# ODE/PDE Analysis of Antibiotic/Antimicrobial Resistance

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## ODE PDE Analysis of Antibiotic Antimicrobial Resistance

Author | : William E. Schiesser |

Publsiher | : Academic Press |

Total Pages | : 122 |

Release | : 2020-08-24 |

ISBN 10 | : 0128242507 |

ISBN 13 | : 9780128242506 |

Language | : EN, FR, DE, ES & NL |

**ODE PDE Analysis of Antibiotic Antimicrobial Resistance Book Review:**

Mathematical models for antibiotic/antimicrobial resistance based on ordinary and partial differential equations (ODE/PDEs) are presented in this book, starting with a basic ODE model in Chapter 1, and concluding with a detailed PDE model in Chapters 4 and 5 that gives the spatiotemporal distribution of four dependent variable components: (1) susceptible bacteria population density, (2) resistant bacteria population density, (3) plasmid number, and (4) antibiotic concentration. The computer-based implementation of the example models is presented through routines coded (programmed) in R, a quality, open-source scientific computing system that is readily available from the Internet. Formal mathematics is minimized, e.g., no theorems and proofs. Rather, the presentation is through detailed examples that the reader/researcher/analyst can execute on modest computers. The PDE analysis is based on the method of lines (MOL), an established general algorithm for PDEs, implemented with finite differences. The routines are available from a download link so that the example models can be executed without having to first study numerical methods and computer coding. The routines can then be applied to variations and extensions of the antibiotic/antimicrobial models, such as changes in the ODE/PDE parameters (constants) and the form of the model equations. Includes PDE routines based on the method of lines (MOL) for computer-based implementation of PDE models Offers transportable computer source codes for readers in R, with line-by-line code descriptions as it relates to the mathematical model and algorithms Authored by a leading researcher and educator in PDE models

## Systems Medicine

Author | : Anonim |

Publsiher | : Academic Press |

Total Pages | : 1589 |

Release | : 2020-08-24 |

ISBN 10 | : 0128160780 |

ISBN 13 | : 9780128160787 |

Language | : EN, FR, DE, ES & NL |

**Systems Medicine Book Review:**

Technological advances in generated molecular and cell biological data are transforming biomedical research. Sequencing, multi-omics and imaging technologies are likely to have deep impact on the future of medical practice. In parallel to technological developments, methodologies to gather, integrate, visualize and analyze heterogeneous and large-scale data sets are needed to develop new approaches for diagnosis, prognosis and therapy. Systems Medicine: Integrative, Qualitative and Computational Approaches is an innovative, interdisciplinary and integrative approach that extends the concept of systems biology and the unprecedented insights that computational methods and mathematical modeling offer of the interactions and network behavior of complex biological systems, to novel clinically relevant applications for the design of more successful prognostic, diagnostic and therapeutic approaches. This 3 volume work features 132 entries from renowned experts in the fields and covers the tools, methods, algorithms and data analysis workflows used for integrating and analyzing multi-dimensional data routinely generated in clinical settings with the aim of providing medical practitioners with robust clinical decision support systems. Importantly the work delves into the applications of systems medicine in areas such as tumor systems biology, metabolic and cardiovascular diseases as well as immunology and infectious diseases amongst others. This is a fundamental resource for biomedical students and researchers as well as medical practitioners who need to need to adopt advances in computational tools and methods into the clinical practice. Encyclopedic coverage: ‘one-stop’ resource for access to information written by world-leading scholars in the field of Systems Biology and Systems Medicine, with easy cross-referencing of related articles to promote understanding and further research Authoritative: the whole work is authored and edited by recognized experts in the field, with a range of different expertise, ensuring a high quality standard Digitally innovative: Hyperlinked references and further readings, cross-references and diagrams/images will allow readers to easily navigate a wealth of information

## Comprehensive Medicinal Chemistry III

Author | : Anonim |

Publsiher | : Elsevier |

Total Pages | : 4536 |

Release | : 2017-06-03 |

ISBN 10 | : 0128032014 |

ISBN 13 | : 9780128032015 |

Language | : EN, FR, DE, ES & NL |

**Comprehensive Medicinal Chemistry III Book Review:**

Comprehensive Medicinal Chemistry III provides a contemporary and forward-looking critical analysis and summary of recent developments, emerging trends, and recently identified new areas where medicinal chemistry is having an impact. The discipline of medicinal chemistry continues to evolve as it adapts to new opportunities and strives to solve new challenges. These include drug targeting, biomolecular therapeutics, development of chemical biology tools, data collection and analysis, in silico models as predictors for biological properties, identification and validation of new targets, approaches to quantify target engagement, new methods for synthesis of drug candidates such as green chemistry, development of novel scaffolds for drug discovery, and the role of regulatory agencies in drug discovery. Reviews the strategies, technologies, principles, and applications of modern medicinal chemistry Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs

## Understanding the Dynamics of Biological Systems

Author | : Werner Dubitzky,Jennifer Southgate,Hendrik Fuß |

Publsiher | : Springer Science & Business Media |

Total Pages | : 238 |

Release | : 2011-01-07 |

ISBN 10 | : 9781441979643 |

ISBN 13 | : 1441979646 |

Language | : EN, FR, DE, ES & NL |

**Understanding the Dynamics of Biological Systems Book Review:**

This book is intended as a communication platform to bridge the cultural, conceptual, and technological gap among the key systems biology disciplines of biology, mathematics, and information technology. To support this goal, contributors were asked to adopts an approach that appeals to audiences from different backgrounds.

## Microbial Community Modeling Prediction of Microbial Interactions and Community Dynamics

Author | : Hyun-Seob Song |

Publsiher | : MDPI |

Total Pages | : 295 |

Release | : 2018-07-04 |

ISBN 10 | : 3038429759 |

ISBN 13 | : 9783038429753 |

Language | : EN, FR, DE, ES & NL |

**Microbial Community Modeling Prediction of Microbial Interactions and Community Dynamics Book Review:**

This book is a printed edition of the Special Issue "Microbial Community Modeling: Prediction of Microbial Interactions and Community Dynamics" that was published in Processes

## An Introduction to Undergraduate Research in Computational and Mathematical Biology

Author | : Hannah Callender Highlander,Alex Capaldi,Carrie Diaz Eaton |

Publsiher | : Springer Nature |

Total Pages | : 469 |

Release | : 2020-02-17 |

ISBN 10 | : 303033645X |

ISBN 13 | : 9783030336455 |

Language | : EN, FR, DE, ES & NL |

**An Introduction to Undergraduate Research in Computational and Mathematical Biology Book Review:**

Speaking directly to the growing importance of research experience in undergraduate mathematics programs, this volume offers suggestions for undergraduate-appropriate research projects in mathematical and computational biology for students and their faculty mentors. The aim of each chapter is twofold: for faculty, to alleviate the challenges of identifying accessible topics and advising students through the research process; for students, to provide sufficient background, additional references, and context to excite students in these areas and to enable them to successfully undertake these problems in their research. Some of the topics discussed include: • Oscillatory behaviors present in real-world applications, from seasonal outbreaks of childhood diseases to action potentials in neurons • Simulating bacterial growth, competition, and resistance with agent-based models and laboratory experiments • Network structure and the dynamics of biological systems • Using neural networks to identify bird species from birdsong samples • Modeling fluid flow induced by the motion of pulmonary cilia Aimed at undergraduate mathematics faculty and advanced undergraduate students, this unique guide will be a valuable resource for generating fruitful research collaborations between students and faculty.

## Mechanisms of antibiotic resistance

Author | : Jun Lin,Kunihiko Nishino,Marilyn C. Roberts,Marcelo Tolmasky,Rustam I. Aminov,Lixin Zhang |

Publsiher | : Frontiers Media SA |

Total Pages | : 329 |

Release | : 2015-06-01 |

ISBN 10 | : 2889195260 |

ISBN 13 | : 9782889195268 |

Language | : EN, FR, DE, ES & NL |

**Mechanisms of antibiotic resistance Book Review:**

Antibiotics represent one of the most successful forms of therapy in medicine. But the efficiency of antibiotics is compromised by the growing number of antibiotic-resistant pathogens. Antibiotic resistance, which is implicated in elevated morbidity and mortality rates as well as in the increased treatment costs, is considered to be one of the major global public health threats (www.who.int/drugresistance/en/) and the magnitude of the problem recently prompted a number of international and national bodies to take actions to protect the public (http://ec.europa.eu/dgs/health_consumer/docs/road-map-amr_en.pdf: http://www.who.int/drugresistance/amr_global_action_plan/en/; http://www.whitehouse.gov/sites/default/files/docs/carb_national_strategy.pdf). Understanding the mechanisms by which bacteria successfully defend themselves against the antibiotic assault represent the main theme of this eBook published as a Research Topic in Frontiers in Microbiology, section of Antimicrobials, Resistance, and Chemotherapy. The articles in the eBook update the reader on various aspects and mechanisms of antibiotic resistance. A better understanding of these mechanisms should facilitate the development of means to potentiate the efficacy and increase the lifespan of antibiotics while minimizing the emergence of antibiotic resistance among pathogens.

## The New Generation of Quinolones

Author | : Siporin |

Publsiher | : CRC Press |

Total Pages | : 368 |

Release | : 1990-08-28 |

ISBN 10 | : 9780824782245 |

ISBN 13 | : 0824782240 |

Language | : EN, FR, DE, ES & NL |

**The New Generation of Quinolones Book Review:**

Surveys the newest members of a family of antimicrobial drugs increasingly being used to treat infections of the urinary tract, lungs, skin, bones, and diarrheal diseases. The drugs have been developed only since the 1960s, and still pose many questions about resistance and toxic and developmental s

## Applications of Dynamical Systems in Biology and Medicine

Author | : Trachette Jackson,Ami Radunskaya |

Publsiher | : Springer |

Total Pages | : 233 |

Release | : 2015-07-06 |

ISBN 10 | : 1493927825 |

ISBN 13 | : 9781493927821 |

Language | : EN, FR, DE, ES & NL |

**Applications of Dynamical Systems in Biology and Medicine Book Review:**

This volume highlights problems from a range of biological and medical applications that can be interpreted as questions about system behavior or control. Topics include drug resistance in cancer and malaria, biological fluid dynamics, auto-regulation in the kidney, anti-coagulation therapy, evolutionary diversification and photo-transduction. Mathematical techniques used to describe and investigate these biological and medical problems include ordinary, partial and stochastic differentiation equations, hybrid discrete-continuous approaches, as well as 2 and 3D numerical simulation.

## Differential Equations

Author | : Bruce P. Conrad |

Publsiher | : Anonim |

Total Pages | : 462 |

Release | : 2003 |

ISBN 10 | : |

ISBN 13 | : UCSC:32106011431795 |

Language | : EN, FR, DE, ES & NL |

**Differential Equations Book Review:**

Written for beginners, this well organized introduction promotes a solid understanding of differential equations that is flexible enough to meet the needs of many different disciplines. With less emphasis on formal calculation than found in other books all the basic methods are covered—first order equations, separation, exact form, and linear equations—as well as higher order cases, linear equation with constant and variable coefficients, Laplace transform methods, and boundary value problems. The book's systems focus induces an intuitive understanding of the concept of a solution of an initial value problem in order to resolve potential confusion about what is being approximated when a numerical method is used. The author outlines first order equations including linear and nonlinear equations and systems of differential equations, as well as linear differential equations including the Laplace transform, and variable coefficients, nonlinear differential equations, and boundary problems and PDEs. For those looking for a solid introduction to differential equations.

## Intestinal health

Author | : Theo Niewold |

Publsiher | : Wageningen Academic Publishers |

Total Pages | : 276 |

Release | : 2014-11-27 |

ISBN 10 | : 9086867928 |

ISBN 13 | : 9789086867929 |

Language | : EN, FR, DE, ES & NL |

**Intestinal health Book Review:**

Livestock production is changing worldwide. Amongst the changes are those instigated by legislation such as restrictions on antibiotics and antibiotic growth promoters, well fare regulations, etc., all forcing livestock producers to adapt to new husbandry, management, nutrition and healthcare techniques. Food safety is an explosive political issue. The expectations and demands of the informed consumer have altered perceptions of risk and brought food safety to the very front and centre of politics. The gastrointestinal tract is essential in the maintenance of health, wellbeing and production in livestock. The above changes impact feed formulation. The industry looks for alternatives to maintain intestinal health and maximise animal performance, whilst complying with increasingly stringent legislation. This requires a good understanding of the physiological processes involved. In this book, the current knowledge in the major monogastric production species (pigs and chicken) is reviewed by renowned experts in the field. It describes infectious and non-infectious challenges as well as the complex interaction between innate, cellular and humoral immunity and performance. The problems that this complexity poses concerning the identification of important factors for intestinal health are discussed. 'Intestinal health' also reviews promising new approaches such as the use and development of validated biomarkers, and the application of omics techniques and systems biology.

## Dictionary of Pharmaceutical Medicine

Author | : Gerhard Nahler |

Publsiher | : Springer Science & Business Media |

Total Pages | : 179 |

Release | : 2013-06-29 |

ISBN 10 | : 3709140161 |

ISBN 13 | : 9783709140161 |

Language | : EN, FR, DE, ES & NL |

**Dictionary of Pharmaceutical Medicine Book Review:**

This dictionary is aimed primarily at the beginners entering the new discipline of Pharmaceutical Medicine, an area comprising aspects of toxicology, pharmacology, pharmaceutics, epidemiology, statistics, drug regulatory and legal affairs, medicine and marketing. But also more experienced colleagues in departments engaged in clinical development as well as researchers and marketing experts in the pharmaceutical industry will find concise and up-to-date information. The book is completed by a list of a about 1000 abbreviations encountered in pharmaceutical medicine and a compilation of important addresses of national and international health authorities.

## Bibliography of Agriculture

Author | : Anonim |

Publsiher | : Anonim |

Total Pages | : 329 |

Release | : 1972 |

ISBN 10 | : |

ISBN 13 | : PSU:000057552637 |

Language | : EN, FR, DE, ES & NL |

**Bibliography of Agriculture Book Review:**

## Mathematical Modeling in Systems Biology

Author | : Brian P. Ingalls |

Publsiher | : MIT Press |

Total Pages | : 408 |

Release | : 2013-07-05 |

ISBN 10 | : 0262018888 |

ISBN 13 | : 9780262018883 |

Language | : EN, FR, DE, ES & NL |

**Mathematical Modeling in Systems Biology Book Review:**

An introduction to the mathematical concepts and techniques needed for the construction and analysis of models in molecular systems biology. Systems techniques are integral to current research in molecular cell biology, and system-level investigations are often accompanied by mathematical models. These models serve as working hypotheses: they help us to understand and predict the behavior of complex systems. This book offers an introduction to mathematical concepts and techniques needed for the construction and interpretation of models in molecular systems biology. It is accessible to upper-level undergraduate or graduate students in life science or engineering who have some familiarity with calculus, and will be a useful reference for researchers at all levels. The first four chapters cover the basics of mathematical modeling in molecular systems biology. The last four chapters address specific biological domains, treating modeling of metabolic networks, of signal transduction pathways, of gene regulatory networks, and of electrophysiology and neuronal action potentials. Chapters 3–8 end with optional sections that address more specialized modeling topics. Exercises, solvable with pen-and-paper calculations, appear throughout the text to encourage interaction with the mathematical techniques. More involved end-of-chapter problem sets require computational software. Appendixes provide a review of basic concepts of molecular biology, additional mathematical background material, and tutorials for two computational software packages (XPPAUT and MATLAB) that can be used for model simulation and analysis.

## Dermal Exposure

Author | : World Health Organization |

Publsiher | : Anonim |

Total Pages | : 500 |

Release | : 2015-04-20 |

ISBN 10 | : 9789241572422 |

ISBN 13 | : 9241572426 |

Language | : EN, FR, DE, ES & NL |

**Dermal Exposure Book Review:**

This Environmental Health Criteria (EHC) series publication addresses dermal exposure to chemicals. It describes sources and pathways of dermal exposure, models and tools to estimate dermal exposure and methods for dermal exposure prevention and reduction. Furthermore, the EHC introduces skin diseases associated with dermal exposure. This EHC aims to provide information to national regulatory authorities to assist in conducting health risk assessments and managing the risk involving dermal exposure to chemicals.

## Virus Dynamics Mathematical Principles of Immunology and Virology

Author | : Martin Nowak,Robert M. May |

Publsiher | : Oxford University Press, UK |

Total Pages | : 250 |

Release | : 2000-11-23 |

ISBN 10 | : 0191588512 |

ISBN 13 | : 9780191588518 |

Language | : EN, FR, DE, ES & NL |

**Virus Dynamics Mathematical Principles of Immunology and Virology Book Review:**

This groundbreaking book describes the emerging field of theoretical immunology, in particular the use of mathematical models to describe the spread of infectious diseases within patients. It reveals fascinating insights into the dynamics of viral and other infections, and the interactions between infectious agents and immune responses. Structured around the examples of HIV/AIDS and hepatitis B, Nowak and May show how mathematical models can help researchers to understand the detailed dynamics of infection and the effects of antiviral therapy. Models are developed to describe the dynamics of drug resistance, immune responses, viral evolution and mutation, and to optimise the design of therapy and vaccines. - ;We know, down to the tiniest details, the molecular structure of the human immunodeficiency virus (HIV). Yet despite this tremendous accomplishment, and despite other remarkable advances in our understanding of individual viruses and cells of the immune system, we still have no agreed understanding of the ultimate course and variability of the pathogenesis of AIDS. Gaps in our understanding like these impede our efforts towards developing effective therapies and preventive vaccines. Martin Nowak and Robert M May describe the emerging field of theoretical immunology in this accessible and well- written text. Using mathematical modelling techniques, the authors set out their ideas about how populations of viruses and populations of immune system cells may interact in various circumstances, and how infectious diseases spread within patients. They explain how this approach to understanding infectious diseases can reveal insights into the dynamics of viral and other infections, and the interactions between infectious agents and immune responses. The book is structured around the examples of HIV/AIDS and Hepatitis B virus, although the approaches described will be more widely applicable. The authors use mathematical tools to uncover the detailed dynamics of the infection and the effects of antiviral therapy. Models are developed to describe the emergence of drug resistance, and the dynamics of immune responses, viral evolution, and mutation. The practical implications of this work for optimisation of the design of therapy and vaccines are discussed. The book concludes with a glance towards the future of this fascinating, and potentially highly useful, field of study. - ;... an excellent introduction to a field that has the potential to advance substantially our understanding of the complex interplay between virus and host - Nature

## Mathematical Models in Biology

Author | : Leah Edelstein-Keshet |

Publsiher | : SIAM |

Total Pages | : 586 |

Release | : 1988 |

ISBN 10 | : 9780898719147 |

ISBN 13 | : 0898719143 |

Language | : EN, FR, DE, ES & NL |

**Mathematical Models in Biology Book Review:**

Mathematical Models in Biology is an introductory book for readers interested in biological applications of mathematics and modeling in biology. A favorite in the mathematical biology community, it shows how relatively simple mathematics can be applied to a variety of models to draw interesting conclusions. Connections are made between diverse biological examples linked by common mathematical themes. A variety of discrete and continuous ordinary and partial differential equation models are explored. Although great advances have taken place in many of the topics covered, the simple lessons contained in this book are still important and informative. Audience: the book does not assume too much background knowledge--essentially some calculus and high-school algebra. It was originally written with third- and fourth-year undergraduate mathematical-biology majors in mind; however, it was picked up by beginning graduate students as well as researchers in math (and some in biology) who wanted to learn about this field.

## Ordinary and Partial Differential Equation Routines in C C Fortran Java Maple and MATLAB

Author | : H.J. Lee,W.E. Schiesser |

Publsiher | : CRC Press |

Total Pages | : 528 |

Release | : 2003-11-24 |

ISBN 10 | : 9780203010518 |

ISBN 13 | : 0203010515 |

Language | : EN, FR, DE, ES & NL |

**Ordinary and Partial Differential Equation Routines in C C Fortran Java Maple and MATLAB Book Review:**

This book provides a set of ODE/PDE integration routines in the six most widely used computer languages, enabling scientists and engineers to apply ODE/PDE analysis toward solving complex problems. This text concisely reviews integration algorithms, then analyzes the widely used Runge-Kutta method. It first presents a complete code before discussin

## Computational Approaches in Biomedical Nano Engineering

Author | : Ayesha Sohail,Zhiwu Li |

Publsiher | : John Wiley & Sons |

Total Pages | : 296 |

Release | : 2019-01-14 |

ISBN 10 | : 3527344713 |

ISBN 13 | : 9783527344710 |

Language | : EN, FR, DE, ES & NL |

**Computational Approaches in Biomedical Nano Engineering Book Review:**

This book comprehensively and systematically treats modern understanding of the Nano-Bio-Technology and its therapeutic applications. The contents range from the nanomedicine, imaging, targeted therapeutic applications, experimental results along with modelling approaches. It will provide the readers with fundamentals on computational and modelling aspects of advanced nano-materials and nano-technology specifically in the field of biomedicine, and also provide the readers with inspirations for new development of diagnostic imaging and targeted therapeutic applications.

## Mathematical and Statistical Modeling for Emerging and Re emerging Infectious Diseases

Author | : Gerardo Chowell,James M. Hyman |

Publsiher | : Springer |

Total Pages | : 356 |

Release | : 2016-07-27 |

ISBN 10 | : 331940413X |

ISBN 13 | : 9783319404134 |

Language | : EN, FR, DE, ES & NL |

**Mathematical and Statistical Modeling for Emerging and Re emerging Infectious Diseases Book Review:**

The contributions by epidemic modeling experts describe how mathematical models and statistical forecasting are created to capture the most important aspects of an emerging epidemic.Readers will discover a broad range of approaches to address questions, such as Can we control Ebola via ring vaccination strategies? How quickly should we detect Ebola cases to ensure epidemic control? What is the likelihood that an Ebola epidemic in West Africa leads to secondary outbreaks in other parts of the world? When does it matter to incorporate the role of disease-induced mortality on epidemic models? What is the role of behavior changes on Ebola dynamics? How can we better understand the control of cholera or Ebola using optimal control theory? How should a population be structured in order to mimic the transmission dynamics of diseases such as chlamydia, Ebola, or cholera? How can we objectively determine the end of an epidemic? How can we use metapopulation models to understand the role of movement restrictions and migration patterns on the spread of infectious diseases? How can we capture the impact of household transmission using compartmental epidemic models? How could behavior-dependent vaccination affect the dynamical outcomes of epidemic models? The derivation and analysis of the mathematical models addressing these questions provides a wide-ranging overview of the new approaches being created to better forecast and mitigate emerging epidemics. This book will be of interest to researchers in the field of mathematical epidemiology, as well as public health workers.