Molecular Diagnostics and Treatment of Pancreatic Cancer

Molecular Diagnostics and Treatment of Pancreatic Cancer
Author: Asfar Azmi
Publsiher: Elsevier
Total Pages: 458
Release: 2014-04-14
ISBN 10: 0124079466
ISBN 13: 9780124079465
Language: EN, FR, DE, ES & NL

Molecular Diagnostics and Treatment of Pancreatic Cancer Book Review:

Molecular Diagnostics and Treatment of Pancreatic Cancer describes the different emerging applications of systems biology and how it is shaping modern pancreatic cancer research. This book begins by introducing the current state of the art knowledge, trends in diagnostics, progress in disease model systems as well as new treatment and palliative care strategies in pancreatic cancer. Specific sections are dedicated to enlighten the readers to newer discoveries that have emerged from gene expression profiling, proteomics, metabolomics and systems level analyses of pancreatic cancer datasets. First of a kind and novel network strategies to understand oncogenic Kras signaling in pancreatic tumors are presented. The attempts to computationally model and prioritize microRNAs that cause pancreatic cancer resistance are also highlighted. Addressing this important area, Molecular Diagnostics and Treatment of Pancreatic Cancer provides insights into important network evaluation methodologies related to pancreatic cancer related microRNAs targetome. There are dedicated chapters on critical aspects of the evolving yet controversial field of pancreatic cancer stems cells. The work concludes by discussing the applications of network sciences in pancreatic cancer drug discovery and clinical trial design. Encompasses discussion of innovative tools including expression signatures in cell lines, 3D models, animal xenograft models, primary models and patient derived samples, aiding subversion of traditional biology paradigms, and enhancing comprehension across conventional length and temporal scales Coverage includes novel applications in targeted drugs, polypharmacology, network pharmacology and other related drug development arenas – helping researchers in pancreatic cancer drug discovery Summarizes many relevant computational and clinical references from fast-evolving literature Comprehensive glossary helps newer readers understand technical terms and specialized nomenclature

Molecular Diagnostics and Treatment of Pancreatic Cancer

Molecular Diagnostics and Treatment of Pancreatic Cancer
Author: Asfar Azmi
Publsiher: Academic Press
Total Pages: 446
Release: 2014-04-17
ISBN 10: 9780124081031
ISBN 13: 0124081037
Language: EN, FR, DE, ES & NL

Molecular Diagnostics and Treatment of Pancreatic Cancer Book Review:

Molecular Diagnostics and Treatment of Pancreatic Cancer describes the different emerging applications of systems biology and how it is shaping modern pancreatic cancer research. This book begins by introducing the current state of the art knowledge, trends in diagnostics, progress in disease model systems as well as new treatment and palliative care strategies in pancreatic cancer. Specific sections are dedicated to enlighten the readers to newer discoveries that have emerged from gene expression profiling, proteomics, metabolomics and systems level analyses of pancreatic cancer datasets. First of a kind and novel network strategies to understand oncogenic Kras signaling in pancreatic tumors are presented. The attempts to computationally model and prioritize microRNAs that cause pancreatic cancer resistance are also highlighted. Addressing this important area, Molecular Diagnostics and Treatment of Pancreatic Cancer provides insights into important network evaluation methodologies related to pancreatic cancer related microRNAs targetome. There are dedicated chapters on critical aspects of the evolving yet controversial field of pancreatic cancer stems cells. The work concludes by discussing the applications of network sciences in pancreatic cancer drug discovery and clinical trial design. Encompasses discussion of innovative tools including expression signatures in cell lines, 3D models, animal xenograft models, primary models and patient derived samples, aiding subversion of traditional biology paradigms, and enhancing comprehension across conventional length and temporal scales Coverage includes novel applications in targeted drugs, polypharmacology, network pharmacology and other related drug development arenas - helping researchers in pancreatic cancer drug discovery Summarizes many relevant computational and clinical references from fast-evolving literature Comprehensive glossary helps newer readers understand technical terms and specialized nomenclature

Principles of Molecular Diagnostics and Personalized Cancer Medicine

Principles of Molecular Diagnostics and Personalized Cancer Medicine
Author: Dongfeng Tan,Henry T. Lynch
Publsiher: Lippincott Williams & Wilkins
Total Pages: 992
Release: 2012-12-07
ISBN 10: 1469820641
ISBN 13: 9781469820644
Language: EN, FR, DE, ES & NL

Principles of Molecular Diagnostics and Personalized Cancer Medicine Book Review:

The role of molecular genetics in the treatment of malignancy continues to grow at an astonishing rate. Today’s subspecialized multidisciplinary approach to oncology has incorporated advances in targeted molecular therapy, prognosis, risk assessment, and prevention—all based at least in part on molecular diagnostics and imaging. Inside this cutting-edge resource, readers will explore broad, comprehensive perspectives on the current trends in molecular diagnosis of cancer and personalized cancer medicine. Authoritative discussions share insights from noted experts in cancer research, clinical trials, molecular diagnostics, personalized therapy, bioinformatics, and federal regulations. From the basic mechanisms of carcinogenesis to the most advanced molecular screening, staging, and treatment technologies, readers will discover clear and straightforward discussions directly relevant to patient diagnosis and care.

Pancreatic Cancer

Pancreatic Cancer
Author: Howard Reber
Publsiher: Springer Science & Business Media
Total Pages: 347
Release: 2012-12-06
ISBN 10: 1461218101
ISBN 13: 9781461218104
Language: EN, FR, DE, ES & NL

Pancreatic Cancer Book Review:

A distinguished panel of world authorities reviews the current state of today's understanding, diagnosis, and treatment of pancreatic cancer. Their cutting-edge reviews discuss both medical and surgical modalities and include numerous insights into the basic molecular processes underlying the disease. Among the key topics covered are the prospects for early diagnosis using molecular techniques, the latest diagnostic and therapeutic methods, the role of laparoscopy (diagnostic and therapeutic), and nonsurgical treatment. The reviewers also address the future possibilities for clinical advances, quality of life concerns, and the value of the Japanese "extended Whipple resection." Pancreatic Cancer will become the new standard reference for all clinicians who diagnose and treat this disease, as well as for basic scientists needing a summary of the many recent advances. i

Theranostic Approach for Pancreatic Cancer

Theranostic Approach for Pancreatic Cancer
Author: Ganji Purnachandra Nagaraju,Sarfraz Ahmad
Publsiher: Academic Press
Total Pages: 410
Release: 2019-08-19
ISBN 10: 0128194588
ISBN 13: 9780128194584
Language: EN, FR, DE, ES & NL

Theranostic Approach for Pancreatic Cancer Book Review:

Theranostic Approach for Pancreatic Cancer modulates the biologic properties of stroma in pancreatic cancer by targeting the several chemotherapy resistance mechanisms to impede their malignant property through introducing new strategies and drugs for tackling the disease. It brings information about ongoing research as well as clinical data about pancreatic cancer and provides detailed descriptions about diagnostic and therapeutic options for easy understanding. The book discusses several topics related to pancreatic cancer, such as stem cells, drug resistance and pancreatic tumor microenvironment, the latest developments in chemotherapy for metastatic cancer and chemoprevention, and epigenome as a therapeutic strategy. Additionally, it encompasses a discussion on theranostic clinical applications for personalized treatment and management of pancreatic cancer. The book is a valuable resource for cancer researchers, oncologists, and several members of the biomedical field who need to understand more about the diagnosis and treatment of pancreatic cancer. Provides information on the roadblocks of chemotherapy in patients with newly diagnosed and metastatic pancreatic cancer“/li> Discusses treatment options available currently and prospective options for the future Focuses especially on stroma, tumor microenvironment, stem cells, stellate cells, transcription factors, growth factors, and important signaling pathways as already tested types of treatment

Molecular Pathology and Diagnostics of Cancer

Molecular Pathology and Diagnostics of Cancer
Author: Domenico Coppola
Publsiher: Springer Science & Business Media
Total Pages: 601
Release: 2013-11-29
ISBN 10: 9400771924
ISBN 13: 9789400771925
Language: EN, FR, DE, ES & NL

Molecular Pathology and Diagnostics of Cancer Book Review:

Molecular pathology is based on the emergence of new techniques that greatly enhance the diagnostic accuracy when facing with challenging differential diagnoses. In addition, new molecular techniques are entering the clinical arena for their value in predicting therapy response and tumor prognosis. This book provides a guide for the practicing pathologist and for both pathology residents and fellows during the daily sign-out of challenging cases. The book is organized by anatomical systems and provides a detailed description of molecular tests that may help in the diagnosis. Furthermore, a description of the current molecular tests required to identify patients for treatment is offered. The application of molecular pathology techniques to the clinical practice has already shown its usefulness and the number of such tests is growing exponentially as more molecular targets are discovered. Molecular Pathology and Diagnostics of Cancer will give practicing and training pathologists an up-to date resource to guide the correct management of pathology cases requiring molecular testing.

Conquering RAS

Conquering RAS
Author: Asfar Azmi
Publsiher: Academic Press
Total Pages: 294
Release: 2016-08-11
ISBN 10: 0128035412
ISBN 13: 9780128035412
Language: EN, FR, DE, ES & NL

Conquering RAS Book Review:

Conquering RAS: From Biology to Cancer Therapy provides introductory knowledge on how modern RAS biology is taking shape in light of newer technological development. Each chapter is written in a manner that emphasizes simplicity and readability for both new investigators and established researchers. While RAS biology has been intensively studied for more than three decades, we are yet to see any effective therapeutics that could interfere in the signaling cascade regulated by this master oncogene. The book covers topics ranging from basic RAS biology, to translational biology and drug discovery applications. These topics will be appealing to basic researchers working in labs who seek deeper understanding of the modern concepts in RAS research. On the other side, the oncologist at the patient’s bedside will find the book useful as they routinely face the daunting task of treating patients that predominantly have a disease driven by oncogenic KRAS. Brings together wide ranging topics in RAS basic and translational biology for the scientific and clinical communities Showcases recent advancements in RAS research under one comprehensive volume Includes video clips, color illustrations, and important website links to facilitate a clear understanding of RAS in cancer research

Animal Models in Cancer Drug Discovery

Animal Models in Cancer Drug Discovery
Author: Asfar Azmi,Ramzi M. Mohammad
Publsiher: Academic Press
Total Pages: 470
Release: 2019-04-16
ISBN 10: 0128147059
ISBN 13: 9780128147054
Language: EN, FR, DE, ES & NL

Animal Models in Cancer Drug Discovery Book Review:

Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery. Areas covered include up to date information on latest organoid derived models and newer genetic models. Additionally, the book discusses humanized animal tumor models for cancer immunotherapy and how they leverage personalized therapies. The chapter on larger animal, canine models and their use in and their use in pre-investigational new drug (pre-IND) development makes the volume unique. Unlike before, the incorporation of several simplified protocols, breeding methodologies, handling and assessment procedures to study drug intervention makes this book a must read. Animal Models in Cancer Drug Discovery is a valuable resource for basic and translational cancer researchers, drug discovery researchers, contract research organizations, and knowledge seekers at all levels in the biomedical field. Encompasses discussions on innovative animal models, xenograft, genetic models, primary models, organoid systems, humanized and other models in modern biology paradigms that are enhancing research in the field of drug discover Covers the use of these models in personalized medicine, immunotherapy, toxicology, pre-IND assessments and related drug development arenas Presents protocols, procedures, and a comprehensive glossary to help new readers understand technical terms and specialized nomenclature

Molecular Diagnostics in Cancer Patients

Molecular Diagnostics in Cancer Patients
Author: Kamla Kant Shukla,Praveen Sharma,Sanjeev Misra
Publsiher: Springer
Total Pages: 341
Release: 2019-03-28
ISBN 10: 9789811358760
ISBN 13: 9811358761
Language: EN, FR, DE, ES & NL

Molecular Diagnostics in Cancer Patients Book Review:

This book aims to bring together a broad variety of examples of the role of pharmacogenomics in current drug development, uncovering dynamic concentration-dependent drug responses on biological systems to understand pharmacodynamics responses in human cancer where genetic lesions serve as tumor markers and provide a basis for cancer diagnosis. The book describes methods and protocols applied in molecular diagnostics. It offers pathologists and researchers providing molecular diagnostic services an array of the most recent and readily accessible reference to compare methods and techniques. Highlights include the molecular diagnosis of genetic aberrations by quantitative polymerase reaction (qPCR), sequence-specific oligonucleotide arrays, next-generation sequencing (NGS), CGH arrays-and methodologies directed at the detection of epigenetic events, high-throughput nucleic acid and protein arrays, direct sequencing and FISH-based methodologies, currently used in the diagnosis of solid tumors. The book also includes an innovative line of treatment in relation to the molecular prognosis, diagnosis and pharmacogenomics in the actual practice of clinical findings at molecular levels. The book covers the applications of numerous genetic testing methodologies; in approximately the chronological order of discovery and high-throughput diagnosis using advanced genomic approaches to identify such genes, in the search for novel drug targets and/or key determinants of drug reactions. It also promotes a wider understanding of molecular diagnostics among physicians, medical students, and scientists in academics, industry and corporate world.

Clinical Molecular Diagnostics

Clinical Molecular Diagnostics
Author: Shiyang Pan,Jinhai Tang
Publsiher: Springer Nature
Total Pages: 889
Release: 2021-07-08
ISBN 10: 9811610371
ISBN 13: 9789811610370
Language: EN, FR, DE, ES & NL

Clinical Molecular Diagnostics Book Review:

This book covers the discovery of molecular biomarkers, the development of laboratory testing techniques and their clinical applications, focusing on basic research to clinical practice. It introduces new and crucial knowledge and ethics of clinical molecular diagnosis. This book emphasizes the applications of clinical molecular diagnostic test on health management, especially from different diseased organs. It lets readers to understand and realize precision healthcare.

Molecular Diagnostics of Cancer

Molecular Diagnostics of Cancer
Author: Christoph Wagener,Siegfried Neumann
Publsiher: Springer Science & Business Media
Total Pages: 223
Release: 2012-12-06
ISBN 10: 3642775217
ISBN 13: 9783642775215
Language: EN, FR, DE, ES & NL

Molecular Diagnostics of Cancer Book Review:

Present and potential future applications of new diagnostic strategies basedon the direct or indirect detection of cancer genes are delineated in this volume. Among the methodological aspects covered are enzymatic target amplification by the polymerase chain reaction and related techniques, DNA fingerprinting, transfer of putative cancer genes in appropriate receipient cells, and recent developments inthe application of monoclonal antibodies in immunohistochemistry and immunoscintigraphy. The diagnostic and functional implications of mutations in cancer genes such as ras and p53 are described. The characterization of cancer genes and their products is correlated with growth control anddissemination of tumour cells by in vitro or clinical evidence. The contributions in the present volume uptdate the information available on established or newly described cancer genes, and may help manage the transition from basic research to clinical practice.

Diagnostic Molecular Pathology

Diagnostic Molecular Pathology
Author: William B. Coleman,Gregory J. Tsongalis
Publsiher: Academic Press
Total Pages: 582
Release: 2016-10-05
ISBN 10: 0128011572
ISBN 13: 9780128011577
Language: EN, FR, DE, ES & NL

Diagnostic Molecular Pathology Book Review:

Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing is organized around disease types (genetic disease, infectious disease, neoplastic disease, among others). In each section, the authors provide background on disease mechanisms and describe how laboratory testing is built on knowledge of these mechanisms. Sections are dedicated to general methodologies employed in testing (to convey the concepts reflected in the methods), and specific description of how these methods can be applied and are applied to specific diseases are described. The book does not present molecular methods in isolation, but considers how other evidence (symptoms, radiology or other imaging, or other clinical tests) is used to guide the selection of molecular tests or how these other data are used in conjunction with molecular tests to make diagnoses (or otherwise contribute to clinical workup). In addition, final chapters look to the future (new technologies, new approaches) of applied molecular pathology and how discovery-based research will yield new and useful biomarkers and tests. Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing contains exercises to test readers on their understanding of how molecular diagnostic tests are utilized and the value of the information that can be obtained in the context of the patient workup. Readers are directed to an ancillary website that contains supplementary materials in the form of exercises where decision trees can be employed to simulate actual clinical decisions. Focuses on the menu of molecular diagnostic tests available in modern molecular pathology or clinical laboratories that can be applied to disease detection, diagnosis, and classification in the clinical workup of a patient Explains how molecular tests are utilized to guide the treatment of patients in personalized medicine (guided therapies) and for prognostication of disease Features an ancillary website with self-testing exercises where decision trees can be employed to simulate actual clinical decisions Highlights new technologies and approaches of applied molecular pathology and how discovery-based research will yield new and useful biomarkers and tests

Role of RNA in Molecular Diagnostics of Cancer

Role of RNA in Molecular Diagnostics of Cancer
Author: Cesar Wong,William Cho,Lawrence Wing Chi Chan
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2020-07-01
ISBN 10: 2889638138
ISBN 13: 9782889638130
Language: EN, FR, DE, ES & NL

Role of RNA in Molecular Diagnostics of Cancer Book Review:

Molecular Pathology An Update An Issue of the Clinics in Laboratory Medicine Ebook

Molecular Pathology  An Update  An Issue of the Clinics in Laboratory Medicine  Ebook
Author: Martin H. Bluth
Publsiher: Elsevier Health Sciences
Total Pages: 249
Release: 2018-05-23
ISBN 10: 0323610730
ISBN 13: 9780323610735
Language: EN, FR, DE, ES & NL

Molecular Pathology An Update An Issue of the Clinics in Laboratory Medicine Ebook Book Review:

This updated issue of Clinics in Laboratory Medicine, edited by Martin H. Bluth, will focus on Molecular Pathology. Topics include, but are not limited to, The Impact of Molecular Pathology on the Practice of Pathology; Molecular pathology techniques; Clinical Implication of MicroRNAs in Molecular Pathology; Diagnostic Molecular Microbiology; Molecular Pathology in Transfusion Medicine; Molecular Diagnosis of Hematopoietic Neoplasms; Molecular Diagnostics in Colorectal Carcinoma; Molecular Diagnostics in the Neoplasms of Small Intestine and Appendix; Molecular Diagnostics in Esophageal and Gastric Neoplasms; Molecular Diagnostics in the Neoplasms of the Pancreas, Liver, Gall Bladder, and Extrahepatic Biliary Tract; Current Applications of Molecular Genetic Technologies to the Diagnosis and Treatment of Cutaneous Melanocytic Neoplasms; Breast Carcinoma; and Gynecologic Cancers.

Diseases of the Pancreas

Diseases of the Pancreas
Author: Hans Günther Beger,Seiki Matsuno,John L. Cameron
Publsiher: Springer Science & Business Media
Total Pages: 949
Release: 2008-01-08
ISBN 10: 354028656X
ISBN 13: 9783540286561
Language: EN, FR, DE, ES & NL

Diseases of the Pancreas Book Review:

This book is based on the latest comprehensive data about molecular mechanism of acute pancreatitis, chronic pancreatitis and pancreatic cancer. The diagnostic techniques including histology, radiology, sonography etc. are based on the sensitivity and specificity of the respective methods. Special focus is given to the indication and contraindication to surgical techniques. The book contains specific treatment modality and results for the first time after long-term outcome evaluation. There is detailed description of diagnosis and treatment, and the book is abundantly illustrated with approximately 300 color illustrations.

Cystic Tumors of the Pancreas

Cystic Tumors of the Pancreas
Author: Marco Del Chiaro,Stephan L. Haas,Richard D. Schulick
Publsiher: Springer
Total Pages: 181
Release: 2016-07-14
ISBN 10: 3319318829
ISBN 13: 9783319318820
Language: EN, FR, DE, ES & NL

Cystic Tumors of the Pancreas Book Review:

This book provides a detailed, up-to-date overview of cystic tumors of the pancreas, with coverage of all aspects of diagnosis and treatment (medical, endoscopic, and surgical). After opening chapters on pathology and classification, cytology, molecular biology, and epidemiology, the role of each of the relevant diagnostic methods is carefully examined. The treatment-related chapters describe surgical approaches, including minimally invasive surgery, as well as ablation modalities and chemo-radiotherapy. Thorough guidance is also provided specifically on the management of cystic tumors in high-risk cases and on follow-up. The authors are global opinion leaders in their field who have contributed cutting-edge chapters, with emphasis on clear diagnostic and therapeutic algorithms and with numerous supporting tables and illustrations. Owing to the widespread use of imaging modalities, clinicians are being confronted by an increasing number of patients with cystic tumors of the pancreas, ranging from benign cysts to metastasized malignancies. The widening spectrum of available diagnostic measures has resulted in controversy over the choice of further means of investigation when cystic changes are encountered, and the growth in therapeutic options has similarly been accompanied by considerable debate over their use. Against this background, Cystic Tumors of the Pancreas will be a valuable source of relevant information for both clinicians and surgeons and will also be of interest to radiologists, pathologists, and basic scientists.

SEER Surveillance Epidemiology and End Results Program

SEER  Surveillance  Epidemiology  and End Results Program
Author: SEER Program (National Cancer Institute (U.S.))
Publsiher: Unknown
Total Pages: 8
Release: 2000
ISBN 10: 1928374650XXX
ISBN 13: UOM:39015062409936
Language: EN, FR, DE, ES & NL

SEER Surveillance Epidemiology and End Results Program Book Review:

Applications of Biotechnology in Oncology

Applications of Biotechnology in Oncology
Author: Kewal K. Jain
Publsiher: Springer Science & Business Media
Total Pages: 855
Release: 2013-11-19
ISBN 10: 1461492459
ISBN 13: 9781461492450
Language: EN, FR, DE, ES & NL

Applications of Biotechnology in Oncology Book Review:

Applications of Biotechnology in Oncology collects key writings by Kewal K. Jain on the most important contributions of biotechnology to cancer research, particularly to the molecular diagnosis of cancer and drug delivery in cancer for personalized management of patients. Basics of various “omics” technologies and their application in oncology are described as oncogenomics and oncoproteomics. This detailed volume also explores molecular diagnostics, nanobiotechnology, cell and gene therapies, as well as personalized oncology. With approximately one thousand selected references from recent literature on this topic and numerous tables and figures, Applications of Biotechnology in Oncology serves as an ideal reference for oncologists, scientists involved in research on cancer biology, and physicians in various specialties who deal with cancer.

Cancer Genetics

Cancer Genetics
Author: Stephen B. Gruber
Publsiher: Unknown
Total Pages: 384
Release: 2006-10-01
ISBN 10: 9780387304588
ISBN 13: 0387304584
Language: EN, FR, DE, ES & NL

Cancer Genetics Book Review:

Cancer Genetics provides the reader with an overview of the fundamentals of cancer genetics which includes information on the genetic basis of cancer, molecular diagnostics, cancer cytogenetics, principles of genetic counseling and physical diagnosis, and cancer risk assessment. In addition, this volume will cover the clinical management of familial cancer syndromes including retinoblastoma, Wilm's tumor, neuroblastoma, colorectal cancer, breast and ovarian cancers, prostate cancer, melanoma, pancreatic cancer, multiple endocrine neoplasia, and neurofibromatosis as well as some uncommon cancer syndromes. It will also focus on cancer as a complex genetic trait.

Oncogenomics

Oncogenomics
Author: Franco Dammacco,Franco Silvestris
Publsiher: Academic Press
Total Pages: 718
Release: 2018-10-30
ISBN 10: 0128117869
ISBN 13: 9780128117866
Language: EN, FR, DE, ES & NL

Oncogenomics Book Review:

Oncogenomics: From Basic Research to Precision Medicine offers a thorough survey of precision medicine and its diagnostic and therapeutic applications in oncology. Gathering contributions from leading international researchers in the field, chapters examine recent translational advances in oncogenomic methods and technologies, detailing novel molecular classifications of tumors as well as diagnostic and prognostic biomarkers for various types of cancers including pancreatic, gastrointestinal, breast, hematological, lung, osteotropic, genitourinary, and skin cancers. This book provides a foundation for clinical oncologists, human geneticists, and physicians to develop new targeted cancer treatments and incorporate genomic medicine into clinical practice, with particular attention paid to noninvasive diagnostic techniques such as the liquid biopsy and molecular characterization of solid malignancies. Provides clinical oncologists, human geneticists, physicians, and students with a thorough understanding of current diagnostic and prognostic applications of genomic methods and technologies to a variety of solid malignancies Employs current knowledge in oncogenomics towards developing therapeutic interventions for various cancer types Features a team of internationally recognized researchers and physicians in clinical oncology, oncogenomics and precision medicine