Non Canonical Autophagy

Non Canonical Autophagy
Author: Lorenzo Galluzzi,Giulia Petroni
Publsiher: Academic Press
Total Pages: 250
Release: 2021-05-01
ISBN 10: 0128209119
ISBN 13: 9780128209110
Language: EN, FR, DE, ES & NL

Non Canonical Autophagy Book Review:

Non-canonical Autophagy: Mechanisms and Pathophysiological Implications outlines the differences between ‘canonical’ and ‘non-canonical’ forms of autophagy, highlighting the discoveries concerning the molecular mechanisms underlying these unconventional forms of autophagy and the advancements in pathophysiological features of ‘non-canonical’ autophagy. Non-canonical Autophagy: Mechanisms and Pathophysiological Implications also discusses all the forms ‘non-canonical’ autophagy and the complexity of autophagy-dependent cell death as the challenges and pitfalls in the development of clinically viable modulators of autophagy. This book aims to give readers a better understanding of mechanisms underlying ‘non-canonical’ autophagy so that they can interpret biological effects of autophagy correctly and identify reliable novel and effective treatment strategies. Presents the most advanced information regarding the molecular mechanism underlying non-canonical autophagy Outlines the increasing evidence regarding the involvement of non-canonical autophagy in multiple physiological and pathological processes Discusses the therapeutic potential of autophagy modulators and the obstacles that have limited their development

Regulation of B Cell Responses by Non canonical Autophagy

Regulation of B Cell Responses by Non canonical Autophagy
Author: Paula Maldonado Villavicencio
Publsiher: Unknown
Total Pages: 329
Release: 2019
ISBN 10:
ISBN 13: OCLC:1197752180
Language: EN, FR, DE, ES & NL

Regulation of B Cell Responses by Non canonical Autophagy Book Review:

Non canonical Cyclic Nucleotides

Non canonical Cyclic Nucleotides
Author: Roland Seifert
Publsiher: Springer
Total Pages: 387
Release: 2017-04-28
ISBN 10: 3319526731
ISBN 13: 9783319526737
Language: EN, FR, DE, ES & NL

Non canonical Cyclic Nucleotides Book Review:

The cyclic purine nucleotides 3’,5’-cAMP and 3’,5’-cGMP are well-established second messengers. cGMP has recently been covered in a volume of the Handbook of Experimental Pharmacology (volume 191). In addition to 3’,5’-cAMP and 3’,5’-cGMP, so-called non-canonical cyclic nucleotides exist. These comprise the cyclic pyrimidine nucleotides 3’,5’-cCMP and 3’,5’-cUMP, the purine nucleotide 3’,5’-cIMP, the 2’,3’-nucleoside monophosphates and cyclic dinucleotides. In this volume of the Handbook of Pharmacology, word-leading experts in the field summarize our current knowledge on these non-canonical cyclic nucleotides, discuss open questions, future research directions and the pharmacotherapeutic implications. Special emphasis will be given to the emerging roles of 3’,5’-cCMP and 3’,5’-cUMP as second messengers with regard to generators, effectors, biological functions, inactivation and bacterial toxins. The role of 3’,5’-cIMP as potential second messenger will also be critically discussed. Furthermore, we will consider transport of cyclic nucleotides and their potential role as first messengers. The role of the cyclic dinucleotide cGAMP in the immune system will covered, too. Lastly, the book will present important methodological aspects ranging from mass-spectrometric methods for cyclic nucleotide detection to the synthesis of nucleotide analogs as experimental tools and holistic methods for analysis of cyclic nucleotide effects.

Membrane Biogenesis

Membrane Biogenesis
Author: Jos A.F. Op den Kamp
Publsiher: Springer Science & Business Media
Total Pages: 477
Release: 2013-06-29
ISBN 10: 3642731848
ISBN 13: 9783642731846
Language: EN, FR, DE, ES & NL

Membrane Biogenesis Book Review:

Many individual aspects of the dynamics and assembly of biological membranes have been studied in great detail. Cell biological approaches, advanced genetics, biophysics and biochemistry have greatly contributed to an increase in our knowledge in this field.lt is obvious however, that the three major membrane constituents - lipids, proteins and carbohydrates- are studied, in most cases separately and that a coherent overview of the various aspects of membrane biogenesis is not readily available. The NATO Advanced Study Institute on "New Perspectives in the Dynamics of Assembly of Biomembranes" intended to provide such an overview: it was set up to teach students and specialists the achievements obtained in the various research areas and to try and integrate the numerous aspects of membrane assembly into a coherent framework. The articles in here reflect this. Statting with detailed contributions on phospholipid structure, dynamics, organization and biogenesis, an up to date overview of the basic, lipidic backbone of biomembranes is given. Extensive progress is made in the research on membrane protein biosynthesis. In particular the post- and co-translational modification processes of proteins, the mechanisms of protein translocation and the sorting mechanisms which are necessary to direct proteins to their final, intra - or extracellular destination have been characterized in detail. Modern genetic approaches were indispensable in this research area: gene cloning, hybrid protein construction, site directed mutagenesis and sequencing techniques elucidated many functional aspects of specific nucleic acid and amino acid sequences.

Autophagy in Health and Disease

Autophagy in Health and Disease
Author: Roberta A. Gottlieb
Publsiher: Academic Press
Total Pages: 227
Release: 2012-10-16
ISBN 10: 0123851017
ISBN 13: 9780123851017
Language: EN, FR, DE, ES & NL

Autophagy in Health and Disease Book Review:

Autophagy in Health and Disease offers an overview of the latest research in autophagy with a translational emphasis. This publication takes scientific research in autophagy a step further and offers integrated content with advancements in autophagy from cell biology and biochemical research to clinical treatments. A necessary reference for the bookshelf of medical and scientific researchers and students, Autophagy in Health and Disease presents high quality, reputable information on autophagy, allowing the reader quick access to the most applicable information. Discusses current understanding of the roles of autophagy in health and disease Covers the background of autophagy, the development of tools and therapeutics to measure and modulate autophagy, and autophagy in tissues and disease processes Features an accompanying website with figures and tables

Autophagy

Autophagy
Author: Nicholas Ktistakis,Oliver Florey
Publsiher: Humana Press
Total Pages: 741
Release: 2019-01-05
ISBN 10: 9781493988723
ISBN 13: 1493988727
Language: EN, FR, DE, ES & NL

Autophagy Book Review:

This volume details a comprehensive and extensive set of protocols for the study of autophagy in vitro and in vivo. Chapters focus on mammals, various model organisms, and provide protocols for the study of autophagy-related processes outside of the canonical autophagy pathways. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Autophagy: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Autophagy in Autoimmunity

Autophagy in Autoimmunity
Author: Xu-jie Zhou,Panayotis Verginis,Jennifer Martinez,Marko Radic
Publsiher: Frontiers Media SA
Total Pages: 161
Release: 2019-05-15
ISBN 10: 2889458121
ISBN 13: 9782889458127
Language: EN, FR, DE, ES & NL

Autophagy in Autoimmunity Book Review:

Cell Death

Cell Death
Author: Tobias Ntuli
Publsiher: BoD – Books on Demand
Total Pages: 446
Release: 2015-12-16
ISBN 10: 9535122363
ISBN 13: 9789535122364
Language: EN, FR, DE, ES & NL

Cell Death Book Review:

This book is a collection of selected and relevant research, concerning the developments within the Cell Death field of study. Each contribution comes as a separate chapter complete in itself but directly related to the books topics and objectives. The target audience comprises scholars and specialists in the field.

Autophagy in Current Trends in Cellular Physiology and Pathology

Autophagy in Current Trends in Cellular Physiology and Pathology
Author: Nikolai Gorbunov,E. Marion Schneider
Publsiher: BoD – Books on Demand
Total Pages: 526
Release: 2016-11-10
ISBN 10: 9535127268
ISBN 13: 9789535127260
Language: EN, FR, DE, ES & NL

Autophagy in Current Trends in Cellular Physiology and Pathology Book Review:

Autophagy in Current Trends in Cellular Physiology and Pathology is addressed to one of the fundamental molecular mechanisms - autophagy- evolutionarily adopted by cells for processing of unnecessary or malfunctioned constituents and shaping intracellular structures, adjusting them to environmental conditions, aging, disease, neoplasia, and damages over their life period. Particular attention is paid to autophagy-mediated barrier processes of selective sequestration and recycling of impaired organelles and degradation of invading microorganisms, that is, the processes sustaining intrinsic resistance to stress, tissue degeneration, toxic exposures, and infections. The presented topics encompass personal experience and visions of the chapter contributors and the editors; the book chapters include a broad analysis of literature on biology of autophagy.

Prognostic and Therapeutic Applications of Rkip in Cancer

Prognostic and Therapeutic Applications of Rkip in Cancer
Author: Benjamin Bonavida,Stavroula Baritaki
Publsiher: Academic Press
Total Pages: 504
Release: 2020-03-02
ISBN 10: 0128196122
ISBN 13: 9780128196120
Language: EN, FR, DE, ES & NL

Prognostic and Therapeutic Applications of Rkip in Cancer Book Review:

Prognostic and Therapeutic Applications of RKIP in Cancer provides updated reviews on the chemistry, signaling, pre-clinical and clinical activities, and role of RKIP expression levels for diagnostics, prognosis and potential interventions. The development of novel compounds and conjugates that selectively induce RKIP expression in cancer open a novel era of new therapeutics and their potential in the treatment of highly resistant cancers and metastases. Edited and written by internationally renowned experts in the field of novel therapeutics for cancer, this book is a valuable source for cancer researchers, medical scientists, clinicians, clinical pharmacologists, and graduate students. Provides an update from experts in the field on diagnostics, prognostics and therapeutics Brings a clear overview of recent findings and references, as well as summaries, significant molecular pathways, and conclusions in each chapter Provides a general introductory chapter on contributions in the field and a chapter summary, with synthesized findings and a projection of future goals

Autophagy of the Nervous System

Autophagy of the Nervous System
Author: Zhenyu Yue,Charleen T. Chu
Publsiher: World Scientific
Total Pages: 426
Release: 2012
ISBN 10: 9814350443
ISBN 13: 9789814350440
Language: EN, FR, DE, ES & NL

Autophagy of the Nervous System Book Review:

What is autophagy? Why would neurons or other brain cells digest parts of themselves through autophagy? How can autophagy save the lives of cells under some conditions, but act as a culprit or accomplice to cell death in others? How does dysfunction of autophagy contribute to neurological diseases and can it be repaired or restored? This book addresses these questions and provide an expert view of the emerging concepts in autophagy research, focusing on autophagic processes and regulation in neurons. Current experimental evidence for both evolutionarily conserved and specialized regulatory mechanisms for autophagy in the mammalian nervous system will be presented. Advances in our understanding of the complex interplay of autophagy induction and downregulation will be discussed in relation to the critical balance needed to modulate neuroprotection versus neurodegeneration in the context of neurological diseases including Alzheimer's, Parkinson's, Huntington's, ischemic-hypoxic and lysosomal diseases.

Looking Beyond Pattern Recognition Perturbations in Cellular Homeostasis and Metabolism as Emerging Regulators of Dendritic Cell Function

Looking Beyond Pattern Recognition  Perturbations in Cellular Homeostasis and Metabolism as Emerging Regulators of Dendritic Cell Function
Author: Fabiola Osorio,Bart Everts
Publsiher: Frontiers Media SA
Total Pages: 329
Release: 2019-12-09
ISBN 10: 2889632288
ISBN 13: 9782889632282
Language: EN, FR, DE, ES & NL

Looking Beyond Pattern Recognition Perturbations in Cellular Homeostasis and Metabolism as Emerging Regulators of Dendritic Cell Function Book Review:

Induction of Central Nervous System Disease by the Adaptive Immune Response

Induction of Central Nervous System Disease by the Adaptive Immune Response
Author: Robert Weissert,Fabienne Brilot
Publsiher: Frontiers Media SA
Total Pages: 329
Release: 2017-11-23
ISBN 10: 2889453472
ISBN 13: 9782889453474
Language: EN, FR, DE, ES & NL

Induction of Central Nervous System Disease by the Adaptive Immune Response Book Review:

Over the last years it has become evident that many neurological diseases of the central nervous system (CNS) are induced by a specific adaptive immune response directed against molecules expressed on CNS-resident cells. Well-recognized examples are anti-N-Methyl-D-Aspartate Receptor (NMDAR) encephalitis which is characterized by the presence of antibodies against neuron-expressed NMDAR, or neuromyelitis optica (NMO), induced by antibodies to astrocyte-expressed aquaporin-4. Many more examples exist, and antibodies, and T or/and B cells have increasingly been associated with CNS disease. Often the symptoms of these diseases have not been typically reported to have an immune aetiology. Beside classical neurological symptoms like ataxia, vision disturbance, and motor or sensory symptoms, these can include cognitive disturbances, behavioral abnormalities, or/and epileptic seizures. Although much has been learned regarding the pathophysiology of prototypic examples of these disorders, there are still major gaps in our understanding of their biology. This may be due to the fact that they are rare diseases, and their therapies are still very limited. This research topic includes contributions addressing the analysis of the adaptive immune response driving disease including target antigens, molecular epitope mapping, and factors involved in the disease pathogenesis such as complement activation cascades, genetic and genomic regulation, as well as environmental triggers. Diagnostic criteria and methods, and treatment are also discussed. The overall aim of the volume is to review progress in our pathophysiological understanding of immune-mediated CNS disorders in order to advance diagnostic and therapeutic approaches, and ultimately improve outcomes for patients.

Autophagy Biology and Diseases

Autophagy  Biology and Diseases
Author: Zheng-Hong Qin
Publsiher: Springer Nature
Total Pages: 727
Release: 2019-11-27
ISBN 10: 9811506027
ISBN 13: 9789811506024
Language: EN, FR, DE, ES & NL

Autophagy Biology and Diseases Book Review:

This book series consists of 3 volumes covering the basic science (Volume 1), clinical science (Volume 2) and the technology and methodology (Volume 3) of autophagy. Volume 1 focuses on the biology of autophagy, including the signaling pathways, regulating processes and biological functions. Autophagy is a fundamental physiological process in eukaryotic cells. It not only regulates normal cellular homeostasis, and organ development and function, but also plays an important role in the pathogenesis of a wide range of human diseases. Thanks to the rapid development of molecular biology and omic technologies, research on autophagy has boomed in recent decades, and more and more cellular and animal models and state-of the-art technologies are being used to shed light on the complexity of signaling networks involved in the autophagic process. Further, its involvement in biological functions and the pathogenesis of various diseases has attracted increased attention around the globe. Presenting cutting-edge knowledge, this book series is a useful reference resource for researchers and clinicians who are working on or interested in autophagy.

Autophagy Regulation of Innate Immunity

Autophagy Regulation of Innate Immunity
Author: Jun Cui
Publsiher: Springer Nature
Total Pages: 203
Release: 2019-11-14
ISBN 10: 981150606X
ISBN 13: 9789811506062
Language: EN, FR, DE, ES & NL

Autophagy Regulation of Innate Immunity Book Review:

This book discusses novel concepts and discoveries concerning the regulation of innate immunity by autophagy and autophagy-related proteins. In the past decade, there have been major advances in our understanding of the molecular mechanisms of autophagy and its physiological functions. This book highlights emerging studies on the underlying mechanisms of autophagy regulation of innate immunity, including inflammation, antiviral immunity and anti-bacterial responses and the signaling pathways that prompt or inhibit the initiation and progression of related diseases. It also offers new ideas and strategies for future drugs based on manipulating autophagy, especially selective autophagy mediated by cargo receptors. Providing a comprehensive overview of the autophagy regulation of innate immunity, it is a valuable resource for graduate students and researchers in the fields of immunology, cell biology and translational medicine.

Autophagy Networks in Inflammation

Autophagy Networks in Inflammation
Author: Maria Chiara Maiuri,Daniela De Stefano
Publsiher: Springer
Total Pages: 403
Release: 2016-08-17
ISBN 10: 3319300792
ISBN 13: 9783319300795
Language: EN, FR, DE, ES & NL

Autophagy Networks in Inflammation Book Review:

Autophagy principally serves an adaptive function to protect organisms against diverse human pathologies, including cancer and neurodegeneration. Recent developments using in vitro, ex vivo and in vivo models show the involvement of the autophagy pathway in immunity and inflammation. Moreover, direct interactions between autophagy proteins and immune signalling molecules have also been demonstrated. Defects in autophagy - similar to cancer, neurodegenerative diseases and aging - through autophagy gene mutation and/or microbial antagonism, may underlie the pathogenesis of many infectious diseases and inflammatory syndromes. In spite of the increasing awareness of the importance of autophagy in these pathophysiological conditions, this process remains underestimated and is often overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these diseases are still poorly understood. This book reviews the recent advances regarding the functions of the autophagy pathway and autophagy proteins in immunity and inflammation, focusing on their role in self-nonself distinction, their implications in innate and adaptive immune responses and their dysregulation in the pathology of certain inflammatory and autoimmune diseases.

Rambles in Teesdale By the authors of Holiday rambles on the Yorkshire moors

Rambles in Teesdale  By the authors of Holiday rambles on the Yorkshire moors
Author: Teesdale
Publsiher: Unknown
Total Pages: 329
Release: 1877
ISBN 10:
ISBN 13: OXFORD:590967330
Language: EN, FR, DE, ES & NL

Rambles in Teesdale By the authors of Holiday rambles on the Yorkshire moors Book Review:

The Unfolded Protein Response in Cancer

The Unfolded Protein Response in Cancer
Author: Robert Clarke
Publsiher: Springer
Total Pages: 220
Release: 2019-03-01
ISBN 10: 303005067X
ISBN 13: 9783030050672
Language: EN, FR, DE, ES & NL

The Unfolded Protein Response in Cancer Book Review:

This volume presents state-of-the-art information on each of the arms of the unfolded protein response (UPR), how their activation/repression are regulated, integrated, and coordinated, how UPR components affect cancer cell biology and responsiveness to therapeutic interventions, and how UPR components/activities offer potentially novel targets for drug discovery, repurposing, and development. The volume will provide the most recent information on the signaling and regulation of the UPR, explore examples of how the UPR and/or specific components contribute to cancer biology, and identify and explore specific examples of potently new actionable targets for drug discovery and development from within the UPR and its regulation. Unique to the volume will be a specific focus on the UPR and its role in cancer biology, as well as a discussion of the role of the UPR in drug responses and resistance in cancer.

Celiac Disease

Celiac Disease
Author: Luis Rodrigo,Carlos Hernández-Lahoz
Publsiher: BoD – Books on Demand
Total Pages: 100
Release: 2019-01-30
ISBN 10: 1789850495
ISBN 13: 9781789850499
Language: EN, FR, DE, ES & NL

Celiac Disease Book Review:

Celiac disease (CD) occurs in about 1% of people worldwide. Diagnosis rates are increasing due to a true rise in incidence, rather than increased awareness and detection. CD affects genetically susceptible individuals who are triggered by the ingestion of gluten. The disease has many clinical manifestations, ranging from severe to minimally symptomatic or non-symptomatic presentations. Diagnosis requires the presence of duodenal chronic inflammation, and most patients have circulating antibodies against tissue transglutaminase. Our understanding of the basic and clinical aspects of CD increases, which is as a major health problem of almost global occurrence. Case finding, distinguishing CD from other gluten-sensitive conditions, better care, and balanced use of resources are the current challenges.

PI3K signalling

PI3K signalling
Author: Klaus Okkenhaug,Martin Turner, Michael R Gold
Publsiher: Frontiers Media SA
Total Pages: 329
Release: 2015-03-05
ISBN 10: 2889194191
ISBN 13: 9782889194193
Language: EN, FR, DE, ES & NL

PI3K signalling Book Review:

The PI3Ks control many key functions in immune cells. PI3Ks phosphorylate PtdIns(4,5)P2 to yield PtdIns(3,4,5)P3. Initially, PI3K inhibitors such as Wortmannin, LY294002 and Rapamycin were used to establish a central role for Pi3K pathway in immune cells. Considerable progress in understanding the role of this pathway in cells of the immune system has been made in recent years, starting with analysis of various PI3K and Pten knockout mice and subsequently mTOR and Foxo knockout mice. Together, these experiments have revealed how PI3Ks control B cell and T cell development, T helper cell differentiation, regulatory T cell development and function, B cell and T cell trafficking, immunoglobulin class switching and much, much more. The PI3Kd inhibitor idelalisib has recently been approved for the treatment of B cell lymphoma. Clinical trials of other PI3K inhibitors in autoimmune and inflammatory diseases are also in progress. This is an opportune time to consider a Research Topic considering when what we have learned about the PI3K signalling module in lymphocyte biology and how this is making an impact on clinical immunology and haematology.