Neural Stem Cells and Adult Neurogenesis

Neural Stem Cells and Adult Neurogenesis
Author: Arie S. Mobley
Publsiher: Academic Press
Total Pages: 375
Release: 2019-03-15
ISBN 10: 0128110147
ISBN 13: 9780128110140
Language: EN, FR, DE, ES & NL

Neural Stem Cells and Adult Neurogenesis Book Review:

Neural Stem Cells and Adult Neurogenesis provides graduate students and neuroscientists with a basic understanding of what neural stem cells are and the cell types they produce. This early graduate level reference describes their physiology and potential for medicine and provides students with fundamental stem cell information. An overview of stem cell sources in the human body and a brief mention of relevant diseases provide context for the value of this knowledge. The book also includes chapters on induced pluripotent stem cells (iPSCs), the methods used to obtain them, and a review of the ethical challenges associated with stem cell research. For each region, the book provides a description of its neurogenic niche, cellular and molecular biology, and information on the neurons' contribution to normal and diseased brain function. The level of information is appropriate for early graduate students, introducing technology and molecular biology in an accessible format. Provides a basic understanding of what a stem cell is, the different types, and their potential in health and research Details adult neurogenesis and its role in behavior, stroke and disease Includes walkthrough and technology boxes that illustrate experimental concepts, new approaches and techniques

Adult Neurogenesis

Adult Neurogenesis
Author: Gerd Kempermann
Publsiher: Oxford University Press, USA
Total Pages: 426
Release: 2006
ISBN 10: 9780195179712
ISBN 13: 0195179714
Language: EN, FR, DE, ES & NL

Adult Neurogenesis Book Review:

The discovery of adult neurogenesis and of stem cells in the brain has changed our view of the mature brain. Though we now know that the adult brain can make new neurons, it normally does so only in two privileged regions, the olfactory bulb and the hippocampus. Yet stem cells, which have the potential to produce new neurons, can be found throughout the adult brain. So why does the brain not make wider use of its potential for neurogenesis? And what is the function of new neurons and of neural stem cells in areas where they occur? After all, the brain regenerates poorly and many neurological and psychiatric disorders are chronic because cell replacement has not taken place. This is the first comprehensive, integrated account of one of the most exciting areas of neuroscience. It begins with the historical background and discusses theories of adult neurogenesis and neural stem cell biology in the context of learning and memory processes as well as structural plasticity. It describes in detail neurogenesis in the adult hippocampus and olfactory system and then surveys the regulatory, functional, and comparative aspects, concluding with a chapter on the provocative hypotheses that link failing adult neurogenesis with such diseases as temporal lobe epilepsy, major depression, brain tumors, and dementias. For graduate students, investigators, and clinicians in the neurosciences, developmental biology, and stem cell research, this book is a unique resource that sifts through the evidence for exciting scientific ideas and fosters a realistic view of the therapeutic possibilities for the use of stem cells in the adult brain.

Adult Neurogenesis and Neural Stem Cells in Mammals

Adult Neurogenesis and Neural Stem Cells in Mammals
Author: Philippe Taupin
Publsiher: Nova Publishers
Total Pages: 208
Release: 2006
ISBN 10: 9781594548567
ISBN 13: 1594548560
Language: EN, FR, DE, ES & NL

Adult Neurogenesis and Neural Stem Cells in Mammals Book Review:

This title contains a book and CD. The brain has a number of nerve cells estimated at a magnitude of 10 to 100 billion, and 1014 to 1015 synapses, and therefore is the most complex organ of the human body. During fetal development the foundations of the brain are laid as billions of neurons form appropriate connections and patterns. In the adult mammalian brain, most neurons are post-mitotic, and therefore at risk for irreversible damage. As we age, atrophy of the brain occurs. As brain weight declines the volume of the brain in the 8th decade is reduced by 6 per cent -10 per cent versus the third decade, and neuronal loss occurs, up to 10,000 to 100,000 neurons are lost per day, though this estimation is being revised downward with the advance of more sophisticated measurements.

Adult Neurogenesis in the Hippocampus

Adult Neurogenesis in the Hippocampus
Author: Juan J. Canales
Publsiher: Academic Press
Total Pages: 298
Release: 2016-05-23
ISBN 10: 0128019921
ISBN 13: 9780128019924
Language: EN, FR, DE, ES & NL

Adult Neurogenesis in the Hippocampus Book Review:

Neurogenesis in the adult brain has emerged as one of the most dynamic and rapidly moving fields in modern neuroscience research. The implications of adult neurogenesis for health and well-being are wide-ranging, with findings in this area having distinct relevance for treatment and rehabilitation in neurology and psychopathology. Adult Neurogenesis in the Hippocampus addresses these implications by providing an up-to-date account on how neurogenesis in the adult hippocampus contributes to critical psychological and physiological processes, such as learning and memory, and how it is modified by life experiences, such as aging, environmental enrichment, exercise, and dieting. The book also provides the most current reviews of how adult hippocampal neurogenesis influences the pathogenesis of mood disorders, addiction, and key neurological disorders. This book is the ideal resource for researchers and advanced graduates seeking focused knowledge on the role of adult neurogenesis in brain health and disease. Provides a unique overview of how adult hippocampal neurogenesis contributes to adaptive processes, brain psychopathology, and disease Includes state-of-the-art reviews by leading world experts in adult neurogenesis

Exam Prep for Neural Stem Cells and Adult Neurogenesis

Exam Prep for  Neural Stem Cells and Adult Neurogenesis
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 2021
ISBN 10:
ISBN 13:
Language: EN, FR, DE, ES & NL

Exam Prep for Neural Stem Cells and Adult Neurogenesis Book Review:

Neurogenesis in the Adult Brain I

Neurogenesis in the Adult Brain I
Author: Tatsunori Seki,Kazunobu Sawamoto,Jack M. Parent,Arturo Alvarez-Buylla
Publsiher: Springer Science & Business Media
Total Pages: 413
Release: 2011-06-15
ISBN 10: 9784431539339
ISBN 13: 4431539336
Language: EN, FR, DE, ES & NL

Neurogenesis in the Adult Brain I Book Review:

The discovery of adult neurogenesis caused a paradigm shift in the neurosciences. For more than 100 years, it was believed that adult neurons do not regenerate. Joseph Altman and Fernando Nottebohm found proof to the contrary and changed the course of history. Their research, included here, provides the foundations of the field. Today, adult neurogenesis is a rapidly expanding discipline applicable to the study of brain development and diseases, learning and memory, aging, and neuropsychiatric disorders. With multiple authors, the 27 chapters of this book contain the latest work in two volumes. The first presents the basic biology of adult neurogenesis in non-mammalian vertebrates and in the mammalian hippocampus and olfactory bulb, and the second discusses clinical implications and delves into adult neurogenesis and brain injury as well as neurodegenerative and neuropsychiatric pathologies. With details of the anatomy, physiology, and molecular biology of the two neurogenic brain regions, this book provides indispensable knowledge for many areas of neuroscience and for experimental and clinical applications of adult neurogenesis to brain therapy.

The Neurobiology of Olfaction

The Neurobiology of Olfaction
Author: Anna Menini
Publsiher: CRC Press
Total Pages: 448
Release: 2009-11-24
ISBN 10: 9781420071993
ISBN 13: 1420071998
Language: EN, FR, DE, ES & NL

The Neurobiology of Olfaction Book Review:

Comprehensive Overview of Advances in Olfaction The common belief is that human smell perception is much reduced compared with other mammals, so that whatever abilities are uncovered and investigated in animal research would have little significance for humans. However, new evidence from a variety of sources indicates this traditional view is likely overly simplistic. The Neurobiology of Olfaction provides a thorough analysis of the state-of-the-science in olfactory knowledge and research, reflecting the growing interest in the field. Authors from some of the most respected laboratories in the world explore various aspects of olfaction, including genetics, behavior, olfactory systems, odorant receptors, odor coding, and cortical activity. Until recently, almost all animal research in olfaction was carried out on orthonasal olfaction (inhalation). It is only in recent years, especially in human flavor research, that evidence has begun to be obtained regarding the importance of retronasal olfaction (exhalation). These studies are beginning to demonstrate that retronasal smell plays a large role to play in human behavior. Highlighting common principles among various species – including humans, insects, Xenopus laevis (African frog), and Caenorhabditis elegans (nematodes) – this highly interdisciplinary book contains chapters about the most recent discoveries in odor coding from the olfactory epithelium to cortical centers. It also covers neurogenesis in the olfactory epithelium and olfactory bulb. Each subject-specific chapter is written by a top researcher in the field and provides an extensive list of reviews and original articles for students and scientists interested in further readings.

Neural Stem Cells in Health and Disease

Neural Stem Cells in Health and Disease
Author: Ashok K Shetty
Publsiher: World Scientific Publishing Company
Total Pages: 572
Release: 2015-08-28
ISBN 10: 9814623199
ISBN 13: 9789814623193
Language: EN, FR, DE, ES & NL

Neural Stem Cells in Health and Disease Book Review:

This book is a comprehensive guide on neural stem cell behavior in health and disease. The book confers the altered behavior of endogenous neural stem cells in neurodegenerative disease conditions and the prospects of neural stem cell therapy for alleviating brain dysfunction in a variety of neurodegenerative disorders. Neural stem cell activity and neurogenesis in the adult brain is now confirmed in virtually all mammalian species including humans. Hence, a series of chapters in the first half of the book discusses the current knowledge on mechanisms of neural stem cell activity, the extent and functional significance of neurogenesis in the adult brain under normal, aged and disease environments, the susceptibility of neural stem cells and the plasticity of neurogenesis to alcohol, drugs of abuse and anesthetic agents, and advanced techniques that trigger neurogenesis in non-neurogenic regions. A second series of chapters in this book are focused on discussing the promise and efficacy of grafting of neural stem cells and/or other stem cells for treating neurological disorders such as Parkinson's disease, stroke, temporal lobe epilepsy, Alzheimer's disease and spinal cord injury. The final chapter confers on advances that are made in manufacturing a variety of neural cell types from human pluripotent stem cells that can be used as donor cells for cell transplantation.

Adult Neurogenesis 2

Adult Neurogenesis 2
Author: Gerd Kempermann, MD
Publsiher: OUP USA
Total Pages: 668
Release: 2011-02-17
ISBN 10: 9780199729692
ISBN 13: 0199729697
Language: EN, FR, DE, ES & NL

Adult Neurogenesis 2 Book Review:

The second edition Adult Neurogenesis 2 gives a comprehensive overview on this exciting and rapidly evolving topic. It includes research on adult neurogenesis, the generation of new neurons in the adult brain, changes how we look at neuropsychiatric disorders such as dementias and major depression as well as normal cognitive aging.

Stem Cells and Regenerative Medicine

Stem Cells and Regenerative Medicine
Author: Philippe Taupin
Publsiher: Nova Publishers
Total Pages: 164
Release: 2008
ISBN 10: 9781604564723
ISBN 13: 1604564725
Language: EN, FR, DE, ES & NL

Stem Cells and Regenerative Medicine Book Review:

The subject of this book is stem cell research and regenerative medicine. Stem cells are undifferentiated cells that have the ability to differentiate into different lineages of the body. Stem cells carry tremendous potential for the treatment of a broad range of disease and injuries. Stem cells exist in embryonic, fetal, and adult tissues, including the adult central nervous system. This book aims at, in depth, the recent developments in stem cell research and regenerative medicine. Though this book encompasses all the fields of stem cell research and regenerative medicine, it emphasises adult neurogenesis and neural stem cell research and therapy.

Adult Stem Cell Niches

Adult Stem Cell Niches
Author: Sabine Wislet
Publsiher: BoD – Books on Demand
Total Pages: 330
Release: 2014-08-01
ISBN 10: 9535117181
ISBN 13: 9789535117186
Language: EN, FR, DE, ES & NL

Adult Stem Cell Niches Book Review:

Tissue-specific stem cells have the capacity to self-renew and differentiate into several types of functional cells that replenish lost cells throughout an organism?s lifetime. Studies on stem cells from diverse systems have shown that stem cell function is controlled by extracellular cues from the niche and by intrinsic genetic programs within the stem cell. The objectives of this book would be to review the molecular mechanisms that mediate the balanced response of stem cells to the needs of the organisms. Likewise, niches have also been linked to pathologies, by imposing aberrant function on stem cells or other targets. Therefore, the second objective of this book would be to highligh the molecular dysregulation of niche biology leading to the disease. The third objective would be to review the therapeutical targets described within stem cell niches.

Neuroimmune Pharmacology

Neuroimmune Pharmacology
Author: Tsuneya Ikezu,Howard E. Gendelman
Publsiher: Springer
Total Pages: 1035
Release: 2016-12-22
ISBN 10: 3319440225
ISBN 13: 9783319440224
Language: EN, FR, DE, ES & NL

Neuroimmune Pharmacology Book Review:

The second edition of Neuroimmune Pharmacology bridges the disciplines of neuroscience, immunology and pharmacology from the molecular to clinical levels with particular thought made to engage new research directives and clinical modalities. Bringing together the foremost field authorities from around the world, Neuroimmune Pharmacology will serve as an invaluable resource for the basic and applied scientists of the current decade and beyond.

Jasper s Basic Mechanisms of the Epilepsies

Jasper s Basic Mechanisms of the Epilepsies
Author: Jeffrey Noebels,Massimo Avoli,Michael Rogawski,Richard Olsen,Antonio Delgado-Escueta
Publsiher: Oxford University Press
Total Pages: 1264
Release: 2012-06-01
ISBN 10: 0199842590
ISBN 13: 9780199842599
Language: EN, FR, DE, ES & NL

Jasper s Basic Mechanisms of the Epilepsies Book Review:

H.H. Jasper, A.A. Ward, A. Pope and H.H. Merritt, chair of the Public Health Service Advisory Committee on the Epilepsies, National Institutes of Health, published the first volume on Basic Mechanisms of the Epilepsies (BME) in 1969. Their ultimate goal was to search for a "better understanding of the epilepsies and seek more rational methods of their prevention and treatment." Since then, basic and clinical researchers in epilepsy have gathered together every decade and a half with these goals in mind -- assessing where epilepsy research has been, what it has accomplished, and where it should go. In 1999, the third volume of BME was named in honor of H.H. Jasper. In line with the enormous expansion in the understanding of basic epilepsy mechanisms over the past four decades, this fourth edition of Jasper's BME is the most ambitious yet. In 90 chapters, the book considers the role of interactions between neurons, synapses, and glia in the initiation, spread and arrest of seizures. It examines mechanisms of excitability, synchronization, seizure susceptibility, and ultimately epileptogenesis. It provides a framework for expanding the epilepsy genome and understanding the complex heredity responsible for common epilepsies as it explores disease mechanisms of ion channelopathies and developmental epilepsy genes. It considers the mechanisms of conditions of epilepsy comorbidities. And, for the first time, this 4th edition describes the current efforts to translate the discoveries in epilepsy disease mechanisms into new therapeutic strategies. This book, considered the 'bible' of basic epilepsy research, is essential for the student, the clinician scientist and all research scientists who conduct laboratory-based experimental epilepsy research using cellular, brain slice and animal models, as well as for those interested in related disciplines of neuronal oscillations, network plasticity, and signaling in brain strucutres that include the cortex, hippocampus, and thalamus. In keeping with the 1969 goals, the book is now of practical importance to the clinical neurologist and epileptologist as the progress of research in molecular genetics and modern efforts to design antiepileptic drugs, cures and repairs in the epilepsies converge and impact clinical care.

The ventricular subventricular zone a source of oligodendrocytes in the adult brain

The ventricular subventricular zone  a source of oligodendrocytes in the adult brain
Author: Oscar Gonzalez-Perez,Jose Manuel Garcia-Verdugo,Adan Aguirre
Publsiher: Frontiers E-books
Total Pages: 329
Release: 2014-09-30
ISBN 10: 2889192687
ISBN 13: 9782889192687
Language: EN, FR, DE, ES & NL

The ventricular subventricular zone a source of oligodendrocytes in the adult brain Book Review:

Demyelinating diseases are characterized by an extensive loss of oligodendrocytes and myelin sheaths from axolemma, which commonly result in disability in young adults. To date, there is no effective treatment against these neurological disorders. In the adult brain, there are neural stem cells (NSCs) that reside within a niche denominated ventricular-subventricular zone (V-SVZ) in the lateral wall of the cerebral ventricles. NSCs give rise to neurons and oligodendrocytes that help preserve cellular homeostasis. Growing evidence indicates that V-SVZ progenitor cells may represent an endogenous source of oligodendrocytes that can be useful to treat demyelinating diseases. This e-Book “The ventricular-subventricular zone as a source of oligodendrocytes in the adult brain” collected the most recent evidence regarding the mechanisms that modulate the proliferation, migration, quiescence, cell-fate choices and survival of oligodendrocyte precursors generated in the V-SVZ. Herein, we compiled information about the role of Sonic hedgehog, NMDA receptors, ErbB proteins, hemopressin, erythropoietin, osmolarity and microglia in the oligodendrocyte production. Some chapters also describe the role of oligodendrocyte precursors in the preservation of cellular homeostasis, aging and white matter repair. All these information is presented as novel research findings, short communications, and review articles, which were written by experts in the field of oligodendrocyte generation, myelin production and white matter re-myelination.

Hippocampal Development

Hippocampal Development
Author: Samuel J. Pleasure
Publsiher: S. Karger AG (Switzerland)
Total Pages: 201
Release: 2006
ISBN 10: 9783805581929
ISBN 13: 3805581920
Language: EN, FR, DE, ES & NL

Hippocampal Development Book Review:

The hippocampal formation plays a critical role in navigation and memory under normal conditions. In pathologies such as Alzheimer's disease and epilepsy, the hippocampus represents one of the first brain regions to suffer damage. When hippocampal development is abnormal, pathological conditions featuring cognitive dysfunction and seizures are common, particularly in children. This publication summarizes new data and relevant findings to a critical understanding of hippocampal development - from anatomy to physiology and from rodents to human. It provides original articles on developmental pathology and on the ongoing role of developmental signaling systems in adults. Broadly, the topics include processes involved in the development of normal or abnormal hippocampus and pathological implications associated with normal or abnormal development, and neurogenesis in an immature or adult hippocampus. Presenting a wide-ranging collection of contributions on hippocampal development, this issue will be of great value for neurobiologists, neurologists, psychiatrists and pediatricians.

The Hippocampus

The Hippocampus
Author: Ales Stuchlik
Publsiher: BoD – Books on Demand
Total Pages: 178
Release: 2018-07-11
ISBN 10: 1789233569
ISBN 13: 9781789233568
Language: EN, FR, DE, ES & NL

The Hippocampus Book Review:

The hippocampus is an important brain region, a true central hub for memory of various kinds and other processes. Neuropsychiatric disorders such as Alzheimer's disease, drug addiction, and schizophrenia are characterized by hippocampal alterations. The dentate gyrus of the hippocampus is a site exhibiting adult neurogenesis. This book covers the topic of the hippocampus from various perspectives. It discusses adult neurogenesis, effect of enriched environments on hippocampal plasticity, and long-term potentiation-associated gene expression. The book also addresses multiscale representations of complex environments and strategies in the hippocampus-dependent spatial tasks. Finally, insight into the hippocampus as a link between negative affect and relapse to psychostimulants is provided. The book collects evidence of various hippocampal functions in healthy and disordered brain.

Neurogenesis and Neural Plasticity

Neurogenesis and Neural Plasticity
Author: Catherine Belzung,Peter Wigmore
Publsiher: Springer Science & Business Media
Total Pages: 401
Release: 2014-07-08
ISBN 10: 364236232X
ISBN 13: 9783642362323
Language: EN, FR, DE, ES & NL

Neurogenesis and Neural Plasticity Book Review:

This volume brings together authors working on a wide range of topics to provide an up to date account of the underlying mechanisms and functions of neurogenesis and synaptogenesis in the adult brain. With an increasing understanding of the role of neurogenesis and synaptogenesis it is possible to envisage improvements or novel treatments for a number of diseases and the possibility of harnessing these phenomena to reduce the impact of ageing and to provide mechanisms to repair the brain.

Perspectives of Stem Cells

Perspectives of Stem Cells
Author: Henning Ulrich
Publsiher: Springer Science & Business Media
Total Pages: 290
Release: 2010-01-14
ISBN 10: 9789048133758
ISBN 13: 9048133750
Language: EN, FR, DE, ES & NL

Perspectives of Stem Cells Book Review:

Stem cells are fascinating cell types. They can replicate themselves forever while retaining the potential to generate progeny with speci?c functions. Because of these special properties, stem cells have been subjects of intensive investigation, from understanding basic mechanisms underlying tissue generation, to modeling human diseases, to application for cell replacement therapy. Stem cells come in different forms. For example, mouse embryonic stem cells can general all cell types in a body, either in a dish or when put back into mouse embryos. On the other hand, neural stem cells in the adult brain generate neurons and glia cells that contribute to the brain’s plasticity. Rapid progress has been made in the stem cell ?eld with discov- ies published in a record speed. A quick Pubmed search has returned 2789 hits for “embryonic stem cells” and 815 hits for “adult neural stem cells/neurogenesis” in the year 2008 alone. It remains a taunting task for all who are interested in stem cells to keep up with rapidly accumulating literatures. The “Perspectives of Stem Cells” by a truly international team of experts provides a timely and invaluable highlight of the stem cell ?eld gearing toward future therapeutic applications in the nervous system. Stem cells with neural potentials have attracted a lot of attention because of their promise for cell replacement therapy, ranging from degenerative neurological dis- ders to spinal cord injuries.

Stem Cells in Birth Defects Research and Developmental Toxicology

Stem Cells in Birth Defects Research and Developmental Toxicology
Author: Theodore P. Rasmussen
Publsiher: John Wiley & Sons
Total Pages: 368
Release: 2018-03-27
ISBN 10: 1119283221
ISBN 13: 9781119283225
Language: EN, FR, DE, ES & NL

Stem Cells in Birth Defects Research and Developmental Toxicology Book Review:

This book contains material contributed by forward-looking scientists who work at the interface of stem cell research and applied science with the aim to improve human fetal safety and the understanding of human developmental and degenerative disorders. Provides important platforms and contemporary accounts of the state of stem cell research in the fields of toxicology and teratology Considers both in vitro uses of stem cells as platforms for teratology and also stem cellopathies, which are in vivo developmental and degenerative disorders Helps the pharmaceutical industry and safety and environmental authorities validate the status quo of in vitro toxicity test systems based on human pluripotent stem cells and their derivatives

The Cell Cycle in the Central Nervous System

The Cell Cycle in the Central Nervous System
Author: Damir Janigro
Publsiher: Springer Science & Business Media
Total Pages: 563
Release: 2008-01-23
ISBN 10: 9781597450218
ISBN 13: 1597450219
Language: EN, FR, DE, ES & NL

The Cell Cycle in the Central Nervous System Book Review:

Cell Cycle in the Central Nervous System overviews the changes in cell cycle as they relate to prenatal and post natal brain development, progression to neurological disease or tumor formation.Topics covered range from the cell cycle during the prenatal development of the mammalian central nervous system to future directions in postnatal neurogenesis through gene transfer, electrical stimulation, and stem cell introduction. Additional chapters examine the postnatal development of neurons and glia, the regulation of cell cycle in glia, and how that regulation may fail in pretumor conditions or following a nonneoplastic CNS response to injury. Highlights include treatments of the effects of deep brain stimulation on brain development and repair; the connection between the electrophysiological properties of neuroglia, cell cycle, and tumor progression; and the varied immunological responses and their regulation by cell cycle.