Molecular Evolutionary Models in Drug Discovery

Molecular Evolutionary Models in Drug Discovery
Author: Juan Bueno
Publsiher: Academic Press
Total Pages: 192
Release: 2020-01-22
ISBN 10: 0128189290
ISBN 13: 9780128189290
Language: EN, FR, DE, ES & NL

Molecular Evolutionary Models in Drug Discovery Book Review:

Molecular Evolutionary Models in Drug Discovery explores the application of evolutionary molecular models in drug discovery in which secondary metabolites play a fundamental role. Secondary metabolites are not produced in isolation, they are the result of the interaction of genes, metabolism and the environment. The book examines the role of secondary metabolites as leads in drug discovery and on the development of a rational bioprospecting model for new medicines based on the evolution of secondary metabolism. These evolutionary models are part of biological systems and are the most reliable expression of the functioning of living beings. Examines the integration and application of evolutionary models in the pharmaceutical industry to create new drug development platforms Investigates the biotechnological prospecting of secondary metabolites and their potential use in the discovery of new drugs Evaluates the ecosystem of living beings and how its molecular adaptation might improve the success of therapies

Molecular Genetic Medicine

Molecular Genetic Medicine
Author: Theodore Friedmann
Publsiher: Elsevier
Total Pages: 254
Release: 2013-10-22
ISBN 10: 1483262057
ISBN 13: 9781483262055
Language: EN, FR, DE, ES & NL

Molecular Genetic Medicine Book Review:

Molecular Genetic Medicine, Volume I, provides an overview of the progress in several of the most important areas of modern molecular genetics and medicine. The aim is to present a technical and historical picture of the concept that it is through a thorough understanding of genetics of all kinds of human diseases, even infectious diseases, that effective treatments will finally come. The book opens with a discussion of the origins and development of the Human Genome Project. This is followed by separate chapters on the development of immune-deficient mice as models for human hematopoietic disease; the application of genetic techniques for testing identity and relatedness of persons; and advances in recombinant DNA technology and their applications in drug discovery. The final chapter discusses the impact of molecular biology and molecular evolution on debates about the origin of humans, and about the origins both of the characteristics that they share with other animals and of those that make humans unique.

Adaptive Systems in Drug Design

Adaptive Systems in Drug Design
Author: Gisbert Schneider,Sung-Sau So
Publsiher: Eurekah.Com Incorporated
Total Pages: 173
Release: 2003
ISBN 10:
ISBN 13: UOM:39015056211819
Language: EN, FR, DE, ES & NL

Adaptive Systems in Drug Design Book Review:

Major concepts in the field of drug design are described in this book, with a strong focus on complex adaptive systems. Special emphasis is placed on neural network applications and evolutionary algorithms. The book is meant to complement a text on computational chemistry and bioinformatices and to present some new challenging ideas. A conceptual framework is presented for the use of adaptive systems and evolutionary algorithms, then the concept of chemical space is discussed and numerous examples of algorithms for classical unsupervised projection methods are given. The use of evolutionary algorithms and artificial neural networks in quantitative structure- activity relationships is discussed, and the drug-likeness concepts is explained. A final chapter examines the utility of evolutionary method in de novo molecular design. Schneider teaches cheminformatics at Johann Wolfgang Goethe University in Germany. So is affiliated with F. Hoffman-La Roche, Inc. Annotation copyrighted by Book News, Inc., Portland, OR

Molecular Modelling and Drug Design

Molecular Modelling and Drug Design
Author: K Anand Solomon
Publsiher: MJP Publisher
Total Pages: 242
Release: 2019-06-05
ISBN 10:
ISBN 13:
Language: EN, FR, DE, ES & NL

Molecular Modelling and Drug Design Book Review:

Molecular modelling is the scientific art of simulating chemicalor biological systems, so that computational methods can beapplied to understand the process concerned. Models usingcomputers are generated using mathematical equations and areevolved based on experimental information that is taken intoconsideration during model building. This book is anintroduction to the field of molecular modelling and drug designin which biological molecules effective in treating diseases arediscovered using in silico methods.

Molecular Evolution

Molecular Evolution
Author: Roderick D.M. Page,Edward C. Holmes
Publsiher: John Wiley & Sons
Total Pages: 352
Release: 2009-07-14
ISBN 10: 1444313363
ISBN 13: 9781444313369
Language: EN, FR, DE, ES & NL

Molecular Evolution Book Review:

The study of evolution at the molecular level has given the subject of evolutionary biology a new significance. Phylogenetic 'trees' of gene sequences are a powerful tool for recovering evolutionary relationships among species, and can be used to answer a broad range of evolutionary and ecological questions. They are also beginning to permeate the medical sciences. In this book, the authors approach the study of molecular evolution with the phylogenetic tree as a central metaphor. This will equip students and professionals with the ability to see both the evolutionary relevance of molecular data, and the significance evolutionary theory has for molecular studies. The book is accessible yet sufficiently detailed and explicit so that the student can learn the mechanics of the procedures discussed. The book is intended for senior undergraduate and graduate students taking courses in molecular evolution/phylogenetic reconstruction. It will also be a useful supplement for students taking wider courses in evolution, as well as a valuable resource for professionals. First student textbook of phylogenetic reconstruction which uses the tree as a central metaphor of evolution. Chapter summaries and annotated suggestions for further reading. Worked examples facilitate understanding of some of the more complex issues. Emphasis on clarity and accessibility.

Directory of Graduate Research

Directory of Graduate Research
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 2001
ISBN 10:
ISBN 13: UCSD:31822032480691
Language: EN, FR, DE, ES & NL

Directory of Graduate Research Book Review:

Faculties, publications and doctoral theses in departments or divisions of chemistry, chemical engineering, biochemistry and pharmaceutical and/or medicinal chemistry at universities in the United States and Canada.

Computational Molecular Evolution

Computational Molecular Evolution
Author: Ziheng Yang
Publsiher: Oxford University Press
Total Pages: 357
Release: 2006-10-05
ISBN 10: 0198566999
ISBN 13: 9780198566991
Language: EN, FR, DE, ES & NL

Computational Molecular Evolution Book Review:

This book describes the models, methods and algorithms that are most useful for analysing the ever-increasing supply of molecular sequence data, with a view to furthering our understanding of the evolution of genes and genomes.

Genetic Algorithms in Molecular Modeling

Genetic Algorithms in Molecular Modeling
Author: James Devillers
Publsiher: Academic Press
Total Pages: 327
Release: 1996-06-07
ISBN 10: 0080532381
ISBN 13: 9780080532387
Language: EN, FR, DE, ES & NL

Genetic Algorithms in Molecular Modeling Book Review:

Genetic Algorithms in Molecular Modeling is the first book available on the use of genetic algorithms in molecular design. This volume marks the beginning of an ew series of books, Principles in Qsar and Drug Design, which will be an indispensible reference for students and professionals involved in medicinal chemistry, pharmacology, (eco)toxicology, and agrochemistry. Each comprehensive chapter is written by a distinguished researcher in the field. Through its up to the minute content, extensive bibliography, and essential information on software availability, this book leads the reader from the theoretical aspects to the practical applications. It enables the uninitiated reader to apply genetic algorithms for modeling the biological activities and properties of chemicals, and provides the trained scientist with the most up to date information on the topic. . Extremely topical and timely . Sets the foundations for the development of computer-aided tools for solving numerous problems in QSAR and drug design . Written to be accessible without prior direct experience in genetic algorithms

S T Today

S T Today
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 2005
ISBN 10:
ISBN 13: IND:30000107503264
Language: EN, FR, DE, ES & NL

S T Today Book Review:

Abstracts 18th Annual Meetings April 3 April 24 1989

Abstracts  18th Annual Meetings  April 3 April 24  1989
Author: Anonim
Publsiher: Unknown
Total Pages: 328
Release: 1989
ISBN 10:
ISBN 13: CORNELL:31924052383688
Language: EN, FR, DE, ES & NL

Abstracts 18th Annual Meetings April 3 April 24 1989 Book Review:

EMBASE List of Journals Indexed

EMBASE List of Journals Indexed
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 2005
ISBN 10:
ISBN 13: UCLA:L0091078741
Language: EN, FR, DE, ES & NL

EMBASE List of Journals Indexed Book Review:

Evolutionary Algorithms in Molecular Design

Evolutionary Algorithms in Molecular Design
Author: David E. Clark
Publsiher: John Wiley & Sons
Total Pages: 288
Release: 2008-11-21
ISBN 10: 352761317X
ISBN 13: 9783527613175
Language: EN, FR, DE, ES & NL

Evolutionary Algorithms in Molecular Design Book Review:

When trying to find new methods and problem-solving strategies for their research, scientists often turn to nature for inspiration. An excellent example of this is the application of Darwin's Theory of Evolution, particularly the notion of the 'survival of the fittest', in computer programs designed to search for optimal solutions to many kinds of problems. These 'evolutionary algorithms' start from a population of possible solutions to a given problem and, by applying evolutionary principles, evolve successive generations with improved characteristics until an optimal, or near-optimal, solution is obtained. This book highlights the versatility of evolutionary algorithms in areas of relevance to molecular design with a particular focus on drug design. The authors, all of whom are experts in their field, discuss the application of these computational methods to a wide range of research problems including conformational analysis, chemometrics and quantitative structure-activity relationships, de novo molecular design, chemical structure handling, combinatorial library design, and the study of protein folding. In addition, the use of evolutionary algorithms in the determination of structures by X-ray crystallography and NMR spectroscopy is also covered. These state-of-the-art reviews, together with a discussion of new techniques and future developments in the field, make this book a truly valuable and highly up-to-date resource for anyone engaged in the application or development of computer-assisted methods in scientific research.

Abstracts of Papers Presented at the 1999 Meeting on Genome Sequencing Biology

Abstracts of Papers Presented at the 1999 Meeting on Genome Sequencing   Biology
Author: Anonim
Publsiher: Unknown
Total Pages: 269
Release: 1999
ISBN 10:
ISBN 13: UCLA:L0079483103
Language: EN, FR, DE, ES & NL

Abstracts of Papers Presented at the 1999 Meeting on Genome Sequencing Biology Book Review:

Model Organisms in Drug Discovery

Model Organisms in Drug Discovery
Author: Pamela M. Carroll,Kevin Fitzgerald
Publsiher: John Wiley & Sons
Total Pages: 288
Release: 2003-11-21
ISBN 10:
ISBN 13: UOM:39015057633144
Language: EN, FR, DE, ES & NL

Model Organisms in Drug Discovery Book Review:

Fruit flies are "little people with wings" goes the saying in the scientific community, ever since the completion of the Human Genome Project and its revelations about the similarity amongst the genomes of different organisms. It is humbling that most signalling pathways which "define" humans are conserved in Drosophila, the common fruit fly. Feed a fruit fly caffeine and it has trouble falling asleep; feed it antihistamines and it cannot stay awake. A C. elegans worm placed on the antidepressant flouxetine has increased serotonin levels in its tiny brain. Yeast treated with chemotherapeutics stop their cell division. Removal of a single gene from a mouse or zebrafish can cause the animals to develop Alzheimer’s disease or heart disease. These organisms are utilized as surrogates to investigate the function and design of complex human biological systems. Advances in bioinformatics, proteomics, automation technologies and their application to model organism systems now occur on an industrial scale. The integration of model systems into the drug discovery process, the speed of the tools, and the in vivo validation data that these models can provide, will clearly help definition of disease biology and high-quality target validation. Enhanced target selection will lead to the more efficacious and less toxic therapeutic compounds of the future. Leading experts in the field provide detailed accounts of model organism research that have impacted on specific therapeutic areas and they examine state-of-the-art applications of model systems, describing real life applications and their possible impact in the future. This book will be of interest to geneticists, bioinformaticians, pharmacologists, molecular biologists and people working in the pharmaceutical industry, particularly genomics.

Comprehensive medicinal chemistry II

Comprehensive medicinal chemistry II
Author: John B. Taylor,D. J. Triggle
Publsiher: Elsevier Science Ltd
Total Pages: 7200
Release: 2007
ISBN 10: 9780080445137
ISBN 13: 0080445136
Language: EN, FR, DE, ES & NL

Comprehensive medicinal chemistry II Book Review:

The first edition of Comprehensive Medicinal Chemistry was published in 1990 and very well received. Comprehensive Medicinal Chemistry II is much more than a simple updating of the contents of the first edition. Completely revised and expanded, this new edition has been refocused to reflect the significant developments and changes over the past decade in genomics, proteomics, bioinformatics, combinatorial chemistry, high-throughput screening and pharmacology, and more. The content comprises the most up-to-date, authoritative and comprehensive reference text on contemporary medicinal chemistry and drug research, covering major therapeutic classes and targets, research strategy and organisation, high-throughput technologies, computer-assisted design, ADME and selected case histories. It is this coverage of the strategy, technologies, principles and applications of medicinal chemistry in a single work that will make Comprehensive Medicinal Chemistry II a unique work of reference and a single point of entry to the literature for pharmaceutical and biotechnology scientists of all disciplines and for many industry executives as well.Comprehensive Medicinal Chemistry II will be available online in 2007 via the proven platform ScienceDirect providing the user with enhanced features such as cross-referencing and dynamic linking. * Comprehensively reviews - for the first time in one single work - the strategies, technologies, principles and applications of modern medicinal chemistry * Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets * Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs

Burger s Medicinal Chemistry and Drug Discovery Drug Discovery

Burger s Medicinal Chemistry and Drug Discovery  Drug Discovery
Author: Donald J. Abraham
Publsiher: Wiley-Interscience
Total Pages: 968
Release: 2003
ISBN 10: 9780471270904
ISBN 13: 0471270903
Language: EN, FR, DE, ES & NL

Burger s Medicinal Chemistry and Drug Discovery Drug Discovery Book Review:

This is Volume 1: Drug Discovery, of Burger's Medicinal Chemistry and Drug Discovery, 6th Edition. This new volume contains critical new chapters on Virtual Screening, Bioinformatics and Chemical Information Computing Systems in Drug Discovery. To purchase the entire 6 volume set, please refer to ISBN 0-471-37032-0. For a complete list of articles and contributors as well as FREE sample chapters from this new 6th Edition please visit: www.mrw.interscience.wiley.com/bmcdd

Science

Science
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 2002
ISBN 10:
ISBN 13: UCSB:31205025584648
Language: EN, FR, DE, ES & NL

Science Book Review:

Preclinical Evaluation of Antimicrobial Nanodrugs

Preclinical Evaluation of Antimicrobial Nanodrugs
Author: Juan Bueno
Publsiher: Springer Nature
Total Pages: 117
Release: 2020-05-08
ISBN 10: 3030438554
ISBN 13: 9783030438555
Language: EN, FR, DE, ES & NL

Preclinical Evaluation of Antimicrobial Nanodrugs Book Review:

Translational medicine addresses the gap between research and the clinical application of new discoveries. To efficiently deliver new drugs to care centers, a preclinical evaluation, both in vitro and in vivo, is required to ensure that the most active and least toxic compounds are selected as well as to predict clinical outcome. Antimicrobial nanomedicines have been shown to have higher specificity in their therapeutic targets and the ability to serve as adjuvants, increasing the effectiveness of pre-existing immune compounds. The design and development of new standardized protocols for evaluating antimicrobial nanomedicines is needed for both the industry and clinical laboratory. These protocols must aim to evaluate laboratory activity and present models of pharmacokinetic-pharmacodynamic and toxicokinetic behavior that predict absorption and distribution. Likewise, these protocols must follow a theranostics approach, be able to detect promising formulations, diagnose the infectious disease, and determine the correct treatment to implement a personalized therapeutic behavior. Given the possibilities that nanotechnology offers, not updating to new screening platforms is inadequate as it prevents the correct application of discoveries, increasing the effect of the valley of death between innovations and their use. This book is structured to discuss the fundamentals taken into account for the design of robust, reproducible and automatable evaluation platforms. These vital platforms should enable the discovery of new medicines with which to face antimicrobial resistance (RAM), one of the great problems of our time.

International Journal of Oriental Medicine

International Journal of Oriental Medicine
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 1998
ISBN 10:
ISBN 13: UCLA:L0078757911
Language: EN, FR, DE, ES & NL

International Journal of Oriental Medicine Book Review:

Parasites Molecular Biology Drug and Vaccine Design

Parasites  Molecular Biology  Drug and Vaccine Design
Author: Nina Agabian,Anthony Cerami
Publsiher: Unknown
Total Pages: 504
Release: 1990
ISBN 10:
ISBN 13: UOM:39015017994354
Language: EN, FR, DE, ES & NL

Parasites Molecular Biology Drug and Vaccine Design Book Review:

This wide-ranging collection of edited papers examines the many mechanisms that allow parasites to survive and interact in a host environment. The research explains how a more knowledgeable understanding of host-parasite interactions aids in the development of unique strategies for vaccine design and applied research in clinical diagnostics and therapeutics. Divided into five parts, the text covers gene expression during parasite differentiation and development; the potential for molecular genetics in parasite systems; molecules of the parasite membrane; molecular modeling and parasite drug design; and vaccines.