Adenoviral Vectors for Gene Therapy

Adenoviral Vectors for Gene Therapy
Author: David T. Curiel
Publsiher: Academic Press
Total Pages: 868
Release: 2016-03-10
ISBN 10: 0128005106
ISBN 13: 9780128005101
Language: EN, FR, DE, ES & NL

Adenoviral Vectors for Gene Therapy Book Review:

Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research. This book presents topics ranging from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models, with final consideration of the regulatory issues surrounding human clinical gene therapy trials. This broad scope of information provides a solid overview of the field, allowing the reader to gain a complete understanding of the development and use of adenoviral vectors. Provides complete coverage of the basic biology of adenoviruses, as well as their construction, propagation, and purification of adenoviral vectors Introduces common strategies for the development of adenoviral vectors, along with cutting-edge methods for their improvement Demonstrates noninvasive imaging of adenovirus-mediated gene transfer Discusses utility of adenoviral vectors in animal disease models Considers Federal Drug Administration regulations for human clinical trials

Adenoviral Vectors for Gene Therapy

Adenoviral Vectors for Gene Therapy
Author: David T. Curiel,Joanne T. Douglas
Publsiher: Academic Press
Total Pages: 730
Release: 2002-05
ISBN 10: 9780121995041
ISBN 13: 0121995046
Language: EN, FR, DE, ES & NL

Adenoviral Vectors for Gene Therapy Book Review:

Adenoviral Vectors for Gene Therapy provides detailed and comprehensive coverage of these important therapeutic agents. The topics covered in this book range from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology and the use of adenoviral vectors in preclinical animal models, to regulatory issues which must be considered prior to the initiation of human clinical gene therapy trials. The broad scope of this unique volume provides the reader with a complete understanding of the development and use of adenoviral vectors. Key Features * Provides complete coverage of basic biology of adenoviruses, as well as the construction, propagation and purification of adenoviral vectors * Introduces common strategies for the development of adenoviral vectors along with cutting-edge methods for their improvement * Demonstrates noninvasive imaging of adenovirus-mediated gene transfer * Discusses utility of adenoviral vectors in animal disease models * Considers Federal Drug Administration regulations for human clinical trials

Viral Vectors for Gene Therapy

Viral Vectors for Gene Therapy
Author: Fredric P. Manfredsson,Matthew J. Benskey
Publsiher: Unknown
Total Pages: 328
Release: 2019
ISBN 10: 9781493990658
ISBN 13: 1493990659
Language: EN, FR, DE, ES & NL

Viral Vectors for Gene Therapy Book Review:

This volume discusses protocols, ranging from vector production to delivery methods, used to execute gene therapy applications. Chapters are divided into four parts, and cover topics such as design, construction, and application of transcription activation-like effectors; multi-modal production of adeno-associated virus; construction of oncolytic herpes simplex virus; AAV-mediated gene delivery to the mouse liver; and intrathecal delivery of gene therapeutics by direct lumbar puncture in mice. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and authoritative, Viral Vectors for Gene Therapy: Methods and Protocols is a valuable resource for researchers, clinicians, and students looking to utilize viral vectors in gene therapy experiments.

Therapeutic Applications of Adenoviruses

Therapeutic Applications of Adenoviruses
Author: Philip Ng,Nicola Brunetti-Pierri
Publsiher: CRC Press
Total Pages: 256
Release: 2016-12-12
ISBN 10: 1315351803
ISBN 13: 9781315351803
Language: EN, FR, DE, ES & NL

Therapeutic Applications of Adenoviruses Book Review:

Adenoviruses are double stranded DNA viruses that have been used to study the process of DNA replication. Studies of the mode of action of adenovirally produced tumors in rodents led to the discovery of tumour supressor genes. The adenoviral vector is now the most used vector in clinical gene therapy especially for some kinds of cancers. The chapters in this book focus on the most up-to-date developments in the therapeutic applications of adenoviruses. The intended audience is individuals in the Life Sciences interested in therapeutic applications of adenoviruses. This book reviews the life history and immune responses to adenoviruses and summarizes various therapies implemented with the use of adenoviruses.

A Guide to Human Gene Therapy

A Guide to Human Gene Therapy
Author: Roland W. Herzog,Sergei Zolotukhin
Publsiher: World Scientific
Total Pages: 388
Release: 2010
ISBN 10: 9814280917
ISBN 13: 9789814280914
Language: EN, FR, DE, ES & NL

A Guide to Human Gene Therapy Book Review:

Ever since the birth of molecular biology, the tantalizing possibility of treating disease at its genetic roots has become increasingly feasible. Gene therapy - though still in its infancy - remains one of the hottest areas of research in medicine. Its approach utilizes a gene transfer vehicle ( vector) to deliver therapeutic DNA or RNA to cells of the body in order to rectify the defect that is causing the disease. Successful therapies have been reported in humans in recent years such as cures in boys with severe immune deficiencies. Moreover, gene therapy strategies are being adapted in numerous biomedical laboratories to obtain novel treatments for a variety of diseases and to study basic biological aspects of disease. Correction of disease in animal studies, is steadily gaining ground, highlighting the immense potential of gene therapy in the medical profession. This book will cover topics that are at the forefront of biomedical research such as RNA interference, viral and non-viral gene transfer systems, treatment of hematological diseases and disorders of the central nervous system.Leading experts on the respective vector or disease will contribute the individual chapters and explain cutting-edge technologies. It also gives a broad overview of the most important gene transfer vectors and most extensively studied target diseases. This comprehensive guide is therefore a must-read for anyone in the biotechnology, biomedical or medical industries seeking to further their knowledge in the area of human gene therapy.

Cancer Gene Therapy

Cancer Gene Therapy
Author: David T. Curiel,Joanne T. Douglas
Publsiher: Springer Science & Business Media
Total Pages: 490
Release: 2007-11-03
ISBN 10: 1592597858
ISBN 13: 9781592597857
Language: EN, FR, DE, ES & NL

Cancer Gene Therapy Book Review:

A complete introduction and guide to the latest developments in cancer gene therapy-from bench to bedside. The authors comprehensively review the anticancer genes and gene delivery methods currently available for cancer gene therapy, including the transfer of genetic material into the cancer cells, stimulation of the immune system to recognize and eliminate cancer cells, and the targeting of the nonmalignant stromal cells that support their growth. They also thoroughly examine the advantages and limitations of the different therapies and detail strategies to overcome obstacles to their clinical implementation. Topics of special interest include vector-targeting techniques, the lessons learned to date from clinical trials of cancer gene therapy, and the regulatory guidelines for future trials. Noninvasive techniques to monitor the extent of gene transfer and disease regression during the course of treatment are also discussed.

Holland Frei Cancer Medicine

Holland Frei Cancer Medicine
Author: Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Publsiher: John Wiley & Sons
Total Pages: 2008
Release: 2017-03-10
ISBN 10: 111900084X
ISBN 13: 9781119000846
Language: EN, FR, DE, ES & NL

Holland Frei Cancer Medicine Book Review:

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Viral Vectors for Gene Therapy

Viral Vectors for Gene Therapy
Author: Otto-Wilhelm Merten,Mohamed Al-Rubeai
Publsiher: Humana Press
Total Pages: 450
Release: 2011-05-19
ISBN 10: 9781617790942
ISBN 13: 161779094X
Language: EN, FR, DE, ES & NL

Viral Vectors for Gene Therapy Book Review:

The huge potential for gene therapy to cure a wide range of diseases has led to high expectations and a great increase in research efforts in this area, particularly in the study of delivery via viral vectors, widely considered to be more efficient than DNA transfection. In Viral Vectors for Gene Therapy: Methods and Protocols, experts in the field present a collection of their knowledge and experience featuring methodologies that involve virus production, transferring protocols, and evaluating the efficacy of gene products. While thoroughly covering the most popular viral vector systems of adenovirus, retrovirus, and adeno-associated virus, this detailed volume also explores less common viral vector systems such as baculovirus, herpes virus, and measles virus, the growing interest in which is creating a considerable demand for large scale manufacturing and purification procedures. Written in the highly successful Methods in Molecular BiologyTM series format, many chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and vital tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Viral Vectors for Gene Therapy: Methods and Protocols provides basic principles accessible to scientists from a wide variety of backgrounds for the development of gene therapy viral products that are safe and effective.

Adeno Associated Virus AAV Vectors in Gene Therapy

Adeno Associated Virus  AAV  Vectors in Gene Therapy
Author: Kenneth I. Berns,Catherine Giraud
Publsiher: Springer Science & Business Media
Total Pages: 173
Release: 2012-12-06
ISBN 10: 3642802079
ISBN 13: 9783642802072
Language: EN, FR, DE, ES & NL

Adeno Associated Virus AAV Vectors in Gene Therapy Book Review:

Human gene therapy holds great promise for the cure of many genetic diseases. In order to achieve such a cure there are two requirements. First, the affected gene must be cloned, its se quence determined and its regulation adequately characterized. Second, a suitable vector for the delivery of a good copy of the affected gene must be available. For a vector to be of use several attributes are highly desirable: these include ability to carry the intact gene (although this may be either the genomic or the cDNA form) in a stable form, ability to introduce the gene into the desired cell type, ability to express the introduced gene in an appropriately regulated manner for an extended period of time, and a lack of toxicity for the recipient. Also of concern is the frequency of cell transformation and, in some cases, the ability to introduce the gene into nondividing stem cells. Sev eral animal viruses have been tested as potential vectors, but none has proven to have all the desired properties described above. For example, retroviruses are difficult to propagate in sufficient titers, do not integrate into nondividing cells, and are of concern because of their oncogenic properties in some hosts and because they integrate at many sites in the genome and, thus, are potentially insertional mutagens. Additionally, genes introduced by retroviral vectors are frequently expressed for relatively short periods of time. A second virus used as a vector in model systems has been adenovirus (Ad).

Gene Therapy for Cancer

Gene Therapy for Cancer
Author: Kelly K. Hunt,Stephan A. Vorburger,Stephen G. Swisher
Publsiher: Springer Science & Business Media
Total Pages: 469
Release: 2007-10-26
ISBN 10: 159745222X
ISBN 13: 9781597452229
Language: EN, FR, DE, ES & NL

Gene Therapy for Cancer Book Review:

The three sections of this volume present currently available cancer gene therapy techniques. Part I describes the various aspects of gene delivery. In Part II, the contributors discuss strategies and targets for the treatment of cancer. Finally, in Part III, experts discuss the difficulties inherent in bringing gene therapy treatment for cancer to the clinic. This book will prove valuable as the volume of preclinical and clinical data continues to increase.

Novel Technologies for Vaccine Development

Novel Technologies for Vaccine Development
Author: Igor S Lukashevich,Haval Shirwan
Publsiher: Springer
Total Pages: 386
Release: 2014-11-13
ISBN 10: 3709118182
ISBN 13: 9783709118184
Language: EN, FR, DE, ES & NL

Novel Technologies for Vaccine Development Book Review:

This book presents a detailed overview of the development of new viral vector-based vaccines before discussing two major applications: preventive vaccines for infectious diseases and therapeutic cancer vaccines. Viral vector-based vaccines hold a great potential for development into successful pharmaceutical products and several examples at the advanced pre-clinical or clinical stage are presented. Nevertheless, the most efforts were focused on novel and very innovative technologies for new generation of vector-based vaccines. Furthermore, specific topics such as delivery and adjuvant and protection strategies for cell-mediated-based vaccines are presented. Given its scope, the book is a “must read” for all those involved in vaccine development, both in academia and industrial vaccine development.

Genes and Resistance to Disease

Genes and Resistance to Disease
Author: Kåre Berg,World Health Organization
Publsiher: Springer Science & Business Media
Total Pages: 204
Release: 2000
ISBN 10: 9783540667247
ISBN 13: 3540667245
Language: EN, FR, DE, ES & NL

Genes and Resistance to Disease Book Review:

The advances in human genetics that have ocurred during the past 20 years have revolutionized our knowledge of the role played by inheritance in health and disase. It is clear that our DNA determines not only the emergence of catastrophic single-gene disorders, which affect millions of persons worldwide, but also interacts with environments to predispose individuals to cancer, allergy, hypertension, heart disease, diabetes, psychiatric disorders and even to some infectious diseases. Overall, the study of longevity and the demonstration of genes favouring a long lifespan suggest that such protective systems exist. In recent years, the study of genetic polymorphisms has made clear that some alleles have beneficial effects. These discoveries can substantially improve our understanding of the interactions between genetics and the environment, between pathogenetic mechanisms and new treatments.

Targets in Gene Therapy

Targets in Gene Therapy
Author: Yongping You
Publsiher: BoD – Books on Demand
Total Pages: 448
Release: 2011-08-23
ISBN 10: 9533075406
ISBN 13: 9789533075402
Language: EN, FR, DE, ES & NL

Targets in Gene Therapy Book Review:

This book aims at providing an up-to-date report to cover key aspects of existing problems in the emerging field of targets in gene therapy. With the contributions in various disciplines of gene therapy, the book brings together major approaches: Target Strategy in Gene Therapy, Gene Therapy of Cancer and Gene Therapy of Other Diseases. This source enables clinicians and researchers to select and effectively utilize new translational approaches in gene therapy and analyze the developments in target strategy in gene therapy.

Immunopharmacology

Immunopharmacology
Author: Manzoor M. Khan
Publsiher: Springer Science & Business Media
Total Pages: 266
Release: 2008-12-19
ISBN 10: 9780387779768
ISBN 13: 0387779760
Language: EN, FR, DE, ES & NL

Immunopharmacology Book Review:

During the past decades, with the introduction of the recombinant DNA, hybridoma and transgenic technologies there has been an exponential evolution in understanding the pathogenesis, diagnosis and treatment of a large number of human diseases. The technologies are evident with the development of cytokines and monoclonal antibodies as therapeutic agents and the techniques used in gene therapy. Immunopharmacology is that area of biomedical sciences where immunology, pharmacology and pathology overlap. It concerns the pharmacological approach to the immune response in physiological as well as pathological events. This goals and objectives of this textbook are to emphasize the developments in immunology and pharmacology as they relate to the modulation of immune response. The information includes the pharmacology of cytokines, monoclonal antibodies, mechanism of action of immune-suppressive agents and their relevance in tissue transplantation, therapeutic strategies for the treatment of AIDS and the techniques employed in gene therapy. The book is intended for health care professional students and graduate students in pharmacology and immunology.

Gene Therapy

Gene Therapy
Author: Mauro Giacca
Publsiher: Springer Science & Business Media
Total Pages: 303
Release: 2010-11-01
ISBN 10: 8847016436
ISBN 13: 9788847016439
Language: EN, FR, DE, ES & NL

Gene Therapy Book Review:

I entered the gene therapy field in the mid-1990s, being fascinated by the immense potential of genes as drugs for the treatment of human disease. Since then, I have experienced the ups and downs of this discipline, and tried to contribute with my work and that of my laboratory to the development of innovative approaches to the treatment of cardiovascular disorders. During these years, I have had several opp- tunities to speak on gene therapy at lectures and academic lessons, and have often noticed that the field is very attractive to scientists of all disciplines. However, as yet no comprehensive book on the subject has been published. Indeed, most books in the field are either a collection of gene transfer laboratory protocols or deal with the subject in a rather superficial manner. Hence the idea to write a gene therapy textbook that is broad and comprehensive, but at the same time provides sufficient molecular and clinical detail to be of interest to students, professors, and specialists in the various disciplines that contribute to gene therapy. I have tried to keep the language plain and, whenever possible, non-technical. Since the book is intended to be a textbook in the field of gene therapy in both the basic science and clinical areas, whenever technical descriptions are required, they are provided.

Safety and Efficacy of Gene Based Therapeutics for Inherited Disorders

Safety and Efficacy of Gene Based Therapeutics for Inherited Disorders
Author: Nicola Brunetti-Pierri
Publsiher: Springer
Total Pages: 220
Release: 2017-05-22
ISBN 10: 3319534572
ISBN 13: 9783319534572
Language: EN, FR, DE, ES & NL

Safety and Efficacy of Gene Based Therapeutics for Inherited Disorders Book Review:

In this book, leading international experts analyze state-of-the-art advances in gene transfer vectors for applications in inherited disorders and also examine the toxicity profiles of these methods. The authors discuss the strengths and weaknesses of available vectors in the clinical setting, and specifically focus on the challenges and possible solutions that researchers are testing in order to improve the safety of gene therapy for genetic diseases. This comprehensive and authoritative overview of vector development is a necessary text for researchers, toxicologists, pharmacologists, molecular biologists, physicians, and students in these fields.

Gene Therapy for Viral Infections

Gene Therapy for Viral Infections
Author: Patrick Arbuthnot
Publsiher: Academic Press
Total Pages: 392
Release: 2015-06-01
ISBN 10: 0124114520
ISBN 13: 9780124114524
Language: EN, FR, DE, ES & NL

Gene Therapy for Viral Infections Book Review:

Gene Therapy for Viral Infections provides a comprehensive review of the broader field of nucleic acid and its use in treating viral infections. The text bridges the gap between basic science and important clinical applications of the technology, providing a systematic, integrated review of the advances in nucleic acid-based antiviral drugs and the potential advantages of new technologies over current treatment options. Coverage begins with the fundamentals, exploring varying topics, including harnessing RNAi to silence viral gene expression, antiviral gene editing, viral gene therapy vectors, and non-viral vectors. Subsequent sections include detailed coverage of the developing use of gene therapy for the treatment of specific infections, the principles of rational design of antivirals, and the hurdles that currently face the further advancement of gene therapy technology. Provides coverage of gene therapy for a variety of infections, including HBV, HCV, HIV, hemorrhagic fever viruses, and respiratory and other viral infections Bridges the gap between the basic science and the important medical applications of this technology Features a broad approach to the topic, including an essential overview and the applications of gene therapy, synthetic RNA, and other antiviral strategies that involve nucleic acid engineering Presents perspectives on the future use of nucleic acids as a novel class of antiviral drugs Arms the reader with the cutting-edge information needed to stay abreast of this developing field

Viral Vectors for Gene Therapy

Viral Vectors for Gene Therapy
Author: Curtis A. Machida
Publsiher: Springer Science & Business Media
Total Pages: 608
Release: 2003
ISBN 10: 1592593046
ISBN 13: 9781592593040
Language: EN, FR, DE, ES & NL

Viral Vectors for Gene Therapy Book Review:

Comprehensive and highly practical, Viral Vectors for Gene Therapy provides researchers with the basic tools needed to design targeted gene delivery vectors, and clinicians with an understanding of how to apply viral vectors to the treatment of genetic disorders. Offering detailed step-by-step instructions to ensure successful results, these experts detail the use of herpes viruses, adenoviruses, adeno-associated viruses, simple and complex retroviruses, including lentiviruses, and other virus systems for vector development and gene transfer. Additional chapters demonstrate the use of virus vectors in the brain and central nervous system.

Muscle Gene Therapy

Muscle Gene Therapy
Author: Dongsheng Duan
Publsiher: Springer Science & Business Media
Total Pages: 275
Release: 2009-11-26
ISBN 10: 144191207X
ISBN 13: 9781441912077
Language: EN, FR, DE, ES & NL

Muscle Gene Therapy Book Review:

Muscle disease represents an important health threat to the general population. There is essentially no cure. Gene therapy holds great promise to correct the genetic defects and eventually achieve full recovery in these diseases. Significant progresses have been made in the field of muscle gene therapy over the last few years. The development of novel gene delivery vectors has substantially enhanced specificity and efficiency of muscle gene delivery. The new knowledge on the immune response to viral vectors has added new insight in overcoming the immune obstacles. Most importantly, the field has finally moved from small experimental animal models to human patients. This book will bring together the leaders in the field of muscle gene transfer to provide an updated overview on the progress of muscle gene therapy. It will also highlight important clinical applications of muscle gene therapy.

Heterologous Immunity Implications and Applications in Vaccines and Immunotherapies

Heterologous Immunity  Implications and Applications in Vaccines and Immunotherapies
Author: Babita Agrawal,Stephanie Yanow,Shakti Singh
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2020-08-27
ISBN 10: 2889639657
ISBN 13: 9782889639656
Language: EN, FR, DE, ES & NL

Heterologous Immunity Implications and Applications in Vaccines and Immunotherapies Book Review: