Pathophysiology of Ischemia Reperfusion Injury and Use of Fingolimod in Cardioprotection

Pathophysiology of Ischemia Reperfusion Injury and Use of Fingolimod in Cardioprotection
Author: Naseer Ahmed
Publsiher: Academic Press
Total Pages: 140
Release: 2019-05-30
ISBN 10: 0128182539
ISBN 13: 9780128182536
Language: EN, FR, DE, ES & NL

Pathophysiology of Ischemia Reperfusion Injury and Use of Fingolimod in Cardioprotection Book Review:

Pathophysiology of Ischemia-Reperfusion Injury and Use of Fingolimod in Cardioprotection is a deep examination into the mechanisms of myocardial ischemiareperfusion injury and role of fingolimod as a cardioprotective agent through its antioxidant, anti-apoptotic and anti-inflammatory effects. Dr. Ahmed explore the physiology and pathophysiology of myocardial metabolism under normal and ischemic conditions and focused on pharmacological cardioprotection. They provide a concise, yet rigorous discussion of Ischemia-Reperfusion Injury, Myocardial Ischemia during Circulatory Arrest, Myocardial Reperfusion, Myocardial Protection related to Ischemia-Reperfusion Injury and Role of Fingolimod in Cardioprotection. Pathophysiology of Ischemia-Reperfusion Injury and Use of Fingolimod in Cardioprotection is ideal for researchers, cardiovascular scientists, and clinical pharmacologists to further work in this challenging area and apply this knowledge to clinical trials for cardioprotection. Provides detailed and critical analysis of the latest research in the field from molecular basis to potential clinical relevance Examines the effect of fingolimod/sphingosine 1-phosphate in cardioprotection, pointing to future myocardial preventative strategies

Novel Therapeutic Targets and Emerging Treatments for Fibrosis

Novel Therapeutic Targets and Emerging Treatments for Fibrosis
Author: Chrishan S. Samuel,Timothy D. Hewitson
Publsiher: Frontiers Media SA
Total Pages: 329
Release: 2018-01-12
ISBN 10: 2889453723
ISBN 13: 9782889453726
Language: EN, FR, DE, ES & NL

Novel Therapeutic Targets and Emerging Treatments for Fibrosis Book Review:

For decades we have known that the overgrowth, hardening and scarring of tissues (so-called fibrosis) represents the final common pathway and best histological predictor of disease progression in most organs. Fibrosis is the culmination of both excess extracellular matrix deposition due to ongoing or severe injury, and a failure to regenerate. An inadequate wound repair process ultimately results in organ failure through a loss of function, and is therefore a major cause of morbidity and mortality in disease affecting both multiple and individual organs. Whilst the pathology of fibrosis and its significance are well understood, until recently we have known little about its molecular regulation. Current therapies are often indirect and non-specific, and only slow progression by a matter of months. The recent identification of novel therapeutic targets, and the development of new treatment strategies based on them, offers the exciting prospect of more efficacious therapies to treat this debilitating disorder. This Research Topic therefore compromises several up-to-date mini-reviews on currently known and emerging therapeutic targets for fibrosis including: the Transforming Growth Factor (TGF)-family; epigenetic factors; Angiotensin II type 2 (AT2) receptors; mineralocorticoid receptors; adenosine receptors; caveolins; and the sphingosine kinase/sphingosine 1-phosphate and notch signaling pathways. In each case, mechanistic insights into how each of these factors contribute to regulating fibrosis progression are described, along with how they can be targeted (by existing drugs, small molecules or other mimetics) to prevent and/or reverse fibrosis and its contribution to tissue dysfunction and failure. Two additional reviews will discuss various anti-fibrotic therapies that have demonstrated efficacy at the experimental level, but are not yet clinically approved; and the therapeutic potential vs limitations of stem cell-based therapies for reducing fibrosis while facilitating tissue repair. Finally, this Research Topic concludes with a clinical perspective of various anti-fibrotic therapies for cardiovascular disease (CVD), outlining limitations of currently used therapies, the pipeline of anti-fibrotics for CVD and why so many anti-fibrotic drugs have failed at the clinical level.

Mechanisms of Vascular Disease

Mechanisms of Vascular Disease
Author: Robert Fitridge,Matthew Thompson
Publsiher: University of Adelaide Press
Total Pages: 587
Release: 2011-01-01
ISBN 10: 1922064009
ISBN 13: 9781922064004
Language: EN, FR, DE, ES & NL

Mechanisms of Vascular Disease Book Review:

New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.

Cardioprotection

Cardioprotection
Author: Derek Hausenloy,Derek Yellon
Publsiher: Oxford University Press
Total Pages: 126
Release: 2009-08-20
ISBN 10: 019954476X
ISBN 13: 9780199544769
Language: EN, FR, DE, ES & NL

Cardioprotection Book Review:

Coronary heart disease (CHD) is the leading cause of death worldwide. Cardioprotection refers to the prevention of CHD and the clinical improvement in patients suffering from cardiovascular problems.

Cerebral Ischemic Reperfusion Injuries (CIRI)

Cerebral Ischemic Reperfusion Injuries (CIRI)
Author: Weijian Jiang,Wengui Yu,Yan Qu,Zhongsong Shi,Benyan Luo,John H. Zhang
Publsiher: Springer
Total Pages: 259
Release: 2018-06-29
ISBN 10: 331990194X
ISBN 13: 9783319901947
Language: EN, FR, DE, ES & NL

Cerebral Ischemic Reperfusion Injuries (CIRI) Book Review:

This volume is focused on subjects related to cerebral ischemia and reperfusion injuries after acute stroke. All chapters are selected from the Sixth Elite Stroke meeting named Pangu Stroke Conference and written by members of world leading laboratories of stroke studies. The contents cover both clinical and bench studies, from basic components of cerebral arterial system to clinical reperfusion injury cases, from reperfusion caused programmed cell death and astrocyte activation to oxidative stress and nitric oxide after reperfusion, from extracellular matrix and inflammation to a role of diabetes after reperfusion, from small artery disorders to collateral circulation and blood pressure control after reperfusion. Wei-Jian Jiang, Chairman of New Era Stroke Care and Research Institute of PLA Rocket Force General Hospital, Beijing, China. Wengui Yu, Professor and Director of Comprehensive Stroke & Cerebrovascular Center, University of California, Irvine Yan Qu, Professor and Director of Neurosurgery at the Second Affiliated Hospital of Air Force Medical University, Xi’an, China. Zhongsong Shi, Professor of Neurosurgery at Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. Ben-yan Luo, Professor and Chair of Neurology at the First Affiliated Hospital of Zhejiang University. John H. Zhang, Professor of Anesthesiology and Physiology at Loma Linda University School of Medicine, Loma Linda, CA, USA.

Sudden arrhythmic death: from basic science to clinical practice

Sudden arrhythmic death: from basic science to clinical practice
Author: Gareth D. Matthews
Publsiher: Frontiers E-books
Total Pages: 329
Release: 2014-10-02
ISBN 10: 2889192695
ISBN 13: 9782889192694
Language: EN, FR, DE, ES & NL

Sudden arrhythmic death: from basic science to clinical practice Book Review:

With upwards of 4.5 million deaths worldwide each year, and more than one tenth of these occurring in those with no previously documented heart disease, sudden arrhythmic death (SAD) is both a major public health burden and a highly emotive issue for society at large. Recent years have witnessed a marked expansion in our knowledge of the physiology underlying SAD, both in the context of hereditary and acquired cardiac disorders. Thanks largely to work in genetically modified animals, the growth in our understanding of mechanisms underlying arrhythmia in the hereditary channelopathies has been particularly marked. Our growing knowledge of the fundamental mechanisms underlying SAD has so far failed to spur substantial developments in clinical practice. Despite a large body of work in both humans and animals, it remains impossible to confidently identify those at high risk of SAD, making pre-emptive therapy a challenge. What is more, with the thankful exception of the implantable cardioverter-defibrillators and pharmacological agents in very specific situations, there has been depressingly little progress in finding new and effective therapies. This Research Topic aims to go some way towards bridging the gap between advances in basic science and the development and delivery of new therapies. It brings together original research contributions and review articles from key opinion leaders in the field, focusing on the direct clinical implications of the basic science research now and in the future

Kashmir Pending

Kashmir Pending
Author: Naseer Ahmed
Publsiher: Anonim
Total Pages: 95
Release: 2007
ISBN 10:
ISBN 13: UOM:39015076865206
Language: EN, FR, DE, ES & NL

Kashmir Pending Book Review:

Mitochondria in Obesity and Type 2 Diabetes

Mitochondria in Obesity and Type 2 Diabetes
Author: Beatrice Morio,Luc Penicaud,Michel Rigoulet
Publsiher: Academic Press
Total Pages: 736
Release: 2019-04-15
ISBN 10: 0128117524
ISBN 13: 9780128117521
Language: EN, FR, DE, ES & NL

Mitochondria in Obesity and Type 2 Diabetes Book Review:

Mitochondria in Obesity and Type 2 Diabetes: Comprehensive Review on Mitochondrial Functioning and Involvement in Metabolic Diseases synthesizes discoveries from laboratories around the world, enhancing our understanding of the involvement of mitochondria in the etiology of diseases, such as obesity and type 2 diabetes. Chapters illustrate and provide an overview of key concepts on topics such as the role of mitochondria in adipose tissue, cancer, cardiovascular comorbidities, skeletal muscle, the liver, kidney, and more. This book is a must-have reference for students and educational teams in biology, physiology and medicine, and researchers. Synthesizes actual knowledge on mitochondrial function Provides an integrated vision of each tissue in the etiology of obesity and type 2 diabetes Identifies the interactive networks that involve alteration in mitochondrial mass and function in disease progression Highlights the role played by mitochondria in the prevention and treatment of obesity and type 2 diabetes

The Role of Bioactive Lipids in Cancer, Inflammation and Related Diseases

The Role of Bioactive Lipids in Cancer, Inflammation and Related Diseases
Author: Kenneth V. Honn,Darryl C. Zeldin
Publsiher: Springer Nature
Total Pages: 257
Release: 2019-09-27
ISBN 10: 3030217353
ISBN 13: 9783030217358
Language: EN, FR, DE, ES & NL

The Role of Bioactive Lipids in Cancer, Inflammation and Related Diseases Book Review:

The Organizing Committee of the 15th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases compiled a group of junior investigators to provide reviews on the topics they presented at the Puerto Vallarta Bioactive Lipids conference, as part of the book series, Advances in Experimental Medicine and Biology (AEMB). The book in this series will be titled Bioactive Lipids in Cancer, Inflammation and Related Diseases. Topics range from all classes of lipids including prostaglandins, resolvins, spingolipids, P450-derived lipids, endocannabanoids and phospholipids. The focus includes physiology, cell biology, and structural studies in organisms from bacteria to humans and how these studies addressed the role of lipids in various disease i.e. cancer, inflammation, diabetes, obesity, cardiovascular disease and others.

The Adenosine Receptors

The Adenosine Receptors
Author: Pier Andrea Borea,Katia Varani,Stefania Gessi,Stefania Merighi,Fabrizio Vincenzi
Publsiher: Humana Press
Total Pages: 593
Release: 2018-07-28
ISBN 10: 3319908081
ISBN 13: 9783319908083
Language: EN, FR, DE, ES & NL

The Adenosine Receptors Book Review:

This book traces the history of adenosine receptor research from molecular biology to medicinal chemistry to behavior, including their implications in disease and potential strategies as therapeutic targets. It provides the reader with a comprehensive overview of the adenosine receptors that includes information on all subtypes - A1, A2A, A2B and A3. Aspects addressed include the most up to date information on their functional distribution in the nervous and peripheral systems, behavioral roles in inflammation, cancer, pain and neurological diseases such as Huntington’s disease, Epilepsy, Parkinson’s disease and Alzheimer’s disease.

Phytopharmaceuticals for Brain Health

Phytopharmaceuticals for Brain Health
Author: Shahnaz Subhan,Manashi Bagchi
Publsiher: CRC Press
Total Pages: 444
Release: 2017-09-27
ISBN 10: 1351649035
ISBN 13: 9781351649032
Language: EN, FR, DE, ES & NL

Phytopharmaceuticals for Brain Health Book Review:

Research studies demonstrate diet and proper nutrition in conjunction with cognitive, mental, social, and physical activities can significantly help in improving brain health with advancing age, and potentially reduce the risk of cognitive decline. These studies of phytopharmaceuticals and medicinal plants, demonstrate the efficacy of Huperzine A, berry anthocyanins, trans-resveratrol, Ginkgo biloba, Bacopa monniera, Centella asiatica, tocotrienols, and palm oil in boosting brain health and physical well-being. In addition, consumption of marine fishes and general seafood is recommended for long-term nutritional intervention to preserve mental health, hinder neurodegenerative processes, and sustain cognitive capacities in humans. Omega-3 and omega-6 polyunsaturated fatty acids, n-3/n-6 PUFAs, flavonoids, and antioxidants prevent the initiation and progression of many neurological disorders. This book is a comprehensive review of phytopharmaceuticals impacting brain health with emphasis on diverse applications in food and nutrition sciences, biomedicine, neurology and other scientific and medical fields. It details available methods and contains numerous references making this the perfect guide for scientists who want to explore the fascinating world of phytopharmaceuticals with relation to brain health. Phytopharmaceuticals for Brain Health appeals to a diverse range of readers in industry, medical doctors, research and academia, including biologists, biochemists, food scientists, nutritionists and health professionals. Overall, this book brings a classic scenario of neurological problems to possible amelioration using novel nutraceuticals and functional foods.

Pocket Obstetrics and Gynecology

Pocket Obstetrics and Gynecology
Author: K. Joseph Hurt
Publsiher: Lippincott Williams & Wilkins
Total Pages: 338
Release: 2018-11-26
ISBN 10: 1496367014
ISBN 13: 9781496367013
Language: EN, FR, DE, ES & NL

Pocket Obstetrics and Gynecology Book Review:

Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. This practical, high-yield Pocket Notebook title is an ideal on-the-go reference for trainees and practitioners of obstetrics and gynecology. Written by residents with oversight from fellows and faculty experts, and perfect for initial care plans during rounds, this easy-to-use, loose-leaf resource is packed with up-to-date information answering the clinical questions you face every day. Pocket Obstetrics and Gynecology, Second Edition, is an indispensable quick resource you won’t want to be without!

Stem Cells

Stem Cells
Author: Mariusz Z. Ratajczak
Publsiher: Springer Nature
Total Pages: 329
Release:
ISBN 10: 3030312062
ISBN 13: 9783030312060
Language: EN, FR, DE, ES & NL

Stem Cells Book Review:

Nanozymology

Nanozymology
Author: Xiyun Yan
Publsiher: Springer Nature
Total Pages: 564
Release: 2020-01-30
ISBN 10: 9811514909
ISBN 13: 9789811514906
Language: EN, FR, DE, ES & NL

Nanozymology Book Review:

This book introduces the new concept of “nanozyme”, which refers to nanomaterials with intrinsic enzymatic activity, rather than nanomaterials with biological enzymes incorporated on the surface. The book presents the cutting-edge advances in nanozyme, with emphasis on state-of-the-art applications in many important fields, such as in the biomedical fields and for environmental protection. The nanozyme is a totally new type of artificial enzyme and exhibits huge advantages over natural enzymes, including greater stability, low cost, versatility, simplicity, and suitability for industry. It is of interest to university researchers, R&D engineers, as well as graduate students in nanoscience and technology, and biology wishing to learn the core principles, methods, and the corresponding applications of “nanozyme”.

Sphingolipids in Disease

Sphingolipids in Disease
Author: Erich Gulbins,Irina Petrache
Publsiher: Springer Science & Business Media
Total Pages: 478
Release: 2013-04-06
ISBN 10: 3709115116
ISBN 13: 9783709115114
Language: EN, FR, DE, ES & NL

Sphingolipids in Disease Book Review:

Sphingolipids are lipid components of the plasma membrane of eukaryotic cells with an important function in signaling mechanisms in the cell. This book provides insight into the physiological and pathophysiological role of sphingolipids and in particular its derivative ceramide. The function of Sphingolipids in cell signaling with regard to infectious and lung diseases, cancer, cardiovascular diseases and neuropsychiatric disorders are described and treated in distinct parts. Together with Volume 215 from the same Editors, the collection represents a unique, comprehensive work on Sphingolipids, providing information on both: Sphingolipid basic biology as well as its important function in a (patho)physiological context. The book is written for scientists in pharmacology, biochemistry and cell biology with a focus on biomedical research as well as for clinicians in pharmacology, oncology, cardiology, neurology and infectious disease. ​

Human Drug Targets

Human Drug Targets
Author: Edward D. Zanders
Publsiher: John Wiley & Sons
Total Pages: 456
Release: 2015-11-09
ISBN 10: 111884985X
ISBN 13: 9781118849859
Language: EN, FR, DE, ES & NL

Human Drug Targets Book Review:

The identification of drug targets in a given disease has been central to pharmaceutical research from the latter half of the 20th century right up to the modern genomics era. Human Drug Targets provides an essential guide to one of the most important aspects of drug discovery – the identification of suitable protein and RNA targets prior to the creation of drug development candidates. The first part of the book consists of introductory chapters that provide the background to drug target discovery and highlight the way in which these targets have been organised into online databases. It also includes a user’s guide to the list of entries that forms the bulk of the book. Since this is not designed to be a compendium of drugs, the emphasis will be on the known (or speculated) biological role of the targets and not on the issues associated with pharmaceutical development. The objective is to provide just enough information to be informative and prompt further searches, while keeping the amount of text for each of the many entries to a minimum. Human Drug Targets will prove invaluable to those drug discovery professionals, in both industry and academia, who need to make some sense of the bewildering array of online information sources on current and potential human drug targets. As well as creating order out of a complex target landscape, the book will act as an ideas generator for potentially novel targets that might form the basis of future discovery projects.

Sphingolipids as Signaling and Regulatory Molecules

Sphingolipids as Signaling and Regulatory Molecules
Author: Charles Chalfant,Maurizio Del Poeta
Publsiher: Springer Science & Business Media
Total Pages: 291
Release: 2011-01-12
ISBN 10: 9781441967411
ISBN 13: 1441967419
Language: EN, FR, DE, ES & NL

Sphingolipids as Signaling and Regulatory Molecules Book Review:

This book attempts to analyze the latest discoveries in sphingolipid biology and how the alteration of their metabolism leads to altered signaling events and to the development of pathobiological disorders, such as cancer, cardiovascular diseases, asthma, diabetes, inflammation and infectious diseases.

Advances in Experimental Surgery

Advances in Experimental Surgery
Author: Paulo N. Martins
Publsiher: Anonim
Total Pages: 767
Release: 2017-11
ISBN 10: 9781536127751
ISBN 13: 1536127752
Language: EN, FR, DE, ES & NL

Advances in Experimental Surgery Book Review:

Experimental surgery is an important link for the development in clinical surgery, research and teaching. Experimental surgery was part of the most important surgical discoveries in the past century. Since 1901 nine Nobel Prizes have been awarded to the pioneers had remarkable achievements in the basic or practical surgery. In recent 20 years, experimental surgery has achieved new advances, like laparoscopic and robotic surgery, tissue engineering, and gene therapy which are widely applied in clinic surgery. The present book covers wide experimental surgery in preclinical research models subdivided in two volumes. Volume I introduces surgical basic notions, techniques, and different surgical models involved in basic experimental surgery and review the biomechanical models, ischemia/reperfusion injury models, repair and regeneration models, and organ and tissue transplantation models, respectively. Volume II introduces several specific experimental models such as laparoscopic and bariatric experimental surgical models. The second volume also introduces graft-versus-host disease, and other experimental models. Review the advances and development of recent techniques such as tissue engineering, organ preservation, wound healing and scarring, gene therapy and robotic surgery. The book documents the enormous volume of knowledge we have acquired in the field of experimental surgery. In this book, we have invited experts from the United States, Canada, France, Germany, China, Japan, Korea, UK, Sweden, Netherland, Hungary and Turkey to contribute 36 chapters in the fields of their expertise. These two volumes are the compilation of basic experimental surgery and updated advances of new development in this field that will be invaluable to surgeons, residents, graduate students, surgical researchers, physicians, immunologists, veterinarians and nurses in surgery.

Systems and Synthetic Immunology

Systems and Synthetic Immunology
Author: Shailza Singh
Publsiher: Springer
Total Pages: 269
Release: 2020-04-25
ISBN 10: 9789811533495
ISBN 13: 9811533490
Language: EN, FR, DE, ES & NL

Systems and Synthetic Immunology Book Review:

Systems and Synthetic Immunology focuses on the similarities between biology and engineering at the systems level, which are important for applying engineering theories to biology problems. With the advent of new genomic techniques, there are numerous systematic investigations underway in the scientific world. This volume highlights techniques that can be used to effectively combine two of the most essential biological fields - Systems Biology and Synthetic Immunology. The respective chapters discuss the role of synthetic immunology in biotechnology, production of biomaterials, and their use in vaccine delivery. Further topics include the importance of cytokines; the use of genomic engineering tools in immunotherapy; immunosensors; nanotherapeutics; and bioinformatics tools in biomedical applications. Given its scope, the book offers readers an up-to-date and comprehensive review of this unique and dynamic field of research.

The Ischemic Heart

The Ischemic Heart
Author: Seibu Mochizuki,Nobuakira Takeda,Makoto Nagano,Naranjan S. Dhalla
Publsiher: Springer
Total Pages: 575
Release: 2007-11-23
ISBN 10: 0585398445
ISBN 13: 9780585398440
Language: EN, FR, DE, ES & NL

The Ischemic Heart Book Review:

Over the past three decades, impressive progress in the field of pathogenesis, prevention and therapy of ischemic heart disease has resulted in a marked decline in mortality in the Western World. However, the incidence of this devastating disease is on the rise in developing countries. The Ischemic Heart is based upon a recent symposium in Tokyo on the subject. This volume is organized into two sections: (i) Pathophysiologic Mechanisms of Ischemia-Reperfusion Injury and (ii) Preconditioning and Protection of Ischemia-Reperfusion Injury, and contains up-to-date information concerning the current concepts of ischemia-reperfusion injury, the sequence of events resulting in the loss of contractile dysfunction, and mechanisms of cardioprotection by several drugs as well as the role of ischemic preconditioning in attenuating problems associated with ischemia-reperfusion injury.