Oxidative Stress and Neurodegenerative Disorders

Oxidative Stress and Neurodegenerative Disorders
Author: G. Ali Qureshi,S. Hasan Parvez
Publsiher: Elsevier
Total Pages: 794
Release: 2007-03-22
ISBN 10: 9780080489490
ISBN 13: 0080489494
Language: EN, FR, DE, ES & NL

Oxidative Stress and Neurodegenerative Disorders Book Review:

Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders. * Contains the latest information on the subject of neurodegenerative disorders * Reflects on various factors involved in degeneration and gives suggestions for how to tackle these problems

Oxidative Stress in Cancer AIDS and Neurodegenerative Diseases

Oxidative Stress in Cancer  AIDS  and Neurodegenerative Diseases
Author: Luc Montagnier,Rene Olivier,Catherine Pasquier
Publsiher: CRC Press
Total Pages: 576
Release: 1997-10-06
ISBN 10: 9781420002928
ISBN 13: 1420002929
Language: EN, FR, DE, ES & NL

Oxidative Stress in Cancer AIDS and Neurodegenerative Diseases Book Review:

Based on a conference on Oxidative Stress and Redox Regulation, held at the Pasteur Institute, Paris, this work examines fundamental, chemical, biological and medical studies of free radicals on different targets and the consequences of their reactivity. It covers the chemistry and biochemistry of free radicals, free radicals as second messengers that group the activation of transcription factors and enzymes, the importance of the antioxidant system in cell metabolism regulation, and the role of free radicals and antioxidants in disease management. The editors of this work are three of the most respected pioneers in the field. Dr. Montagnier is credited as the discoverer of HIV.

Oxidative Stress and Age Related Neurodegeneration

Oxidative Stress and Age Related Neurodegeneration
Author: Yuan Luo
Publsiher: CRC Press
Total Pages: 528
Release: 2005-11-21
ISBN 10: 1420026550
ISBN 13: 9781420026559
Language: EN, FR, DE, ES & NL

Oxidative Stress and Age Related Neurodegeneration Book Review:

Despite the progress being made by researchers, Alzheimer’s disease, along with other age-related neurodegenerative disorders, continues to exact a tremendous toll on our society. However, we are beginning to see a relationship that ties degenerative disorders to oxidative stress and lifestyle, suggesting the possibility for prevention and intervention through changes of individual habits, especially with regard to diet. Oxidative Stress and Age-Related Neurodegeneration brings together expert researchers involved with recent developments across a variety of fields. In looking at causation, prevention, and therapy, they offer contributions addressing these questions: What similarities and differences exist between normal aging and disease-related neurodegeneration in terms of susceptibility to and effects of oxidative stress? How can oxidative stress or its effects be attenuated? Do antioxidants prevent or slow the progress of the disease? Is there any role for natural micronutrients in the attenuation of oxidative stress and prevention of age-related neurodegeneration? Some chapters look at the various ways research is getting to the core of neurodegenerative disease, including the use of proteomics, comparisons to related diseases, and examinations at the cellular and molecular levels. Other chapters focus on specific antioxidants and nutrients cited as being impactful, such as those found in Gingko biloba, green tea, blueberries, and grape seed extract. Researchers in academia, industry, and clinical medicine, as well as students and scholars will find use for this timely collection, either as an introduction to our current understanding of neurodegeneration or as a reference for further research. Clinicians will also benefit, as this book explains the basis for many of the latest approaches to prevention and therapy.

Oxidative Stress and Neurodegenerative Disorders

Oxidative Stress and Neurodegenerative Disorders
Author: G. Ali Qureshi,S. Hasan Parvez
Publsiher: Elsevier
Total Pages: 794
Release: 2007-03-22
ISBN 10: 9780080489490
ISBN 13: 0080489494
Language: EN, FR, DE, ES & NL

Oxidative Stress and Neurodegenerative Disorders Book Review:

Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders. * Contains the latest information on the subject of neurodegenerative disorders * Reflects on various factors involved in degeneration and gives suggestions for how to tackle these problems

Alzheimer s Disease Cellular and Molecular Aspects of Amyloid beta

Alzheimer s Disease  Cellular and Molecular Aspects of Amyloid beta
Author: J. Robin Harris,Falk Fahrenholz
Publsiher: Springer Science & Business Media
Total Pages: 409
Release: 2006-11-22
ISBN 10: 0387232265
ISBN 13: 9780387232263
Language: EN, FR, DE, ES & NL

Alzheimer s Disease Cellular and Molecular Aspects of Amyloid beta Book Review:

To understand Alzheimer's disease (AD) is one of the major thrusts of present-day clinical research, strongly supported by more fimdamental cellular, biochemical, immunological and structural studies. It is these latter that receive attention within this book. This compilation of 20 chapters indicates the diversity of work currently in progress and summarizes the current state of knowledge. Experienced authors who are scientifically active in their fields of study have been selected as contributors to this book, in an attempt to present a reasonably complete survey of the field. Inevitably, some exciting topics for one reason or another have not been included, for which we can only apologize. Standardization of terminology is often a problem in science, not least in the Alzheimer field; editorial effort has been made to achieve standardization between the Chapters, but some minor yet acceptable personal / author variation is still present, i. e. P-amyloid/amyloid-P; Ap42/Apl-42/APi. 42! The book commences with a broad survey of the contribution that the range of available microscopical techniques has made to the study of Alzheimer's amyloid plaques and amyloid fibrillogenesis. This chapter also serves as an Introduction to the book, since several of the topics introduced here are expanded upon in later chapters. Also, it is significant to the presence of this chapter that the initial discovery of brain plaques, by Alois Alzheimer, utilized light microscopy, a technique that continues to be extremely valuable in present-day AD research.

A Master Regulator of Oxidative StressThe Transcription Factor Nrf2

A Master Regulator of Oxidative StressThe Transcription Factor Nrf2
Author: Jose Antonio Morales-Gonzalez,Ángel Morales-González,Eduardo Osiris Madrigal-Santillan
Publsiher: BoD – Books on Demand
Total Pages: 210
Release: 2016-12-21
ISBN 10: 953512837X
ISBN 13: 9789535128373
Language: EN, FR, DE, ES & NL

A Master Regulator of Oxidative StressThe Transcription Factor Nrf2 Book Review:

Due to that at present, the majority of diseases are associated with alterations in oxidative stress and inflammatory processes, and in that Nrf-2 is a modulator of these processes; knowing how this transcriptional factor functions and is regulated opens a therapeutic window to diverse diseases. Therefore, the efforts of various investigation groups are centered on finding activators and/or inhibitors of Nrf-2 to prevent or control diverse diseases, for example, cancer, where it would be important to regulate Nrf-2 in order for it to activate apoptosis pathways in cancerogenous cells, or in neurodegenerative diseases where cell death is predominant, it would be important for Nrf-2 to activate antiapoptotic pathways.

Molecular Aspects of Neurodegeneration and Neuroprotection

Molecular Aspects of Neurodegeneration and Neuroprotection
Author: Akhlaq A. Farooqui,Tahira Farooqui
Publsiher: Bentham Science Publishers
Total Pages: 146
Release: 2011-01-26
ISBN 10: 1608050920
ISBN 13: 9781608050925
Language: EN, FR, DE, ES & NL

Molecular Aspects of Neurodegeneration and Neuroprotection Book Review:

"Neurodegenerative diseases are a complex heterogeneous group of diseases associated with site-specific premature and slow death of certain neuronal populations in brain and spinal cord tissues. For example, in Alzheimer disease, neuronal degeneration occu"

Handbook of Research on Critical Examinations of Neurodegenerative Disorders

Handbook of Research on Critical Examinations of Neurodegenerative Disorders
Author: Uddin, Md. Sahab,Amran, Md. Shah
Publsiher: IGI Global
Total Pages: 597
Release: 2018-07-31
ISBN 10: 1522552839
ISBN 13: 9781522552833
Language: EN, FR, DE, ES & NL

Handbook of Research on Critical Examinations of Neurodegenerative Disorders Book Review:

Neurodegeneration is a key feature of several diseases that are referred to as neurodegenerative diseases. The process of neurodegeneration is not well-understood so the diseases that stem from it have, as yet, no cures. As such, studying the effects of these disorders can provide insight into the treatment, prevention, and future opportunities and challenges in this growing field. The Handbook of Research on Critical Examinations of Neurodegenerative Disorders is a critical scholarly resource that provides an extensive explanation of various neurodegenerative disorders based on existing studies to clarify etiology, pathological mechanisms, diagnosis, therapeutic interventions, as well as current status and future opportunities and challenges. Featuring coverage on a broad range of topics such as dementia, mitochondrial dysfunction, and risk factors, this book is geared towards neurobiologists, neuropsychologists, neurophysiologists, neuropathologists, medical professionals, academicians, and researchers seeking research on the complexity of neurodegenerative disorders.

Inflammation and Oxidative Stress in Neurological Disorders

Inflammation and Oxidative Stress in Neurological Disorders
Author: Akhlaq A. Farooqui
Publsiher: Springer Science & Business Media
Total Pages: 355
Release: 2014-01-27
ISBN 10: 3319041118
ISBN 13: 9783319041117
Language: EN, FR, DE, ES & NL

Inflammation and Oxidative Stress in Neurological Disorders Book Review:

Unless new discoveries are made in the prevention or treatment of stroke, Alzheimer's Disease and depression, the number of patients with these diseases is sure to increase dramatically by the year 2050. Thus, developing strategies to retard or delay the onset of stroke, AD and depression these neurological disorders is of critical important. The present monograph will provide current and comprehensive information on the relationship between neuroinflammation and oxidative stress in age-related neurological disorders at the molecular level. The information described in this monograph on lifestyle (diet and exercise), genes and age is intended to facilitate and promote new discoveries for the treatment of age-related neurological disorders.

Free Radicals and Diseases

Free Radicals and Diseases
Author: Rizwan Ahmad
Publsiher: BoD – Books on Demand
Total Pages: 386
Release: 2016-10-26
ISBN 10: 9535127462
ISBN 13: 9789535127468
Language: EN, FR, DE, ES & NL

Free Radicals and Diseases Book Review:

The current volume entitled, "Free Radicals and Diseases" integrates knowledge in free radical-associated diseases from the basic level to the advanced level, and from the bench side to bed side. The chapters in this book provide an extensive overview of the topic, including free radical formations and clinical interventions.

Advances in Dementia Research

Advances in Dementia Research
Author: Kurt A. Jellinger,Reinhold Schmidt,Manfred Windisch
Publsiher: Springer Science & Business Media
Total Pages: 339
Release: 2013-03-07
ISBN 10: 3709167817
ISBN 13: 9783709167816
Language: EN, FR, DE, ES & NL

Advances in Dementia Research Book Review:

Dementia is a major health problem that becomes increasingly common with advancing age. Despite recent progress in neurobiology and molecular genetics, the aetiology and pathogenesis of most dementia disorders are still poorly understood, and early exact diagnosis as a prerequisite of effective treatment needs to be improved. The present volume includes the contributions of renowned experts in the field of neurodegeneration presented at the International Symposium "Ageing and Dementia 1999”, September 24–26, 1999 at Graz. It focusses on genetics, epidemiology, new neuroimaging techniques, and the role of vascular, immunological and other mechanisms including oxidative stress and estrogens in the development of neurodegeneration and dementia. Recent developments in diagnosis and therapy of Alzheimer disease and related disorders are reviewed and future therapeutic approaches are discussed. Thus, this volume provides a timely overview of most recent developments in dementia research and treatment strategies of dementia disorders.

Inflammation Aging and Oxidative Stress

Inflammation  Aging  and Oxidative Stress
Author: Stephen C. Bondy,Arezoo Campbell
Publsiher: Springer
Total Pages: 405
Release: 2016-12-14
ISBN 10: 3319334867
ISBN 13: 9783319334868
Language: EN, FR, DE, ES & NL

Inflammation Aging and Oxidative Stress Book Review:

The book describes the major degenerative processes and pathologies exacerbated by senescence and how they can be alleviated through retardation of cellular aging. Topics discussed include neurodegenerative disease, protein oxidation, cerebrovascular disease, particle-induced inflammation and cardiovascular disease, Alzheimer’s disease, ovarian aging, dietary and endogenous anti-oxidants in management of Parkinson’s disease, and effects of exercise on oxidation and inflammation. The nineteen expertly authored chapters are organized into three sections in order to present a complete picture to the reader: Age Related Cellular Events, Role of Inflammatory and Oxidative Processes in Age-Related Diseases, and Retardation of Cellular Aging. Inflammation, Oxidative Stress and Age-Related Disease draws from a variety of international perspectives and provides a comprehensive overview of the relationship between disease, cell aging, and oxidative stress, as well as potential for preventing or slowing these processes. This installment of Springer’s Oxidative Stress in Applied Basic Research and Clinical Practice is ideal for researchers, clinicians, and advanced graduate students in the fields of cardiology, neuroscience, biogerontolgy, and cell biology.

Oxidative Stress Inflammation and Health

Oxidative Stress  Inflammation  and Health
Author: Young-Joon Surh
Publsiher: CRC Press
Total Pages: 660
Release: 2005-05-24
ISBN 10: 1420028251
ISBN 13: 9781420028256
Language: EN, FR, DE, ES & NL

Oxidative Stress Inflammation and Health Book Review:

Specifically focusing on the redox regulation of cell signaling responsible for oxidative stress and inflammatory tissue damage, this reference provides a comprehensive overview of cutting-edge research on the intracellular events mediating or preventing oxidative stress and pro-inflammatory processes induced by endogenous and xenobiotic factors-analyzing the implications of oxidative stress and inflammatory damage in the pathogenesis of human disorders such as cancer, neurodegenerative disease, and diabetes.

Pathogenesis of Neurodegenerative Disorders

Pathogenesis of Neurodegenerative Disorders
Author: Mark P. Mattson
Publsiher: Springer Science & Business Media
Total Pages: 294
Release: 2001
ISBN 10:
ISBN 13: UOM:39015050824054
Language: EN, FR, DE, ES & NL

Pathogenesis of Neurodegenerative Disorders Book Review:

As the average life expectancy of many populations throughout the world increases, so to does the incidence of such age-related neurodegenerative disorders as Alzheimer's, Parkinson's, and Huntington's diseases. Rapid advances in our understanding of the molecular genetics and environmental factors that either cause or increase risk for age-related neurodegenerative disor ders have been made in the past decade. The ability to evaluate, at the cellular and molecular level, abnormalities in postmortem brain tissue from patients, when taken together with the development of valuable animal and cell-culture models of neurodegenerative disorders has allowed the identification of sequences of events within neurons that result in their demise in specific neurodegenerative disorders. Though the genetic and environmental factors that pro mote neurodegeneration may differ among disorders, shared biochemical cascades that will ultimately lead to the death of neurons have been identified. These cascades involve oxyradical production, aberrant regulation of cellular ion homeostasis and activation of a stereotyped sequence of events involving mitochondrial dysfunction and activa tion of specific proteases. Pathogenesis of Neurodegenerative Disorders provides a timely compilation of articles that encompasses fundamental mechanisms involved in neurodegenerative disorders. In addition, mechanisms that may prevent age-related neurodegenerative disorders are presented. Each chapter is written by an expert in the particular neurodegenerative disorder or mechanism or neuronal death discussed.

Neuroinflammation and Neurodegeneration

Neuroinflammation and Neurodegeneration
Author: Phillip K. Peterson,Michal Toborek
Publsiher: Springer
Total Pages: 600
Release: 2014-07-08
ISBN 10: 149391071X
ISBN 13: 9781493910717
Language: EN, FR, DE, ES & NL

Neuroinflammation and Neurodegeneration Book Review:

State of the art reviews by experts in the fields of neuroscience, immunology, microbiology/infectious diseases and pharmacology addressing the convergence of the immune system (neuroinflammation) and the loss of neurons (neurodegeneration). Many of the diseases that are discussed in the book are of epidemic proportion, e.g., Alzheimer’s disease, Parkinson’s disease, stroke, viral encephalitides and substance abuse. In addition to discussions of the involvement of neuroinflammation and neurodegeneration in these disorders, scientific reviews are presented on the cells and mediators that participate in defense of and damage to the nervous system. With rare exception, no or inadequate treatment exists for the diseases discussed in this book. An underlying premise of the book is that understanding of their shared pathogenic mechanisms will lead to improved therapies. Given the rapid evolution of the field of Neuroimmune Pharmacology, readers will find this book to be the most timely and authoritative reference on the subject of each of its chapters.

Oxidative Stress and Redox Signalling in Parkinson s Disease

Oxidative Stress and Redox Signalling in Parkinson   s Disease
Author: Rodrigo Franco,Jonathan A Doorn,Jean-Christophe Rochet
Publsiher: Royal Society of Chemistry
Total Pages: 520
Release: 2017-07-25
ISBN 10: 1782621881
ISBN 13: 9781782621881
Language: EN, FR, DE, ES & NL

Oxidative Stress and Redox Signalling in Parkinson s Disease Book Review:

Parkinson's Disease is the second most common neurodegenerative disorder affecting millions of people worldwide. In order to find neuroprotective strategies, a clear understanding of the mechanisms involved in the dopaminergic death of cells that progresses the disease is needed. Oxidative stress can be defined as an imbalance between the production of reactive species and the ability to detoxify them and their intermediates or by-products. Oxidative damage to lipids, proteins, and DNA has been detected in autopsies from individuals with Parkinson’s Disease and so links can be made between oxidative stress and Parkinson’s Disease pathogenesis. This book provides a thorough review of the mechanisms by which oxidative stress and redox signalling mediate Parkinson’s Disease. Opening chapters bring readers up to speed on basic knowledge regarding oxidative stress and redox signalling, Parkinson’s Disease, and neurodegeneration before the latest advances in this field are explored in detail. Topics covered in the following chapters include the role of mitochondria, dopamine metabolism, metal homeostasis, inflammation, DNA-damage and thiol-signalling. The role of genetics and gene-environment interactions are also explored before final chapters discuss the identification of potential biomarkers for diagnosis and disease progression and the future of redox/antioxidant based therapeutics. Written by recognized experts in the field, this book will be a valuable source of information for postgraduate students and academics, clinicians, toxicologists and risk assessment groups. Importantly, it presents the current research that might later lead to redox or antioxidant – based therapeutics for Parkinson’s disease.

Neurodegenerative Diseases

Neurodegenerative Diseases
Author: Shamim I. Ahmad
Publsiher: Springer Science & Business Media
Total Pages: 390
Release: 2012-03-12
ISBN 10: 1461406536
ISBN 13: 9781461406532
Language: EN, FR, DE, ES & NL

Neurodegenerative Diseases Book Review:

The editor of this volume, having research interests in the field of ROS production and the damage to cellular systems, has identified a number of enzymes showing ·OH scavenging activities details of which are anticipated to be published in the near future as confirmatory experiments are awaited. It is hoped that the information presented in this book on NDs will stimulate both expert and novice researchers in the field with excellent overviews of the current status of research and pointers to future research goals. Clinicians, nurses as well as families and caregivers should also benefit from the material presented in handling and treating their specialised cases. Also the insights gained should be valuable for further understanding of the diseases at molecular levels and should lead to development of new biomarkers, novel diagnostic tools and more effective therapeutic drugs to treat the clinical problems raised by these devastating diseases.

Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders

Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders
Author: Michael Aschner,Lucio G. Costa
Publsiher: Academic Press
Total Pages: 450
Release: 2015-06-18
ISBN 10: 012800407X
ISBN 13: 9780128004074
Language: EN, FR, DE, ES & NL

Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders Book Review:

Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders presents a state-of-the-art review of the effects of environmental contaminants on the development and degeneration of the human nervous system, brought together by world-leading experts in the field. Part One describes the adverse effects that the environment can have on neurological development, and how these effects may exhibit. Specific contaminants and their possible consequences of exposure are addressed (lead, methylmercury, alcohol), as well as specific disorders and the environmental factors associated with them, such as the effect of diet on attention deficit and hyperactivity disorders. Part Two tackles neurodegenerative disorders, specifically addressing their potential neurotoxic origins, and discussing the increasing interest in the effects that early exposure may have in later life. Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders is an invaluable reference for those professionals working in the fields of toxicology, environmental health and neuroscience. Provides, for the first time, the cutting-edge theory of environmental impacts on both neurodegenerative and neurodevelopmental disorders Written by an international selection of the world’s foremost experts in the field of neurotoxicology Full-colour throughout, providing accurate and illustrative examples of neurotoxic effects in action An invaluable reference for those professionals working in the fields of toxicology, environmental health, and neuroscience

Oxidative Stress and Chronic Degenerative Diseases

Oxidative Stress and Chronic Degenerative Diseases
Author: Jose Antonio Morales-Gonzalez
Publsiher: BoD – Books on Demand
Total Pages: 514
Release: 2013-05-22
ISBN 10: 953511123X
ISBN 13: 9789535111238
Language: EN, FR, DE, ES & NL

Oxidative Stress and Chronic Degenerative Diseases Book Review:

This work responds to the need to find, in a sole document, the affect of oxidative stress at different levels, as well as treatment with antioxidants to revert and diminish the damage. Oxidative Stress and Chronic Degenerative Diseases - a Role for Antioxidants is written for health professionals by researchers at diverse educative institutions (Mexico, Brazil, USA, Spain, Australia, and Slovenia). I would like to underscore that of the 19 chapters, 14 are by Mexican researchers, which demonstrates the commitment of Mexican institutions to academic life and to the prevention and treatment of chronic degenerative diseases.

Novel Prospects in Oxidative and Nitrosative Stress

Novel Prospects in Oxidative and Nitrosative Stress
Author: Pinar Atukeren
Publsiher: BoD – Books on Demand
Total Pages: 156
Release: 2018-05-09
ISBN 10: 1789230861
ISBN 13: 9781789230864
Language: EN, FR, DE, ES & NL

Novel Prospects in Oxidative and Nitrosative Stress Book Review:

Oxidative stress plays a crucial role in the pathophysiology of various diseases when there is a disruption of the intracellular redox balance and the homeostatic balance between cellular oxidants and antioxidants. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) react with molecular targets including proteins, lipids, and nucleic acids contributing to mitochondrial injury and cellular dysfunction. This book intends to provide the readers with an extensive overview of the novel approaches and prospects based on oxidative and nitrosative stress in the pathophysiology of various diseases and in the current treatment strategies with antioxidants.