Metabolomics for Biomedical Research

Metabolomics for Biomedical Research
Author: Jerzy Adamski
Publsiher: Academic Press
Total Pages: 300
Release: 2020-04
ISBN 10: 0128127848
ISBN 13: 9780128127841
Language: EN, FR, DE, ES & NL

Metabolomics for Biomedical Research Book Review:

Metabolomics for Biomedical Research brings together recent progress on study design, analytics, biostatistics and bioinformatics for the success of metabolomics research. Metabolomics represents a very interdisciplinary research prominent in the functional analyses of living systems; hence, this book focuses on translation and medical aspects. The book discusses topics such as biomarkers and their requirements to be used in medical research, with the parameters and approaches on how to validate their quality; and animal models and other approaches, as stem cells and organoid culture. Additionally, it explains how metabolomics may be applied in prediction of individual response to drug or disease progression. This book is a valuable source for researchers on systems biology and other members of biomedical field interested in metabolism-oriented studies for medical research.

Metabolomics as a Tool in Nutrition Research

Metabolomics as a Tool in Nutrition Research
Author: J-L Sebedio,L Brennan
Publsiher: Elsevier
Total Pages: 268
Release: 2014-11-28
ISBN 10: 1782420924
ISBN 13: 9781782420927
Language: EN, FR, DE, ES & NL

Metabolomics as a Tool in Nutrition Research Book Review:

Metabolomics is a multidisciplinary science used to understand the ways in which nutrients from food are used in the body and how this can be optimised and targeted at specific nutritional needs. Metabolomics as a Tool in Nutrition Research provides a review of the uses of metabolomics in nutritional research. Chapters cover the most important aspects of the topic such as analysis techniques, bioinformatics and integration with other ‘omic’ sciences such as proteomics and genomics. The final chapters look at the impact of exercise on metabolomic profiles and future trends in metabolomics for nutrition research.

Advancements of Mass Spectrometry in Biomedical Research

Advancements of Mass Spectrometry in Biomedical Research
Author: Alisa G. Woods,Costel C. Darie
Publsiher: Springer
Total Pages: 600
Release: 2014-06-20
ISBN 10: 3319060686
ISBN 13: 9783319060682
Language: EN, FR, DE, ES & NL

Advancements of Mass Spectrometry in Biomedical Research Book Review:

This volume explores the use of mass spectrometry for biomedical applications. Chapters focus on specific therapeutic areas such as oncology, infectious disease and psychiatry. Additional chapters focus on methodology as well as new technologies and instrumentation. This volume provides readers with a comprehensive and informative manual that will allow them to appreciate mass spectrometry and proteomic research but also to initiate and improve their own work. Thus the book acts as a technical guide but also a conceptual guide to the newest information in this exciting field. Mass spectrometry is the central tool used in proteomic research today and is rapidly becoming indispensable to the biomedical scientist. With the completion of the human genome project and the genomic revolution, the proteomic revolution has followed closely behind. Understanding the human proteome has become critical to basic and clinical biomedical research and holds the promise of providing comprehensive understanding of human physiological processes. In addition, proteomics and mass spectrometry are bringing unprecedented biomarker discovery and are helping to personalize medicine.

Advancements of Mass Spectrometry in Biomedical Research

Advancements of Mass Spectrometry in Biomedical Research
Author: Alisa G. Woods,Costel C. Darie
Publsiher: Springer
Total Pages: 813
Release: 2019-07-25
ISBN 10: 3030159507
ISBN 13: 9783030159504
Language: EN, FR, DE, ES & NL

Advancements of Mass Spectrometry in Biomedical Research Book Review:

This volume explores the use of mass spectrometry for biomedical applications. Chapters focus on specific therapeutic areas such as oncology, infectious disease, and psychiatry. Additional chapters focus on methodology, technologies and instrumentation, as well as on analysis of protein-protein interactions, protein quantitation, and protein post-translational modifications. Various omics fields such as proteomics, metabolomics, glycomics, lipidomics, and adductomics are also covered. Applications of mass spectrometry in biotechnological and pharmaceutical industry are also discussed. This volume provides readers with a comprehensive and informative manual that will allow them to appreciate mass spectrometry and proteomic research, but also to initiate and improve their own work. This book acts as a technical guide as well as a conceptual guide to the newest information in this exciting field.

Advances in Gas Chromatography

Advances in Gas Chromatography
Author: Xinghua Guo
Publsiher: BoD – Books on Demand
Total Pages: 224
Release: 2014-02-26
ISBN 10: 9535112279
ISBN 13: 9789535112273
Language: EN, FR, DE, ES & NL

Advances in Gas Chromatography Book Review:

For decades gas chromatography has been and will remain an irreplaceable analytical technique in many research areas for both quantitative analysis and qualitative characterization/identification, which is still supplementary with HPLC. This book highlights a few areas where significant advances have been reported recently and/or a revisit of basic concepts is deserved. It provides an overview of instrumental developments, frontline and modern research as well as practical industrial applications. The topics include GC-based metabolomics in biomedical, plant and microbial research, natural products as well as characterization of aging of synthetic materials and industrial monitoring, which are contributions of several experts from different disciplines. It also contains best hand-on practices of sample preparation (derivatization) and data processing in daily research. This book is recommended to both basic and experienced researchers in gas chromatography.

High Throughput Metabolomics

High Throughput Metabolomics
Author: Angelo D'Alessandro
Publsiher: Humana
Total Pages: 459
Release: 2020-06-06
ISBN 10: 9781493992386
ISBN 13: 1493992384
Language: EN, FR, DE, ES & NL

High Throughput Metabolomics Book Review:

This detailed volume focuses on recent technological, computational, and biostatistical advances in the field of high-throughput metabolomics. Chapters encompass methods, platforms, and analytical strategies for steady state measurements and metabolic flux analysis with stable isotope-labeled tracers, in biological matrices of clinical relevance and model organisms. Mass spectrometry-based or orthogonal methods are discussed, along with computational and statistical methods to address data sparsity in high-throughput metabolomics approaches. As a part of the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, High-Throughput Metabolomics: Methods and Protocols provides tools that can bring about the next generation of clinical biochemistry in a cost-effective, rigorous fashion, exponentially advancing our capacity to investigate nature while hastening the advent of personalized medicine.

Genomics Proteomics and Metabolomics

Genomics  Proteomics  and Metabolomics
Author: Babak Arjmand
Publsiher: Springer Nature
Total Pages: 199
Release: 2019-11-14
ISBN 10: 3030277275
ISBN 13: 9783030277277
Language: EN, FR, DE, ES & NL

Genomics Proteomics and Metabolomics Book Review:

This book provides thorough coverage of high-throughput OMICs technologies for the monitoring of stem cells and regenerative medicine. Specific topics covered include the genomics, proteomics, and metabolomics aspects of regenerative medicine, metabolic profiling of mesenchymal stem cells, genome profiling of mesenchymal stem cells, OMICs monitoring of stem cell-derived exosomes, stem cell proteomics, lipidomics, OMICs profiling of cancer (stem) cells, and finally ethical considerations of OMICs-based investigations. Chapters are authored by world-renowned scientists who have valuable expertise in the field of OMICs and regenerative medicine. Genomics, Proteomics, and Metabolomics: Stem Cells Monitoring in Regenerative Medicine, part of Springer’s Stem Cell Biology and Regenerative Medicine series, is essential reading for researchers, clinicians, biologists, biochemists, and pharmaceutical experts conducting research in the fields of stem cell biology, molecular aspects of stem cell research, tissue engineering, regenerative medicine, cellular therapy, OMICs, bioinformatics, and ethics.

Mass Spectrometry Based Metabolomics

Mass Spectrometry Based Metabolomics
Author: Sastia Prama Putri,Eiichiro Fukusaki
Publsiher: CRC Press
Total Pages: 294
Release: 2016-04-21
ISBN 10: 1482223775
ISBN 13: 9781482223774
Language: EN, FR, DE, ES & NL

Mass Spectrometry Based Metabolomics Book Review:

Mass Spectrometry-Based Metabolomics: A Practical Guide is a simple, step-by-step reference for profiling metabolites in a target organism. It discusses optimization of sample preparation for urine, serum, blood, tissue, food, and plant and animal cell samples. Encompassing three different technical fields—biology, analytical chemistry, and informatics— mass spectrometry-based metabolomics can be challenging for biologists without special training in quantitative mass spectrometry. This book is designed to overcome this limitation by providing researchers with the knowledge they need to use metabolomics technology in their respective disciplines. The book summarizes all steps in metabolomics research, from experimental design to sample preparation, analytical procedures, and data analysis. Case studies are presented for easy understanding of the metabolomics workflow and its practical applications in different research fields. The book includes an in-house library and built-in software so that those new to the field can begin to analyze real data samples. In addition to being an excellent introductory text, the book also contains the latest advancements in this emerging field and can thus be a useful reference for metabolomics specialists.

Methodologies for Metabolomics

Methodologies for Metabolomics
Author: Norbert W. Lutz,Jonathan V. Sweedler,Ron A. Wevers
Publsiher: Cambridge University Press
Total Pages: 329
Release: 2013-01-21
ISBN 10: 1139619055
ISBN 13: 9781139619059
Language: EN, FR, DE, ES & NL

Methodologies for Metabolomics Book Review:

Metabolomics, the global characterisation of the small molecule complement involved in metabolism, has evolved into a powerful suite of approaches for understanding the global physiological and pathological processes occurring in biological organisms. The diversity of metabolites, the wide range of metabolic pathways and their divergent biological contexts require a range of methodological strategies and techniques. Methodologies for Metabolomics provides a comprehensive description of the newest methodological approaches in metabolomic research. The most important technologies used to identify and quantify metabolites, including nuclear magnetic resonance and mass spectrometry, are highlighted. The integration of these techniques with classical biological methods is also addressed. Furthermore, the book presents statistical and chemometric methods for evaluation of the resultant data. The broad spectrum of topics includes a vast variety of organisms, samples and diseases, ranging from in vivo metabolomics in humans and animals to in vitro analysis of tissue samples, cultured cells and biofluids.

Toward Precision Medicine

Toward Precision Medicine
Author: National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on A Framework for Developing a New Taxonomy of Disease
Publsiher: National Academies Press
Total Pages: 142
Release: 2012-01-16
ISBN 10: 0309222222
ISBN 13: 9780309222228
Language: EN, FR, DE, ES & NL

Toward Precision Medicine Book Review:

Motivated by the explosion of molecular data on humans-particularly data associated with individual patients-and the sense that there are large, as-yet-untapped opportunities to use this data to improve health outcomes, Toward Precision Medicine explores the feasibility and need for "a new taxonomy of human disease based on molecular biology" and develops a potential framework for creating one. The book says that a new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of diseases and ultimately enhance diagnosis and treatment. The "new taxonomy" that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms. The book adds that the new data network could also improve biomedical research by enabling scientists to access patients' information during treatment while still protecting their rights. This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia. Toward Precision Medicine notes that moving toward individualized medicine requires that researchers and health care providers have access to very large sets of health- and disease-related data linked to individual patients. These data are also critical for developing the information commons, the knowledge network of disease, and ultimately the new taxonomy.

Volatile Organic Compound Analysis in Biomedical Diagnosis Applications

Volatile Organic Compound Analysis in Biomedical Diagnosis Applications
Author: Raquel Cumeras,Xavier Correig
Publsiher: CRC Press
Total Pages: 272
Release: 2018-11-22
ISBN 10: 042978242X
ISBN 13: 9780429782428
Language: EN, FR, DE, ES & NL

Volatile Organic Compound Analysis in Biomedical Diagnosis Applications Book Review:

This volume presents a thought-provoking state-of-the-art picture of how volatile compounds are used in metabolomics, currently a hot topic in the metabolomics field. It provides a thorough description of what volatile organic compounds (VOCs) are, why they are important in biomedicine, and what the analytical platforms are used. It also looks at multivariate analysis and databases needs. Because VOCs are end-up compounds of metabolic processes, volatiles can be linked to different diseases or pathologies for both diagnosis and prognosis. The authors provide authoritative information and guidance on the analytical and statistical techniques used and how to identify, and they review the main current areas of application, which include breath metabolomics, cancer diagnosis, and microbial volatiles. Key Features: Presents a thorough overview of volatile research in biomedical applications Examines both gold standard techniques (metabolomics based) and artificial olfactory systems Reviews all aspects of volatile metabolites in biomedicine research, from origin to detection platforms Describes relevant diseases diagnosis and prognosis achievements, including cancer

Metabolomics

Metabolomics
Author: M. Tomita,T. Nishioka
Publsiher: Springer Science & Business Media
Total Pages: 256
Release: 2006-06-18
ISBN 10: 4431280553
ISBN 13: 9784431280552
Language: EN, FR, DE, ES & NL

Metabolomics Book Review:

Metabolism is the sum of the chemical reactions in cells that produce life-sustaining chemical energy and metabolites. In the post-genome era, metabolism has taken on new significance for biological scientists: metabolites are the chemical basis of phenotypes that are final expressions of genomic information. This book covers research on metabolomics, ranging from the development of specialized chemical analytical techniques to the construction of databases and methods for metabolic simulation. The authors have been directly involved in the development of all the subject areas, including capillary electrophoresis, liquid chromatography, mass spectrometry, metabolic databases, and metabolic simulation. Breakthrough achievements and the future of metabolome studies are described, making this book a valuable source for researchers in metabolomics in diverse fields, such as plant, animal, cellular, microbial, pharmaceutical, medical, and genetic sciences.

Genetics Meets Metabolomics

Genetics Meets Metabolomics
Author: Karsten Suhre
Publsiher: Springer Science & Business Media
Total Pages: 318
Release: 2012-06-15
ISBN 10: 1461416892
ISBN 13: 9781461416890
Language: EN, FR, DE, ES & NL

Genetics Meets Metabolomics Book Review:

This book is written by leading researchers in the fields about the intersection of genetics and metabolomics which can lead to more comprehensive studies of inborn variation of metabolism.

OMICS

OMICS
Author: Debmalya Barh,Vasudeo Zambare,Vasco Azevedo
Publsiher: CRC Press
Total Pages: 713
Release: 2013-03-26
ISBN 10: 1466562811
ISBN 13: 9781466562813
Language: EN, FR, DE, ES & NL

OMICS Book Review:

With the advent of new technologies and acquired knowledge, the number of fields in omics and their applications in diverse areas are rapidly increasing in the postgenomics era. Such emerging fields—including pharmacogenomics, toxicogenomics, regulomics, spliceomics, metagenomics, and environomics—present budding solutions to combat global challenges in biomedicine, agriculture, and the environment. OMICS: Applications in Biomedical, Agricultural, and Environmental Sciences provides valuable insights into the applications of modern omics technologies to real-world problems in the life sciences. Filling a gap in the literature, it offers a broad, multidisciplinary view of current and emerging applications of omics in a single volume. Written by highly experienced active researchers, each chapter describes a particular area of omics and the associated technologies and applications. Topics covered include: Proteomics, epigenomics, and pharmacogenomics Toxicogenomics and the assessment of environmental pollutants Applications of plant metabolomics Nutrigenomics and its therapeutic applications Microalgal omics and omics approaches in biofuel production Next-generation sequencing and omics technology for transgenic plant analysis Omics approaches in crop improvement Engineering dark-operative chlorophyll synthesis Computational regulomics Omics techniques for the analysis of RNA splicing New fields, including metagenomics, glycomics, and miRNA Breast cancer biomarkers for early detection Environomics strategies for environmental sustainability This timely book explores a wide range of omics application areas in the biomedical, agricultural, and environmental sciences. Throughout, it highlights working solutions as well as open problems and future challenges. Demonstrating the diversity of omics, it introduces readers to state-of-the-art developments and trends in omics-driven research.

OMICS

OMICS
Author: Debmalya Barh,Kenneth Blum,Margaret A. Madigan
Publsiher: CRC Press
Total Pages: 622
Release: 2016-04-19
ISBN 10: 1439850097
ISBN 13: 9781439850091
Language: EN, FR, DE, ES & NL

OMICS Book Review:

A reflection of the explosion of research and development in this field, OMICS: Biomedical Perspectives and Applications explores applications of omics in bioinformatics, cancer research and therapy, diabetes research, plant science, molecular biology, and neurosciences. A select editorial panel of experts discusses their cutting edge omics research and novel technologies, supplying a basic platform of methods and applications and a resource for enhanced cross-pollination in a multiomics approach to future endeavors in the fertile fields of omics research. After an introduction on the omics universe, the book presents modern omics and its applications in nanotechnology, genomics, proteomics, metagenomics, toxicogenomics, immunomics, nutrigenomics, diabetes, neurology, cardiology, and cancer to name just a few. The book begins with an overview of omics and omic technologies such as cellomics, glycomics, and lipidomics. It also discusses bioinformatics, demonstrating how it can be a tool in omics, and examines the various approaches of omics technology in toxicology research and applications in biomedical sciences. While there are a long list of omics books available, most focus narrowly on one area. Presenting a wide view of the current status of integrative omics, this resource contains complete coverage of omics in research and therapy, ranging from neuroscience to cardiology. It collates recent developments in the field into a state-of-the-art framework for this discipline.

Molecular Diagnostics Promises and Possibilities

Molecular Diagnostics  Promises and Possibilities
Author: Mousumi Debnath,Godavarthi B.K.S. Prasad,Prakash S. Bisen
Publsiher: Springer Science & Business Media
Total Pages: 520
Release: 2010-01-29
ISBN 10: 9789048132614
ISBN 13: 9048132614
Language: EN, FR, DE, ES & NL

Molecular Diagnostics Promises and Possibilities Book Review:

A rapid development in diverse areas of molecular biology and genetic engineering resulted in emergence of variety of tools. These tools are not only applicable to basic researches being carried out world over, but also exploited for precise detection of abnormal conditions in plants, animals and human body. Although a basic researcher is well versed with few techniques used by him/her in the laboratory, they may not be well acquainted with methodologies, which can be used to work out some of their own research problems. The picture is more blurred when the molecular diagnostic tools are to be used by physicians, scientists and technicians working in diagnostic laboratories in hospitals, industry and academic institutions. Since many of them are not trained in basics of these methods, they come across several gray areas in understanding of these tools. The accurate application of molecular diagnostic tools demands in depth understanding of the methodology for precise detection of the abnormal condition of living body. To meet the requirements of a good book on molecular diagnostics of students, physicians, scientists working in agricultural, veterinary, medical and pharmaceutical sciences, it needs to expose the reader lucidly to: Give basic science behind commonly used tools in diagnostics Expose the readers to detailed applications of these tools and Make them aware the availability of such diagnostic tools The book will attract additional audience of pathologists, medical microbiologists, pharmaceutical sciences, agricultural scientists and veterinary doctors if the following topics are incorporated at appropriate places in Unit II or separately as a part of Unit-III in the book. Molecular diagnosis of diseases in agricultural crops Molecular diagnosis of veterinary diseases. Molecular epidemiology, which helps to differentiate various epidemic strains and sources of disease outbreaks. Even in different units of the same hospital, the infections could be by different strains of the same species and the information becomes valuable for infection control strategies. Drug resistance is a growing problem for bacterial, fungal and parasitic microbes and the molecular biology tools can help to detect the drug resistance genes without the cultivation and in vitro sensitivity testing. Molecular diagnostics offers faster help in the selection of the proper antibiotic for the treatment of tuberculosis, which is a major problem of the in the developing world. The conventional culture and drug sensitivity testing of tuberculosis bacilli is laborious and time consuming, whereas molecular diagnosis offers rapid drug resistant gene detection even from direct clinical samples. The same approach for HIV, malaria and many more diseases needs to be considered. Molecular diagnostics in the detection of diseases during foetal life is an upcoming area in the foetal medicine in case of genetic abnormalities and infectious like TORCH complex etc. The book will be equally useful to students, scientists and professionals working in the field of molecular diagnostics.

The Minipig in Biomedical Research

The Minipig in Biomedical Research
Author: Peter A. McAnulty,Anthony D. Dayan,Niels-Christian Ganderup,Kenneth L. Hastings
Publsiher: CRC Press
Total Pages: 662
Release: 2011-12-19
ISBN 10: 1439811180
ISBN 13: 9781439811184
Language: EN, FR, DE, ES & NL

The Minipig in Biomedical Research Book Review:

The Minipig in Biomedical Research is a comprehensive resource for research scientists on the potential and use of the minipig in basic and applied biomedical research, and the development of drugs and chemicals. Written by acknowledged experts in the field, and drawing on the authors’ global contacts and experience with regulatory authorities and the pharmaceutical and other industries, this accessible manual ranges widely over the biological, scientific, and practical uses of the minipig in the laboratory. Its coverage extends from the minipig’s origins, anatomy, genetics, immunology, and physiology to its welfare, health, and husbandry; practical dosing and examination procedures; surgical techniques; and all areas of toxicity testing and the uses of the minipig as a disease model. Regulatory aspects of its use are considered. The reader will find an extensive amount of theoretical and practical information in the pharmacology; ADME and toxicology chapters which will help scientists and managers when deciding which species to use in basic research; drug discovery and pharmacology; and toxicology studies of chemicals, biotechnology products and devices. The book discusses regulatory uses of minipigs in the evaluation of human and veterinary pharmaceuticals, medical devices, and other classes of xenobiotics. It describes features of normal health, normal laboratory values, and common diseases. It also carefully elucidates ethical and legal considerations in their supply, housing, and transport. The result is an all-inclusive and up to date manual about the experimental uses of the minipig that describes ‘How to’ and ‘Why’ and ’What to expect in the normal’, combining enthusiasm and experience with critical assessment of its values and potential problems.

Metabolomics Metabonomics and Metabolite Profiling

Metabolomics  Metabonomics and Metabolite Profiling
Author: William J. Griffiths
Publsiher: Royal Society of Chemistry
Total Pages: 323
Release: 2008
ISBN 10: 0854042997
ISBN 13: 9780854042999
Language: EN, FR, DE, ES & NL

Metabolomics Metabonomics and Metabolite Profiling Book Review:

In this comprehensive resource the Editor draws together experts from the field and provides an insightful introduction into the technology and methodology.

Data Analysis for Omic Sciences Methods and Applications

Data Analysis for Omic Sciences  Methods and Applications
Author: Anonim
Publsiher: Elsevier
Total Pages: 730
Release: 2018-09-22
ISBN 10: 0444640452
ISBN 13: 9780444640451
Language: EN, FR, DE, ES & NL

Data Analysis for Omic Sciences Methods and Applications Book Review:

Data Analysis for Omic Sciences: Methods and Applications, Volume 82, shows how these types of challenging datasets can be analyzed. Examples of applications in real environmental, clinical and food analysis cases help readers disseminate these approaches. Chapters of note include an Introduction to Data Analysis Relevance in the Omics Era, Omics Experimental Design and Data Acquisition, Microarrays Data, Analysis of High-Throughput RNA Sequencing Data, Analysis of High-Throughput DNA Bisulfite Sequencing Data, Data Quality Assessment in Untargeted LC-MS Metabolomic, Data Normalization and Scaling, Metabolomics Data Preprocessing, and more. Presents the best reference book for omics data analysis Provides a review of the latest trends in transcriptomics and metabolomics data analysis tools Includes examples of applications in research fields, such as environmental, biomedical and food analysis

Metabolomics From Fundamentals to Clinical Applications

Metabolomics  From Fundamentals to Clinical Applications
Author: Alessandra Sussulini
Publsiher: Springer
Total Pages: 350
Release: 2017-01-28
ISBN 10: 3319476564
ISBN 13: 9783319476568
Language: EN, FR, DE, ES & NL

Metabolomics From Fundamentals to Clinical Applications Book Review:

This book provides a comprehensive view of metabolomics, from the basic concepts, through sample preparation and analytical methodologies, to data interpretation and applications in medicine. It is the first volume to cover metabolomics clinical applications while also emphasizing analytical and statistical features. Moreover, future trends and perspectives in clinical metabolomics are also presented. For researches already experienced in metabolomics, the book will be useful as an updated definitive reference. For beginners in the field and graduate students, the book will provide detailed information about concepts and experimental aspects in metabolomics, as well as examples and perspectives of applications of this strategy to clinical questions.