Mitochondria in Neurological Disorders

Mitochondria in Neurological Disorders
Author: Rajat Sandhir
Publsiher: Academic Press
Total Pages: 500
Release: 2022-06-15
ISBN 10: 9780128217313
ISBN 13: 0128217316
Language: EN, FR, DE, ES & NL

Mitochondria in Neurological Disorders Book Review:

Mitochondria in Neurological Diseases highlights various therapeutic approaches targeting mitochondria in neurological conditions. Focused on diverse neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, depression, and Amyotrophic lateral sclerosis, topics span basic mitochondrial physiology to mitochondrial dynamics and to the altered states of the nervous system. This book is appropriate for anyone interested in learning more about the physiological and pathophysiological functions of mitochondria in the nervous system. Provides up-to-date information on role of mitochondria in nervous system for graduate students and researchers Presents chapters on energy substrate utilization, calcium handling, mitochondria-organelle communication, and cell signaling Discusses recent techniques in understanding mitochondrial functions in the nervous system Emphasizes the role of altered mitochondrial functions in various neurological conditions and their potential treatment strategies for targeting mitochondria Includes chapter references (key articles, books, protocols) for additional detailed study

Mitochondrial Disorders in Neurology

Mitochondrial Disorders in Neurology
Author: Anthony H.V. Schapira,S. Dimauro
Publsiher: Butterworth-Heinemann
Total Pages: 264
Release: 2013-10-22
ISBN 10: 1483193691
ISBN 13: 9781483193694
Language: EN, FR, DE, ES & NL

Mitochondrial Disorders in Neurology Book Review:

Mitochondrial Disorders in Neurology provides an overview of mitochondrial diseases. This book discusses the effects of mitochondrial dysfunction based on the relevant biochemistry and molecular genetics. The abnormal muscle and mitochondrial morphology in a variety of clinical presentations from isolated ophthalmoplegia to severe encephalopathy are also elaborated. This text likewise deliberates Leber's hereditary optic neuropathy, neurodegenerative disorders, and respiratory chain defects. Other topics covered include mitochondrial DNA and the genetics of mitochondrial disease; cytochrome oxidase deficiency; use of tissue culture in the diagnosis of mitochondrial disease; and advances in mitochondrial genetics. This publication is a good source for clinicians and students concerned with the defective mitochondrial function.

Mitochondria and Brain Disorders

Mitochondria and Brain Disorders
Author: Stavros Baloyannis
Publsiher: BoD – Books on Demand
Total Pages: 124
Release: 2020-03-11
ISBN 10: 1789855314
ISBN 13: 9781789855319
Language: EN, FR, DE, ES & NL

Mitochondria and Brain Disorders Book Review:

The mitochondrion is a unique and ubiquitous organelle that contains its own genome, encoding essential proteins that are major components of the respiratory chain and energy production system. Mitochondria play a dominant role in the life and function of eukaryotic cells including neurons and glia, as their survival and activity depend upon mitochondrial energy production and supply. Besides energy production, mitochondria also play a vital role in calcium homeostasis and may induce apoptosis by excitotoxicity. Mitochondrial dysfunction is related to common neurological diseases, such as Parkinson's disease, Alzheimer's disease, Friedreich's ataxia, Huntington's disease, and Multiple Sclerosis. An efficient treatment of mitochondrial dysfunction would open new horizons in the therapeutic perspectives of a substantial number of inflammatory and degenerative neurological disorders.

Mitochondria and Brain Disorders

Mitochondria and Brain Disorders
Author: Stavros J. Baloyannis
Publsiher: Unknown
Total Pages: 135
Release: 2020
ISBN 10: 9781789855326
ISBN 13: 1789855322
Language: EN, FR, DE, ES & NL

Mitochondria and Brain Disorders Book Review:

Mitochondrial Dysfunction in Neurodegenerative Disorders

Mitochondrial Dysfunction in Neurodegenerative Disorders
Author: Amy Katherine Reeve,Kim Jennifer Krishnan,Michael R. Duchen,Doug M Turnbull
Publsiher: Springer Science & Business Media
Total Pages: 242
Release: 2011-11-15
ISBN 10: 9780857297013
ISBN 13: 0857297015
Language: EN, FR, DE, ES & NL

Mitochondrial Dysfunction in Neurodegenerative Disorders Book Review:

As age related diseases increase in prevalence and impact more significantly on medical resources it is imperative to understand these diseases and the mechanisms behind their progression. New research has stimulated a growing interest in mitochondrial involvement in neurodegenerative disorders such as Parkinson’s disease, Alzheimer’s disease and multiple sclerosis and the mechanisms which lead from mitochondrial dysfunction to neurodegeneration. Mitochondrial Dysfunction in Neurodegenerative Disorders brings together contributions from leaders in the field internationally on the various ways in which mitochondrial dysfunction contributes to the pathogenesis of these diseases, guiding the reader through the basic functions of mitochondria and the mechanisms that lead to their dysfunction, to the consequences of this dysfunction on neuronal function before finishing with the modelling of these disorders and discussion of new potential therapeutic targets. Mitochondrial Dysfunction in Neurodegenerative Disorders provides an accessible, authoritative guide to this important area for neurologists; research and clinical neuroscientists; neuropathologists; and residents with an interest in clinical research.

Mitochondria in Health and Disease

Mitochondria in Health and Disease
Author: Carolyn D. Berdanier
Publsiher: CRC Press
Total Pages: 640
Release: 2005-06-09
ISBN 10: 1420028847
ISBN 13: 9781420028843
Language: EN, FR, DE, ES & NL

Mitochondria in Health and Disease Book Review:

It was once assumed that mitochondrial diseases were rare and that few people were affected. As knowledge has grown about these organelles and their function, it became clear that mitochondrial malfunction could be linked to several chronic diseases. Diabetes has been associated with DNA mutation and can cause mutation itself. This text discusses findings involving the effects of disease on mitochondrial number, mitogenesis, and the base sequence of mitochondrial DNA. Experts discuss their study of mitochondria and what happens when it malfunctions. This book also explores the idea that mutated mitochondrial DNA can result in disease, and vice versa.

Mitochondrial Medicine

Mitochondrial Medicine
Author: Salvatore DiMauro,Michio Hirano,Eric A. Schon
Publsiher: CRC Press
Total Pages: 135
Release: 2019-11-26
ISBN 10: 9780367446369
ISBN 13: 0367446367
Language: EN, FR, DE, ES & NL

Mitochondrial Medicine Book Review:

Mitochondrial dysfunction is increasingly being recognized as the basis of a wide variety of human diseases. Providing an authoritative update on our current knowledge of mitochondrial medicine, this text draws together world authorities from various fields to present general therapeutic strategies, as well as the treatments presently available in different specialties - thus making it essential reading for clinicians involved with the management of patients with mitochondrial diseases. A unique work, this text covers a range of specialties, including cardiology, ophthalmology, otology, nephrology, gastroenterology, hematology-oncology, and reproductive medicine, and does not focus exclusively on the more commonly known neurologic conditions. An accessible, user-friendly text, it also presents translational concepts of mitochondrial biogenesis and genetics in vignettes related to specific questions raised by the disease under discussion, rather than concentrating on basic science, which can often intimidate clinicians. This pioneering work is primarily directed to a clinical audience who are interested in the diverse and diagnostically challenging clinical presentations of mitochondrial diseases and their pathophysiology.

Mitochondria dependent Local Caspase Activation and Mitofusin 2 mediated Mitophagy in Neurodegeneration

Mitochondria dependent Local Caspase Activation and Mitofusin 2 mediated Mitophagy in Neurodegeneration
Author: Hao Chen
Publsiher: Unknown
Total Pages: 135
Release: 2020
ISBN 10: 1928374650XXX
ISBN 13: OCLC:1233703256
Language: EN, FR, DE, ES & NL

Mitochondria dependent Local Caspase Activation and Mitofusin 2 mediated Mitophagy in Neurodegeneration Book Review:

Mitochondria are critical regulators of neuronal physiology. They play a pivotal role in energy supply and Ca2+ buffering. Thus, mitochondria can sustain the synapse and neuronal function. In this regard, the mitochondria with an impaired capacity of bioenergetics or Ca2+ buffering will lead to synapse failure and neurodegeneration. Moreover, emerging evidence has shown that damaged mitochondria are also involved in local caspase activation, which coincides with spine pruning and neurodegeneration. However, the impacts of local caspase signaling on spine dynamics and neurodegeneration are still not clarified. To clarify them is critical for neurological disorders, in which the mitochondrial deficits are prominent and hard to be fixed. Additionally, as a pivotal mitochondrial enzyme – the F1Fo ATP synthase, dysfunction of it will lead to diseases with spinopathy. To this end, we inhibited the F1Fo ATP synthase by applying the sublethal oligomycin A to primary cultured neurons. Then, it induced the mitochondrial dysfunction and local caspase signaling. Following this, we blocked the caspase signaling through its inhibitor to determine whether it can rescue the spine elimination. In this case, we can dissect the caspase signaling out of mitochondrial energy supply and examine how much the caspase signaling attributes to spine pruning. Furthermore, we will find new ways to prevent the senescence of neurons through caspase inhibition. Moreover, mitochondrial quality control is of paramount importance for neuronal survival. Notably, mitophagy is a vital mechanism for maintenance of mitochondrial quality control. A previous study has shown that Mitofusin2 (Mfn2) plays a key role in mediating mitophagy in cardiomyocytes, which was demonstrated by decreased mitophagy in Mfn2 knockdown cardiomyocytes. In addition, lowered expression levels of Mfn2 have been repeatedly found in many neurodegenerative diseases like Alzheimer’s disease, which is characterized by the accumulation of damaged mitochondrial and mitophagosomes in neurons. In this regard, reduced Mfn2 expression may lead to compromised mitophagy and mitochondrial quality control. However, whether Mfn2 is indispensable for facilitating mitophagy has not been fully investigated. To this end, we knocked down Mfn2 in primary cultured neurons. Then, we examined the state of mitophagy. Intriguingly, we observed more mitophagosomes formation in Mfn2 knock-down neurons. It indicates the Mfn2 is not necessary for mitophagy induction. Such discrepancy may arise from the heterogeneity of different cell types. Also, it may arise from some alternative adaptor proteins, which can activate mitophagy. From previous reports, people pulled down the conjugated proteins from the outer mitochondrial membrane (OMM) of senescent and healthy neurons. After screening them by mass spectrum, they found that several OMM proteins may be the potential receptors for mitophagosome formation. Among them, Voltage-Dependent Anion Channel (VDAC) is the one most reported for mitophagy induction. Accordingly, we will further knockdown VDAC in Mfn2 knock-down neurons and examine the mitophagy states. In this case, we can determine whether VDAC can work as an Mfn2-independent alternative trigger for mitophagy in neurons. In all, both local caspases signaling and mitophagy play essential roles in neurodegeneration. Regulation of them may provide us new avenues for treating neurodegenerative diseases..

Mitochondrial Dysfunction in Neurodegenerative Disorders

Mitochondrial Dysfunction in Neurodegenerative Disorders
Author: Amy K. Reeve,Eve M. Simcox,Michael R. Duchen,Doug M. Turnbull
Publsiher: Springer
Total Pages: 380
Release: 2016-06-08
ISBN 10: 3319286374
ISBN 13: 9783319286372
Language: EN, FR, DE, ES & NL

Mitochondrial Dysfunction in Neurodegenerative Disorders Book Review:

This second edition brings together up-to-date contributions from leaders in the field internationally on the various ways in which mitochondrial dysfunction contributes to the pathogenesis of neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease and multiple sclerosis. The reader is guided through the basic functions of mitochondria and the mechanisms that lead to their dysfunction, and on to the consequences of this dysfunction for neuronal function before finishing with the modelling of these disorders and discussion of new potential therapeutic targets. Additional chapters have been added to the book to reflect advances in the field and there are many new contributors and topics, including how mitochondria are degraded and the interaction of the mitochondria with pathologically relevant proteins. Mitochondrial Dysfunction in Neurodegenerative Disorders provides an accessible, authoritative guide to this important area for neurologists; research and clinical neuroscientists; neuropathologists; and residents with an interest in clinical research.

Diagnosis and Management of Mitochondrial Disorders

Diagnosis and Management of Mitochondrial Disorders
Author: Michelangelo Mancuso,Thomas Klopstock
Publsiher: Springer
Total Pages: 382
Release: 2019-05-03
ISBN 10: 3030055175
ISBN 13: 9783030055172
Language: EN, FR, DE, ES & NL

Diagnosis and Management of Mitochondrial Disorders Book Review:

This book will help readers navigate the complexity of mitochondrial disorders, by addressing the role of mitochondrial dysfunction and the complex pathophysiological mechanisms associated with a growing number of illnesses, not only of neurological interest. Further, it provides updated concepts on genotype-phenotype correlations, clinical syndromes, diagnostic algorithms and therapies. Written by the world’s foremost mitochondrial researchers, the book comprehensively presents the state-of-the-art in mitochondrial medicine, making it of interest to a wide variety of specialists, including neurologists, geneticists, internists and biologists.

Clinical Mitochondrial Medicine

Clinical Mitochondrial Medicine
Author: Patrick F. Chinnery,Michael Keogh
Publsiher: Cambridge University Press
Total Pages: 226
Release: 2018-04-30
ISBN 10: 0521132983
ISBN 13: 9780521132985
Language: EN, FR, DE, ES & NL

Clinical Mitochondrial Medicine Book Review:

This interactive clinical textbook takes a system- and case-based approach in understanding mitochondrial disorders in clinical practice.

The Functions Disease Related Dysfunctions and Therapeutic Targeting of Neuronal Mitochondria

The Functions  Disease Related Dysfunctions  and Therapeutic Targeting of Neuronal Mitochondria
Author: J. Marie Hardwick
Publsiher: John Wiley & Sons
Total Pages: 448
Release: 2015-09-25
ISBN 10: 111901672X
ISBN 13: 9781119016724
Language: EN, FR, DE, ES & NL

The Functions Disease Related Dysfunctions and Therapeutic Targeting of Neuronal Mitochondria Book Review:

This book presents advances in the field of neuronal mitochondria – functions, relation to therapeutics, and pharmacology. For scientists and researchers in both industry and academia, this book provides detailed discussion, examples, and approaches, to illustrate the potential of mitochondria as therapeutic targets for neuronal diseases. • Helps readers understand the regulation of mitochondrial cellular processes, such as substrate metabolism, energy production, and programmed versus sporadic cell death • Offers insights on the development of strategies for targeted therapeutic approaches and potential personalized treatments • Includes examples of mitochondrial drugs, development, and mitochondria-targeted approaches for more efficient treatment methods and further developments in the field • Covers the model systems and approaches needed for the development of new drugs for the central nervous system to provide potential modern therapeutics for neurodegenerative disorders

Diagnosis and Management of Mitochondrial Disorders

Diagnosis and Management of Mitochondrial Disorders
Author: Michelangelo Mancuso,Thomas Klopstock
Publsiher: Springer
Total Pages: 382
Release: 2019-03-30
ISBN 10: 9783030055165
ISBN 13: 3030055167
Language: EN, FR, DE, ES & NL

Diagnosis and Management of Mitochondrial Disorders Book Review:

This book will help readers navigate the complexity of mitochondrial disorders, by addressing the role of mitochondrial dysfunction and the complex pathophysiological mechanisms associated with a growing number of illnesses, not only of neurological interest. Further, it provides updated concepts on genotype-phenotype correlations, clinical syndromes, diagnostic algorithms and therapies. Written by the world’s foremost mitochondrial researchers, the book comprehensively presents the state-of-the-art in mitochondrial medicine, making it of interest to a wide variety of specialists, including neurologists, geneticists, internists and biologists.

Mitochondrial Dysfunction in Ageing and Diseases

Mitochondrial Dysfunction in Ageing and Diseases
Author: Jaime M. Ross,Giuseppe Coppotelli,Lars Olson
Publsiher: MDPI
Total Pages: 542
Release: 2018-09-28
ISBN 10: 3038422517
ISBN 13: 9783038422518
Language: EN, FR, DE, ES & NL

Mitochondrial Dysfunction in Ageing and Diseases Book Review:

This book is a printed edition of the Special Issue "Mitochondrial Dysfunction in Ageing and Diseases" that was published in IJMS

Mitochondrial Disorders

Mitochondrial Disorders
Author: Claude Desnuelle
Publsiher: Springer Science & Business Media
Total Pages: 325
Release: 2013-12-01
ISBN 10: 2817809297
ISBN 13: 9782817809298
Language: EN, FR, DE, ES & NL

Mitochondrial Disorders Book Review:

The concept of mitochondrial diseases originated in 1962 with the description by Luft and coworkers of a patient with nonthyroidal hypermetabolism due to loose coupling of oxidation and phosphorylation in muscle mitochondria. Over the following quarter of a century, thanks to W. King Engel's "ragged-red fibres" as convenient markers for mitochondrial pathology, numerous papers described clinical, morphological, and biochemical features of "mitochondrial myopathies." In 1988 the discovery of mutations in mitochondrial DNA led to an explosive expansion of research into mitochondrial disorders. Throughout the 1990s the rapid identification of multiple mitochondrial gene defects associated with clinically diverse disorders has left practitioners puzzled about diagnosing such heterogeneous and complex syndromes. Through updated data, this book discusses now what Luft aptly called "mitochondrial medicine." In so doing, it considers the pivotal role of mitochondria in drug sensitivity, their key roles in ageing, apoptosis, and neurodegeneration along with primary mitochondrial diseases due to mutations in the nuclear genome, in the mitochondrial genome, or in the cross-talk between the two genomes.

Neuroscience for Neurologists

Neuroscience for Neurologists
Author: Patrick F Chinnery
Publsiher: World Scientific
Total Pages: 468
Release: 2006-11-14
ISBN 10: 1908979860
ISBN 13: 9781908979865
Language: EN, FR, DE, ES & NL

Neuroscience for Neurologists Book Review:

The last decade has seen major advances in our understanding of the basic scientific principles that underpin clinical neurology. Many of these advances have already had a major impact on routine clinical practice, and this is likely to continue in the future. Although this makes it an exciting time to practice neurology, it also presents new challenges. How can established general neurologists keep up-to-date with clinically relevant scientific advances, and how can the specialist remain competent outside his own field? What should trainee neurologists learn to prepare themselves for the future career? Written by experts in the field, this timely book presents the scientific principles behind neurology. It aims to take the reader from the human genome, through gene expression, to molecular and cellular pathology, and subsequently to contemporary clinical investigations and clinical trials. Each contribution includes a discussion about the future of the field and highlights areas of potential growth and their relevance to routine clinical practice over the next decade. The succinctly written chapters will be easily accessible to both neurologists and trainees who have no expertise in the area. Many of the chapters are co-written by a clinician and a basic scientist, and each has been subject to peer review — both by experts in the field and a “jobbing” general neurologist. This has ensured that the contributions reflect contemporary scientific thinking which is presented in a way that is easy to digest. The book includes generous use of diagrams to help explain difficult concepts, a glossary explaining the terminology, and provides information on links to web-based resources for further information. Contents:Neurogenetics — Single Gene DisordersNeurogenetics II: Complex DisordersFunctional Genomics and Proteomics: Application in NeurosciencesMitochondriaNanotechnology for Neuronal Ion ChannelsMolecular and Cellular Pathways of Neurodegeneration in Motor Neurone DiseaseNeurodegenerative Disorders: Parkinson's Disease and Huntington's DiseaseMolecular Pathogenesis of NeuroinflammationNeurovirologyMolecular Neurology of Prion DiseaseMonitoring and Interpretation of Intracranial PressureCerebral Perfusion and StrokeA Review of Structural Magnetic Resonance NeuroimagingApplications of Positron Emission Tomography (PET) in NeurologyFunctional Magnetic Resonance ImagingHow to Spot Bias and Other Potential Problems in Randomised Controlled Trials Readership: Neurologists, trainees/interns in neurology and related disciplines, neurobiologists. Keywords:Neuroscience;Neurology;Neurobiology;Clinical Neurology;Clinical InvestigationKey Features:A single volume describing the scientific principles that underpin the clinical practice of neurology from experts in each fieldCovers a broad range of topics from the human genome, through gene expression, to molecular and cellular pathology, and subsequently to contemporary clinical investigations and clinical trialsSuccinct chapters that will be easily accessible by neurologists and trainees who have no expertise in the areaIdeal for general neurologists who wish to keep up to date with clinically relevant scientific advancesEssential reading for trainee neurologists preparing for their future careerEffective use of diagrams to help explain difficult conceptsMany of the reviews co-written by a clinician and a basic scientist, in addition subjected to peer review — both by experts in the field and also by a “jobbing” general neurologistIncludes a glossary explaining the terminology, and providing links to web-based resources for further information

Mitochondrial Dynamics and Neurodegeneration

Mitochondrial Dynamics and Neurodegeneration
Author: Bingwei Lu
Publsiher: Springer Science & Business Media
Total Pages: 260
Release: 2011-05-16
ISBN 10: 9789400712911
ISBN 13: 940071291X
Language: EN, FR, DE, ES & NL

Mitochondrial Dynamics and Neurodegeneration Book Review:

Mitochondria are essential organelles in eukaryotic cells that control such diverse processes as energy metabolism, calcium buffering, and cell death. Recent studies have revealed that changes in mitochondrial morphology by fission and fusion, a process known as mitochondrial dynamics, is particularly important for neuronal function and survival. Defects in this process are commonly found in neurodegenerative diseases, offering a new paradigm for investigating mechanisms of neurodegeneration. To provide researchers working on neurodegenerative diseases and mitochondria with updated information on this rapidly progressing field, we have invited experts in the field to critically review recent progresses and identify future research directions. The topics include genetics of mitochondrial dynamics, mitochondrial dynamics and bioenergetics, autophagy, apoptosis, and axonal transport, and its role in neurological diseases, including Alzheimer’s, Parkinson’s, and Huntington’s diseases.

Mutations of Mitochondrial DNA Polymerase Gamma

Mutations of Mitochondrial DNA Polymerase Gamma
Author: Petri T. Luoma
Publsiher: Unknown
Total Pages: 80
Release: 2007
ISBN 10: 9789529228942
ISBN 13: 9529228945
Language: EN, FR, DE, ES & NL

Mutations of Mitochondrial DNA Polymerase Gamma Book Review:

Pharmacology of Mitochondria

Pharmacology of Mitochondria
Author: Harpreet Singh,Shey-Shing Sheu
Publsiher: Springer
Total Pages: 493
Release: 2017-08-11
ISBN 10: 3319573136
ISBN 13: 9783319573137
Language: EN, FR, DE, ES & NL

Pharmacology of Mitochondria Book Review:

This special book is conceived to highlight mitochondrial structural and functional integrity and how they are associated with several human diseases such as cardiovascular, cancer, renal, neurological disorder, and genetic disorders. The chapters contributed by leading mitochondrial researchers in the handbook will take us through the novel pharmacological strategies via mitochondria to understand their physiological and pathological role as well as present them as therapeutic targets.

Mitochondrial Disorders in Neurology 2

Mitochondrial Disorders in Neurology 2
Author: Anthony Henry Vernon Schapira,Salvatore DiMauro
Publsiher: Butterworth-Heinemann Medical
Total Pages: 304
Release: 2002
ISBN 10: 1928374650XXX
ISBN 13: UOM:39015055590924
Language: EN, FR, DE, ES & NL

Mitochondrial Disorders in Neurology 2 Book Review:

Gain practical explanations of the science underlying mitochondrial disorders in neurology. Written by leading experts, this new Blue Book helps you recognize and manage the diseases. Includes: Sections on the role of mitochondria in neurodegenerative disease The development of animal models for mitochondrial diseases The design of treatments for patients with mitochondrial defects