Molecular Aspects of Neurodegeneration Neuroprotection and Regeneration in Neurological Disorders

Molecular Aspects of Neurodegeneration  Neuroprotection  and Regeneration in Neurological Disorders
Author: Akhlaq A. Farooqui
Publsiher: Academic Press
Total Pages: 400
Release: 2020-09-07
ISBN 10: 0128217014
ISBN 13: 9780128217016
Language: EN, FR, DE, ES & NL

Molecular Aspects of Neurodegeneration Neuroprotection and Regeneration in Neurological Disorders Book Review:

Molecular Aspects of Neurodegeneration, Neuroprotection, and Regeneration in Neurological Disorders presents readers with comprehensive and cutting-edge information on the neurochemical mechanisms of various types of neurological disorders. The book covers information on signal transduction processes associated with neurochemistry of neurological disorders, including neurodegenerative, neurotraumatic, and neuropsychiatric disorders. The book also discusses risk factors, symptoms, pathogenesis, biomarkers, and the potential treatments of neurological disorders. The comprehensive information in this monograph may not only help in early detection of various neurological disorders, but will also promote the discovery of new drugs. Provides a comprehensive overview of the molecular aspects of neurodegeneration, neuroprotection, and neuro-regeneration, along with therapeutic strategies for various types of neurological disorders Provides cutting-edge research information on the signal transduction processes associated with the neurochemistry of neurological disorders Discusses risk factors, symptoms, pathogenesis, biomarkers, and the potential for treatments of neurological disorders

Molecular Aspects of Neurodegeneration and Neuroprotection

Molecular Aspects of Neurodegeneration and Neuroprotection
Author: Akhlaq A. Farooqui,Tahira Farooqui
Publsiher: Bentham Science Publishers
Total Pages: 146
Release: 2011-01-26
ISBN 10: 1608050920
ISBN 13: 9781608050925
Language: EN, FR, DE, ES & NL

Molecular Aspects of Neurodegeneration and Neuroprotection Book Review:

"Neurodegenerative diseases are a complex heterogeneous group of diseases associated with site-specific premature and slow death of certain neuronal populations in brain and spinal cord tissues. For example, in Alzheimer disease, neuronal degeneration occu"

Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases

Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases
Author: Akhlaq A. Farooqui
Publsiher: Springer Science & Business Media
Total Pages: 401
Release: 2010-09-02
ISBN 10: 1441966528
ISBN 13: 9781441966520
Language: EN, FR, DE, ES & NL

Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases Book Review:

Collectively, neurodegenerative diseases are characterized by chronic and progressive loss of neurons in discrete areas of the brain, producing debilitating symptoms such as dementia, loss of memory, loss of sensory or motor capability, decreased overall quality of life eventually leading to premature death. Two types of cell death are known to occur during neurodegeneration: (a) apoptosis and (b) necrosis. The necrosis is characterized by the passive cell swelling, intense mitochondrial damage with rapid loss of ATP, alterations in neural membrane permeability, high calcium influx, and disruption of ion homeostasis. This type of cell death leads to membrane lysis and release of intracellular components that induce inflammatory reactions. Necrotic cell death normally occurs at the core of injury site. In contrast, apoptosis is an active process in which caspases (a group of endoproteases with specificity for aspartate residues in protein) are stimulated. Apoptotic cell death is accompanied by cell shrinkage, dynamic membrane blebbing, chromatin condensation, DNA laddering, loss of phospholipids asymmetry, low ATP levels, and mild calcium overload. This type of cell death normally occurs in penumbral region at the ischemic injury site and in different regions in various neurodegenerative diseases.

Ischemic and Traumatic Brain and Spinal Cord Injuries

Ischemic and Traumatic Brain and Spinal Cord Injuries
Author: Akhlaq A. Farooqui
Publsiher: Academic Press
Total Pages: 484
Release: 2018-03-21
ISBN 10: 0128135972
ISBN 13: 9780128135976
Language: EN, FR, DE, ES & NL

Ischemic and Traumatic Brain and Spinal Cord Injuries Book Review:

Ischemic and Traumatic Brain and Spinal Cord Injuries: Mechanisms and Potential Therapies presents readers with comprehensive and cutting-edge information on molecular mechanisms, including the signal transduction processes associated with neurodegeneration and neuroprotection in ischemic, spinal cord, severe and mild brain injuries. The book also covers the molecular mechanisms of drugs used for the treatment of neurotraumatic disease. Chapters are organized by molecular aspects and neuroprotective strategies by disease, including ischemic injury, spinal cord injury, traumatic brain injury, and chronic traumatic encephalopathy. The book integrates and consolidates knowledge on neurotraumatic diseases, with the hope of bringing forth more dramatic advances and developments, not only on molecular mechanisms, but also on the causes of, and treatments for, neurotraumatic diseases. Offers a clearly written, logically organized, comprehensive overview on the molecular aspects of risk factors, pathogenesis, biomarkers, and therapeutic strategies for ischemic, spinal cord, severe and mild brain injuries Provides cutting-edge research information on the signal transduction processes associated with neurodegeneration and neuroprotection in ischemic, spinal cord, severe and mild brain injuries Presents chapters that are organized by molecular aspects and neuroprotective strategies by disease, including ischemic injury, spinal cord injury, traumatic brain injury, and chronic traumatic encephalopathy

Neuroinflammation Resolution and Neuroprotection in the Brain

Neuroinflammation  Resolution  and Neuroprotection in the Brain
Author: Akhlaq A. Farooqui
Publsiher: Academic Press
Total Pages: 332
Release: 2021-10-01
ISBN 10: 032388461X
ISBN 13: 9780323884617
Language: EN, FR, DE, ES & NL

Neuroinflammation Resolution and Neuroprotection in the Brain Book Review:

Neuroinflammation, Resolution, and Neuroprotection in the Brain discusses the molecular aspects of neuroinflammation in neurological disorders. The book examines the effect of diet and exercise on neuroinflammatory diseases. Chapters focus on bioactive lipids, cytokines and chemokines, as well as the involvement of neuroinflammation, resolution and neuroprotection in neurotraumatic diseases, neurodegenerative diseases and neuropsychiatric diseases. The comprehensive information in this monograph will help readers understand molecular cross-talk among mediators of phospholipid, sphingolipid and cholesterol metabolism. The book's goal is to jumpstart more studies on molecular mechanisms and the therapeutic aspects of neurological disorders in human subjects. Discusses the molecular aspects of neuroinflammation, resolution and neuroprotection Examines the role of diet and exercise on neuroinflammatory diseases Provides cutting-edge research on signal transduction processes Explores the treatment of neurological disorders caused by neuroinflammation

Molecular Diagnostics in the Detection of Neurodegenerative Disorders

Molecular Diagnostics in the Detection of Neurodegenerative Disorders
Author: Megha Agrawal,William C. Cho
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2017-07-04
ISBN 10: 2889451941
ISBN 13: 9782889451944
Language: EN, FR, DE, ES & NL

Molecular Diagnostics in the Detection of Neurodegenerative Disorders Book Review:

Neurodegeneration is characterized by the progressive loss of neural tissue that result in various neurodegeneration-initiated cerebral failures and complex diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease. All these medical conditions are accompanied by the disruption of blood-brain barrier (BBB). The BBB is an interface, separating the brain from the circulatory system and protecting the central nervous system from potentially harmful chemicals while regulating transport of essential molecules and maintaining a stable environment. Owing to the inability of the neurons to regenerate on their own after neurodegeneration or severe damage to the neural tissue, neurodegenerative disorders do not have natural cures on their own. Neuroregeneration is a viable way to curb neurodegeneration. One of the current approaches is stem cell-based therapy that has been shown to be potentially helpful for the application of neuronal cell replacement for neuroregeneration. It is vital that the neurodegenerative disorder being detected at an early stage as it can provide a chance for treatment that may be helpful to prevent further progression of the fatal disease. Thus, research has focused on developing effective non-invasive diagnostic methods for early detection of these disorders. Molecular diagnostics can provide a powerful method to detect and diagnose various neurological disorders. Such diagnosis can enhance early detection, provide subsequent medical counsel based on medical pathway, as well as to gain better insight of neurogenesis and hopefully eventual cure of the neurodegenerative diseases. With research reports, reviews, mini-reviews and commentary, this research topic covers a wide range of areas in neurodegeneration research, including diagnosis and prognosis; regulating central nervous system; biomarkers and brain injury induced neurobehavioral outcomes among other timely reports on neurodegeneration.

Neuroprotection in Alzheimer s Disease

Neuroprotection in Alzheimer s Disease
Author: Illana Gozes
Publsiher: Academic Press
Total Pages: 342
Release: 2016-12-30
ISBN 10: 0128037121
ISBN 13: 9780128037126
Language: EN, FR, DE, ES & NL

Neuroprotection in Alzheimer s Disease Book Review:

Neuroprotection in Alzheimer’s Disease offers a translational point-of-view from both basic and clinical standpoints, putting it on the cusp for further clinical development with its emphasis on nerve cell protection, including the accumulation of knowledge from failed clinical trials and new advances in disease management. This book brings together the latest findings, both basic, and clinical, under the same cover, making it easy for the reader to obtain a complete overview of the state-of-the-field and beyond. Alzheimer's disease is the most common form of dementia, accounting for 60 to 80 percent of dementia cases. It is a progressive brain disease that slowly destroys memory, thinking skills, and eventually, even the ability to carry out the simplest tasks. It is characterized by death of synapses coupled to death nerve cells and brain degeneration which is manifested by loss of cognitive abilities. Understanding neuroprotection in Alzheimer’s disease will pave the path to better disease management and novel therapeutics. Comprehensive reference detailing neuroprotection in Alzheimer’s Disease, with details on nerve cell protection and new advances in disease management Combines the knowledge and points-of-view of both medical doctors and basic scientists, putting the subject at the forefront for further clinical development Edited by one of the leading researchers in Alzheimer’s Disease

Neuroprotection

Neuroprotection
Author: Mathias Bähr
Publsiher: John Wiley & Sons
Total Pages: 390
Release: 2006-03-06
ISBN 10: 3527604316
ISBN 13: 9783527604319
Language: EN, FR, DE, ES & NL

Neuroprotection Book Review:

In this first book to cover model systems, molecular mechanisms and clinical trials all in one volume internationally renowned scientists and clinicians provide a comprehensive treatment of neuroprotective strategies for all important neurological disorders. Following an overview of neurodegenerative, traumatic, and ischemic disorders, the book goes on to cover in vitro and animal model systems as well as cellular and molecular mechanisms. An extremely helpful analysis of clinical studies explains reasons for their success and failure, and the whole is rounded off with a look at the current challenges and hopes for the development of effective treatment strategies in the future.

Exploring Molecular and Cellular Strategies for Neuroprotection and Neuroregeneration in Multiple Sclerosis

Exploring Molecular and Cellular Strategies for Neuroprotection and Neuroregeneration in Multiple Sclerosis
Author: Martin Short
Publsiher: Unknown
Total Pages: 570
Release: 2015
ISBN 10: 1928374650XXX
ISBN 13: OCLC:1011514170
Language: EN, FR, DE, ES & NL

Exploring Molecular and Cellular Strategies for Neuroprotection and Neuroregeneration in Multiple Sclerosis Book Review:

Multiple Sclerosis (MS) is an incurable neurological condition that affects close to 1 in 1000 Australians. Research into the complex aetiology and pathophysiology of MS is rapidly advancing. Many new treatments targeting the immune system are now available and can partially prevent damage caused by inflammation. However, all patients have a degree of axonal loss and neurodegeneration that can contribute to long-term disability. So far, no treatment has demonstrated an ability to directly protect the central nervous system (CNS) of MS patients from axonal injury or neurodegeneration. No treatment has shown to remyelinate or regenerate injured tissue in clinical trials. There is therefore a great demand for a therapy that can not only modulate the immune system but also protect the brain from axonal injury and facilitate repair processes. The aim of this thesis was to explore potential therapeutic approaches to neuroprotection and neuroregeneration in Multiple Sclerosis. Direct cell replacement was assessed using bone marrow derived cells in an animal model of Multiple Sclerosis, experimental autoimmune encephalomyelitis (EAE). The ability of mesenchymal stem cells (MSCs) and amnion epithelial cells (AECs) to protect human neural stem cells from oxidative stress injury and to differentiate through the production of neurotrophic factors was examined in vitro. Finally, several cytoskeletal proteins important for axonal growth were characterised. Their relationship with the Nogo receptor and changes due to inflammation from EAE were investigated.The ability of bone marrow derived cells to directly replace and regenerate cells within the uninjured or inflamed brain and spinal cord was assessed in the first part of the thesis. Despite the use of a highly sensitive multi-colour flow cytometry, an insignificant number of the bone marrow derived cells transplanted into mice were able to transform into neural cells. These findings were confirmed using immunofluorescence microscopy and virtual slide imaging. Although more bone marrow derived cells migrated to the brain and spinal cord in mice with EAE than controls, they retained hematopoietic cell markers, hence confirming the lack of transformation.While bone marrow predominantly contains hematopoietic cells and their precursors, there are other cell types including MSCs that have been investigated as a possible novel therapy for Multiple Sclerosis. As well as modulating the immune system, these cells have potential for neuroprotection and regeneration. Rather than direct cell replacement, these cells possibly have their effect through the production of soluble factors. We have demonstrated that MSC express RNA for many neurotrophic factors and in particular produce IL-6, BDNF and HGF. The quantity of these factors was increased following exposure to pro-inflammatory cytokines, particularly TNF-[alpha]. In the second part of the thesis, a novel culture system in which neural stem cells (NSCs) derived from a patient with MS using induced pluripotent stem cell techniques was used to assess the ability of human MSC to protect against oxidative stress and enhance differentiation through the production of neurotrophic factors. NSCs exposed to MSC conditioned media for 5 weeks reduced the expression of GFAP expression and a low molecular weight component within the conditioned media ameliorated oxidative stress.Although bone marrow derived MSC have many attractive attributes for use as an immunomodulatory and neuroregenerative therapy in MS, the need for cell culture and expansion may limit its use. AECs are an alternative cell type obtained in large numbers from otherwise discarded placentas that has promise for use in inflammatory conditions including MS. The neuroprotective and regenerative potential in MS has not previously been examined. The ability of AECs to produce neurotrophic factors was investigated and compared with MSCs. AECs expressed fewer neurotrophic factors and did not produce IL-6, BDNF or HGF. AEC conditioned media still reduced GFAP expression in NSCs over 5 weeks of culture but appeared to increase oxidative stress and cell death. Similar to MSCs, the AEC conditioned media appeared to ameliorate the effect of an exogenous oxidative stress.While cell therapies have great potential in regenerative medicine, there are a number of other promising avenues of research. In the final part of the thesis, possible mechanisms underlying Nogo receptor mediated restriction in axonal growth have been explored. Two proteins downstream of the Nogo Receptor, CRMP-2 and cofilin were examined. Phosphorylated CRMP-2 correlated well with axonal loss in both the animal model of MS (EAE) and biopsy sections from an MS patient. Levels of phosphorylated cofilin were higher in mice lacking the Nogo receptor than the controls. Since cofilin phosphorylation is linked to axonal growth, if substantiated, these findings could potentially lead to novel and targeted therapies for regeneration in MS.This thesis has explored a range of different strategies that show promise for neuroprotection and regeneration in MS from direct cell replacement by bone marrow stem cells, the production of neurotrophic factors by MSCs and AECs, and modulation of the Nogo receptor via CRMP-2 and cofilin. Due to the great demand for neuroprotective and regenerative therapies these and other therapies are already being translated into early clinical trials. Although current immunomodulatory therapies can significantly reduce relapses and lesion load over time, a combination of immunomodulatory and neuroprotective/regenerative therapies may have a greater impact on reducing long-term disability and improve the quality of life for patients with MS.

Handbook of Innovations in Central Nervous System Regenerative Medicine

Handbook of Innovations in Central Nervous System Regenerative Medicine
Author: Antonio Salgado
Publsiher: Elsevier
Total Pages: 710
Release: 2020-06-10
ISBN 10: 0128180854
ISBN 13: 9780128180853
Language: EN, FR, DE, ES & NL

Handbook of Innovations in Central Nervous System Regenerative Medicine Book Review:

Handbook of Innovations in CNS Regenerative Medicine provides a comprehensive overview of the CNS regenerative medicine field. The book describes the basic biology and anatomy of the CNS and how injury and disease affect its balance and the limitations of the present therapies used in the clinics. It also introduces recent trends in different fields of CNS regenerative medicine, including cell transplantation, bio and neuro-engineering, molecular/pharmacotherapy therapies and enabling technologies. Finally, the book presents successful cases of translation of basic research to first-in-human trials and the steps needed to follow this path. Areas such as cell transplantation approaches, bio and neuro-engineering, molecular/pharmacotherapy therapies and enabling technologies are key in regenerative medicine are covered in the book, along with regulatory and ethical issues. Describes the basic biology and anatomy of the CNS and how injury and disease affect its balance Discusses the limitations of present therapies used in the clinics Introduces the recent trends in different fields of CNS regenerative medicine, including cell transplantation, bio and neuro-engineering, molecular/pharmacotherapy therapies, and enabling technologies Presents successful cases of translation of basic research to first-in-human trials, along with the steps needed to follow this path

Hormones in Neurodegeneration Neuroprotection and Neurogenesis

Hormones in Neurodegeneration  Neuroprotection  and Neurogenesis
Author: Achille G. Gravanis,Synthia H. Mellon
Publsiher: John Wiley & Sons
Total Pages: 404
Release: 2011-06-24
ISBN 10: 3527633979
ISBN 13: 9783527633975
Language: EN, FR, DE, ES & NL

Hormones in Neurodegeneration Neuroprotection and Neurogenesis Book Review:

As life expectancy increases and population ages, the already enormous impact of neurodegeneration on society will become even larger without better prevention and treatment. Developing strategies to prevent degeneration of neurons and to promote a healthy nervous system is, thus, critical. The development of pharmacological agents that would increase production of new neurons was recently facilitated by the identification of the hormonal regulators of various steps of adult neurogenesis. The proposed book is writen by a group of top world experts involved in the study of the mechanisms of hormonal control of brain damage and repair. The effects of thyroid and steroid hormones (estrogens, androgens, progestins, gluco-mineralo-corticoids, various neurosteroids) or polypeptide hormones (CRF, urocortins, somatostastin, GH/IGF, leptin, prolactin, PACAP, erythropoetin) on neuronal survival and neurogenesis in various neurodegenerative conditions and in brain aging will be discussed in detail. The proposed book is unique because it gives a comprehensive account of the neuroprotective and neurogenic effects of steroid and polypeptide hormones. Furthermore, new pharmacological approaches for treatment of neurodegenerative conditions are presented, based on the neuroprotective and neurogenic properties of natural and synthetic hormones.

Handbook of Neurochemistry and Molecular Neurobiology

Handbook of Neurochemistry and Molecular Neurobiology
Author: Naren L. Banik,Swapan K. Ray,Abel Lajtha
Publsiher: Springer Science & Business Media
Total Pages: 669
Release: 2008-11-25
ISBN 10: 038730343X
ISBN 13: 9780387303437
Language: EN, FR, DE, ES & NL

Handbook of Neurochemistry and Molecular Neurobiology Book Review:

Therapeutic approaches in spinal cord injury.- Cell death and tissue degeneration in traumatic brain injury.- neurotransmitters and electrophysiology in brain injury.- neurotransmitters and electrophysiology in brain injury.- Parkinsonism in the MPTP model.- EAE Demyelination.- EAE Neurodegeneration.- Cataract.- Uveitis.- Optic neuritis.- GBS/peripherial neuropathy, paraproteinemia.- Brain Tumor(Tumor Mechanisma).- Brain Tumor and angiogenesis.- SCIDS.- Phenylketone urea and mental retardation.- Neurofibromatosis.- BBB.- Muscular dystrophy.- Stracher.- Diabetic neuropathy/retinopathy/cataract.- Peroxisomes and adrenoleukodystrophy ALD.- Neuroprotection.- NFkB (Inflammation and spinal cord injury).- spinal cord injury and traumatic brain injury.- free radicals and neuroprotection.- Traumatic brain injury.- white matter degeneration.- Mitochondrial membrane defects.- Encephalomyopathies.- metal induced neurodegenaration.- neurometals in protein misfolding neurodegenerative diseases.- hyperammonemia.- kyneurenines in the brain preclinical and clinical studies, therapeutic condiserations.

Neurodegeneration in Multiple Sclerosis

Neurodegeneration in Multiple Sclerosis
Author: M. Filippi,M. Rovaris,G. Comi
Publsiher: Springer Science & Business Media
Total Pages: 236
Release: 2008-02-01
ISBN 10: 8847003911
ISBN 13: 9788847003910
Language: EN, FR, DE, ES & NL

Neurodegeneration in Multiple Sclerosis Book Review:

Written by world-renowned scientists, the volume provides a state-of-the-art on the most recent MRI techniques related to MS, and it is an indispensable tool for all those working in this field. The context in which this book exists is that there is an increasing perception that modern MR methodologies should be more extensively employed in clinical trials to derive innovative information.

Nutraceuticals for Aging and Anti Aging

Nutraceuticals for Aging and Anti Aging
Author: Jayant Nemchand Lokhande,Yashwant Vishnupant Pathak
Publsiher: CRC Press
Total Pages: 750
Release: 2021-11-26
ISBN 10: 1000475964
ISBN 13: 9781000475968
Language: EN, FR, DE, ES & NL

Nutraceuticals for Aging and Anti Aging Book Review:

Aging can be perceived differently during different times in one’s life. Aging as a process not only influences medical and economic dimensions at an individual level but also at societal and national levels. Aging is a natural process; however, its standard definition in a healthcare context is yet unclear. To delay the aging process and to maintain quality of life until the end of life are two goals of prime importance. Various healthcare approaches are being developed and experimented on to best manage aging as if it is a disease. Nutraceuticals are value-added dietary supplement products and have an immense potential in altering key structures and functions of aging. Nutraceuticals can be a keystone in altering sub-normal performing physiological and metabolic systems due to aging. Nutraceuticals for Aging and Anti-Aging: Basic Understanding and Clinical Evidence addresses aging and anti-aging nutraceuticals based on 10 major challenges, such as cognitive health, malnutrition, substance abuse, bladder control, and oral health, among others. It examines how these challenges can be complemented with nutraceuticals and connects the applications with the traditional wisdom of the aging process. Key Features Examines the aging process, then recommends nutraceuticals for aging and anti-aging processes Describes the aging process from the western perspective, and Ayurvedic medicine (Indian traditional system) and traditional Chinese medicine perspectives Provides, whenever possible, the clinical evidence of the applications of nutraceuticals for aging and anti-aging This book is a valuable resource for physicians, clinical experts, pharmaceutical companies and their experts, nutrition specialists, entrepreneurs, chemists, pharmacists, food chemists-technologists, as well as researchers and post-graduate students involved in these specialties. Also available in the Nutraceuticals: Basic Research/Clinical Applications Series: Bioactive Peptides: Production, Bioavailability, Health Potential, and Regulatory Issues, edited by John O. Onuh, M. Selvamuthukumaran, and Yashwant V. Pathak (ISBN: 978-0-3675-1177-7) Nutraceuticals for Prenatal, Maternal and Offspring’s Nutritional Health, edited by Priyanka Bhatt, Maryam Sadat Miraghajani, Sarvadaman Pathak, and Yashwant V. Pathak (ISBN 978-1-1383-4582-9) Advances in Nutraceutical Applications in Cancer: Recent Research Trends and Clinical Applications, edited by Sheeba Varghese Gupta, and Yashwant V. Pathak (ISBN 978-1-1385-9391-6)

Oxidative Stress in Vertebrates and Invertebrates

Oxidative Stress in Vertebrates and Invertebrates
Author: Tahira Farooqui,Akhlaq A. Farooqui
Publsiher: John Wiley & Sons
Total Pages: 416
Release: 2011-10-24
ISBN 10: 1118148118
ISBN 13: 9781118148112
Language: EN, FR, DE, ES & NL

Oxidative Stress in Vertebrates and Invertebrates Book Review:

This volume presents a unique comparative treatment of the role oxidative stress plays in vertebrates and invertebrates in multiple organ systems with regards to cell death, development, aging, and human diseases, and anti-oxidant therapy. It offers comprehensive reviews of the current understanding of oxidative stress-mediated physiology and pathology as well as directions for future research. It also provides current information on the role of oxidative stress in neurodegenerative diseases, cardiovascular diseases, and various types of cancer mediated by oxidative stress.

Omic Studies of Neurodegenerative Disease

Omic Studies of Neurodegenerative Disease
Author: Anonim
Publsiher: Academic Press
Total Pages: 214
Release: 2015-08-25
ISBN 10: 0128016213
ISBN 13: 9780128016213
Language: EN, FR, DE, ES & NL

Omic Studies of Neurodegenerative Disease Book Review:

Omic Studies of Neurodegenerative Disease: Part A is part of a well-established international series on neuroscience that examines major areas of basic and clinical research, along with emerging and promising subfields. The book informs the reader on the current state of the studies used to evaluate the mechanisms, causes, and treatment of neurodegeneration through a combination of literature reviews and examples of current research. Provides the expertise of leading contributors in the field Demonstrates how findings in the fields of genomics, proteomics, and metabolomic studies can combined for further insights Informs the reader on the current state of the studies used to study the mechanisms, causes, and treatment of neurodegeneration through a combination of literature reviews and examples of current research

Neuroinflammation

Neuroinflammation
Author: Samuel David
Publsiher: John Wiley & Sons
Total Pages: 304
Release: 2015-03-10
ISBN 10: 1118732774
ISBN 13: 9781118732779
Language: EN, FR, DE, ES & NL

Neuroinflammation Book Review:

Neuroinflammation has long been studied for its connection to the development and progression of Multiple Sclerosis. In recent years, the field has expanded to look at the role of inflammatory processes in a wide range of neurological conditions and cognitive disorders including stroke, amyotrophic lateral sclerosis, and autism. Researchers have also started to note the beneficial impacts of neuroinflammation in certain diseases. Neuroinflammation: New Insights into Beneficial and Detrimental Functions provides a comprehensive view of both the detriments and benefits of neuroinflammation in human health. Neuroinflammation: New Insights into Beneficial and Detrimental Functions opens with two chapters that look at some fundamental aspects of neuroinflammation in humans and rodents. The remainder of the book is divided into two sections which examine both the detrimental and beneficial aspects of inflammation on the brain, spinal cord and peripheral nerves, on various disease states, and in normal aging. These sections provide a broad picture of the role neuroinflammation plays in the physiology and pathology of various neurological disorders. Providing cross-disciplinary coverage, Neuroinflammation: New Insights into Beneficial and Detrimental Functions will be an essential volume for neuroimmunologists, neurobiologists, neurologists, and others interested in the field. neurobiologists, neurologists, and others interested in the field.Neuroinflammation has long been studied for its connection to the development andprogression of Multiple Sclerosis. In recent years, the field has expanded to look at therole of inflammatory processes in a wide range of neurological conditions and cognitivedisorders including stroke, amyotrophic lateral sclerosis, and autism. Researchers havealso started to note the beneficial impacts of neuroinflammation in certain diseases.Neuroinflammation: New Insights into Beneficial and Detrimental Functions provides acomprehensive view of both the detriments and benefits of neuroinflammation inhuman health.Neuroinflammation: New Insights into Beneficial and Detrimental Functionsopens with two chapters that look at some fundamental aspects of neuroinflammationin humans and rodents. The remainder of the book is divided into two sections whichexamine both the detrimental and beneficial aspects of inflammation on the brain, spinalcord and peripheral nerves, on various disease states, and in normal aging. Thesesections provide a broad picture of the role neuroinflammation plays in the physiologyand pathology of various neurological disorders.Providing cross-disciplinary coverage, Neuroinflammation: New Insights into Beneficialand Detrimental Functions will be an essential volume for neuroimmunologists,neurobiologists, neurologists, and others interested in the field.Neuroinflammation has long been studied for its connection to the development andprogression of Multiple Sclerosis. In recent years, the field has expanded to look at therole of inflammatory processes in a wide range of neurological conditions and cognitivedisorders including stroke, amyotrophic lateral sclerosis, and autism. Researchers havealso started to note the beneficial impacts of neuroinflammation in certain diseases.Neuroinflammation: New Insights into Beneficial and Detrimental Functions provides acomprehensive view of both the detriments and benefits of neuroinflammation inhuman health.Neuroinflammation: New Insights into Beneficial and Detrimental Functionsopens with two chapters that look at some fundamental aspects of neuroinflammationin humans and rodents. The remainder of the book is divided into two sections whichexamine both the detrimental and beneficial aspects of inflammation on the brain, spinalcord and peripheral nerves, on various disease states, and in normal aging. Thesesections provide a broad picture of the role neuroinflammation plays in the physiologyand pathology of various neurological disorders.Providing cross-disciplinary coverage, Neuroinflammation: New Insights into Beneficialand Detrimental Functions will be an essential volume for neuroimmunologists,neurobiologists, neurologists, and others interested in the field.Neuroinflammation has long been studied for its connection to the development andprogression of Multiple Sclerosis. In recent years, the field has expanded to look at therole of inflammatory processes in a wide range of neurological conditions and cognitivedisorders including stroke, amyotrophic lateral sclerosis, and autism. Researchers havealso started to note the beneficial impacts of neuroinflammation in certain diseases.Neuroinflammation: New Insights into Beneficial and Detrimental Functions provides acomprehensive view of both the detriments and benefits of neuroinflammation inhuman health.Neuroinflammation: New Insights into Beneficial and Detrimental Functionsopens with two chapters that look at some fundamental aspects of neuroinflammationin humans and rodents. The remainder of the book is divided into two sections whichexamine both the detrimental and beneficial aspects of inflammation on the brain, spinalcord and peripheral nerves, on various disease states, and in normal aging. Thesesections provide a broad picture of the role neuroinflammation plays in the physiologyand pathology of various neurological disorders.Providing cross-disciplinary coverage, Neuroinflammation: New Insights into Beneficialand Detrimental Functions will be an essential volume for neuroimmunologists,neurobiologists, neurologists, and others interested in the field.Neuroinflammation has long been studied for its connection to the development andprogression of Multiple Sclerosis. In recent years, the field has expanded to look at therole of inflammatory processes in a wide range of neurological conditions and cognitivedisorders including stroke, amyotrophic lateral sclerosis, and autism. Researchers havealso started to note the beneficial impacts of neuroinflammation in certain diseases.Neuroinflammation: New Insights into Beneficial and Detrimental Functions provides acomprehensive view of both the detriments and benefits of neuroinflammation inhuman health.Neuroinflammation: New Insights into Beneficial and Detrimental Functionsopens with two chapters that look at some fundamental aspects of neuroinflammationin humans and rodents. The remainder of the book is divided into two sections whichexamine both the detrimental and beneficial aspects of inflammation on the brain, spinalcord and peripheral nerves, on various disease states, and in normal aging. Thesesections provide a broad picture of the role neuroinflammation plays in the physiologyand pathology of various neurological disorders.Providing cross-disciplinary coverage, Neuroinflammation: New Insights into Beneficialand Detrimental Functions will be an essential volume for neuroimmunologists,neurobiologists, neurologists, and others interested in the field.Neuroinflammation has long been studied for its connection to the development andprogression of Multiple Sclerosis. In recent years, the field has expanded to look at therole of inflammatory processes in a wide range of neurological conditions and cognitivedisorders including stroke, amyotrophic lateral sclerosis, and autism. Researchers havealso started to note the beneficial impacts of neuroinflammation in certain diseases.Neuroinflammation: New Insights into Beneficial and Detrimental Functions provides acomprehensive view of both the detriments and benefits of neuroinflammation inhuman health.Neuroinflammation: New Insights into Beneficial and Detrimental Functionsopens with two chapters that look at some fundamental aspects of neuroinflammationin humans and rodents. The remainder of the book is divided into two sections whichexamine both the detrimental and beneficial aspects of inflammation on the brain, spinalcord and peripheral nerves, on various disease states, and in normal aging. Thesesections provide a broad picture of the role neuroinflammation plays in the physiologyand pathology of various neurological disorders.Providing cross-disciplinary coverage, Neuroinflammation: New Insights into Beneficialand Detrimental Functions will be an essential volume for neuroimmunologists,neurobiologists, neurologists, and others interested in the field.Neuroinflammation has long been studied for its connection to the development andprogression of Multiple Sclerosis. In recent years, the field has expanded to look at therole of inflammatory processes in a wide range of neurological conditions and cognitivedisorders including stroke, amyotrophic lateral sclerosis, and autism. Researchers havealso started to note the beneficial impacts of neuroinflammation in certain diseases.Neuroinflammation: New Insights into Beneficial and Detrimental Functions provides acomprehensive view of both the detriments and benefits of neuroinflammation inhuman health.Neuroinflammation: New Insights into Beneficial and Detrimental Functionsopens with two chapters that look at some fundamental aspects of neuroinflammationin humans and rodents. The remainder of the book is divided into two sections whichexamine both the detrimental and beneficial aspects of inflammation on the brain, spinalcord and peripheral nerves, on various disease states, and in normal aging. Thesesections provide a broad picture of the role neuroinflammation plays in the physiologyand pathology of various neurological disorders.Providing cross-disciplinary coverage, Neuroinflammation: New Insights into Beneficialand Detrimental Functions will be an essential volume for neuroimmunologists,neurobiologists, neurologists, and others interested in the field.

Opportunities and Challenges of the Therapies Targeting CNS Regeneration

Opportunities and Challenges of the Therapies Targeting CNS Regeneration
Author: H.D. Perez,B. Mitrovic,A. Baron Van Evercooren
Publsiher: Springer Science & Business Media
Total Pages: 186
Release: 2007-01-19
ISBN 10: 3540276262
ISBN 13: 9783540276265
Language: EN, FR, DE, ES & NL

Opportunities and Challenges of the Therapies Targeting CNS Regeneration Book Review:

The therapeutic options for the treatment of Multiple Sclerosis (MS) and other neurodegenerative and traumatic diseases such as spinal cord injury, Alzheimer's, Parkinson's disease, etc. have experienced enormous progress over recent years. Despite these encouraging developments, available therapies are only partially effective, and the ultimate goal is still far from being attained. Improved understanding of the cellular and molecular mechanisms of the pathogenesis of neurodegeneration and demyelination has led to a variety of new therapeutic targets and approaches. In addition to modulation of the inflammatory process (MS) and classical neuroprotection (stroke, AD), therapeutic approaches focusing on active remyelinization and neuronal regeneration have become increasingly important. Based on current concepts, this book summarizes new therapeutic approaches.

Applications of Biotechnology in Neurology

Applications of Biotechnology in Neurology
Author: Kewal K. Jain
Publsiher: Springer Science & Business Media
Total Pages: 638
Release: 2013-01-05
ISBN 10: 162703272X
ISBN 13: 9781627032728
Language: EN, FR, DE, ES & NL

Applications of Biotechnology in Neurology Book Review:

Culling together excerpts from a wide range of writings by Dr. Kewal K. Jain on biotechnology topics as they relate to disorders of the nervous system, Applications of Biotechnology in Neurology covers a variety of applications for those working in life sciences and the pharmaceutical sciences, particularly those developing diagnostics and therapeutics for the nervous system. This detailed volume delves into areas such as neurobiotechnology, like neurogenomics and neuroproteomics, molecular diagnostics, various methods of improving systemic administration of drugs for targeted delivery to the nervous system, including the use of nanobiotechnology, biotechnology-based strategies and products for neuroprotection, as well as chapters on neurosurgery and personalized neurology. Thorough, cutting-edge, and thoughtfully organized, Applications of Biotechnology in Neurology serves as an ideal guide, supplemented by 75 tables and 16 figures as well as numerous references from recent literature on this topic, which are appended to each chapter.

The Metabolic Inflammatory Axis in Brain Aging and Neurodegeneration

The Metabolic Inflammatory Axis in Brain Aging and Neurodegeneration
Author: Fei Yin,Jia Yao,Roberta Diaz Brinton,Enrique Cadenas
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2017-08-16
ISBN 10: 2889452530
ISBN 13: 9782889452538
Language: EN, FR, DE, ES & NL

The Metabolic Inflammatory Axis in Brain Aging and Neurodegeneration Book Review:

Impairment of energy metabolism is a hallmark of brain aging and several neurodegenerative diseases, such as the Alzheimer’s disease (AD). Age- and disease-related hypometabolism is commonly associated with oxidative stress and they are both regarded as major contributors to the decline in synaptic plasticity and cognition. Neuroinflammatory changes, entailing microglial activation and elevated expression of inflammatory cytokines, also correlate with age-related cognitive decline. It is still under debate whether the mitochondrial dysfunction-induced metabolic deficits or the microglia activation-mediated neuroinflammation is the initiator of the cognitive changes in aging and AD. Nevertheless, multiple lines of evidence support the notion that mitochondrial dysfunction and chronic inflammation exacerbate each other, and these mechanistic diversities have cellular redox dysregulation as a common denominator. This research topic focuses on the role of a metabolic-inflammatory axis encompassing the bioenergetic activity, brain inflammatory responses and their redox regulation in healthy brain aging and neurodegenerative diseases. Dynamic interactions among these systems are reviewed in terms of their causative or in-tandem occurrence and how the systemic environment, –e.g., insulin resistance, diabetes, and systemic inflammation–, impacts on brain function.