Oral Delivery of Insulin

Oral Delivery of Insulin
Author: T.A. Sonia,Chandra P. Sharma
Publsiher: Elsevier
Total Pages: 290
Release: 2014-12-11
ISBN 10: 1908818689
ISBN 13: 9781908818683
Language: EN, FR, DE, ES & NL

Oral Delivery of Insulin Book Review:

Diabetes Mellitus, a syndrome of disordered metabolism, characterised by abnormal elevation in blood glucose level, has become a life-threatening condition for many people. Current means of therapy for Diabetes Mellitus do not mimic the normal physiological pattern of insulin release. Oral delivery is the preferred route of administration due to its non-invasive nature. Oral delivery of insulin presents an overview of Diabetes Mellitus, and discusses the strategies and techniques adopted for oral delivery of insulin. This title begins with an introductory chapter on symptoms, complications and therapy for Diabetes Mellitus. Subsequent chapters cover the various routes for administering insulin; the challenges and strategies of oral delivery; experimental techniques in the development of an oral insulin carrier; lipids; inorganic nanoparticles and polymers in oral insulin delivery; and a summary and presentation of future perspectives on oral delivery of insulin. Presents an overview of Diabetes Mellitus Includes a discussion of various strategies and techniques adopted for oral delivery of insulin Presents an update of research in the field

Oral Delivery of Insulin

Oral Delivery of Insulin
Author: T. A. Sonia,Chandra P. Sharma
Publsiher: Woodhead Publishing
Total Pages: 270
Release: 2017-11-13
ISBN 10: 9780081016251
ISBN 13: 0081016255
Language: EN, FR, DE, ES & NL

Oral Delivery of Insulin Book Review:

Diabetes Mellitus, a syndrome of disordered metabolism, characterised by abnormal elevation in blood glucose level, has become a life-threatening condition for many people. Current means of therapy for Diabetes Mellitus do not mimic the normal physiological pattern of insulin release. Oral delivery is the preferred route of administration due to its non-invasive nature. Oral delivery of insulin presents an overview of Diabetes Mellitus, and discusses the strategies and techniques adopted for oral delivery of insulin. This title begins with an introductory chapter on symptoms, complications and therapy for Diabetes Mellitus. Subsequent chapters cover the various routes for administering insulin; the challenges and strategies of oral delivery; experimental techniques in the development of an oral insulin carrier; lipids; inorganic nanoparticles and polymers in oral insulin delivery; and a summary and presentation of future perspectives on oral delivery of insulin. Presents an overview of Diabetes MellitusIncludes a discussion of various strategies and techniques adopted for oral delivery of insulinPresents an update of research in the field

Application of Nanotechnology in Drug Delivery

Application of Nanotechnology in Drug Delivery
Author: Ali Demir Sezer
Publsiher: BoD – Books on Demand
Total Pages: 554
Release: 2014-07-25
ISBN 10: 9535116282
ISBN 13: 9789535116288
Language: EN, FR, DE, ES & NL

Application of Nanotechnology in Drug Delivery Book Review:

This book collects reviews and original articles from eminent experts working in the interdisciplinary arena of nanotechnology use in drug delivery. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of nanotechnology application of drug delivery. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, pulmonary, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.

Development of Nanoparticles for Oral Delivery of Insulin

Development of Nanoparticles for Oral Delivery of Insulin
Author: Sunandini Chopra
Publsiher: Unknown
Total Pages: 177
Release: 2017
ISBN 10:
ISBN 13: OCLC:986242657
Language: EN, FR, DE, ES & NL

Development of Nanoparticles for Oral Delivery of Insulin Book Review:

Parenteral administration remains the mainstay of drug administration for protein therapeutics. However, for diseases that require frequent drug dose over long periods of time, injections can result in patient incompliance and poor treatment outcomes. For such diseases, oral drug delivery is the most non-invasive and patient-compliant method of drug administration. Although oral delivery of many small molecule drugs is routine, oral delivery of protein drugs - e.g. insulin presents several challenges including oral bioavailability of the protein therapeutic because of degradation in the stomach, inactivation and digestion of the therapeutics by the proteolytic enzymes in the luminal cavity, and poor permeability of drugs across the intestinal epithelium. Polymeric nanoparticle (NP) carriers provide new opportunities for controlled delivery of drugs, and have the potential to address challenges associated with effective oral delivery of insulin. NPs can protect the protein therapeutic from degradation in the GI tract as well as allow targeted transport across the epithelial lining. An efficient NP based oral insulin delivery solution that can enable targeted transport of insulin across the GI tract must have (1) high insulin loading, (2) sub-100 nm size, (3) ability to release insulin before opsonization by macrophages and (4) the ability to be surface-functionalized with ligands that facilitate transport across the epithelium. This work presents a detailed study on mechanistic understanding of polymeric insulin NP formation with a focus on the effect of synthesis parameters on insulin loading and NP size. We report how buffer conditions, ionic chelation, and NP preparation methods influence insulin loading in poly (lactic-co-glycolic acid)-b-poly(ethylene glycol) (PLGA-PEG) NPs. We report a 10-fold increase in insulin loading with the use of chelating zinc ions and by the optimization of the pH during nanoprecipitation. Next, we report the development of novel insulin Eudragit-PLGA-PEG blended NPs (Ins-Eud-NPs) with high insulin loading (13.1%) and sub-100 nm size. These NPs enable rapid release of insulin when triggered by a change in pH that occurs when the NPs cross the duodenal epithelium and go from acidic to neutral pH. The NPs are formed by successfully blending Eudragit S100, a commercially available polymer which dissolves at pH greater than 7 with a non-pH responsive polymer, PLGA-PEG. To enable effective transport of these NPs across the epithelial lining, NPs were designed to use the FcRn transport pathway that mediates IgG antibody transport across epithelial barriers. We report the successful chemical conjugation of the Fc fragment on the surface of Ins-Eud- NPs by overcoming the presence of non-ideal conjugation parameters owing to the pH restrictions of the system. This dissertation provides mechanistic insights and helps to understand fundamental concepts about polymeric NP formation and protein encapsulation. The modular NP system developed in this work can be extended to other protein drug delivery systems that are subject to limited drug loading and restricted transport across epithelial barriers.

Subcutaneous and Oral Delivery of Insulin

Subcutaneous and Oral Delivery of Insulin
Author: Zakieh Al Kurdi
Publsiher: Unknown
Total Pages: 329
Release: 2015
ISBN 10:
ISBN 13: OCLC:1064502528
Language: EN, FR, DE, ES & NL

Subcutaneous and Oral Delivery of Insulin Book Review:

Oral Delivery of Insulin by Polymer coated Liposomes

Oral Delivery of Insulin by Polymer coated Liposomes
Author: Majid Tabbakhian,University of Alberta. Faculty of Pharmacy and Pharmaceutical Sciences
Publsiher: Unknown
Total Pages: 328
Release: 1998
ISBN 10:
ISBN 13: OCLC:70485886
Language: EN, FR, DE, ES & NL

Oral Delivery of Insulin by Polymer coated Liposomes Book Review:

Nanoparticle Mediated Oral Delivery of Insulin

Nanoparticle Mediated Oral Delivery of Insulin
Author: Etienne Cabane
Publsiher: Unknown
Total Pages: 324
Release: 2007
ISBN 10:
ISBN 13: OCLC:237099828
Language: EN, FR, DE, ES & NL

Nanoparticle Mediated Oral Delivery of Insulin Book Review:

Chitosan Nanoparticles for the Oral Delivery of Insulin

Chitosan Nanoparticles for the Oral Delivery of Insulin
Author: Zengshuan Ma
Publsiher: Unknown
Total Pages: 442
Release: 2002
ISBN 10:
ISBN 13: OCLC:963033691
Language: EN, FR, DE, ES & NL

Chitosan Nanoparticles for the Oral Delivery of Insulin Book Review:

Oral Delivery of Insulin for Diabetes Therapy

Oral Delivery of Insulin for Diabetes Therapy
Author: Revanth Rayasam
Publsiher: Unknown
Total Pages: 329
Release: 2017
ISBN 10:
ISBN 13: OCLC:1079200389
Language: EN, FR, DE, ES & NL

Oral Delivery of Insulin for Diabetes Therapy Book Review:

Recent Advances in Novel Drug Carrier Systems

Recent Advances in Novel Drug Carrier Systems
Author: Ali Demir Sezer
Publsiher: IntechOpen
Total Pages: 514
Release: 2012-10-31
ISBN 10: 9789535108108
ISBN 13: 9535108107
Language: EN, FR, DE, ES & NL

Recent Advances in Novel Drug Carrier Systems Book Review:

This contribution book collects reviews and original articles from eminent experts working in the interdisciplinary arena of novel drug delivery systems and their uses. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of different drug delivery systems. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, pulmonary, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.

Controlled Drug Delivery Systems

Controlled Drug Delivery Systems
Author: Emmanuel C. Opara
Publsiher: CRC Press
Total Pages: 351
Release: 2020-02-28
ISBN 10: 0429582757
ISBN 13: 9780429582752
Language: EN, FR, DE, ES & NL

Controlled Drug Delivery Systems Book Review:

This book will describe current research on drug delivery systems that encompass four broad categories, namely: routes of delivery, delivery vehicles, payload, and targeting strategies. Where appropriate delivery vehicles and relevant release of specific agents in any of these categories in clinical application will be discussed. All chapters will highlight the translational aspects of the various technologies discussed and will provide insights into the advantages of such delivery systems over current ones in clinical or research use. Each technology reviewed in this book will have significant potential to improve patients' lives by enhancing the therapeutic efficacy of drugs. This book: Discusses the various factors that mitigate effective oral insulin delivery and the current status of research efforts to overcome these barriers along with recent clinical projections Examines the advantages and disadvantages of each drug delivery system Examines the standard method of accomplishing controlled drug release through the incorporation of the drugs within polymeric biomaterials such as capsules and microcapsules as well as other vehicles such as liposomes Discusses various controlled drug delivery systems, including sustained release delivery systems and pulse or delayed release, e.g. to target different regions of the gastrointestinal tract. In view of these wide-ranging technological areas, and the up-to-date discussions of opportunities and challenges associated with these applications, the book should provide readers from technology, materials science, pharmacology and clinical disciplines with very valuable information.

The Potential of Polymeric Nanoparticles for Oral Delivery of Insulin

The Potential of Polymeric Nanoparticles for Oral Delivery of Insulin
Author: Gaurav Sharma
Publsiher: Unknown
Total Pages: 526
Release: 2010
ISBN 10:
ISBN 13: OCLC:768070435
Language: EN, FR, DE, ES & NL

The Potential of Polymeric Nanoparticles for Oral Delivery of Insulin Book Review:

Industrial Applications of Microemulsions

Industrial Applications of Microemulsions
Author: Conxita Solans,Hironobu Kunieda
Publsiher: CRC Press
Total Pages: 424
Release: 1996-11-27
ISBN 10: 9780824797959
ISBN 13: 0824797957
Language: EN, FR, DE, ES & NL

Industrial Applications of Microemulsions Book Review:

"Fills a void in the literature by presenting the basic concepts of microemulsions, essential to understanding their industrial significance, and comprehensive descriptions of the most useful commerical applications. Discusses important issues related to enzymatic reactions and nanoparticle formation. Charts the enormous advances that have occurred in the field over the past decade."

Nanostructures for Oral Medicine

Nanostructures for Oral Medicine
Author: Ecaterina Andronescu,Alexandru Mihai Grumezescu
Publsiher: Elsevier
Total Pages: 1034
Release: 2017-04-11
ISBN 10: 0323477216
ISBN 13: 9780323477215
Language: EN, FR, DE, ES & NL

Nanostructures for Oral Medicine Book Review:

Nanostructures for Oral Medicine presents an up-to-date examination of the applications and effects of nanostructured materials in oral medicine, with each chapter addressing recent developments, specific applications, and uses of nanostructures in the oral administration of therapeutic agents in dentistry. The book also includes coverage of the biocompatibility of nanobiomaterials and their remarkable potential in improving human health and in reducing environmental pollution. Emerging advances, such as Dr. Franklin Tay's concept of a new nanotechnology process of growing extremely small, mineral-rich crystals and guiding them into the demineralized gaps between collagen fibers to prevent the aging and degradation of resin-dentin bonding is also discussed. This work will be of great value to those who work in oral medicine, providing them with a resource to gain a greater understanding of how nanotechnology can help them create more efficient, cost-effective products. In addition, it will be of great interest to those who work in materials science who wish to gain a greater appreciation of how nanostructured materials are applied in this field. Outlines the major uses of nanostructured materials for oral medicine, including the properties of each material discussed and how it should best be applied Explores how nanostructured materials enable the creation of more effective drug delivery systems in oral medicine Discusses how novel uses of nanostructured materials may be applied in oral medicine to create more effective devices

Mucosal Delivery of Biopharmaceuticals

Mucosal Delivery of Biopharmaceuticals
Author: José das Neves,Bruno Sarmento
Publsiher: Springer Science & Business Media
Total Pages: 601
Release: 2014-02-03
ISBN 10: 1461495245
ISBN 13: 9781461495246
Language: EN, FR, DE, ES & NL

Mucosal Delivery of Biopharmaceuticals Book Review:

Biopharmaceutical medicines, the newest class of therapeutics, are quite heterogeneous and include a range of molecules such as proteins, peptides, vaccines and nucleic acids, with use in virtually all therapeutic fields (e.g. cancer and infectious diseases, vaccination, metabolic dysfunctions) and diagnostics. This edited book gives a concise and up-to-date overview of the biological features justifying the use of different human mucosa as delivery routes for biopharmaceuticals, the technological strategies that have been followed so far regarding the optimization of mucosal potentialities as well as the challenges that arise with the advent of new biopharmaceutical drugs and alternative means of administration. Following a brief introduction, the first section addresses general aspects of the biology of mucosal tissues and their unique aspects toward beneficial or deleterious interaction with biopharmaceuticals and their delivery systems. The second part reviews the different delivery strategies that have recently been investigated for different mucosal sites. The third section describes the development and clinical applications of drug delivery systems and products enclosing biopharmaceuticals for mucosal delivery, with a focus on the most successful case studies of recent years. The last section briefly centers on relevant aspects of the regulatory, toxicological and market issues of mucosal delivery of biopharmaceuticals.​ Scientists and researchers in the fields of drug delivery, material science, biomedical science and bioengineering as well as professionals, regulators and policy makers in the pharmaceutical, biotechnology and healthcare industries will find in this book an important compendium of fundamental concepts and practical tools for their daily research and activities.

Oral Controlled Release Formulation Design and Drug Delivery

Oral Controlled Release Formulation Design and Drug Delivery
Author: Hong Wen,Kinam Park
Publsiher: John Wiley & Sons
Total Pages: 376
Release: 2011-01-14
ISBN 10: 9781118060322
ISBN 13: 1118060326
Language: EN, FR, DE, ES & NL

Oral Controlled Release Formulation Design and Drug Delivery Book Review:

This book describes the theories, applications, and challenges for different oral controlled release formulations. This book differs from most in its focus on oral controlled release formulation design and process development. It also covers the related areas like preformulation, biopharmaceutics, in vitro-in vivo correlations (IVIVC), quality by design (QbD), and regulatory issues.

Novel Drug Delivery Systems for Phytoconstituents

Novel Drug Delivery Systems for Phytoconstituents
Author: Madhu Gupta,Durgesh Nandini Chauhan,Vikas Sharma,Nagendra Singh Chauhan
Publsiher: CRC Press
Total Pages: 336
Release: 2019-07-23
ISBN 10: 1351057618
ISBN 13: 9781351057615
Language: EN, FR, DE, ES & NL

Novel Drug Delivery Systems for Phytoconstituents Book Review:

Novel Drug Delivery Systems for Phytoconstituents discusses general principles of drug targeting, construction material and technological concerns of different phytoconstituent in delivery systems. It focuses on the development of novel herbal formulations and summarizes their method of preparation, type of active ingredients, route of administration, biological activity and their applications. It dicusses therapeutic activities of plant derived chemicals, their limitations in clinical applications and novel drug delivery solutions to overcome them to provide better therapeutic effects with controlled and targeted drug delivery. Focus on drug delivery of phytomolecules Act as bridge between natural product scientist and clinical doctors Discusses mechanism of poor bioavailability of herbal molecules Increases awareness towards phytochemical efficacy Summarizes efficient novel delivery systems-based formulations. It extensively covers the applications of novel drug delivery systems including polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid capsules, liposomes, phytosomes, microsphere, transferosomes, and ethosomes. Some chapters are especially focused on anticancer phytodrugs, silymarin, andrographolide, berberine, and curcumin delivery with special emphasis on their application.

Design Development and Evaluation of an Oral Delivery System for Insulin

Design  Development and Evaluation of an Oral Delivery System for Insulin
Author: Mukur Gupta
Publsiher: Unknown
Total Pages: 358
Release: 2004
ISBN 10:
ISBN 13: OCLC:714892215
Language: EN, FR, DE, ES & NL

Design Development and Evaluation of an Oral Delivery System for Insulin Book Review:

The Modification of Insulin to Enhance Oral Delivery Systems

The Modification of Insulin to Enhance Oral Delivery Systems
Author: Melissa Ann Kanzelberger
Publsiher: Unknown
Total Pages: 366
Release: 2009
ISBN 10:
ISBN 13: OCLC:805559589
Language: EN, FR, DE, ES & NL

The Modification of Insulin to Enhance Oral Delivery Systems Book Review:

While a number of PEGylated proteins have been studied for injectable applications and reviewers have used this data to speculate possible oral delivery improvements, a detailed investigation of PEGylated insulin for oral delivery and the development of an optimized pH-sensitive carrier for PEGylated insulin conjugates had yet to be accomplished. In order to proceed with oral delivery study, improvements in yield, with respect to previous PEGylation methods were necessary to enable the completion of high throughput drug delivery studies. Subsequently, a reaction scheme for the covalent attachment of PEG to insulin using nitrophenyl carbonate-PEG was developed. It was demonstrated that this reaction occurred at a 1:1 ratio and was site specific at the B29Lys position. A P(MAA-g-EG) hydrogel carrier was developed to optimize loading and release behavior for PEGylated insulin. It was demonstrated that the density and length of polymer grafts affected both loading and release behavior of PEGylated insulin. The best performing grafted polymers had a 3:1 methacrylic acid: ethylene glycol (MAA:EG) ratio and achieved loading efficiencies from 96% to nearly 100%. With respect to release, polymer particles containing fewer, but longer grafts shown to release faster than polymers with shorter grafts with the same MAA:EG ratio. Finally, the effects of PEGylation on intestinal absorption was investigated using an intestinal epithelial model as well as a rat model. It was demonstrated that PEGylated insulin in the presence of P(MAA-g-EG) microparticles did not significantly alter the tight junctions over unmodified insulin. However, the conjugate permeabilities across the membrane were reduced. The pharmacological availability (PA) was then verified by injecting the insulin conjugates subcutaneously in fasted Sprague-Dawley rats. It was determined that PEG 1000 insulin (1KPI) had a PA roughly equivalent to insulin, while it was reduced by 59% for 2KPI and by 81% for 5KPI. The effectiveness of utilizing PEGylated insulin as an oral drug delivery candidate was evaluated with a closed loop intestinal study, in which PEGylated insulin or insulin in solution was delivered directly to the jejunum. It was shown that 1KPI and insulin performed identically; with a pharmacological availability of 0.56%. 2KPI, however improved the pharmacological availability of insulin by 2.8 times. These results demonstrate that PEGylation holds promise for improving the oral delivery of proteins.

Drug Delivery

Drug Delivery
Author: Yitzhak Rosen,Pablo Gurman,Noel Elman
Publsiher: CRC Press
Total Pages: 602
Release: 2017-09-19
ISBN 10: 1351643851
ISBN 13: 9781351643856
Language: EN, FR, DE, ES & NL

Drug Delivery Book Review:

Integrating the clinical and engineering aspects of drug delivery, this book offers a much needed comprehensive overview and patient-oriented approach for enhanced drug delivery optimization and advancement. Starting with an introduction to the subject and pharmacokinetics, it explores advances for such topics as oral, gastroretentive, intravitreal, and intrathecal drug delivery, as well as insulin delivery, gene delivery, and biomaterials-based delivery systems. It also describes drug delivery in cancer, cardiac, infectious diseases, airway diseases, and obstetrics and gynecology applications. Examining special clinical states requiring innovative drug delivery modifications, such as hypercoagulability often seen in pregnancy, cancer, and autoimmune diseases, the book also discusses methods for improved drug delivery in clinical settings using clinical end points, clinical trials, simulations, and other venues. It also describes the latest drug delivery advances involving nanomaterials, NEMS and MEMS devices, hydrogels, microencapsulation, lipids, stem cells, patches, and ultrasound. The book is rounded out by a chapter on the FDA regulatory and bioethical challenges involved in advancing drug delivery.