Nanoparticles and the Immune System

Nanoparticles and the Immune System
Author: Diana Boraschi,Albert Duschl
Publsiher: Academic Press
Total Pages: 138
Release: 2013-11-29
ISBN 10: 0124079210
ISBN 13: 9780124079212
Language: EN, FR, DE, ES & NL

Nanoparticles and the Immune System Book Review:

Nanoparticles and the Immune System provides a reference text for toxicologists, materials scientists and regulators and covers the key issues of interaction of nanomaterials with the immune system. The book discusses several issues that toxicologists and regulators need to know: identification of endpoints that are relevant for assessing hazard, evaluating impact on immunologically frail populations, and how to evaluate chronic/cumulative effects. In addition, the book addresses the possibility of turning the immunomodulating properties of certain nanomaterials to our advantage for amplifying immune responses in certain diseases or preventive strategies (e.g. vaccination). Identifies endpoints relevant for assessing hazardous situations, evaluating the impact on immunologically frail populations and how to gauge chronic/cumulative effects Raises the awareness of the importance of knowing the effects of the new nanomaterials on our immune system

Interaction of Nanomaterials With the Immune System Role in Nanosafety and Nanomedicine

Interaction of Nanomaterials With the Immune System  Role in Nanosafety and Nanomedicine
Author: Paola Italiani,Diana Boraschi,Lucio R. C. Castellano,Paulo Bonan,Eliton S. Medeiros
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2018-04-10
ISBN 10: 2889453871
ISBN 13: 9782889453870
Language: EN, FR, DE, ES & NL

Interaction of Nanomaterials With the Immune System Role in Nanosafety and Nanomedicine Book Review:

The immune system has the double role of maintaining tissue integrity and homeostasis and of protecting the organism from possible dangers, from invading pathogens to environmentally-borne dangerous chemicals. New chemicals recognisable by the immune system are engineered nanomaterials/ nanoparticles, new agents in our environment that are becoming common due to their presence in many products, from constructions and building material (e.g., solar cells, pigments and paints, tilesand masonry materials) to daily products (e.g., food packaging, cosmetics, and cigarettes). Human beings can be accidentally exposed to engineered nanomaterials when these are released from products containing them or during production in workplaces. Furthermore, intentional exposure occurs in medicine, as engineered nanoparticles are used as tools for improving delivery of drugs and vaccines, vaccine adjuvants and contrast agents in therapeutic, preventive and diagnostic strategies. Nanoparticles that come in contact with the immune system after unintentional exposure need to be eliminated from the organism as they represent a potential threat. In this case, however, due to their peculiar characteristics of size, shape, surface charge and persistence, nanoparticles may elicit undesirable reactions and have detrimental effects on the immune system, such as cytotoxicity, inflammation, anaphylaxis, immunosuppression. Conversely, nanomedicines need to escape immune recognition/elimination and must persist in the organism long enough for reaching their target and exerting their beneficial effects. Immune cells and molecules at the body surface (airway and digestive mucosae, skin) are the first that come in contact with nanomaterials upon accidental exposure, while immune effectors in blood are those that more easily come in contact with nanomedical products. Thus, evaluating the interaction of the immune system with nanoparticles/nanomaterials is a topic of key importance both in nanotoxicology and in nanomedicine. Immuno-nanosafety studies consider both accidental exposure to nanoparticles, which may occur by skin contact, ingestion or inhalation (at doses and with a frequency that are not known), and medical exposure, which takes place with a defined administration schedule (route, dose, frequency). Many studies focus on the interaction between the immune system and nanoparticles that, for medical purposes, have been specifically modified to stimulate immunity or to avoid immune recognition, as in the case of vaccine carriers/adjuvants or drug delivery systems, respectively. The aims of this Research Topic is to provide an overview of recent strategies: 1.for assessing the immunosafety of engineered nanomaterials/nanoparticles, in particular in terms of activation of inflammatory responses, such as complement activation and allergic reactions, based on the nanomaterial intrinsic characteristics and on the possible carry-over of bioactive contaminants such as LPS. Production of new nanoparticles taking into account their effects on immune responses, in order to avoid undesirable effects on one hand, and to design particles with desirable effects for medical applications on the other hand; 2.for designing more effective nanomedicines by either avoiding or exploiting their interaction with the immune systems, with particular focus on cancer diagnosis and therapy, and vaccination. This collection of articles gives a comprehensive view of the state-of-the-art of the interaction of nanoparticles with the immune system from the two perspectives of safety and medical use, and aims at providing immunologists with the relevant knowledge for designing improved strategies for immunologically safe nanomaterial applications.

Handbook of Immunological Properties of Engineered Nanomaterials

Handbook of Immunological Properties of Engineered Nanomaterials
Author: Marina A. Dobrovolskaia,Scott E. McNeil
Publsiher: World Scientific
Total Pages: 692
Release: 2013
ISBN 10: 9814390259
ISBN 13: 9789814390255
Language: EN, FR, DE, ES & NL

Handbook of Immunological Properties of Engineered Nanomaterials Book Review:

The Handbook of Immunological Properties of Engineered Nanomaterials provides a comprehensive overview of the current literature, methodologies, and translational and regulatory considerations in the field of nanoimmunotoxicology. The main subject is the immunological properties of engineered nanomaterials. Focus areas include interactions between engineered nanomaterials and red blood cells, platelets, endothelial cells, professional phagocytes, T cells, B cells, dendritic cells, complement and coagulation systems, and plasma proteins, with discussions on nanoparticle sterility and sterilization. Each chapter presents a broad literature review of the given focus area, describes protocols and resources available to support research in the individual focus areas, highlights challenges, and outlines unanswered questions and future directions. In addition, the Handbook includes an overview of and serves a guide to the physicochemical characterization of engineered nanomaterials essential to conducting meaningful immunological studies of nanoparticles. Regulations related to immunotoxicity testing of materials prior to their translation into the clinic are also reviewed.The Handbook is written by top experts in the field of nanomedicine, nanotechnology, and translational bionanotechnology, representing academia, government, industry, and consulting organizations, and regulatory agencies. The Handbook is designed to serve as a textbook for students, a practical guide for research laboratories, and an informational resource for scientific consultants, reviewers, and policy makers. It is written such that both experts and beginners will find the information highly useful and applicable.

Interaction of Nanomaterials with the Immune System

Interaction of Nanomaterials with the Immune System
Author: James C. Bonner,Jared M. Brown
Publsiher: Springer Nature
Total Pages: 223
Release: 2020-01-30
ISBN 10: 3030339629
ISBN 13: 9783030339623
Language: EN, FR, DE, ES & NL

Interaction of Nanomaterials with the Immune System Book Review:

This book covers the latest information related to understanding immune responses to engineered nanomaterials (ENMs). Many ENMs used in both the consumer and biomedical fields have been reported to elicit adverse immune responses ranging from innate immune responses such as complement activation to changes in adaptive immunity that influence pathogen responses and promote disease states such as asthma. Interaction of Nanomaterials with the Immune System covers the most up to date information on our understanding of immune responses to ENMs across a wide range of topics including innate immunity, allergic immune responses, adaptive provides the reader with (1) up to date understanding of immune responses to ENMs; (2) current testing methods; and (3) appropriate models including alternative testing strategies for evaluating immunotoxicity of ENMs.

Nanoparticle Vaccines Against Infectious Diseases

Nanoparticle Vaccines Against Infectious Diseases
Author: Rajko Reljic,África González-Fernández
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2020-01-15
ISBN 10: 2889633276
ISBN 13: 9782889633272
Language: EN, FR, DE, ES & NL

Nanoparticle Vaccines Against Infectious Diseases Book Review:

Interactions of Engineered and Endogenous Nanoparticles with Cells in the Immune System

Interactions of Engineered and Endogenous Nanoparticles with Cells in the Immune System
Author: Helen Vallhov
Publsiher: Unknown
Total Pages: 135
Release: 2010
ISBN 10: 9789174095449
ISBN 13: 9174095447
Language: EN, FR, DE, ES & NL

Interactions of Engineered and Endogenous Nanoparticles with Cells in the Immune System Book Review:

Nanotechnology is a fast developing area, which refers to research and technology development at the nanometer scale, ranging from 0.1-100 nm. The properties of nanomaterials offer the ability to interact with complex biological functions, implying enormous opportunities for novel applications within medicine. However, there is little information available concerning the potential toxicity of nanoparticles and what influence such particles have on the immune system, e.g. on dendritic cells (DCs). DCs are the most efficient antigen presenting cells, having a capacity to initiate and direct immune responses against foreign material. The aim of this thesis was to study effects of differently sized and shaped nanomaterials in the interaction with primary human monocyte derived DCs (MDDCs), thereby obtaining an insight on what impact these materials have on the immune system and their potential use in medical applications. In addition, we wanted to determine if endogenous nanoparticles (exosomes), produced by various cells, are natural targeting vehicles. We show that conventionally produced gold nanoparticles had a maturing effect on human MDDCs, but this was found to be a result of lipopolysaccharide (LPS) contamination. By modification of the production process, clean particles were obtained, which had practically no effect on phenotype or cytokine production of MDDCs. These findings emphasize the importance of retaining high purity during the production of nanoparticles, since possible contaminants may interfere with the assessment of nanoparticles biological effects and result in hazardous particles. To investigate whether various shapes of gold nanoparticles affect MDDC differently, a novel method was developed for the preparation of gold nanorods with high aspect ratios (ARs) based on a self-seeded surfactant-mediated protocol. The biocompatibility of these high AR gold nanorods, with potential use in thermal therapy, was compared with spherical gold nanoparticles

Nanoparticle Mediated Immunotherapy

Nanoparticle Mediated Immunotherapy
Author: Tuan Vo-Dinh
Publsiher: Springer Nature
Total Pages: 135
Release: 2022
ISBN 10: 3030783383
ISBN 13: 9783030783389
Language: EN, FR, DE, ES & NL

Nanoparticle Mediated Immunotherapy Book Review:

Novel Immunologic Adjuvants

Novel Immunologic Adjuvants
Author: Rino Rappuoli,Ennio De Gregorio
Publsiher: Future Medicine Ltd
Total Pages: 111
Release: 2011-10
ISBN 10: 1780840047
ISBN 13: 9781780840048
Language: EN, FR, DE, ES & NL

Novel Immunologic Adjuvants Book Review:

The study of adjuvants substances added to vaccine formulations to increase efficacy is one of the fastest growing disciplines in immunology and vaccine development. This book reviews the state-of-the-art of development of novel adjuvants and the science that supports them. There is an increasing need of novel adjuvants for preventive vaccines targeting infectious diseases for which conventional formulations have failed. New adjuvants are also needed to improve existing vaccines in the elderly, infants and chronically infected individuals that mount a suboptimal immune response. In addition, adjuvants could be very useful for the development of effective therapeutic vaccines against chronic infections and cancer. In this context, the book provides an overview of vaccine adjuvants with a special focus on their composition and mechanism of action.

Immunization

Immunization
Author: Ning Wang,Ting Wang
Publsiher: BoD – Books on Demand
Total Pages: 122
Release: 2018-11-28
ISBN 10: 1789845386
ISBN 13: 9781789845389
Language: EN, FR, DE, ES & NL

Immunization Book Review:

Immunization plays a key role in maintaining human health and each year, saves millions of lives from lethal pathogens and other fatal diseases in the most economical way, thanks to the advanced development of model vaccines. Subunit vaccines are regarded as a safer product than the whole microbe based-conventional vaccines and can be entrapped in various nanocarriers to form a vaccine adjuvant-delivery system (VADS) able to further boost their immunostimulatory activity. In this book, six groups of authors introduce immunization advances in VADSs designed for infection prophylaxis and cancer immunotherapy, problems and their resolution in both human and poultry immunization, and also, the mathematical model for assay of the basic immunization problem (BIP) understood from a finance point of view.

Emerging Nanotechnologies in Immunology

Emerging Nanotechnologies in Immunology
Author: Ranjita Shegokar,Eliana B. Souto
Publsiher: William Andrew
Total Pages: 290
Release: 2018-05-17
ISBN 10: 0323401139
ISBN 13: 9780323401135
Language: EN, FR, DE, ES & NL

Emerging Nanotechnologies in Immunology Book Review:

Emerging Nanotechnologies in Immunology: The Design, Applications and Toxicology of Nanopharmaceuticals and Nanovaccines aims to deliver a systematic and comprehensive review of data concerning the nature of interaction and nano-related risks between the nanopharmaceuticals currently in the pipeline of S&T development for skin, ocular and nasal drug delivery, including absorption, toxicity, and the ability to distribute after systemic exposure. The book's contributors address a representative set of the broad spectrum of nanopharmaceutics presently being used, including cationic lipid nanoparticles, polymeric PLGA, PLA nanoparticles, biomacromolecules-based nanoparticles, and other scaffolds tissue-engineered skin substitutes. In addition, regulation and risk are also covered since the safety of these nanopharmaceuticals still represents a barrier to their wide and innovative use. Provides a thorough knowledge of the safety aspects of nanopharmaceuticals currently under research Focuses on the characterization and quantification of nanopharmaceutics to allow readers to understand the correlation between the nature of the materials and their potential nanotoxicological effects Includes a thorough overview of legal and regulatory aspects and a discussion of the ethical issues related to the R&D of nanopharmaceuticals

Micro and Nanotechnology in Vaccine Development

Micro  and Nanotechnology in Vaccine Development
Author: Mariusz Skwarczynski,Istvan Toth
Publsiher: William Andrew
Total Pages: 460
Release: 2016-09-20
ISBN 10: 0323400299
ISBN 13: 9780323400299
Language: EN, FR, DE, ES & NL

Micro and Nanotechnology in Vaccine Development Book Review:

This book provides a comprehensive overview of how use of micro- and nanotechnology (MNT) has allowed major new advance in vaccine development research, and the challenges that immunologists face in making further progress. MNT allows the creation of particles that exploit the inherent ability of the human immune system to recognize small particles such as viruses and toxins. In combination with minimal protective epitope design, this permits the creation of immunogenic particles that stimulate a response against the targeted pathogen. The finely tuned response of the human immune system to small particles makes it unsurprising that many of the lead adjuvants and vaccine delivery systems currently under investigation are based on nanoparticles. Provides a comprehensive and unparalleled overview of the role of micro- and nanotechnology in vaccine development Allows researchers to quickly familiarize themselves with the broad spectrum of vaccines and how micro- and nanotechnologies are applied to their development Includes a combination of overview chapters setting out general principles, and focused content dealing with specific vaccines, making it useful to readers from a variety of disciplines

Silver Nanoparticles

Silver Nanoparticles
Author: David Pozo
Publsiher: IntechOpen
Total Pages: 344
Release: 2010-03-01
ISBN 10: 9789533070285
ISBN 13: 9533070285
Language: EN, FR, DE, ES & NL

Silver Nanoparticles Book Review:

Nanotechnology will be soon required in most engineering and science curricula. It cannot be questioned that cutting-edge applications based on nanoscience are having a considerable impact in nearly all fields of research, from basic to more problem-solving scientific enterprises. In this sense, books like “Silver Nanoparticles” aim at filling the gaps for comprehensive information to help both newcomers and experts, in a particular fast-growing area of research. Besides, one of the key features of this book is that it could serve both academia and industry. “Silver nanoparticles” is a collection of eighteen chapters written by experts in their respective fields. These reviews are representative of the current research areas within silver nanoparticle nanoscience and nanotechnology.

Environmental Influences on the Immune System

Environmental Influences on the Immune System
Author: Charlotte Esser
Publsiher: Springer
Total Pages: 378
Release: 2016-02-04
ISBN 10: 3709118905
ISBN 13: 9783709118900
Language: EN, FR, DE, ES & NL

Environmental Influences on the Immune System Book Review:

This book brings together articles on the overarching theme of how the environment shapes the immune system. The immune system is commonly assumed to respond to harmful pathogens such as bacteria and viruses. However, harmless bacteria, chemicals, stress, normal food and other factors can also trigger, shape or interfere with the immune system, often producing adverse effects. Yet, it is also becoming increasingly accepted that some of these interactions are physiological and necessary for a healthy immune system. Examples of negative effects include the immunosuppressive effects of UV irradiation, or the immunotoxic effects of man-made chemicals such as polycyclic aromatic hydrocarbons. Autoimmunity or allergies can be the adverse consequences of interaction between the immune system and chemical compounds such as drugs. Positive effects can come from natural exposure levels to bacteria, healthy life-style or the diet. There is a great need to understand how communication between the environment and the immune system works. This book addresses this need. It covers environmental factors (such as bacteria, sun exposure), human factors (such as age, exercise or stress), and important man-made factors (such as air pollution). A chapter on human rights complements the scientific chapters. The book is intended for immunologists, toxicologists and researchers who want to know how the immune system works and is triggered, as well as for medical doctors in environmental medicine and the general public interested in immunology.

Emerging Trends in Immunomodulatory Nanomaterials Toward Cancer Therapy

Emerging Trends in Immunomodulatory Nanomaterials Toward Cancer Therapy
Author: Anubhab Mukherjee,Vijay Sagar Madamsetty,Sudip Mukherjee
Publsiher: Morgan & Claypool Publishers
Total Pages: 84
Release: 2021-04-06
ISBN 10: 1636391052
ISBN 13: 9781636391052
Language: EN, FR, DE, ES & NL

Emerging Trends in Immunomodulatory Nanomaterials Toward Cancer Therapy Book Review:

Recently, immunomodulatory nanomaterials have gained immense attention due to their involvement in the modulation of the body’s immune response to cancer therapy. This book highlights various immunomodulatory nanomaterials (including organic, polymer, inorganic, liposomes, viral, and protein nanoparticles) and their role in cancer therapy. Additionally, the mechanism of immunomodulation is reviewed in detail. Finally, the challenges of these therapies and their future outlook are discussed. We believe this book will be helpful to a broad community including students, researchers, educators, and industrialists.

Neurotoxicity of Nanomaterials and Nanomedicine

Neurotoxicity of Nanomaterials and Nanomedicine
Author: Xinguo Jiang,Huile Gao
Publsiher: Academic Press
Total Pages: 358
Release: 2016-10-03
ISBN 10: 0128046201
ISBN 13: 9780128046203
Language: EN, FR, DE, ES & NL

Neurotoxicity of Nanomaterials and Nanomedicine Book Review:

Neurotoxicity of Nanomaterials and Nanomedicine presents an overview of the exciting research in neurotoxicity and nanomaterials. Nanomaterials have been extensively used in medicine, including diagnosis probes, drug carriers, and embedded materials. While some have been approved for clinical use, most nanomaterials are waiting to be transferred from lab to clinic. However, the toxicity is a main barrier that restricts the translation. This comprehensive book includes chapters on the most commonly used individual nanoparticles, with information on the applications, neurotoxicity, and related mechanisms of each, providing the most in-depth and current information available. The book examines the pathways that nanomaterials enter into, and eliminate, from the brain, along with the strategies that could reduce the neurotoxicity of nanomaterials. Providing a background to the subject, detailed information, and ideas for future directions in research, the book is essential for students and researchers in toxicology, and for those in medicine, neurology, pharmacology, pharmaceutical science, and materials science who are researching nanomaterials. Presents a thorough discussion of the most common nanoparticles in the brain and their neurotoxicology Includes the most common nanoparticles, their applications, and mechanisms Provides one of the first books to focus on nanomedicine and neurotoxicity

Nanomaterials Safety

Nanomaterials Safety
Author: Shyamasree Ghosh
Publsiher: Walter de Gruyter GmbH & Co KG
Total Pages: 288
Release: 2018-11-19
ISBN 10: 3110578360
ISBN 13: 9783110578362
Language: EN, FR, DE, ES & NL

Nanomaterials Safety Book Review:

This monograph summarizes the current knowledge on potential health hazards induced by nanomaterials from different sources and sort such as food, drugs and silver nanoparticles. Methods to assess toxicity as well as known effects on the genome, neuronal and respiratory system are discussed. Besides the impact on human and animal life the books also addresses aquatic toxicity.

Nanoparticles Induce Dermal and Intestinal Innate Immune System Responses in Zebrafish Embryos1

Nanoparticles Induce Dermal and Intestinal Innate Immune System Responses in Zebrafish Embryos1
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 2018
ISBN 10: 1928374650XXX
ISBN 13: OCLC:1051852616
Language: EN, FR, DE, ES & NL

Nanoparticles Induce Dermal and Intestinal Innate Immune System Responses in Zebrafish Embryos1 Book Review:

Nanoparticulate Vaccine Delivery Systems

Nanoparticulate Vaccine Delivery Systems
Author: Martin J. D'Souza
Publsiher: CRC Press
Total Pages: 244
Release: 2015-06-01
ISBN 10: 9814613312
ISBN 13: 9789814613316
Language: EN, FR, DE, ES & NL

Nanoparticulate Vaccine Delivery Systems Book Review:

Recent years have seen the development of novel technologies that use nanoparticles and microparticles to deliver vaccines by the oral and microneedle-based transdermal route of administration. These new technologies enable the formulation of vaccine particles containing vaccine antigens, without loss of their biological activity during the formulation process. Also, multiple antigens, targeting ligands, and adjuvants can all be encapsulated within the same particle. When administered orally, these particles are designed to withstand the acidic environment of the stomach and are targeted to Peyer’s patches and the gut-associated mucosal immune system. Since these vaccines are particulate in nature, they are readily taken up by phagocytic antigen-presenting cells, such as M cells, dendritic cells, and macrophages in Peyer’s patches of the intestines, resulting in a strong immune response and antibody production. Since no needles are required for oral vaccines, this method of vaccine delivery is inexpensive and suitable for mass vaccination in the developing world as well as the developed world. This book discusses studies conducted on a wide array of vaccines, including vaccines for infectious diseases such as tuberculosis, typhoid, influenza, pneumonia, meningitis, human papillomavirus, and hepatitis B. It also discusses recent studies on vaccines for cancers such as melanoma and ovarian, breast, and prostate cancer.

Allergy and Immunotoxicology in Occupational Health

Allergy and Immunotoxicology in Occupational Health
Author: Takemi Otsuki,Claudia Petrarca,Mario Di Gioacchino
Publsiher: Springer
Total Pages: 152
Release: 2016-10-12
ISBN 10: 9811003513
ISBN 13: 9789811003516
Language: EN, FR, DE, ES & NL

Allergy and Immunotoxicology in Occupational Health Book Review:

This book offers a collection of the latest clinical and research findings related to allergies, one of the most frequently treated conditions in occupational medicine. The chapters not only cover asthma but also elaborate on contact dermatitis, rhinitis, and other allergic conditions, providing readers with a comprehensive overview of the substances disrupting autoimmunity and their effects on the human body. Allergy and Immunotoxicology in Occupational Health is a valuable resource for professionals and researchers in the occupational health sector, who will discover novel insights into immune effects, providing a foundation for future considerations of the health impairments caused by environmental and occupational exposure to these substances.

Metal Nanoparticles

Metal Nanoparticles
Author: Sreekanth Thota,Debbie C. Crans
Publsiher: John Wiley & Sons
Total Pages: 265
Release: 2018-06-28
ISBN 10: 3527821449
ISBN 13: 9783527821440
Language: EN, FR, DE, ES & NL

Metal Nanoparticles Book Review:

A much-needed summary of the importance, synthesis and applications of metal nanoparticles in pharmaceutical sciences, with a focus on gold, silver, copper and platinum nanoparticles. After a brief introduction to the history of metal complexes in medicine and fundamentals of nanotechnology, the chapters continue to describe different methods for preparation of metal nanoparticles. This section is followed by representative presentations of current biomedical applications, such as drug delivery, chemotherapy, and diagnostic imaging. Aimed at stimulating further research in this field, the book serves as an reference guide for academics and professionals working in the field of chemistry and nanotechnology.