Naturally Occurring Chemicals Against Alzheimer’s Disease

Naturally Occurring Chemicals against Alzheimer’s Disease offers a detailed discussion on the roles, molecular mechanisms, structural activity relationships, toxicology and clinical data on phytochemicals in relation to Alzheimer’s disease. The book examines the available phytochemicals and plants that are potentially effective, also determining the role and molecular targets of these phytochemicals in combating AD. This comprehensive resource will be helpful to researchers who are working on herbal drugs on AD, phytochemistry, pharmacology, toxicology, clinical trials, neuroscience and advancement in formulations. Provides information on phytochemistry, pharmacology, toxicology, clinical trials, and advancement in formulations specific to Alzheimer’s Disease in a single source Explores natural compounds, which can be more affordable to the majority of Alzheimer’s Disease patients, who will increasingly be in developing countries Covers a wide array of specific chemical compounds

Natural products play crucial roles in modern drug development, and constitute a prolific source of novel lead compounds or pharmacophores for ongoing drug discovery programs. Chemistry and Pharmacology of Naturally Occurring Bioactive Compounds presents cutting-edge research in the chemistry of bioactive natural products and demonstrates how natural product research continues to make significant contributions in the discovery and development of new medicinal entities. In 21 chapters, this book highlights chemistry and pharmaceutical potential of natural products in modern drug discovery processes, and covers the synthesis and semi-synthesis of potentially bioactive natural products. Written for phytochemists, synthetic chemists, combinatorial chemists, as well as other practitioners and students in related fields, the book features chemical advances in naturally occurring organic compounds and describes their chemical transformations and structure–activity relationships.

In more than 500 entries, The Encyclopedia of Alzheimer's Disease, Second Edition presents a wealth of information on the physical, emotional, and intellectual conditions that affect Alzheimer's sufferers. It also examines the current research on prevention, causes, and treatments, as well as the social issues surrounding the disease. Appendixes include major resources, organizations, helpful books and publications, an extensive bibliography, and a glossary.

Phytochemicals are naturally occurring bioactive compounds found in edible fruits, plants, vegetables, and herbs. Unlike vitamins and minerals, phytochemicals are not needed for the maintenance of cell viability, but they play a vital role in protecting neural cells from inflammation and oxidative stress associated with normal aging and acute and chronic age-related brain diseases. Neuroprotective Effects of Phytochemicals in Neurological Disorders explores the advances in our understanding of the potential neuroprotective benefits that these naturally occurring chemicals contain. Neuroprotective Effects of Phytochemicals in Neurological Disorders explores the role that a number of plant-based chemical compounds play in a wide variety of neurological disorders. Chapters explore the impact of phytochemicals on neurotraumatic disorders, such as stroke and spinal cord injury, alongside neurodegenerative diseases such as Alzheimer's and Parkinson's Disease, as well as neuropsychiatric disorders such as depression and schizophrenia. The chapters and sections of this book provide the reader with a big picture view of this field of research. Neuroprotective Effects of Phytochemicals in Neurological Disorders aims to present readers with a comprehensive and cutting edge look at the effects of phytochemicals on the brain and neurological disorders in a manner useful to researchers, neuroscientists, clinical nutritionists, and physicians.

Ethnopharmacology is a component of Encyclopedia of Biological, Physiological and Health Sciences in the global Encyclopedia of Life Support Systems (EOLSS), which is an integrated compendium of twenty one Encyclopedias. Ethnopharmacology is the scientific study correlating ethnic groups, their health, and how it relates to their physical habits and methodology in creating and using medicines. This Theme on Ethnopharmacology presents the field as an amalgam of perspectives, primarily those of pharmacology, pharmacognosy, anthropology, and botany. It highlights the uniquely biocultural perspective on ethnopharmacology offered by medical anthropology, which underscores that health and healing are culturally constructed and socially negotiated. The definition of ethnopharmacology that frames this volume is: the study of indigenous medical systems that connects the ethnography of health and healing with the physiological relevance of its medical practices. The history of botanical medicines is traced from primate self-medication to contributions to biomedicine. The methods of ethnopharmacologic inquiry are presented from pharmacologic, ecological, ethnographic, data management, and ethical perspectives. Chapters are devoted to plants used in the treatment of specific disorders: cancer, parasitic infection, AIDS, inflammation, diabetes, and cardiovascular and neurodegenerative disorders. The important role that plant medicines play in the developing world is revealed in discussion of ritual and ceremony, safety issues, health care, and biodiversity. These two volumes are aimed at the following a wide spectrum of audiences from the merely curious to those seeking in-depth knowledge: University and College students Educators, Professional practitioners, Research personnel and Policy analysts, managers, and decision makers and NGOs.

Mammalian Toxicology surveys chemical agents and examines how such chemicals impact on human health, emphasizing the importance in minimizing environmental exposure to chemical and physical hazards in our homes, communities and workplaces through such media as contaminated water, soil and air. Starting with the basic principles on a wide range of toxic agents, this textbook describes how they enter the body, their mechanisms of action once inside, and strategies for diagnosis, prevention and treatment. Topics covered include: General principles of toxicology: pharmacological and toxicological principles underpinning the study of toxicology, risk assessments and mechanisms of cell death Disposition: routes of chemical exposures, entry into the body and various tissues, storage, metabolic biotransformation and elimination, with examples from various toxicants. Toxic agents: the occurrences, disposition in the body, health effects, toxic mechanisms, antidotes and treatments of a range of agents including pesticides, metals, solvents, gases, nanomaterials, food components and additives, pharmaceuticals, drugs of abuse, natural toxins, endocrine disruptors, radiation, and warfare weapons. Toxic effects: including neurotoxicity, developmental toxicity, immunotoxicity, teratogenecity, male and female reproductive toxicity, mutagenecity, carcinogenicity, pulmonary toxicity, cardiovascular toxicity, hepatotoxicity, gastrointestinal toxicity and cardiovascular toxicity Toxicology and society: epidemiological studies of chemical-induced diseases in human populations, and a vision for toxicology in the 21st century. Mammalian Toxicology is an essential primer for students of toxicology, biochemistry, biology, medicine and chemistry. It is also appropriate for professional toxicologists in research or regulatory affairs, and anyone who needs to understand the adverse effects of toxic agents on the human body.

“…a superb collection of practical information and advice for the patient with arthritis.”—Allan Gibofsky, M.D., former president of the American College of Rheumatology Stop living your life with Arthritis pain. Vijay Vad, M.D., author of Back Rx, has written a comprehensive guide that will lead you to a pain free life. You’ll learn simple yoga-and Pilates-based exercises that will treat symptoms in just 15 minutes a day, three times a week. You’ll also learn the role of nutrition, supplements, and weight control in managing and slowing arthritis, including the Arthritis Rx diet. Get a complete look at today’s treatments, medications, and integrative therapies to help you avoid surgery. All studies in this guide were conducted at the prestigious Hospital for Special Surgery, giving you the most accurate information.

Natural compounds, which have evolved their function over millions of years, are often more efficient than man-made compounds if a specific biological activity is needed, e.g. as an enzyme inhibitor or as a toxin to kill a cancer cell. This book comprising of sixteen technical chapters, highlights the chemical and biological aspects of potential natural products with an intention of unravelling their pharmaceutical applicability in modern drug discovery processes. Key features: Covers the synthesis, semi-synthesis and also biosynthesis of potentially bioactive natural products Features chemical and biological advances in naturally occurring organic compounds describing their chemical transformations, mode of actions, and structure-activity relationships 40 expert scientists from around the world report their latest findings and outline future opportunities for the development of novel and highly potent drugs based on natural products operating at the interface of chemistry and biology Forward-looking: Addresses opportunities and cutting-edge developments rather than well-documented basic knowledge, pinpoints current trends and future directions in this rapidly-evolving field Application-oriented: Throughout the book, the focus is on actual and potential applications in pharmacology and biotechnology This book is an essential resource for natural products chemists, medicinal chemists, biotechnologists, biochemists, pharmacologists, as well as the pharmaceutical and biotechnological industries.

Stealing Time is about how and why we age. Research exploring new frontiers on the cellular and genetic levels is providing astonishing insights into the aging process, with evolution and natural selection explaining why some species age more slowly than others and some not at all. Warshofsky also examines the new paradigm of aging: a long life need not be one of disease and decline. He discusses in detail the recent discoveries that have extended the lives of animals and how this breakthrough information offers soon-to-be-realized methods of extending human life. Book jacket.

Now in a new Fourth Edition, Psychiatry remains the leading reference on all aspects of the current practice and latest developments in psychiatry. From an international team of recognised expert editors and contributors, Psychiatry provides a truly comprehensive overview of the entire field of psychiatry in 132 chapters across two volumes. It includes two new sections, on psychosomatic medicine and collaborative care, and on emergency psychiatry, and compares Diagnostic and Statistical Manual (DSM-5) and International Classification of Diseases (ICD10) classifications for every psychiatric disorder. Psychiatry, Fourth Edition is an essential reference for psychiatrists in clinical practice and clinical research, residents in training, and for all those involved in the treatment psychiatric disorders. Includes a a companion website at www.tasmanpsychiatry.com featuring PDFs of each chapter and downloadable images

This volume of peer-reviewed papers is from the symposium of life sciences, materials, and applied chemistry. It provides an opportunity for readers to connect with a selection of refereed papers presented during the 5th International Conference on Science and Technology (ICST 2019, July 30-31, 2019, Yogyakarta, Indonesia). The papers published here reflect on the multiple dimensions of the properties of materials and their application, development technologies of synthesis and processing for goals of biomedicine, pharmacology, food production, agriculture, biomass processing, and environmental engineering.

""Frontiers in Medicinal Chemistry" is an Ebook series devoted to the review of areas of important topical interest to medicinal chemists and others in allied disciplines. "Frontiers in Medicinal Chemistry" covers all the areas of medicinal chemistry, incl"

Expert clinicians and basic scientists with a special interest in Parkinson’s disease review the current state of science and clinical therapeutics of the disease. Therefore these articles represent an authorative review of the current state of knowledge regarding preclinical course and symptomatology, subtypes with their impact on the pathology, genetic alterations, novel mechanisms of neuronal cell death, diagnostic tools and old and novel therapeutic approaches with respect to neuroprotection and neuroregeneration in Parkinson’s disease. Particular emphasis has been placed on a novel antiparkinsonian drug called budipine with various modes of action also influencing altered non dopaminergic systems in Parkinson’s disease. It is evident, that many questions on the cause, course and treatment of Parkinson’s disease are still unanswered and therefore the ideal way to treat a parkinsonian patient remains to be defined.

Cholinesterases—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Cholinesterases. The editors have built Cholinesterases—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cholinesterases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cholinesterases—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

This new book, from the editor of the highly successful Pharmaceutical Analysis, sets out to define the area of pharmaceutical chemistry as distinct from medicinal chemistry. It focuses less on prototypes of drugs that perhaps never came to market and more on the drugs currently in use. The emphasis in the book is on the physicochemical properties of drug molecules and, in so far as they are known, the way that these properties govern the interaction of the drug with its target. Important physicochemical properties include pKa and partition coefficient and the properties of the structural elements within the drug which provide interactions with the target via a range of intermolecular forces. The last fifteen years has seen a great advance in the knowledge of protein structures and a strong emphasis is given to the interaction of drugs with proteins which shape the majority of drug mechanisms. Features: Focus on intramolecular actions Mechanisms of action richly illustrated Self-assessment included Comprehensive chapters on vitamins and biotechnological products This new book, from the editor of the highly successful Pharmaceutical Analysis, sets out to define the area of pharmaceutical chemistry as distinct from medicinal chemistry. It focuses less on prototypes of drugs that perhaps never came to market and more on the drugs currently in use. The emphasis in the book is on the physicochemical properties of drug molecules and, in so far as they are known, the way that these properties govern the interaction of the drug with its target. Important physicochemical properties include pKa and partition coefficient and the properties of the structural elements within the drug which provide interactions with the target via a range of intermolecular forces. The last fifteen years has seen a great advance in the knowledge of protein structures and a strong emphasis is given to the interaction of drugs with proteins which shape the majority of drug mechanisms. Features: Focus on intramolecular actions Mechanisms of action richly illustrated Self-assessment included Comprehensive chapters on vitamins and biotechnological products

Stress and Your Health: From Vulnerability to Resilience presents an evidence-based evaluation of the various effects of stress, along with methods to alleviate distress and stress-related illnesses. Examines myriad stressor effects and proven ways to alleviate stress in our lives Covers a wide range of stressor-related topics including therapeutic strategies to deal with stress and factors that hinder treatment of stress Makes difficult biochemical and immunological concepts accessible to a non-specialist audience Addresses many of the factors that cause individuals to be more vulnerable to the impact of stressors and at increased risk for pathology