Mitochondrial Medicine

Mitochondrial Medicine
Author: Salvatore DiMauro,Michio Hirano,Eric A. Schon
Publsiher: CRC Press
Total Pages: 16
Release: 2019-11-29
ISBN 10: 9780367446369
ISBN 13: 0367446367
Language: EN, FR, DE, ES & NL

Mitochondrial Medicine Book Review:

Mitochondrial dysfunction is increasingly being recognized as the basis of a wide variety of human diseases. Providing an authoritative update on our current knowledge of mitochondrial medicine, this text draws together world authorities from various fields to present general therapeutic strategies, as well as the treatments presently available in different specialties - thus making it essential reading for clinicians involved with the management of patients with mitochondrial diseases. A unique work, this text covers a range of specialties, including cardiology, ophthalmology, otology, nephrology, gastroenterology, hematology-oncology, and reproductive medicine, and does not focus exclusively on the more commonly known neurologic conditions. An accessible, user-friendly text, it also presents translational concepts of mitochondrial biogenesis and genetics in vignettes related to specific questions raised by the disease under discussion, rather than concentrating on basic science, which can often intimidate clinicians. This pioneering work is primarily directed to a clinical audience who are interested in the diverse and diagnostically challenging clinical presentations of mitochondrial diseases and their pathophysiology.

Mitochondria in Health and in Sickness

Mitochondria in Health and in Sickness
Author: Andrea Urbani,Mohan Babu
Publsiher: Springer Nature
Total Pages: 277
Release: 2019-08-26
ISBN 10: 9811383677
ISBN 13: 9789811383670
Language: EN, FR, DE, ES & NL

Mitochondria in Health and in Sickness Book Review:

Besides bringing together researchers and clinicians from various disciplines to share their scope of research on the seminal role of mitochondria in human disease, this original volume of the book has a broader appeal by exploring the health and disease of mitochondria, with specific emphasis on how mitochondrial dysfunction contributes to the development of various neurodegeneration, cancer, and metabolic disorders. The book also provides a foundational overview of the mitochondrial pathogenic or genetic variants and highlights various analytical tools used in the field of mitochondrial genetics; mitochondrial replacement therapy and strategies geared towards shifting heteroplasmy in individuals with mitochondrial disease; how state-of-the-art omics technologies (proteomics, functional genomics) have been employed to study mitochondrial biology in healthy and disease states; post-translational modifications in the regulation of mitochondrial proteins; and the role of mitochondria in host-pathogen interactions. Current approaches taken to study steady-state characteristics of mitochondrial structure and function in live mammalian cells in the contexts of normal and diseased states, and most recent research efforts to develop compounds with anti-cancer potential by targeting mitochondrial proteases or advances in therapeutic approaches towards mitochondrial disease were also explored. By covering this broad range of topics, our hope is to disseminate a wealth of knowledge on the critical role of mitochondria, and how to probe its function in health and in sickness.

Mitochondrial Diseases

Mitochondrial Diseases
Author: Eylem Taskin,Celal Guven,Yusuf Sevgiler
Publsiher: BoD – Books on Demand
Total Pages: 496
Release: 2018-08-29
ISBN 10: 1789236746
ISBN 13: 9781789236743
Language: EN, FR, DE, ES & NL

Mitochondrial Diseases Book Review:

Mitochondria are crucial organelles for any cell type. Mitochondria take responsibility for not only energy production but also regulation of cell death, also called apoptosis; calcium storage; and heat production. Therefore, mitochondrial disease is implicated in the mode of action of many harmful factors for cells such as drugs and environmental contaminants, dysfunction of the oxygen transport system, malnutrition, intense exercise, and genetic variations. This book presents up-to-date knowledge about mitochondrial disease and its complex relation to some diseases such as cardiac failure, cancer, and Alzheimer's and Parkinson's diseases. This book will, therefore, be essential for readers who are interested in life sciences, especially in medicine.

Cancer as a Metabolic Disease

Cancer as a Metabolic Disease
Author: Thomas Seyfried
Publsiher: John Wiley & Sons
Total Pages: 438
Release: 2012-05-18
ISBN 10: 1118310306
ISBN 13: 9781118310304
Language: EN, FR, DE, ES & NL

Cancer as a Metabolic Disease Book Review:

The book addresses controversies related to the origins of cancerand provides solutions to cancer management and prevention. Itexpands upon Otto Warburg's well-known theory that all cancer is adisease of energy metabolism. However, Warburg did not linkhis theory to the "hallmarks of cancer" and thus his theory wasdiscredited. This book aims to provide evidence, throughcase studies, that cancer is primarily a metabolic diseaserequring metabolic solutions for its management andprevention. Support for this position is derived fromcritical assessment of current cancer theories. Brain cancercase studies are presented as a proof of principle for metabolicsolutions to disease management, but similarities are drawn toother types of cancer, including breast and colon, due tothe same cellular mutations that they demonstrate.

Mitochondria in Obesity and Type 2 Diabetes

Mitochondria in Obesity and Type 2 Diabetes
Author: Beatrice Morio,Luc Penicaud,Michel Rigoulet
Publsiher: Academic Press
Total Pages: 459
Release: 2019-04-13
ISBN 10: 0128118598
ISBN 13: 9780128118597
Language: EN, FR, DE, ES & NL

Mitochondria in Obesity and Type 2 Diabetes Book Review:

Mitochondria in Obesity and Type 2 Diabetes: Comprehensive Review on Mitochondrial Functioning and Involvement in Metabolic Diseases synthesizes discoveries from laboratories around the world, enhancing our understanding of the involvement of mitochondria in the etiology of diseases, such as obesity and type 2 diabetes. Chapters illustrate and provide an overview of key concepts on topics such as the role of mitochondria in adipose tissue, cancer, cardiovascular comorbidities, skeletal muscle, the liver, kidney, and more. This book is a must-have reference for students and educational teams in biology, physiology and medicine, and researchers. Synthesizes actual knowledge on mitochondrial function Provides an integrated vision of each tissue in the etiology of obesity and type 2 diabetes Identifies the interactive networks that involve alteration in mitochondrial mass and function in disease progression Highlights the role played by mitochondria in the prevention and treatment of obesity and type 2 diabetes

Mitochondrial Replacement Techniques

Mitochondrial Replacement Techniques
Author: National Academies of Sciences, Engineering, and Medicine,Institute of Medicine,Board on Health Sciences Policy,Committee on the Ethical and Social Policy Considerations of Novel Techniques for Prevention of Maternal Transmission of Mitochondrial DNA Diseases
Publsiher: National Academies Press
Total Pages: 200
Release: 2016-03-17
ISBN 10: 0309388732
ISBN 13: 9780309388733
Language: EN, FR, DE, ES & NL

Mitochondrial Replacement Techniques Book Review:

Mitochondrial replacement techniques (MRTs) are designed to prevent the transmission of mitochondrial DNA (mtDNA) diseases from mother to child. While MRTs, if effective, could satisfy a desire of women seeking to have a genetically related child without the risk of passing on mtDNA disease, the technique raises significant ethical and social issues. It would create offspring who have genetic material from two women, something never sanctioned in humans, and would create mitochondrial changes that could be heritable (in female offspring), and therefore passed on in perpetuity. The manipulation would be performed on eggs or embryos, would affect every cell of the resulting individual, and once carried out this genetic manipulation is not reversible. Mitochondrial Replacement Techniques considers the implications of manipulating mitochondrial content both in children born to women as a result of participating in these studies and in descendants of any female offspring. This study examines the ethical and social issues related to MRTs, outlines principles that would provide a framework and foundation for oversight of MRTs, and develops recommendations to inform the Food and Drug Administration's consideration of investigational new drug applications.

A Practical Approach to the Spectrum of Alcoholic Liver Disease, An Issue of Clinics in Liver Disease - E-Book

A Practical Approach to the Spectrum of Alcoholic Liver Disease, An Issue of Clinics in Liver Disease - E-Book
Author: David Bernstein
Publsiher: Elsevier Health Sciences
Total Pages: 240
Release: 2012-11-14
ISBN 10: 1455747378
ISBN 13: 9781455747375
Language: EN, FR, DE, ES & NL

A Practical Approach to the Spectrum of Alcoholic Liver Disease, An Issue of Clinics in Liver Disease - E-Book Book Review:

The Guest Editor has organized this issue to focus on the clinical management of alcoholic liver disease. Authors have written state-of-the-art reviews on the following topics: Prevalence and Natural History of ALD; Alcohol Metabolism; Immunology in ALD; Histological Findings in ALD; Diagnosis and Management of Alcoholic Hepatitis; Management of Alcohol Abuse; Long Term Management of Alcoholic Liver Disease; Infections in ALD; Nutrition in ALD; Alcohol’s Effect on Other Chronic Liver Diseases; Liver Cancer and Alcohol; Evaluation and Selection of Candidates for Liver Transplantation; and ALD and Specific Transplant-Related Issues.

Inborn Errors of Metabolism

Inborn Errors of Metabolism
Author: Brendan Lee MD, PhD,Fernando Scaglia MD
Publsiher: Oxford University Press
Total Pages: 400
Release: 2014-10-01
ISBN 10: 0199797684
ISBN 13: 9780199797684
Language: EN, FR, DE, ES & NL

Inborn Errors of Metabolism Book Review:

Texts on inborn errors of metabolism (IEMs) have traditionally focused on classical biochemistry, clinical presentation, and standard treatment approaches. Inborn Errors of Metabolism is an expansion on this model, one that establishes an innovative pathway approach and provides a new authority on this family of disease. Alongside the standard cadre of molecular and clinical underpinnings, this volume includes coverage of newborn screenings and an overarching treatment of IEMs as complex diseases -- how basic alterations can lead to complex secondary and tertiary effects in metabolism that contribute to increasingly recognized natural histories of disease.

A Practical Approach to Movement Disorders

A Practical Approach to Movement Disorders
Author: Michael S. Okun, MD,Ramon L. Rodriguez, MD,Frank M. Skidmore, MD
Publsiher: Demos Medical Publishing
Total Pages: 274
Release: 2007-06-14
ISBN 10: 1935281887
ISBN 13: 9781935281887
Language: EN, FR, DE, ES & NL

A Practical Approach to Movement Disorders Book Review:

This book provides the busy clinician with a quick, symptom-based guide to the clinical presentation, diagnosis, work-up, and management of the most common types of movement disorders encountered in clinical practice, including Parkinson's disease, chorea, dystonia, myoclonus, and ataxia. Written in expanded outline format, with frequent diagnostic and therapeutic algorithms, tables, and scales, it is an essential guide for clinicians faced with patients with movement disorders. A Practical Approach to Movement Disorders is a welcome departure from the typical lengthy, disease-based hardbound texts ill suited for the busy clinician. Practical yet authoritative, this fit-in-your-coat-pocket guide begins with a comprehensive description of the different presentations of movement disorders. It then details the medical, surgical, and non-pharmacological approaches, including speech and swallowing therapy and physical and occupational therapy. Key features include: Symptom-based, rather than disease-based, chapters A focus on the most common movement disorders A unique section on the neurological aspects of deep brain stimulation (DBS) Dozens of diagnostic and management pearls Suggested readings for each chapter Handy and comprehensive, A Practical Approach to Movement Disorders is the only guide for busy clinicians needing quick information on movement disorders.

Mitochondrial Case Studies

Mitochondrial Case Studies
Author: Russell Saneto,Sumit Parikh,Bruce H Cohen
Publsiher: Academic Press
Total Pages: 338
Release: 2015-11-24
ISBN 10: 0128011491
ISBN 13: 9780128011492
Language: EN, FR, DE, ES & NL

Mitochondrial Case Studies Book Review:

Mitochondrial Case Studies: Underlying Mechanisms and Diagnosis offers the science behind mitochondrial disease with a case studies approach. Since mitochondrial diseases are diverse and influenced by genetic, environmental, and social-economic factors, this publication will help students, physicians, scientists, health care students, and families recognize and accurately diagnose mitochondrial disease and learn about potential treatments. Reviews case studies as a helpful teaching tool to increase awareness and improve diagnosis Provides information on underlying mechanisms of mitochondrial disease Includes basic mitochondrial dysfunction research through patient case studies to best illustrate the entire disease process

Mitochondrial Dysfunction

Mitochondrial Dysfunction
Author: Lawrence H. Lash,Dean P. Jones
Publsiher: Elsevier
Total Pages: 528
Release: 2013-10-22
ISBN 10: 1483218619
ISBN 13: 9781483218618
Language: EN, FR, DE, ES & NL

Mitochondrial Dysfunction Book Review:

Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.

Mitochondrial Medicine

Mitochondrial Medicine
Author: Anna Gvozdjáková
Publsiher: Springer Science & Business Media
Total Pages: 409
Release: 2008-02-01
ISBN 10: 9781402067143
ISBN 13: 1402067143
Language: EN, FR, DE, ES & NL

Mitochondrial Medicine Book Review:

Mitochondrial medicine deals with diseases that are related to mitochondrial dysfunction due to a number of causes from free radical damage to genetic mutation. This book is based on extensive data gathered over 30 years of clinical and experimental research. In it, internationally recognized authors share their experience in various fields of their expertise and guide readers through the disease process, from basic biochemical mechanisms to diagnosis to therapeutic aspects.

Genetics Diagnosis, Inborn Errors of Metabolism and Newborn Screening: An Update, An Issue of Clinics in Perinatology,

Genetics Diagnosis, Inborn Errors of Metabolism and Newborn Screening: An Update, An Issue of Clinics in Perinatology,
Author: Michael J. Gambello
Publsiher: Elsevier Health Sciences
Total Pages: 281
Release: 2015-08-12
ISBN 10: 0323356850
ISBN 13: 9780323356855
Language: EN, FR, DE, ES & NL

Genetics Diagnosis, Inborn Errors of Metabolism and Newborn Screening: An Update, An Issue of Clinics in Perinatology, Book Review:

Genetic testing and genome sequencing have opened up the possibility to clinicians and families to treat diseases, syndromes, and malformations earlier and provide therapeutic interventions.The guest editors seek to provide a basic overview of the topic for the neonatologist/perinatologist. Articles addres dysmorphology, syndromes in the infant, skeletal dysplasias, limb malformations, craniofacial anomolies, GI/liver disease, disorders of sexual develoment, brain defects, inborn errors of metabolism, and congenital heart disease.

Pediatric Primary Care - E-Book

Pediatric Primary Care - E-Book
Author: Catherine E. Burns,Ardys M. Dunn,Margaret A. Brady,Nancy Barber Starr,Catherine G. Blosser,Dawn Lee Garzon Maaks
Publsiher: Elsevier Health Sciences
Total Pages: 1288
Release: 2012-03-01
ISBN 10: 1455742171
ISBN 13: 9781455742172
Language: EN, FR, DE, ES & NL

Pediatric Primary Care - E-Book Book Review:

Covering the full spectrum of health conditions seen in the primary care of children, Pediatric Primary Care, 5th Edition emphasizes both prevention and management from the unique perspective of the Nurse Practitioner. Written by an expert editor/contributor team, it provides in-depth, evidence-based guidance for assessing and managing health problems in children from infancy through adolescence. Other key topics include developmental theory, the health status of children today, issues of daily living, and cultural considerations. Four-part organization includes an introductory unit, plus units on child development, the health management of children, and diseases and disorders common to childhood. UNIQUE! Functional health patterns framework in Unit Three provides a lens for discussing health promotion through the various components of healthy living. UNIQUE! ICD framework in Unit Four addresses the classification used to code diseases in both hospital and outpatient settings. UNIQUE! Practice management chapter provides need-to-know information on managing a private healthcare practice, including issues of productivity, compliance with applicable laws, quality-of-care indicators, and successful business practices. UNIQUE! Environmental health chapter offers evidence-based content on the effects of environmental toxicants, such as tobacco smoke, heavy metals, and air pollutants. An 8-page color insert presents over 40 photos that visually demonstrate key assessment findings for ear, skin, and other conditions. NEW! Pediatric Pain Management chapter addresses the increased recognition of pain as the "fifth vital sign" with expanded coverage of acute and chronic pain management in children. Extensively revised and updated genetics chapter presents a new paradigm for addressing genetic considerations in clinical practice, including an introduction to epigenetics. Increased emphasis on health disparities explores the growing health disparities among children in the U.S and worldwide and provides strategies to help patients and parents gain accessibility to health care resources. NEW! Content on implementing a "medical home" explores the trend toward family-centered coordinated health care and fosters appropriate treatment for children with chronic disease. NEW! Updated coverage takes a more global approach, exploring the health status of children outside the U.S. Expanded imaging content offers valuable guidance on using various imaging modalities, including how to prepare the child for diagnostics.

Update on Dementia

Update on Dementia
Author: Davide Moretti
Publsiher: BoD – Books on Demand
Total Pages: 558
Release: 2016-09-28
ISBN 10: 9535126547
ISBN 13: 9789535126546
Language: EN, FR, DE, ES & NL

Update on Dementia Book Review:

The dementia challenge is the largest health effort of the times we live in. The whole society has to move to a realization of the significance of prioritization to make an attempt in the direction of mental health promotion and dementia risk reduction. New priorities for research are needed to go far beyond the usual goal of constructing a disease course-modifying medication. Moreover, a full empowerment and engagement of men and women living with dementia and their caregivers, overcoming stigma and discrimination should be promoted. The common efforts and the final aim will have to be the progress of a ''dementia-constructive'' world, where people with dementia can take advantage of equal opportunities.

Inherited Metabolic Diseases

Inherited Metabolic Diseases
Author: Georg F. Hoffmann,Johannes Zschocke,William L. Nyhan
Publsiher: Springer
Total Pages: 605
Release: 2016-09-20
ISBN 10: 3662494108
ISBN 13: 9783662494103
Language: EN, FR, DE, ES & NL

Inherited Metabolic Diseases Book Review:

This book focuses on clinical presentations that may be caused by inherited metabolic diseases. Its symptom- and system-based approach will help clinicians with and without detailed knowledge of human biochemistry in all specialties to reach a correct diagnosis and institute the optimal treatment program. The book summarizes the central elements of inherited metabolic diseases and describes clearly how to carry out an efficient yet complete diagnostic work-up, thereby guiding the clinician from the presenting symptoms and signs through to effective initial management. After an introduction to the different disorders, the book explains when to consider an inborn metabolic error and which initial tests to order. Core aspects such as structured communication, guidelines, transition, pregnancy, maternal care and how to respond to various medical emergencies are covered. Therapeutic concepts such as dietary treatment are delineated and practical advice provided on the quite different treatment approaches required for individual diseases. An extensive section structured according to organ systems outlines the correct approach in the context of specific symptoms and signs. The value of each of the potential investigations is explained, with precise advice on the interpretation of results. The inclusion of algorithms, tables, lists, and charts facilitates rapid decision making and information retrieval, and the appendices include a helpful guide to differential diagnosis based on clinical and biochemical phenotypes. This new updated edition of Inherited Metabolic Diseases will be an invaluable aid for the busy clinician and an excellent quick reference for metabolic and genetic specialists.

Metabolic Diseases

Metabolic Diseases
Author: E. Gilbert-Barness,L.A. Barness,P.M. Farrell
Publsiher: IOS Press
Total Pages: 960
Release: 2017-01-06
ISBN 10: 1614997187
ISBN 13: 9781614997184
Language: EN, FR, DE, ES & NL

Metabolic Diseases Book Review:

The 2nd Edition of Metabolic Diseases provides readers with a completely updated description of the Foundations of Clinical Management, Genetics, and Pathology. A distinguished group of 31 expert authors has contributed 25 chapters as a tribute to Enid Gilbert-Barness and the late Lewis Barness--- both pioneers in this topic. Enid’s unique perspectives on the pathology of genetic disorders and Lew’s unsurpassed knowledge of metabolism integrated with nutrition have inspired the contributors to write interdisciplinary descriptions of generally rare, and always challenging, hereditary metabolic disorders. Discussions of these interesting genetic disorders are organized in the perspective of molecular abnormalities leading to morphologic disturbances with distinct pathology and clinical manifestations. The book emphasizes recent advances such as development of improved diagnostic methods and discovery of new, more effective therapies for many of the diseases. It includes optimal strategies for diagnosis and information on access to specialized laboratories for specific testing. The target audience is a wide variety of clinicians, including pediatricians, neonatologists, obstetricians, maternal-fetal specialists, internists, pathologists, geneticists, and laboratorians engaged in prenatal and/or neonatal screening. In addition, all scientists and health science professionals interested in metabolic diseases will find the comprehensive, integrated chapters informative on the latest discoveries. It is our hope that the 2nd Edition will open new avenues and vistas for our readers and that they will share with us the interest, excitement and passion of the research into all these challenging disorders.

Mitochondria in Liver Disease

Mitochondria in Liver Disease
Author: Derick Han,Neil Kaplowitz
Publsiher: CRC Press
Total Pages: 485
Release: 2015-10-28
ISBN 10: 1482236982
ISBN 13: 9781482236989
Language: EN, FR, DE, ES & NL

Mitochondria in Liver Disease Book Review:

"...excellent, well-organized, and timely." —Lester Packer and Enrique Cardenas, University of Southern California, Los Angeles, from the Series Preface The liver is a vital organ that is responsible for a wide range of functions, most of which are essential for survival. The multitude of functions the liver performs makes it vulnerable to a wide range of diseases. Mitochondrial dysfunction plays an important role in many liver diseases including drug-induced liver injury, alcoholic liver disease, and nonalcoholic fatty liver disease. Mitochondria in Liver Disease gathers the most current research regarding the role of mitochondria in the liver and various diseases to which it is susceptible. The book is separated into two sections, the first of which highlights the latest developments in mitochondrial research. It includes cutting-edge topics such as the regulation of mitochondrial respiration using hydrogen sulfide and the regulation of mitochondrial fusion–fission via the endoplasmic reticulum. The second section reviews the most current research on the role of mitochondria in a wide range of liver diseases. It also addresses novel topics such as the importance of liver mitochondrial constituents as biomarkers of liver injury in plasma and as regulators of the immune system. Mitochondria in Liver Disease represents the current state of knowledge and research on mitochondrial roles in liver diseases. Written by a group of global experts, it provides an authoritative and comprehensive overview of the latest advances and methods that mark key starting points for future research.

Mitochondrial DNA

Mitochondrial DNA
Author: Herve Seligmann,Ganesh Warthi
Publsiher: BoD – Books on Demand
Total Pages: 224
Release: 2018-10-31
ISBN 10: 1789842654
ISBN 13: 9781789842654
Language: EN, FR, DE, ES & NL

Mitochondrial DNA Book Review:

The very short genomes of mitochondria summarize the complexity of molecular biology and its interactions with cellular and whole organism biology. Studies of mitogenomes contribute to the understanding of molecular biology and evolution, and to health management. Despite or even due to their small sizes, mitogenomes continue to surprise us. Studies of mitogenomes reveal the details of molecular organization and its evolution under constraints for miniaturization.

Mitochondrial Mechanisms of Degeneration and Repair in Parkinson's Disease

Mitochondrial Mechanisms of Degeneration and Repair in Parkinson's Disease
Author: Lori M. Buhlman
Publsiher: Springer
Total Pages: 275
Release: 2016-09-13
ISBN 10: 3319421395
ISBN 13: 9783319421391
Language: EN, FR, DE, ES & NL

Mitochondrial Mechanisms of Degeneration and Repair in Parkinson's Disease Book Review:

This volume brings together various theories of how aberrations in mitochondrial function and morphology contribute to neurodegeneration in idiopathic and familial forms of Parkinson’s disease. Moreover, it comprehensively reviews the current search for therapies, and proposes how molecules are involved in specific functions as attractive therapeutic targets. It is expected to facilitate critical thought and discussion about the fundamental aspects of neurodegeneration in Parkinson’s disease and foster the development of therapeutic strategies among researchers and graduate students. Theories of idiopathic Parkinson’s etiology support roles for chronic inflammation and exposure to heavy metals or pesticides. Interestingly, as this project proposes, a case can be made that abnormalities in mitochondrial morphology and function are at the core of each of these theories. In fact, the most common approach to the generation of animal and cell-culture models of idiopathic Parkinson’s disease involves exposure to mitochondrial toxins. Even more compelling is the fact that most familial patients harbor genetic mutations that cause disruptions in normal mitochondrial morphology and function. While there remains to be no effective treatment for Parkinson’s disease, efforts to postpone, prevent and “cure” onset mitochondrial aberrations and neurodegeneration associated with Parkinson’s disease in various models are encouraging. While only about ten percent of Parkinson’s patients inherit disease-causing mutations, discovering common mechanisms by which familial forms of Parkinson’s disease manifest will likely shed light on the pathophysiology of the more common idiopathic form and provide insight to the general process of neurodegeneration, thus revealing therapeutic targets that will become more and more accessible as technology improves.