Mechanotransduction

Mechanotransduction
Author: Paul A. Sundaram
Publsiher: Academic Press
Total Pages: 158
Release: 2020-11-18
ISBN 10: 0128178833
ISBN 13: 9780128178836
Language: EN, FR, DE, ES & NL

Mechanotransduction Book Review:

Mechanotransduction: Cell Signaling to Cell Response covers the cell machinery responsible for the process of mechanotransduction and the manner in which cells respond to an external mechanical stimulus. The effect of mechanical stimulus on individual cells and entire tissues is discussed, with an emphasis on the practical results of this physiological process. Mechanotransduction of stem cells and cancerous cells are also covered, along with future directions in this yet nascent field. This book gives insights on basic processes that occur (or may occur) in the human body as a result of the application of mechanical stimulus. It is ideal for both biomedical engineers and biologists, and is an ideal resource for teaching. It provides a current state of conceptual and practical aspects of the field and will enable students and professionals to venture further into this incipient area which is of fundamental importance to biomedical engineering and biology fields. Covers fundamental concepts of signaling in cells as a result of mechanical stimulus Includes the physiological results of mechanical stimulus on the human body Explores the advantages of mechanical loads on the human body

Cellular Mechanotransduction

Cellular Mechanotransduction
Author: Mohammad R. K. Mofrad,Roger D. Kamm
Publsiher: Cambridge University Press
Total Pages: 135
Release: 2009-11-23
ISBN 10: 1316139476
ISBN 13: 9781316139479
Language: EN, FR, DE, ES & NL

Cellular Mechanotransduction Book Review:

'Mechanotransduction' is the term for the ability, first described by 19th-century anatomist Julius Wolff, of living tissues to sense mechanical stress and respond by tissue remodeling. More recently, the scope of mechanotransduction has been expanded to include the sensation of stress, its translation into a biochemical signal, and the sequence of biological responses it produces. This book looks at mechanotransduction in a more restricted sense, focusing on the process of stress sensing and transducing a mechanical force into a cascade of biochemical signals. This stress has become increasingly recognized as one of the primary and essential factors controlling biological functions, ultimately affecting the function of the cells, tissues, and organs. A primary goal of this broad book is also to help define the new field of mechanomics, which attempts to describe the complete mechanical state of a biological system.

Cellular Mechanotransduction Mechanisms in Cardiovascular and Fibrotic Diseases

Cellular Mechanotransduction Mechanisms in Cardiovascular and Fibrotic Diseases
Author: Anonim
Publsiher: Academic Press
Total Pages: 330
Release: 2021-10-22
ISBN 10: 0128215240
ISBN 13: 9780128215241
Language: EN, FR, DE, ES & NL

Cellular Mechanotransduction Mechanisms in Cardiovascular and Fibrotic Diseases Book Review:

Endothelial Signaling, Mechanotransduction, Vascular Biology and Atherosclerosis, Volume 87, the latest release in the Current Topics in Membranes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in "Current Topics in Membranes" series Updated release includes the latest information on Endothelial Signaling, Mechanotransduction, Vascular Biology and Atherosclerosis

T Cell Development

T Cell Development
Author: Remy Bosselut,Melanie S. Vacchio
Publsiher: Humana Press
Total Pages: 312
Release: 2016-10-28
ISBN 10: 9781493948437
ISBN 13: 1493948431
Language: EN, FR, DE, ES & NL

T Cell Development Book Review:

This volume provides simple and accessible experiment protocols to explore thymus biology. "T-Cell Development: Methods and Protocols" is divided into three parts presenting short reviews on T cell development, analysis strategies, protocols for cell preparation, flow cytometry analyses, and multiple aspects of thymocyte biology. As a volume in the highly successful Methods in Molecular Biology series, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Concise and easy-to-use, "T-Cell Development: Methods and Protocols" aims to ensure successful results in the further study of this vital field."

Mechanobiology in Health and Disease

Mechanobiology in Health and Disease
Author: Stefaan Verbruggen
Publsiher: Academic Press
Total Pages: 527
Release: 2018-08-09
ISBN 10: 0128129530
ISBN 13: 9780128129531
Language: EN, FR, DE, ES & NL

Mechanobiology in Health and Disease Book Review:

Mechanobiology in Health and Disease brings together contributions from leading biologists, clinicians, physicists and engineers in one convenient volume, providing a unified source of information for researchers in this highly multidisciplinary area. Opening chapters provide essential background information on cell mechanotransduction and essential mechanobiology methods and techniques. Other sections focus on the study of mechanobiology in healthy systems, including bone, tendons, muscles, blood vessels, the heart and the skin, as well as mechanobiology studies of pregnancy. Final chapters address the nascent area of mechanobiology in disease, from the study of bone conditions, skin diseases and heart diseases to cancer. A discussion of future perspectives for research completes each chapter in the volume. This is a timely resource for both early-career and established researchers working on mechanobiology. Provides an essential digest of primary research from many fields and disciplines in one convenient volume Covers both experimental approaches and descriptions of mechanobiology problems from mathematical and numerical perspectives Addresses the hot topic of mechanobiology in disease, a particularly dynamic field of frontier science

Mechanosensitivity and Mechanotransduction

Mechanosensitivity and Mechanotransduction
Author: Irina Kiseleva,Andre Kamkin
Publsiher: Springer Science & Business Media
Total Pages: 371
Release: 2010-11-18
ISBN 10: 904819881X
ISBN 13: 9789048198818
Language: EN, FR, DE, ES & NL

Mechanosensitivity and Mechanotransduction Book Review:

This book presents the latest findings in the field of research of mechanosensitivity and mechanotransduction in different cells and tissues. Mechanosensitivity and mechanotransduction of the heart and vascular cells, in the lung, in bone and joint tissues, in sensor systems and in blood cells are described in detail. This Volume focuses on molecular mechanisms of mechanosensitivity and mechanotransduction via cytoskeleton. Integrin-mediated mechanotransduction, the role of actin cytoskeleton and the role of other cytoskeletal elements are discussed. It contains a detailed description of several stretch-induced signaling cascades with multiple levels of crosstalk between different pathways. It contains a description of the role of nitric oxide in regulation of cardiac activity and in regulation of mechanically gated channels in the heart. In the heart mechanical signals are propagated into the intracellular space primarily via integrin-linked complexes, and are subsequently transmitted from cell to cell via paracrine signaling. Biochemical signals derived from mechanical stimuli activate both acute phosphorylation of signaling cascades, such as in the PI3K, FAK, and ILK pathways, and long-term morphological modii cations via intracellular cytoskeletal reorganization and extracellular matrix remodelling. Cellular and molecular effects of mechanical stretch on vascular cells are also discussed. This Volume highlights the role of mechanotransduction in the lung, in bone and joint tissues. For the first time mechanosensitivity and mechanotransduction in blood cells are discussed. It contains new insights into mechanosensitive K+ channels functioning in mouse B lymphocytes. This book is a unique collection of reviews outlining current knowledge and future developments in this rapidly growing field. Currently, investigations of the molecular mechanisms of mechanosensitivity and mechanotransduction are focused on several issues. The majority of studies investigate intracellular signaling pathways. Knowledge of the mechanisms which underlie these processes is necessary for understanding of the normal functioning of different organs and tissues and allows to predict changes, which arise due to alterations of their environment. Possibly such knowledge will allow the development of new methods of artificial intervention and therapies. This book brings up the problem closer to the experts in related medical and biological sciences as well as practicing doctors besides just presenting the latest achievements in the field.

Mechanobiology

Mechanobiology
Author: Simon Rawlinson
Publsiher: John Wiley & Sons
Total Pages: 432
Release: 2017-02-06
ISBN 10: 1118966147
ISBN 13: 9781118966143
Language: EN, FR, DE, ES & NL

Mechanobiology Book Review:

An emerging field at the interface of biology and engineering, mechanobiology explores the mechanisms by which cells sense and respond to mechanical signals—and holds great promise in one day unravelling the mysteries of cellular and extracellular matrix mechanics to cure a broad range of diseases. Mechanobiology: Exploitation for Medical Benefit presents a comprehensive overview of principles of mechanobiology, highlighting the extent to which biological tissues are exposed to the mechanical environment, demonstrating the importance of the mechanical environment in living systems, and critically reviewing the latest experimental procedures in this emerging field. Featuring contributions from several top experts in the field, chapters begin with an introduction to fundamental mechanobiological principles; and then proceed to explore the relationship of this extensive force in nature to tissues of musculoskeletal systems, heart and lung vasculature, the kidney glomerulus, and cutaneous tissues. Examples of some current experimental models are presented conveying relevant aspects of mechanobiology, highlighting emerging trends and promising avenues of research in the development of innovative therapies. Timely and important, Mechanobiology: Exploitation for Medical Benefit offers illuminating insights into an emerging field that has the potential to revolutionise our comprehension of appropriate cell biology and the future of biomedical research.

Mechanotransduction

Mechanotransduction
Author: Anonim
Publsiher: Academic Press
Total Pages: 384
Release: 2014-07-29
ISBN 10: 0123983274
ISBN 13: 9780123983275
Language: EN, FR, DE, ES & NL

Mechanotransduction Book Review:

Progress in Molecular Biology and Translational Science provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references. Volume 126 features in-depth reviews that focus on the tools required to investigate mechanotransduction. Additional chapters focus on how we can use these tools to answer fundamental questions about the interaction of physical forces with cell biology, morphogenesis, and function of mature structures. Chapters in the volume are authored by a unique combination of cell biologists and engineers, providing a range of perspectives on mechanotransduction. Provides a unique combination of perspectives from biologists and engineers Engaging to people of many training backgrounds

Current Topics in Membranes

Current Topics in Membranes
Author: Anonim
Publsiher: Academic Press
Total Pages: 453
Release: 1992-01-08
ISBN 10: 9780080585109
ISBN 13: 0080585108
Language: EN, FR, DE, ES & NL

Current Topics in Membranes Book Review:

Current Topics in Membranes

Molecular and Cellular Mechanobiology

Molecular and Cellular Mechanobiology
Author: Shu Chien,Adam J. Engler,Peter Yingxiao Wang
Publsiher: Springer
Total Pages: 302
Release: 2016-08-10
ISBN 10: 1493956175
ISBN 13: 9781493956173
Language: EN, FR, DE, ES & NL

Molecular and Cellular Mechanobiology Book Review:

This book will cover the cutting-edge developments in molecular and cellular mechanobiology to date. Readers will have a clear understanding of mechanobiology at the molecular and cellular levels, encompassing the mechanosensors, transducers, and transcription. An integrative approach across different scales from molecular sensing to mechanotransduction and gene modulation for physiological regulation of cellular functions will be explored, as well as applications to pathophysiological states in disease. A comprehensive understanding of the roles of physicochemical microenvironment and intracellular responses in determining cellular function in health and disease will also be discussed.

Mechanosensitive Ion Channels

Mechanosensitive Ion Channels
Author: Anonim
Publsiher: Elsevier
Total Pages: 616
Release: 2011-09-21
ISBN 10: 0080494404
ISBN 13: 9780080494401
Language: EN, FR, DE, ES & NL

Mechanosensitive Ion Channels Book Review:

Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology. This series has been a mainstay for practicing scientists and students interested in this critical field of biology. Articles covered in the volume include ENaC Proteins in Vascular Smooth Muscle Mechanotransduction; Regulation of the Mechano-Gated K2P Channel TREK-1 by Membrane Phospholipids; MechanoTRPs and TRPA1; TRPC; The Cytoskeletal Connection to Ion Channels as a Potential Mechanosensory Mechanism. Lessons From Polycystin-2 (TRPP2); Lipid Stress at Play: Mechanosensitivity of Voltage-Gated Channels; Hair Cell Mechanotransduction: The Dynamic Interplay between Structure and Function; Pharmacology of Hair Cell MS Channels; Hair Cell Mechanotransduction; Models of Hair Cell Mechanotrasduction; Touch; Mechanosensitive Ion Channels in Dystrophic Muscle; Mechanotransduction in Endothelial Cells; MS Channels in Tumor Cell Migration; Mechanosensitive Channels in Regulating Smooth Muscle Contraction in the GI; Mechanosensitive Ion Channels in Blood-Pressure-Sensing Baroreceptor Neurons.

Cardiac Mechanotransduction

Cardiac Mechanotransduction
Author: Matti Weckström,Pasi Tavi
Publsiher: Springer Science & Business Media
Total Pages: 159
Release: 2007-12-22
ISBN 10: 0387488685
ISBN 13: 9780387488684
Language: EN, FR, DE, ES & NL

Cardiac Mechanotransduction Book Review:

This book presents a multidisciplinary approach to cardiac mechanotransduction. The chapters depict the many faces of the topic, from membrane and ion channel level to mechanics, biochemical signaling and regulation via hormone systems. Cardiac Mechanotransduction is of interest to basic life sciences, like physiology, biochemistry and pharmacology, but also to clinicians working with heart-related problems, such as cardiologists and internists.

Mechanosensitivity and Mechanotransduction

Mechanosensitivity and Mechanotransduction
Author: Irina Kiseleva,Andre Kamkin
Publsiher: Springer Science & Business Media
Total Pages: 371
Release: 2010-11-18
ISBN 10: 904819881X
ISBN 13: 9789048198818
Language: EN, FR, DE, ES & NL

Mechanosensitivity and Mechanotransduction Book Review:

This book presents the latest findings in the field of research of mechanosensitivity and mechanotransduction in different cells and tissues. Mechanosensitivity and mechanotransduction of the heart and vascular cells, in the lung, in bone and joint tissues, in sensor systems and in blood cells are described in detail. This Volume focuses on molecular mechanisms of mechanosensitivity and mechanotransduction via cytoskeleton. Integrin-mediated mechanotransduction, the role of actin cytoskeleton and the role of other cytoskeletal elements are discussed. It contains a detailed description of several stretch-induced signaling cascades with multiple levels of crosstalk between different pathways. It contains a description of the role of nitric oxide in regulation of cardiac activity and in regulation of mechanically gated channels in the heart. In the heart mechanical signals are propagated into the intracellular space primarily via integrin-linked complexes, and are subsequently transmitted from cell to cell via paracrine signaling. Biochemical signals derived from mechanical stimuli activate both acute phosphorylation of signaling cascades, such as in the PI3K, FAK, and ILK pathways, and long-term morphological modii cations via intracellular cytoskeletal reorganization and extracellular matrix remodelling. Cellular and molecular effects of mechanical stretch on vascular cells are also discussed. This Volume highlights the role of mechanotransduction in the lung, in bone and joint tissues. For the first time mechanosensitivity and mechanotransduction in blood cells are discussed. It contains new insights into mechanosensitive K+ channels functioning in mouse B lymphocytes. This book is a unique collection of reviews outlining current knowledge and future developments in this rapidly growing field. Currently, investigations of the molecular mechanisms of mechanosensitivity and mechanotransduction are focused on several issues. The majority of studies investigate intracellular signaling pathways. Knowledge of the mechanisms which underlie these processes is necessary for understanding of the normal functioning of different organs and tissues and allows to predict changes, which arise due to alterations of their environment. Possibly such knowledge will allow the development of new methods of artificial intervention and therapies. This book brings up the problem closer to the experts in related medical and biological sciences as well as practicing doctors besides just presenting the latest achievements in the field.

Collagen

Collagen
Author: Peter Fratzl
Publsiher: Springer Science & Business Media
Total Pages: 506
Release: 2008-05-10
ISBN 10: 0387739068
ISBN 13: 9780387739069
Language: EN, FR, DE, ES & NL

Collagen Book Review:

Not only does this book provide a comprehensive review of current research advances in collagen structure and mechanics, it also explores this biological macromolecule’s many applications in biomaterials and tissue engineering. Readers gain an understanding of the structure and mechanical behavior of type I collagen and collagen-based tissues in vertebrates across all length scales, from the molecular (nano) to the organ (macro) level.

Mechanotransduction of the Hair Cell

Mechanotransduction of the Hair Cell
Author: Wei Xiong,Zhigang Xu
Publsiher: Springer
Total Pages: 60
Release: 2018-04-27
ISBN 10: 9811085579
ISBN 13: 9789811085574
Language: EN, FR, DE, ES & NL

Mechanotransduction of the Hair Cell Book Review:

This book summarizes the emerging experimental evidence on hair-cell mechanotransduction, and covers hair’s cellular structure, biophysical properties, molecular components and functions. Auditory hair cells convert sound-induced vibration into electrical signals. This biological process, mechanotransduction, is what allows us to hear and communicate in our daily lives. However, our grasp of hair-cell mechanotransduction is still far from complete. Recent advances in molecular genetics and biophysics have helped us gain deeper insights into this process, especially the molecular constituent and operation of the channel complex. This book provides a cutting-edge snapshot for all readers who are interested in or studying how auditory hair cells detect sound.

Cellular and Biomolecular Mechanics and Mechanobiology

Cellular and Biomolecular Mechanics and Mechanobiology
Author: Amit Gefen
Publsiher: Springer Science & Business Media
Total Pages: 562
Release: 2010-12-02
ISBN 10: 3642142184
ISBN 13: 9783642142185
Language: EN, FR, DE, ES & NL

Cellular and Biomolecular Mechanics and Mechanobiology Book Review:

This book describes these exciting new developments, and presents experimental and computational findings that altogether describe the frontier of knowledge in cellular and biomolecular mechanics, and the biological implications, in health and disease. The book is written for bioengineers with interest in cellular mechanics, for biophysicists, biochemists, medical researchers and all other professionals with interest in how cells produce and respond to mechanical loads.

Stretch Intensity and the Inflammatory Response A Paradigm Shift

Stretch Intensity and the Inflammatory Response  A Paradigm Shift
Author: Nikos C. Apostolopoulos
Publsiher: Springer
Total Pages: 231
Release: 2018-12-27
ISBN 10: 3319968009
ISBN 13: 9783319968001
Language: EN, FR, DE, ES & NL

Stretch Intensity and the Inflammatory Response A Paradigm Shift Book Review:

In this manuscript, practitioners and students who are concerned with sports and rehabilitation medicine, kinesiology, as well as coaches and athletes, are introduced to numerous concepts, including mechanotransduction, inflammation, pro- and anti-inflammatory cytokines, calpains, the extracellular matrix, neutrophils and macrophages, and their relevance to stretching, particularly stretching intensity. Although the quantitative parameters of training, duration, and frequency are important, it is the qualitative criterion of intensity (“how much”) that the author suggests is ultimately of greater concern. Intensity, the rate and magnitude of force, may be responsible for the proper recovery, regeneration, and adaptation of the musculoskeletal tissues from training, competition, or rehabilitation from injuries. Research suggests that too much force results in the stimulation of an inflammatory response, one associated with a biochemical feedback emerging from a mechanical stimulus. The intent of this manuscript is twofold: to initiate the discussion of the importance of stretching intensity with regard to proper recovery, regeneration, and adaptation, and to suggest that researchers need to explore its potential role in addressing numerous inflammatory (RA) and non-inflammatory (OA, recurrent tendinitis etc.) musculoskeletal conditions as well.

Mechanochemistry in Materials

Mechanochemistry in Materials
Author: Yoan C. Simon,Stephen L. Craig
Publsiher: Royal Society of Chemistry
Total Pages: 210
Release: 2017-10-24
ISBN 10: 1782621466
ISBN 13: 9781782621461
Language: EN, FR, DE, ES & NL

Mechanochemistry in Materials Book Review:

With tremendous growth over the last five years, mechanochemistry has become one of the most important topics in current polymer science research. With a particular focus on polymers and soft materials, Mechanochemistry in Materialslooks at the subject from the application of macroscopic forces to solid systems of macroscopic dimensions. The book has been divided according to length scale covering both experimental and theoretical considerations simultaneously. The first section of the book focuses on inspiration from nature, exploring and explaining multiple biological phenomena. The second section discusses molecular mechanochemistry, including the theoretical understanding of the transduction of mechanical force and its impact on covalent bonds cleavage and formation. The final section considers the implementation of these phenomena at the mesoscale and discusses the use of supramolecular/reversible aspects with similarities to biological systems. The book provides a unique comparison with natural systems and contains all the important achievements in the area from the last decade. Appealing to a broad range of materials scientists, working in industry and academia, this well-presented and comprehensive title will be essential reading for researchers. . The book provides a unique comparison with natural systems and contains all the important achievements in the area from the last decade. Appealing to a broad range of materials scientists, working in industry and academia, this well-presented and comprehensive title will be essential reading for researchers. . The book provides a unique comparison with natural systems and contains all the important achievements in the area from the last decade. Appealing to a broad range of materials scientists, working in industry and academia, this well-presented and comprehensive title will be essential reading for researchers. . The book provides a unique comparison with natural systems and contains all the important achievements in the area from the last decade. Appealing to a broad range of materials scientists, working in industry and academia, this well-presented and comprehensive title will be essential reading for researchers.

Scaffolds in Tissue EngineeringMaterials Technologies and Clinical Applications

Scaffolds in Tissue EngineeringMaterials  Technologies and Clinical Applications
Author: Francesco Baino
Publsiher: BoD – Books on Demand
Total Pages: 332
Release: 2017-12-13
ISBN 10: 9535136410
ISBN 13: 9789535136415
Language: EN, FR, DE, ES & NL

Scaffolds in Tissue EngineeringMaterials Technologies and Clinical Applications Book Review:

Biomaterials are often designed to act as scaffolds, i.e., 3D porous templates that support and stimulate the growth of healthy tissue and then safely dissolve once they have performed their functions. This book provides a picture of the current state of the art in the field of scaffolds for tissue engineering, highlighting the potential associated to the latest scientific and technological advancements. The former part of the book focuses on the repair of "hard" tissues (primarily bone) by means of bioceramic/glass scaffolds, and the latter deals with the applications of polymeric scaffolds for regenerating "soft" tissues and structures including the peripheral nerve, heart, gastric mucosa and pancreas. Special emphasis is given to the challenges associated to scaffold manufacturing, biomimetic properties and cell-scaffold interactions.

Modern Mechanobiology

Modern Mechanobiology
Author: Juhyun Lee,Sharon Gerecht,Hanjoong Jo,Tzung Hsiai
Publsiher: CRC Press
Total Pages: 262
Release: 2021-02-25
ISBN 10: 1000021262
ISBN 13: 9781000021264
Language: EN, FR, DE, ES & NL

Modern Mechanobiology Book Review:

Modern mechanobiology converges both engineering and medicine to address personalized medicine. This book is built on the previously well-received edition, Hemodynamics and Mechanobiology of Endothelium. The central theme is "omic" approaches to mechanosignal transduction underlying tissue development, injury, and repair. A cadre of investigators has contributed to the chapters, enriching the interface between mechanobiology and precision medicine for personalized diagnosis and intervention. The book begins with the fundamental basis of vascular disease in response to hemodynamic shear stress and then details cardiovascular development and regeneration, valvular and cardiac morphogenesis, mechanosensitive microRNA and histone unfolding, computational fluid dynamics, and light-sheet imaging. This edition represents a paradigm shift from traditional biomechanics and signal transduction to transgenic models, including novel zebrafish and chick embryos, and targets a wider readership from academia to industry and government agencies in the field of mechanobiology.