Antimalarial Agents

Antimalarial Agents
Author: Graham L. Patrick
Publsiher: Elsevier
Total Pages: 622
Release: 2020-05-30
ISBN 10: 0081012411
ISBN 13: 9780081012413
Language: EN, FR, DE, ES & NL

Antimalarial Agents Book Review:

Antimalarial Agents: Design and Mechanism of Action seeks to support medicinal chemists in their work towards antimalarial solution, providing practical guidance on current developments and highlighting promising leads for the future. Malaria is a deadly disease which threatens half of the world’s population. Advances over the last decade have seen vast improvements in the effectiveness of both preventative measures and treatments, but the rapid adaptability of the disease means that the ongoing search for improved and novel antimalarial drugs is essential. Beginning with a focus on biological aspects of malaria, this book highlights the lifecycle of the parasite responsible for malaria, the problem of resistance, genetic mapping of the parasite’s genome, established drug targets, and potential drug targets for the future. The book also includes detailed study of the medicinal chemistry of antimalarial agents and a focus on the design of antimalarial drugs. Drawing on the knowledge of its expert authors and coupling historic research with current findings to provide a full picture of both past and current milestones, Antimalarial Agents: Design and Mechanism of Action is a comprehensive yet accessible guide for all those involved in the design, development and administration of antimalarial drugs, including academic researchers, medicinal chemists, malaria researchers and pharmaceutical scientists. Consolidates both past and current developments in the discovery and design of antimalarial drugs Presents content in a style that is both thorough and engaging, providing a supportive and guiding reference to students and researchers from interdisciplinary backgrounds Highlights drug targets currently considered to be the most promising for future therapies, and the classes of compounds that are currently being studied and perfected

Hepatotoxicity

Hepatotoxicity
Author: Hyman J. Zimmerman
Publsiher: Lippincott Williams & Wilkins
Total Pages: 848
Release: 1999
ISBN 10: 9780781719520
ISBN 13: 0781719526
Language: EN, FR, DE, ES & NL

Hepatotoxicity Book Review:

Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

Saving Lives Buying Time

Saving Lives  Buying Time
Author: Institute of Medicine,Board on Global Health,Committee on the Economics of Antimalarial Drugs
Publsiher: National Academies Press
Total Pages: 384
Release: 2004-10-09
ISBN 10: 0309092183
ISBN 13: 9780309092180
Language: EN, FR, DE, ES & NL

Saving Lives Buying Time Book Review:

For more than 50 years, low-cost antimalarial drugs silently saved millions of lives and cured billions of debilitating infections. Today, however, these drugs no longer work against the deadliest form of malaria that exists throughout the world. Malaria deaths in sub-Saharan Africaâ€"currently just over one million per yearâ€"are rising because of increased resistance to the old, inexpensive drugs. Although effective new drugs called “artemisinins†are available, they are unaffordable for the majority of the affected population, even at a cost of one dollar per course. Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance examines the history of malaria treatments, provides an overview of the current drug crisis, and offers recommendations on maximizing access to and effectiveness of antimalarial drugs. The book finds that most people in endemic countries will not have access to currently effective combination treatments, which should include an artemisinin, without financing from the global community. Without funding for effective treatment, malaria mortality could double over the next 10 to 20 years and transmission will intensify.

Assessment of Long Term Health Effects of Antimalarial Drugs When Used for Prophylaxis

Assessment of Long Term Health Effects of Antimalarial Drugs When Used for Prophylaxis
Author: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice
Publsiher: National Academies Press
Total Pages: 426
Release: 2020-03-24
ISBN 10: 0309672139
ISBN 13: 9780309672139
Language: EN, FR, DE, ES & NL

Assessment of Long Term Health Effects of Antimalarial Drugs When Used for Prophylaxis Book Review:

Among the many who serve in the United States Armed Forces and who are deployed to distant locations around the world, myriad health threats are encountered. In addition to those associated with the disruption of their home life and potential for combat, they may face distinctive disease threats that are specific to the locations to which they are deployed. U.S. forces have been deployed many times over the years to areas in which malaria is endemic, including in parts of Afghanistan and Iraq. Department of Defense (DoD) policy requires that antimalarial drugs be issued and regimens adhered to for deployments to malaria-endemic areas. Policies directing which should be used as first and as second-line agents have evolved over time based on new data regarding adverse events or precautions for specific underlying health conditions, areas of deployment, and other operational factors At the request of the Veterans Administration, Assessment of Long-Term Health Effects of Antimalarial Drugs When Used for Prophylaxis assesses the scientific evidence regarding the potential for long-term health effects resulting from the use of antimalarial drugs that were approved by FDA or used by U.S. service members for malaria prophylaxis, with a focus on mefloquine, tafenoquine, and other antimalarial drugs that have been used by DoD in the past 25 years. This report offers conclusions based on available evidence regarding associations of persistent or latent adverse events.

CDC Yellow Book 2018 Health Information for International Travel

CDC Yellow Book 2018  Health Information for International Travel
Author: Centers for Disease Control and Prevention CDC
Publsiher: Oxford University Press
Total Pages: 672
Release: 2017-04-17
ISBN 10: 0190628634
ISBN 13: 9780190628635
Language: EN, FR, DE, ES & NL

CDC Yellow Book 2018 Health Information for International Travel Book Review:

THE ESSENTIAL WORK IN TRAVEL MEDICINE -- NOW COMPLETELY UPDATED FOR 2018 As unprecedented numbers of travelers cross international borders each day, the need for up-to-date, practical information about the health challenges posed by travel has never been greater. For both international travelers and the health professionals who care for them, the CDC Yellow Book 2018: Health Information for International Travel is the definitive guide to staying safe and healthy anywhere in the world. The fully revised and updated 2018 edition codifies the U.S. government's most current health guidelines and information for international travelers, including pretravel vaccine recommendations, destination-specific health advice, and easy-to-reference maps, tables, and charts. The 2018 Yellow Book also addresses the needs of specific types of travelers, with dedicated sections on: · Precautions for pregnant travelers, immunocompromised travelers, and travelers with disabilities · Special considerations for newly arrived adoptees, immigrants, and refugees · Practical tips for last-minute or resource-limited travelers · Advice for air crews, humanitarian workers, missionaries, and others who provide care and support overseas Authored by a team of the world's most esteemed travel medicine experts, the Yellow Book is an essential resource for travelers -- and the clinicians overseeing their care -- at home and abroad.

Antimalarial Drugs

Antimalarial Drugs
Author: Qigui Li,Peter J. Weina
Publsiher: Nova Science Pub Incorporated
Total Pages: 657
Release: 2013-01-01
ISBN 10: 9781629480138
ISBN 13: 1629480134
Language: EN, FR, DE, ES & NL

Antimalarial Drugs Book Review:

Anti-malarial drugs are medicines that prevent or treat malaria, a disease which takes a great toll on human health and well-being, particularly in tropical regions including Africa south of the Sahara, South and Southeast Asia, Oceania, and parts of the Americas. In recent years, strains of Plasmodium have become increasingly resistant to more anti-malarial drugs and researchers have stepped up efforts to revise anti-malarial drug policies and develop new anti-malarial strategies. Resistance has arisen to all classes of antimalarials (chloroquine, amodiaquine, mefloquine and sulfadoxine-pyrimethamine) except, as yet, definitively to the artemisinin derivatives. In order to prevent widespread resistance, the concept of anti-malarial combination therapy (CT) has been employed and a global resistance surveillance system (World Anti-malarial Resistance Networks) has been established. This book explores the use of these drugs in current health care.

Antimalarial Chemotherapy

Antimalarial Chemotherapy
Author: Philip J. Rosenthal
Publsiher: Springer Science & Business Media
Total Pages: 396
Release: 2001-04-01
ISBN 10: 1592591116
ISBN 13: 9781592591114
Language: EN, FR, DE, ES & NL

Antimalarial Chemotherapy Book Review:

Philip Rosenthal, MD, and a panel of leading malaria experts drawn from academia, the military, and international health organizations survey the latest scientific understanding of antimalarial chemotherapy, emphasizing the molecular mechanisms of resistance and the description of important new targets. Their survey covers the current status of malarial and antimalarial chemotherapy, the relevant biology and biochemistry of malaria parasites, the antimalarial drugs currently available, new chemical approaches to chemotherapy, and possible new targets for chemotherapy. Comprehensive and cutting-edge, Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery clearly delineates all the basic and clinical research now addressing one of the world's major unresolved disease problems, work that is now powerfully driving the rapid pace of antimalarial drug discovery today.

Antimalarial Agents

Antimalarial Agents
Author: Poul Thompson
Publsiher: Elsevier
Total Pages: 408
Release: 2012-12-02
ISBN 10: 032315168X
ISBN 13: 9780323151689
Language: EN, FR, DE, ES & NL

Antimalarial Agents Book Review:

Medicinal Chemistry, Volume 12: Antimalarial Agents: Chemistry and Pharmacology presents the essentials of both biology and chemistry pertinent to the chemotherapy of malaria. This book discusses the nature of the disease, the physiology and biochemistry of the plasmodia, and the mode of action of drugs. Organized into 19 chapters, this volume begins with an overview of the most intensive efforts to develop synthetic antimalarial drugs. This text then examines how drugs are evaluated as well as the specific chemotherapy in malaria. Other chapters consider the diversity of chemical structures exhibiting antimalarial activity with emphasis on structure–activity relationships and methods of synthesis. This book discusses as well the plasmodial effects by quinine in vivo. The final chapter deals with the miscellaneous structures known to have activity against some types of plasmodial infection in animals. This book is a valuable resource for chemists and biologists involved in the development of antimalarial drugs.

From Artemisia Annua L to Artemisinins Hindi Edition

From Artemisia Annua L  to Artemisinins  Hindi Edition
Author: Youyou Tu
Publsiher: Unknown
Total Pages: 456
Release: 2021-10-31
ISBN 10: 9781487804459
ISBN 13: 1487804458
Language: EN, FR, DE, ES & NL

From Artemisia Annua L to Artemisinins Hindi Edition Book Review:

From Artemisia annua L. to Artemisinins: The Discovery and Development of Artemisinins and Antimalarial Agents is the first book that systematically introduces the origin and development of artemisinine and artemisinine-based drugs. It includes four distinct sections, including Artemisia annua L., Artemisinin, Dihydroartemisinin, and other artemisinin derivatives. Tu Youyou, the chief inventor of artemisinin, together with other members from the research team, have written a book that will be a valuable reference work for both researchers involved in the medical industry and scholars who are interested in undertaking innovative research.

Current Topics in Malaria

Current Topics in Malaria
Author: Alfonso J. Rodriguez-Morales
Publsiher: Unknown
Total Pages: 506
Release: 2016-11-30
ISBN 10: 9535127896
ISBN 13: 9789535127895
Language: EN, FR, DE, ES & NL

Current Topics in Malaria Book Review:

Malaria

Malaria
Author: Institute of Medicine,Division of International Health,Committee for the Study on Malaria Prevention and Control
Publsiher: National Academies Press
Total Pages: 328
Release: 1991-02-01
ISBN 10: 9780309045278
ISBN 13: 0309045274
Language: EN, FR, DE, ES & NL

Malaria Book Review:

Malaria is making a dramatic comeback in the world. The disease is the foremost health challenge in Africa south of the Sahara, and people traveling to malarious areas are at increased risk of malaria-related sickness and death. This book examines the prospects for bringing malaria under control, with specific recommendations for U.S. policy, directions for research and program funding, and appropriate roles for federal and international agencies and the medical and public health communities. The volume reports on the current status of malaria research, prevention, and control efforts worldwide. The authors present study results and commentary on the: Nature, clinical manifestations, diagnosis, and epidemiology of malaria. Biology of the malaria parasite and its vector. Prospects for developing malaria vaccines and improved treatments. Economic, social, and behavioral factors in malaria control.

Antimalarial Natural Products

Antimalarial Natural Products
Author: A. Douglas Kinghorn,Heinz Falk,Simon Gibbons,Yoshinori Asakawa,Ji-Kai Liu,Verena M. Dirsch
Publsiher: Springer
Total Pages: 106
Release: 2022-01-04
ISBN 10: 9783030898724
ISBN 13: 3030898725
Language: EN, FR, DE, ES & NL

Antimalarial Natural Products Book Review:

This volume begins with a short history of malaria and follows with a summary of its biology. It then traces the fascinating history of the discovery of quinine for malaria treatment, and then describes quinine’s biosynthesis, its mechanism of action, and its clinical use, concluding with a discussion of synthetic antimalarial agents based on quinine’s structure. It also covers the discovery of artemisinin and its development as the source of the most effective current antimalarial drug, including summaries of its synthesis and biosynthesis, its mechanism of action, and its clinical use and resistance. A short discussion of other clinically used antimalarial natural products leads to a detailed treatment of additional natural products with significant antiplasmodial activity, classified by compound type. Although the search for new antimalarial natural products from Nature’s combinatorial library is challenging, it is very likely to yield new antimalarial drugs. This book thus ends by identifying ten natural products with development potential as clinical antimalarial agents.

Neglected Diseases and Drug Discovery

Neglected Diseases and Drug Discovery
Author: Michael J Palmer,Timothy N.C. Wells
Publsiher: Royal Society of Chemistry
Total Pages: 458
Release: 2011-10-28
ISBN 10: 184973349X
ISBN 13: 9781849733496
Language: EN, FR, DE, ES & NL

Neglected Diseases and Drug Discovery Book Review:

There are about 8 million deaths each year from neglected tropical diseases (NTDs) in the underdeveloped world, whilst drug discovery focus and practice is only recently taking on greater urgency and embracing the latest technologies. This unique book is a state of the art review of drug discovery in respect of NTDs and highlights best practice to guide the ongoing drug discovery effort and also to raise debate and awareness in areas that remain highly neglected. All the major diseases such as malaria, trypanosomatids and TB are covered, with a review of each disease and established compounds, new mechanistic classes and new horizons. Each chapter highlights the key science that has led to breakthroughs, with detailed assessment of the key medicinal chemistry involved, and critical appraisal of new emerging approaches. Later chapters highlight under publicized disease areas where the medical needs are neglected and research is very limited, to raise awareness. The editors, acknowledged experts in the field, have a wealth of experience in successful drug discovery practice and tropical diseases.

Advances in Malaria Research

Advances in Malaria Research
Author: Deepak Gaur,Virander S. Chauhan,Chetan E. Chitnis
Publsiher: John Wiley & Sons
Total Pages: 600
Release: 2016-12-27
ISBN 10: 1118493796
ISBN 13: 9781118493793
Language: EN, FR, DE, ES & NL

Advances in Malaria Research Book Review:

Thoroughly reviews our current understanding of malarial biology Explores the subject with insights from post-genomic technologies Looks broadly at the disease, vectors of infection, and treatment and prevention strategies A timely publication with chapters written by global researchers leaders

Lahita s Systemic Lupus Erythematosus

Lahita s Systemic Lupus Erythematosus
Author: Robert G. Lahita
Publsiher: Academic Press
Total Pages: 730
Release: 2021-07-23
ISBN 10: 0323914888
ISBN 13: 9780323914888
Language: EN, FR, DE, ES & NL

Lahita s Systemic Lupus Erythematosus Book Review:

Systemic lupus erythematosus (SLE), commonly called lupus, is a chronic autoimmune disorder that can affect virtually any organ of the body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness or remission. Because its symptoms come and go and mimic those of other diseases, lupus is difficult to diagnose. There is no single laboratory test that can definitively prove that a person has the complex illness. To date, lupus has no known cause or cure. Early detection and treatment are the key to a better health outcome and can usually lessen the progression and severity of the disease. Anti-inflammatory drugs, antimalarials, and steroids (such as cortisone and others) are often used to treat lupus. Cytotoxic chemotherapies, like those used in the treatment of cancer, are also used to suppress the immune system in lupus patients. A new edition of this established and well-regarded reference combines basic science with clinical science to provide a translational medicine model. Systemic Lupus Erythematosus, Sixth Edition, is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease, and a reference work for hospital libraries. Completely updated, revised, and expanded with the most comprehensive and accessible reference on SLE for clinicians and scientists Full-color presentation throughout the book Provides the latest information available on diagnosis and treatment Incorporates an international panel of authors who are experts in their fields, with an emphasis on young, cutting-edge scientists and physicians

Guidelines for the Treatment of Malaria Third Edition

Guidelines for the Treatment of Malaria  Third Edition
Author: World Health Organization
Publsiher: World Health Organization
Total Pages: 313
Release: 2015-08-13
ISBN 10: 9241549122
ISBN 13: 9789241549127
Language: EN, FR, DE, ES & NL

Guidelines for the Treatment of Malaria Third Edition Book Review:

Malaria remains an important cause of illness and death in children and adults in countries in which it is endemic. Malaria control requires an integrated approach including prevention (primarily vector control) and prompt treatment with effective antimalarial agents. Malaria case management consisting of prompt diagnosis and effective treatment remains a vital component of malaria control and elimination strategies. Since the publication of the first edition of the Guidelines for the treatment of malaria in 2006 and the second edition in 2010 all countries in which P. falciparum malaria is endemic have progressively updated their treatment policy from use of ineffective monotherapy to the currently recommended artemisinin-based combination therapies (ACT). This has contributed substantially to current reductions in global morbidity and mortality from malaria. Unfortunately resistance to artemisinins has arisen recently in P. falciparum in South-East Asia which threatens these gains. This third edition of the WHO Guidelines for the treatment of malaria contains updated recommendations based on a firmer evidence base for most antimalarial drugs and in addition include recommendation on the use of drugs to prevent malaria in groups at high risk. The Guidelines provide a framework for designing specific detailed national treatment protocols taking into account local patterns of resistance to antimalarial drugs and health service capacity. It provides recommendations on treatment of uncomplicated and severe malaria in all age groups all endemic areas in special populations and several complex situations. In addition on the use of antimalarial drugs as preventive therapy in healthy people living in malaria-endemic areas who are high risk in order to reduce morbidity and mortality from malaria. The Guidelines are designed primarily for policy-makers in ministries of health who formulate country-specific treatment guidelines. Other groups that may find them useful include health professionals and public health and policy specialists that are partners in health or malaria control and the pharmaceutical industry. The treatment recommendations in the main document are brief; for those who wish to study the evidence base in more detail a series of annexes is provided with references to the appropriate sections of the main document.

Malaria Drugs Disease and Post genomic Biology

Malaria  Drugs  Disease and Post genomic Biology
Author: David Sullivan,Sanjeev Krishna
Publsiher: Springer Science & Business Media
Total Pages: 340
Release: 2006-01-14
ISBN 10: 3540290885
ISBN 13: 9783540290889
Language: EN, FR, DE, ES & NL

Malaria Drugs Disease and Post genomic Biology Book Review:

Despite rapid increases in knowledge, malaria continues to kill more than a million people each year and causes symptomatic disease in a further 300 million individuals. This volume brings some of the world's best investigators to describe recent advances in both the scientific and clinical aspects of malaria, and bridges between the two.

Machine Learning in Chemistry

Machine Learning in Chemistry
Author: Hugh M Cartwright
Publsiher: Royal Society of Chemistry
Total Pages: 546
Release: 2020-07-15
ISBN 10: 1839160241
ISBN 13: 9781839160240
Language: EN, FR, DE, ES & NL

Machine Learning in Chemistry Book Review:

Progress in the application of machine learning (ML) to the physical and life sciences has been rapid. A decade ago, the method was mainly of interest to those in computer science departments, but more recently ML tools have been developed that show significant potential across wide areas of science. There is a growing consensus that ML software, and related areas of artificial intelligence, may, in due course, become as fundamental to scientific research as computers themselves. Yet a perception remains that ML is obscure or esoteric, that only computer scientists can really understand it, and that few meaningful applications in scientific research exist. This book challenges that view. With contributions from leading research groups, it presents in-depth examples to illustrate how ML can be applied to real chemical problems. Through these examples, the reader can both gain a feel for what ML can and cannot (so far) achieve, and also identify characteristics that might make a problem in physical science amenable to a ML approach. This text is a valuable resource for scientists who are intrigued by the power of machine learning and want to learn more about how it can be applied in their own field.

Treatment and Prevention of Malaria

Treatment and Prevention of Malaria
Author: Henry M. Staines,Sanjeev Krishna
Publsiher: Springer Science & Business Media
Total Pages: 318
Release: 2012-01-06
ISBN 10: 3034604793
ISBN 13: 9783034604796
Language: EN, FR, DE, ES & NL

Treatment and Prevention of Malaria Book Review:

Malaria has defeated previous efforts at eradication and remains a massive global public health problem despite being readily preventable and treatable. It is a devastating disease that also extracts huge economic costs from the poorest countries in endemic regions. Starting with an overview of the disease and its current political, financial and technical context, this Milestones in Drug Therapy volume describes the history, chemistry, mechanisms of action and resistance, preclinical and clinical use, pharmacokinetics and safety and tolerability of the current range of antimalarial drugs. There is particular emphasis on artemisinins and related peroxides, as these drugs have now become the frontline treatment for malaria. Next generation antimalarials, molecular markers for detecting resistance, the importance of diagnostics and disease prevention are also covered in detail.

CDC Yellow Book 2020

CDC Yellow Book 2020
Author: CENTERS FOR DISEASE CONTROL AND PREVENTION. (CDC)
Publsiher: Oxford University Press, USA
Total Pages: 720
Release: 2019-06-11
ISBN 10: 0190065974
ISBN 13: 9780190065973
Language: EN, FR, DE, ES & NL

CDC Yellow Book 2020 Book Review:

The definitive reference for travel medicine, updated for 2020! "A beloved travel must-have for the intrepid wanderer." -Publishers Weekly "A truly excellent and comprehensive resource." -Journal of Hospital Infection The CDC Yellow Book offers everything travelers and healthcare providers need to know for safe and healthy travel abroad. This 2020 edition includes: · Country-specific risk guidelines for yellow fever and malaria, including expert recommendations and 26 detailed, country-level maps · Detailed maps showing distribution of travel-related illnesses, including dengue, Japanese encephalitis, meningococcal meningitis, and schistosomiasis · Guidelines for self-treating common travel conditions, including altitude illness, jet lag, motion sickness, and travelers' diarrhea · Expert guidance on food and drink precautions to avoid illness, plus water-disinfection techniques for travel to remote destinations · Specialized guidelines for non-leisure travelers, study abroad, work-related travel, and travel to mass gatherings · Advice on medical tourism, complementary and integrative health approaches, and counterfeit drugs · Updated guidance for pre-travel consultations · Advice for obtaining healthcare abroad, including guidance on different types of travel insurance · Health insights around 15 popular tourist destinations and itineraries · Recommendations for traveling with infants and children · Advising travelers with specific needs, including those with chronic medical conditions or weakened immune systems, health care workers, humanitarian aid workers, long-term travelers and expatriates, and last-minute travelers · Considerations for newly arrived adoptees, immigrants, and refugees Long the most trusted book of its kind, the CDC Yellow Book is an essential resource in an ever-changing field -- and an ever-changing world.