Thun,Martha S. Linet,James R. Cerhan,Christopher A. Haiman,David Schottenfeld
Publsiher: Oxford University Press
Total Pages: 1336
Release: 2017-11-14
ISBN 10: 0190238666
ISBN 13: 9780190238667
Language: EN, FR, DE, ES & NL

Cancer Epidemiology and Prevention Book Review:

Since its initial publication in 1982, CANCER EPIDEMIOLOGY AND PREVENTION has served as the premier reference work for students and professionals working to understand the causes and prevention of cancer in humans. Now revised for the first time in more than a decade, this fourth edition provides a comprehensive summary of the global patterns of cancer incidence and mortality, current understanding of the major causal determinants, and a rationale for preventive interventions. Special attention is paid tomolecular epidemiologic approaches that address the wider role of genetic predisposition and gene-environment interactions in cancer etiology and pathogenesis. New and timely chapters on environmental and social-epidemiologic factors include: * The role of social class disparities* The role of obesity and physical inactivity* The potential effects of electromagnetic fields and radiofrequency radiation* The principles of cancer chemopreventionFor both seasoned professionals and newer generations of students and researchers, this fourth edition of CANCER EPIDEMIOLOGY AND PREVENTION remains the authority in the field - a work of distinction that every lab, library, student, professional, or researcher should have close at hand.

Withrow and MacEwen s Small Animal Clinical Oncology E Book

Withrow and MacEwen s Small Animal Clinical Oncology   E Book
Author: David M. Vail,Douglas Thamm,Julias Liptak
Publsiher: Elsevier Health Sciences
Total Pages: 864
Release: 2019-07-23
ISBN 10: 0323594972
ISBN 13: 9780323594974
Language: EN, FR, DE, ES & NL

Withrow and MacEwen s Small Animal Clinical Oncology E Book Book Review:

Considered the definitive reference on canine and feline oncology, Withrow & MacEwen's Small Animal Clinical Oncology, 6th Edition focuses on the most effective, cutting-edge techniques. This comprehensive textbook gives you a complete understanding of cancer in dogs and cats — what it is, how to diagnose it, and how to treat many of the most common cancers encountered in clinical practice today. The thoroughly updated sixth edition includes information on the complications of cancer, pain management, and the latest treatment modalities — preparing general practitioners to diagnose and treat pets rather than referring them to a specialist. With important updates on recently approved and in-development drugs, and new co-authors adding their own unique perspectives, this user-friendly text is a must-have resource for current, evidence-based therapeutic strategies on canine and feline oncology. Cutting-edge information on the complications of cancer, pain management, and the latest treatment modalities prepares you to diagnose and treat pets with cancer rather than refer cases to a specialist. Each contributor is a recognized expert in his or her specialty, reflecting the most current information by highly respected experts in the field of veterinary oncology. Full-color format provides you with accurate visual depictions of specific diseases and procedures, enhances visual appeal, and is used functionally in tables and boxes to highlight key information. A systems approach to the diagnosis and management of cancer facilitates access to information about the many malignancies affecting small animal patients. Discussion of compassion and supportive care for the management of pain, nutritional needs, and grief includes methods for handling the pet’s pain and nutritional complications as well as the pet owner’s grief when treatment is not successful. Comprehensive references at the end of each chapter and topic ensures you can be confident the information provided is accurate and up to date. Helpful drug formularies provide quick access to information on indications, toxicities, and recommended dosages for chemotherapeutic and analgesic drugs used in cancer treatment. Chemotherapy protocols are included when case studies prove clinical efficacy. Information on the best interventional techniques is quickly accessible all in one chapter. Nearly 400 color images provide accurate depictions of specific diseases and procedures. Focus on the most effective treatment options saves time by emphasizing proven treatment options that have been vetted by experts in the field. NEW! Expert co-authors and contributors bring a valuable perspective with research experience. NEW! Thoroughly UPDATED content includes important updates on recently approved and in-development veterinary cancer drugs, and critical advances in radiation delivery.