Ocular Transporters and Receptors
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Ocular Transporters and Receptors
Author | : Ashim K Mitra |
Publsiher | : Elsevier |
Total Pages | : 276 |
Release | : 2013-10-31 |
ISBN 10 | : 190881831X |
ISBN 13 | : 9781908818317 |
Language | : EN, FR, DE, ES & NL |
Ocular transporters and receptors contains detailed descriptions of major transporters and receptors expressed in the eye, with special emphasis on their role in drug delivery. The complex anatomy and the existence of multiple barriers in the eye pose a considerable challenge to successful drug delivery to the eye. Hence ocular transporters and receptors are important targets for drug delivery. A significant advancement has been made in the field of ocular transport research and their role in drug delivery. In this book the cutting edge research being carried out in this field is compiled and summarized. The book focuses on key areas, including the anatomy and physiology of the eye, biology of ocular transporters and receptors, techniques in characterization of transporters and receptors, transporters and receptors in the anterior and posterior segment in the eye, the role of ocular transporters and receptors in drug delivery, and transporter-metabolism interplay in the eye. Highly focused on ocular transporters Most up-to-date research compilation Detailed description of role of transporters and receptors in ocular drug discovery and delivery
Ocular Transporters in Ophthalmic Diseases and Drug Delivery
Author | : Joyce Tombran-Tink,Colin J. Barnstable |
Publsiher | : Springer Science & Business Media |
Total Pages | : 467 |
Release | : 2008-04-09 |
ISBN 10 | : 9781597453752 |
ISBN 13 | : 1597453757 |
Language | : EN, FR, DE, ES & NL |
In this exceptionally important new work, a panel of distinguished authors discusses all the latest developments in the study of ocular transporters. Focusing on the molecular characteristics, localization, and substrate specificities in various compartments of the eye, this volume discusses how transporters regulate the clarity of the cornea and lens, the movements of fluids across the ciliary epithelium and nutrients across the retinal pigment epithelium.
Biomedical Index to PHS supported Research
Author | : Anonim |
Publsiher | : Unknown |
Total Pages | : 329 |
Release | : 1990 |
ISBN 10 | : |
ISBN 13 | : STANFORD:36105119624620 |
Language | : EN, FR, DE, ES & NL |
Research Awards Index
Author | : Anonim |
Publsiher | : Unknown |
Total Pages | : 329 |
Release | : 1984 |
ISBN 10 | : |
ISBN 13 | : STANFORD:36105119624752 |
Language | : EN, FR, DE, ES & NL |
Cell Biology of the Eye
Author | : David Mcdevitt |
Publsiher | : Elsevier |
Total Pages | : 584 |
Release | : 2012-12-02 |
ISBN 10 | : 0323145213 |
ISBN 13 | : 9780323145213 |
Language | : EN, FR, DE, ES & NL |
Cell Biology of the Eye discusses the eye tissues and its role in the investigations on active transport, growth factors, receptors, and differentiation. The book is comprised of articles which discuss corneal proteoglycans; transport of ions and metabolites across the corneal endothelium; the ontogeny and localization of the crystallins in eye lens development and regeneration; the biological-physical basis of lens transparency; the chromatic organization of the retina; and the dopamine neurons in the retina. This treatise will serve as a valuable reference text for graduate and professional students, teachers, researchers, clinicians, and to all in the vision field.
Mechanisms of Water and Solute Transport at the Ocular Surface
Author | : Marc Harris Levin |
Publsiher | : Unknown |
Total Pages | : 275 |
Release | : 2006 |
ISBN 10 | : |
ISBN 13 | : UCAL:X85575 |
Language | : EN, FR, DE, ES & NL |
Actions of and interactions among AQPs, CFTR, and ENaC are also of central importance to airway surface liquid (ASL) function and dysfunction, and have been considered with regard to both the etiology and possible treatment of cystic fibrosis (CF) lung disease. Recent data indicated clinical benefit of nebulized hypertonic saline in CF. The proposed mechanism of increased ASL volume relies on purported inhibition of lung AQPs by the ENaC inhibitor amiloride. Sensitive fluorescence methods indicated that amiloride does not inhibit AQP-mediated airway water permeability, indicating the need to identify alternate mechanisms for clinical benefit of hypertonic saline.
Pharmacologic Therapy of Ocular Disease
Author | : Scott M. Whitcup,Dimitri T. Azar |
Publsiher | : Springer |
Total Pages | : 389 |
Release | : 2017-06-22 |
ISBN 10 | : 3319582909 |
ISBN 13 | : 9783319582900 |
Language | : EN, FR, DE, ES & NL |
There have been major advancements in the pharmacologic treatment of eye diseases over the past decade. With newly discovered disease targets and novel approaches to deliver therapeutic compounds to the eye, patients are seeing improved outcomes. Not only are there better treatments for diseases where treatments existed, we now have effective therapy for previously untreatable and blinding eye disorders. This volume will cover the pharmacologic treatment of eye diseases from the front of the eye including eyelids, conjunctiva and cornea all the way back to the retina and optic nerve. The first section of the volume reviews general principles of ocular pharmacology, pharmacokinetics, pharmaceutical sciences, and drug delivery. In addition, the volume provides an up to date guide to the pharmacologic approach to the key eye diseases that threaten sight or ocular function.
Drug Delivery
Author | : Ashim K. Mitra,Chairman and Curator's Professor Pharmaceutical Sciences University of Missouri Kansas City Missouri Ashim K Mitra,Deep Kwatra,Aswani Dutt Vadlapudi |
Publsiher | : Jones & Bartlett Publishers |
Total Pages | : 400 |
Release | : 2014-08-18 |
ISBN 10 | : 1449674267 |
ISBN 13 | : 9781449674267 |
Language | : EN, FR, DE, ES & NL |
Drug Delivery is the latest and most up-to-date text on drug delivery and offers an excellent working foundation for students and clinicians in health professions and graduate students including nursing, pharmacy, medicine, dentistry, as well as researchers and scientists. Presenting this complex content in an organized and concise format, Drug Delivery allows students to gain a strong understanding of the key concepts of drug delivery.This text focuses on the basic concepts of drug delivery while thoroughly examining various topics such as: CNS delivery Gene delivery Ocular delivery World-wide research on drug delivery Recent advances in drug deliveryA significant advancement has been made in the field of drug delivery. This text provides a detailed overview of drug delivery systems, routes of drug administration and development of various formulations. The cutting edge research being carried out in this field will be compiled and a focus on worldwide research on drug delivery and targeting at the molecular, cellular, and organ levels will also be summarized.Each new print copy includes access to the Navigate Companion Website including: Chapter Quizzes, Interactive Glossary, Crossword Puzzles , Interactive Flashcards, and Matching Exercises
Current Eye Research
Author | : Anonim |
Publsiher | : Unknown |
Total Pages | : 329 |
Release | : 1987 |
ISBN 10 | : |
ISBN 13 | : UCLA:31158012480058 |
Language | : EN, FR, DE, ES & NL |
Ophthalmic Drug Delivery Systems
Author | : Ashim K. Mitra |
Publsiher | : CRC Press |
Total Pages | : 847 |
Release | : 2019-12 |
ISBN 10 | : 9780367446765 |
ISBN 13 | : 0367446766 |
Language | : EN, FR, DE, ES & NL |
The second edition of this text assembles significant ophthalmic advances and encompasses breakthroughs in gene therapy, ocular microdialysis, vitreous drug disposition modelling, and receptor/transporter targeted drug delivery.
Jules Stein Eye Institute
Author | : Jules Stein Eye Institute |
Publsiher | : Unknown |
Total Pages | : 329 |
Release | : 1996 |
ISBN 10 | : |
ISBN 13 | : UCLA:L0077332260 |
Language | : EN, FR, DE, ES & NL |
Pharmacology of Ocular Therapeutics
Author | : Thirumurthy Velpandian |
Publsiher | : Springer |
Total Pages | : 535 |
Release | : 2016-02-29 |
ISBN 10 | : 3319254987 |
ISBN 13 | : 9783319254982 |
Language | : EN, FR, DE, ES & NL |
This book comprises an integrated review of ocular therapeutics across all relevant fields. It addresses the real-world requirements of ophthalmologists, pharmacists and optometrists, as observed through working alongside these practitioners for two decades. Knowledge surrounding agents used in ophthalmic practice has, historically, been scattered. The book facilitates understanding of ocular drug therapy by compiling all key aspects of the pharmacology, toxicology, pharmaceutical science, ocular biochemistry and cell biology of these agents. Chapters detail drug transfer across barriers, systemic toxicity of topically applied drugs, autonomic drugs used for diagnostics, as well as anti-inflammatory, antiallergic, glaucoma and antimicrobial therapies, and avenues for the development of new ocular drugs. Applications of extemporaneously prepared formulations are described to inform day-to-day clinical practice. The use of mucoadhesive polymers in tear substitutes, ocular drug delivery systems, stem cell therapy, pharmacogenomics and antiangiogenic ocular chemotherapy are also explored. The book also provides insights from drugs of herbal origin, and a historical perspective on drugs for ocular use. Practicing and resident ophthalmologists, optometrists, pharmacists, nursing professionals, scholars in ocular drug research and students will equally benefit from this comprehensive guide.
Ocular Periphery and Disorders
Author | : Darlene A. Dartt,Peter Bex,Patricia D'Amore |
Publsiher | : Academic Press |
Total Pages | : 553 |
Release | : 2011 |
ISBN 10 | : 0123820421 |
ISBN 13 | : 9780123820426 |
Language | : EN, FR, DE, ES & NL |
This selection of articles from the Encyclopedia of the Eye is the first single-volume overview presenting articles on the function, biology, physiology, and pathology of the structures of the ocular periphery, as well as the related disorders and their treatment. The peripheral structures are implicated in a number of important diseases, including optic neuritis, thyroid eye disease, and strabismus. The volume offers a basic science background of these topics rather than a strictly clinical focus. The first single volume to integrate comparative studies into a comprehensive resource on the neuroscience of the ocular periphery Chapters are carefully selected from the Encyclopedia of the Eye by the world's leading vision researchers The best researchers in the field provide their conclusions in the context of the latest experimental results
Drug Delivery for the Retina and Posterior Segment Disease
Author | : Jayvadan K. Patel,Vijaykumar Sutariya,Jagat Rakesh Kanwar,Yashwant V. Pathak |
Publsiher | : Springer |
Total Pages | : 494 |
Release | : 2018-10-08 |
ISBN 10 | : 3319958070 |
ISBN 13 | : 9783319958071 |
Language | : EN, FR, DE, ES & NL |
This book addresses the issues relating to a wide variety of ocular diseases from which millions of people suffer. Long-term challenges include visual impairment and ocular blindness. Certain ocular diseases are quite rare, whereas others, such as cataracts, age-related macular degeneration (AMD), and glaucoma, are very common, especially in the aging population. A rapid expansion of new technologies in ocular drug delivery and new drug candidates, including biologics, to treat these challenging diseases in the retina and posterior segments of the eye have recently emerged. These approaches are necessary because the eye has many unique barriers to drug delivery. Thus, this timely reference Drug Delivery for the Retina and Posterior Segment Disease compiles and analyzes recent advances in the research and development of drug delivery systems for retina and posterior segment diseases of the eye, with an emphasis on the use of implantable devices, iontophoresis as well as micro- and nanoparticles.
Lacrimal Gland Tear Film and Dry Eye Syndromes 3
Author | : David A. Sullivan,Michael E. Stern,Kazuo Tsubota,Darlene A. Dartt,Rose M. Sullivan,B. Britt Bromberg |
Publsiher | : Springer |
Total Pages | : 1399 |
Release | : 2003-01-31 |
ISBN 10 | : 9780306472824 |
ISBN 13 | : 0306472821 |
Language | : EN, FR, DE, ES & NL |
During the past several decades, a significant international research effort has been directed towards understanding the composition and regulation of the preocular tear film. This effort has been motivated by the recognition that the tear film plays a critical role in maintaining corneal and conjunctival integrity, protecting against microbial challenge and preserving visual acuity. In addition, research has been stimulated by the knowledge that alteration or deficiency of the tear film, which occurs in numerous individuals throughout the world, may lead to desiccation of the ocular surface, ulceration and perforation of the cornea, an increased incidence of infectious disease, and potentionally pronounced visual disability and blindness.
Clinical Ocular Pharmacology
Author | : Jimmy D. Bartlett,Siret D. Jaanus |
Publsiher | : Butterworth-Heinemann |
Total Pages | : 978 |
Release | : 1984 |
ISBN 10 | : |
ISBN 13 | : UOM:39015006017100 |
Language | : EN, FR, DE, ES & NL |
Written by experts in the field, this comprehensive resource offers valuable information on the practical uses of drugs in primary eye care. Discussions of the pharmacology of ocular drugs such as anti-infective agents, anti-glaucoma drugs, and anti-allergy drugs lead to more in-depth information on ocular drugs used to treat a variety of disorders, including diseases of the eyelids, corneal diseases, ocular infections, and glaucoma. The book also covers ocular toxicology, focusing on drug interactions, ocular effects of systemic drugs, and life-threatening systemic emergencies.
Ocular Drug Delivery Advances Challenges and Applications
Author | : Richard T. Addo |
Publsiher | : Springer |
Total Pages | : 185 |
Release | : 2016-11-16 |
ISBN 10 | : 3319476912 |
ISBN 13 | : 9783319476919 |
Language | : EN, FR, DE, ES & NL |
The eye is a computerized system that has been designed for self-defense, and these defense mechanisms create challenges in administration of medications to the eye. Therefore, ocular drug delivery has been a major challenge to drug delivery researchers. There are on-going studies, in search of treatment especially for the diseases affecting the posterior segment of the eye. This book gives and overview of the background of ocular drug delivery and is unique for pharmacists, medical practitioners, students and drug delivery researchers.
Anatomy Ocular physiology Biochemistry and genetics Pathology Microbiology Immunology Growth and senescence Optics Therapeutics Lasers and instrument technology Basic biostatistical and epidemiological terms
Author | : Louise Bye,Neil Modi,Miles Stanford |
Publsiher | : OUP Oxford |
Total Pages | : 288 |
Release | : 2013-05-23 |
ISBN 10 | : 0199584990 |
ISBN 13 | : 9780199584994 |
Language | : EN, FR, DE, ES & NL |
An indispensable and fully comprehensive textbook, this covers the basic sciences in ophthalmology and is the only book you need to pass the FRCOphth Part 1 exam.
Chitin Chitosan
Author | : Rajendra Dongre |
Publsiher | : BoD – Books on Demand |
Total Pages | : 382 |
Release | : 2018-07-18 |
ISBN 10 | : 1789234069 |
ISBN 13 | : 9781789234060 |
Language | : EN, FR, DE, ES & NL |
Chitin is the second most abundant biopolymer after cellulose and is a resourceful copious and cheap biomaterial discovered in 1859 owing to significant industrial and technological utility. Raw chitin-chitosan resembles keratin in its biological functions. Chitin chemistry vastly developed via innate unparalleled biological features and exceptional physicochemical characters. Chitosan endures assorted chemical/physical modifications easily at free proactive functionalities, yet intact bulk properties are achieved through processing, viz., film, membrane, composite, hybrid, nanofibre, nanoparticle, hydrogel and scaffolds. Rapidly lessen bioresources signify chitosan as an option due to renewable eco-friendliness and drive embryonic myriad applications in S