Neuronal Chloride Transporters in Health and Disease

Neuronal Chloride Transporters in Health and Disease
Author: Xin Tang
Publsiher: Academic Press
Total Pages: 766
Release: 2020-06-19
ISBN 10: 0128153199
ISBN 13: 9780128153192
Language: EN, FR, DE, ES & NL

Neuronal Chloride Transporters in Health and Disease Book Review:

In the past several years, there has been an exciting body of new research that links impairments in the expression or function of neuronal chloride transporters to a growing number of diseases spanning from autism to brain aging. This book introduces the core concepts and highlights the recent advances in understanding the physiology and pathophysiology of the KCC and NKCC families of neuronal chloride transporters. Neuronal chloride transporter biology is reviewed, including roles in setting the transmembrane chloride gradient and the chloride transport-independent functions, such as regulating excitatory neurotransmission. Chapters are also dedicated to addressing the structure, post-translational modification, membrane trafficking, and protein interaction partners of neuronal chloride transporters, as well as the genetic and environmental factors that regulate their expression in neurons and the novel therapeutic approaches that target neuronal chloride transporters to treat neurological diseases. This new volume will provide readers with an up-to-date summary of the recent advances in neuronal chloride transporter research, with particular emphasis on some of the key emerging topics in the field. Summarizes roles of KCCs and NKCCs in regulating inhibitory and excitatory neurotransmission Reviews the molecular and cellular biology of neuronal chloride transporters Links neuronal chloride transporter deficiencies to autism, epilepsy, depression, and more Identifies role of transporter deficiencies in pain as well as brain and spinal cord injury Discusses drug research targeting neuronal chloride transporters for nervous system diseases

Physiology and Pathology of Chloride Transporters and Channels in the Nervous System

Physiology and Pathology of Chloride Transporters and Channels in the Nervous System
Author: F. Javier Alvarez-Leefmans,Eric Delpire
Publsiher: Academic Press
Total Pages: 630
Release: 2009-08-22
ISBN 10: 9780080922034
ISBN 13: 0080922031
Language: EN, FR, DE, ES & NL

Physiology and Pathology of Chloride Transporters and Channels in the Nervous System Book Review:

The importance of chloride ions in cell physiology has not been fully recognized until recently, in spite of the fact that chloride (Cl-), together with bicarbonate, is the most abundant free anion in animal cells, and performs or determines fundamental biological functions in all tissues. For many years it was thought that Cl- was distributed in thermodynamic equilibrium across the plasma membrane of most cells. Research carried out during the last couple of decades has led to a dramatic change in this simplistic view. We now know that most animal cells, neurons included, exhibit a non-equilibrium distribution of Cl- across their plasma membranes. Over the last 10 to 15 years, with the growth of molecular biology and the advent of new optical methods, an enormous amount of exciting new information has become available on the molecular structure and function of Cl- channels and carriers. In nerve cells, Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control. Disruption of Cl- homeostasis in neurons underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation. This book is about how chloride ions are regulated and how they cross the plasma membrane of neurons. It spans from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases. The first comprehensive book on the structure, molecular biology, cell physiology, and role in diseases of chloride transporters / channels in the nervous system in almost 20 years Chloride is the most abundant free anion in animal cells. THis book summarizes and integrates for the first time the important research of the past two decades that has shown that Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control The first book that systematically discusses the result of disruption of Cl- homeostasis in neurons which underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation Spanning topics from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases Involves all of the leading researchers in the field Includes an extensive introductory section that covers basic thermodynamic and kinetics aspects of Cl- transport, as well as current methods for studying Cl- regulation, spanning from fluorescent dyes in single cells to knock-out models to make the book available for a growing population of graduate students and postdocs entering the field

The olivo cerebellar system

The olivo cerebellar system
Author: Egidio D'Angelo,Elisa Galliano,Chris I De Zeeuw
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2016-04-29
ISBN 10: 288919826X
ISBN 13: 9782889198269
Language: EN, FR, DE, ES & NL

The olivo cerebellar system Book Review:

During the last decades, investigations on the olivo-cerebellar system have attained a high level of sophistication, which led to redefinitions of several structural and functional properties of neurons, synapses, connections and circuits. Research has expanded and deepened in so many directions and so many theories and models have been proposed that an ensemble review of the matter is now needed. Yet, hot topics remain open and scientific discussion is very lively at several fronts. One major question, here as well as in other major brain circuits, is how single neurons and synaptic properties emerge at the network level and contribute to behavioural regulation via neuronal plasticity. Other major aspects that this Research Topic covers and discusses include the development and circuit organization of the olivo-cerebellar network, the established and recent theories of learning and motor control, and the emerging role of the cerebellum in cognitive processing. By touching on such varied and encompassing subjects, this Frontiers Special Topic aims to highlight the state of the art and stimulate future research. We hope that this unique collection of high-quality articles from experts in the field will provide scientists with a powerful basis of knowledge and inspiration to enucleate the major issues deserving further attention.

GABA And Glutamate

GABA And Glutamate
Author: Janko Samardzic
Publsiher: BoD – Books on Demand
Total Pages: 138
Release: 2018-03-21
ISBN 10: 9535138219
ISBN 13: 9789535138211
Language: EN, FR, DE, ES & NL

GABA And Glutamate Book Review:

This book collates the contributions of a selected number of neuroscientists that are interested in the molecular, preclinical, and clinical aspects of neurotransmission research. The seven chapters in this book address the latest research/review data related to GABA/glutamate system's organization and function, the structure of receptors, subtypes and their ligands, as well as the translational approach and clinical implications. The book offers readers a rich collection of data regarding current and future applications of GABA and glutamate neurotransmission, including promising research strategies and potential clinical benefits.

Epithelial Anion Transport in Health and Disease

Epithelial Anion Transport in Health and Disease
Author: Derek J. Chadwick,Jamie A. Goode
Publsiher: John Wiley & Sons
Total Pages: 284
Release: 2006-07-11
ISBN 10: 0470029560
ISBN 13: 9780470029565
Language: EN, FR, DE, ES & NL

Epithelial Anion Transport in Health and Disease Book Review:

Cl- absorption and HCO3- secretion are intimately associated processes vital to epithelial function, itself a key physiological activity. Until recently the transporters responsible remained obscure, but a breakthrough occurred with the discovery of the SLC26 transporters family. It is now clear that the SLC26 transporters have broad physiological functions since mutations in several members are linked to a variety of diseases. This book describes the properties of this family in detail, with contributions from the leading global researchers in the field. Complementary views from experts on other ion channels are offered in the discussions, which make fascinating reading. This family consists of at least 10 genes, each of which has several splice variants. Most members of the family are expressed in the luminal membrane of epithelial cells. Characterization of anion transport by three members has revealed that all function as Cl-/HCO3- exchangers, suggesting that SLC26 transporters are responsible for the luminal Cl-/HCO3- exchange activity. The SLC26 transporters are activated by the CF transmembrane conductance regulator and activate it in turn, leading to a model in which these molecules act together to mediate epithelial Cl- absorption and HCO3- secretion. The book includes chapters on the transport of other molecules by the SLC26 family, including oxalate in the kidney and sugars in cochlear hair cells amongst others. It also describes recent discoveries that most SLC26 transporters bind to scaffold proteins and that they all contain a conserved domain predicted to participate in protein-protein interactions. These suggest the SLC26 transporters exist in complexes with other Cl- and HCO3- transporters, and possibly other regulatory proteins. This book explores the functional role of these interactions, leading to better understanding of transepithelial fluid and electrolyte secretion and the diseases associated with it.

Ion Channels in Health and Disease

Ion Channels in Health and Disease
Author: Geoffrey S. Pitt
Publsiher: Academic Press
Total Pages: 392
Release: 2016-10-04
ISBN 10: 0128020172
ISBN 13: 9780128020173
Language: EN, FR, DE, ES & NL

Ion Channels in Health and Disease Book Review:

Ion Channels in Health and Disease provides key insight to allow researchers to generate discoveries across disease states. A single resource that integrates disparate areas of biology and disease ion channel biology, this publication includes cross-referencing for disease, channels, and tissues. Offers a broad view of research of interest to early and experienced researchers across biological and biomedical research. Provides an overview of fundamental concepts in ion channels research to link defects in human disease Written in an accessible manner, without jargon Provides a helpful, easy cross-reference for diseases, channels, and tissues

Red Cell Membrane Transport in Health and Disease

Red Cell Membrane Transport in Health and Disease
Author: Ingolf Bernhardt,J. Clive Ellory
Publsiher: Springer Science & Business Media
Total Pages: 748
Release: 2013-04-17
ISBN 10: 3662051818
ISBN 13: 9783662051818
Language: EN, FR, DE, ES & NL

Red Cell Membrane Transport in Health and Disease Book Review:

51 worldwide leading experts in the field of erythrocyte research contributed to this first book on transport processes in red blood cells. It explains the latest findings on the basis of well-established principles, in an accessibly structured and carefully organized compilation.

Vitamin C in Health and Disease

Vitamin C in Health and Disease
Author: Anitra C. Carr,Jens Lykkesfeldt
Publsiher: MDPI
Total Pages: 298
Release: 2018-08-09
ISBN 10: 3038970298
ISBN 13: 9783038970293
Language: EN, FR, DE, ES & NL

Vitamin C in Health and Disease Book Review:

This book is a printed edition of the Special Issue "Vitamin C in Health and Disease" that was published in Nutrients

Waking and the Reticular Activating System in Health and Disease

Waking and the Reticular Activating System in Health and Disease
Author: Edgar Garcia-Rill
Publsiher: Academic Press
Total Pages: 330
Release: 2015-04-28
ISBN 10: 0128016329
ISBN 13: 9780128016329
Language: EN, FR, DE, ES & NL

Waking and the Reticular Activating System in Health and Disease Book Review:

Waking and the Reticular Activating System in Health and Disease provides a comprehensive overview on the “activating properties of the RAS. In health, the RAS provides the basis against which we assess the external world, and in disease it distorts that world and shatters our self-image. This book describes the physiology of each process, how it is disturbed in each disorder, and what the most appropriate treatment should be. Dr. Garcia-Rill, along with contributions from leading specialists, discusses the understanding of the RAS as a system not only modulating waking, but also in charge of survival mechanisms such as fight vs flight responses and reflexes. The full spectrum of these functions helps explain the complexity of symptoms evident in such disorders as disparate as schizophrenia and Parkinson’s disease. The book reviews the mechanisms that control waking and arousal, and especially how those mechanisms malfunction in certain neurological and psychiatric disorders. First comprehensive overview on the RAS and its role in schizophrenia, major depression, autism, Parkinson’s, Alzheimer’s, and other neurologic and mental diseases Offers a new way of thinking about brain function and the role of the RAS in our waking lives Written by a leading translational neuroscience researcher with contributions by specialists in the field

Neuromodulatory Control of Spinal Function in Health and Disease

Neuromodulatory Control of Spinal Function in Health and Disease
Author: Brian R. Noga,Shawn Hochman,Hans Hultborn
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2020-02-20
ISBN 10: 2889635171
ISBN 13: 9782889635177
Language: EN, FR, DE, ES & NL

Neuromodulatory Control of Spinal Function in Health and Disease Book Review:

Chlorine Compounds Advances in Research and Application 2011 Edition

Chlorine Compounds  Advances in Research and Application  2011 Edition
Author: Anonim
Publsiher: ScholarlyEditions
Total Pages: 203
Release: 2012-01-09
ISBN 10: 1464924414
ISBN 13: 9781464924415
Language: EN, FR, DE, ES & NL

Chlorine Compounds Advances in Research and Application 2011 Edition Book Review:

Chlorine Compounds: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Chlorine Compounds. The editors have built Chlorine Compounds: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Chlorine Compounds in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Chlorine Compounds: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Intestinal Water and Electrolyte Transport in Health and Disease

Intestinal Water and Electrolyte Transport in Health and Disease
Author: Mrinalin Rao,Jayashree Sarathy
Publsiher: Biota Publishing
Total Pages: 105
Release: 2012-01-12
ISBN 10: 1615041575
ISBN 13: 9781615041572
Language: EN, FR, DE, ES & NL

Intestinal Water and Electrolyte Transport in Health and Disease Book Review:

The unique architecture and physiology of the mammalian intestine, together with a tightly coordinated regulatory system, allows for the handling and absorption of as much as 9 L of fluid a day with 98% or greater efficiency. Advances in the past 40 years have made inroads into revealing the intricacies and interplay of numerous ion transporters and their modulators that are responsible for intestinal electrolyte and water transport. Studies of two devastating diseases, the virulent infectious disease cholera and the autosomal recessive disease cystic fibrosis, were largely responsible for this information explosion. These advances have been critical in the development of new therapeutic strategies to combat life-threatening diseases of varying etiologies ranging from enteric infections to cystic fibrosis and inflammatory bowel diseases. Yet, the story is far from complete, and progress needs to continue on translating information gained from reductionistic cell and tissue culture models, in vivo models, and ultimately human studies and on improving therapeutic approaches. This book reviews the current status of our knowledge of fluid transport across the intestine, including the complexities of transcellular and paracellular ion transport down the length of the intestine and how aberrations of normal physiological processes lead to disease. Table of Contents: Overview / Epithelial Cell and Tissue Architecture / Principles of Transepithelial Electrolyte and Water Movement / Intestinal Architecture and Electrolyte Transport / Electrolyte Transporters--Pumps, Carriers, and Channels / Water Transport / Regulation / Intestinal Disorders and Advances Toward Better Treatment of Intestinal Disorders / Conclusion / References

Issues in Neuroscience Research and Application 2011 Edition

Issues in Neuroscience Research and Application  2011 Edition
Author: Anonim
Publsiher: ScholarlyEditions
Total Pages: 3141
Release: 2012-01-09
ISBN 10: 1464963606
ISBN 13: 9781464963605
Language: EN, FR, DE, ES & NL

Issues in Neuroscience Research and Application 2011 Edition Book Review:

Issues in Neuroscience Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Neuroscience Research and Application. The editors have built Issues in Neuroscience Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Neuroscience Research and Application in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Neuroscience Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Retinal Pigment Epithelium in Health and Disease

Retinal Pigment Epithelium in Health and Disease
Author: Alexa Karina Klettner,Stefan Dithmar
Publsiher: Springer Nature
Total Pages: 357
Release: 2020-01-01
ISBN 10: 3030283844
ISBN 13: 9783030283841
Language: EN, FR, DE, ES & NL

Retinal Pigment Epithelium in Health and Disease Book Review:

This book provides a contemporary resource on one of the major players in retinal diseases – the Retinal Pigment Epithelium (RPE). Throughout the book, the physiological and the pathological function of the RPE are covered on equal terms, to help readers to understand the RPE as a whole. Moreover, the development of RPE in diagnostics and therapy are covered, as well as some practical knowledge about RPE experimental models. Retinal Pigment Epithelium in Health and Disease highlights new findings of RPE research and includes the state-of-the-art knowledge of each RPE topic presented. This important feature sets this book apart from other publications, with the chapters following a design which leads from the general to the specific, to give a precise collection of the facts known. The chapters are written by well-known experts that are currently active in the field as consultants, basic scientists, and group leaders, providing expert guidance on the current aspects and future outlooks of this topic.

Liver Regeneration and Carcinogenesis

Liver Regeneration and Carcinogenesis
Author: Gerard Meurant
Publsiher: Elsevier
Total Pages: 402
Release: 1995-09-27
ISBN 10: 9780080535548
ISBN 13: 0080535542
Language: EN, FR, DE, ES & NL

Liver Regeneration and Carcinogenesis Book Review:

Because of its marked capacity to regenerate and the ability of chemical carcinogens and viruses to ready transform hepatocytes, the liver has been used extensively as a model for investigating the molecular mechanisms of cellular proliferation and carcinogenesis. Recently, striking advances have occured in the understanding of hepatocyte growth regulation and the manner in which chemical agents and viruses alter these normal growth regulatory pathways in liver carcinogenesis. This explosion of information has occured in a multitude of researh disciplines. This book brings together current findings in a coherent manner, from a molecular point of view. Three sections cover in detail the areas of liver regeneration, liver carcinogenesis, and liver tumor therapy. The contributors are pioneers and leaders in this field. * Logical organization of material in three detailed and comprehensive sections: liver regeneration, liver carcinogenesis, and liver tumor treatment * Contributors are pioneers and leaders in the field * There are currently no books on this subject on the market * Research focus is at the molecular level

The Blood Brain Barrier in Health and Disease Volume One

The Blood Brain Barrier in Health and Disease  Volume One
Author: Katerina Dorovini-Zis
Publsiher: CRC Press
Total Pages: 426
Release: 2015-06-23
ISBN 10: 1498727069
ISBN 13: 9781498727068
Language: EN, FR, DE, ES & NL

The Blood Brain Barrier in Health and Disease Volume One Book Review:

Located at the interface between blood and the brain, the blood-brain barrier is a dynamic permeability barrier formed by a continuous layer of specialized endothelial cells endowed with important permeability, transport, and regulatory functions that both protect the internal milieu of the brain and allow essential nutrients to be transported into the brain. Over the last 25 years, we have witnessed remarkable expansion of our knowledge of the structure, biology, and function of the cerebral endothelium. In The Blood-Brain Barrier in Health and Disease, Volume 1, international experts discuss basic and new concepts and most recent advances pertaining to the development of the cerebral microvascular system. Subjects include the structure, function, permeability properties, transport mechanisms, and the inherent heterogeneity of the cerebral endothelium; the anatomy and physiological properties of the neurovascular unit; functional aspects of the choroid plexus; and important concepts and advances made over the last two decades that have shaped our understanding of the immunological function of the blood-brain barrier. This book is intended to serve as a valuable source of basic and advanced information for researchers, students, and clinicians interested in this fast-expanding field and stimulate further research well into the future.

Role of the Choroid Plexus in Health and Disease

Role of the Choroid Plexus in Health and Disease
Author: Jeppe Praetorius,Bonnie Blazer-Yost,Helle Damkier
Publsiher: Springer Nature
Total Pages: 287
Release: 2020-04-17
ISBN 10: 1071605364
ISBN 13: 9781071605363
Language: EN, FR, DE, ES & NL

Role of the Choroid Plexus in Health and Disease Book Review:

This book highlights the importance of the choroid plexus, which forms the blood-cerebrospinal fluid barrier and is the site of the major production of the cerebrospinal fluid (CSF). The authors show that this barrier is crucial for maintaining important compositional differences between the blood plasma and the CSF. The choroid plexus epithelial cells also prevent the spread of infectious agents and other blood-borne entities to the brain tissue. Chapter topics range from the production of CSF by electrolyte regulation in the choroid plexus, to details on the selectively transporting nature of this barrier. Further, the authors elaborate on the important roles of CSF in sustaining brain health by providing hydration, solutes, and nutrients to the brain tissue. Readers will also learn how CSF circulates signaling molecules within the compartments of the brain and removes waste products from the brain tissue. Elucidating the regulation of these processes in the choroid plexus is not only important for the readers’ understanding of normal brain development and function, but is also crucial for resolving a variety of cerebral challenges that lead to brain edema, as well as developing treatments for diseases. The book discusses disease models like hydrocephalus, sleep disorders, and age-related dementia. Its comprehensive coverage makes this volume a valuable resource for researchers in cell and neurophysiology, as well as graduate students of the neurosciences.

Diversity and Functions of GABA Receptors A Tribute to Hanns M hler Part A

Diversity and Functions of GABA Receptors  A Tribute to Hanns M  hler  Part A
Author: Anonim
Publsiher: Academic Press
Total Pages: 282
Release: 2015-01-12
ISBN 10: 0128026928
ISBN 13: 9780128026922
Language: EN, FR, DE, ES & NL

Diversity and Functions of GABA Receptors A Tribute to Hanns M hler Part A Book Review:

This new volume of Advances in Pharmacology presents the diversity and functions of GABA Receptors. The volume looks at research performed in the past 20 years which has revealed specific physiological and pharmacological functions of individual GABAA receptor subtypes, providing novel opportunities for drug development. Contributions from the best authors in the field An essential resource for pharmacologists, immunologists, and biochemists

GABA signaling in health and disease

GABA signaling in health and disease
Author: Yehezkel Ben-Ari
Publsiher: Frontiers E-books
Total Pages: 135
Release: 2021
ISBN 10: 2889190846
ISBN 13: 9782889190843
Language: EN, FR, DE, ES & NL

GABA signaling in health and disease Book Review:

GABAergic neurons provide most of the inhibitory drive of adult networks and play major roles in the integrative properties of brain networks. Alterations of GABAergic signals are associated with major neurological disorders and GABA mimetic drugs are widely used as comfort molecules and to treat several brain disorders. Thus, the inhibitory drive is altered in epilepsies, infantile developmentally related disorders but also Parkinson disease, and anoxo-ischemic insults to just name a few. From the developmental stand point, GABAergic neurons mature before principal neurons and provide an important source of early activities and are thus instrumental in activity dependent modulation of the construction of cortical functional units. The goal of this Research Topic is to bring together experts studying GABA signals at the molecular, cellular and network levels in physiological and pathological conditions and to examine the fate of GABA signals along transversal ideas linking these diverse domains. A particular emphasis is brain maturation as it is now clear that alteration of developmental sequences -notably of GABA signals- impairs brain development leading to life long deleterious neurological sequels. While this Frontiers Research Topic originated as a repository of work presented at CNCR Amsterdam, papers are invited from researchers continuing to work on this topic as the field expands.

Ion Channels and Transporters of Epithelia in Health and Disease

Ion Channels and Transporters of Epithelia in Health and Disease
Author: Kirk L. Hamilton,Daniel C Devor
Publsiher: Springer
Total Pages: 1019
Release: 2015-12-14
ISBN 10: 1493933663
ISBN 13: 9781493933662
Language: EN, FR, DE, ES & NL

Ion Channels and Transporters of Epithelia in Health and Disease Book Review:

This book sheds new light on the physiology, molecular biology and pathophysiology of epithelial ion channels and transporters. It combines the basic cellular models and functions by means of a compelling clinical perspective, addressing aspects from the laboratory bench to the bedside. The individual chapters, written by leading scientists and clinicians, explore specific ion channels and transporters located in the epithelial tissues of the kidney, intestine, pancreas and respiratory tract, all of which play a crucial part in maintaining homeostasis. Further topics include the fundamentals of epithelial transport; mathematical modeling of ion transport; cell volume regulation; membrane protein folding and trafficking; transepithelial transport functions; and lastly, a discussion of transport proteins as potential pharmacological targets with a focus on the pharmacology of potassium channels.