NETosis At the Intersection of Cell Biology Microbiology and Immunology

NETosis  At the Intersection of Cell Biology  Microbiology  and Immunology
Author: Mariana J. Kaplan,Marko Radic
Publsiher: Frontiers E-books
Total Pages: 329
Release: 2013-08-08
ISBN 10: 2889191583
ISBN 13: 9782889191581
Language: EN, FR, DE, ES & NL

NETosis At the Intersection of Cell Biology Microbiology and Immunology Book Review:

NETosis is a unique form of cell death that is characterized by the release of decondensed chromatin and granular contents to the extracellular space. The initial observation of NETosis placed the process within the context of the innate immune response to infections. Neutrophils, the most numerous leukocytes that arrive quickly at the site of an infection, were the first cell type shown to undergo extracellular trap formation. However, subsequent studies showed that other granulocytes are also capable of releasing nuclear chromatin following stimulation. The extracellular chromatin acts to immobilize microbes and prevent their dispersal in the host. Bacterial breakdown products and inflammatory stimuli induce NETosis and the release of NETs requires enzyme activities. Histones in NET chromatin become modified by peptidylarginine deiminase 4 (PAD4) and cleaved at specific sites by proteases. NETs serve for attachment of bactericidal enzymes including myeloperoxidase, leukocyte proteases, and the cathelicidin LL-37. While the benefit of NETs in an infection appears clear, NETs also figure prominently at the center of various pathologic states. Therefore, it is important for NETs to be efficiently cleared; else digestive enzymes may gain access to tissues where inflammation takes place. Persistent NET exposure at sites of inflammation may lead to a further complication: NET antigens may provoke acquired immune responses and, over time, could initiate autoimmune reactions. Recent studies identified aberrant NET synthesis and/or clearance in inflammatory/autoimmune conditions such as systemic lupus erythematosus (SLE), psoriasis, ANCA-positive vasculitis, gout and Felty’s syndrome. In the case of SLE, for example, it appears that LL-37 exposed in the NETs may be a significant trigger of type I Interferon responses in this disease. Recent evidence also implicates aberrant NET formation in the development of endothelial damage, atherosclerosis and thrombosis. NETosis is thus of interest to researchers who investigate innate immune responses, host-pathogen interactions, chronic inflammatory disorders, cell and vascular biology, biochemistry, and autoimmunity. As we approach the 10-year-anniversary of the initial discovery of NETosis, it is useful and timely to review the so far identified mechanisms and pathways of NET formation, their role in bacterial and fungal defense and their putative importance as inducers of autoimmune responses. We look forward to a rich and rigorous discussion of these and related issues that benefit from interdisciplinary approaches, collaborations and exciting discoveries.

NETosis

NETosis
Author: Geeta Rai
Publsiher: Academic Press
Total Pages: 200
Release: 2019-06-01
ISBN 10: 0128163798
ISBN 13: 9780128163795
Language: EN, FR, DE, ES & NL

NETosis Book Review:

NETosis: Immunity, Pathogenesis and Therapeutics takes a focused approach to the clinical aspects of NETosis and drug development, bringing critical findings. Chapters introduce NETosis, consider mechanisms and antimicrobial strategies regulating NETosis, examine NETosis in neonates, explore the role of NETosis in autoimmunity, delve into NETosis and other diseases, and present therapeutic approaches for dysregulated NETosis. Since Brinkamm, et al, discovered an unrecognized neutrophil anti-microbial mechanism responsible for the extracellular killing of invading pathogens in 2004, the novel process in which nuclear chromatin de-condenses and DNA is ejected into the extra cellular environment, trapping and inactivating tissue pathogens has rapidly evolved. Presents an up-to-date and detailed analysis of NETosis Brings together critical findings on NETosis as a comparatively novel immune mechanism Focuses on the clinical aspects of NETosis that lead to drug development Covers the topic with a cogency and passion that is based on years of scientific research

NETosis 2 The Excitement Continues

NETosis 2  The Excitement Continues
Author: Mariana J. Kaplan,Marko Radic,Martin Herrmann
Publsiher: Frontiers Media SA
Total Pages: 329
Release: 2017-12-28
ISBN 10: 2889453790
ISBN 13: 9782889453795
Language: EN, FR, DE, ES & NL

NETosis 2 The Excitement Continues Book Review:

NETosis, a form of cell death that manifests by the release of decondensed chromatin to the extracellular space, provides valuable insights into mechanisms and consequences of cellular demise. Because extracellular chromatin can immobilize microbes, the extended nucleohistone network was called a neutrophil extracellular trap (NET), and the process of chromatin release was proposed to serve an innate immune defense function. Extracellular chromatin NETs were initially observed in studies of neutrophils and are most prominent in these types of granulocytes. Subsequent studies showed that other granulocytes and, in a limited way, other cells of the innate immune response may also release nuclear chromatin following certain kinds of stimulation. Variations of NETosis were noted with cells that remain temporarily motile after the release of chromatin. Numerous stimuli for NETosis were discovered, including bacterial breakdown products, inflammatory stimuli, particulate matter, certain crystals, immune complexes and activated thrombocytes. Fundamental explorations into the mechanisms of NETosis observed that neutrophil enzyme activity (PAD4, neutrophil elastase, proteinase 3 and myeloperoxidase) and signal transduction pathways contribute to the regulation of NETosis. Histones in NET chromatin become modified by peptidylarginine deiminase 4 (PAD4) and cleaved at specific sites by proteases, leading to extensive chromatin externalization. In addition, NETs serve for attachment of bactericidal enzymes including myeloperoxidase, leukocyte proteases, and the cathelicidin LL-37. NETs are decorated with proteases and may thus contribute to tissue destruction. However, the attachment of these enzymes to NET-associated supramolecular structures restricts systemic spread of the proteolytic activity. While the benefit of NETs in an infection appears obvious, NETs also participate as key protagonists in various pathologic states. Therefore, it is essential for NETs to be efficiently cleared; otherwise digestive enzymes may gain access to tissues where inflammation takes place. Persistent NET exposure at sites of inflammation may lead to a further complication: NET antigens may provoke acquired immune responses and, over time, could initiate autoimmune reactions, serve as antigen for nuclear autoantibodies and foster DNA immune complex-related inflammation. Neutrophil products and deiminated proteins comprise an important group of autoantigens in musculoskeletal disorders. Aberrant NET synthesis and/or clearance are often associated with inflammatory and autoimmune conditions. Recent evidence also implicates aberrant NET formation in the development of endothelial damage, atherosclerosis and thrombosis. Intravital microscopy provides evidence for conditions that induce NETosis in vivo. Furthermore, NETs can easily be detected in synovial fluid and tissue sections of patients with arthritis and gout. NETosis is thus of interest to researchers who investigate innate immune responses, host-pathogen interactions, chronic inflammatory disorders, cell and vascular biology, biochemistry, and autoimmunity. As we enter the second decade of research on NETosis, it is useful and timely to review the mechanisms and pathways of NET formation, their role in bacterial and fungal defense and their importance as inducers of autoimmune responses.

Oxford Textbook of Rheumatoid Arthritis

Oxford Textbook of Rheumatoid Arthritis
Author: David L. Scott,James Galloway,Andrew Cope,Vibeke Strand
Publsiher: Oxford University Press, USA
Total Pages: 576
Release: 2020-05-12
ISBN 10: 0198831439
ISBN 13: 9780198831433
Language: EN, FR, DE, ES & NL

Oxford Textbook of Rheumatoid Arthritis Book Review:

The Oxford Textbook of Rheumatoid Arthritis covers all relevant aspects of the fisease, ranging from basic science, epidemiology, clinical and laboratory assessments, drug and non-drug treatments, and disease outcomes. Written by an international team of experts, it will be an invaluable resource for those involved with people with RA.

Role of Neutrophils in Disease Pathogenesis

Role of Neutrophils in Disease Pathogenesis
Author: Maitham Khajah
Publsiher: BoD – Books on Demand
Total Pages: 180
Release: 2017-06-07
ISBN 10: 9535131958
ISBN 13: 9789535131953
Language: EN, FR, DE, ES & NL

Role of Neutrophils in Disease Pathogenesis Book Review:

This book highlights the important role of neutrophils in health as well as in the pathogenesis of various diseases. Section 1 provides a general background information regarding the mechanisms and various triggers of neutrophil extracellular traps (NETs) formation and their role in various infectious and noninfectious diseases (such as postinjury inflammation). Section 2 provides recent evidence regarding the role of neutrophils in the pathogenesis as well as a therapeutic target for selected disease conditions such as periodontal diseases, rheumatoid arthritis, and cystic fibrosis. Section 3 describes the anti-inflammatory properties of neutrophils with focus regarding their role in graft versus host disease. This book provides a wider picture with regard to the importance of this immune cell type in various diseases with focus on one of its recently discovered properties, NETs. Therapeutic targets aimed to modulate neutrophil functions might provide novel approaches in the treatment of various diseases of infectious and noninfectious origin.

Damage Associated Molecular Patterns in Human Diseases

Damage Associated Molecular Patterns in Human Diseases
Author: Walter Gottlieb Land
Publsiher: Springer
Total Pages: 870
Release: 2018-10-09
ISBN 10: 3319786555
ISBN 13: 9783319786551
Language: EN, FR, DE, ES & NL

Damage Associated Molecular Patterns in Human Diseases Book Review:

This book presents current understanding of the importance of modern immunology in the etiopathogenesis of human diseases and explores how this understanding is impacting on diagnosis, prognosis, treatment, and prophylaxis. As the core of modern immunology, the “danger/injury model” is introduced and addressed throughout the book. Volume I of the book describes the network of damage-associated molecular pattern molecules (DAMPs) and examines the central role of DAMPs in cellular stress responses and associated regulated cell death, the promotion and resolution of inflammation, the activation of innate lymphoid cells and unconventional T cells, the stimulation of adaptive immunity, and tissue repair. The significance of DAMPs in a wide range of human diseases will then be explored in Volume II of the book, with discussion of the implications of injury-induced innate immunity for present and future treatments. This book is written for professionals from all medical and paramedical disciplines who are interested in the introduction of innovative data from immunity and inflammation research into clinical practice. The readership will include practitioners and clinicians such as hematologists, rheumatologists, traumatologists, oncologists, intensive care anesthetists, endocrinologists such as diabetologists, psychiatrists, neurologists, pharmacists, and transplantologists.

Physical Phenotyping of Neutrophil NETosis Using Fluorescence Imaging Deformability Cytometry

Physical Phenotyping of Neutrophil NETosis Using Fluorescence Imaging Deformability Cytometry
Author: Hector Enrique Munoz
Publsiher: Unknown
Total Pages: 176
Release: 2020
ISBN 10:
ISBN 13: OCLC:1163649372
Language: EN, FR, DE, ES & NL

Physical Phenotyping of Neutrophil NETosis Using Fluorescence Imaging Deformability Cytometry Book Review:

The cell mechanical phenotype is a useful measure to understand cell identity and state. Cell mechanical properties such as deformability can provide an understanding of cellular processes or intracellular composition without direct labeling. The cell nucleus is a significant component of the cell and it is useful to understand how it impacts cell deformability. However, high throughput methods to measure cell deformability largely cannot directly integrate nuclear information. Here we present fluorescent imaging deformability cytometry (FI-DC), a high throughput platform capable of measuring cells in flow at 0.5 m/s, while providing simultaneous brightfield and fluorescent images. This technology enables us to identify cell subpopulations by their nuclear structure, as well as identify neutrophils undergoing neutrophil extracellular trap (NET) generation.

The Role of Galectin 3 mediated NETosis in Systemic Lupus Erythematosus

The Role of Galectin 3 mediated NETosis in Systemic Lupus Erythematosus
Author: 陳璟儀
Publsiher: Unknown
Total Pages: 39
Release: 2017
ISBN 10:
ISBN 13: OCLC:1021105597
Language: EN, FR, DE, ES & NL

The Role of Galectin 3 mediated NETosis in Systemic Lupus Erythematosus Book Review:

On the Role of Neutrophils and NETosis in Acute Pancreatitis

On the Role of Neutrophils and NETosis in Acute Pancreatitis
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 2020
ISBN 10: 9789176199817
ISBN 13: 9176199819
Language: EN, FR, DE, ES & NL

On the Role of Neutrophils and NETosis in Acute Pancreatitis Book Review:

Apoptosis and Beyond 2 Volume Set

Apoptosis and Beyond  2 Volume Set
Author: James A. Radosevich
Publsiher: John Wiley & Sons
Total Pages: 784
Release: 2018-09-25
ISBN 10: 111943243X
ISBN 13: 9781119432432
Language: EN, FR, DE, ES & NL

Apoptosis and Beyond 2 Volume Set Book Review:

These volumes teach readers to think beyond apoptosis and describes all of the known processes that cells can undergo which result in cell death This two-volume source on how cells dies is the first, comprehensive collection to cover all of the known processes that cells undergo when they die. It is also the only one of its kind to compare these processes. It seeks to enlighten those in the field about these many processes and to stimulate their thinking at looking at these pathways when their research system does not show signs of activation of the classic apoptotic pathway. In addition, it links activities like the molecular biology of one process (eg. Necrosis) to another process (eg. apoptosis) and contrasts those that are close to each. Volume 1 of Apoptosis and Beyond: The Many Ways Cells Die begins with a general view of the cytoplasmic and nuclear features of apoptosis. It then goes on to offer chapters on targeting the cell death mechanism; microbial programmed cell death; autophagy; cell injury, adaptation, and necrosis; necroptosis; ferroptosis; anoikis; pyronecrosis; and more. Volume 2 covers such subjects as phenoptosis; pyroptosis; hematopoiesis and eryptosis; cyclophilin d-dependent necrosis; and the role of phospholipase in cell death. Covers all known processes that dying cells undergo Provides extensive coverage of a topic not fully covered before Offers chapters written by top researchers in the field Provides activities that link and contrast processes to each other Apoptosis and Beyond: The Many Ways Cells Die will appeal to students and researchers/clinicians in cell biology, molecular biology, oncology, and tumor biology.

Neutrophil Methods and Protocols

Neutrophil Methods and Protocols
Author: Mark T. Quinn,Frank R. DeLeo,Gary M. Bokoch
Publsiher: Springer Science & Business Media
Total Pages: 537
Release: 2007-08-02
ISBN 10: 1588297888
ISBN 13: 9781588297884
Language: EN, FR, DE, ES & NL

Neutrophil Methods and Protocols Book Review:

This book provides a concise set of protocols for assessing basic neutrophil functions, investigating specialized areas in neutrophil research, and completing step-by-step diagnostic assays of common neutrophil disorders. Each of the protocols is written by leading researchers in the field and includes hints for success, as well as guidance for troubleshooting. Scientists and clinicians will find this collection an invaluable aid.

Healthy and Beauty Finding of current life science experiment for human sustainability

Healthy and Beauty  Finding of current life science experiment for human sustainability
Author: Mohd Hilmi Abu Bakar
Publsiher: GRIN Verlag
Total Pages: 27
Release: 2019-08-08
ISBN 10: 3668995664
ISBN 13: 9783668995666
Language: EN, FR, DE, ES & NL

Healthy and Beauty Finding of current life science experiment for human sustainability Book Review:

Abstract from the year 2019 in the subject Medicine - Public Health, grade: 10.0, , language: English, abstract: This work is a collection of studies concerning human sustainability. We were proud for having Postgrad Colloquium 2019, Faculty of Health Sciences Universiti Sultan Zainal Abidin (UniSZA). It was held on 30th April 2019 at Academic Building UniSZA Main Campus Kuala Nerus, Terengganu, Malaysia. Total of 24 students including 15 students from Laboratory Based Research category and 9 students from Community Based Research category of Faculty Health Sciences and Faculty of Medicine were participated. We congratulated to the winners Omar Mahmoud Said Alshajrawi from Faculty of Medicine, Masters student for the Laboratory Based Research category and Mohd Ibrahim Abdullah from Faculty of Health Sciences, Doctorate student for the Community Based Research category. Both of you were pretty amazing. See again next year on 2020 to all researchers.

Cell Biology by the Numbers

Cell Biology by the Numbers
Author: Ron Milo,Rob Phillips
Publsiher: Garland Science
Total Pages: 400
Release: 2015-12-07
ISBN 10: 1317230698
ISBN 13: 9781317230694
Language: EN, FR, DE, ES & NL

Cell Biology by the Numbers Book Review:

A Top 25 CHOICE 2016 Title, and recipient of the CHOICE Outstanding Academic Title (OAT) Award. How much energy is released in ATP hydrolysis? How many mRNAs are in a cell? How genetically similar are two random people? What is faster, transcription or translation?Cell Biology by the Numbers explores these questions and dozens of others provid

Fibrinolysis and Thrombolysis

Fibrinolysis and Thrombolysis
Author: Krasimir Kolev
Publsiher: BoD – Books on Demand
Total Pages: 208
Release: 2014-05-07
ISBN 10: 9535112651
ISBN 13: 9789535112655
Language: EN, FR, DE, ES & NL

Fibrinolysis and Thrombolysis Book Review:

This book familiarizes the reader with some recent trends in the theory and practice of thrombolysis. It covers the field of fibrinolysis from the standpoint of basic scientists and clinicians and delivers the state-of-the-art information on the biochemistry and pharmacology of fibrinolysis, as well as related novel methodological and diagnostic tools in the field. An introductory chapter summarizes the basic molecular mechanisms in fibrinolysis (plasminogen, its endogenous activators and their inhibitors, plasmin and its inhibitors). Recent developments in our understanding of fibrin formation are described in the context of its impact on fibrinolysis. The discussion of neutrophil extracellular traps in the modulation of fibrin assembly and the consequences regarding plasminogen activation and plasmin action addresses a novel aspect of fibrinolysis.

Vitamin C in Health and Disease

Vitamin C in Health and Disease
Author: Anitra C. Carr,Jens Lykkesfeldt
Publsiher: MDPI
Total Pages: 298
Release: 2018-08-09
ISBN 10: 3038970298
ISBN 13: 9783038970293
Language: EN, FR, DE, ES & NL

Vitamin C in Health and Disease Book Review:

This book is a printed edition of the Special Issue "Vitamin C in Health and Disease" that was published in Nutrients

Cellular and Molecular Pathobiology of Cardiovascular Disease

Cellular and Molecular Pathobiology of Cardiovascular Disease
Author: Monte Willis,Jonathon W. Homeister,James R. Stone
Publsiher: Academic Press
Total Pages: 338
Release: 2013-12-23
ISBN 10: 0124055257
ISBN 13: 9780124055254
Language: EN, FR, DE, ES & NL

Cellular and Molecular Pathobiology of Cardiovascular Disease Book Review:

Cellular and Molecular Pathobiology of Cardiovascular Disease focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine. No other single text-reference combines clinical cardiology and cardiovascular pathology with enough molecular content for graduate students in both biomedical research and clinical departments. The text is complemented and supported by a rich variety of photomicrographs, diagrams of molecular relationships, and tables. It is uniquely useful to a wide audience of graduate students and post-doctoral fellows in areas from pathology to physiology, genetics, pharmacology, and more, as well as medical residents in pathology, laboratory medicine, internal medicine, cardiovascular surgery, and cardiology. Explains how to identify cardiovascular pathologies and compare with normal physiology to aid research Gives concise explanations of key issues and background reading suggestions Covers molecular bases of diseases for better understanding of molecular events that precede or accompany the development of pathology

Cell Death

Cell Death
Author: Tobias Ntuli
Publsiher: BoD – Books on Demand
Total Pages: 446
Release: 2015-12-16
ISBN 10: 9535122363
ISBN 13: 9789535122364
Language: EN, FR, DE, ES & NL

Cell Death Book Review:

This book is a collection of selected and relevant research, concerning the developments within the Cell Death field of study. Each contribution comes as a separate chapter complete in itself but directly related to the books topics and objectives. The target audience comprises scholars and specialists in the field.

Cytoskeleton

Cytoskeleton
Author: Jose C. Jimenez-Lopez
Publsiher: BoD – Books on Demand
Total Pages: 342
Release: 2017-05-17
ISBN 10: 9535131699
ISBN 13: 9789535131694
Language: EN, FR, DE, ES & NL

Cytoskeleton Book Review:

The cytoskeleton is a highly dynamic intracellular platform constituted by a three-dimensional network of proteins responsible for key cellular roles as structure and shape, cell growth and development, and offering to the cell with "motility" that being the ability of the entire cell to move and for material to be moved within the cell in a regulated fashion (vesicle trafficking). The present edition of Cytoskeleton provides new insights into the structure-functional features, dynamics, and cytoskeleton's relationship to diseases. The authors' contribution in this book will be of substantial importance to a wide audience such as clinicians, researches, educators, and students interested in getting updated knowledge about molecular basis of cytoskeleton, such as regulation of cell vital processes by actin-binding proteins as cell morphogenesis, motility, their implications in cell signaling, as well as strategies for clinical trial and alternative therapies based in multitargeting molecules to tackle diseases, that is, cancer.

Vitamin C and Human Health

Vitamin C and Human Health
Author: Anitra C. Carr,Margreet C. M. Vissers
Publsiher: MDPI
Total Pages: 242
Release: 2018-10-09
ISBN 10: 3906980618
ISBN 13: 9783906980614
Language: EN, FR, DE, ES & NL

Vitamin C and Human Health Book Review:

Printed Edition of the Special Issue Published in Nutrients

Systemic Autoimmunity

Systemic Autoimmunity
Author: P. E. Bigazzi
Publsiher: CRC Press
Total Pages: 320
Release: 1991-08-30
ISBN 10: 9780824785505
ISBN 13: 0824785509
Language: EN, FR, DE, ES & NL

Systemic Autoimmunity Book Review:

Surveys the biotechnologically influenced advances in the understanding of systemic autoimmune disorders, highlighting recent research using cell biology and biochemistry, the cloning of immune cells, recombinant DNA, and molecular genetics. Among the topics are the role of complement in inflammatio