Epigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System
Author: Quan Lin,Yi E. Sun
Publsiher: Elsevier Inc. Chapters
Total Pages: 374
Release: 2012-12-31
ISBN 10: 0128058447
ISBN 13: 9780128058442
Language: EN, FR, DE, ES & NL

Epigenetic Regulation in the Nervous System Book Review:

Epigenetic Regulation of MicroRNAs in Chronic Lymphocytic Leukemia

Epigenetic Regulation of MicroRNAs in Chronic Lymphocytic Leukemia
Author: Constance Regina Bär
Publsiher: Unknown
Total Pages: 130
Release: 2013
ISBN 10: 1928374650XXX
ISBN 13: OCLC:869014201
Language: EN, FR, DE, ES & NL

Epigenetic Regulation of MicroRNAs in Chronic Lymphocytic Leukemia Book Review:

Epigenetic Gene Expression and Regulation

Epigenetic Gene Expression and Regulation
Author: Suming Huang,Michael D Litt,C. Ann Blakey
Publsiher: Academic Press
Total Pages: 482
Release: 2015-10-19
ISBN 10: 0128004711
ISBN 13: 9780128004715
Language: EN, FR, DE, ES & NL

Epigenetic Gene Expression and Regulation Book Review:

Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies. The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues. The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment. Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples. Reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies Helps readers understand how epigenetic marks are targeted, and to what extent transgenerational epigenetic changes are instilled and possibly passed onto offspring Chapters are replete with clinical examples to empower the basic biology with translational significance Offers more than 100 illustrations to distill key concepts and decipher complex science

Translating MicroRNAs to the Clinic

Translating MicroRNAs to the Clinic
Author: Jeffrey Laurence
Publsiher: Academic Press
Total Pages: 392
Release: 2016-09-17
ISBN 10: 0128005548
ISBN 13: 9780128005545
Language: EN, FR, DE, ES & NL

Translating MicroRNAs to the Clinic Book Review:

Translating microRNA to the Clinic reviews the possibilities of current methodological tools and experimental approaches used by leading translational researchers. The book features the uses of micro ribonucleic acid as deployed in cancer targeting in biomarkers, diabetes, cardiovascular disease, and neurodegeneration, among many others. Pedagogically, the work concentrates on the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field, promoting a cross-disciplinary communication between the sub-specialities of medicine, but in common with other books on the topic. In addition, the book emphasizes recent innovations, critical barriers to progress, the new tools that are being used to overcome them, and specific areas of research that require additional study to advance the field as a whole. Encompasses the latest innovations and tools being used to apply microRNA from lab to clinic“/li> Extensive pedagogical updates aiming to improve the education of translational researchers in this field Transdisciplinary approach aims to support cross-fertilization between different sub-specialties of medicine

Essentials of Noncoding RNA in Neuroscience

Essentials of Noncoding RNA in Neuroscience
Author: Davide De Pietri Tonelli
Publsiher: Academic Press
Total Pages: 338
Release: 2017-06-14
ISBN 10: 0128498994
ISBN 13: 9780128498996
Language: EN, FR, DE, ES & NL

Essentials of Noncoding RNA in Neuroscience Book Review:

Essentials of Noncoding RNA in Neuroscience: Ontogenetics, Plasticity of the Vertebrate Brain focuses on the role of miRNAs in neurogenesis, gliogenesis, neuronal network formation, and the cell biology of forebrain development. The important role miRNAs play in neuronal maturation, neocortex function, and in some neurodevelopmental disorders is discussed, as are the computational challenges and methods used in the identification of miRNA targets. This book is a valuable reference for neuroscientists who wish to better understand the role of miRNAs in complex processes. It is of strong interest to those working to develop enabling technologies to detect and monitor miRNA expression and function, and to evaluate its roles in neural progenitor proliferation/differentiation, neuronal plasticity, and learning and memory. Discusses the unique features of neural miRNAs Details functional investigation of miRNA actions and current experimental approaches Includes extensive coverage of miRNA biology, developmental and postnatal neurogenesis, and computational challenges for miRNA target identification Contains thorough discussion of the transcriptional control of miRNA expression in forebrain development and in specific neuronal subtypes, as well as miRNA function in neurogenesis, neuronal network maturation, plasticity, gliogenesis, and dysfunction Provides an overview of miRNA roles in neurodevelopmental disorders and their possible role in the evolution of the neocortex

RNA Mediated Processes in Epigenetics an Integrative View in the Maintenance of Homeostasis

RNA Mediated Processes in Epigenetics  an Integrative View in the Maintenance of Homeostasis
Author: Bertrand Kaeffer,Hanna Taipaleenmäki,Sandra Lopes De Souza
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2021-03-01
ISBN 10: 2889665259
ISBN 13: 9782889665259
Language: EN, FR, DE, ES & NL

RNA Mediated Processes in Epigenetics an Integrative View in the Maintenance of Homeostasis Book Review:

Epigenetics of B Cells and Antibody Responses

Epigenetics of B Cells and Antibody Responses
Author: Paolo Casali
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2016-04-12
ISBN 10: 2889197905
ISBN 13: 9782889197903
Language: EN, FR, DE, ES & NL

Epigenetics of B Cells and Antibody Responses Book Review:

Epigenetics is the study of changes in gene activity that are heritable but not caused by changes in the DNA sequence. By modulating gene activities, epigenetic changes regulate cell functions. They include DNA methylation, histone posttranslational modifications and gene silencing by the action of non-coding RNAs, particularly microRNAs. It is now clear that epigenetic changes regulate B cell development. By acting in concert with networks of transcription factors, they modulate the activation of B cell lineage specific gene programs and repress inappropriate gene transcription in particular B cell differentiation states.

A hallmark of B cell development in the bone marrow is the assembly of the B cell receptor (BCR) for antigen through rearrangement of immunoglobulin heavy (IgH) and light (IgL) chain V(D)J genes, as mediated by RAG1/RAG2 recombinases. Ig V(D)J rearrangement critically times the progression from pro-B cell to pre-B cell and, finally, mature B cell. Such progression is modulated by epigenetic marks, such as DNA methylation and histone posttranslational modifications, that increase chromatin accessibility and target RAG/RAG2 to V, D and J DNA. It is also dependent on the expression of multiple microRNAs. Mice deficient in Ago2, which is essential for microRNA biogenesis and function, have B cell development blocked at the pro-B cell stage. In agreement with this, B cell specific ablation of microRNA by B cell-specific knockout of Dicer virtually blocks B cell differentiation at the pro-B to pre-B cell transition.

After mature B cells encounter antigen, changes of the epigenetic landscape are induced by the same stimuli that drive the antibody response; such epigenetic changes underpin the maturation of the antibody response itself. They instruct those B cell differentiation processes, somatic hypermutation (SHM), class switch DNA recombination (CSR) and plasma cell differentiation, that are central to the maturation of the antibody response as well as differentiation of memory B cells. Inducible histone modifications, together with DNA methylation and microRNAs modulate the transcriptome, particularly the expression of activation-induced cytidine deaminase (AID), central to SHM and CSR, and B lymphocyte-induced maturation protein-1 (Blimp-1), which is central to plasma cell differentiation.

Combinatorial histone modifications also function as histone codes in the targeting of the CSR and, possibly, the SHM machinery to the Ig locus by recruiting specific adaptors (histone code readers) that can in turn target and/or stabilize CSR/SHM factors. Epigenetic alterations in memory B cells contribute to their functionally distinction from their naive counterparts. Memory B cells inherit epigenetic information from their precursors and acquire new epigenetic marks, which make these resting B cells poised to promptly respond to antigen. The cross/feedback regulation of different epigenetic modifications/elements further increases the complexity of the B cell epigenome, which interacts with the genetic information for precise modulation of gene expression. It is increasingly evident that epigenetic dysregulation in B cells, including aberrant expression of microRNAs, can result in aberrant antibody responses to microbial pathogens, emergence of pathogenic autoantibodies or B cell neoplastic transformation. Epigenetic marks are potential targets for new therapeutics in autoimmunity and B cell malignancy.

Epigenetics of Chronic Pain

Epigenetics of Chronic Pain
Author: Anonim
Publsiher: Academic Press
Total Pages: 248
Release: 2018-10-29
ISBN 10: 0128140712
ISBN 13: 9780128140710
Language: EN, FR, DE, ES & NL

Epigenetics of Chronic Pain Book Review:

Epigenetics of Chronic Pain, Volume Nine, presents comprehensive information on the role of epigenetics in chronic pain sensitivity, providing a detailed, but accessible, view of the field from basic principles, to clinical application. Leading international researchers discuss essential mechanisms of chronic pain epigenetics, including the molecular processes of chromatin remodeling, histone modifications, and the microRNAs and noncoding RNAs involved in regulating genes tied to pain sensitivity. The influence of epigenetics in inflammatory, neuropathic, visceral and other pain models is examined, with data derived from epigenetic studies on peripheral and central mechanisms of pain sensitivity in animal models and clinical cases studies. The studies and case examples cited highlight therapeutic pathways of significance and next steps for researchers to develop epigenetic-based treatments for chronic pain. In recent years, epigenetic regulation of gene expression has been shown to play a central role in managing human pain sensitivity. Findings show that expression of many genes critical to increases or decreases in pain sensitivity are indeed regulated by DNA methylation and its enzymes, histone-involved chromatin remodeling, and noncoding RNAs, mainly microRNAs. Compiles all known information on epigenetic regulation of chronic pain in one volume Covers the basic functionality of epigenetic mechanisms involved in pain management, applications of recent research in understanding different types of chronic pain, and pathways for developing therapeutics Leading international researchers from across academia, clinical settings, and the pharmaceutical industry discuss epigenetics in inflammatory, neuropathic, visceral, and other pain models in-depth Enables clinicians, researchers, and pharmacologists to better understand and treat chronic pain

Cell Free Circulating Dna Purification and Analysis Techniques

Cell Free Circulating Dna  Purification and Analysis Techniques
Author: Kristina Warton,Goli Samimi
Publsiher: Unknown
Total Pages: 135
Release: 2022-02-12
ISBN 10: 9789811244674
ISBN 13: 9811244677
Language: EN, FR, DE, ES & NL

Cell Free Circulating Dna Purification and Analysis Techniques Book Review:

The aims of the book are to bring together expertise in working with circulating DNA from blood, and systematically address technical aspects of each step from blood collection through DNA purification and analysis, as well as commercial considerations for circulating DNA-based diagnostics. Since circulating DNA offers non-invasive 'liquid biopsy' access to the cancer genome, there has been a great deal of excitement in both academic and commercial spheres about its use it for diagnostic applications in cancer.Cell-free circulating DNA is found in blood plasma, and is not associated with any cell fraction. While the origin and biological function of cell-free DNA is poorly understood, it has many potential clinical applications. In pregnant women, a fraction of the cell-free DNA is of fetal origin and forms the basis of Non-Invasive Pre-natal Testing (NIPT). NIPT has been a tremendous clinical and commercial success, replacing previously established diagnostic tests and decreasing the number of unnecessary invasive procedures.In patients with cancer, a proportion of the cell-free DNA in plasma is derived from the tumour. Since cancer is a disease driven by underlying DNA abnormality, access to tumour DNA via a simple blood sample promises information about a range of tumour properties including mutations, drug sensitivity, and changes in tumour burden during treatment. In the age of targeted cancer therapies, these are all important to cancer treatment. Perhaps most excitingly, cell-free DNA detection has the potential for diagnosing cancer early, when surgical removal effects a cure without the need for further drug treatment.The aim of the book is to bring together expert opinion on techniques for working with circulating DNA and identify and resolve the technical issues that hamper the development of effective circulating DNA based diagnostics.

Pitx2 Expression and Epigenetic Regulation of Muscle Cell Differentiation

Pitx2 Expression and Epigenetic Regulation of Muscle Cell Differentiation
Author: Jing Rong
Publsiher: Unknown
Total Pages: 206
Release: 2014
ISBN 10: 1928374650XXX
ISBN 13: OCLC:884399587
Language: EN, FR, DE, ES & NL

Pitx2 Expression and Epigenetic Regulation of Muscle Cell Differentiation Book Review:

Epigenetic modifications are heritable, stable and potentially reversible changes in gene expression, and occur without change in DNA sequence. These changes may involve DNA methylation, histone acetylation, or regulation of non-coding RNAs such as microRNAs. The significance of epigenetic modifications has been highlighted in human diseases ranging from inherited cancer to muscular dystrophy. In our previous study, significant DNA methylation change of paired-like homedomain 2 (Pitx2) gene was found in human skeletal muscle of the kwashiorkor and marasmus survivors; three CpG sites on Pitx2 were differentially methylated. Therefore, this study explores the relationship between Pitx2 expression and epigenetic modifications, in particular DNA methylation and microRNA regulation, during myogenic differentiation by using the murine C2C12 myoblast cell line as an in vitro muscle cell model. It was found that Pitx2 expression change during myogenic differentiation in C2C12 myoblasts was not accompanied by the DNA methylation change in the three CpG sites of interest. In addition, following Pitx2 knock-down and myogenic differentiation in C2C12 myoblasts, two myogenic regulators Myf5 and Myogenin were up-regulated and microRNA miR-127 and miR-486 expression were significantly inhibited. In addition, miR-27a, miR-29b and miR-133a tended to decrease following Pitx2 knock-down. Overall data suggest that Pitx2 may participate in the myogenic regulatory network through regulating microRNA at least via miR-486. Furthermore, results from this study also suggest that Myogenin may be an important mediator in these regulatory pathways.

Epigenetic Biomarkers and Diagnostics

Epigenetic Biomarkers and Diagnostics
Author: José Luis García-Giménez
Publsiher: Academic Press
Total Pages: 696
Release: 2015-12-07
ISBN 10: 0128019212
ISBN 13: 9780128019214
Language: EN, FR, DE, ES & NL

Epigenetic Biomarkers and Diagnostics Book Review:

Epigenetic Biomarkers and Diagnostics comprises 31 chapters contributed by leading active researchers in basic and clinical epigenetics. The book begins with the basis of epigenetic mechanisms and descriptions of epigenetic biomarkers that can be used in clinical diagnostics and prognostics. It goes on to discuss classical methods and next generation sequencing-based technologies to discover and analyze epigenetic biomarkers. The book concludes with an account of DNA methylation, post-translational modifications and noncoding RNAs as the most promising biomarkers for cancer (i.e. breast, lung, colon, etc.), metabolic disorders (i.e. diabetes and obesity), autoimmune diseases, infertility, allergy, infectious diseases, and neurological disorders. The book describes the challenging aspects of research in epigenetics, and current findings regarding new epigenetic elements and modifiers, providing guidance for researchers interested in the most advanced technologies and tested biomarkers to be used in the clinical diagnosis or prognosis of disease. Focuses on recent progress in several areas of epigenetics, general concepts regarding epigenetics, and the future prospects of this discipline in clinical diagnostics and prognostics Describes the importance of the quality of samples and clinical associated data, and also the ethical issues for epigenetic diagnostics Discusses the advances in epigenomics technologies, including next-generation sequencing based tools and applications Expounds on the utility of epigenetic biomarkers for diagnosis and prognosis of several diseases, highlighting the study of these biomarkers in cancer, cardiovascular and metabolic diseases, infertility, and infectious diseases Includes a special section that discusses the relevance of biobanks in the maintenance of high quality biosamples and clinical-associated data, and the relevance of the ethical aspects in epigenetic studies

Epigenetic Mechanisms in Cancer

Epigenetic Mechanisms in Cancer
Author: Sabita Saldanha
Publsiher: Academic Press
Total Pages: 392
Release: 2017-11-16
ISBN 10: 0128134607
ISBN 13: 9780128134603
Language: EN, FR, DE, ES & NL

Epigenetic Mechanisms in Cancer Book Review:

Epigenetic Mechanisms in Cancer provides a comprehensive analysis of epigenetic signatures that govern disease development, progression and metastasis. Epigenetic signatures dictating tumor etiologies present an opportunity for biomarker identification which has broad potential for improving diagnosis, prognosis, prediction, and risk assessment. This volumes offers a unique evaluation of signature differences in childhood, sex-specific and race-specific cancers, and in doing so broadly illuminates the scope of epigenetic biomarkers in clinical environments. Chapters detail the major epigenetic process in humans consisting of DNA methylation, histone modifications and microRNAs (miRNAs) involved in the initiation, progression and metastasis of tumors. Also delineated are recent technologies such as next generation sequencing that are used to identify epigenetic profiles (primarily methylation analysis) in samples (normal, benign and cancerous) and which are highly important to the analysis of epigenetic outcomes. Offers broad coverage that is applicable to audiences in various area of cancer research - population studies, diagnostics, prognosis, prediction, therapy, risk, etc. Provides critical review analysis of the topics that will clarify and delineate the potential roles of epigenetic signatures in cancer management Covers basic, as well as, clinical areas of epigenetic mechanisms in tumorigenesis Features contributions by leading experts in the field Provides comprehensive coverage of current epigenetic signatures involved in the etiology of various cancers and miRNAs

Endothelium and Cardiovascular Diseases

Endothelium and Cardiovascular Diseases
Author: Protasio Lemos Da Luz,Peter Libby,Francisco Rafael Martins Laurindo,Antonio Carlos Palandri Chagas
Publsiher: Academic Press
Total Pages: 758
Release: 2018-02-03
ISBN 10: 0128125519
ISBN 13: 9780128125519
Language: EN, FR, DE, ES & NL

Endothelium and Cardiovascular Diseases Book Review:

Endothelium and Cardiovascular Diseases: Vascular Biology and Clinical Syndromes provides an in-depth examination of the role of endothelium and endothelial dysfunction in normal vascular function, and in a broad spectrum of clinical syndromes, from atherosclerosis, to cognitive disturbances and eclampsia. The endothelium is a major participant in the pathophysiology of diseases, such as atherosclerosis, diabetes and hypertension, and these entities are responsible for the largest part of cardiovascular mortality and morbidly. Over the last decade major new discoveries and concepts involving the endothelium have come to light. This important reference collects this data in an easy to reference resource. Written by known experts, and covering all aspects of endothelial function in health and disease, this reference represents an assembly of recent knowledge that is essential to both basic investigators and clinicians. Provides a complete overview of endothelial function in health and diseases, along with an assessment of new information Includes coverage of groundbreaking areas, including the artificial LDL particle, the development of a new anti-erectile dysfunction agent, a vaccine for atherosclerosis, coronary calcification associated with red wine, and the interplay of endoplasmic reticulum/oxidative stress Explores the genetic features of endothelium and the interaction between basic knowledge and clinical syndromes

Interplay of Epigenetics with Gynecological Cancer

Interplay of Epigenetics with Gynecological Cancer
Author: Coralia Bleotu
Publsiher: Unknown
Total Pages: 135
Release: 2016
ISBN 10: 1928374650XXX
ISBN 13: OCLC:1154156746
Language: EN, FR, DE, ES & NL

Interplay of Epigenetics with Gynecological Cancer Book Review:

Recent data on the cell deregulation that occurs during the progression to cancer underlines the cooperation between genetic and epigenetic alterations leading to a malignant phenotype. Unlike genetic alterations, the epigenetic changes do not affect the DNA sequence of the genes, but determine the regulation of gene expression acting upon the genome. Moreover, unlike genetic changes, epigenetic ones are reversible, making them therapeutic targets in various conditions in general and in cancer disease in particular. The term epigenetics includes a series of covalent modifications that regulate the methylation pattern of DNA and posttranslational modifications of histones. Gene expression can also be regulated at the posttranscriptional level by microRNAs (miRNAs), a family of small noncoding RNAs that inhibit the translation of mRNA to protein. miRNAs can act as 'oncomiRs', as tumor suppressors, or both. In this chapter, we will (1) summarize the current literature on the key processes responsible for epigenetic regulation: DNA methylation, histone modifications and posttranscriptional gene regulation by miRNAs; (2) evaluate aberrant epigenetic modifications as essential players in cancer progression; (3) establish the roles of microenvironment-mediated epigenetic perturbations in the development of gynecological neoplasia; (4) evaluate epigenetic factors involved in drug resistance.

Gene Expression and Regulation in Mammalian Cells

Gene Expression and Regulation in Mammalian Cells
Author: Fumiaki Uchiumi
Publsiher: BoD – Books on Demand
Total Pages: 372
Release: 2018-02-28
ISBN 10: 9535138677
ISBN 13: 9789535138679
Language: EN, FR, DE, ES & NL

Gene Expression and Regulation in Mammalian Cells Book Review:

Sixty years after the "central dogma," great achievements have been developed in molecular biology. We have also learned the important functions of noncoding RNAs and epigenetic regulations. More importantly, whole genome sequencing and transcriptome analyses enabled us to diagnose specific diseases. This book is not only intended for students and researchers working in laboratory but also physicians and pharmacists. This volume consists of 14 chapters, divided into 4 parts. Each chapter is written by experts investigating biological stresses, epigenetic regulation, and functions of transcription factors in human diseases. All articles presented in this volume by excellent investigators provide new insights into the studies in transcriptional control in mammalian cells and will inspire us to develop or establish novel therapeutics against human diseases.

MicroRNAs in Diseases and Disorders

MicroRNAs in Diseases and Disorders
Author: Philip V Peplow,Bridget Martinez,George A Calin,Aurora Esquela-Kerscher
Publsiher: Royal Society of Chemistry
Total Pages: 480
Release: 2019-05-07
ISBN 10: 1788017811
ISBN 13: 9781788017817
Language: EN, FR, DE, ES & NL

MicroRNAs in Diseases and Disorders Book Review:

From pathology to treatment, MicroRNAs in Diseases and Disorders highlights the role of microRNAs (miRNAs) in the development and progression of a variety of diseases, including cancer, neurological disease, endocrine disease and autoimmune disease, and underscores the utilization of miRNA targets in the treatment of these conditions. Providing a comprehensive account, this book also includes the identification of miRNAs as diagnostic and prognostic biomarkers for disease, as well as evaluates translational value from clinical trials using synthesized and functionalized miRNA mimics and inhibitors. With a global contribution list and chapters from leading experts across the field, MicroRNAs in Diseases and Disorders is an invaluable reference to miRNA researchers and health professionals in a variety of disease areas in government, academia and industry. The book will also appeal to pharmaceutical and medicinal chemists with an interest in miRNA targeting therapeutics, as well as to advanced students in chemical biology and drug discovery.

Nutritional Epigenomics

Nutritional Epigenomics
Author: Anonim
Publsiher: Academic Press
Total Pages: 478
Release: 2019-07-20
ISBN 10: 0128173106
ISBN 13: 9780128173107
Language: EN, FR, DE, ES & NL

Nutritional Epigenomics Book Review:

Nutritional Epigenomics offers a comprehensive overview of nutritional epigenomics as a mode of study, along with nutrition’s role in the epigenomic regulation of disease, health and developmental processes. Here, an expert team of international contributors introduces readers to nutritional epigenomic regulators of gene expression, our diet’s role in epigenomic regulation of disease and disease inheritance, caloric restriction and exercise as they relate to recent epigenomic findings, and the influence of nutritional epigenomics over circadian rhythms, aging and longevity, and fetal health and development, among other processes. Disease specific chapters address metabolic disease (obesity and diabetes), cancer, and neurodegeneration, among other disorders. Diet-gut microbiome interactions in the epigenomic regulation of disease are also discussed, as is the role of micronutrients and milk miRNAs in epigenetic regulation. Finally, chapter authors examine ongoing discussions of race and ethnicity in the social-epigenomic regulation of health and disease. Empowers the reader to employ nutritional epigenomics approaches in their own research Discusses the latest topics in nutritional epigenomics in the regulation of aging, circadian rhythm, inheritance and fetal development, as well as metabolism and disease Offers a full grounding in epigenetic reprogramming and nutritional intervention in the treatment and prevention of disease, as informed by population-based studies

Cancer and Noncoding RNAs

Cancer and Noncoding RNAs
Author: Jayprokas Chakrabarti,Sanga Mitra
Publsiher: Academic Press
Total Pages: 576
Release: 2017-10-13
ISBN 10: 0128134372
ISBN 13: 9780128134375
Language: EN, FR, DE, ES & NL

Cancer and Noncoding RNAs Book Review:

Cancer and Noncoding RNAs offers an in-depth exploration of noncoding RNAs and their role in epigenetic regulation of complex human disease, most notably cancer. In addition to examining microRNAs, this volume provides a unique evaluation of more recently profiled noncoding RNAs now implicated in carcinogenesis, including lncRNAs, piRNAs, circRNAs, and tRNAs, identifying differences in function between these noncoding RNAs and how they interact with the rest of the epigenome. A broad range of chapters from experts in the field detail epigenetic regulation of various cancer types, along with recent next generation sequencing technologies, genome-wide association studies (GWAS) and bioinformatics approaches. This book will help researchers in genomic medicine and cancer biology better understand the role of noncoding RNAs in epigenetics, aiding in the development of useful biomarkers for diagnosis, prognosis and new RNA-based disease therapies. Provides a comprehensive analysis of noncoding RNAs implicated in epigenetic regulation of gene expression and chromatin dynamics Educates researchers and graduate students by highlighting, in addition to miRNAs, a range of noncoding RNAs newly associated with carcinogenesis Applies current knowledge of noncoding RNAs and epigenomics towards developing cancer and RNA-based disease therapies Features contributions by leading experts in the field

Kallikrein related Peptidases

Kallikrein related Peptidases
Author: Viktor Magdolen
Publsiher: De Gruyter
Total Pages: 409
Release: 2012
ISBN 10: 9783110260366
ISBN 13: 3110260360
Language: EN, FR, DE, ES & NL

Kallikrein related Peptidases Book Review:

The KLK proteins and their encoding genes are increasingly attracting attention among scientists and clinicians worldwide as they represent interesting and functionally distinct biomarkers both under physiological and pathophysiological conditions. This volume on kallikrein-related peptidases (KLKs) reviews the characterization, regulation, and interactions of these proteases within the protease web.

Epigenetics in Psychiatry

Epigenetics in Psychiatry
Author: Jacob Peedicayil,Dennis R. Grayson,Dimitri Avramopoulos
Publsiher: Academic Press
Total Pages: 846
Release: 2021-08-16
ISBN 10: 0128235780
ISBN 13: 9780128235782
Language: EN, FR, DE, ES & NL

Epigenetics in Psychiatry Book Review:

Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry. This new edition has been fully revised to address recent advances in epigenetic understanding of psychiatric disorders, evoking data consortia (e.g., CommonMind, ATAC-seq), single cell analysis, and epigenome-wide association studies to empower new research. The book also examines epigenetic effects of the microbiome on psychiatric disorders, and the use of neuroimaging in studying the role of epigenetic mechanisms of gene expression. Ongoing advances in epigenetic therapy are explored in-depth. Fully revised to discuss new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics in psychiatric disease Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and proteins Catalyzes knowledge discovery in both basic epigenetic biology and epigenetic targets for drug discovery Provides guidance in research methods and protocols, as well how to employ data from consortia, single cell analysis, and epigenome-wide association studies (EWAS) Features chapter contributions from international leaders in the field