Methods of Therapeutic Drug Monitoring Including Pharmacogenetics

Methods of Therapeutic Drug Monitoring Including Pharmacogenetics
Author: Georg Hempel
Publsiher: Elsevier
Total Pages: 380
Release: 2019-10-17
ISBN 10: 0444640673
ISBN 13: 9780444640673
Language: EN, FR, DE, ES & NL

Methods of Therapeutic Drug Monitoring Including Pharmacogenetics Book Review:

Methods of Therapeutic Drug Monitoring Including Pharmacogenetics, Second Edition, Volume Seven in the Handbook of Analytical Separations series, covers all aspects of drug monitoring, including laboratory work, pharmacokinetic analysis and clinical aspects, thus enabling readers from different fields to understand the whole process of therapeutic drug monitoring and how to avoid common pitfalls. The book contains analytical techniques for the quantification of drugs, along with pharmacogenetic and pharmacogenomic methods. Also included are updates on sample preparation, including dried blood spot technology and microextraction methods. In addition, the book includes new drugs, such as tyrosine kinase inhibitors and the monitoring of immunosuppressant drugs. Presents a unique, interdisciplinary approach that appeals to a wide range of users Written by authors from international labs, providing a global perspective that can be applied in various regulatory environments Features additional therapeutic drugs to reflect the rising number of immunocompromised patients Includes a new mass spectroscopic methods chapter to capture the frequent use in TDM and the improved availability of LC-MS across laboratories

Therapeutic Drug Monitoring Data

Therapeutic Drug Monitoring Data
Author: Amitava Dasgupta,Matthew Krasowski
Publsiher: Academic Press
Total Pages: 382
Release: 2019-09-14
ISBN 10: 0128158506
ISBN 13: 9780128158500
Language: EN, FR, DE, ES & NL

Therapeutic Drug Monitoring Data Book Review:

Therapeutic Drug Monitoring Data: A Concise Guide, Fourth Edition serves as a ready resource of information on commonly monitored drugs that will help readers make decisions relating to the monitoring and interpretation of results. It is an easy-to-read source of information on intended use, pharmacokinetics, therapeutic range, and toxic concentrations, as well as bioavailability, disposition, metabolism and the excretion of commonly monitored therapeutic drugs. This fully updated fourth edition includes sections on new anticonvulsants, anti-depressant and anti-HIV drugs, new drugs for advanced cancer treatment, and thoroughly updated chapters that address new pitfalls and problems in the lab. Serves as a ready resource of information for commonly monitored drugs Presents a useful, quick guide for those making decisions related to monitoring and interpretation of results Provides concise, easily digestible content for clinical laboratory scientists, toxicologists and clinicians

Handbook of Drug Monitoring Methods

Handbook of Drug Monitoring Methods
Author: Amitava Dasgupta
Publsiher: Springer Science & Business Media
Total Pages: 446
Release: 2007-10-05
ISBN 10: 1597450316
ISBN 13: 9781597450317
Language: EN, FR, DE, ES & NL

Handbook of Drug Monitoring Methods Book Review:

Written in a handbook style with specific methods and tips on eliminating false positive and false negative results, this book is a practical guide to the detailed mechanisms of such occurrences.

Personalized Immunosuppression in Transplantation

Personalized Immunosuppression in Transplantation
Author: Michael Oellerich,Amitava Dasgupta
Publsiher: Elsevier
Total Pages: 316
Release: 2015-08-08
ISBN 10: 0128011335
ISBN 13: 9780128011331
Language: EN, FR, DE, ES & NL

Personalized Immunosuppression in Transplantation Book Review:

Personalized Immunosuppression in Transplantation: Role of Biomarker Monitoring and Therapeutic Drug Monitoring provides coverage of the various approaches to monitoring immunosuppressants in transplant patients, including the most recently developed biomarker monitoring methods, pharmacogenomics approaches, and traditional therapeutic drug monitoring. The book is written for pathologists, toxicologists, and transplant surgeons who are involved in the management of transplant patients, offering them in-depth coverage of the management of immunosuppressant therapy in transplant patients with the goal of maximum benefit from drug therapy and minimal risk of drug toxicity. This book also provides practical guidelines for managing immunosuppressant therapy, including the therapeutic ranges of various immunosuppressants, the pitfalls of methodologies used for determination of these immunosuppressants in whole blood or plasma, appropriate pharmacogenomics testing for organ transplant recipients, and when biomarker monitoring could be helpful. Focuses on the personalized management of immunosuppression therapy in individual transplant patients Presents information that applies to many areas, including gmass spectrometry, assay design, assay validation, clinical chemistry, and clinical pathology Provides practical guidelines for the initial selection and subsequent modifications of immunosuppression therapy in individual transplant patients Reviews the latest research in biomarker monitoring in personalizing immunosuppressant therapy, including potential new markers not currently used, but with great potential for future use Explains how monitoring graft-derived, circulating, cell free DNA has shown promise in the early detection of transplant injury in liquid biopsy

Therapeutic Drug Monitoring

Therapeutic Drug Monitoring
Author: Amitava Dasgupta
Publsiher: Academic Press
Total Pages: 459
Release: 2012
ISBN 10: 0123854679
ISBN 13: 9780123854674
Language: EN, FR, DE, ES & NL

Therapeutic Drug Monitoring Book Review:

Therapeutic Drug Monitoring: Newer Drugs and Biomarkers features timely topics such as the monitoring of classical and newer drugs, pharmacogenomics and the application of biomarkers in therapeutic drug monitoring. This reference also discusses the limitations of current commercially available immunoassays for therapeutic monitoring. It presents new and sophisticated techniques used for proper determination of blood levels and the clinical utility of therapeutic drug monitoring of contemporary drugs. Written by leading international experts and geared toward clinical pathologists, toxicologists, clinical chemists, laboratory professionals and physicians, this book is an essential resource on the current practice of therapeutic drug monitoring in improving patient safety. Includes both the technical and clinical issues associated with therapeutic drug monitoring. Discusses the utility of therapeutic drug monitoring of newer drugs such as antiretroviral agents, anticonvulsants, antidepressants etc. Provides up-to-date information on issues in pharmacogenomics and personalized medicine with emphasis on therapy with warfarin, certain anticancer drugs and antidepressants. Covers important content on the limitations of commercially available immunoassays (chemical tests) for therapeutic drug monitoring and additional analytical techniques.

Drug Monitoring and Clinical Chemistry

Drug Monitoring and Clinical Chemistry
Author: Georg Hempel
Publsiher: Elsevier
Total Pages: 378
Release: 2004-05-15
ISBN 10: 0080530540
ISBN 13: 9780080530543
Language: EN, FR, DE, ES & NL

Drug Monitoring and Clinical Chemistry Book Review:

Drug Monitoring and Clinical Chemistry, the 5th volume in the Handbook of Analytical Separations series, gives an overview about methods to analyse drugs in biological fluids. The most widely used methods to analyse drugs in biological fluids. i.e. chromatographic methods, CE and immunoassays are described in detail. For important drugs, an overview about the methods available and a comparison of the techniques should be given to enable the reader to choose the right method depending on laboratory equipment, staff, the aim of the investigation etc. Other general aspects important for conducting therapeutic drug monitoring or pharmacokinetics studies are also covered, i.e. sample preparation, validation of the analytical methods and pharmacokinetic methods for interpreting the data. Areas where therapeutic drug monitoring is used frequently such as antibiotics, immunosuppressant drugs, antipsychotic and anticancer drugs will be discussed in detail. In addition, the important field of phenotyping and genotyping for therapy optimisation with special focus on real-life applications is also covered. The book contains important information for analyst working on drug analysis in clinical chemistry, hospital pharmacists involved in therapeutic drug monitoring, other pharmacists, chemists or physicians working on pharmacokinetic studies in industry or academia. In contrast to other books in this field, this book provides up-to-date information regarding both methodology and clinical applications. For the applications, only fields are described where therapeutic drug monitoring is used in clinical routine and provides benefit to the patients. Overview of all important field where therapeutic drug monitoring is applied All relevant analytical and computational methods are discussed Written by experts with a lot of practical experience in the field

Applied Pharmacokinetics

Applied Pharmacokinetics
Author: William E. Evans,Jerome J. Schentag,William J. Jusko
Publsiher: Applied Therapeutics, Incorporated
Total Pages: 1202
Release: 1992
ISBN 10: 9780915486151
ISBN 13: 0915486156
Language: EN, FR, DE, ES & NL

Applied Pharmacokinetics Book Review:

The Third Edition of Applied Pharmacokinetics remains the gold standard by which all other clinical pharmacokinetics texts are measured. Written by leading pharmacokinetics researchers and practitioners, this book is the most advanced kinetics reference available. All chapters have been extensively updated or completely rewritten for this edition, and six new chapters have been added on pharmacodynamics, pharmacogenetics, pharmacokinetic considerations in the obese, dietary influences on drug disposition, zidovudine, and corticosteroids. Each chapter is tightly focused on the most important concepts and issues. Chapters on specific drugs are organized in a consistent format for quick, easy information retrieval. Major subheadings include Clinical Pharmacokinetics, Pharmacodynamics, Clinical Application of Pharmacokinetic Data, Analytical Methods, and Prospectus.

Pharmacogenomics in Clinical Therapeutics

Pharmacogenomics in Clinical Therapeutics
Author: Loralie J. Langman,Amitava Dasgupta
Publsiher: John Wiley & Sons
Total Pages: 400
Release: 2012-01-09
ISBN 10: 1119959586
ISBN 13: 9781119959588
Language: EN, FR, DE, ES & NL

Pharmacogenomics in Clinical Therapeutics Book Review:

Pharmacogenomics is the basis of personalized medicine which will be the medicine of the future. Through both reducing the numbers of adverse drug reactions and improving the use of existing drugs in targeted populations, pharmacogenomics represents a real advance on traditional therapeutic drug monitoring. Pharmacogenomics in Clinical Therapeutics provides an introduction to the principles of pharmacogenomics before addressing the pharmacogenomic aspects of key therapeutic areas such as warfarin therapy, cancer chemotherapy, therapy with immunosuppressants, antiretroviral therapy, and psychoactive drugs. It also includes methods of pharmacogenomic testing and the pharmacogenomic aspects of drug–drug interactions. From a team of expert contributors, Pharmacogenomics in Clinical Therapeutics is a comprehensive overview of the current state of pharmacogenomics in pharmacotherapy for all clinicians, pharmacologists and clinical laboratory professionals. It is also a guide for practicing clinicians and health care professionals to the basic principles of pharmacogenomics, laboratory tests currently available to aid clinicians, and the future promise of this developing field.

Handbook of Analytical Therapeutic Drug Monitoring and Toxicology 1996

Handbook of Analytical Therapeutic Drug Monitoring and Toxicology  1996
Author: Steven H.Y. Wong,Irving Sunshine
Publsiher: CRC Press
Total Pages: 366
Release: 2017-11-22
ISBN 10: 1351364278
ISBN 13: 9781351364270
Language: EN, FR, DE, ES & NL

Handbook of Analytical Therapeutic Drug Monitoring and Toxicology 1996 Book Review:

Adapting modern advances in analytical techniques to daily laboratory practices challenges many toxicologists, clinical laboratories, and pharmaceutical scientists. The Handbook of Analytical Therapeutic Drug Monitoring and Toxicology helps you keep abreast of the innovative changes that can make your laboratory - and the studies undertaken in it - a success. This volume simplifies your search for appropriate techniques, describes recent contributions from leading investigators, and provides valuable evaluations and advice.

Clinical Challenges in Therapeutic Drug Monitoring

Clinical Challenges in Therapeutic Drug Monitoring
Author: William Clarke,Amitava Dasgupta
Publsiher: Elsevier
Total Pages: 376
Release: 2016-07-21
ISBN 10: 0128020520
ISBN 13: 9780128020524
Language: EN, FR, DE, ES & NL

Clinical Challenges in Therapeutic Drug Monitoring Book Review:

Clinical Challenges in Therapeutic Drug Monitoring: Special Populations, Physiological Conditions and Pharmacogenomics focuses on critical issues in therapeutic drug monitoring including special requirements of therapeutic drug monitoring important to special populations (infants and children, pregnant women, elderly patients, and obese patients). The book also covers issues of free drug monitoring and common interferences in using immunoassays for therapeutic drug monitoring. This book is essential reading for any clinician, fellow, or trainee who wants to gain greater insight into the process of therapeutic drug monitoring for individual dosage adjustment and avoiding drug toxicity for certain drugs within a narrow therapeutic window. The book is written specifically for busy clinicians, fellows, and trainees who order therapeutic drug monitoring and need to get more familiar with testing methodologies, issues of interferences, and interpretation of results in certain patient populations. Offers busy clinicians, pathologists, and trainees a concise resource on the key aspects and critical issues in therapeutic drug monitoring Focuses on patient populations such as infants and children, pregnant women, elderly patients, and obese patients, who have special requirements in therapeutic drug monitoring Explores special topics in therapeutic drug monitoring including free drug monitoring and common immunoassay interference Explains how individual dosage adjustments can prevent drug toxicity for certain drugs within a narrow therapeutic window

Pharmacogenetics Kinetics and Dynamics for Personalized Medicine

Pharmacogenetics  Kinetics  and Dynamics for Personalized Medicine
Author: David F. Kisor,Professor of Pharmacokinetics Chair Department of Pharmaceutical and Biomedical Sciences Ohio Northern University Raabe College of Pharmacy David F Kisor,Michael D. Kane,Jon E. Sprague,Jeffery N. Talbot
Publsiher: Jones & Bartlett Publishers
Total Pages: 330
Release: 2013-02-01
ISBN 10: 1449633943
ISBN 13: 9781449633943
Language: EN, FR, DE, ES & NL

Pharmacogenetics Kinetics and Dynamics for Personalized Medicine Book Review:

Pharmacogenetics, Kinetics, and Dynamics for Personalized Medicine provides a primer to understand pharmacogenetics (the study of genetic factors that influence how a drug works) in the applied context of pharmacokinetics (how the body handles a drug) and pharmacodynamics (the effects of a drug on the body). This valuable foundation illuminates how these principles and scientific advances can create optimal individual patient care, that is, personalized medicine. Through specific drug examples, this resource explores how the genetic constitution of an individual may lead to the need for an altered dose or in some cases alternative drug therapy. Real-world cases highlight the specific relationships between genetics, drug action, and the body s response as well as adverse drug reactions, altered metabolism, and drug efficacy. Ethical issues concerning pharmacogenomics and study design are also discussed in this concise overview."

Clinical Chemistry Immunology and Laboratory Quality Control

Clinical Chemistry  Immunology and Laboratory Quality Control
Author: Amitava Dasgupta,Amer Wahed
Publsiher: Academic Press
Total Pages: 504
Release: 2013-12-02
ISBN 10: 0124079350
ISBN 13: 9780124079359
Language: EN, FR, DE, ES & NL

Clinical Chemistry Immunology and Laboratory Quality Control Book Review:

All pathology residents must have a good command of clinical chemistry, toxicology, immunology, and laboratory statistics to be successful pathologists, as well as to pass the American Board of Pathology examination. Clinical chemistry, however, is a topic in which many senior medical students and pathology residents face challenges. Clinical Chemistry, Immunology and Laboratory Quality Control meets this challenge head on with a clear and easy-to-read presentation of core topics and detailed case studies that illustrate the application of clinical chemistry knowledge to everyday patient care. This basic primer offers practical examples of how things function in the pathology clinic as well as useful lists, sample questions, and a bullet-point format ideal for quick pre-Board review. While larger textbooks in clinical chemistry provide highly detailed information regarding instrumentation and statistics, this may be too much information for students, residents, and clinicians. This book is designed to educate senior medical students, residents, and fellows, and to "refresh" the knowledge base of practicing clinicians on how tests are performed in their laboratories (i.e., method principles, interferences, and limitations). Takes a practical and easy-to-read approach to understanding clinical chemistry and toxicology Covers all important clinical information found in larger textbooks in a more succinct and easy-to-understand manner Covers essential concepts in instrumentation and statistics in such a way that fellows and clinicians understand the methods without having to become specialists in the field Includes chapters on drug-herb interaction and pharmacogenomics, topics not covered by textbooks in the field of clinical chemistry or laboratory medicine

Individualized Drug Therapy for Patients

Individualized Drug Therapy for Patients
Author: Roger W Jelliffe,Michael Neely
Publsiher: Academic Press
Total Pages: 434
Release: 2016-11-15
ISBN 10: 0128033495
ISBN 13: 9780128033494
Language: EN, FR, DE, ES & NL

Individualized Drug Therapy for Patients Book Review:

Individualized Drug Therapy for Patients: Basic Foundations, Relevant Software and Clinical Applications focuses on quantitative approaches that maximize the precision with which dosage regimens of potentially toxic drugs can hit a desired therapeutic goal. This book highlights the best methods that enable individualized drug therapy and provides specific examples on how to incorporate these approaches using software that has been developed for this purpose. The book discusses where individualized therapy is currently and offers insights to the future. Edited by Roger Jelliffe, MD and Michael Neely, MD, renowned authorities in individualized drug therapy, and with chapters written by international experts, this book provides clinical pharmacologists, pharmacists, and physicians with a valuable and practical resource that takes drug therapy away from a memorized ritual to a thoughtful quantitative process aimed at optimizing therapy for each individual patient. Uses pharmacokinetic approaches as the tools with which therapy is individualized Provides examples using specific software that illustrate how best to apply these approaches and to make sense of the more sophisticated mathematical foundations upon which this book is based Incorporates clinical cases throughout to illustrate the real-world benefits of using these approaches Focuses on quantitative approaches that maximize the precision with which dosage regimens of potentially toxic drugs can hit a desired therapeutic goal

Therapeutic Drug Monitoring and Laboratory Medicine

Therapeutic Drug Monitoring and Laboratory Medicine
Author: Mike Hallworth,Ian D. Watson,Karen H. Poyser,Roy A. Sherwood
Publsiher: Unknown
Total Pages: 218
Release: 2008
ISBN 10: 9780902429420
ISBN 13: 0902429426
Language: EN, FR, DE, ES & NL

Therapeutic Drug Monitoring and Laboratory Medicine Book Review:

Antidepressants Past Present and Future

Antidepressants  Past  Present and Future
Author: Sheldon H. Preskorn,Christina Y. Stanga,John P. Feighner,Ruth Ross
Publsiher: Springer Science & Business Media
Total Pages: 615
Release: 2012-12-06
ISBN 10: 3642185002
ISBN 13: 9783642185007
Language: EN, FR, DE, ES & NL

Antidepressants Past Present and Future Book Review:

A comprehensive review of the current status of antidepressants - how we arrived at this point in their evolution and where we are going in both the near and the long term. It employs both a scientific and historical approach to accomplish these goals. This volume is intended for practitioners who use antidepressants on a daily basis in their practice as well as for the student and researcher. Each will find that it provides a comprehensive and logical approach to this important group of medications. This book is being published as we mark the end of the first 50 years of the modern antidepressant era.

Alcohol Drugs Genes and the Clinical Laboratory

Alcohol  Drugs  Genes and the Clinical Laboratory
Author: Amitava Dasgupta
Publsiher: Academic Press
Total Pages: 236
Release: 2016-10-17
ISBN 10: 012809334X
ISBN 13: 9780128093344
Language: EN, FR, DE, ES & NL

Alcohol Drugs Genes and the Clinical Laboratory Book Review:

Alcohol, Drugs, Genes and the Clinical Laboratory provides an overview and quick reference to genetic relationships and clinical laboratory information related to the serious public health issue of alcohol and drug abuse. Written in a clear and concise manner, this book discusses the necessary information for health and safety professionals working in public health to learn about complex issues quickly to better help their patients, employees, and others affected by alcohol and drug abuse. Alcohol, Drugs, Genes and the Clinical Laboratory covers the important aspects of drugs and alcohol abuse including genetic aspects along with laboratory methods for analysis of alcohol and abused drugs with emphasis on false positive test results. The book is helpful to healthcare professionals, such as pathologists who oversee alcohol and drug testing, emergency room physicians, family practice physicians who are first healthcare professionals who identify patients susceptible to drug and alcohol abuse, and psychiatrists involved with drug and alcohol rehabilitation programs. It will also be useful to safety professionals who have to assess individuals for workplace responsibilities, ranging from police and recruitment to occupational safety and occupational medicine and public health officials. Features accessible language for healthcare and safety professionals who are not experts in laboratory procedures Provides examples from clinical and everyday situations Explains how to interpret laboratory results and the latest genetic factors regarding drug and alcohol abuse

Pharmacovigilance in Psychiatry

Pharmacovigilance in Psychiatry
Author: Edoardo Spina,Gianluca Trifirò
Publsiher: Springer
Total Pages: 319
Release: 2015-12-07
ISBN 10: 3319247417
ISBN 13: 9783319247410
Language: EN, FR, DE, ES & NL

Pharmacovigilance in Psychiatry Book Review:

The first authoritative textbook specifically addressing issues of the field, this book delivers a focused discussion on several themes in psychiatry while providing a sound background on pharmacovigilance. Internationally-recognised researchers, clinicians and pharmacovigilance experts contributed to this textbook, giving it the benefit of different perspectives and years of experience. Pharmacovigilance in psychiatry provides a thorough introduction to this field but goes on to explore advanced themes such as methodologies and resources used for pharmacovigilance in psychiatry, challenges as well as most recent developments to this field, making it suitable for under-graduates, graduate and post-doctoral students and persons working pharmacovigilance who seek to broaden their knowledge on this subject.

Quality Assurance in the Pathology Laboratory

Quality Assurance in the Pathology Laboratory
Author: Maciej J. Bogusz
Publsiher: CRC Press
Total Pages: 388
Release: 2011-02-22
ISBN 10: 1439802351
ISBN 13: 9781439802359
Language: EN, FR, DE, ES & NL

Quality Assurance in the Pathology Laboratory Book Review:

Quality refers to the amount of the unpriced attributes contained in each unit of the priced attribute.Leffler, 1982Quality is neither mind nor matter, but a third entity independent of the two, even though Quality cannot be defined, you know what it is.Pirsig, 2000The continuous formulation of good practices and procedures across fields reflects t

IBD Management Novel Targets and Therapeutic Perspectives

IBD Management   Novel Targets and Therapeutic Perspectives
Author: Luca Antonioli,Barbara Romano,Corrado Blandizzi,Matteo Fornai
Publsiher: Frontiers Media SA
Total Pages: 329
Release: 2020-05-28
ISBN 10: 2889637719
ISBN 13: 9782889637713
Language: EN, FR, DE, ES & NL

IBD Management Novel Targets and Therapeutic Perspectives Book Review:

Contemporary Practice in Clinical Chemistry

Contemporary Practice in Clinical Chemistry
Author: William Clarke,Mark Marzinke
Publsiher: Academic Press
Total Pages: 1064
Release: 2020-06-11
ISBN 10: 0128158336
ISBN 13: 9780128158333
Language: EN, FR, DE, ES & NL

Contemporary Practice in Clinical Chemistry Book Review:

Contemporary Practice in Clinical Chemistry, Fourth Edition, provides a clear and concise overview of important topics in the field. This new edition is useful for students, residents and fellows in clinical chemistry and pathology, presenting an introduction and overview of the field to assist readers as they in review and prepare for board certification examinations. For new medical technologists, the book provides context for understanding the clinical utility of tests that they perform or use in other areas in the clinical laboratory. For experienced laboratorians, this revision continues to provide an opportunity for exposure to more recent trends and developments in clinical chemistry. Includes enhanced illustration and new and revised color figures Provides improved self-assessment questions and end-of-chapter assessment questions