Multiscale Biomechanical Modeling of the Brain

Multiscale Biomechanical Modeling of the Brain
Author: Mark F. Horstemeyer,Raj K. Prabhu
Publsiher: Academic Press
Total Pages: 276
Release: 2021-10-27
ISBN 10: 0128181451
ISBN 13: 9780128181454
Language: EN, FR, DE, ES & NL

Multiscale Biomechanical Modeling of the Brain Book Review:

Multiscale Biomechanical Modeling of the Brain discusses the constitutive modeling of the brain at various length scales (nanoscale, microscale, mesoscale, macroscale and structural scale). In each scale, the book describes the state-of-the- experimental and computational tools used to quantify critical deformational information at each length scale. Then, at the structural scale, several user-based constitutive material models are presented, along with real-world boundary value problems. Lastly, design and optimization concepts are presented for use in occupant-centric design frameworks. This book is useful for both academia and industry applications that cover basic science aspects or applied research in head and brain protection. The multiscale approach to this topic is unique, and not found in other books. It includes meticulously selected materials that aim to connect the mechanistic analysis of the brain tissue at size scales ranging from subcellular to organ levels. Presents concepts in a theoretical and thermodynamic framework for each length scale Teaches readers not only how to use an existing multiscale model for each brain but also how to develop a new multiscale model Takes an integrated experimental-computational approach and gives structured multiscale coverage of the problems

Biomechanical Analysis of Blast induced Traumatic Brain Injury Using Multiscale Brain Modeling

Biomechanical Analysis of Blast induced Traumatic Brain Injury Using Multiscale Brain Modeling
Author: Mahdi Sotudeh Chafi
Publsiher: Unknown
Total Pages: 408
Release: 2009
ISBN 10: 1928374650XXX
ISBN 13: OCLC:437257621
Language: EN, FR, DE, ES & NL

Biomechanical Analysis of Blast induced Traumatic Brain Injury Using Multiscale Brain Modeling Book Review:

Multiscale Modeling in Biomechanics and Mechanobiology

Multiscale Modeling in Biomechanics and Mechanobiology
Author: Suvranu De,Wonmuk Hwang,Ellen Kuhl
Publsiher: Springer
Total Pages: 286
Release: 2014-10-10
ISBN 10: 1447165993
ISBN 13: 9781447165996
Language: EN, FR, DE, ES & NL

Multiscale Modeling in Biomechanics and Mechanobiology Book Review:

Presenting a state-of-the-art overview of theoretical and computational models that link characteristic biomechanical phenomena, this book provides guidelines and examples for creating multiscale models in representative systems and organisms. It develops the reader's understanding of and intuition for multiscale phenomena in biomechanics and mechanobiology, and introduces a mathematical framework and computational techniques paramount to creating predictive multiscale models. Biomechanics involves the study of the interactions of physical forces with biological systems at all scales – including molecular, cellular, tissue and organ scales. The emerging field of mechanobiology focuses on the way that cells produce and respond to mechanical forces – bridging the science of mechanics with the disciplines of genetics and molecular biology. Linking disparate spatial and temporal scales using computational techniques is emerging as a key concept in investigating some of the complex problems underlying these disciplines. Providing an invaluable field manual for graduate students and researchers of theoretical and computational modelling in biology, this book is also intended for readers interested in biomedical engineering, applied mechanics and mathematical biology.

Mathematical Modelling and Biomechanics of the Brain

Mathematical Modelling and Biomechanics of the Brain
Author: Corina Drapaca,Siv Sivaloganathan
Publsiher: Springer Nature
Total Pages: 155
Release: 2019-09-06
ISBN 10: 1493998102
ISBN 13: 9781493998104
Language: EN, FR, DE, ES & NL

Mathematical Modelling and Biomechanics of the Brain Book Review:

This monograph aims to provide a rigorous yet accessible presentation of some fundamental concepts used in modeling brain mechanics and give a glimpse of the insights and advances that have arisen as a result of the nascent interaction of the mathematical and neurosurgical sciences. It begins with some historical perspective and a brief synopsis of the biomedical/biological manifestations of the clinical conditions/diseases considered. Each chapter proceeds with a discussion of the various mathematical models of the problems considered, starting with the simplest models and proceeding to more complex models where necessary. A detailed list of relevant references is provided at the end of each chapter. With the beginning research student in mind, the chapters have been crafted to be as self-contained as possible while addressing different clinical conditions and diseases. The book is intended as a brief introduction to both theoreticians and experimentalists interested in brain mechanics, with directions and guidance for further reading, for those who wish to pursue particular topics in greater depth. It can also be used as a complementary textbook in a graduate level course for neuroscientists and neuroengineers.

Practical Aspects of Computational Chemistry

Practical Aspects of Computational Chemistry
Author: Jerzy Leszczynski,Manoj Shukla
Publsiher: Springer Science & Business Media
Total Pages: 465
Release: 2009-10-03
ISBN 10: 9048126878
ISBN 13: 9789048126873
Language: EN, FR, DE, ES & NL

Practical Aspects of Computational Chemistry Book Review:

"Practical Aspects of Computational Chemistry" presents contributions on a range of aspects of Computational Chemistry applied to a variety of research fields. The chapters focus on recent theoretical developments which have been used to investigate structures and properties of large systems with minimal computational resources. Studies include those in the gas phase, various solvents, various aspects of computational multiscale modeling, Monte Carlo simulations, chirality, the multiple minima problem for protein folding, the nature of binding in different species and dihydrogen bonds, carbon nanotubes and hydrogen storage, adsorption and decomposition of organophosphorus compounds, X-ray crystallography, proton transfer, structure-activity relationships, a description of the REACH programs of the European Union for chemical regulatory purposes, reactions of nucleic acid bases with endogenous and exogenous reactive oxygen species and different aspects of nucleic acid bases, base pairs and base tetrads.

Seeing Beyond the Eye The Brain Connection

Seeing Beyond the Eye  The Brain Connection
Author: Christine Nguyen,Monica Liliana Acosta,Silvia Di Angelantonio,Thomas Salt
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2021-09-02
ISBN 10: 2889712591
ISBN 13: 9782889712595
Language: EN, FR, DE, ES & NL

Seeing Beyond the Eye The Brain Connection Book Review:

Computer Methods in Biomechanics and Biomedical Engineering

Computer Methods in Biomechanics and Biomedical Engineering
Author: Amit Gefen,Daphne Weihs
Publsiher: Springer
Total Pages: 263
Release: 2017-08-29
ISBN 10: 3319597647
ISBN 13: 9783319597645
Language: EN, FR, DE, ES & NL

Computer Methods in Biomechanics and Biomedical Engineering Book Review:

This edited volume collects the research results presented at the 14th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering, Tel Aviv, Israel, 2016. The topical focus includes, but is not limited to, cardiovascular fluid dynamics, computer modeling of tissue engineering, skin and spine biomechanics, as well as biomedical image analysis and processing. The target audience primarily comprises research experts in the field of bioengineering, but the book may also be beneficial for graduate students alike.

Tumors of the Central Nervous System Volume 12

Tumors of the Central Nervous System  Volume 12
Author: M.A. Hayat
Publsiher: Springer Science & Business Media
Total Pages: 386
Release: 2013-11-12
ISBN 10: 9400772173
ISBN 13: 9789400772175
Language: EN, FR, DE, ES & NL

Tumors of the Central Nervous System Volume 12 Book Review:

As in the case of its eleven predecessors in the series Tumors of the Central Nervous System, this volume is distinguished for its thorough approach, its roster of 92 distinguished contributors representing 11 different countries and its detailed examination of leading-edge technology and methods. Volume 12: Molecular Mechanisms, Children’s Cancer, Treatments, and Radiosurgery offers a comprehensive review of the diagnosis, therapy and prognosis of brain and spinal cord tumors. Coverage extends to a large number of tumor types, including neuroblastoma, medulloblastoma, meningioma and chordoma. Molecular profiling of brain tumors to select appropriate therapy in clinical trials of brain tumors is discussed in detail, as is the classification/diagnosis of brain tumors based on function analysis. CDK6 as the molecular regulator of neuronal differentiation in the adult brain, and the role of aquaporins in human brain tumor growth are explained. Discussion also includes tumors affecting children, including neuroblastoma and medulloblastoma. A full chapter is devoted to the role of molecular genetic alterations in medulloblastoma, and another examines survival differences between children and adults with medulloblastoma. The use of various types of imaging methods to diagnose brain tumors is explained. In-depth discussion of treatment options includes stereotactic radiosurgery, endoscopic neurosurgery, electrochemotherapy, transsphenoidal surgery, focal ablation, whole brain radiation therapy and recraniotomy.

Biomechanics of the Cerebrum at Finite Strain

Biomechanics of the Cerebrum at Finite Strain
Author: Thibault Philippe Prévost
Publsiher: Unknown
Total Pages: 124
Release: 2010
ISBN 10: 1928374650XXX
ISBN 13: OCLC:1011525900
Language: EN, FR, DE, ES & NL

Biomechanics of the Cerebrum at Finite Strain Book Review:

The present study addresses the large strain nonlinear mechanical response of the cerebral cortex at the macroscopic tissue level and at the microscopic cell level. Unconfined uniaxial compression tests were conducted in vitro on cortical samples of porcine brains. The tests consisted of load-unload and relaxation segments to 50% nominal deformation at 0.01 to 10 s-1 strain rates. The tissue exhibited moderate volumetric compressibility, marked hysteretic features, and substantial nonlinearities. Indentation tests - with displacement histories mirroring those imposed in compression - were performed on the cortex of porcine brains in vivo, in situ and in vitro, in order to assess and contrast the mechanical properties of the live and dead tissue. The tissue response shared similar qualitative nonlinear viscoelastic features under all testing conditions, although, quantitatively, the response was found to be significantly stiffer in situ than in vivo. Test protocols were also developed at the neuronal cell level using atomic force microscopy. The response of individual somata to cyclic load-unload and relaxation test sequences was found to be nonlinear with time dependencies and hysteretic patterns similar to those measured at the tissue level. A large strain kinematics nonlinear continuum model was proposed to capture the features of the tissue and cell responses. The model was numerically implemented into a three-dimensional finite-element framework. The continuum formulation was found to successfully account for the main experimental observations gathered in vitro at the tissue and cell levels. The present study provides novel insights into the tissue rheology in vivo, in situ and in vitro, at large strains, in the quasi-static and dynamic strain rate regime and reports the first body of observations on the large strain nonlinear viscoelastic properties of brain tissue in vivo. These observations could be directly compared to those pertaining to the tissue response in situ and in vitro, thereby providing a unique quantitative basis for further refinements of existing biomechanical models relying only on in vitro/situ measurements. The consistent set of mechanical data collected, and the constitutive framework proposed at the tissue and cell levels might support the development of multiscale numerical models to study traumatic brain injury.

Multiscale Modeling of Cancer

Multiscale Modeling of Cancer
Author: Vittorio Cristini,John Lowengrub
Publsiher: Cambridge University Press
Total Pages: 135
Release: 2010-09-09
ISBN 10: 1139491504
ISBN 13: 9781139491501
Language: EN, FR, DE, ES & NL

Multiscale Modeling of Cancer Book Review:

Mathematical modeling, analysis and simulation are set to play crucial roles in explaining tumor behavior, and the uncontrolled growth of cancer cells over multiple time and spatial scales. This book, the first to integrate state-of-the-art numerical techniques with experimental data, provides an in-depth assessment of tumor cell modeling at multiple scales. The first part of the text presents a detailed biological background with an examination of single-phase and multi-phase continuum tumor modeling, discrete cell modeling, and hybrid continuum-discrete modeling. In the final two chapters, the authors guide the reader through problem-based illustrations and case studies of brain and breast cancer, to demonstrate the future potential of modeling in cancer research. This book has wide interdisciplinary appeal and is a valuable resource for mathematical biologists, biomedical engineers and clinical cancer research communities wishing to understand this emerging field.

Military Injury Biomechanics

Military Injury Biomechanics
Author: Melanie Franklyn,Peter Vee Sin Lee
Publsiher: CRC Press
Total Pages: 418
Release: 2017-06-12
ISBN 10: 1498742831
ISBN 13: 9781498742832
Language: EN, FR, DE, ES & NL

Military Injury Biomechanics Book Review:

Military Injury Biomechanics: The Cause and Prevention of Impact Injuries is a reference manual where information and data from a large number of sources, focussing on injuries related to military events, has been critically reviewed and discussed. The book covers the cause and prevention of impact injuries to all the major body regions, while topics such as the historical background of military impact biomechanics, the history and use of anthropomorphic test devices for military applications and the medical management of injuries are also discussed. An international team of experts have been brought together to examine and review the topics. The book is intended for researchers, postgraduate students and others working or studying defence and impact injuries.

Computer Models in Biomechanics

Computer Models in Biomechanics
Author: Gerhard A. Holzapfel,Ellen Kuhl
Publsiher: Springer Science & Business Media
Total Pages: 416
Release: 2012-10-16
ISBN 10: 9400754647
ISBN 13: 9789400754645
Language: EN, FR, DE, ES & NL

Computer Models in Biomechanics Book Review:

This book contains a collection of papers that were presented at the IUTAM Symposium on “Computer Models in Biomechanics: From Nano to Macro” held at Stanford University, California, USA, from August 29 to September 2, 2011. It contains state-of-the-art papers on: - Protein and Cell Mechanics: coarse-grained model for unfolded proteins, collagen-proteoglycan structural interactions in the cornea, simulations of cell behavior on substrates - Muscle Mechanics: modeling approaches for Ca2+–regulated smooth muscle contraction, smooth muscle modeling using continuum thermodynamical frameworks, cross-bridge model describing the mechanoenergetics of actomyosin interaction, multiscale skeletal muscle modeling - Cardiovascular Mechanics: multiscale modeling of arterial adaptations by incorporating molecular mechanisms, cardiovascular tissue damage, dissection properties of aortic aneurysms, intracranial aneurysms, electromechanics of the heart, hemodynamic alterations associated with arterial remodeling following aortic coarctation, patient-specific surgery planning for the Fontan procedure - Multiphasic Models: solutes in hydrated biological tissues, reformulation of mixture theory-based poroelasticity for interstitial tissue growth, tumor therapies of brain tissue, remodeling of microcirculation in liver lobes, reactions, mass transport and mechanics of tumor growth, water transport modeling in the brain, crack modeling of swelling porous media - Morphogenesis, Biological Tissues and Organs: mechanisms of brain morphogenesis, micromechanical modeling of anterior cruciate ligaments, mechanical characterization of the human liver, in vivo validation of predictive models for bone remodeling and mechanobiology, bridging scales in respiratory mechanics

Computational Biomechanics for Medicine

Computational Biomechanics for Medicine
Author: Poul M.F. Nielsen,Adam Wittek,Karol Miller
Publsiher: Springer Science & Business Media
Total Pages: 140
Release: 2012-05-02
ISBN 10: 1461431727
ISBN 13: 9781461431725
Language: EN, FR, DE, ES & NL

Computational Biomechanics for Medicine Book Review:

One of the greatest challenges for mechanical engineers is to extend the success of computational mechanics to fields outside traditional engineering, in particular to biology, biomedical sciences, and medicine. This book is an opportunity for computational biomechanics specialists to present and exchange opinions on the opportunities of applying their techniques to computer-integrated medicine. Computational Biomechanics for Medicine: Deformation and Flow collects the papers from the Medical Image Computing and Computer Assisted Intervention conference (MICCAI 2011) dedicated to research in the field of medical image computing and computer assisted medical interventions. The topics covered include: medical image analysis, image-guided surgery, surgical simulation, surgical intervention planning, disease prognosis and diagnostics, injury mechanism analysis, implant and prostheses design, and medical robotics.

Image Guided Interventions

Image Guided Interventions
Author: Terry Peters,Kevin Cleary
Publsiher: Springer Science & Business Media
Total Pages: 557
Release: 2008-05-21
ISBN 10: 0387738584
ISBN 13: 9780387738581
Language: EN, FR, DE, ES & NL

Image Guided Interventions Book Review:

Responding to the growing demand for minimally invasive procedures, this book provides a comprehensive overview of the current technological advances in image-guided surgery. It blends the expertise of both engineers and physicians, offering the latest findings and applications. Detailed color images guide readers through the latest techniques, including cranial, orthopedic, prostrate, and endovascular interventions.

Clinical Image Based Procedures Translational Research in Medical Imaging

Clinical Image Based Procedures  Translational Research in Medical Imaging
Author: Cristina Oyarzun Laura,Raj Shekhar,Stefan Wesarg,Miguel Ángel González Ballester,Klaus Drechsler,Yoshinobu Sato,Marius Erdt,Marius George Linguraru
Publsiher: Springer
Total Pages: 132
Release: 2016-03-29
ISBN 10: 331931808X
ISBN 13: 9783319318080
Language: EN, FR, DE, ES & NL

Clinical Image Based Procedures Translational Research in Medical Imaging Book Review:

This book constitutes revised selected papers from the 4th International Workshop on Clinical Image-Based Procedures, CLIP 2015, held in conjunction with MICCAI 2015 in Munich, Germany, in October 2015. The 15 papers presented in this volume were carefully reviewed and selected from 22 submissions. CLIP focuses on translational research; therefore, the goal of the works presented in this workshop is to bring basic research methods closer to the clinical practice. A highlight of this workshop is the subject of strategies for personalized medicine to enhance diagnosis, treatment and interventions.

Brainlesion Glioma Multiple Sclerosis Stroke and Traumatic Brain Injuries

Brainlesion  Glioma  Multiple Sclerosis  Stroke and Traumatic Brain Injuries
Author: Alessandro Crimi,Spyridon Bakas
Publsiher: Springer Nature
Total Pages: 529
Release: 2021-03-26
ISBN 10: 3030720845
ISBN 13: 9783030720841
Language: EN, FR, DE, ES & NL

Brainlesion Glioma Multiple Sclerosis Stroke and Traumatic Brain Injuries Book Review:

This two-volume set LNCS 12658 and 12659 constitutes the thoroughly refereed proceedings of the 6th International MICCAI Brainlesion Workshop, BrainLes 2020, the International Multimodal Brain Tumor Segmentation (BraTS) challenge, and the Computational Precision Medicine: Radiology-Pathology Challenge on Brain Tumor Classification (CPM-RadPath) challenge. These were held jointly at the 23rd Medical Image Computing for Computer Assisted Intervention Conference, MICCAI 2020, in Lima, Peru, in October 2020.* The revised selected papers presented in these volumes were organized in the following topical sections: brain lesion image analysis (16 selected papers from 21 submissions); brain tumor image segmentation (69 selected papers from 75 submissions); and computational precision medicine: radiology-pathology challenge on brain tumor classification (6 selected papers from 6 submissions). *The workshop and challenges were held virtually.

Combining Simulations Theory and Experiments into Multiscale Models of Biological Events

Combining Simulations  Theory  and Experiments into Multiscale Models of Biological Events
Author: Fabio Trovato,Peter J. Bond,Joanna Trylska,Peter Guy Wolynes
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2022-01-11
ISBN 10: 2889740250
ISBN 13: 9782889740253
Language: EN, FR, DE, ES & NL

Combining Simulations Theory and Experiments into Multiscale Models of Biological Events Book Review:

Concussive Brain Trauma

Concussive Brain Trauma
Author: Rolland S. Parker
Publsiher: CRC Press
Total Pages: 879
Release: 2011-09-20
ISBN 10: 0849380391
ISBN 13: 9780849380396
Language: EN, FR, DE, ES & NL

Concussive Brain Trauma Book Review:

Focusing on a public health problem affecting millions of people of all ages, the second edition of Concussive Brain Trauma: Neurobehavioral Impairment and Maladaptation reflects Dr. Rolland S. Parker's more than 25 years of neuropsychological practice and research in traumatic brain injury and stress, and his prior experience as a clinical psychologist. Unique in its coverage of the personality changes, family dysfunction, and stress that often occur in the wake of concussive brain trauma, this book uses case examples to illustrate persistent and acute alterations of consciousness, as well as cognitive, mood, personality, and social effects of head injury in order to guide appropriate treatment. With six additional chapters, this edition covers: Post-concussive syndrome, biomechanical causes of trauma, and acute and chronic phases of co-morbid brain and somatic injury The physiological basis for behavior and posttraumatic dysregulation of systems Disorders related to pain, sensation, and motor activities Headaches, consciousness, cognition, cerebral personality, and psychodynamic disorders Developmental effects of children's concussive injury Blast injuries characteristic of modern war Unfamiliar signs not included in the usual list of post-concussive symptoms With a firm multi-disciplinary foundation, this book aids the concerned practitioner in rendering a more complete and accurate assessment, recognizing gaps in prior documentation, and conducting a more complete examination to acquire omitted information. It also shows how to achieve the benefit of higher accuracy in assessing disability, planning rehabilitation, and offering compensation. The book stands alone as an in-depth, authoritative guide to closed head injury and traumatic brain injury.

Biomechanical Principles and Applications in Sports

Biomechanical Principles and Applications in Sports
Author: Jani Macari Pallis,Jill L. McNitt-Gray,George K. Hung
Publsiher: Springer Nature
Total Pages: 321
Release: 2019-09-11
ISBN 10: 3030134679
ISBN 13: 9783030134679
Language: EN, FR, DE, ES & NL

Biomechanical Principles and Applications in Sports Book Review:

This book provides an overview of biomedical applications in sports, including reviews of the current state-of-the art methodologies and research areas. Basic principles with specific case studies from different types of sports as well as suggested student activities and homework problems are included. Equipment design and manufacturing, quantitative evaluation methods, and sports medicine are given special focus. Biomechanical Principles and Applications in Sports can be used as a textbook in a sports technology or sports engineering program, and is also ideal for graduate students and researchers in biomedical engineering, physics, and sports physiology. It can also serve as a useful reference for professional athletes and coaches interested in gaining a deeper understanding of biomechanics and exercise physiology to improve athletic performance.

Handbook of Imaging in Biological Mechanics

Handbook of Imaging in Biological Mechanics
Author: Corey P. Neu,Guy M. Genin
Publsiher: CRC Press
Total Pages: 579
Release: 2014-10-24
ISBN 10: 1466588144
ISBN 13: 9781466588141
Language: EN, FR, DE, ES & NL

Handbook of Imaging in Biological Mechanics Book Review:

Emerging imaging techniques have opened new fronts to investigate tissues, cells, and proteins. Transformative technologies such as microCT scans, super-resolution microscopy, fluorescence-based tools, and other methods now allow us to study the mechanics of cancer, dissect the origins of cellular force regulation, and examine biological specimens