Non-Canonical Autophagy

Non-Canonical Autophagy
Author: Lorenzo Galluzzi,Giulia Petroni
Publsiher: Academic Press
Total Pages: 250
Release: 2021-05-15
ISBN 10: 9780128205389
ISBN 13: 0128205385
Language: EN, FR, DE, ES & NL

Non-Canonical Autophagy Book Review:

Non-canonical Autophagy: Mechanisms and Pathophysiological Implications outlines the differences between 'canonical' and 'non-canonical' forms of autophagy, highlighting the discoveries concerning the molecular mechanisms underlying these unconventional forms of autophagy and the advancements in pathophysiological features of 'non-canonical' autophagy. The book discusses all forms of 'non-canonical' autophagy and the complexity of autophagy-dependent cell death. Readers will gain a better understanding of mechanisms underlying 'non-canonical' autophagy so that they can interpret the biological effects of autophagy correctly and identify reliable, novel and effective treatment strategies. Presents the most advanced information surrounding the molecular mechanisms underlying non-canonical autophagy Outlines the increasing evidence regarding the involvement of non-canonical autophagy in multiple physiological and pathological processes Discusses the therapeutic potential of autophagy modulators and the obstacles that have limited their development

Regulation of B Cell Responses by Non-canonical Autophagy

Regulation of B Cell Responses by Non-canonical Autophagy
Author: Paula Maldonado Villavicencio
Publsiher: Anonim
Total Pages: 329
Release: 2019
ISBN 10:
ISBN 13: OCLC:1197752180
Language: EN, FR, DE, ES & NL

Regulation of B Cell Responses by Non-canonical Autophagy Book Review:

Autophagy in Health and Disease

Autophagy in Health and Disease
Author: Roberta A. Gottlieb
Publsiher: Academic Press
Total Pages: 227
Release: 2012-10-16
ISBN 10: 0123851017
ISBN 13: 9780123851017
Language: EN, FR, DE, ES & NL

Autophagy in Health and Disease Book Review:

Autophagy in Health and Disease offers an overview of the latest research in autophagy with a translational emphasis. This publication takes scientific research in autophagy a step further and offers integrated content with advancements in autophagy from cell biology and biochemical research to clinical treatments. A necessary reference for the bookshelf of medical and scientific researchers and students, Autophagy in Health and Disease presents high quality, reputable information on autophagy, allowing the reader quick access to the most applicable information. Discusses current understanding of the roles of autophagy in health and disease Covers the background of autophagy, the development of tools and therapeutics to measure and modulate autophagy, and autophagy in tissues and disease processes Features an accompanying website with figures and tables

Autophagy in Autoimmunity

Autophagy in Autoimmunity
Author: Xu-jie Zhou,Panayotis Verginis,Jennifer Martinez,Marko Radic
Publsiher: Frontiers Media SA
Total Pages: 161
Release: 2019-05-15
ISBN 10: 2889458121
ISBN 13: 9782889458127
Language: EN, FR, DE, ES & NL

Autophagy in Autoimmunity Book Review:

Autophagy of the Nervous System

Autophagy of the Nervous System
Author: Zhenyu Yue,Charleen T. Chu
Publsiher: World Scientific
Total Pages: 426
Release: 2012
ISBN 10: 9814350443
ISBN 13: 9789814350440
Language: EN, FR, DE, ES & NL

Autophagy of the Nervous System Book Review:

What is autophagy? Why would neurons or other brain cells digest parts of themselves through autophagy? How can autophagy save the lives of cells under some conditions, but act as a culprit or accomplice to cell death in others? How does dysfunction of autophagy contribute to neurological diseases and can it be repaired or restored? This book addresses these questions and provide an expert view of the emerging concepts in autophagy research, focusing on autophagic processes and regulation in neurons. Current experimental evidence for both evolutionarily conserved and specialized regulatory mechanisms for autophagy in the mammalian nervous system will be presented. Advances in our understanding of the complex interplay of autophagy induction and downregulation will be discussed in relation to the critical balance needed to modulate neuroprotection versus neurodegeneration in the context of neurological diseases including Alzheimer's, Parkinson's, Huntington's, ischemic-hypoxic and lysosomal diseases.

Non-canonical Cyclic Nucleotides

Non-canonical Cyclic Nucleotides
Author: Roland Seifert
Publsiher: Springer
Total Pages: 387
Release: 2017-04-28
ISBN 10: 3319526731
ISBN 13: 9783319526737
Language: EN, FR, DE, ES & NL

Non-canonical Cyclic Nucleotides Book Review:

The cyclic purine nucleotides 3’,5’-cAMP and 3’,5’-cGMP are well-established second messengers. cGMP has recently been covered in a volume of the Handbook of Experimental Pharmacology (volume 191). In addition to 3’,5’-cAMP and 3’,5’-cGMP, so-called non-canonical cyclic nucleotides exist. These comprise the cyclic pyrimidine nucleotides 3’,5’-cCMP and 3’,5’-cUMP, the purine nucleotide 3’,5’-cIMP, the 2’,3’-nucleoside monophosphates and cyclic dinucleotides. In this volume of the Handbook of Pharmacology, word-leading experts in the field summarize our current knowledge on these non-canonical cyclic nucleotides, discuss open questions, future research directions and the pharmacotherapeutic implications. Special emphasis will be given to the emerging roles of 3’,5’-cCMP and 3’,5’-cUMP as second messengers with regard to generators, effectors, biological functions, inactivation and bacterial toxins. The role of 3’,5’-cIMP as potential second messenger will also be critically discussed. Furthermore, we will consider transport of cyclic nucleotides and their potential role as first messengers. The role of the cyclic dinucleotide cGAMP in the immune system will covered, too. Lastly, the book will present important methodological aspects ranging from mass-spectrometric methods for cyclic nucleotide detection to the synthesis of nucleotide analogs as experimental tools and holistic methods for analysis of cyclic nucleotide effects.

Looking Beyond Pattern Recognition: Perturbations in Cellular Homeostasis and Metabolism as Emerging Regulators of Dendritic Cell Function

Looking Beyond Pattern Recognition: Perturbations in Cellular Homeostasis and Metabolism as Emerging Regulators of Dendritic Cell Function
Author: Fabiola Osorio,Bart Everts
Publsiher: Frontiers Media SA
Total Pages: 329
Release: 2019-12-09
ISBN 10: 2889632288
ISBN 13: 9782889632282
Language: EN, FR, DE, ES & NL

Looking Beyond Pattern Recognition: Perturbations in Cellular Homeostasis and Metabolism as Emerging Regulators of Dendritic Cell Function Book Review:

Autophagic Degradation of Organelles in the Yeast Saccharomyces Cerevisiae

Autophagic Degradation of Organelles in the Yeast Saccharomyces Cerevisiae
Author: Anonim
Publsiher: Anonim
Total Pages: 696
Release: 2008
ISBN 10:
ISBN 13: OCLC:794749498
Language: EN, FR, DE, ES & NL

Autophagic Degradation of Organelles in the Yeast Saccharomyces Cerevisiae Book Review:

For some of the studies a fluorescent biosensor expressed in the cytosol, or targeted to mitochondria or the nucleus, was used in order to monitor autophagic degradation of the respective compartment/organelle. Here the assay was based upon a genetically encoded dual colour-emission biosensor. Rosella, the fusion of a relatively pH-insensitive fast-maturing variant of the red fluorescent protein DsRed, with a pH-sensitive variant of GFP. By virtue of being targeted to different compartments/organelles the dual colour nature of Rosella biosensor, allows unambiguous distinction between material delivered to the vacuole (red fluorescence, but pH-based loss of green fluorescence) and that localised in cytosol, mitochondria and the nucleus (red and green fluorescence retained). This novel assay allows not only fast and simple qualitative analysis, but also quantitative analysis of cells in a population undergoing autophagy. The autophagic degradation of the cytosol was found to be fully dependent on the macroautophagic machinery. On the other hand, autophagic degradation of the nucleus can be observed to occur 24 hours following nitrogen starvation and either independently of some ATG genes (e.g. ATG5 and ATG12), but does rely on others (e.g. ATG3 and ATG4). Other data concerning dependence on components of the NV-junction and complexes previously identified as being involved in microautophagic processes suggest that the process of nucleophagy observed and described in this thesis is different from the PMN.

Autophagy in Current Trends in Cellular Physiology and Pathology

Autophagy in Current Trends in Cellular Physiology and Pathology
Author: Nikolai Gorbunov,E. Marion Schneider
Publsiher: BoD – Books on Demand
Total Pages: 526
Release: 2016-11-10
ISBN 10: 9535127268
ISBN 13: 9789535127260
Language: EN, FR, DE, ES & NL

Autophagy in Current Trends in Cellular Physiology and Pathology Book Review:

Autophagy in Current Trends in Cellular Physiology and Pathology is addressed to one of the fundamental molecular mechanisms - autophagy- evolutionarily adopted by cells for processing of unnecessary or malfunctioned constituents and shaping intracellular structures, adjusting them to environmental conditions, aging, disease, neoplasia, and damages over their life period. Particular attention is paid to autophagy-mediated barrier processes of selective sequestration and recycling of impaired organelles and degradation of invading microorganisms, that is, the processes sustaining intrinsic resistance to stress, tissue degeneration, toxic exposures, and infections. The presented topics encompass personal experience and visions of the chapter contributors and the editors; the book chapters include a broad analysis of literature on biology of autophagy.

Protein Degradation

Protein Degradation
Author: R. John Mayer,Aaron J. Ciechanover,Martin Rechsteiner
Publsiher: Wiley-VCH
Total Pages: 393
Release: 2005-04-15
ISBN 10: 9783527308378
ISBN 13: 3527308377
Language: EN, FR, DE, ES & NL

Protein Degradation Book Review:

The first volume in a new series dedicated to protein degradation, this book lays the foundations of targeted protein breakdown via the ubiquitin pathway. The outstanding importance of the ubiquitin pathway has been recognized with the 2004 Nobel Prize in Chemistry for Aaaron Chiechanover, Avram Hershko, and Irwin Rose. Aaron Ciechanover is one of the editors of this series, and Avram Hershko has contributed to the opening chapter of the present volume. Drawing on the the expertise of two Nobel prize winners, this handy reference compiles information on the initial steps of the ubiquitin pathway. Starting out with a broad view of protein degradation and its functions in cellular regulation, it then goes on to examine the molecular mechanisms of ubiquitin conjugation and recycling in detail. All currently known classes of ubiquitin protein ligases are treated here, including latest structural data on these enzymes. Further volumes in the series cover the function of the proteasome, and the roles of the ubiquitin pathway in regulating key cellular processes, as well as its pathophysiological disease states. Required reading for molecular biologists, cell biologists and physiologists with an interest in protein degradation.

Autophagy Regulation of Innate Immunity

Autophagy Regulation of Innate Immunity
Author: Jun Cui
Publsiher: Springer Nature
Total Pages: 203
Release: 2019-11-14
ISBN 10: 981150606X
ISBN 13: 9789811506062
Language: EN, FR, DE, ES & NL

Autophagy Regulation of Innate Immunity Book Review:

This book discusses novel concepts and discoveries concerning the regulation of innate immunity by autophagy and autophagy-related proteins. In the past decade, there have been major advances in our understanding of the molecular mechanisms of autophagy and its physiological functions. This book highlights emerging studies on the underlying mechanisms of autophagy regulation of innate immunity, including inflammation, antiviral immunity and anti-bacterial responses and the signaling pathways that prompt or inhibit the initiation and progression of related diseases. It also offers new ideas and strategies for future drugs based on manipulating autophagy, especially selective autophagy mediated by cargo receptors. Providing a comprehensive overview of the autophagy regulation of innate immunity, it is a valuable resource for graduate students and researchers in the fields of immunology, cell biology and translational medicine.

Autophagy

Autophagy
Author: Nicholas Ktistakis,Oliver Florey
Publsiher: Humana Press
Total Pages: 741
Release: 2019-01-05
ISBN 10: 9781493988723
ISBN 13: 1493988727
Language: EN, FR, DE, ES & NL

Autophagy Book Review:

This volume details a comprehensive and extensive set of protocols for the study of autophagy in vitro and in vivo. Chapters focus on mammals, various model organisms, and provide protocols for the study of autophagy-related processes outside of the canonical autophagy pathways. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Autophagy: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Autophagy Networks in Inflammation

Autophagy Networks in Inflammation
Author: Maria Chiara Maiuri,Daniela De Stefano
Publsiher: Springer
Total Pages: 403
Release: 2016-08-17
ISBN 10: 3319300792
ISBN 13: 9783319300795
Language: EN, FR, DE, ES & NL

Autophagy Networks in Inflammation Book Review:

Autophagy principally serves an adaptive function to protect organisms against diverse human pathologies, including cancer and neurodegeneration. Recent developments using in vitro, ex vivo and in vivo models show the involvement of the autophagy pathway in immunity and inflammation. Moreover, direct interactions between autophagy proteins and immune signalling molecules have also been demonstrated. Defects in autophagy - similar to cancer, neurodegenerative diseases and aging - through autophagy gene mutation and/or microbial antagonism, may underlie the pathogenesis of many infectious diseases and inflammatory syndromes. In spite of the increasing awareness of the importance of autophagy in these pathophysiological conditions, this process remains underestimated and is often overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these diseases are still poorly understood. This book reviews the recent advances regarding the functions of the autophagy pathway and autophagy proteins in immunity and inflammation, focusing on their role in self-nonself distinction, their implications in innate and adaptive immune responses and their dysregulation in the pathology of certain inflammatory and autoimmune diseases.

Membrane Biogenesis

Membrane Biogenesis
Author: Jos A.F. Op den Kamp
Publsiher: Springer Science & Business Media
Total Pages: 477
Release: 2013-06-29
ISBN 10: 3642731848
ISBN 13: 9783642731846
Language: EN, FR, DE, ES & NL

Membrane Biogenesis Book Review:

Many individual aspects of the dynamics and assembly of biological membranes have been studied in great detail. Cell biological approaches, advanced genetics, biophysics and biochemistry have greatly contributed to an increase in our knowledge in this field.lt is obvious however, that the three major membrane constituents - lipids, proteins and carbohydrates- are studied, in most cases separately and that a coherent overview of the various aspects of membrane biogenesis is not readily available. The NATO Advanced Study Institute on "New Perspectives in the Dynamics of Assembly of Biomembranes" intended to provide such an overview: it was set up to teach students and specialists the achievements obtained in the various research areas and to try and integrate the numerous aspects of membrane assembly into a coherent framework. The articles in here reflect this. Statting with detailed contributions on phospholipid structure, dynamics, organization and biogenesis, an up to date overview of the basic, lipidic backbone of biomembranes is given. Extensive progress is made in the research on membrane protein biosynthesis. In particular the post- and co-translational modification processes of proteins, the mechanisms of protein translocation and the sorting mechanisms which are necessary to direct proteins to their final, intra - or extracellular destination have been characterized in detail. Modern genetic approaches were indispensable in this research area: gene cloning, hybrid protein construction, site directed mutagenesis and sequencing techniques elucidated many functional aspects of specific nucleic acid and amino acid sequences.

Cell Death

Cell Death
Author: Tobias Ntuli
Publsiher: BoD – Books on Demand
Total Pages: 446
Release: 2015-12-16
ISBN 10: 9535122363
ISBN 13: 9789535122364
Language: EN, FR, DE, ES & NL

Cell Death Book Review:

This book is a collection of selected and relevant research, concerning the developments within the Cell Death field of study. Each contribution comes as a separate chapter complete in itself but directly related to the books topics and objectives. The target audience comprises scholars and specialists in the field.

Induction of Central Nervous System Disease by the Adaptive Immune Response

Induction of Central Nervous System Disease by the Adaptive Immune Response
Author: Robert Weissert,Fabienne Brilot
Publsiher: Frontiers Media SA
Total Pages: 329
Release: 2017-11-23
ISBN 10: 2889453472
ISBN 13: 9782889453474
Language: EN, FR, DE, ES & NL

Induction of Central Nervous System Disease by the Adaptive Immune Response Book Review:

Over the last years it has become evident that many neurological diseases of the central nervous system (CNS) are induced by a specific adaptive immune response directed against molecules expressed on CNS-resident cells. Well-recognized examples are anti-N-Methyl-D-Aspartate Receptor (NMDAR) encephalitis which is characterized by the presence of antibodies against neuron-expressed NMDAR, or neuromyelitis optica (NMO), induced by antibodies to astrocyte-expressed aquaporin-4. Many more examples exist, and antibodies, and T or/and B cells have increasingly been associated with CNS disease. Often the symptoms of these diseases have not been typically reported to have an immune aetiology. Beside classical neurological symptoms like ataxia, vision disturbance, and motor or sensory symptoms, these can include cognitive disturbances, behavioral abnormalities, or/and epileptic seizures. Although much has been learned regarding the pathophysiology of prototypic examples of these disorders, there are still major gaps in our understanding of their biology. This may be due to the fact that they are rare diseases, and their therapies are still very limited. This research topic includes contributions addressing the analysis of the adaptive immune response driving disease including target antigens, molecular epitope mapping, and factors involved in the disease pathogenesis such as complement activation cascades, genetic and genomic regulation, as well as environmental triggers. Diagnostic criteria and methods, and treatment are also discussed. The overall aim of the volume is to review progress in our pathophysiological understanding of immune-mediated CNS disorders in order to advance diagnostic and therapeutic approaches, and ultimately improve outcomes for patients.

Autophagy

Autophagy
Author: Daniel Klionsky
Publsiher: CRC Press
Total Pages: 327
Release: 2003-12-15
ISBN 10: 1498713270
ISBN 13: 9781498713276
Language: EN, FR, DE, ES & NL

Autophagy Book Review:

Starting in the early 1970s, a type of programmed cell death called apoptosis began to receive attention. Over the next three decades, research in this area continued at an accelerated rate. In the early 1990s, a second type of programmed cell death, autophagy, came into focus. Autophagy has been studied in mammalian cells for many years. The recen

Autophagy in Infection and Immunity

Autophagy in Infection and Immunity
Author: Beth Levine,Tamotsu Yoshimori,Vojo Deretic
Publsiher: Springer Science & Business Media
Total Pages: 339
Release: 2009-10-03
ISBN 10: 9783642003028
ISBN 13: 3642003028
Language: EN, FR, DE, ES & NL

Autophagy in Infection and Immunity Book Review:

Autophagy is a fundamental biological process that enables cells to autodigest their own cytosol during starvation and other forms of stress. It has a growing spectrum of acknowledged roles in immunity, aging, development, neurodegeneration, and cancer biology. An immunological role of autophagy was first recognized with the discovery of autophagy’s ability to sanitize the cellular interior by killing intracellular microbes. Since then, the repertoire of autophagy’s roles in immunity has been vastly expanded to include a diverse but interconnected portfolio of regulatory and effector functions. Autophagy is an effector of Th1/Th2 polarization; it fuels MHC II presentation of cytosolic (self and microbial) antigens; it shapes central tolerance; it affects B and T cell homeostasis; it acts both as an effector and a regulator of Toll-like receptor and other innate immunity receptor signaling; and it may help ward off chronic inflammatory disease in humans. With such a multitude of innate and adaptive immunity functions, the study of autophagy in immunity is one of the most rapidly growing fields of contemporary immunological research. This book introduces the reader to the fundamentals of autophagy, guides a novice and the well-informed reader alike through different immunological aspects of autophagy as well as the countermeasures used by highly adapted pathogens to fight autophagy, and provides the expert with the latest, up-to-date information on the specifics of the leading edge of autophagy research in infection and immunity.

Novel and Complimentary Approaches to Prostate Cancer Therapy

Novel and Complimentary Approaches to Prostate Cancer Therapy
Author: Randie Hee Kim
Publsiher: Anonim
Total Pages: 258
Release: 2009
ISBN 10:
ISBN 13: UCAL:X83519
Language: EN, FR, DE, ES & NL

Novel and Complimentary Approaches to Prostate Cancer Therapy Book Review:

Autophagy: from Big Data to Physiological Significance

Autophagy: from Big Data to Physiological Significance
Author: Ioannis Nezis,Sovan Sarkar,Maria Ines Vaccaro
Publsiher: Frontiers Media SA
Total Pages: 329
Release: 2020-02-10
ISBN 10: 2889634825
ISBN 13: 9782889634828
Language: EN, FR, DE, ES & NL

Autophagy: from Big Data to Physiological Significance Book Review: