Biological Chirality

Biological Chirality
Author: Gyula Palyi
Publsiher: Academic Press
Total Pages: 268
Release: 2019-11-06
ISBN 10: 0128123389
ISBN 13: 9780128123386
Language: EN, FR, DE, ES & NL

Biological Chirality Book Review:

Biological Chirality describes this occurrence, its history, and early research around the topic. The work covers analytical methods for observing the phenomenon, providing current techniques and practice and discussing the asymmetric morphology of certain living organisms, such as the position of the heart and liver in humans and the exceptions to biological homochirality seen in D-Amino Acids. In addition, it explores the requirement of enantioselectivity prepared pharmaceuticals to address enantioselectivities biomolecules, a major challenge in today's organic chemistry. Finally, the work considers the possible origin of biological homochirality, as well as the outlook for future research in this area. Describes the history of biological chirality research, its possible origins, and future exploration areas Discusses asymmetric exceptions in morphology and D-Amino Acids Explores the critical implications of enantioselective biomolecules for preparative organic chemistry with a goal of developing effective pharmaceuticals

Progress in Biological Chirality

Progress in Biological Chirality
Author: Gyula Palyi,Claudia Zucchi,Luciano Caglioti
Publsiher: Elsevier
Total Pages: 444
Release: 2004-12-13
ISBN 10: 9780080474038
ISBN 13: 0080474039
Language: EN, FR, DE, ES & NL

Progress in Biological Chirality Book Review:

Following on from Advances in BioChirality, Progress in Biological Chirality provides a unique summary and review of the most recent developments in the field of biochirality. Living organisms use only one enantiomer of chiral molecules in the majority of biologically important processes. The exact origin and mechanisms for this surprising selectivity are not yet known. This book discusses current research aimed at identifying the scientific reasons that may contribute to this phenomenon. Progress in Biological Chirality takes an interdisciplinary approach to this exciting field, covering a wide range of topics, such as, theory, palaeontology and food technology, to name but a few. This book presents findings via a broad spectrum of scientific approaches making it an excellent overview of Biological Chirality, suitable for postgraduate students, practitioners and researchers in the field of chemistry, biochemistry, biology, palaeontology, and food science with an interest in Chirality. This book contains 32 chapters written by Authors, who are leading authorities in the field Presents the most recent research taking place in this highly challenging field Contains both reference material for the specialist and provides an overview for those who are interested in the fundamental problems of biology and chemistry

Chirality in Biological Nanospaces

Chirality in Biological Nanospaces
Author: Nilashis Nandi
Publsiher: CRC Press
Total Pages: 209
Release: 2011-07-27
ISBN 10: 1439840024
ISBN 13: 9781439840023
Language: EN, FR, DE, ES & NL

Chirality in Biological Nanospaces Book Review:

Chirality is widely studied and omnipresent in biological molecules. However, how the retention of enantiomeric forms persists in many life processes without racemization is still unclear, and the molecular understanding of the stringent chiral specificity in enzymatic reactions is sparse. An overview of the influence of chirality in driving reactions within enzymatic cavities, Chirality in Biological Nanospaces: Reactions in Active Sites covers: Influences of molecular chirality on the structure of the active site and network of interactions to drive reactions with improved speed, accuracy, and efficiency The conserved features of the organization of the active site structures of enzymes The intricate interplay of electrostatic, hydrophobic, and van der Waals interactions Interactions between the active site residues and the substrate molecules Despite being time-consuming and expensive, trial-and-error is often the primary method used to develop synthetic enzymes. This book describes methods that combine crystallographic studies with electronic structure-based computational analysis. These methods may lead to future elucidation of new drugs that can target biological active sites with better efficacy and can be used to design custom-made novel biocytes with improved efficiency.

Chiral Drugs

Chiral Drugs
Author: Guo-Qiang Lin,Qi-Dong You,Jie-Fei Cheng
Publsiher: John Wiley & Sons
Total Pages: 472
Release: 2011-08-08
ISBN 10: 9781118075630
ISBN 13: 1118075633
Language: EN, FR, DE, ES & NL

Chiral Drugs Book Review:

An integrated view of chiral drugs—from concept and synthesisto pharmaceutical properties Chirality greatly influences a drug's biological and pharmacological properties. In an effort to achieve more predictable results from chiral drugs, the Food and Drug Administration now requires that these medicines be as pure as possible, which places great demands on drug synthesis, purification, analysis, and testing. To assist researchers in acquiring the essential knowledge to meet these rigid guidelines, Chiral Drugs focuses on three vital chiral technologies—asymmetric synthesis, biocatalytic process, and chiral resolution—to offer details on the basic concepts, key developments, and recent trends in chiral drug discovery, along with: The history of chiral drugs development and industrial applications of chiral technologies A section listing twenty-five approved or advanced-trial chiral drugs that lists each drug name, chemical name and properties, a representative synthetic pathway, pharmacological characterizations, and references An interdisciplinary approach combining synthetic organic chemistry, medicinal chemistry, and pharmacology Nearly two-thirds of the drugs on today's market are chiral drugs. Reducing and eliminating their negative characteristics is an ongoing and serious challenge for the pharmaceutical industry. With its well-balanced approach to covering each important aspect of chirality, Chiral Drugs champions important strategies for tipping the medical scale in a positive direction for the production of more effective—and safer—drugs.

Asymmetric Synthesis with Chemical and Biological Methods

Asymmetric Synthesis with Chemical and Biological Methods
Author: Dieter Enders,Karl-Erich Jaeger
Publsiher: John Wiley & Sons
Total Pages: 445
Release: 2007-04-09
ISBN 10: 3527314733
ISBN 13: 9783527314737
Language: EN, FR, DE, ES & NL

Asymmetric Synthesis with Chemical and Biological Methods Book Review:

This volume provides insight into stoichiometric and catalytic reactions in the field of asymmetric synthesis with chemical and biological methods, focusing on the synthesis of natural and bioactive compounds, and both chemical and biological methods of catalysis. It includes investigation of biotechnical aspects also.

Advances in BioChirality

Advances in BioChirality
Author: C. Zucchi,L. Caglioti,Gyula Palyi
Publsiher: Elsevier
Total Pages: 407
Release: 1999-09-08
ISBN 10: 9780080526621
ISBN 13: 0080526624
Language: EN, FR, DE, ES & NL

Advances in BioChirality Book Review:

Chirality is a fundamental, persistent, but often overlooked feature of all living organisms on the molecular level as well as on the macroscopic scale. The high degree of preference for only one of two possible mirror image forms in Nature, often called biological homochirality is a puzzling, and not yet fully understood, phenomenon. This book covers biological homochirality from an interdisciplinary approach - contributions range from synthetic chemists, theoretical topologists and physicists, from palaeontologists and biologists to space scientists and representatives of the pharmaceutical and materials industries. Topics covered include - theory of biochirality, origins of biochirality, autocatalysis with amplification of chirality, macroscopic (present) biochirality, fossil records of chiral organisms - paleochirality, extraterrestrial origin of chirality, exceptions to the rule of biological homochirality, D-amino acids, chemical transfer of chirality, PV effects, and polarised radiation chemistry.

Chirality and Biological Activity of Drugs

Chirality and Biological Activity of Drugs
Author: Roger J. Crossley
Publsiher: CRC Press
Total Pages: 216
Release: 1995-09-11
ISBN 10: 9780849391408
ISBN 13: 0849391407
Language: EN, FR, DE, ES & NL

Chirality and Biological Activity of Drugs Book Review:

This book brings together the theoretical, commercial, and practical aspects of chirality and biological activity of drugs and acts as a ready reference for the effects of enantiomers of drug substances.

Organometallic Chirality

Organometallic Chirality
Author: Gyula Pályi,Claudia Zucchi,Luciano Caglioti
Publsiher: Mucchi Editore
Total Pages: 276
Release: 2008
ISBN 10: 8870004910
ISBN 13: 9788870004915
Language: EN, FR, DE, ES & NL

Organometallic Chirality Book Review:

Current Topics in Chirality

Current Topics in Chirality
Author: Takashiro Akitsu
Publsiher: BoD – Books on Demand
Total Pages: 196
Release: 2021-09-01
ISBN 10: 1839689536
ISBN 13: 9781839689536
Language: EN, FR, DE, ES & NL

Current Topics in Chirality Book Review:

Chirality is a concept related not only to organic chemistry but also to each field of natural science. Awareness of hierarchy is important for universal and comprehensive understanding. As such, this book examines myriad subjects related to chirality in chemistry and interdisciplinary applications. In contrast to the previous book, this new book about chirality includes contributions from authors in many fields of natural science, providing a wider overview. The book’s focus is chirality and organic chemistry, including synthesis and reactions.

Chiral Separations

Chiral Separations
Author: D. Stevenson,I.D. Wilson
Publsiher: Springer Science & Business Media
Total Pages: 206
Release: 2012-12-06
ISBN 10: 1461566347
ISBN 13: 9781461566342
Language: EN, FR, DE, ES & NL

Chiral Separations Book Review:

This volume represents the proceedings of a two-day international meeting on chiral chromatography held at the University of Surrey between 3-4 September 1987. The meeting was jointly organized by the Chromatographic SOCiety and the Robens Institute of the University of Surrey in response to the burgeoning interest in this rapid maturing field of chromatography. Nowhere is this interest more evident than in the agrochemical and pharmaceutical industries where the implications of different pharmacological and toxicological activity for the individual enantiomers present in a racemic drug ol" insecticide is an increasing area of concern. Developments in the area of chiral separations are at last beginning to provide SCientists with the necessary tools to study how animals and man handle racemates and relate their obseIVations to the obseIVed biological effects of these substances. The development of robust and Simple methods for the separation of enantiomers will therefore have a profound Impact on safety evaluation and drug design. The meeting proved to be very successful. with over 160 delegates from thirteen countries in Europe and America present to learn from the experiences of experts in the field of chiral chromatography and to hear about the latest developments. Hopefully. in future symposia on chiral separations at the University of Surrey.

Chirality in Drug Design and Development

Chirality in Drug Design and Development
Author: Indra K. Reddy,Reza Mehvar
Publsiher: CRC Press
Total Pages: 406
Release: 2004-03-15
ISBN 10: 0824751094
ISBN 13: 9780824751098
Language: EN, FR, DE, ES & NL

Chirality in Drug Design and Development Book Review:

Covering every essential element in the development of chiral products, this reference provides a solid overview of the formulation, biopharmaceutical characteristics, and regulatory issues impacting the production of these pharmaceuticals. It supports researchers as they evaluate the pharmacodynamic, pharmacokinetic, and toxicological characteristics of specific enantiomers and chiral drug compounds and addresses in one convenient reference all the major challenges pertaining to drug chirality that have been neglected in the literature. Chirality in Drug Design and Development collects the latest studies from an interdisciplinary team of experts on chiral drug design.

On Chirality and the Universal Asymmetry

On Chirality and the Universal Asymmetry
Author: Georges H. Wagnière
Publsiher: John Wiley & Sons
Total Pages: 256
Release: 2008-09-26
ISBN 10: 3906390608
ISBN 13: 9783906390604
Language: EN, FR, DE, ES & NL

On Chirality and the Universal Asymmetry Book Review:

Until half a century ago, it was assumed that the forces of nature were symmetric and that they did not distinguish between right and left, between image and mirror image. The discovery of the violation of parity in 1956 was more than a sensation, for some it was a shock. It implied that the universe displays handedness, or chirality, and that it is fundamentally asymmetric. Remarkably, a most striking asymmetry is encountered in the realm of biology. Living organisms contain proteins built almost exclusively from L-amino acids, and nucleic acids derived from D-sugars only. Yet a mirror-image biochemistry, based on D-amino acids and L-sugars is, from a purely chemical standpoint, entirely conceivable. Where, then, does this extraordinary natural selectivity come from? Is it directly, or indirectly, connected to the universal violation of parity? This book is meant as a brief review of the various manifestations of handedness, or chirality, in the universe. It does not attempt to present a solution to basic questions which perhaps will never be unambiguously and conclusively answered. Rather, it is an excursion through nature, to observe and recognize how the chirality manifests itself at different structural levels. The excursion starts in the chemistry and physics laboratory. Then a journey into outer space and back in time is undertaken. After a return to our planet Earth, the focus is on the development of living organisms. The text should be accessible to anyone having the equivalent of a first-year university instruction in physics and chemistry. It is also hoped that a layperson with a more modest scientific formation may gain a general impression of the basic asymmetry in nature and of the fundamental significance of chirality. Mathematical expressions, wherever they occur, may then be overlooked. Some more difficult sections may be skipped. A Glossary preceding the Subject Index should be helpful.

The Origin of Chirality in the Molecules of Life

The Origin of Chirality in the Molecules of Life
Author: Albert Guijarro,Miguel Yus
Publsiher: Royal Society of Chemistry
Total Pages: 150
Release: 2008-01-01
ISBN 10: 0854041567
ISBN 13: 9780854041565
Language: EN, FR, DE, ES & NL

The Origin of Chirality in the Molecules of Life Book Review:

Few times an unsolved issue in science has dealt with a larger number of approaches or theories intending to shed light on it and few times this has been done from so different, often orthogonal perspectives. This book covers a hot topic, one of the unsolved problems not just in chemistry, but in science.

Chirality in Biological Nanospaces

Chirality in Biological Nanospaces
Author: Nilashis Nandi
Publsiher: CRC Press
Total Pages: 209
Release: 2011-07-27
ISBN 10: 1439840032
ISBN 13: 9781439840030
Language: EN, FR, DE, ES & NL

Chirality in Biological Nanospaces Book Review:

Chirality is widely studied and omnipresent in biological molecules. However, how the retention of enantiomeric forms persists in many life processes without racemization is still unclear, and the molecular understanding of the stringent chiral specificity in enzymatic reactions is sparse. An overview of the influence of chirality in driving reactions within enzymatic cavities, Chirality in Biological Nanospaces: Reactions in Active Sites covers: Influences of molecular chirality on the structure of the active site and network of interactions to drive reactions with improved speed, accuracy, and efficiency The conserved features of the organization of the active site structures of enzymes The intricate interplay of electrostatic, hydrophobic, and van der Waals interactions Interactions between the active site residues and the substrate molecules Despite being time-consuming and expensive, trial-and-error is often the primary method used to develop synthetic enzymes. This book describes methods that combine crystallographic studies with electronic structure-based computational analysis. These methods may lead to future elucidation of new drugs that can target biological active sites with better efficacy and can be used to design custom-made novel biocytes with improved efficiency.

Asymmetry in Biological Homochirality

Asymmetry in Biological Homochirality
Author: David Hochberg
Publsiher: MDPI
Total Pages: 102
Release: 2021-06-04
ISBN 10: 3036504427
ISBN 13: 9783036504421
Language: EN, FR, DE, ES & NL

Asymmetry in Biological Homochirality Book Review:

Chirality, or handedness, is a fundamental physical characteristic, which spans the length scales ranging from elementary particles to the chiral asymmetry of spiral galaxies. The way in which chirality in chemistry, or molecular handedness, may have emerged in a primitive terrestrial environment, and how it can be triggered, amplified, and transferred, are deeply challenging problems rooted in both fundamental scientific interests and the technological potentials for science and society. Chirality constitutes a unifying feature of the living world and is a prime driving force for molecular selection and genetic evolution in biology. In this book, we offer a selection of five distinct approaches to this problem by leading experts in the field. The selected topics range from protein chirality and its relevance to protein ageing, protein aggregation and neurodegeneration, entropy production associated with chiral symmetry breaking in closed systems, chiral oscillations in polymerization models involving higher-order oligomers, the mirror symmetry breaking in liquids and its implications for the development of homochirality in abiogenesis, the role of chirality in the chemical sciences, and some philosophical implications of chirality.

Chirality in Drug Design and Synthesis

Chirality in Drug Design and Synthesis
Author: C. Brown
Publsiher: Academic Press
Total Pages: 243
Release: 2013-10-22
ISBN 10: 1483288242
ISBN 13: 9781483288246
Language: EN, FR, DE, ES & NL

Chirality in Drug Design and Synthesis Book Review:

Chirality in Drug Design and Synthesis is a collection of papers that discusses the property of asymmetry in the structural and synthetic chemistry of natural products, including the significance of chirality in medicinal chemistry. These papers examine the need for the preparation and study of pure enantiomers of chiral drug substances and their mechanism of interaction with enzymes and receptors. These papers also investigate the techniques in studying these interactions, as well as analyze the methods for their synthesis in enantiomerically pure form. One paper discusses the pharmacological and pharmacokinetic analyses made that point to the differences in the activity and disposition of enantiometric pairs. Another paper reviews the implications of the neglect of stereoselectivity at the different levels during the examination process of racemic drugs. Since no general guidelines exists for the development of drugs with chiral centers, one paper suggests a case-by-case approach in evaluating the safety and efficacy of drugs, particularly as regards how isomers differ in their effects. This collection is suitable for the pharmacologist, medicinal chemists, toxicologists, mechanistic chemists and synthetic organic chemists.

Chiral Nanoprobes for Biological Applications

Chiral Nanoprobes for Biological Applications
Author: Chuanlai Xu
Publsiher: John Wiley & Sons
Total Pages: 304
Release: 2022-05-04
ISBN 10: 3527833595
ISBN 13: 9783527833597
Language: EN, FR, DE, ES & NL

Chiral Nanoprobes for Biological Applications Book Review:

A comprehensive overview exploring the biological applications of chiral nanomaterials Chirality has been the centerpiece of many multidisciplinary fields within the broader umbrella of the sciences. Recent advancements in nanoscience have spurred a growing interest in the dynamic field of chiral nanomaterials. In particular, the recent breakthroughs in chiral nanocrystals have presented an intriguing avenue whose potential application may address some key issues at the heart of nanosciences. While little attention has been focused on the biological implications of such advances, this arena is attracting theoretical and applicative interests. Seeking to provide a thorough introduction to the field as well as fill this gap in scholarship, Chiral Nanoprobes for Biological Applications first provides a comprehensive review of the state-of-the-art development of strong chiroptical nanomaterials, describing how a synthesis and self-assembly approach can enable one to design and create a number of functional chiral nanomaterials. From there, the authors discuss the biological applications of chiral nanomaterials, such as extracellular bioanalysis, intracellular bioanalysis, and chiral recognition, as well as photothermal and photodynamics therapy. In doing so, the book seeks emphasize the potential in multidisciplinary approaches to this up-and-coming field. Chiral Nanoprobes for Biological Applications readers will also find: A particular emphasis on milestones achieved for key chiral nanoprobes research from the last five years A discussion of future research directions A helpful guide for new researchers and established professionals alike Chiral Nanoprobes for Biological Applications is a useful reference for materials scientists, biochemists, protein chemists, stereo chemists, polymer chemists, and physical chemists. It is also a useful tool for libraries.

Fundamentals Of Supramolecular Chirality

Fundamentals Of Supramolecular Chirality
Author: Roberto Purrello,Alessandro D'urso
Publsiher: World Scientific
Total Pages: 224
Release: 2021-10-18
ISBN 10: 1800610262
ISBN 13: 9781800610262
Language: EN, FR, DE, ES & NL

Fundamentals Of Supramolecular Chirality Book Review:

Fundamentals of Supramolecular Chirality is a critical description of the start and advancement of supramolecular chirality. This book focuses on the noncovalent approach with some supplementary examples of covalent supramolecular chirality.This contribution to supramolecular chirality is not intended to be a mere catalogue and description of the work done. It also traces a philosophical path following the development and possible perspectives of this topic, providing not a review but a critical examination of the field.

Amplification of Chirality

Amplification of Chirality
Author: Kenso Soai
Publsiher: Springer Science & Business Media
Total Pages: 212
Release: 2008-07-11
ISBN 10: 3540778683
ISBN 13: 9783540778684
Language: EN, FR, DE, ES & NL

Amplification of Chirality Book Review:

Amplification of Chirality presents critical reviews of the present position and future trends in modern chemical research. The book contains short and concise reports on chemistry. Each is written by the world renowned experts. Still valid and useful after 5 or 10 years, more information as well as the electronic version of the whole content available at: springerlink.com.

Chirality and Biological Activity

Chirality and Biological Activity
Author: Hartmut Frank,Bo Holmstedt,Bernard Testa
Publsiher: Wiley-Liss
Total Pages: 312
Release: 1990
ISBN 10: 1928374650XXX
ISBN 13: UOM:39015015518411
Language: EN, FR, DE, ES & NL

Chirality and Biological Activity Book Review:

Reporting on the latest advances in molecular asymmetry, it explores the development of stereochemical analysis and its applications to the biosciences. Applications to pharmacology and therapeutics, food and beverage chemistry, the study of pesticides and other zenobiotics are also covered. Chapters examine the molecular principles of chiral recognition and biological selectivity and discuss stereoselectivity in drug action and metabolism. Some of the specific issues covered include: gas and liquid chromatography of enantiomers on chiral stationary phases; stereochemical assays of chiral drugs; pyrethroid isomers; configurational modification of peptide hormones; chiral fruit flavors; and human pharmacokinetics of enantiomers administered as racemates.