Muscular Dystrophies

Muscular Dystrophies
Author: Robert C. Griggs,Anthony A. Amato
Publsiher: Elsevier
Total Pages: 284
Release: 2011-05-24
ISBN 10: 044453489X
ISBN 13: 9780444534897
Language: EN, FR, DE, ES & NL

Muscular Dystrophies Book Review:

The Handbook of Clinical Neurology Vol 101: Muscular Dystrophies discusses the pathogenesis and treatment prospects for muscular dystrophies. It summarizes the advances in molecular and cell biology, biochemistry, and other biological sciences, with an emphasis on their application to this group of muscle disorders and to their clinical implications. Starting with an overview of muscular dystrophies, the book’s 16 chapters discuss dystrophinopathies; sarcoglycanopathies; congenital muscular dystrophies; collagen VI-related myopathies; limb-girdle muscular dystrophy 2A; dysferlinopathies; limb-girdle muscular dystrophy 2H and the role of TRIM32; and caveolinopathies. The book also covers myofibrillar myopathies; Emery-Dreifuss muscular dystrophy; facioscapulohumeral dystrophy and scapuloperoneal syndromes; oculopharyngeal muscular dystrophy; myotonic dystrophy types 1 and 2; and distal muscular dystrophies. This book is useful to basic investigators, as it offers an increased understanding of muscular dystrophies; and to clinicians, with its emphasis on issues that are relevant to the care, diagnosis, and management of patients with these disorders. Valuable insights into the muscular dystrophies, including treatment, diagnosis, and care and patient management A comprehensive compilation of the combined wisdom of the most highly regarded physicians, experts, and scientists studying the muscular dystrophies An evaluation of the way advances in molecular and cell biology, biochemistry, and other biological sciences continue to advance the study of these disorders

Molecular Mechanisms of Muscular Dystrophies

Molecular Mechanisms of Muscular Dystrophies
Author: Steve J. Winder
Publsiher: CRC Press
Total Pages: 250
Release: 2006-01-26
ISBN 10: 1498713963
ISBN 13: 9781498713962
Language: EN, FR, DE, ES & NL

Molecular Mechanisms of Muscular Dystrophies Book Review:

There is no doubt that the study of the muscular dystrophies in recent years has been exciting and rewarding. It has attracted the attention of many investigators of international repute, and this is reflected in the various contributions to this volume. Molecular Mechanisms of Muscular Dystrophies represents a personal collection of chapters cover

Muscle Cell and Tissue

Muscle Cell and Tissue
Author: Kunihiro Sakuma,Nobuo Morotomi
Publsiher: BoD – Books on Demand
Total Pages: 130
Release: 2021-07-07
ISBN 10: 1839686502
ISBN 13: 9781839686504
Language: EN, FR, DE, ES & NL

Muscle Cell and Tissue Book Review:

The loss of skeletal muscle mass and strength substantially impairs physical performance and quality of life. This book details some approaches to the treatment of muscle wasting. It also reviews novel applications against pulmonary arterial hypertension such as cell reprogramming and the use of anticancer drugs that induce programmed cell death. Vascular smooth muscle cells (VSMCs) are the most prevalent cell types in blood vessels and serve critical regulatory roles. This publication also introduces mathematical models concerning the molecular mechanism and targets of cyclic guanosine 3′,5′-monophosphate (cGMP) in the contraction of VSMCs. This book will be of interest to professionals in clinical practice, medical and health care students, and researchers working in muscle-related fields of science.

Muscular Dystrophies

Muscular Dystrophies
Author: Kunihiro Sakuma
Publsiher: BoD – Books on Demand
Total Pages: 130
Release: 2019-10-02
ISBN 10: 1789238455
ISBN 13: 9781789238457
Language: EN, FR, DE, ES & NL

Muscular Dystrophies Book Review:

Skeletal muscle is a highly plastic organ that is modulated by various pathways controlling protein turnover. Muscle loss is common in muscular dystrophy, in which marked loss of various proteins such as the dystrophin-glycoprotein complex occurs around muscle fibers. This book provides a comprehensive overview of the various muscular dystrophies, including characteristics, diagnosis, and classification. General treatment of drugs (e.g. corticosteroids) and physical therapy for muscular dystrophies are discussed. In addition, current applications for cell and tissue engineering using muscle stem cells or gene therapy are introduced. This book also deals with the recent advances in appropriate models of drug screening using cell cultures or mammalian organs in vitro in this field.

Muscular Dystrophy

Muscular Dystrophy
Author: Alan E. H. Emery
Publsiher: OUP Oxford
Total Pages: 160
Release: 2008-03-06
ISBN 10: 9780191580109
ISBN 13: 0191580104
Language: EN, FR, DE, ES & NL

Muscular Dystrophy Book Review:

The muscular dystrophies are a group of genetic diseases that severely affect children and adults. For sufferers and their family, the illness presents enormous physical and psychological challenges. Written specifically for people with muscular dystrophy and their families, this book answers many of the questions asked about how and why muscular dystrophy occurs, and how it will affect the life of a recently diagnosed child. As well as presenting the reader with advice and an explanation of muscular dystrophy, the book also guides the reader towards further information on societies and support groups around the world, and reliable internet resources. It also contains a full glossary to aid the reader in their understanding of the disease. The different types of muscular dystrophy are described throughout with a minimum of technical jargon. Questions relating to exercise, physiotherapy, surgery, and the emotional effects of the diseases are answered, and advice is given on the problems of schooling and choice of career. Since publication of the first edition in 1994, the genes for almost all the different types of dystrophy have been identified, enabling prevention through genetic counselling, therefore relieving some of the worry for affected families. Drawn from his many years of experience treating patients, Professor Emery provides authoritative, yet compassionate advice for people living with this illness.

Muscular Dystrophy

Muscular Dystrophy
Author: Alan E. H. Emery
Publsiher: Unknown
Total Pages: 166
Release: 2000
ISBN 10: 9780192632173
ISBN 13: 0192632175
Language: EN, FR, DE, ES & NL

Muscular Dystrophy Book Review:

The muscular dystrophies are a group of genetic diseases that severely affect children and adults. For sufferers and their family, the illness presents enormous physical and psychological challenges. Written specifically for people with muscular dystrophy and their families, this new editionof Muscular dystrophy: the facts answers many of the questions asked about how and why it occurs, and how it will affect the life of a recently diagnosed child. Throughout, the different types of muscular dystrophy are described with a minimum of technical jargon. Questions relating to exercise,physiotherapy, surgery, and the emotional effects of the diseases are answered, and advice given on the problems of schooling and choice of career. Since publication of the 1st edition, the genes for almost all the different types of dystrophy have been identified, enabling prevention throughgenetic counselling, and relieving some of the worry for affected families. Drawn from his many years of experience treating patients, Professor Emery provides authoritative, yet compassionate advice for people living with this illness. From reviews of 1st edition 'A family visiting a geneticcounsellor readied with information from this book would be well versed in the scope of concerns that can arise as families live with MD. I applaud the effort to make this care package of information available to families.' The American Journal of Human Genetics

Pediatric Neurology Part III

Pediatric Neurology Part III
Author: Jamel Chelly,Isabelle Desguerre
Publsiher: Elsevier Inc. Chapters
Total Pages: 732
Release: 2013-04-24
ISBN 10: 0128084073
ISBN 13: 9780128084076
Language: EN, FR, DE, ES & NL

Pediatric Neurology Part III Book Review:

Infancy- or childhood-onset muscular dystrophies may be associated with profound loss of muscle function, affecting ambulation, posture, cardiac and respiratory functions, while those of late onset may be mild and associated with slight weakness or fatigability induced by effort. In addition to the distribution of muscle weakness, symptoms, and course of the disease, the diagnosis of muscular dystrophy is usually ascertained by histological findings. There is connective tissue proliferation in the perimysium and endomysium, variation in muscle fiber size, cytoarchitectural alterations of myofibers such as internal nuclei, myofibrillar whorls, and fiber splitting and lobulation, but, most of all, degeneration and regeneration of myofibers. Causes of muscular dystrophies characterized by muscle weakness and wasting are heterogeneous and include dysfunction of diverse genetic pathways and genes encoding proteins of the plasma membrane, extracellular matrix, sarcomere, and nuclear membrane components. Duchenne and Becker muscular dystrophies are prototypes illustrating advances in the field of myology. Limb-girdle muscular dystrophies (LGMDs) are clinically and genetically heterogeneous, some with autosomal dominant (LGMD1) and others with autosomal recessive (LGMD2) inheritance. Neither clinical and genetic grounds nor biopsy patterns are specific enough to distinguish them, but two common denominators are: (1) weakness and wasting predominating in pelvic and shoulder girdle muscles, with occasional involvement of the myocardium; and (2) necrosis and regeneration of myofibers. While identification of genetic causes and molecular diagnosis are increasingly improved, especially with the advent of new generation sequencing technologies, optimized care, information for the family, and prevention, including genetic counseling and prenatal diagnosis, require multidisciplinary follow-up with genetic, pediatric, and psychological involvement.

Muscular Dystrophies Advances in Research and Treatment 2011 Edition

Muscular Dystrophies  Advances in Research and Treatment  2011 Edition
Author: Anonim
Publsiher: ScholarlyEditions
Total Pages: 15
Release: 2012-01-09
ISBN 10: 1464962723
ISBN 13: 9781464962721
Language: EN, FR, DE, ES & NL

Muscular Dystrophies Advances in Research and Treatment 2011 Edition Book Review:

Muscular Dystrophies: Advances in Research and Treatment: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Muscular Dystrophies in a compact format. The editors have built Muscular Dystrophies: Advances in Research and Treatment: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Muscular Dystrophies in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Muscular Dystrophies: Advances in Research and Treatment: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

The Muscular Dystrophies

The Muscular Dystrophies
Author: Alan E. H. Emery
Publsiher: Oxford Medical Publications
Total Pages: 316
Release: 2001
ISBN 10:
ISBN 13: UOM:39015054284123
Language: EN, FR, DE, ES & NL

The Muscular Dystrophies Book Review:

The muscular dystrophies are an important group of inherited disorders. They are characterized by muscle wasting and weakness, but vary considerably in their clinical manifestations and severity. This text reviews our understanding of the most important of these disorders. In many instances, the genes and protein products responsible for the dystrophies have been identified and it is now possible to establish a precise diagnosis, detect preclinical cases, identify carriers and offer prenatal dianostic testing. The book goes on to describe the opportunities for management of the symptoms through respiratory care, physiotherapy and surgical correction of contracture, and examines the potential, in the future, for effective treatment utilizing the new techniques of gene and cell therapy. Professor Emery has invited chapters from the leading international experts in the field providing a unique insight into the current situation and the hopes for the future.

Muscular Dystrophies Advances in Research and Treatment 2012 Edition

Muscular Dystrophies   Advances in Research and Treatment  2012 Edition
Author: Anonim
Publsiher: ScholarlyEditions
Total Pages: 32
Release: 2012-12-26
ISBN 10: 1481623109
ISBN 13: 9781481623100
Language: EN, FR, DE, ES & NL

Muscular Dystrophies Advances in Research and Treatment 2012 Edition Book Review:

Muscular Dystrophies—Advances in Research and Treatment: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Muscular Dystrophies in a compact format. The editors have built Muscular Dystrophies—Advances in Research and Treatment: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Muscular Dystrophies in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Muscular Dystrophies—Advances in Research and Treatment: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Limb Girdle Muscular Dystrophies New Insights for the Healthcare Professional 2011 Edition

Limb Girdle Muscular Dystrophies  New Insights for the Healthcare Professional  2011 Edition
Author: Anonim
Publsiher: ScholarlyEditions
Total Pages: 19
Release: 2012-01-09
ISBN 10: 1464913528
ISBN 13: 9781464913525
Language: EN, FR, DE, ES & NL

Limb Girdle Muscular Dystrophies New Insights for the Healthcare Professional 2011 Edition Book Review:

Limb-Girdle Muscular Dystrophies: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Limb-Girdle Muscular Dystrophies in a compact format. The editors have built Limb-Girdle Muscular Dystrophies: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Limb-Girdle Muscular Dystrophies in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Limb-Girdle Muscular Dystrophies: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Muscular Dystrophy

Muscular Dystrophy
Author: Raymond A. Huml
Publsiher: Springer
Total Pages: 191
Release: 2015-07-16
ISBN 10: 3319173626
ISBN 13: 9783319173627
Language: EN, FR, DE, ES & NL

Muscular Dystrophy Book Review:

This practical and concise guide offers an overview of muscular dystrophy's complicated features, treatment options and general resources. New treatments and a greater understanding of proteins and structures associated with MD are discussed along with long term patient care. Also included are clinical and developmental challenges within the current regulatory landscape and recent scientific and clinical advances. Muscular Dystrophy offers clinicians, researchers, pharmaceutical executives and patient advocacy groups an easy-to-read reference that provides the necessary perspectives of the care giver and patient.

Limb Girdle Muscular Dystrophies New Insights for the Healthcare Professional 2011 Edition

Limb Girdle Muscular Dystrophies  New Insights for the Healthcare Professional  2011 Edition
Author: Anonim
Publsiher: ScholarlyEditions
Total Pages: 19
Release: 2012-01-09
ISBN 10: 1464913536
ISBN 13: 9781464913532
Language: EN, FR, DE, ES & NL

Limb Girdle Muscular Dystrophies New Insights for the Healthcare Professional 2011 Edition Book Review:

Limb-Girdle Muscular Dystrophies: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Limb-Girdle Muscular Dystrophies in a compact format. The editors have built Limb-Girdle Muscular Dystrophies: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Limb-Girdle Muscular Dystrophies in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Limb-Girdle Muscular Dystrophies: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Limb Girdle Muscular Dystrophies New Insights for the Healthcare Professional 2012 Edition

Limb Girdle Muscular Dystrophies  New Insights for the Healthcare Professional  2012 Edition
Author: Anonim
Publsiher: ScholarlyEditions
Total Pages: 21
Release: 2012-12-10
ISBN 10: 1464983372
ISBN 13: 9781464983375
Language: EN, FR, DE, ES & NL

Limb Girdle Muscular Dystrophies New Insights for the Healthcare Professional 2012 Edition Book Review:

Limb-Girdle Muscular Dystrophies: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Limb-Girdle Muscular Dystrophies in a compact format. The editors have built Limb-Girdle Muscular Dystrophies: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Limb-Girdle Muscular Dystrophies in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Limb-Girdle Muscular Dystrophies: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Pediatric Neurology Part III

Pediatric Neurology Part III
Author: Janbernd Kirschner
Publsiher: Elsevier Inc. Chapters
Total Pages: 732
Release: 2013-04-24
ISBN 10: 012808409X
ISBN 13: 9780128084090
Language: EN, FR, DE, ES & NL

Pediatric Neurology Part III Book Review:

The congenital muscular dystrophies are a heterogeneous group of disorders in which weakness and dystrophic pattern on muscle biopsy are present at birth or during the first months of life. This chapter reviews the most common forms of congenital muscular dystrophies, including laminin α-2 (merosin) deficiency, Ullrich congenital muscular dystrophy, fukutin-related proteinopathy, rigid spine syndrome, and glycosylation disorders of α-dystroglycan. The latter group is often associated with neuronal migration defects including lissencephaly, pachygyria, cerebellar and brainstem abnormalities, and variable ocular anomalies. Typical clinical findings and underlying genetic defects are discussed to assist in the differential diagnosis and diagnostic work-up of patients with congenital muscular dystrophies. There are still no curative treatment options for patients with congenital muscular dystrophies but regular follow-up and symptomatic care by a multidisciplinary team considering the peculiarities of each disorder are important to maintain or improve patients’ quality of life.

Duchenne Muscular Dystrophy

Duchenne Muscular Dystrophy
Author: Alan E. H. Emery,Francesco Muntoni,Rosaline C. M. Quinlivan
Publsiher: OUP Oxford
Total Pages: 320
Release: 2015-02-19
ISBN 10: 0191503665
ISBN 13: 9780191503665
Language: EN, FR, DE, ES & NL

Duchenne Muscular Dystrophy Book Review:

Duchenne Muscular Dystrophy, an inherited and progressive muscle wasting disease, is one of the most common single gene disorders found in the developed world. In this fourth edition of the classic monograph on the topic, Alan Emery and Francesco Muntoni are joined by Rosaline Quinlivan, Consultant in Neuromuscular Disorders, to provide a thorough update on all aspects of the disorder. Recent understanding of the nature of the genetic defect responsible for Duchenne Muscular Dystrophy and isolation of the protein dystrophin has led to the development of new theories for the disease's pathogenesis. This new edition incorporates these advances from the field of molecular biology, and describes the resultant opportunities for screening, prenatal diagnosis, genetic counselling and from recent pioneering work with anti-sense oligonucleotides, the possibility of effective RNA therapy. Although there is still no cure for the disorder, there have been significant developments concerning the gene basis, publication of standards of care guidelines, and improvements in management leading to significantly longer survival, particularly with cardio-pulmonary care. The authors also investigate other forms of pharmacological, cellular and gene therapies. Duchenne Muscular Dystrophy will be essential reading not only for scientists and clinicians, but will also appeal to therapists and other professionals involved in the care of patients with muscular dystrophy.

Muscular Dystrophy

Muscular Dystrophy
Author: Madhuri Hegde,Arunkanth Ankala
Publsiher: BoD – Books on Demand
Total Pages: 556
Release: 2012-05-09
ISBN 10: 9535106031
ISBN 13: 9789535106036
Language: EN, FR, DE, ES & NL

Muscular Dystrophy Book Review:

With more than 30 different types and subtypes known and many more yet to be classified and characterized, muscular dystrophy is a highly heterogeneous group of inherited neuromuscular disorders. This book provides a comprehensive overview of the various types of muscular dystrophies, genes associated with each subtype, disease diagnosis, management as well as available treatment options. Though each different type and subtype of muscular dystrophy is associated with a different causative gene, the majority of them have overlapping clinical presentations, making molecular diagnosis inevitable for both disease diagnosis as well as patient management. This book discusses the currently available diagnostic approaches that have revolutionized clinical research. Pathophysiology of the different muscular dystrophies, multifaceted functions of the involved genes as well as efforts towards diagnosis and effective patient management, are also discussed. Adding value to the book are the included reports on ongoing studies that show a promise for future therapeutic strategies.

Experimental Muscular Dystrophies in Animals

Experimental Muscular Dystrophies in Animals
Author: Ira Rockwood Telford,Lárus Einarson
Publsiher: Unknown
Total Pages: 250
Release: 1971
ISBN 10:
ISBN 13: UOM:39015003243808
Language: EN, FR, DE, ES & NL

Experimental Muscular Dystrophies in Animals Book Review:

Neurological Rehabilitation

Neurological Rehabilitation
Author: Percival H. Pangilinan,Joseph E. Hornyak
Publsiher: Elsevier Inc. Chapters
Total Pages: 680
Release: 2013-01-10
ISBN 10: 0128078294
ISBN 13: 9780128078297
Language: EN, FR, DE, ES & NL

Neurological Rehabilitation Book Review:

The muscular dystrophies (MD) are a heterogeneous group of inherited disorders characterized by findings on muscle biopsy. In general, they feature progressive muscle wasting and weakness. In addition to the musculoskeletal system, direct and indirect effects can be seen in a variety of organ systems. These issues create challenges in patients with MD for ambulation and mobility, self-care, pain, fatigue, and community involvement. Because of its progressive nature and wide variety of pathophysiological mechanisms, patients with MD require individualized rehabilitation care. This chapter reviews specific rehabilitation needs and treatment of patients with MD.

Neuromuscular Disorders of Infancy Childhood and Adolescence

Neuromuscular Disorders of Infancy  Childhood  and Adolescence
Author: Basil T. Darras,H. Royden Jones, Jr.,Monique M. Ryan,Darryl C. De Vivo
Publsiher: Elsevier
Total Pages: 1160
Release: 2014-12-03
ISBN 10: 0124171273
ISBN 13: 9780124171275
Language: EN, FR, DE, ES & NL

Neuromuscular Disorders of Infancy Childhood and Adolescence Book Review:

Neuromuscular disorders are diagnosed across the lifespan and create many challenges especially with infants, children and adolescents. This new edition of the definitive reference, edited by the established world renowned authorities on the science, diagnosis and treatment of neuromuscular disorders in childhood is a timely and needed resource for all clinicians and researchers studying neuromuscular disorders, especially in childhood. The Second Edition is completely revised to remain current with advances in the field and to insure this remains the standard reference for clinical neurologists and clinical research neurologists. The Second Edition retains comprehensive coverage while shortening the total chapter count to be an even more manageable and effective reference. Carefully revised new edition of the classic reference on neuromuscular disorders in infancy, childhood and adolescence. Definitive coverage of the basic science of neuromuscular disease and the latest diagnosis and treatment best practices. Includes coverage of clinical phenomenology, electrophysiology, histopathology, molecular genetics and protein chemistry