Molecular Diagnostics and Treatment of Pancreatic Cancer

Molecular Diagnostics and Treatment of Pancreatic Cancer
Author: Asfar Azmi
Publsiher: Elsevier
Total Pages: 458
Release: 2014-04-14
ISBN 10: 0124079466
ISBN 13: 9780124079465
Language: EN, FR, DE, ES & NL

Molecular Diagnostics and Treatment of Pancreatic Cancer Book Review:

Molecular Diagnostics and Treatment of Pancreatic Cancer describes the different emerging applications of systems biology and how it is shaping modern pancreatic cancer research. This book begins by introducing the current state of the art knowledge, trends in diagnostics, progress in disease model systems as well as new treatment and palliative care strategies in pancreatic cancer. Specific sections are dedicated to enlighten the readers to newer discoveries that have emerged from gene expression profiling, proteomics, metabolomics and systems level analyses of pancreatic cancer datasets. First of a kind and novel network strategies to understand oncogenic Kras signaling in pancreatic tumors are presented. The attempts to computationally model and prioritize microRNAs that cause pancreatic cancer resistance are also highlighted. Addressing this important area, Molecular Diagnostics and Treatment of Pancreatic Cancer provides insights into important network evaluation methodologies related to pancreatic cancer related microRNAs targetome. There are dedicated chapters on critical aspects of the evolving yet controversial field of pancreatic cancer stems cells. The work concludes by discussing the applications of network sciences in pancreatic cancer drug discovery and clinical trial design. Encompasses discussion of innovative tools including expression signatures in cell lines, 3D models, animal xenograft models, primary models and patient derived samples, aiding subversion of traditional biology paradigms, and enhancing comprehension across conventional length and temporal scales Coverage includes novel applications in targeted drugs, polypharmacology, network pharmacology and other related drug development arenas – helping researchers in pancreatic cancer drug discovery Summarizes many relevant computational and clinical references from fast-evolving literature Comprehensive glossary helps newer readers understand technical terms and specialized nomenclature

Molecular Diagnostics in Cancer Patients

Molecular Diagnostics in Cancer Patients
Author: Kamla Kant Shukla,Praveen Sharma,Sanjeev Misra
Publsiher: Springer
Total Pages: 341
Release: 2019-03-15
ISBN 10: 981135877X
ISBN 13: 9789811358777
Language: EN, FR, DE, ES & NL

Molecular Diagnostics in Cancer Patients Book Review:

This book aims to bring together a broad variety of examples of the role of pharmacogenomics in current drug development, uncovering dynamic concentration-dependent drug responses on biological systems to understand pharmacodynamics responses in human cancer where genetic lesions serve as tumor markers and provide a basis for cancer diagnosis. The book describes methods and protocols applied in molecular diagnostics. It offers pathologists and researchers providing molecular diagnostic services an array of the most recent and readily accessible reference to compare methods and techniques. Highlights include the molecular diagnosis of genetic aberrations by quantitative polymerase reaction (qPCR), sequence-specific oligonucleotide arrays, next-generation sequencing (NGS), CGH arrays-and methodologies directed at the detection of epigenetic events, high-throughput nucleic acid and protein arrays, direct sequencing and FISH-based methodologies, currently used in the diagnosis of solid tumors. The book also includes an innovative line of treatment in relation to the molecular prognosis, diagnosis and pharmacogenomics in the actual practice of clinical findings at molecular levels. The book covers the applications of numerous genetic testing methodologies; in approximately the chronological order of discovery and high-throughput diagnosis using advanced genomic approaches to identify such genes, in the search for novel drug targets and/or key determinants of drug reactions. It also promotes a wider understanding of molecular diagnostics among physicians, medical students, and scientists in academics, industry and corporate world.

Pancreatic Cancer

Pancreatic Cancer
Author: Howard Reber
Publsiher: Springer Science & Business Media
Total Pages: 347
Release: 1998-05-26
ISBN 10:
ISBN 13: UOM:39015045619387
Language: EN, FR, DE, ES & NL

Pancreatic Cancer Book Review:

A distinguished panel of world authorities reviews the current state of today's understanding, diagnosis, and treatment of pancreatic cancer. Their cutting-edge reviews discuss both medical and surgical modalities and include numerous insights into the basic molecular processes underlying the disease. Among the key topics covered are the prospects for early diagnosis using molecular techniques, the latest diagnostic and therapeutic methods, the role of laparoscopy (diagnostic and therapeutic), and nonsurgical treatment. The reviewers also address the future possibilities for clinical advances, quality of life concerns, and the value of the Japanese "extended Whipple resection." Pancreatic Cancer will become the new standard reference for all clinicians who diagnose and treat this disease, as well as for basic scientists needing a summary of the many recent advances. i

Molecular Pathology and Diagnostics of Cancer

Molecular Pathology and Diagnostics of Cancer
Author: Domenico Coppola
Publsiher: Springer Science & Business Media
Total Pages: 601
Release: 2013-11-29
ISBN 10: 9400771924
ISBN 13: 9789400771925
Language: EN, FR, DE, ES & NL

Molecular Pathology and Diagnostics of Cancer Book Review:

Molecular pathology is based on the emergence of new techniques that greatly enhance the diagnostic accuracy when facing with challenging differential diagnoses. In addition, new molecular techniques are entering the clinical arena for their value in predicting therapy response and tumor prognosis. This book provides a guide for the practicing pathologist and for both pathology residents and fellows during the daily sign-out of challenging cases. The book is organized by anatomical systems and provides a detailed description of molecular tests that may help in the diagnosis. Furthermore, a description of the current molecular tests required to identify patients for treatment is offered. The application of molecular pathology techniques to the clinical practice has already shown its usefulness and the number of such tests is growing exponentially as more molecular targets are discovered. Molecular Pathology and Diagnostics of Cancer will give practicing and training pathologists an up-to date resource to guide the correct management of pathology cases requiring molecular testing.

Theranostic Approach for Pancreatic Cancer

Theranostic Approach for Pancreatic Cancer
Author: Ganji Purnachandra Nagaraju,Sarfraz Ahmad
Publsiher: Academic Press
Total Pages: 410
Release: 2019-08-19
ISBN 10: 0128194588
ISBN 13: 9780128194584
Language: EN, FR, DE, ES & NL

Theranostic Approach for Pancreatic Cancer Book Review:

Theranostic Approach for Pancreatic Cancer modulates the biologic properties of stroma in pancreatic cancer by targeting the several chemotherapy resistance mechanisms to impede their malignant property through introducing new strategies and drugs for tackling the disease. It brings information about ongoing research as well as clinical data about pancreatic cancer and provides detailed descriptions about diagnostic and therapeutic options for easy understanding. The book discusses several topics related to pancreatic cancer, such as stem cells, drug resistance and pancreatic tumor microenvironment, the latest developments in chemotherapy for metastatic cancer and chemoprevention, and epigenome as a therapeutic strategy. Additionally, it encompasses a discussion on theranostic clinical applications for personalized treatment and management of pancreatic cancer. The book is a valuable resource for cancer researchers, oncologists, and several members of the biomedical field who need to understand more about the diagnosis and treatment of pancreatic cancer. Provides information on the roadblocks of chemotherapy in patients with newly diagnosed and metastatic pancreatic cancer“/li> Discusses treatment options available currently and prospective options for the future Focuses especially on stroma, tumor microenvironment, stem cells, stellate cells, transcription factors, growth factors, and important signaling pathways as already tested types of treatment

Diagnostic Molecular Pathology

Diagnostic Molecular Pathology
Author: William B. Coleman,Gregory J. Tsongalis
Publsiher: Academic Press
Total Pages: 582
Release: 2016-10-05
ISBN 10: 0128011572
ISBN 13: 9780128011577
Language: EN, FR, DE, ES & NL

Diagnostic Molecular Pathology Book Review:

Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing is organized around disease types (genetic disease, infectious disease, neoplastic disease, among others). In each section, the authors provide background on disease mechanisms and describe how laboratory testing is built on knowledge of these mechanisms. Sections are dedicated to general methodologies employed in testing (to convey the concepts reflected in the methods), and specific description of how these methods can be applied and are applied to specific diseases are described. The book does not present molecular methods in isolation, but considers how other evidence (symptoms, radiology or other imaging, or other clinical tests) is used to guide the selection of molecular tests or how these other data are used in conjunction with molecular tests to make diagnoses (or otherwise contribute to clinical workup). In addition, final chapters look to the future (new technologies, new approaches) of applied molecular pathology and how discovery-based research will yield new and useful biomarkers and tests. Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing contains exercises to test readers on their understanding of how molecular diagnostic tests are utilized and the value of the information that can be obtained in the context of the patient workup. Readers are directed to an ancillary website that contains supplementary materials in the form of exercises where decision trees can be employed to simulate actual clinical decisions. Focuses on the menu of molecular diagnostic tests available in modern molecular pathology or clinical laboratories that can be applied to disease detection, diagnosis, and classification in the clinical workup of a patient Explains how molecular tests are utilized to guide the treatment of patients in personalized medicine (guided therapies) and for prognostication of disease Features an ancillary website with self-testing exercises where decision trees can be employed to simulate actual clinical decisions Highlights new technologies and approaches of applied molecular pathology and how discovery-based research will yield new and useful biomarkers and tests

Cumulated Index Medicus

Cumulated Index Medicus
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 1997
ISBN 10:
ISBN 13: UIUC:30112001088456
Language: EN, FR, DE, ES & NL

Cumulated Index Medicus Book Review:

The National Institutes of Health

The National Institutes of Health
Author: United States. Congress. House. Committee on Energy and Commerce. Subcommittee on Health
Publsiher: Unknown
Total Pages: 114
Release: 2013
ISBN 10:
ISBN 13: MINN:31951D03647348Y
Language: EN, FR, DE, ES & NL

The National Institutes of Health Book Review:

Pancreatic Cancer

Pancreatic Cancer
Author: Daniel D. Von Hoff,Douglas Brian Evans,Ralph H. Hruban
Publsiher: Jones & Bartlett Learning
Total Pages: 832
Release: 2005
ISBN 10: 9780763721787
ISBN 13: 0763721786
Language: EN, FR, DE, ES & NL

Pancreatic Cancer Book Review:

Pancreatic cancer is the fourth leading cause of cancer death in the United States and has the worst mortality rate of any cancer. It is very likely that the number of deaths from pancreatic cancer each year will surpass the number of deaths from other more common cancers, such as breast cancer. This volume is dedicated to helping curb these daunting statistics by providing a knowledge base for clinicians and scientists who want to make a difference for patients both now and in the future. Edited by an eminent team consisting of a medical oncologist, a cancer surgeon and a pathologist, with contributions from over 100 world-class experts in the field, the book includes 54 state of the art chapters -- all with full color illustrations. Special "Commentaries," written by world authorities on the subject, provide expert analysis and counterpoint to selected topics.

Departments of Labor and Health and Human Services Education and Related Agencies Appropriations

Departments of Labor  and Health and Human Services  Education  and Related Agencies Appropriations
Author: United States. Congress. Senate. Committee on Appropriations
Publsiher: Unknown
Total Pages: 329
Release: 2003
ISBN 10:
ISBN 13: PSU:000050198580
Language: EN, FR, DE, ES & NL

Departments of Labor and Health and Human Services Education and Related Agencies Appropriations Book Review:

Research Awards Index

Research Awards Index
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 1987
ISBN 10:
ISBN 13: UOM:39015012725779
Language: EN, FR, DE, ES & NL

Research Awards Index Book Review:

Molecular Diagnostics

Molecular Diagnostics
Author: Wayne W. Grody,Robert M. Nakamura,Frederick L. Kiechle,Charles Strom
Publsiher: Academic Press
Total Pages: 736
Release: 2009-11-06
ISBN 10: 9780080919041
ISBN 13: 0080919049
Language: EN, FR, DE, ES & NL

Molecular Diagnostics Book Review:

Advances in genomic and proteomic profiling of disease have transformed the field of molecular diagnostics, thus leading the way for a major revolution in clinical practice. While the range of tests for disease detection and staging is rapidly expanding, many physicians lack the knowledge required to determine which tests to order and how to interpret results. Molecular Diagnostics provides a complete guide to the use and interpretation of molecular testing in the clinical arena. No other available resource offers this emphasis, comprehensive scope, and practical utility in the clinical setting. Serves as the definitivereference for molecular pathologists worldwide Covers a variety of molecular techniques including next generation sequencing, tumor somatic cell genotyping, infectious and genetic disease tecting, and pharmacogenetics Discusses in the detail issues concerning quality assurance, regulation, ethics, and future directions for the science

Pancreatic Cancer

Pancreatic Cancer
Author: Sanjay Srivastava
Publsiher: BoD – Books on Demand
Total Pages: 326
Release: 2012-03-28
ISBN 10: 9535103946
ISBN 13: 9789535103943
Language: EN, FR, DE, ES & NL

Pancreatic Cancer Book Review:

This book covers pancreatic cancer risk factors, treatment and clinical procedures. It provides an outline of pancreatic cancer genetic risk factors, biomarkers and systems biology for the better understanding of disease. As pancreatic cancer suffers from lack of early diagnosis or prognosis markers, this book encompasses stem cell and genetic makers to identify the disease in early stages. The book uncovers the rationale and effectiveness of monotherapy and combination therapy in combating the devastating disease. As immunotherapy is emerging as an attractive approach to cease pancreatic cancer progression, the present book covers various aspects of immunotherapy including innate, adaptive, active, passive and bacterial approaches. Management of anesthesia during surgery and pain after surgery has been discussed. Book also takes the reader through the role of endoscopy and fine needle guided biopsies in diagnosing and observing the disease progression.

Cystic Tumors of the Pancreas

Cystic Tumors of the Pancreas
Author: Marco Del Chiaro,Stephan L. Haas,Richard D. Schulick
Publsiher: Springer
Total Pages: 181
Release: 2016-07-14
ISBN 10: 3319318829
ISBN 13: 9783319318820
Language: EN, FR, DE, ES & NL

Cystic Tumors of the Pancreas Book Review:

This book provides a detailed, up-to-date overview of cystic tumors of the pancreas, with coverage of all aspects of diagnosis and treatment (medical, endoscopic, and surgical). After opening chapters on pathology and classification, cytology, molecular biology, and epidemiology, the role of each of the relevant diagnostic methods is carefully examined. The treatment-related chapters describe surgical approaches, including minimally invasive surgery, as well as ablation modalities and chemo-radiotherapy. Thorough guidance is also provided specifically on the management of cystic tumors in high-risk cases and on follow-up. The authors are global opinion leaders in their field who have contributed cutting-edge chapters, with emphasis on clear diagnostic and therapeutic algorithms and with numerous supporting tables and illustrations. Owing to the widespread use of imaging modalities, clinicians are being confronted by an increasing number of patients with cystic tumors of the pancreas, ranging from benign cysts to metastasized malignancies. The widening spectrum of available diagnostic measures has resulted in controversy over the choice of further means of investigation when cystic changes are encountered, and the growth in therapeutic options has similarly been accompanied by considerable debate over their use. Against this background, Cystic Tumors of the Pancreas will be a valuable source of relevant information for both clinicians and surgeons and will also be of interest to radiologists, pathologists, and basic scientists.

Advances in Pancreatic Cancer

Advances in Pancreatic Cancer
Author: Luis Rodrigo
Publsiher: BoD – Books on Demand
Total Pages: 224
Release: 2018-09-05
ISBN 10: 1789236401
ISBN 13: 9781789236408
Language: EN, FR, DE, ES & NL

Advances in Pancreatic Cancer Book Review:

Pancreatic cancer is a growing source of cancer-related death and has poor survival rates, which have not improved in the last few decades. Its high-mortality rate is attributed to pancreatic cancer biology, difficulty in early diagnosis, and lack of standardized international guidelines in assessing the pancreatic masses. This book aims to provide an update in the current state of play in pancreatic cancer diagnosis and to evaluate the benefits and limitations of the available diagnostic technology and therapy. The main modalities for diagnosis are imaging with HCT, MRI, USE, and PET. Some chapters review the improvements in the techniques used. Timely and accurate diagnosis of pancreatic cancer can lead to improve in the current poor outcome of this disease.

Pancreatic Cancer Cystic Neoplasms and Endocrine Tumors

Pancreatic Cancer  Cystic Neoplasms and Endocrine Tumors
Author: Hans G. Beger,Akimasa Nakao,John P. Neoptolemos,Shu You Peng,Michael G. Sarr
Publsiher: John Wiley & Sons
Total Pages: 456
Release: 2015-04-27
ISBN 10: 0470673184
ISBN 13: 9780470673188
Language: EN, FR, DE, ES & NL

Pancreatic Cancer Cystic Neoplasms and Endocrine Tumors Book Review:

Pancreatic Cancer, Cystic Neoplasms and Endocrine Tumors: Diagnosis and Management is a modern, expertly crafted and clinically focused guide to the diagnosis, management and best-practice care of patients suffering from pancreatic cancer, cystic neoplasms and endocrine tumours. Packed with outstanding figures and with reference to the leading society guidelines, its main focus is on the many endoscopic and radiologic diagnostic techniques, medical and surgical management of both full-blown cancer and other tumors, and the risks of each form of treatment. Also covered in detail are issues of tumor recurrence and long-term outcome of treatment. Brought to you by highly skilled national and international leaders in the specialty and an experienced editor team, this is an invaluable guide to practicing gastroenterologists and surgeons in the hospital and clinical environment, as well as oncologists and endocrinologists managing patients with pancreatic tumorous lesions.

Principles of Molecular Diagnostics and Personalized Cancer Medicine

Principles of Molecular Diagnostics and Personalized Cancer Medicine
Author: Dongfeng Tan,Henry T. Lynch
Publsiher: Lippincott Williams & Wilkins
Total Pages: 968
Release: 2013-01-01
ISBN 10: 9781451131970
ISBN 13: 1451131976
Language: EN, FR, DE, ES & NL

Principles of Molecular Diagnostics and Personalized Cancer Medicine Book Review:

Principles of Molecular Diagnostics and Personalized Cancer Medicine The role of molecular genetics in the treatment of malignancy continues to grow at an astonishing rate. Today's subspecialized multidisciplinary approach to oncology has incorporated advances in targeted molecular therapy, prognosis, risk assessment, and prevention—all based at least in part on molecular diagnostics and imaging. Inside this cutting-edge resource, readers will explore broad, comprehensive perspectives on the current trends in molecular diagnosis of cancer and personalized cancer medicine. Authoritative discussions share insights from noted experts in cancer research, clinical trials, molecular diagnostics, personalized therapy, bioinformatics, and federal regulations. From the basic mechanisms of carcinogenesis to the most advanced molecular screening, staging, and treatment technologies, readers will discover clear and straightforward discussions directly relevant to patient diagnosis and care. Improve your understanding of… • The basic mechanisms of carcinogenesis—including material on cell proliferation, signal transduction pathways, cancer stem cells, and the interaction between genetics and environmental factors. • The most current molecular techniques—including polymerase chain reaction (PCR) technique, single nucleotide polymorphisms, cancer cytogenomics and epigenetics, whole-genome assessments, and next- generation sequencing. • Molecular tests—including molecular screening, minimal residual disease detection, circulating tumor cell tests, molecular tumor staging, and molecular cancer prognosis assessment. • Imaging and screening technologies—including molecular imaging, genetic tests, biostatistics, and bioinformatics. • The molecular basis of therapy—including critical molecules as special treatment targets, particularly genes/DNA, RNA, micro RNAs, proteins/antibodies, and nanoparticles. • Molecular diagnostics – including updated molecular diagnostic approaches to common malignancies and role of pathology in targeted cancer management. • Targeted treatment – including personalized medicine and targeted therapy for commonly occurring malignancies— plus insights on new approaches to targeted drug discovery and the future of molecular oncology!

Challenges in Pancreatic Pathology

Challenges in Pancreatic Pathology
Author: Andrada Seicean
Publsiher: BoD – Books on Demand
Total Pages: 242
Release: 2017-04-26
ISBN 10: 953513115X
ISBN 13: 9789535131151
Language: EN, FR, DE, ES & NL

Challenges in Pancreatic Pathology Book Review:

The assessment of the pancreas is a challenging problem because it has a profound location and it often presents difficulties in diagnosis and treatment. Despite many efforts in dealing with pancreatic diseases, the pathogenesis is not completely understood, the symptoms and imaging methods are unspecific, and the treatment possibilities are sometimes very limited. The major purpose of this book is to offer the reader a better understanding of the challenging aspects in pancreatic pathology, starting with anatomy and following with different pancreatic pathology. More space is allotted to pancreatic cancer, including surgical procedures, and to the management of the cystic lesions of the pancreas. This book is meant to provide a thorough guide for the best approaches in some of the difficult problems in pancreatology.

Conquering RAS

Conquering RAS
Author: Asfar Azmi
Publsiher: Academic Press
Total Pages: 294
Release: 2016-08-11
ISBN 10: 0128035412
ISBN 13: 9780128035412
Language: EN, FR, DE, ES & NL

Conquering RAS Book Review:

Conquering RAS: From Biology to Cancer Therapy provides introductory knowledge on how modern RAS biology is taking shape in light of newer technological development. Each chapter is written in a manner that emphasizes simplicity and readability for both new investigators and established researchers. While RAS biology has been intensively studied for more than three decades, we are yet to see any effective therapeutics that could interfere in the signaling cascade regulated by this master oncogene. The book covers topics ranging from basic RAS biology, to translational biology and drug discovery applications. These topics will be appealing to basic researchers working in labs who seek deeper understanding of the modern concepts in RAS research. On the other side, the oncologist at the patient’s bedside will find the book useful as they routinely face the daunting task of treating patients that predominantly have a disease driven by oncogenic KRAS. Brings together wide ranging topics in RAS basic and translational biology for the scientific and clinical communities Showcases recent advancements in RAS research under one comprehensive volume Includes video clips, color illustrations, and important website links to facilitate a clear understanding of RAS in cancer research

Molecular Diagnostics

Molecular Diagnostics
Author: George P. Patrinos,Wilhelm Ansorge,Phillip B. Danielson
Publsiher: Academic Press
Total Pages: 520
Release: 2016-10-27
ISBN 10: 0128029889
ISBN 13: 9780128029886
Language: EN, FR, DE, ES & NL

Molecular Diagnostics Book Review:

Molecular Diagnostics, Third Edition, focuses on the technologies and applications that professionals need to work in, develop, and manage a clinical diagnostic laboratory. Each chapter contains an expert introduction to each subject that is next to technical details and many applications for molecular genetic testing that can be found in comprehensive reference lists at the end of each chapter. Contents are divided into three parts, technologies, application of those technologies, and related issues. The first part is dedicated to the battery of the most widely used molecular pathology techniques. New chapters have been added, including the various new technologies involved in next-generation sequencing (mutation detection, gene expression, etc.), mass spectrometry, and protein-specific methodologies. All revised chapters have been completely updated, to include not only technology innovations, but also novel diagnostic applications. As with previous editions, each of the chapters in this section includes a brief description of the technique followed by examples from the area of expertise from the selected contributor. The second part of the book attempts to integrate previously analyzed technologies into the different aspects of molecular diagnostics, such as identification of genetically modified organisms, stem cells, pharmacogenomics, modern forensic science, molecular microbiology, and genetic diagnosis. Part three focuses on various everyday issues in a diagnostic laboratory, from genetic counseling and related ethical and psychological issues, to safety and quality management. Presents a comprehensive account of all new technologies and applications used in clinical diagnostic laboratories Explores a wide range of molecular-based tests that are available to assess DNA variation and changes in gene expression Offers clear translational presentations by the top molecular pathologists, clinical chemists, and molecular geneticists in the field