Essentials of Stem Cell Biology

Essentials of Stem Cell Biology
Author: Robert Lanza,John Gearhart,Brigid Hogan,Douglas Melton,Roger Pedersen,E. Donnall Thomas,James A. Thomson,Ian Sir Wilmut
Publsiher: Academic Press
Total Pages: 680
Release: 2009-06-05
ISBN 10: 9780080884974
ISBN 13: 0080884970
Language: EN, FR, DE, ES & NL

Essentials of Stem Cell Biology Book Review:

First developed as an accessible abridgement of the successful Handbook of Stem Cells, Essentials of Stem Cell Biology serves the needs of the evolving population of scientists, researchers, practitioners and students that are embracing the latest advances in stem cells. Representing the combined effort of seven editors and more than 200 scholars and scientists whose pioneering work has defined our understanding of stem cells, this book combines the prerequisites for a general understanding of adult and embryonic stem cells with a presentation by the world's experts of the latest research information about specific organ systems. From basic biology/mechanisms, early development, ectoderm, mesoderm, endoderm, methods to application of stem cells to specific human diseases, regulation and ethics, and patient perspectives, no topic in the field of stem cells is left uncovered. Selected for inclusion in Doody's Core Titles 2013, an essential collection development tool for health sciences libraries Contributions by Nobel Laureates and leading international investigators Includes two entirely new chapters devoted exclusively to induced pluripotent stem (iPS) cells written by the scientists who made the breakthrough Edited by a world-renowned author and researcher to present a complete story of stem cells in research, in application, and as the subject of political debate Presented in full color with glossary, highlighted terms, and bibliographic entries replacing references

Research Awards Index

Research Awards Index
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 1981
ISBN 10:
ISBN 13: STANFORD:36105119624695
Language: EN, FR, DE, ES & NL

Research Awards Index Book Review:

Stem Cells

Stem Cells
Author: Christine Mummery,Anja van de Stolpe,Bernard Roelen,Hans Clevers
Publsiher: Academic Press
Total Pages: 448
Release: 2014-05-23
ISBN 10: 0124115675
ISBN 13: 9780124115675
Language: EN, FR, DE, ES & NL

Stem Cells Book Review:

The second edition of Stem Cells: Scientific Facts and Fiction provides the non-stem cell expert with an understandable review of the history, current state of affairs, and facts and fiction of the promises of stem cells. Building on success of its award-winning preceding edition, the second edition features new chapters on embryonic and iPS cells and stem cells in veterinary science and medicine. It contains major revisions on cancer stem cells to include new culture models, additional interviews with leaders in progenitor cells, engineered eye tissue, and xeno organs from stem cells, as well as new information on "organs on chips" and adult progenitor cells. In the past decades our understanding of stem cell biology has increased tremendously. Many types of stem cells have been discovered in tissues that everyone presumed were unable to regenerate in adults, the heart and the brain in particular. There is vast interest in stem cells from biologists and clinicians who see the potential for regenerative medicine and future treatments for chronic diseases like Parkinson's, diabetes, and spinal cord lesions, based on the use of stem cells; and from entrepreneurs in biotechnology who expect new commercial applications ranging from drug discovery to transplantation therapies. Explains in straightforward, non-specialist language the basic biology of stem cells and their applications in modern medicine and future therapy Includes extensive coverage of adult and embryonic stem cells both historically and in contemporary practice Richly illustrated to assist in understanding how research is done and the current hurdles to clinical practice

Deep Brain Stimulation for Parkinson s Disease

Deep Brain Stimulation for Parkinson s Disease
Author: Gordon H. Baltuch,Matthew B. Stern
Publsiher: CRC Press
Total Pages: 372
Release: 2007-03-19
ISBN 10: 9781420019759
ISBN 13: 1420019759
Language: EN, FR, DE, ES & NL

Deep Brain Stimulation for Parkinson s Disease Book Review:

Considered the largest breakthrough in the treatment of Parkinson's disease in the past 40 years, Deep Brain Stimulation (DBS) is a pioneering procedure of neurology and functional neurosurgery, forging enormous change and growth within the field. The first comprehensive text devoted to this surgical therapy, Deep Brain Stimulation for Parkinson's

Stromal Cells

Stromal Cells
Author: Mani T. Valarmathi
Publsiher: BoD – Books on Demand
Total Pages: 260
Release: 2019-01-23
ISBN 10: 1789849845
ISBN 13: 9781789849844
Language: EN, FR, DE, ES & NL

Stromal Cells Book Review:

Stromal cells are connective tissue cells of any organ, and they support the function of the parenchymal cells of that particular organ. Stromal/stromal stem cells are fundamentally a heterogeneous population of cells with contradictory differentiation potential depending upon their environmental niche. Stromal cell biology is not only intriguing, but equally stromal cell ontogeny in vivo remains challenging. In recent years there has been substantial advances in our understanding of stromal cell biology, especially stromal cell isolation, characterization, differentiation, and interactions in physiological (epithelial-stromal interactions) as well as pathophysiological (stromal-cancer interactions) contexts. In addition, stromal cells are also utilized more and more as a therapeutic tool not only in the field of gene therapy but also in the translational field of tissue engineering and regenerative medicine. Therefore, the goal of this book is to consolidate the recent advances in the area of stromal/stromal stem cell biology covering a broad range of interrelated topics in a timely fashion and to disseminate that knowledge in a lucid way to a greater scientific audience. This book will prove highly useful for students, researchers, and clinicians in stem cell biology, developmental biology, cancer biology, pathology, oncology, as well as tissue engineering and regenerative medicine. This quick reference will benefit anyone desiring a thorough overview of stromal cell structure, function, and its therapeutic implications.

MBC

MBC
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 2003
ISBN 10:
ISBN 13: STANFORD:36105114027167
Language: EN, FR, DE, ES & NL

MBC Book Review:

Pluripotent Stem Cells

Pluripotent Stem Cells
Author: Deepa Bhartiya,Nibedita Lenka
Publsiher: BoD – Books on Demand
Total Pages: 640
Release: 2013-08-28
ISBN 10: 9535111922
ISBN 13: 9789535111924
Language: EN, FR, DE, ES & NL

Pluripotent Stem Cells Book Review:

Stem cells have generated a lot of excitement among the researchers, clinicians and the public alike. Various types of stem cells are being evaluated for their regenerative potential. Marginal benefit resulting by transplanting autologus stem cells (deemed to be absolutely safe) in various clinical conditions has been proposed to be a growth factor effect rather than true regeneration. In contrast, various pre-clinical studies have been undertaken, using differentiated cells from embryonic stem cells or induced pluripotent stem cells have shown promise, functional improvement and no signs of teratoma formation. The scientists are not in a rush to reach the clinic but a handful of clinical studies have shown promise. This book is a collection of studies/reviews, beginning with an introduction to the pluripotent stem cells and covering various aspects like derivation, differentiation, ethics, etc., and hence would provide insight into the recent standing on the pluripotent stem cells biology. The chapters have been categorized into three sections, covering subjects ranging from the generation of pluripotent stem cells and various means of their derivation from embryonic as well as adult tissues, the mechanistic understanding of pluripotency and narrating the potential therapeutic implications of these in vitro generated cells in various diseases, in addition to the associated pros and cons in the same.

Stem Cell Biology and Tissue Engineering in Dental Sciences

Stem Cell Biology and Tissue Engineering in Dental Sciences
Author: Ajaykumar Vishwakarma,Paul Sharpe,Songtao Shi,Murugan Ramalingam
Publsiher: Academic Press
Total Pages: 932
Release: 2014-11-05
ISBN 10: 0123977789
ISBN 13: 9780123977786
Language: EN, FR, DE, ES & NL

Stem Cell Biology and Tissue Engineering in Dental Sciences Book Review:

Stem Cell Biology and Tissue Engineering in Dental Sciences bridges the gap left by many tissue engineering and stem cell biology titles to highlight the significance of translational research in this field in the medical sciences. It compiles basic developmental biology with keen focus on cell and matrix biology, stem cells with relevance to tissue engineering biomaterials including nanotechnology and current applications in various disciplines of dental sciences; viz., periodontology, endodontics, oral & craniofacial surgery, dental implantology, orthodontics & dentofacial orthopedics, organ engineering and transplant medicine. In addition, it covers research ethics, laws and industrial pitfalls that are of particular importance for the future production of tissue constructs. Tissue Engineering is an interdisciplinary field of biomedical research, which combines life, engineering and materials sciences, to progress the maintenance, repair and replacement of diseased and damaged tissues. This ever-emerging area of research applies an understanding of normal tissue physiology to develop novel biomaterial, acellular and cell-based technologies for clinical and non-clinical applications. As evident in numerous medical disciplines, tissue engineering strategies are now being increasingly developed and evaluated as potential routine therapies for oral and craniofacial tissue repair and regeneration. Diligently covers all the aspects related to stem cell biology and tissue engineering in dental sciences: basic science, research, clinical application and commercialization Provides detailed descriptions of new, modern technologies, fabrication techniques employed in the fields of stem cells, biomaterials and tissue engineering research including details of latest advances in nanotechnology Includes a description of stem cell biology with details focused on oral and craniofacial stem cells and their potential research application throughout medicine Print book is available and black and white, and the ebook is in full color

Chemical Abstracts

Chemical Abstracts
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 2002
ISBN 10:
ISBN 13: UOM:39015057321351
Language: EN, FR, DE, ES & NL

Chemical Abstracts Book Review:

Forum

Forum
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 1997
ISBN 10:
ISBN 13: UCLA:L0078727922
Language: EN, FR, DE, ES & NL

Forum Book Review:

MicroRNA in Regenerative Medicine

MicroRNA in Regenerative Medicine
Author: Chandan K. Sen
Publsiher: Elsevier
Total Pages: 1288
Release: 2014-11-26
ISBN 10: 0124058582
ISBN 13: 9780124058583
Language: EN, FR, DE, ES & NL

MicroRNA in Regenerative Medicine Book Review:

This work encapsulates the uses of miRNA across stem cells, developmental biology, tissue injury and tissue regeneration. In particular contributors provide focused coverage of methodologies, intervention and tissue engineering. Regulating virtually all biological processes, the genome’s 1048 encoded microRNAs appear to hold considerable promise for the potential repair and regeneration of tissues and organs in future therapies. In this work, 50 experts address key topics of this fast-emerging field. Concisely summarizing and evaluating key findings emerging from fundamental research into translational application, they point to the current and future significance of clinical research in the miRNA area. Coverage encompasses all major aspects of fundamental stem cell and developmental biology, including the uses of miRNA across repair and regeneration, and special coverage of methodologies and interventions as they point towards organ and tissue engineering Multi-colour text layout with 150 colour figures to illustrate important findings Take home messages encapsulate key lessons throughout text Short chapters offer focused discussion and clear ‘voice’

Hematopoietic Cell Differentiation

Hematopoietic Cell Differentiation
Author: David W. Golde
Publsiher: Unknown
Total Pages: 504
Release: 1978
ISBN 10:
ISBN 13: UOM:39015000282155
Language: EN, FR, DE, ES & NL

Hematopoietic Cell Differentiation Book Review:

Imaging and monitoring astrocytes in health and disease

Imaging and monitoring astrocytes in health and disease
Author: Carole Escartin, Keith Murai
Publsiher: Frontiers Media SA
Total Pages: 329
Release: 2014-11-25
ISBN 10: 2889193934
ISBN 13: 9782889193936
Language: EN, FR, DE, ES & NL

Imaging and monitoring astrocytes in health and disease Book Review:

Astrocytes are key cellular partners to neurons in the brain. They play an important role in multiple processes such as neurotransmitter recycling, trophic support, antioxidant defense, ionic homeostasis, inflammatory modulation, neurovascular and neurometabolic coupling, neurogenesis, synapse formation and synaptic plasticity. In addition to their crucial involvement in normal brain physiology, it is well known that astrocytes adopt a reactive phenotype under most acute and chronic pathological conditions such as ischemia, trauma, brain cancer, epilepsy, demyelinating and neurodegenerative diseases. However, the functional impact of astrocyte reactivity is still unclear. During the last decades, the development of innovative approaches to study astrocytes has significantly improved our understanding of their prominent role in brain function and their contribution to disease states. In particular, new genetic tools, molecular probes, and imaging techniques that achieve high spatial and temporal resolution have revealed new insight into astrocyte functions in situ. This Research Topic provides a collection of cutting-edge techniques, approaches and models to study astrocytes in health and disease. It also suggests new directions to achieve discoveries on these fascinating cells.

Stem Cells and Biomaterials for Regenerative Medicine

Stem Cells and Biomaterials for Regenerative Medicine
Author: Marek J. Los,Andrzej Hudecki,Emilia Wiechec
Publsiher: Academic Press
Total Pages: 249
Release: 2018-11-07
ISBN 10: 0128122781
ISBN 13: 9780128122785
Language: EN, FR, DE, ES & NL

Stem Cells and Biomaterials for Regenerative Medicine Book Review:

Stem Cells and Biomaterials for Regenerative Medicine addresses the urgent need for a compact source of information on both the cellular and biomaterial aspects of regenerative medicine. By developing a mutual understanding between three separately functioning areas of science—medicine, the latest technology, and clinical economics—the volume encourages interdisciplinary relationships that will lead to solutions for the significant challenges faced by today's regenerative medicine. Users will find sections on the homeostatic balance created by apoptosis and proliferating tissue stem cells, the naturally regenerative capacities of various tissue types, the potential regenerative benefits of iPS-generation, various differentiation protocols, and more. Written in easily accessbile language, this volume is appropriate for any professional or medical staff looking to expand their knowledge with regard to stem cells and regenerative medicine. Arms readers with key information on tissue engineering, artificial organs and biomaterials, while using broadly accessible language Provides broad introduction to, and examples of, various types of stem cells, core concepts of regenerative medicine, biomaterials, nanotechnology and nanomaterials, somatic cell transdyferentiation, and more Edited and authored by researchers with expertise in regenerative medicine, (cancer) stem cells, biomaterials, genetics and nanomaterials

Stem Cells in Clinical Practice and Tissue Engineering

Stem Cells in Clinical Practice and Tissue Engineering
Author: Rakesh Sharma
Publsiher: BoD – Books on Demand
Total Pages: 352
Release: 2018-05-02
ISBN 10: 1789230101
ISBN 13: 9781789230109
Language: EN, FR, DE, ES & NL

Stem Cells in Clinical Practice and Tissue Engineering Book Review:

Stem Cells in Clinical Practice and Tissue Engineering is a concise book on applied methods of stem cell differentiation and optimization using tissue engineering methods. These methods offer immediate use in clinical regenerative medicine. The present volume will serve the purpose of applied stem cell differentiation optimization methods in clinical research projects, as well as be useful to relatively experienced stem cell scientists and clinicians who might wish to develop their stem cell clinical centers or research labs further. Chapters are arranged in the order of basic concepts of stem cell differentiation, clinical applications of pluripotent stem cells in skin, cardiac, bone, dental, obesity centers, followed by tissue engineering, new materials used, and overall evaluation with their permitted legal status.

CD23 a Novel Multifunctional Regulator of the Immune System that Binds IgE

CD23  a Novel Multifunctional Regulator of the Immune System that Binds IgE
Author: John Gordon
Publsiher: S Karger Ag
Total Pages: 208
Release: 1991
ISBN 10: 9783805553582
ISBN 13: 3805553587
Language: EN, FR, DE, ES & NL

CD23 a Novel Multifunctional Regulator of the Immune System that Binds IgE Book Review:

Multifunctional Role of Pancreatic Differentiation 2 PD2 in Pancreatic Cancer

Multifunctional Role of Pancreatic Differentiation 2  PD2  in Pancreatic Cancer
Author: Arokia Priyanka Vaz
Publsiher: Unknown
Total Pages: 486
Release: 2015
ISBN 10:
ISBN 13: OCLC:969346641
Language: EN, FR, DE, ES & NL

Multifunctional Role of Pancreatic Differentiation 2 PD2 in Pancreatic Cancer Book Review:

Cancer is a devastating disease that claims the lives of countless people due to its uncontrolled growth pattern. Among various cancers, pancreatic cancer is one of the most lethal cancers due to its aggressive nature, lack of early symptoms and resistance to chemotherapy. The molecular profile of this deadly malignancy is not completely understood. Malignancy arises due to loss or gain of function in genes involved in cell cycle progression leading to disruption of tightly regulated transitions. In addition the evolving concept of cancer throws light on a small population of cells within the tumor known as the cancer stem cells (CSCs) or tumor-initiating cells that are resistant to all drugs treatment and contributes towards tumor initiation and recurrence. Several studies have been carried out to identify specific markers for the cancer stem cell population including that of pancreatic cancer. Pancreatic Differentiation 2 (PD2) or human Polymerase Associated Factor 1 (hPaf1) is an important component of the multifunctional PAF1 complex initially identified to play a crucial role in transcriptional elongation of genes. During the last decade, several papers on PD2 showed that it is a multifaceted molecule playing roles in cell cycle regulation, stem cell maintenance, histone methylation, chromatin remodeling and acinar-to-ductal metaplasia. In this dissertation, the first goal was to investigate the role of PD2 in pancreatic cancer stem cells. Initially, we analyzed the expression and function of PD2 in pancreatic cancer stem cells isolated from pancreatic cancer cell lines, Kras (G12D); Pdx1 (Cre)(KC), Kras (G12D); Trp53 (R172H/+.); Pdx1(Cre) (KPC) mouse models and human pancreatic tumors. Furthermore, the expression of PD2 was significantly higher in CSCs isolated from pancreatic cancer cells along with CSC markers. These cells were shown to exhibit a cobblestone appearance, increased tumorsphere formation and significant tumor growth, characteristic of the CSC phenotype. interestingly, PD2 was found to be specifically overexpressed in a subpopulation of cells within mouse KC, KPC and human pancreatic tumors, which co-express CSC markers. The drug resistance property was impaired upon knockdown of PD2 with simultaneous alteration in the CSC phenotype and reduction in CD133 and MDR2 gene expression. Overall, my study identified that PD2 has a role in self-renewal and drug resistance of pancreatic CSCs. The second part of my dissertation was primarily focused at exploring the functional role of PD2 in pancreatic cancer cells. The ectopic overexpression of PD2 resulted in increased growth rate of tumor cells both in vitro and in vivo. Overexpression of PD2 led to increased growth, colony formation and migration. Interestingly, elevated expression of PD2 also increased the percentage of CSCs. Furthermore, in vivo studies revealed that PD2 overexpression leads to increased tumor volume and metastasis to distant secondary sites. These results were corroborated at the protein level where elevated expression of PD2 led to the up-regulation of c-Myc which is an important player in tumorigenesis and metastasis. In addition, the expression of PD2 in pancreatic cancer tissues and in vitro pancreatic progression model was elucidated. We demonstrated that the expression of PD2 was increased in the ducts present in the pancreatic cancer tissues when compared to the normal tissues. Likewise, the expression of PD2 was elevated in the transformed Human Pancreatic Nestin expressing (HPNE) cells when compared to the untransformed HPNE cells. Understanding the role of PD2 through cell lines led to my next aim to generate PD2 conditional knockout mice in order to substantiate our earlier work in cancer stem cells and acinar to ductal metaplasia during PC initiation. The animal model would be an important resource for understanding the role of PD2 in detail. Taken together, our findings demonstrate that PD2 is an essential member of the oncogene family that plays a significant role in facilitating drug resistance and cancer stem cell maintenance thereby acting as a positive regulator of cancer.

Mesenchymal Stromal Cells as Tumor Stromal Modulators

Mesenchymal Stromal Cells as Tumor Stromal Modulators
Author: Marcela Bolontrade,Mariana García
Publsiher: Academic Press
Total Pages: 642
Release: 2016-10-24
ISBN 10: 0128031034
ISBN 13: 9780128031032
Language: EN, FR, DE, ES & NL

Mesenchymal Stromal Cells as Tumor Stromal Modulators Book Review:

Mesenchymal stromal/ stem cells (MSCs) represent a heterogeneous cell population with immunomodulating, tissue repairing, differentiating, migratory and angiogenic abilities, making them important tools for clinical and translational research. An understanding of the role of MSCs in modulating tumor growth provides a glimpse into their role in non-pathological tissue remodeling and potential regenerative tissue therapies. Mesenchymal Stromal Cells as Tumor Stromal Modulators is a comprehensive source for the understanding of the role of MSCs as ubiquitous connective tissue cell components, which may have both direct and indirect effects on the tumor microenvironment and potential for regenerative therapeutics for various diseases. Using cancer as a model disease, this book explores the transformative role MSCs play in the recruitment of disease cells, cell repair and immunological defenses. Explores the biology of mesenchymal stromal cells (MSCs) and tissue related function Discusses the bidirectional communication between tumor stroma and MSCs derived from bone marrow, from adipose tissue and from other tissue types Provides in-depth analysis of the effects of MSCs on key processes that regulate disease progression, such as angiogenesis, metastatic potential, invasion, proliferation, tumor immune privileges

Translational Regenerative Medicine

Translational Regenerative Medicine
Author: Anthony Atala,Julie Allickson
Publsiher: Academic Press
Total Pages: 606
Release: 2014-12-01
ISBN 10: 0124104576
ISBN 13: 9780124104570
Language: EN, FR, DE, ES & NL

Translational Regenerative Medicine Book Review:

Translational Regenerative Medicine is a reference book that outlines the life cycle for effective implementation of discoveries in the dynamic field of regenerative medicine. By addressing science, technology, development, regulatory, manufacturing, intellectual property, investment, financial, and clinical aspects of the field, this work takes a holistic look at the translation of science and disseminates knowledge for practical use of regenerative medicine tools, therapeutics, and diagnostics. Incorporating contributions from leaders in the fields of translational science across academia, industry, and government, this book establishes a more fluid transition for rapid translation of research to enhance human health and well-being. Provides formulaic coverage of the landscape, process development, manufacturing, challenges, evaluation, and regulatory aspects of the most promising regenerative medicine clinical applications Covers clinical aspects of regenerative medicine related to skin, cartilage, tendons, ligaments, joints, bone, fat, muscle, vascular system, hematopoietic /immune system, peripheral nerve, central nervous system, endocrine system, ophthalmic system, auditory system, oral system, respiratory system, cardiac system, renal system, hepatic system, gastrointestinal system, genitourinary system Identifies effective, proven tools and metrics to identify and pursue clinical and commercial regenerative medicine

Inflammatory Bowel Disease

Inflammatory Bowel Disease
Author: Joseph B. Kirsner
Publsiher: W.B. Saunders Company
Total Pages: 800
Release: 2000
ISBN 10:
ISBN 13: UOM:39015048934429
Language: EN, FR, DE, ES & NL

Inflammatory Bowel Disease Book Review:

World-renowned experts present state-of-the-art information in the clinical understanding of inflammatory bowel disease in the 5th Edition of this best-selling text. Scholarly and pragmatic, this text features authoritative information on the medical and surgical management of IBD with the support of over 390 illustrations. Features many new chapters, including those covering intestinal permeability in health and disease, the intestinal response to acute inflammation and injuries, and current concepts of IBD etiology and pathogenesis.