Mesenchymal Stem Cells and Skeletal Regeneration

Mesenchymal Stem Cells and Skeletal Regeneration
Author: Peter Giannoudis,Elena Jones,Xuebin Yang,Dennis Mcgonagle
Publsiher: Academic Press
Total Pages: 70
Release: 2013-02-20
ISBN 10: 0124081312
ISBN 13: 9780124081314
Language: EN, FR, DE, ES & NL

Mesenchymal Stem Cells and Skeletal Regeneration Book Review:

This book covers our current understanding of the role of mesenchymal stem cells (MSCs) and other mesenchymal progenitors in skeletal regeneration, encompassing bone, cartilage and whole joint regeneration. The expansion reflects developments in the field to include data on the use of MSCs in drug development, growth factors, scaffolds and biomechanical manipulations for skeletal trauma and diseases, including osteoporosis and arthritis. Written for an audience of clinicians and young researchers who are exposed to MSCs in their work, this work summarizes recent findings pertaining to the definition and characterization of MSCs in skeletal tissues and discusses the mechanisms of their actions in regeneration of bone in vivo. The authors describe recent findings pertaining to the efficacy of MSC therapies in animal models and in human clinical trials and bring together literature showing that the ways MSCs are extracted, expanded and implanted can considerably affect bone formation outcomes. Finally, it presents the latest knowledge on the nature of native MSCs in skeletal tissues, which provide a platform for novel in situ tissue regeneration approaches for systemic bone disease such as osteoporosis. Focuses specifically on the use of stem cells in skeletal tissue generation for a broad audience of stem cell, cancer, and bone biologists, orthopedists, oncologists, and regenerative medicine specialists Provides a short historical ‘detour’ and foundational information on founding concepts, discoveries and personalities in MSC research Assists a new generation of scientists and clinicians in digesting the multitude of journal articles on the topic by providing easily-absorbed and condensed foundational context

Mesenchymal Stem Cells and Skeletal Regeneration

Mesenchymal Stem Cells and Skeletal Regeneration
Author: Elena Jones
Publsiher: Unknown
Total Pages: 135
Release: 2013
ISBN 10: 1928374650XXX
ISBN 13: OCLC:1281875497
Language: EN, FR, DE, ES & NL

Mesenchymal Stem Cells and Skeletal Regeneration Book Review:

This book covers our current understanding of the role of mesenchymal stem cells (MSCs) and other mesenchymal progenitors in skeletal regeneration, encompassing bone, cartilage and whole joint regeneration. The expansion reflects developments in the field to include data on the use of MSCs in drug development, growth factors, scaffolds and biomechanical manipulations for skeletal trauma and diseases, including osteoporosis and arthritis. Written for an audience of clinicians and young researchers who are exposed to MSCs in their work, this work summarizes recent findings pertaining to the definition and characterization of MSCs in skeletal tissues and discusses the mechanisms of their actions in regeneration of bone in vivo. The authors describe recent findings pertaining to the efficacy of MSC therapies in animal models and in human clinical trials and bring together literature showing that the ways MSCs are extracted, expanded and implanted can considerably affect bone formation outcomes. Finally, it presents the latest knowledge on the nature of native MSCs in skeletal tissues, which provide a platform for novel in situ tissue regeneration approaches for systemic bone disease such as osteoporosis. Focuses specifically on the use of stem cells in skeletal tissue generation for a broad audience of stem cell, cancer, and bone biologists, orthopedists, oncologists, and regenerative medicine specialistsProvides a short historical 'detour' and foundational information on founding concepts, discoveries and personalities in MSC researchAssists a new generation of scientists and clinicians in digesting the multitude of journal articles on the topic by providing easily-absorbed and condensed foundational context.

Mesenchymal Stem Cells and Skeletal Regeneration

Mesenchymal Stem Cells and Skeletal Regeneration
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 2013
ISBN 10: 1928374650XXX
ISBN 13: LCCN:2013427134
Language: EN, FR, DE, ES & NL

Mesenchymal Stem Cells and Skeletal Regeneration Book Review:

This book covers our current understanding of the role of mesenchymal stem cells (MSCs) and other mesenchymal progenitors in skeletal regeneration, encompassing bone, cartilage and whole joint regeneration. The expansion reflects developments in the field to include data on the use of MSCs in drug development, growth factors, scaffolds and biomechanical manipulations for skeletal trauma and diseases, including osteoporosis and arthritis. Written for an audience of clinicians and young researchers who are exposed to MSCs in their work, this work summarizes recent findings pertaining to the definition and characterization of MSCs in skeletal tissues and discusses the mechanisms of their actions in regeneration of bone in vivo. The authors describe recent findings pertaining to the efficacy of MSC therapies in animal models and in human clinical trials and bring together literature showing that the ways MSCs are extracted, expanded and implanted can considerably affect bone formation outcomes. Finally, it presents the latest knowledge on the nature of native MSCs in skeletal tissues, which provide a platform for novel in situ tissue regeneration approaches for systemic bone disease such as osteoporosis. Focuses specifically on the use of stem cells in skeletal tissue generation for a broad audience of stem cell, cancer, and bone biologists, orthopedists, oncologists, and regenerative medicine specialistsProvides a short historical 'detour' and foundational information on founding concepts, discoveries and personalities in MSC researchAssists a new generation of scientists and clinicians in digesting the multitude of journal articles on the topic by providing easily-absorbed and condensed foundational context.

Mesenchymal Stem Cells in Human Health and Diseases

Mesenchymal Stem Cells in Human Health and Diseases
Author: Ahmed H.K. El-Hashash
Publsiher: Academic Press
Total Pages: 228
Release: 2020-01-07
ISBN 10: 0128205334
ISBN 13: 9780128205334
Language: EN, FR, DE, ES & NL

Mesenchymal Stem Cells in Human Health and Diseases Book Review:

Mesenchymal Stem Cells in Human Health and Diseases provides a contemporary overview of the fast-moving field of MSC biology, regenerative medicine and therapeutics. MSCs offer the potential to dramatically reduce human suffering from disease. Numerous MSC-based studies are ongoing each year, each offering hope for novel treatments in human disease. This book provides information on MSC application in well-studied human diseases and tissue repair/regeneration and recent advances in their research and treatment. These discoveries are placed within the structural context of tissue and developmental biology in sections dealing with recent advances in our understanding of MSC biology. Includes insights ranging from MSC biology and development through the derivation and identification and properties of MSCs Helps to identify potential innovative solutions for restoring normal morphogenesis and/or regeneration of diseased organs Discusses the fact-based promise of MSC therapeutics and regenerative medicine in the real world

Vascularization

Vascularization
Author: Eric M. Brey
Publsiher: CRC Press
Total Pages: 397
Release: 2014-08-07
ISBN 10: 1466580453
ISBN 13: 9781466580459
Language: EN, FR, DE, ES & NL

Vascularization Book Review:

A Complex and Growing Field The study of vascularization in tissue engineering and regenerative medicine (TERM) and its applications is an emerging field that could revolutionize medical approaches for organ and tissue replacement, reconstruction, and regeneration. Designed specifically for researchers in TERM fields, Vascularization: Regenerative Medicine and Tissue Engineering provides a broad overview of vascularization in TERM applications. This text summarizes research in several areas, and includes contributions from leading experts in the field. It defines the difficulties associated with multicellular processes in vascularization and cell-source issues. It presents advanced biomaterial design strategies for control of vascular network formation and in silico models designed to provide insight not possible in experimental systems. It also examines imaging methods that are critical to understanding vascularization in engineered tissues, and addresses vascularization issues within the context of specific tissue applications. This text is divided into three parts; the first section focuses on the basics of vascularization. The second section provides general approaches for promoting vascularization. The final section presents tissue and organ-specific aspects of vascularization in regenerative medicine. Presents Areas of Substantial Clinical and Societal Impact The material contains research and science on the process of vessel assembly with an emphasis on methods for controlling the process for therapeutic applications. It describes the tissue and organ-specific aspects of vascularization in regenerative medicine, and refers to areas such as bone tissue engineering, vascularization of encapsulated cells, adipose tissue, bone and muscle engineering. It also provides a mechanistic understanding of the process and presentation of experimental and computational approaches that facilitate the study of vascular assembly, and includes enabling technologies such as nanotechnology, drug delivery, stem cells, microfluidics, and biomaterial design that are optimized for supporting the formation of extensive vascular networks in regenerative medicine. A guide for researchers developing new methods for modulating vessel assembly, this text can also be used by senior undergraduate and graduate students taking courses focused on TERM.

Mesenchymal Stem Cells in Skeletal Muscle Regeneration

Mesenchymal Stem Cells in Skeletal Muscle Regeneration
Author: Anabel Sofía Garza-Rodea
Publsiher: Unknown
Total Pages: 245
Release: 2011
ISBN 10: 9789088913235
ISBN 13: 9088913234
Language: EN, FR, DE, ES & NL

Mesenchymal Stem Cells in Skeletal Muscle Regeneration Book Review:

The Growth Plate

The Growth Plate
Author: Irving M. Shapiro,Barbara Boyan,H. Clarke Anderson
Publsiher: IOS Press
Total Pages: 265
Release: 2002
ISBN 10: 9781586032401
ISBN 13: 1586032402
Language: EN, FR, DE, ES & NL

The Growth Plate Book Review:

Evidence generated by a number of genetic studies indicates that growth is regulated by a number of genes and that interference with their expression can have catastrophic effects on the well being of the whole organism. This work covers skeletal development and growth.

Bone and Cartilage Regeneration

Bone and Cartilage Regeneration
Author: Phuc Van Pham
Publsiher: Springer
Total Pages: 315
Release: 2017-01-24
ISBN 10: 3319401440
ISBN 13: 9783319401447
Language: EN, FR, DE, ES & NL

Bone and Cartilage Regeneration Book Review:

This invaluable resource discusses clinical applications with effects and side-effects of applications of stem cells in bone and cartilage regeneration. Each chapter is contributed by a pre-eminent scientist in the field and covers such topics as skeletal regeneration by mesenchymal stem cells, clinical improvement of mesenchymal stem cell injection in injured cartilage and osteoarthritis, Good manufacturing practice (GMP), minimal critera of stem cells for clinical applications, future directions of the discussed therapies and much more. Bone & Cartilage Regeneration and the other books in the Stem Cells in Clinical Applications series will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering.

Skeletal Muscle Repair and Regeneration

Skeletal Muscle Repair and Regeneration
Author: Stefano Schiaffino,Terence Partridge
Publsiher: Springer Science & Business Media
Total Pages: 379
Release: 2008-01-18
ISBN 10: 1402067682
ISBN 13: 9781402067686
Language: EN, FR, DE, ES & NL

Skeletal Muscle Repair and Regeneration Book Review:

Since the middle of the last century we have progressively built up a comprehensive descriptive model of the allied mechanisms that maintain our muscles at a size and strength appropriate to the functional demands upon them and that rapidly repair damaged muscles. This volume is an assemblage of the collective experience from the pick of major research groups investigating these aspects of muscle cell biology. It provides up-to-date coverage and presents a broad range of topics.

Advanced Techniques in Bone Regeneration

Advanced Techniques in Bone Regeneration
Author: Alessandro Rozim Zorzi,João Batista de Miranda
Publsiher: BoD – Books on Demand
Total Pages: 386
Release: 2016-08-31
ISBN 10: 9535125389
ISBN 13: 9789535125389
Language: EN, FR, DE, ES & NL

Advanced Techniques in Bone Regeneration Book Review:

Advanced Techniques in Bone Regeneration is a book that brings together over 15 chapters, written by leading practitioners and researchers, of the latest advances in the area, including surgical techniques, new discoveries, and promising methods involving biomaterials and tissue engineering. This book is intended for all who work in the treatment of disorders involving problems with the regeneration of bone tissue, are doctors or dentists, as well as are researchers and teachers involved in this exciting field of scientific knowledge.

Mesenchymal Stem Cell Therapy

Mesenchymal Stem Cell Therapy
Author: Lucas G. Chase,Mohan C Vemuri
Publsiher: Springer Science & Business Media
Total Pages: 456
Release: 2012-12-12
ISBN 10: 1627032002
ISBN 13: 9781627032001
Language: EN, FR, DE, ES & NL

Mesenchymal Stem Cell Therapy Book Review:

Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.

Stem Cells and Bone Tissue

Stem Cells and Bone Tissue
Author: Rajkumar Rajendram,Victor R. Preedy,Vinood Patel
Publsiher: CRC Press
Total Pages: 422
Release: 2013-01-23
ISBN 10: 1466578424
ISBN 13: 9781466578425
Language: EN, FR, DE, ES & NL

Stem Cells and Bone Tissue Book Review:

Stem cells potentially offer a novel therapeutic platform to treat bone disease. They also help the scientist understand the molecular and cellular aetiology of bone disorders. Gaining knowledge on the nature and application of stem cell sciences is a prerequisite for understanding their potential in treating or preventing bone disorders. Stem Cells and Bone Tissue is designed to address these areas in three sections: Introductory Text and Sources of Stem Cells for Skeletal Tissue Cellular and Molecular Aspects Conditions, Applications, Treatments and Repairs Coverage includes general aspects of stems cells, sources of stems cells, isolation and purification, applications in regeneration, nanoscale topography, myostatin (GDF-8) signalling, c-Jun, Lnk, cell-derived Factor 1/CXCR4, chromatin remodelling, osteoporosis, osteoarthritis, hypophosphatasia, osteopetrosis, osteogenesis, and many other areas of merit too numerous to mention.

Stem Cells and Bone Tissue

Stem Cells and Bone Tissue
Author: Rajkumar Rajendram,Victor R. Preedy,Vinood Patel
Publsiher: CRC Press
Total Pages: 422
Release: 2013-01-23
ISBN 10: 1466578416
ISBN 13: 9781466578418
Language: EN, FR, DE, ES & NL

Stem Cells and Bone Tissue Book Review:

Stem cells potentially offer a novel therapeutic platform to treat bone disease. They also help the scientist understand the molecular and cellular aetiology of bone disorders. Gaining knowledge on the nature and application of stem cell sciences is a prerequisite for understanding their potential in treating or preventing bone disorders. Stem Cells and Bone Tissue is designed to address these areas in three sections: Introductory Text and Sources of Stem Cells for Skeletal Tissue Cellular and Molecular Aspects Conditions, Applications, Treatments and Repairs Coverage includes general aspects of stems cells, sources of stems cells, isolation and purification, applications in regeneration, nanoscale topography, myostatin (GDF-8) signalling, c-Jun, Lnk, cell-derived Factor 1/CXCR4, chromatin remodelling, osteoporosis, osteoarthritis, hypophosphatasia, osteopetrosis, osteogenesis, and many other areas of merit too numerous to mention.

Mesenchymal Stem Cells

Mesenchymal Stem Cells
Author: Phuc Van Pham
Publsiher: BoD – Books on Demand
Total Pages: 300
Release: 2017-11-29
ISBN 10: 9535136151
ISBN 13: 9789535136156
Language: EN, FR, DE, ES & NL

Mesenchymal Stem Cells Book Review:

Mesenchymal Stem Cells: Isolation, Characterization, and Applications thoroughly presents the isolation, characterization, and some applications of mesenchymal stem cells in the clinic. The book has two parts: "Isolation and Characterization" and "Clinical Perspectives and Applications." In Part I, the subsequent chapters introduce some techniques in isolation, characterization, and purification of mesenchymal stem cells in different tissues. In Part II, some applications of mesenchymal stem cells in the popular diseases, which include cartilage regeneration, spinal cord injury, and osteoarthritis, are discussed. This book provides a succinct yet comprehensive overview of mesenchymal stem cells for advanced students, graduate students, and researchers.

Skeletal Regeneration by Mesenchymal Stem Cells What Else

Skeletal Regeneration by Mesenchymal Stem Cells  What Else
Author: José A. Andrades,Enrique Guerado,José Becerra,José Ma López-Puertas,Manuel Monleón,María C. Araque,Pedro Jiménez-Palomo,Plácido Zamora-Navas,Silvia Claros
Publsiher: Unknown
Total Pages: 135
Release: 2011
ISBN 10: 9789533076638
ISBN 13: 9533076631
Language: EN, FR, DE, ES & NL

Skeletal Regeneration by Mesenchymal Stem Cells What Else Book Review:

Stem Cell and Tissue Engineering

Stem Cell and Tissue Engineering
Author: Song Li,Nicolas L'Heureux,Jennifer H. Elisseeff
Publsiher: World Scientific
Total Pages: 448
Release: 2011
ISBN 10: 9814317055
ISBN 13: 9789814317054
Language: EN, FR, DE, ES & NL

Stem Cell and Tissue Engineering Book Review:

Tissue engineering integrates knowledge and tools from biological sciences and engineering for tissue regeneration. A challenge for tissue engineering is to identify appropriate cell sources. The recent advancement of stem cell biology provides enormous opportunities to engineer stem cells for tissue engineering. The impact of stem cell technology on tissue engineering will be revolutionary. This book covers state-of-the-art knowledge on the potential of stem cells for the regeneration of a wide range of tissues and organs and the technologies for studying and engineering stem cells. It serves as a valuable reference book for researchers and students.

Mesenchymal stem cells in Transplantation and Tissue Regeneration

Mesenchymal stem cells in Transplantation and Tissue Regeneration
Author: Martin J. Hoogduijn,Frank J. Dor
Publsiher: Frontiers E-books
Total Pages: 135
Release: 2013-08-23
ISBN 10: 2889191591
ISBN 13: 9782889191598
Language: EN, FR, DE, ES & NL

Mesenchymal stem cells in Transplantation and Tissue Regeneration Book Review:

Normal 0 false false false EN-GB X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0in; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-ansi-language:EN-GB;} Mesenchymal stem cells (MSC) have induced expansive interest from both scientific and clinical points of view over the last decennium. This interest stems from the capacity of these cells to differentiate into multiple lineages and from their secretion of growth factors that can activate progenitor cells, which make MSC potentially applicable for tissue regenerative purposes. When exposed to inflammatory conditions, MSC furthermore exhibit immunosuppressive properties. The reduction of chronic or acute inflammatory responses by MSC may halt the development of injury and allow regenerative processes to take place. This prospective has initiated attempts to use MSC as an immunosuppressive and regenerative agent in transplantation and regeneration of tissues like kidney, liver, heart, bone and multiple others. Nevertheless, the conditions under which MSC therapy is effective and via what mechanisms MSC operate are, in particular in in vivo settings, not clear. The route of administration and the reigning immunological conditions are likely to be key for the efficacy of MSC. Studies have demonstrated for instance that MSC may be immunostimulatory under immunological quiescent conditions. Whereas some reports indicate that homing of MSC to inflamed tissues and their secretion of growth and anti-inflammatory factors are responsible for their effect, others show that MSC rapidly disappear after administration and may not have time to actively contribute to immunosuppression and tissue repair. Many aspects of MSC have to be clarified in order to develop efficient therapies. In this special topic, different views on the mechanisms of immunomodulation and regeneration by MSC and on the possible applications of MSC in transplantation and tissue regeneration will be put together.

Skeletal Regeneration by Mesenchymal Stem Cells What Else

Skeletal Regeneration by Mesenchymal Stem Cells  What Else
Author: José A. Andrades
Publsiher: Unknown
Total Pages: 135
Release: 2011
ISBN 10: 1928374650XXX
ISBN 13: OCLC:1154214399
Language: EN, FR, DE, ES & NL

Skeletal Regeneration by Mesenchymal Stem Cells What Else Book Review:

Skeletal Regeneration by Mesenchymal Stem Cells: What Else?

Stem Cells

Stem Cells
Author: Mariusz Z. Ratajczak
Publsiher: Springer Nature
Total Pages: 406
Release: 2020-01-02
ISBN 10: 3030312062
ISBN 13: 9783030312060
Language: EN, FR, DE, ES & NL

Stem Cells Book Review:

Since different types of stem cells for therapeutic applications have recently been proposed, this timely volume explores various sources of stem cells for tissue and organ regeneration and discusses their advantages and limitations. Also discussed are pros and cons for using embryonic stem cells, induced pluripotent stem cells, and adult stem cells isolated from postnatal tissues. Different types of adult stem cells for therapeutic applications are also reviewed, including hematopoietic stem cells, epidermal stem cells, endothelial progenitors, neural stem cells, mesenchymal stem cells, and very small embryonic-like stem cells. This book also addresses paracrine effects of stem cells in regenerative medicine that are mediated by extracellular microvesicles and soluble secretome. Finally, potential applications of stem cells in cardiology, gastroenterology, neurology, immunotherapy, and aging are presented. This is an ideal book for students and researchers working in the stem cell research field.

Acute Muscle Injuries

Acute Muscle Injuries
Author: Gino M.M.J. Kerkhoffs,Elvire Servien
Publsiher: Springer Science & Business Media
Total Pages: 138
Release: 2014-02-18
ISBN 10: 3319037226
ISBN 13: 9783319037226
Language: EN, FR, DE, ES & NL

Acute Muscle Injuries Book Review:

This book documents current knowledge and standards of care for acute muscle injuries. The full range of injuries is covered, including those to the hamstring, hip adductor, quadriceps, calf, pectoralis major, biceps brachii, latissimus dorsi and rectus abdominis muscles. Evidence-based content is combined with experience from medical experts from around the globe in order to provide the reader with a full picture of the latest insights into terminology, trauma mechanisms, basic principles of healing, diagnosis and treatment. Helpful diagnostic and treatment algorithms are included and clear guidance provided on ensuring optimal rehabilitation and rapid return to sports. The book is structured in such a way that it will serve as an ideal reference manual for orthopaedic surgeons, sports medicine physicians, physiotherapists, general practitioners, paramedics, sports managers, athletes and coaches.