Modeling Neuropsychiatric Disorders in Laboratory Animals

Modeling Neuropsychiatric Disorders in Laboratory Animals
Author: Kurt Leroy Hoffman
Publsiher: Woodhead Publishing
Total Pages: 324
Release: 2015-08-28
ISBN 10: 0081001061
ISBN 13: 9780081001066
Language: EN, FR, DE, ES & NL

Modeling Neuropsychiatric Disorders in Laboratory Animals Book Review:

Modeling Neuropsychiatric Disorders in Laboratory Animals serves as a guide for students and basic investigators in the fields of behavioral sciences, psychology, neuroscience, psychiatry, and other professionals interested in the use of animal models in preclinical research related to human neuropsychiatric disorders. The text focuses on the rationale and theory of using animal behavior, both pathological and normal, as a tool for understanding the neural underpinnings of neuropsychiatric disorders. Chapters contain discussions on both classical and modern views on the validation of animal models for neuropsychiatric disorders, also discussing the utility of endophenotypes in modeling neuropsychiatric disease. Subsequent chapters deal with four specific classes of disorders, including anxiety disorders, depressive disorders, obsessive-compulsive and related disorders. Final sections discuss the future for the development, validation, and use of animal models in basic and preclinical research. Focuses on the rationale and theory of using animal behavior, both pathological and normal, as a tool for understanding the neural underpinnings of neuropsychiatric disorders Serves as a guide for students and basic investigators in the fields of behavioral sciences, psychology, neuroscience, psychiatry, and other professionals Discusses specific classes of disorders, including anxiety disorders, depressive disorders, obsessive-compulsive and related disorders

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
Author: P. Michael Conn
Publsiher: Academic Press
Total Pages: 1108
Release: 2013-05-29
ISBN 10: 0124159125
ISBN 13: 9780124159129
Language: EN, FR, DE, ES & NL

Animal Models for the Study of Human Disease Book Review:

Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse. Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives and animal ethics Covers a broad range of animal models used in research for human disease

Animal Models of Neurological Disorders

Animal Models of Neurological Disorders
Author: Puneet Kumar Bansal,Rahul Deshmukh
Publsiher: Springer
Total Pages: 343
Release: 2018-01-17
ISBN 10: 9811059810
ISBN 13: 9789811059810
Language: EN, FR, DE, ES & NL

Animal Models of Neurological Disorders Book Review:

This book introduces undergraduate, postgraduate and research students and scientists to animal models of neurological disorders, along with their working principle and brief procedures. Addressing all the disorders related to the central nervous system (CNS) in a single platform, on the basis of various literature surveys it describes different procedures to induce a single disease with the help of toxins/chemicals. It also includes numerous protocols for inducing single neurological diseases, thus fulfilling an urgent need for a book that makes specific procedures for neurological disorders available, so that specific disease can be induced in laboratories according to the availability of resources. Further, it acquaints readers with the pathological changes that occur in a particular neurological disorder, which reflect specific signs and symptoms of any particular disease, and examines how they affect everyday life. It is a valuable resource for researchers aiming to eradicate or improve neurological disorders by testing the benefits of different drugs.

Model Behavior

Model Behavior
Author: Nicole C. Nelson
Publsiher: University of Chicago Press
Total Pages: 272
Release: 2018-04-04
ISBN 10: 022654611X
ISBN 13: 9780226546117
Language: EN, FR, DE, ES & NL

Model Behavior Book Review:

Mice are used as model organisms across a wide range of fields in science today—but it is far from obvious how studying a mouse in a maze can help us understand human problems like alcoholism or anxiety. How do scientists convince funders, fellow scientists, the general public, and even themselves that animal experiments are a good way of producing knowledge about the genetics of human behavior? In Model Behavior, Nicole C. Nelson takes us inside an animal behavior genetics laboratory to examine how scientists create and manage the foundational knowledge of their field. Behavior genetics is a particularly challenging field for making a clear-cut case that mouse experiments work, because researchers believe that both the phenomena they are studying and the animal models they are using are complex. These assumptions of complexity change the nature of what laboratory work produces. Whereas historical and ethnographic studies traditionally portray the laboratory as a place where scientists control, simplify, and stabilize nature in the service of producing durable facts, the laboratory that emerges from Nelson’s extensive interviews and fieldwork is a place where stable findings are always just out of reach. The ongoing work of managing precarious experimental systems means that researchers learn as much—if not more—about the impact of the environment on behavior as they do about genetics. Model Behavior offers a compelling portrait of life in a twenty-first-century laboratory, where partial, provisional answers to complex scientific questions are increasingly the norm.

Animal Models of Neurological Disease I

Animal Models of Neurological Disease  I
Author: Alan A. Boulton,Glen B. Baker,Roger F. Butterworth
Publsiher: Humana Press
Total Pages: 368
Release: 2013-08-18
ISBN 10: 9781489940223
ISBN 13: 1489940227
Language: EN, FR, DE, ES & NL

Animal Models of Neurological Disease I Book Review:

to the Animal Models Volumes This and several other volumes in the Neuromethods series will describe a number of animal models of neu- psychiatric disorders. Because of increasing public concern over the ethical treatment of animals in research, we felt it incumbent upon us to include this general preface to these volumes in order to indicate why we think further research using animals is necessary and why animal models of psychi- ric and neurologic disorders, in particular, are so important. We recognize that animals should only be used when suitable alternatives are not available. We think it self-e- dent, however, that humans can only be experimented upon in severely proscribed circumstances and alternative pro- dures using cell or tissue culture are inadequate in any models requiring assessments of behavioral change or of complex in vivo processes. However, when the distress, discomfort, or pain to the animals outweighs the anticipated gains for human welfare, then the research is not ethical and should not be carried out.

Animal and Translational Models for CNS Drug Discovery

Animal and Translational Models for CNS Drug Discovery
Author: Robert A. McArthur,Franco Borsini
Publsiher: Academic Press
Total Pages: 1376
Release: 2008-11-27
ISBN 10: 9780080920412
ISBN 13: 0080920411
Language: EN, FR, DE, ES & NL

Animal and Translational Models for CNS Drug Discovery Book Review:

Animal and Translational Models for CNS Drug Discovery combines the experience of academic, clinical and pharmaceutical neuroscientists in a unique collaborative approach to provide a greater understanding of the relevance of animal models of neuropsychiatric disorders and their role as translational tools for the discovery of CNS drugs being developed for the treatment of these disorders. The focus of this three-volume series of essays is to present a consensual picture of the translational value of animal models from leading experts actively involved in the use of animal models for understanding fundamental neurobiology of CNS disorders and the application of this knowledge to CNS drug discovery, and clinical investigators involved in clinical trials, drug development and eventual registration of novel pharmaceuticals. Each volume of the Animal and Translational Models for CNS Drug Discovery series is dedicated to the development and use of animal models in key therapeutic areas in psychiatric, neurologic and reward deficit disorders. Each volume has introductory chapters expressing the view of the role and relevance of animal models for CNS drug discovery and development from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in relevant therapeutic areas and discusses the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. The aim of this series of volumes on Animal and Translational Models for CNS Drug Discovery is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. - Provides clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery process - Critical evaluation of animal and translational models improving transition from drug discovery and clinical development - Emphasizes what results mean to the overall drug discovery process - Explores issues in clinical trial design and conductance in each therapeutic area - Each volume is available for purchase individually.

Improving the Utility and Translation of Animal Models for Nervous System Disorders

Improving the Utility and Translation of Animal Models for Nervous System Disorders
Author: Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publsiher: National Academies Press
Total Pages: 110
Release: 2013-04-25
ISBN 10: 0309266335
ISBN 13: 9780309266338
Language: EN, FR, DE, ES & NL

Improving the Utility and Translation of Animal Models for Nervous System Disorders Book Review:

Nervous system diseases and disorders are highly prevalent and substantially contribute to the overall disease burden. Despite significant information provided by the use of animal models in the understanding of the biology of nervous system disorders and the development of therapeutics; limitations have also been identified. Treatment options that are high in efficacy and low in side effects are still lacking for many diseases and, in some cases are nonexistent. A particular problem in drug development is the high rate of attrition in Phase II and III clinical trials. Why do many therapeutics show promise in preclinical animal models but then fail to elicit predicted effects when tested in humans? On March 28 and 29, 2012, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened the workshop "Improving Translation of Animal Models for Nervous System Disorders" to discuss potential opportunities for maximizing the translation of new therapies from animal models to clinical practice. The primary focus of the workshop was to examine mechanisms for increasing the efficiency of translational neuroscience research through discussions about how and when to use animal models most effectively and then best approaches for the interpretation of the data collected. Specifically, the workshop objectives were to: discuss key issues that contribute to poor translation of animal models in nervous system disorders, examine case studies that highlight successes and failures in the development and application of animal models, consider strategies to increase the scientific rigor of preclinical efficacy testing, explore the benefits and challenges to developing standardized animal and behavioral models. Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary also identifies methods to facilitate development of corresponding animal and clinical endpoints, indentifies methods that would maximize bidirectional translation between basic and clinical research and determines the next steps that will be critical for improvement of the development and testing of animal models of disorders of the nervous system.

Animal Models of Acute Neurological Injuries

Animal Models of Acute Neurological Injuries
Author: Jun Chen,Xiao-Ming Xu,Zao C. Xu
Publsiher: Springer Science & Business Media
Total Pages: 498
Release: 2008-12-16
ISBN 10: 1603271856
ISBN 13: 9781603271851
Language: EN, FR, DE, ES & NL

Animal Models of Acute Neurological Injuries Book Review:

Despite numerous recent studies and exciting discoveries in the field, only limited treatment is available today for the victims of acute neurological injuries. Animal Models of Acute Neurological Injuries provides a standardized methodology manual designed to eliminate the inconsistent preparations and variability that currently jeopardizes advances in the field. Contributed by top experts and many original developers of the models, each chapter contains a step-by-step, proven procedure and visual aids covering the most commonly used animal models of neurological injury in order to highlight the practical applications of animal models rather than the theoretical issues. This intensive volume presents its readily reproducible protocols with great clarity and consistency to best aid neuroscientists and neurobiologists in laboratory testing and experimentation. Comprehensive and cutting-edge, Animal Models of Acute Neurological Injuries is an ideal guide for scientists and researchers who wish to pursue this vital course of study with the proficiency and precision that the field requires.

Animal Models of Neurological Disease II

Animal Models of Neurological Disease  II
Author: Alan A. Boulton,Glen B. Baker,Roger F. Butterworth
Publsiher: Humana
Total Pages: 373
Release: 2013-08-11
ISBN 10: 9781489943897
ISBN 13: 1489943897
Language: EN, FR, DE, ES & NL

Animal Models of Neurological Disease II Book Review:

to the Animal Models Volumes This and several other volumes in the Neuromethods series will describe a number of animal models of neuropsychiatric disorders. Because of increasing public concern over the ethical treatment of animals in research, we felt it incumbent upon us to include this general preface to these volumes in order to indicate why we think further - search using animals is necessary and why animal models of psychiatric disorders, in particular, are so important. We recognize that animals should only be used when suitable alternatives are not available. We think it self-e- dent, however, that humans can only be experimented upon in severely proscribed circumstances and alternative pro- dures using cell or tissue culture are inadequate in any models requiring assessments of behavioral change or of complex in vivo processes. However, when the distress, discomfort, or pain to the animals outweighs the anticipated gains for human welfare, then the research is not ethical and should not be carried out. It is imperative that each individual researcher examine his/her own research from a critical moral standpoint - fore engaging in it, taking into consideration the animals’ welfare as well as the anticipated gains. Furthermore, once a decision to proceed with research is made, it is the researcher’s responsibility to ensure that the animals’ w- fare is of prime concern in terms of appropriate housing, feeding, and maximum reduction of any uncomfortable or distressing effects of the experimental conditions, and that these conditions undergo frequent formalized monitoring.

Cellular and Animal Models in Human Genomics Research

Cellular and Animal Models in Human Genomics Research
Author: Anonim
Publsiher: Academic Press
Total Pages: 226
Release: 2019-07-30
ISBN 10: 012816574X
ISBN 13: 9780128165744
Language: EN, FR, DE, ES & NL

Cellular and Animal Models in Human Genomics Research Book Review:

Cellular and Animal Models in Human Genomics Research provides an indispensable resource for applying comparative genomics in the annotation of disease-gene associated variants that are identified by human genomic sequencing. The book presents a thorough overview of effective protocols for the use of cellular and animal modeling methods to turn lists of plausible genes into causative biomarkers. With chapters written by international experts, the book first addresses the fundamental aspects of using cellular and animal models in genetic and genomic studies, including in-depth examples of specific models and their utility, i.e., yeast, worms, flies, fish, mice and large animals. Protocols for properly conducting model studies, genomic technology, modeling candidate genes vs. genetic variants, integrative modeling, utilizing induced pluripotent stem cells, and employing CRISPR-Cas9 are also discussed in-depth. Provides a thorough, accessible resource that helps researchers and students employ cellular and animal models in their own genetic and genomic studies Offers guidance on how to effectively interpret the results and significance of genetic and genomic model studies for human health Features chapters from international experts in the use of specific cellular and animal models, including yeast, worms, flies, fish, mice, and large animals, among other organisms

Endophenotypes Of Psychiatric And Neurodegenerative Disorders In Rodent Models

Endophenotypes Of Psychiatric And Neurodegenerative Disorders In Rodent Models
Author: Sylvie Granon
Publsiher: Unknown
Total Pages: 358
Release: 2009-01-01
ISBN 10: 9788178954028
ISBN 13: 8178954028
Language: EN, FR, DE, ES & NL

Endophenotypes Of Psychiatric And Neurodegenerative Disorders In Rodent Models Book Review:

Psychiatric disorders are uniquely human. Yet we need animal models to test hypotheses about biological mechanisms. Treatment development relies on model systems to evaluate the efficacy of therapeutics. How can such a profound paradox be resolved? Dr. Sylvie Granon of the Institute Pasteur in Paris has successfully assembled a collection of fifteen review chapters that address multiple aspects of rodent models of neuropsychiatric disorders. Outstanding experts describe paradigms relevant to Alzheimer s disease, mental retardation, schizophrenia, autism, attentional deficit hyperactivity disorder, impulsivity, drug addiction, post-traumatic stress disorder, multiple sclerosis, and sudden infant death syndrome. Traditional lesioning and pharmacological methods are contrasted with newer targeted gene mutation strategies for generating rodent models. Strengths and limitations of transgenic and knockout mouse models are discussed by many of the insightful authors. In Alice in Wonderland, the Cheshire Cat speaks English and tell us We re all mad here. Unfortunately, real animals do not talk, and cannot tell us about their abnormal internal emotional or mental states, if any. It is essential to recognize that researchers will never be able to replicate schizophrenia or autism or depression in a mouse. Many psychiatric dysfunctions appear to originate primarily in the human frontal cerebral cortex, a highly developed structure that dramatically eclipses the modest frontal cortex of rodents. Numbers of synapses and available pathways for making neural connections that permit higher executive functions are enormously greater in humans as compared to other species. Expansion of the human prefrontal cortex is an evolutionary recent phenomenon. There has not been enough time for thorough trouble-shooting and beta-testing of its neural circuitry. No wonder so much can go so wrong. Endophenotypes offer a neat solution to our conundrum. Rather than trying to replicate the full human syndrome, specific components of behavioral symptoms and neuroanatomical abnormalities can be modeled in rodents. While mental illnesses that are primarily caused by incorrect developmental neuroanatomy or aberrant neurotransmitter pharmacology in the prefrontal cortex may be difficult to model in mice, whose prefrontal cortex is minimal, connections between frontal cortex and other brain regions such as thalamus are similar across species. Homologies between rodents and primates in frontal cortex connections and specific behavioral functions have been extensively described by Bryan Kolb. The inability of Alzheimer s patients to store new memories represents a discrete characteristic that can be paralleled in rats and mice, who store new memories using similar neurophysiological mechanisms. Schizophrenic patients display deficits in sensorimotor gating and errors in working memory. Very similar procedures and equipment are available to assay prepulse inhibition and working memory in humans, monkeys, rats, and mice. Neuropharmacological pathways mediating the biological actions of abused drugs are similar in humans and rats. Drug addicts show poor impulse control and poor decision making in tasks that are analogous to some forms of errors in the five choice serial reaction time task for rats and mice. Genetic mutations that produce synaptic dysfunctions or amyloid plaques in the human brain are inserted into the mouse genome to create mouse models of mental retardation, which are then evaluated on learning and memory tasks. Thus, a simpler focus on individual endophenotype components of a human disease permits reasonable analogies to be generated in model organisms. The ideal animal model of a human syndrome is quantitative, readily replicated across laboratories, and incorporates three types of validity. Face validity is the conceptual analogy to a human symptom or endophenotype. Some unusual social behaviors in mice offer a conceptual analogy to the first diagnostic symptom of autism, abnormal reciprocal social interactions. Construct validity employs the same cause or precipitating event in the animal model and the human disease. Inflammatory demyelination presents construct validity for a rodent model of multiple sclerosis. Predictive validity confirms the specific therapeutic response. Treatments that work in the human disease also work in the animal model. For example, antidepressants that are effective in treating post-traumatic stress disorder should effectively reverse the behavioral traits of a rat model of this syndrome. Very few animal models of neuropsychiatric diseases incorporate all three types of validity. The authors contributing to this volume explain the challenges, failures and successes of an impressively wide range of model organisms. As the true causes of mental illnesses are identified, neuroscientists and pharmaceutical researchers will design more targeted model systems with true construct validity to the etiologies of neuropsychiatric syndromes. Behavioral assays will continue to be invented and refined to optimize face validity to the endophenotypes of the human disease. Ultimately these endeavors will result in model organisms with high predictive validity and translational value, to enhance the discovery of effective cures for debilitating major mental illnesses.

Animal Models for Psychiatry

Animal Models for Psychiatry
Author: J. D. Keehn
Publsiher: Routledge
Total Pages: 262
Release: 2018-02-19
ISBN 10: 135136278X
ISBN 13: 9781351362788
Language: EN, FR, DE, ES & NL

Animal Models for Psychiatry Book Review:

Originally published in 1986, in this work Professor Keehn assesses the contributions of experimental psychology and ethology to psychiatric theory and practice at the time. He discusses the status of animals in psychopathology, and describes a number of animal clinical pictures, covering both abnormal movements and convulsions, and spontaneous behavioural disorders. He also includes animal models of such psychiatric illnesses as neurosis, psychosis, drug addiction and disorders of childhood, and examines the nature of mental illness and the status of psychiatric diagnosis. The book includes an evaluation of the ethics of experimental research with animals and a summary of humane experimental procedures. Animal Models for Psychiatry will be of special interest to psychiatrists, clinical and physiological psychologists, behavioural pharmacologists, and to veterinarians.

Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research

Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research
Author: National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Guidelines for the Use of Animals in Neuroscience and Behavioral Research
Publsiher: National Academies Press
Total Pages: 223
Release: 2003-08-22
ISBN 10: 9780309167857
ISBN 13: 030916785X
Language: EN, FR, DE, ES & NL

Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research Book Review:

Expanding on the National Research Council’s Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal’s well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.

Use of Laboratory Animals in Biomedical and Behavioral Research

Use of Laboratory Animals in Biomedical and Behavioral Research
Author: National Research Council,Institute of Medicine,Institute for Laboratory Animal Research,Commission on Life Sciences,Committee on the Use of Laboratory Animals in Biomedical and Behavioral Research
Publsiher: National Academies Press
Total Pages: 112
Release: 1988-02-01
ISBN 10: 0309038391
ISBN 13: 9780309038393
Language: EN, FR, DE, ES & NL

Use of Laboratory Animals in Biomedical and Behavioral Research Book Review:

Scientific experiments using animals have contributed significantly to the improvement of human health. Animal experiments were crucial to the conquest of polio, for example, and they will undoubtedly be one of the keystones in AIDS research. However, some persons believe that the cost to the animals is often high. Authored by a committee of experts from various fields, this book discusses the benefits that have resulted from animal research, the scope of animal research today, the concerns of advocates of animal welfare, and the prospects for finding alternatives to animal use. The authors conclude with specific recommendations for more consistent government action.

Cognitive deficits in schizophrenia and other neuropsychiatric disorders Convergence of preclinical and clinical evidence

Cognitive deficits in schizophrenia and other neuropsychiatric disorders  Convergence of preclinical and clinical evidence
Author: Ales Stuchlik,Tomiki Sumiyoshi
Publsiher: Frontiers Media SA
Total Pages: 329
Release: 2015-10-23
ISBN 10: 2889196798
ISBN 13: 9782889196791
Language: EN, FR, DE, ES & NL

Cognitive deficits in schizophrenia and other neuropsychiatric disorders Convergence of preclinical and clinical evidence Book Review:

Neuropsychiatric diseases, such as schizophrenia, Alzheimer's disease, and etc., represent a serious medical and socioeconomic problems. These diseases are often accompanied by impairments of cognitive function, e.g., abstract thinking, decision-making, attention, and several types of memory. Such deficits significantly disrupt quality of life and daily functioning of patients. Cognitive deficits in neuropsychiatric diseases are associated with alterations of brain morphology and function, and are often resistant to therapeutic interventions. In schizophrenia and related disorders, cognitive deficits are also defined as endophenotypes, i.e. measurable phenotypes linking these disaeses with discrete heritable and reproducible traits. This points to the importance of elucidating these endophenotypes in translational studies. Animal models may not mimic the full spectrum of clinical symptoms, but may act as analogies of particular behaviors or other pathological outcomes. They are useful to search for the etiology of particular psychiatric illnesses and novel therapeutics. Moreover, several behavioral tests to measure cognitive performance in rodents and other species have been implemented. The primary focus of the present topic is to provide up-to-date information on cognitive deficits of neuropsychiatric disorders, such as schizophrenia. This Research Topic also delineates future directions for translational studies aimed at developing novel treatments/interventions of cognitive disturbances.

Autoimmune Disease Models

Autoimmune Disease Models
Author: Irun R. Cohen,Ariel Miller
Publsiher: Academic Press
Total Pages: 329
Release: 2014-06-28
ISBN 10: 0080917364
ISBN 13: 9780080917368
Language: EN, FR, DE, ES & NL

Autoimmune Disease Models Book Review:

Because autoimmune disorders can wreak havoc in both humans and animals, these disorders are now the objects of intense and focused research. This book details specific animal models for a variety of autoimmune disorders. The contributors are recognized authorities who deal with the panoply of experimentally induced autoimmune disorders, including encephalomyelitis, allergic neuritis, uveoretinitis, myocarditis, and hepatitis. Also included are discussions of spontaneously appearing diseases such as autoimmune thyroiditis and systemic lupus erythematosus. Many other disorders are also covered in this comprehensive guide. Certain to be an aid in the planning of individual experiments and broader research programs, this book will be a valuable addition to the library of all practicing immunologists interested in immune system function and dysfunction.

Therapy and the Neural Network Model

Therapy and the Neural Network Model
Author: Theodore Wasserman,Lori Drucker Wasserman
Publsiher: Springer Nature
Total Pages: 200
Release: 2019-10-16
ISBN 10: 3030269213
ISBN 13: 9783030269210
Language: EN, FR, DE, ES & NL

Therapy and the Neural Network Model Book Review:

This innovative work explores integrating emerging research into how the brain processes information in applied therapeutic interventions. Typically, clinicians select therapeutic interventions based on their own training, personal experience or preference. This book aims to provide a new model, based upon the neural networks, to both understand the development of mental health issues and their persistence, and how and why to apply therapeutic interventions to impact the systems which are maintaining them. This work begins with a short and accessible overview of the neural network model, and the general aims of therapy. It elucidates components of the neural network model of learning such as reward recognition, automaticity, and memory reconsolidation, and how they apply to both general learning and new learning through the process in therapy. Next, the authors explore how the neural network model can be integrated across existing systems of therapy, including Cognitive Behavior therapy (CBT), Dialectical Behavior Therapy (DBT), third wave therapies and analytic therapies. Therapy and the Neural Network Model is an exciting resource for researchers and practitioners interested in understanding more about the applications of a neural network model for therapy and the how and why of building new mentally healthy cognitions, behaviors and emotions. Therapy and the Neural Network Model is also an essential theoretical foundation for both researchers and practitioners who wish to base their therapeutic practice on neuroscience and integrate their work with related fields such as behavioral medicine, health psychology, social work and public health.

Animal Models of Neurological Disease Neurodegenerative disease

Animal Models of Neurological Disease  Neurodegenerative disease
Author: Alan A. Boulton,Glen B. Baker,Roger F. Butterworth
Publsiher: Unknown
Total Pages: 329
Release: 1992
ISBN 10:
ISBN 13: LCCN:91035401
Language: EN, FR, DE, ES & NL

Animal Models of Neurological Disease Neurodegenerative disease Book Review:

Animal and Translational Models for CNS Drug Discovery Neurological disorders

Animal and Translational Models for CNS Drug Discovery  Neurological disorders
Author: Robert A. McArthur,Franco Borsini
Publsiher: Unknown
Total Pages: 329
Release: 2008
ISBN 10:
ISBN 13: OCLC:229026149
Language: EN, FR, DE, ES & NL

Animal and Translational Models for CNS Drug Discovery Neurological disorders Book Review:

Animal Models of Neurological Disease II

Animal Models of Neurological Disease  II
Author: Alan A. Boulton,Glen B. Baker,Roger F. Butterworth
Publsiher: Humana Press
Total Pages: 373
Release: 1992-07-29
ISBN 10: 9780896032118
ISBN 13: 0896032116
Language: EN, FR, DE, ES & NL

Animal Models of Neurological Disease II Book Review:

to the Animal Models Volumes This and several other volumes in the Neuromethods series will describe a number of animal models of neuropsychiatric disorders. Because of increasing public concern over the ethical treatment of animals in research, we felt it incumbent upon us to include this general preface to these volumes in order to indicate why we think further - search using animals is necessary and why animal models of psychiatric disorders, in particular, are so important. We recognize that animals should only be used when suitable alternatives are not available. We think it self-e- dent, however, that humans can only be experimented upon in severely proscribed circumstances and alternative pro- dures using cell or tissue culture are inadequate in any models requiring assessments of behavioral change or of complex in vivo processes. However, when the distress, discomfort, or pain to the animals outweighs the anticipated gains for human welfare, then the research is not ethical and should not be carried out. It is imperative that each individual researcher examine his/her own research from a critical moral standpoint - fore engaging in it, taking into consideration the animals’ welfare as well as the anticipated gains. Furthermore, once a decision to proceed with research is made, it is the researcher’s responsibility to ensure that the animals’ w- fare is of prime concern in terms of appropriate housing, feeding, and maximum reduction of any uncomfortable or distressing effects of the experimental conditions, and that these conditions undergo frequent formalized monitoring.