Antifungal Compounds Discovery

Antifungal Compounds Discovery
Author: Marina Sokovic,Konstantinos Liaras
Publsiher: Elsevier
Total Pages: 290
Release: 2020-09-18
ISBN 10: 0128158255
ISBN 13: 9780128158258
Language: EN, FR, DE, ES & NL

Antifungal Compounds Discovery Book Review:

Fungi are both the cause of many major health problems and an incredible source of compounds for developing new medicinal treatments, and with the increasing emergence of multidrug resistance, the need for new antimicrobial agents is greater than ever. Antifungal Compounds Discovery provides researchers with a detailed study of both natural and synthetic compounds that can be effective against a variety of fungal species, supporting and encouraging the design of innovative, potent new drug candidates for the treatment of fungal infections. Beginning with an introduction to both the history and latest developments in this field, the book goes on to provide helpful background information on key fungal species before outlining current antifungal therapies and reasons further development is needed. Detailed chapters then follow reviewing a broad range of natural and synthetic antifungal agents, and discussing the synergistic effect of working with both simultaneously. Finally, the book concludes by considering potential future developments in this important field. Supported with detailed schemes and key information on the biological activity of all selected compounds, Antifungal Compounds Discovery is a comprehensive guide helping researchers understand the relationship between specific chemical structures and their antifungal potency, and a key tool for all those involved in the identification and development of antimicrobial compounds. Provides an overview of the most specific mycotic infections and fungal species as background for compound development Presents the chemical formulas of all natural and synthetic compounds reviewed Combines detailed information about origin, isolation and possible therapeutic uses of all indexed compounds, including biological activity, mechanism of action and SAR information

Antifungal Compounds Discovery development and uses

Antifungal Compounds  Discovery  development  and uses
Author: Malcolm R. Siegel,Hugh Delane Sisler
Publsiher: Unknown
Total Pages: 1274
Release: 1977-01-01
ISBN 10: 9780824765576
ISBN 13: 0824765575
Language: EN, FR, DE, ES & NL

Antifungal Compounds Discovery development and uses Book Review:

V. 1- Discovery, developments, and uses; v. 2 - Interactions in biological and ecological systems.

Anticandidal Agents

Anticandidal Agents
Author: Awanish Kumar
Publsiher: Academic Press
Total Pages: 94
Release: 2016-09-12
ISBN 10: 012811312X
ISBN 13: 9780128113127
Language: EN, FR, DE, ES & NL

Anticandidal Agents Book Review:

Anticandidal Agents provides the latest information on candida drug resistance and its remedial implications. In this compilation, users will find a comprehensive view on overcoming resistance in anticandidal drugs, along with information on novel molecules. Candida albicans is an opportunistic pathogenic fungus responsible for life threating invasive and nosocomial infections across the globe. Candidiasis is a major cause of morbidity among immunocompromised patients. Infections caused by non-albicans candida like C. glabrata, C. parapsilosis, and C. tropicalis have also imposed a serious threat in the last few decades. Current treatment of candidiasis relies primarily on antifungal agents broadly categorized as azoles, polyenes, echinocandins, allylamines, and pyrimidines. Lately, antifungal resistance has emerged to be an obstruction of current treatment regime. A number of reasons are described in detail. Understanding the mechanisms of resistance is crucial for developing strategies for overcoming the hindrance in current therapeutics. Presents a complete understanding of candida resistance to help in the development of therapeutic expansion and novel drugs Provides thorough information on candida drug resistance and its remedial implications Covers crucial mechanisms of resistance that will help develop strategies for overcoming the hindrance in current therapeutics

Combating Fungal Infections

Combating Fungal Infections
Author: Iqbal Ahmad,Mohammad Owais,Mohammed Shahid,Farrukh Aqil
Publsiher: Springer Science & Business Media
Total Pages: 539
Release: 2010-08-03
ISBN 10: 364212173X
ISBN 13: 9783642121739
Language: EN, FR, DE, ES & NL

Combating Fungal Infections Book Review:

Fungi are eukaryotic microorganisms that are closely related to humans at cellular level. Human fungal pathogens belong to various classes of fungi, mainly zygo- cetes, ascomycetes, basidiomycetes, and deuteromycetes. In recent years, fungal infections have dramatically increased as a result of improved diagnosis, high frequency of catheterization, instrumentation, etc. However, the main cause remains the increasing number of immunosuppressed patients, mostly because of HIV infection and indiscriminate usage of antineoplastic and immunosuppressive agents, broad-spectrum antibiotics and prosthetic devices, and grafts in clinical settings. Presently available means of combating fungal infections are still weak and clumsy compared to control of bacterial infection. The present scenario of antifungal therapy is still based on two classes of antifungal drugs (polyenes and azoles). These drugs are effective in many cases, but display toxicity and limited spectrum of ef?cacy. The recent trend towards emergence of drug-resistant isolates in the clinic is an additional problem. In recent years, a few new antifungal drugs have entered the clinics, but they are expected to undergo same fate as the older antifungal drugs. The application of fungal genomics offers an unparalleled opportunity to develop novel antifungal drugs. However, it is too early to expect any novel drugs, as the antifungal drug discovery program is in the stage of infancy. Interestingly, several novel antifungal drug targets have been identi?ed and validated.

Antifungal Therapy

Antifungal Therapy
Author: Mahmoud A. Ghannoum, PhD, EMBA,Mahmoud A. Ghannoum,John R. Perfect,John R. Perfect, MD
Publsiher: CRC Press
Total Pages: 488
Release: 2016-04-19
ISBN 10: 0849387868
ISBN 13: 9780849387869
Language: EN, FR, DE, ES & NL

Antifungal Therapy Book Review:

A concise one-stop-practical reference for the various physicians dealing with fungal infections, Antifungal Therapy appeals to infectious disease physicians, transplant surgeons, dermatologists, and intensivists, as well as basic scientists and pharmaceutical company researchers interested in the state of antifungal therapy. This book provides a comprehensive, up-to-date overview of the pertinent issues pertaining to antifungal treatment. Divided into four interrelated sections for a cohesive discussion covers: history of antifungals from the discovery of the polyenes to the echinocandins antifungal susceptibility methods patient management animal models in drug development therapeutic strategies pharmacokinetic and pharmacogenomics trends in resistance

Antifungal Drug Discovery New Theories and New Therapies

Antifungal Drug Discovery  New Theories and New Therapies
Author: Chaminda Jayampath Seneviratne,Edvaldo Antonio Ribeiro Rosa
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2016-09-13
ISBN 10: 2889199509
ISBN 13: 9782889199501
Language: EN, FR, DE, ES & NL

Antifungal Drug Discovery New Theories and New Therapies Book Review:

Fungal infections such as candidoses can range from superficial mucous membrane infection to life-threatening systemic mycoses. Candida infections are a significant clinical problem globally due to rapid rise in compromised host populations including HIV/AIDS, organ transplant recipients and patients on chemotherapy. In addition, sharp increase in aging populations which are susceptible to fungal infections is expected in next few decades. Antifungal drugs are relatively difficult to develop compared to the antibacterial drugs owing to the eukaryotic nature of the cells. Therefore, only a handful of antifungal agents are currently available to treat the myriad of fungal infections. Moreover, rising antifungal resistance and host-related adverse reactions have limited the antifungal arsenal against fungal pathogens. In this research topic, we tried to update the theoretical aspects pertaining to the antifungal drug discovery i.e. proposed novel mechanisms, new drug targets and pathways. In addition, invited authors explored the new antifungal drugs derived from natural and synthetic sources which are currently under development. Contributors were encouraged to bring new insight into the antifungal drug discovery. We hope the reader may arrive at a general consensus on the possible strategies to combat ever increasing ubiquitous fungal infection in this new century.

Antimicrobial Drug Discovery

Antimicrobial Drug Discovery
Author: George Tegos,Eleftherios Mylonakis
Publsiher: CABI
Total Pages: 357
Release: 2012
ISBN 10: 1845939433
ISBN 13: 9781845939434
Language: EN, FR, DE, ES & NL

Antimicrobial Drug Discovery Book Review:

Resistance is on the rise among a variety of human pathogenic microorganisms associated with common and potentially life-threatening infections, including penicillin-resistant Streptococcus pneumonia and Methicillin-resistant Staphylococcus aureus (MRSA). There is increasing demand to approach the threat of multidrug resistance incorporating novel multidisciplinary methodologies and technological platforms. This book documents the latest research, covering current and promising activities in four key areas: computational chemistry and chemoinformatics, High Throughput Screening (HTS), non-vertebrate model hosts and light and nano-based technologies. It is essential reading for researchers and students in microbiology, biotechnology, pharmacology, chemistry and biology as well as medical professionals.

Anti fungal Drug Discovery

Anti fungal Drug Discovery
Author: Bradley Mark Tebbets
Publsiher: Unknown
Total Pages: 208
Release: 2012
ISBN 10: 1928374650XXX
ISBN 13: OCLC:822841247
Language: EN, FR, DE, ES & NL

Anti fungal Drug Discovery Book Review:

Antifungal Agents

Antifungal Agents
Author: G. K. Dixon,Leonard G. Copping,Derek W. Hollomon
Publsiher: Bios Scientific Pub Limited
Total Pages: 330
Release: 1995
ISBN 10: 1928374650XXX
ISBN 13: UCSC:32106012733215
Language: EN, FR, DE, ES & NL

Antifungal Agents Book Review:

Explores how new molecular technologies are interfacing with chemistry and biology in the search for new fungicide targets.

Advances in Antifungal Development

Advances in Antifungal Development
Author: Luisa W. Cheng,Jong Heon Kim,Kirkwood Land
Publsiher: Mdpi AG
Total Pages: 0
Release: 2022-07-20
ISBN 10: 9783036547688
ISBN 13: 3036547681
Language: EN, FR, DE, ES & NL

Advances in Antifungal Development Book Review:

This reprint describes recent advances made in the field of antifungal development, especially the discovery of new drugs and drug repurposing. The articles presented in this book provide useful information and insight for the development of new antifungal drugs or intervention strategies. The identification of new, safe molecules, and cellular targets, as well as the elucidation of their antifungal mechanisms of action, will further the effective control of fungal pathogens, especially those resistant to current therapeutic agents.

Discovery Identification and Evaluation of Antifungal Compounds Produced by Pseudomonas Syringae

Discovery  Identification  and Evaluation of Antifungal Compounds Produced by Pseudomonas Syringae
Author: Kevin N. Sorensen
Publsiher: Unknown
Total Pages: 238
Release: 1997
ISBN 10: 1928374650XXX
ISBN 13: OCLC:43961652
Language: EN, FR, DE, ES & NL

Discovery Identification and Evaluation of Antifungal Compounds Produced by Pseudomonas Syringae Book Review:

Burger s Medicinal Chemistry and Drug Discovery Therapeutic Agents

Burger s Medicinal Chemistry and Drug Discovery  Therapeutic Agents
Author: Manfred E. Wolff
Publsiher: Wiley-Interscience
Total Pages: 688
Release: 1996-04-26
ISBN 10: 9780471575573
ISBN 13: 0471575577
Language: EN, FR, DE, ES & NL

Burger s Medicinal Chemistry and Drug Discovery Therapeutic Agents Book Review:

The most comprehensive source of the latest information in drug discovery and medicinal chemistry BURGER'S MEDICINAL CHEMISTRY AND DRUG DISCOVERY, FIFTH EDITION, Volume 2: Therapeutic Agents Renowned for its incisive, systematic examination of the new classes of drugs, Burger's Medicinal Chemistry and Drug Discovery provides professionals with thorough, yet selective access to drug chemistry information in a convenient format. Volume 2 outlines the newest generation of drugs with the potential for controlling cardiovascular, gastrointestinal, and tubercular disease. These include: * Cholinergics and anticholinergics * Gastric proton pump inhibitors * Cardiac drugs and antihypertensive agents * Diuretic and urcosuric agents * Aminoglycoside, macrolide, glycopeptide, and other antibacterial antibiotics * Antimycobacterial and antifungal agents The behavior of each drug class is explored in terms of pathophysiology of the disease state, molecular mechanism of action, pharmacokinetics, toxicity, drug metabolism, and structure activity relationships. Special attention is given to fertile areas of further research. Burger's Medicinal Chemistry and Drug Discovery, Volume 2 is an essential reference for medical professionals and researchers working today. Burger's Medicinal Chemistry, Fifth Edition consists of five volumes: Volume 1: Principles and Practice (0-471-57556-9) 1995 " . . . an essential addition to the libraries of any medicinal chemist . . . an outstanding work . . . highly praised as a fountain of information in drug studies and research."--Journal of Medicinal Chemistry * Volume 2: Therapeutic Agents (0-471-57557-7) 1996 * Volume 3: Therapeutic Agents (0-471-57558-5) 1996 * Volume 4: Therapeutic Agents (0-471-57559-3) 1997 * Volume 5: Therapeutic Agents (0-471-57560-7) 1997

Biologically Active Natural Products

Biologically Active Natural Products
Author: Stephen J. Cutler,Horace G. Cutler
Publsiher: CRC Press
Total Pages: 296
Release: 1999-07-27
ISBN 10: 1420048651
ISBN 13: 9781420048650
Language: EN, FR, DE, ES & NL

Biologically Active Natural Products Book Review:

Biologically Active Natural Products: Pharmaceuticals demonstrates the connections between agrochemicals and pharmaceuticals and explores the use of plants and plant products in the formulation and development of pharmaceuticals. Experts from around the world examine a multitude of topics, including evaluation of extracts from tropical plants for p

Discovery of Novel Natural Products with Therapeutic Potential

Discovery of Novel Natural Products with Therapeutic Potential
Author: Vincent P. Gullo
Publsiher: Newnes
Total Pages: 544
Release: 2013-10-22
ISBN 10: 1483292134
ISBN 13: 9781483292137
Language: EN, FR, DE, ES & NL

Discovery of Novel Natural Products with Therapeutic Potential Book Review:

Although science has discovered effective drugs for many of the diseases that afflict mankind, many human health problems remain untreatable. The search for novel therapeutic agents is always ongoing. This book will describe some of the diverse sources of natural products, such as terrestrial and marine environments; and will review how research has increased knowledge of biological systems and human disease, leading to the design of targeted asssays, amenable to high volume screening.

New Approaches for Antifungal Drugs

New Approaches for Antifungal Drugs
Author: FERNANDES,PRABHAVATHI
Publsiher: Birkhäuser
Total Pages: 201
Release: 1992-08-01
ISBN 10: 9780817636029
ISBN 13: 0817636021
Language: EN, FR, DE, ES & NL

New Approaches for Antifungal Drugs Book Review:

Reviews research on the chemotherapy of fungal diseases, which has progressed at a much slower rate than that against bacterial diseases. Emphasizes the search during the past decade for selective targets of therapeutic agents, selection being the main difficulty because of the eukaryotic nature of fungi. In addition to several novel drugs, considers structures, processes, and proteins as potential targets; and new approaches such as antifungal agents from plants, and genetic methods of drug discovery. Annotation copyrighted by Book News, Inc., Portland, OR

The Fungal Cell Wall

The Fungal Cell Wall
Author: Jean-Paul Latgé
Publsiher: Springer Nature
Total Pages: 369
Release: 2020-08-12
ISBN 10: 3030499286
ISBN 13: 9783030499280
Language: EN, FR, DE, ES & NL

The Fungal Cell Wall Book Review:

This book illustrates, that the fungal cell wall is critical for the biology and ecology of all fungi and especially for human fungal pathogens. Readers will learn, that the composition of the fungal cell wall is a unique structure, which cannot be found in the human host. Consequently, the chapters outline, how the immune systems of both animals and humans have evolved to recognize conserved and unique elements of the fungal cell wall. As an application example, the authors also show, that the three-dimensional structures of the cell wall are excellent targets for the development of antifungal agents and chemotherapeutic strategies. With the combination of biological findings and medical outlooks, this volume is a fascinating read for scientists, clinicians and biomedical students.

Antimicrobial Compounds

Antimicrobial Compounds
Author: Tomás G. Villa,Patricia Veiga-Crespo
Publsiher: Springer Science & Business Media
Total Pages: 316
Release: 2013-10-19
ISBN 10: 3642404448
ISBN 13: 9783642404443
Language: EN, FR, DE, ES & NL

Antimicrobial Compounds Book Review:

Since penicillin and salvarsan were discovered, a number of new drugs to combat infectious diseases have been developed, but at the same time, the number of multi-resistant microorganism strains is increasing. Thus, the design of new and effective antibacterial, antiviral and antifungal agents will be a major challenge in the next years. This book reviews the current state-of-the-art in antimicrobial research and discusses new strategies for the design and discovery of novel therapies. Topics covered include the use of genetic engineering, genome mining, manipulation of gene clusters, X-ray and neutron scattering as well as the antimicrobial effects of essential oils, antimicrobial agents of plant origin, beta-lactam antibiotics, antimicrobial peptides, and cell-wall-affecting antifungal antibiotics.

Emerging Targets in Antibacterial and Antifungal Chemotherapy

Emerging Targets in Antibacterial and Antifungal Chemotherapy
Author: Joyce Sutcliffe,Nafsika Georgopapadakou
Publsiher: Springer Science & Business Media
Total Pages: 606
Release: 2012-12-06
ISBN 10: 1461532744
ISBN 13: 9781461532743
Language: EN, FR, DE, ES & NL

Emerging Targets in Antibacterial and Antifungal Chemotherapy Book Review:

Emerging Targets in Antibacterial and Antifungal Chemotherapy offers constructive ideas to researchers that could lead to the discovery of entirely new classes of drugs. The authors emphasize new topics rather than review work on known antibacterials and antifungals, and identify new targets--either the rate-limiting component of a biochemical pathway or a component of the pathway that is susceptible to a ``screening'' or ``rational drug design'' approach. Each chapter reviews the biochemical pathway and its place in the cellular scheme in order to place the target in perspective. The authors, a mixture of academic researchers and drug-discovery investigators in pharmaceutical companies, also extend these theoretical concerns into practical applications and suggest useful screening methodologies. The importance of this subject area is demonstrated by the increasing number of papers in the literature that point to potential targets and screening methodologies for new antibacterials. This book also deals with antifungals, investigating the inherent limitations in existing antifungals (many of which are extremely toxic or have only limited efficacy), and pointing to major developments in the discovery of novel antifungals. Emerging Targets in Antibacterial and Antifungal Chemotherapy will be of interest to professional microbiologists, biochemists, and cell biologists in both academic and industrial laboratories.

Vulvovaginal Candidosis

Vulvovaginal Candidosis
Author: Werner Mendling
Publsiher: Springer Science & Business Media
Total Pages: 171
Release: 2012-12-06
ISBN 10: 3642833128
ISBN 13: 9783642833120
Language: EN, FR, DE, ES & NL

Vulvovaginal Candidosis Book Review:

Fungal infections in the female play an increasingly large role in everyday gynecological practice. This is the first book to deal comprehensively with vulvovaginal candidosis. Following an introduction outlining the incidence of yeasts in man, genital colonization in the female sex, yeast in pregnancy and neonatal mycoses, there is a description of the modes of infection and the known host reactions, as well as of the symptoms for diagnosis and therapy. Some 150 color illustrations depict all known facultative pathogenetic candida species and other potentially pathogenetic yeasts in pure culture and under the microscope. Clinical examples help explain the diagnosis and differential diagnosis. The volume provides the physician with handy, concise and practice-oriented guidelines to correct diagnosis and effective treatment of yeasts in the female patient.

Antibacterial and Antifungal Drug Discovery Benzimidazole Derivatives

Antibacterial and Antifungal Drug Discovery  Benzimidazole Derivatives
Author: Muhammad Imran,Muhammad Asim Farid,Muhammad Adnan Asghar
Publsiher: LAP Lambert Academic Publishing
Total Pages: 84
Release: 2015-06-29
ISBN 10: 9783659750588
ISBN 13: 3659750581
Language: EN, FR, DE, ES & NL

Antibacterial and Antifungal Drug Discovery Benzimidazole Derivatives Book Review:

Drug discovery is a vast area of research due to increase in bacterial and fungal resistance against available drugs. This book will give the basic concepts of Schiff-Mannich Base derivatives of Benzimidazole, Metal complexes and their application in the field of drug discovery. It will also provide the basic mechanistic study as well as the knowledge about characterization techniques which will be helpful for young students and researchers to have a deep insight about Antibacterial and Antifungal agents.