Monoclonal Antibodies

Monoclonal Antibodies
Author: Steven Shire
Publsiher: Woodhead Publishing
Total Pages: 224
Release: 2015-04-24
ISBN 10: 0081002971
ISBN 13: 9780081002971
Language: EN, FR, DE, ES & NL

Monoclonal Antibodies Book Review:

Monoclonal antibodies (MAbs) are currently the major class of protein bio therapeutic being developed by biotechnology and pharmaceutical companies. Monoclonal Antibodies discusses the challenges and issues revolving around development of a monoclonal antibody produced by recombinant DNA technology into a therapeutic agent.This book covers downstream processing which includes design of processes to manufacture the formulation, formulation design, fill and finish into closure systems and routes of administration. The characterization of the final drug product is covered where the use of biophysical methods combined with genetic engineering is used to understand the solution properties of the formulation. The latter has become very important since many indications such as arthritis and asthma require the development of formulations for subcutaneous delivery (SC). The development of formulations for IV delivery is also important and comes with a different set of challenges. The challenges and strategies that can overcome these limitations are discussed in this book, starting with an introduction to these issues, followed by chapters detailing strategies to deal with them. Subsequent chapters explore the processing and storage of mAbs, development of delivery device technologies and conclude with a chapter on the future of mAbs in therapeutic remedies. Discusses the challenges to develop MAbs for intravenous (IV) and subcutaneous delivery (SC) Presents strategies to meet the challenges in development of MAbs for SC and IV administration Discusses the use of biophysical analytical tools coupled with MAb engineering to understand what governs MAb properties at high concentration

Monoclonal Antibody Production

Monoclonal Antibody Production
Author: National Research Council,Institute for Laboratory Animal Research,Committee on Methods of Producing Monoclonal Antibodies
Publsiher: National Academies Press
Total Pages: 74
Release: 1999-06-06
ISBN 10: 0309064473
ISBN 13: 9780309064477
Language: EN, FR, DE, ES & NL

Monoclonal Antibody Production Book Review:

The American Anti-Vivisection Society (AAVS) petitioned the National Institutes of Health (NIH) on April 23, 1997, to prohibit the use of animals in the production of mAb. On September 18, 1997, NIH declined to prohibit the use of mice in mAb production, stating that "the ascites method of mAb production is scientifically appropriate for some research projects and cannot be replaced." On March 26, 1998, AAVS submitted a second petition, stating that "NIH failed to provide valid scientific reasons for not supporting a proposed ban." The office of the NIH director asked the National Research Council to conduct a study of methods of producing mAb. In response to that request, the Research Council appointed the Committee on Methods of Producing Monoclonal Antibodies, to act on behalf of the Institute for Laboratory Animal Research of the Commission on Life Sciences, to conduct the study. The 11 expert members of the committee had extensive experience in biomedical research, laboratory animal medicine, animal welfare, pain research, and patient advocacy (Appendix B). The committee was asked to determine whether there was a scientific necessity for the mouse ascites method; if so, whether the method caused pain or distress; and, if so, what could be done to minimize the pain or distress. The committee was also asked to comment on available in vitro methods; to suggest what acceptable scientific rationale, if any, there was for using the mouse ascites method; and to identify regulatory requirements for the continued use of the mouse ascites method. The committee held an open data-gathering meeting during which its members summarized data bearing on those questions. A 1-day workshop (Appendix A) was attended by 34 participants, 14 of whom made formal presentations. A second meeting was held to finalize the report. The present report was written on the basis of information in the literature and information presented at the meeting and the workshop.

Monoclonal Antibodies

Monoclonal Antibodies
Author: James W. Goding
Publsiher: Unknown
Total Pages: 315
Release: 1986
ISBN 10:
ISBN 13: UOM:39015012462928
Language: EN, FR, DE, ES & NL

Monoclonal Antibodies Book Review:

This book represents the distillation and critical evaluation of many hundreds of publications relating to the production and use of antibodies. Therefore it is restricted to the "core" techniques of production and handling of antibodies, and their use in studies of antigen analysis, purification and localization.

Biosimilars of Monoclonal Antibodies

Biosimilars of Monoclonal Antibodies
Author: Cheng Liu,K. John Morrow
Publsiher: John Wiley & Sons
Total Pages: 704
Release: 2016-12-19
ISBN 10: 1118662318
ISBN 13: 9781118662311
Language: EN, FR, DE, ES & NL

Biosimilars of Monoclonal Antibodies Book Review:

Addressing a significant need by describing the science and process involved to develop biosimilars of monoclonal antibody (mAb) drugs, this book covers all aspects of biosimilar development: preclinical, clinical, regulatory, manufacturing. • Guides readers through the complex landscape involved with developing biosimilar versions of monoclonal antibody (mAb) drugs • Features flow charts, tables, and figures that clearly illustrate processes and makes the book comprehensible and accessible • Includes a review of FDA-approved mAb drugs as a quick reference to facts and useful information • Examines new technologies and strategies for improving biosimilar mAbs

The Pharmacology of Monoclonal Antibodies

The Pharmacology of Monoclonal Antibodies
Author: Martin Rosenberg,Gordon P. Moore
Publsiher: Springer Science & Business Media
Total Pages: 406
Release: 2012-12-06
ISBN 10: 3642784321
ISBN 13: 9783642784323
Language: EN, FR, DE, ES & NL

The Pharmacology of Monoclonal Antibodies Book Review:

A sample of the most exciting developments in the cloning, manipulation, expression and application of genetically-engineered monoclonal antibodies. This rapidly-evolving field has witnessed the PCR combinatorial cloning of vast immunological diversity, in vitro mutagenesis of MAbs, MAbs created by transgenic animals, novel expression systems in plants, animals and lower systems, as well as a rich variety of genetically modified MAbs as potential therapeutic agents. Leading scientists from academia and industry present their own findings as well as short reviews of these research areas.

Monoclonal Antibodies

Monoclonal Antibodies
Author: Thomas F. Kresina
Publsiher: CRC Press
Total Pages: 512
Release: 2020-08-27
ISBN 10: 100014741X
ISBN 13: 9781000147414
Language: EN, FR, DE, ES & NL

Monoclonal Antibodies Book Review:

Presents a sampling of new and novel approaches to the amelioration of musculoskeletal disease pathology, emphasizing prevention and therapy. Where applicable, these new technologies are focused on their application to human autoimmune diseases, but the volume mainly discusses and details the use of

Use of Monoclonal Antibodies in Conditioning Regimen in Transplantation

Use of Monoclonal Antibodies in Conditioning Regimen in Transplantation
Author: Pervin Topcuoglu
Publsiher: Unknown
Total Pages: 329
Release: 2015
ISBN 10:
ISBN 13: OCLC:1154212668
Language: EN, FR, DE, ES & NL

Use of Monoclonal Antibodies in Conditioning Regimen in Transplantation Book Review:

Monoclonal antibodies (MoAbs) alone or in the combination of conventional therapies have been used in the treatment of many benign or malign diseases. In the transplantation setting, Moabs have been generally applied as a part of conditioning regimen in the aims of the prevention of graft versus host disease and/or graft failure or treatment of underlying hematologic disease. The most frequent used moAbs for this purpose are rituximab, alemtuzumab, Gemtuzumab Ozogamicin or radioimmunoconjugates. In this chapter, we discussed the role of moAbs use in the conditioning regimens of allogeneic or autologous stem cell transplantation.

Monoclonal Antibodies in Diagnostic Immunohistochemistry

Monoclonal Antibodies in Diagnostic Immunohistochemistry
Author: Mark Wick
Publsiher: CRC Press
Total Pages: 664
Release: 1988-03-30
ISBN 10: 9780824778385
ISBN 13: 0824778383
Language: EN, FR, DE, ES & NL

Monoclonal Antibodies in Diagnostic Immunohistochemistry Book Review:

BRIEF OVERVIEW OF INTERMEDIATE FILAMENT PROTEINS -- NEUROFILAMENT PROTEINS -- GLIAL FILAMENT PROTEIN -- INTERPRETATION OF STUDIES OF HUMAN NERVOUS SYSTEM TUMORS USING ANTIBODIES TO NF AND GF PROTEINS -- FUTURE PROSPECTS FOR THE USE OF PROBES TO NF AND GF PROTEINS IN PATHOLOGY -- CONCLUSIONS -- APPENDIX: SPECIFICITY OF MONOCLONAL ANTIBODIES TO HUMAN NEUROFILAMENT AND GLIAL FILAMENT PROTEINS -- ACKNOWLEDGMENTS -- REFERENCES -- 6 Monoclonal Antibodies to Lymphorecticular and Myeloid Antigens -- METHODS UTILIZED WITH LYMPHOHEMATOPOIETIC MONOCLONAL ANTIBODIES -- T-CELL AND NATURAL KILLER CELL MONOCLONAL ANTIBODIES AND T-CELL MALIGNANCIES -- T-Cell Monoclonal Antibodies -- Natural Killer Cell Antibodies -- T-Cell Malignancies -- B-CELL MONOCLONAL ANTIBODIES AND B-CELL MALIGNANCIES -- B-Cell Monoclonal Antibodies -- B-Cell Malignancies -- Non-T Acute Lymphocytic Leukemia -- Small Noncleaved Cell Malignant Lymphoma -- Chronic Lymphocytic Leukemia and Small Lymphocytic Malignant Lymphoma -- Prolymphocytic Leukemia (Galton's Leukemia) -- Intermediate Differentiation Malignant Lymphoma -- Follicular Malignant Lymphoma with Small Cleaved and/or Large Cleaved Cells -- Diffuse Small Cleaved and Diffuse Mixed Small and Large Cell Malignant Lymphoma -- Diffuse Large Cell and Immunoblastic Malignant Lymphoma -- Hairy Cell Leukemia -- Multiple Myeloma and Plasmacytoid Lymphoma -- HODGKIN'S DISEASE -- MYELOID MONOCLONAL ANTIBODIES AND ACUTE AND CHRONIC MYELOID LEUKEMIA -- Myeloid Monoclonal Antibodies -- Acute Myeloid Leukemia -- Chronic Myelogenous Leukemia -- MONOCLONAL ANTIBODIES USED IN PARAFFIN-EMBEDDED SECTIONS -- Immunoglobulin -- Leu M1 -- LN-1 and LN-2 -- Leu 7 -- Others -- FUTURE DI RECTION -- REFERENCES -- 7 Monoclonal Antibodies to Human Milk Fat Globule Proteins

Therapeutic Monoclonal Antibodies

Therapeutic Monoclonal Antibodies
Author: Zhiqiang An
Publsiher: John Wiley & Sons
Total Pages: 896
Release: 2011-09-20
ISBN 10: 1118210263
ISBN 13: 9781118210260
Language: EN, FR, DE, ES & NL

Therapeutic Monoclonal Antibodies Book Review:

70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies. First book to address the discovery and development of antibody therapeutics in their entirety. Most chapters contain experimental data to illustrate the principles described in them. Authors provide detailed methodologies that readers can take away with them and use in their own laboratories.

Monoclonal Antibodies

Monoclonal Antibodies
Author: Philip Shepherd,Christopher J. Dean
Publsiher: Practical Approach (Paperback)
Total Pages: 479
Release: 2000
ISBN 10: 9780199637225
ISBN 13: 0199637229
Language: EN, FR, DE, ES & NL

Monoclonal Antibodies Book Review:

Monoclonal Antibodies: A Practical Approach covers the preparation, testing, derivation, and applications of monoclonal antibodies. New immunological techniques incorporating tried and tested methodologies are described, making the book of interest to established and inexperienced immunologists. Both the standard somatic hybridization technique and recombinant techniques, including the use of phage libraries, for the preparation of rodent and human monoclonal antibodies are described. Protocols for both the small and large scale production are detailed, as well as purification and labelling (with both radioisotopes and non-radioisotopes) methods. The applications of monoclonal antibodies in immunoblotting, enzyme linked immunoassays, immunofluorescence, and FACS analysis are all covered in detail. Finally protocols are given for the use of monoclonal antibodies in rheumatoid arthritis, tissue typing, detecting DNA modified during chemotherapy, and in the clinical analysis of transplantation samples for malignancy. This book will therefore be an invaluable laboratory companion to anyone using monoclonal antibodies in their research.

Human Monoclonal Antibodies

Human Monoclonal Antibodies
Author: Michael Steinitz
Publsiher: Humana Press
Total Pages: 364
Release: 2013-09-30
ISBN 10: 9781627035859
ISBN 13: 1627035850
Language: EN, FR, DE, ES & NL

Human Monoclonal Antibodies Book Review:

The introduction of monoclonal antibodies revolutionized immunology. The development of human monoclonal antibodies was inspired primarily by the enormous clinical benefits promised by these reagents which can be used as anti-inflammatory reagents, anti-tumor reagents and reagents for passive immunization in a variety of pathologies. Human Monoclonal Antibodies: Methods and Protocols presents technical protocols of cellular and molecular methods for the production, purification and application of human monoclonal antibodies, as well as review articles on related topics of human monoclonal and polyclonal antibodies. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Human Monoclonal Antibodies: Methods and Protocols seeks to serve both professionals and novices with its well-honed methodologies which will prove invaluable in a clinical setting.

Fermentation Processes

Fermentation Processes
Author: Angela Jozala
Publsiher: BoD – Books on Demand
Total Pages: 312
Release: 2017-02-08
ISBN 10: 9535129279
ISBN 13: 9789535129271
Language: EN, FR, DE, ES & NL

Fermentation Processes Book Review:

Fermentation is a theme widely useful for food, feed and biofuel production. Indeed each of these areas, food industry, animal nutrition and energy production, has considerable presence in the global market. Fermentation process also has relevant applications on medical and pharmaceutical areas, such as antibiotics production. The present book, Fermentation Processes, reflects that wide value of fermentation in related areas. It holds a total of 14 chapters over diverse areas of fermentation research.

Monoclonal Hybridoma Antibodies

Monoclonal Hybridoma Antibodies
Author: John G.R. Hurrell
Publsiher: CRC Press
Total Pages: 239
Release: 2018-05-04
ISBN 10: 1351091727
ISBN 13: 9781351091725
Language: EN, FR, DE, ES & NL

Monoclonal Hybridoma Antibodies Book Review:

The first section of this volume is aimed to provide a comprehensive review of the many varied and often empirically derived techniques and procedures currently in use to produce monoclonal hybridoma cell lines and to characterize the antibodies secreted. The goal has been achieved with the chapter contributed by Zola and Brookes who, as each step in the process of hybridoma production and antibody characterisation is reviewed, have provided an experimental procedure found to be satisfactory in their laboratory.The second section of this volume is designed to provide a review of areas in which monoclonal hybridoma antibodies have been of particular advantage. This is a rapidly advancing field which could not be thoroughly reviewed in a single volume.

Trends in Monoclonal Antibody Research

Trends in Monoclonal Antibody Research
Author: Marie A. Simmons
Publsiher: Nova Publishers
Total Pages: 148
Release: 2005
ISBN 10: 9781594545504
ISBN 13: 1594545502
Language: EN, FR, DE, ES & NL

Trends in Monoclonal Antibody Research Book Review:

This new and important international source of information brings together leading-edge research dedicated to monoclonal antibodies. Monoclonal antibodies (MABs) are: antibodies of exceptional purity and specificity; components of the immune system; able to recognise and bind to a specific antigen. Monoclonal antibodies are currently utilised in many diagnostic procedures, including: measuring protein and drug levels in serum; typing tissue and blood; identifying infectious agents; identifying clusters of differentiation for the classification and follow-up therapy of leukaemias and lymphomas; identifying tumour antigens and auto-antibodies; identifying the specific cells involved in the immune response; identifying and quantifying hormones. For example, monoclonal antibodies (MABs or MOABs) work on cancer cells in the same way natural antibodies work, by identifying and binding to the target cells. They then alert other cells in the immune system to the presence of the cancer cells. MABs are specific for a particular antigen-one designed for a B-cell lymphoma will not work on cells for ovarian cancer cells for example.

Production and Characterization of Monoclonal Antibodies Against Recombinant Fatty Acid Binding Protein of Fasciola Gigantica

Production and Characterization of Monoclonal Antibodies Against Recombinant Fatty Acid Binding Protein of Fasciola Gigantica
Author: Anuchittada Sirisriro,Mahāwitthayālai Mahidon,Mahāwitthayālai Mahidon. Khana Witthayāsāt
Publsiher: Unknown
Total Pages: 208
Release: 2001
ISBN 10: 9789746659697
ISBN 13: 9746659693
Language: EN, FR, DE, ES & NL

Production and Characterization of Monoclonal Antibodies Against Recombinant Fatty Acid Binding Protein of Fasciola Gigantica Book Review:

Biomedical Index to PHS supported Research

Biomedical Index to PHS supported Research
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 1994
ISBN 10:
ISBN 13: MINN:31951P003778522
Language: EN, FR, DE, ES & NL

Biomedical Index to PHS supported Research Book Review:

Monoclonal Antibodies

Monoclonal Antibodies
Author: Christian Klein
Publsiher: MDPI
Total Pages: 238
Release: 2018-04-27
ISBN 10: 3038428752
ISBN 13: 9783038428756
Language: EN, FR, DE, ES & NL

Monoclonal Antibodies Book Review:

This book is a printed edition of the Special Issue "Monoclonal Antibodies" that was published in Antibodies

Monoclonal Antibodies

Monoclonal Antibodies
Author: Maher Albitar
Publsiher: Springer Science & Business Media
Total Pages: 228
Release: 2007
ISBN 10: 1597453234
ISBN 13: 9781597453233
Language: EN, FR, DE, ES & NL

Monoclonal Antibodies Book Review:

Monoclonal Antibodies: Methods and Protocols examines a collection of state-of-the-art methods that employ monoclonal antibodies in a clinical setting with opening chapters focusing on the gold standard method for generating mouse monoclonal antibodies through hybridoma technology, future methods for engineering recombinant and humanized antibodies, methods for engineering soluble Fc fusion protein, and the use of antibodies and flow cytometry in the quantification of cell signaling proteins. Specific chapters describe how antibodies are used for the diagnosis and classification of hematologic diseases. Subsequent chapters examine the advantages and most recent advances of using bead-based immunoassays, including the ability of bead-based technology to multiplex and analyze several analytes simultaneously, and the use of beads in detecting fusion proteins resulting from chromosomal translocations. Concluding chapters provide additional examples of methodologies that employ monoclonal antibodies.

Research Awards Index

Research Awards Index
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 1984
ISBN 10:
ISBN 13: IND:30000090650627
Language: EN, FR, DE, ES & NL

Research Awards Index Book Review:

Rat Hybridomas and Rat Monoclonal Antibodies 1990

Rat Hybridomas and Rat Monoclonal Antibodies  1990
Author: Herve Bazin
Publsiher: CRC Press
Total Pages: 534
Release: 2017-11-22
ISBN 10: 1351358286
ISBN 13: 9781351358286
Language: EN, FR, DE, ES & NL

Rat Hybridomas and Rat Monoclonal Antibodies 1990 Book Review:

The purpose of this book is to provide information which supports the fact that rat hybridomas are no more difficult to develop than mouse hybridomas. This is the first book devoted to the development of rat hybridomas. It includes theories, step-by-step techniques, ingredients and apparatus. The focus of this work is on the antibody repertoire, the unique biological properties of rat immunoglobulins, the one-step purification procedure by immunoaffinity chromatography, the absence of C-type particles, and the easy production of large amounts of ascitic fluid containing rat MAb. This rare publication is an absolute must for all scientists using MAbs and those interested in the fields of immunology, biotechnology, and biochemistry.