Mechanisms of Cell Death and Opportunities for Therapeutic Development

Mechanisms of Cell Death and Opportunities for Therapeutic Development
Author: Diaqing Liao
Publsiher: Elsevier
Total Pages: 660
Release: 2021-11-15
ISBN 10: 0128142081
ISBN 13: 9780128142080
Language: EN, FR, DE, ES & NL

Mechanisms of Cell Death and Opportunities for Therapeutic Development Book Review:

Mechanisms of Cell Death and Opportunities for Therapeutic Development, volume four in the Perspectives in Translational Cell Biology series, offers content for professors, students and researchers across basic and translational biology. The book covers fundamental mechanisms, ranging from different forms of cell death and drug development, to efforts for treating disease, providing a valuable resource for readers interested in understanding cell death and relevant translational research. The book's editor, Diaqing Liao, has over twenty years' experience teaching topics of cell death. Provides a comprehensive overview of current knowledge on the process of apoptosis, its potential role in health and disease, and a discussion of potential alternative forms, such as autophagy Covers fundamental mechanisms and relevant translational research

Mechanisms of Cell Death and Opportunities for Therapeutic Development

Mechanisms of Cell Death and Opportunities for Therapeutic Development
Author: Diaqing Liao
Publsiher: Academic Press
Total Pages: 296
Release: 2021-10-26
ISBN 10: 012814209X
ISBN 13: 9780128142097
Language: EN, FR, DE, ES & NL

Mechanisms of Cell Death and Opportunities for Therapeutic Development Book Review:

Mechanisms of Cell Death and Opportunities for Therapeutic Development, volume four in the Perspectives in Translational Cell Biology series, offers content for professors, students and researchers across basic and translational biology. The book covers fundamental mechanisms, ranging from different forms of cell death and drug development, to efforts for treating disease, providing a valuable resource for readers interested in understanding cell death and relevant translational research. The book's editor, Diaqing Liao, has over twenty years’ experience teaching topics of cell death. Provides a comprehensive overview of current knowledge on the process of apoptosis, its potential role in health and disease, and a discussion of potential alternative forms, such as autophagy Covers fundamental mechanisms and relevant translational research

Sixth Euroconference on Mechanisms of Cell Death and Disease

Sixth     Euroconference on Mechanisms of Cell Death and Disease
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 2006
ISBN 10: 1928374650XXX
ISBN 13: OCLC:708295103
Language: EN, FR, DE, ES & NL

Sixth Euroconference on Mechanisms of Cell Death and Disease Book Review:

Fifth Interdiciplinary Conference on Mechanisms of Cell Death and Disease

Fifth Interdiciplinary Conference on Mechanisms of Cell Death and Disease
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 2004
ISBN 10: 1928374650XXX
ISBN 13: OCLC:708288571
Language: EN, FR, DE, ES & NL

Fifth Interdiciplinary Conference on Mechanisms of Cell Death and Disease Book Review:

Cell Death

Cell Death
Author: Hao Wu
Publsiher: Springer Science & Business Media
Total Pages: 272
Release: 2013-11-19
ISBN 10: 1461493021
ISBN 13: 9781461493020
Language: EN, FR, DE, ES & NL

Cell Death Book Review:

Beginning from centuries of anecdotal descriptions of cell death, such as those on the development of the midwife toad in 1842 by Carl Vogt, to modern-day investigations of cell death as a biological discipline, it has become accepted that cell death in multicellular organisms is a normal part of life. This book provides a comprehensive view of cell death, from its mechanisms of initiation and execution, to its implication in human disease and therapy. Physiological cell death plays critical roles in almost all aspects of biology, and the book details its roles in lymphocyte homeostasis, neuronal function, metabolism, and the DNA damage response. When physiological cell death goes awry, diseases can arise, and cancer is presented as a central paradigm for the consequences of derangements in the interplay between cell survival and cell death. At the same time, the potential promise of targeted therapies aimed at interdicting cell death machineries are also discussed extensively. The molecular mechanisms that underlie apoptotic cell death are illustrated from the perspectives of both the intrinsic, mitochondrial apoptotic pathway and the extrinsic, death receptor pathway. Key players in these pathways, such as the Bcl2 family proteins, cytochrome c, Apaf-1, caspases, death receptor adapter proteins, and inhibitor of apoptosis proteins, are presented from both functional and structural angles. Until only a few years ago, programmed cell death has been considered essentially synonymous with apoptosis. However, we now know that programmed cell death can also take other forms such as necrosis or necroptosis, and to this end, the mechanisms that underlie programmed necrosis in development and host defense are illustrated. The past twenty plus years have seen an incredible growth of research in cell death, with one breakthrough after another, and the legacy still goes on with constant new surprises and findings. Long live cell death!

Death Receptors in Cancer Therapy

Death Receptors in Cancer Therapy
Author: Wafik S. El-Deiry
Publsiher: Springer Science & Business Media
Total Pages: 374
Release: 2007-11-15
ISBN 10: 159259851X
ISBN 13: 9781592598519
Language: EN, FR, DE, ES & NL

Death Receptors in Cancer Therapy Book Review:

An in depth review of our latest understanding of the molecular events that regulate cell death and those molecules that provide targets for developing agonists or antagonists to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particular interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands.

Cell Death Signaling in Cancer Biology and Treatment

Cell Death Signaling in Cancer Biology and Treatment
Author: Daniel Johnson
Publsiher: Springer Science & Business Media
Total Pages: 408
Release: 2012-11-19
ISBN 10: 1461458471
ISBN 13: 9781461458470
Language: EN, FR, DE, ES & NL

Cell Death Signaling in Cancer Biology and Treatment Book Review:

A key goal in the treatment of cancer is to achieve selective and efficient killing of tumor cells. The aim of Cell Death Signaling in Cancer Biology and Treatment is to describe state-of-the-art approaches and future opportunities for achieving this goal by targeting mechanisms and pathways that regulate cancer cell death. In this book, molecular defects in cell death signaling that characterize cancer cells, including dysregulation of cell death due to overexpression/hyperactivation of oncoproteins, as well as the loss of tumor suppressor proteins will be described. The potential for targeting microRNAs will be discussed. Multiple chapters will describe preclinical and clinical approaches that are currently being used to target epigenetic modifications, DNA repair pathways, and protein chaperones, as a means of provoking tumor cell death. Finally, the development and application of novel agents and approaches for targeting specific components of cell death signaling pathways and machinery will be reviewed.

Proteasome Inhibitors in Cancer Therapy

Proteasome Inhibitors in Cancer Therapy
Author: Julian Adams
Publsiher: Springer Science & Business Media
Total Pages: 313
Release: 2004-05-25
ISBN 10: 1592597947
ISBN 13: 9781592597949
Language: EN, FR, DE, ES & NL

Proteasome Inhibitors in Cancer Therapy Book Review:

A panel of leading academic and pharmaceutical investigators takes stock of the remarkable work that has been accomplished to date with proteasome inhibitors in cancer, and examines emerging therapeutic possibilities. The topics range from a discussion of the chemistry and cell biology of the proteasome and the rationale for proteasome inhibitors in cancer to a review of current clinical trials underway. The discussion of rationales for testing proteasome inhibitors in cancer models covers the role of the proteasome in NF-kB activation, the combining of conventional chemotherapy and radiation with proteasome inhibition, notably PS-341, new proteasome methods of inhibiting viral maturation, and the role of protesome inhibition in the treatment of AIDS. The authors also document the development of bortezomib (VelcadeTM) in Phase I clinical trials and in a multicentered Phase II clinical trials in patients with relapsed and refractory myeloma.

Regulated Cell Death Part A

Regulated Cell Death Part A
Author: Avi Ashkenazi,Junying Yuan,Jim Wells
Publsiher: Elsevier
Total Pages: 504
Release: 2014-06-25
ISBN 10: 0124171753
ISBN 13: 9780124171756
Language: EN, FR, DE, ES & NL

Regulated Cell Death Part A Book Review:

Regulated Cell Death Part A & Part B of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in apoptosis focusing on the important areas of intrinsic pathway, extrinsic pathway, caspases, cellular assays and post-apoptotic effects and model organisms; as well as topics on necroptosis and screening approaches. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in biomineralization science Regulated Cell Death Part A & Part B contains sections on such topics as apoptosis focusing on the important areas of intrinsic pathway, extrinsic pathway, caspases, cellular assays and post-apoptotic effects and model organisms; as well as topics on necroptosis and screening approaches

Lysosomes

Lysosomes
Author: Frederick R. Maxfield,James M. Willard,Shuyan Lu
Publsiher: John Wiley & Sons
Total Pages: 544
Release: 2016-05-31
ISBN 10: 1118978307
ISBN 13: 9781118978306
Language: EN, FR, DE, ES & NL

Lysosomes Book Review:

Discussing recent findings, up-to-date research, and novel strategies, the book integrates perspectives from pharmacology, toxicology, and biochemistry to illustrate the potential of lysosomes in drug discovery and development. • Explores basic principles and properties of lysosomes that allow them to act as regulators of cell metabolism, therapeutic targets, and sites for activation of drug conjugates • Discusses the role of lysosomes in metabolism, drug targeting, apoptosis, cancer, aging, inflammation, autophagy, metabolism, toxicity, and membrane repair • Introduces new pathways in therapeutic development and new mechanisms in drug development

Regulated Cell Death Part B

Regulated Cell Death Part B
Author: Avi Ashkenazi,James A. Wells,Junying Yuan
Publsiher: Academic Press
Total Pages: 352
Release: 2014
ISBN 10: 9780128014301
ISBN 13: 012801430X
Language: EN, FR, DE, ES & NL

Regulated Cell Death Part B Book Review:

Regulated Cell Death Part A & Part B of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in apoptosis focusing on the important areas of intrinsic pathway, extrinsic pathway, caspases, cellular assays and post-apoptotic effects and model organisms; as well as topics on necroptosis and screening approaches. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in biomineralization science Regulated Cell Death Part A & Part B contains sections on such topics as apoptosis focusing on the important areas of intrinsic pathway, extrinsic pathway, caspases, cellular assays and post-apoptotic effects and model organisms; as well as topics on necroptosis and screening approaches

Programmed Cell Death

Programmed Cell Death
Author: Roya Khosravi-Far,Zahra Zakeri,Richard A. Lockshin,Mauro Piacentini
Publsiher: Elsevier
Total Pages: 504
Release: 2008-07-29
ISBN 10: 9780080888132
ISBN 13: 0080888135
Language: EN, FR, DE, ES & NL

Programmed Cell Death Book Review:

One of the major goals of researchers in the field of apoptosis is to identify targets for novel therapies in cancer, AIDS, and Alzheimer’s disease. Understanding the molecular mechanisms of the various components of the apoptotic pathways is the first step to reaching this goal. The 2002 Nobel Prize in Physiology or Medicine was awarded to Sydney Brenner (United Kingdom), H. Robert Horvitz (US) and John E. Sulston (UK) "for their discoveries concerning genetic regulation of organ development and programmed cell death." Cell death is a fundamental aspect of embryonic development, normal cellular turnover and maintenance of homeostasis (maintaining a stable, constant environment) on the one hand, and aging and disease on the other. This volume addresses the significant advances with the techniques that are being used to analyze cell death. * This volume provides the necessary, trusted methods to carry out this research on these latest therapeutic techniques. Once researchers understand the molecular mechanisms of the apoptotic pathways, they can begin to develop new therapies. * Presents key methods on studying tumors and how these cancer cells evade cell death. * Eliminates searching through many different sources to avoid pitfalls so the same mistakes are not made over and over.

Programmed Cell Death The Biology and Therapeutic Implications of Cell Death

Programmed Cell Death  The Biology and Therapeutic Implications of Cell Death
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 2008
ISBN 10: 1928374650XXX
ISBN 13: OCLC:760727819
Language: EN, FR, DE, ES & NL

Programmed Cell Death The Biology and Therapeutic Implications of Cell Death Book Review:

Cell Survival and Cell Death

Cell Survival and Cell Death
Author: Eric H. Baehrecke,Sally Kornbloth,Douglas R. Green,Guy Salvesen
Publsiher: Much-in-Little
Total Pages: 380
Release: 2013
ISBN 10: 9781936113316
ISBN 13: 1936113317
Language: EN, FR, DE, ES & NL

Cell Survival and Cell Death Book Review:

Billions of cells die every day in the human body. This is required for normal development and physiology, as well as the elimination of errant cells. Apoptosis and other cell death mechanisms are complex and carefully controlled. If cell death does not occur when it should, cancer and other diseases may develop. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers all aspects of apoptosis, autophagy, and necrosis. Contributors describe in detail the molecular mechanisms of cell death signaling, including death receptor-ligand systems, BCL-2 family proteins, mitochondrial permeabilization, the endocytic pathway, caspases, and signals that trigger the clearance of dying cells. Survival mechanisms and proteins such as IAPs that antagonize cell death are also described. This volume includes discussion of tumor suppression, the altered metabolism of cancer cells, and the development of therapeutic drugs. It is an essential reference for cell and developmental biologists, cancer biologists, and all who want to understand when and how cell death is required for life.

Mechanisms of Cell Death and Approaches to Neuroprotection Disease Modification in Parkinson s Disease

Mechanisms of Cell Death and Approaches to Neuroprotection Disease Modification in Parkinson   s Disease
Author: Anonim
Publsiher: Academic Press
Total Pages: 314
Release: 2021-11-10
ISBN 10: 0323899447
ISBN 13: 9780323899444
Language: EN, FR, DE, ES & NL

Mechanisms of Cell Death and Approaches to Neuroprotection Disease Modification in Parkinson s Disease Book Review:

Mechanisms of Cell Death and Approaches to Neuroprotection/Disease Modification in Parkinson’s Disease explores the results of numerous studies surrounding in vitro and animal model evidence that looks at the impact of a-synucleinopathy on neuronal dysfunction and behavioral impairments, (ii) how research in animal models supports the development of therapeutic strategies, and (iii) how findings in animal models might relate to the disease process in humans. In this book, the author's shed light upon the complex scenario of the mechanisms of cell death and approaches to neuroprotection/disease modification in PD, both in vitro to in vivo. Along with degeneration, the pathological hallmark of PD is the presence of intraneuronal proteinaceous cytoplasmic inclusions, named Lewy Bodies (LB) that invade the whole nervous system as the disease progresses. Several fundamental discoveries have shed light upon the implication of the a-syn protein in the pathogenesis of familial and sporadic forms of PD. Other proteins also accumulate in LB, but a-syn is a major protein component of the pathological landmarks. Updates on the latest research surrounding Mechanisms of Cell Death in Parkinson’s Disease Includes In vitro and In vivo models of synucleinopathy Presents therapeutic strategies in Parkinson’s Disease

Sensitization of Cancer Cells for Chemo Immuno Radio therapy

Sensitization of Cancer Cells for Chemo Immuno Radio therapy
Author: Benjamin Bonavida
Publsiher: Springer Science & Business Media
Total Pages: 420
Release: 2008-07-31
ISBN 10: 9781597454742
ISBN 13: 1597454745
Language: EN, FR, DE, ES & NL

Sensitization of Cancer Cells for Chemo Immuno Radio therapy Book Review:

This book reviews novel approaches developed to reverse tumor cell resistance to chemo/immuno/radio-therapy and the use of various sensitizing agents in combination with various cytotoxics. It also introduces several current approaches developed by established investigators that are aimed at overcoming resistance. This is the first volume to compile studies on tumor cell sensitization. It will prove useful for students, scientists, clinicians and pharmaceutical companies.

Molecular mechanisms of cellular stress responses in cancer and their therapeutic implications

Molecular mechanisms of cellular stress responses in cancer and their therapeutic implications
Author: Megan Chircop,Daniel Speidel
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2015-03-06
ISBN 10: 2889194965
ISBN 13: 9782889194964
Language: EN, FR, DE, ES & NL

Molecular mechanisms of cellular stress responses in cancer and their therapeutic implications Book Review:

In response to stress, cells can activate a myriad of signalling pathways to bring about a specific cellular outcome, including cell cycle arrest, DNA repair, senescence and apoptosis. This response is pivotal for tumour suppression as all of these outcomes result in restriction of the growth and/or elimination of damaged and pre-malignant cells. Thus, a large number of anti-cancer agents target specific components of stress response signalling pathways with the aim of causing tumour regression by stimulating cell death. However, the efficacy of these agents is often impaired due to mutations in genes that are involved in these stress-responsive signalling pathways and instead the oncogenic potential of a cell is increased leading to the initiation and/or progression of tumourigenesis. Moreover, these genetic defects can increase or contribute to resistance to chemotherapeutic agents and/or radiotherapy. Modulating the outcome of cellular stress responses towards cell death in tumour cells without affecting surrounding normal cells is thus one of the ultimate aims in the development of new cancer therapeutics. To achieve this aim, a detailed understanding of cellular stress response pathways and their aberrations in cancer is required. This Research topic aims to reflect the broadness and complexity of this important area of cancer research.

Cell Death

Cell Death
Author: Douglas R. Green
Publsiher: Unknown
Total Pages: 250
Release: 2018-09-30
ISBN 10: 9781621822141
ISBN 13: 1621822141
Language: EN, FR, DE, ES & NL

Cell Death Book Review:

One million cells in our bodies die every second--they commit suicide by a mechanism known as apoptosis. Apoptosis is essential for survival of the body as a whole and has critical roles in various developmental processes and the immune system. In Cell Death, Douglas Green provides a clear and comprehensive view of apoptosis and other cell death mechanisms. Taking a bottom-up approach, he starts with the enzymes that perform the execution process (a family of proteases termed caspases) and examines their cellular targets and the ways in which they are activated. He then looks at the molecular machinery that links signals that cause cell death to caspases, emphasizing the importance of the BCL-2 family of proteins and the role of cytochrome c released from mitochondria. The final stage of the process, phagocytic removal of dead or dying cells, is also covered. Green outlines the roles of apoptosis and death mechanisms such as necrosis in embryogenesis, neuronal selection, and the development of self-tolerance in the immune system. In addition, he explains how cell death defends the body against cancer and traces the evolutionary origins of the apoptosis machinery back over a billion years. This new edition contains critical new information on recent exciting advances in the field, such as new forms for cell death and important insights into the mechanisms and control of apoptosis. The book is thus of great use to all biologists interested in how cells function in the context of multicellular organisms and will appeal to everyone from undergraduates encountering the topic for the first time to researchers actively working in the field.

Programmed Cell Death

Programmed Cell Death
Author: Hala Gali-Muhtasib,Omar Nasser Rahal
Publsiher: BoD – Books on Demand
Total Pages: 152
Release: 2020-01-15
ISBN 10: 1789847486
ISBN 13: 9781789847482
Language: EN, FR, DE, ES & NL

Programmed Cell Death Book Review:

This book incorporates developments in our understanding of cell death mechanisms and highlights recent advances in programmed cell death regulation processes. It provides the reader with the network of pathways targeted by herbal anticancer drugs and discusses the role of endoplasmic reticulum stress in cell death mechanisms in addition to highlighting the mechanisms of autophagy and its role in diseases. This book provides valuable material for researchers and for teaching postgraduate students. Emphasis on recent advances and their clinical applications offers insights to researchers that will likely lead to the development of novel therapeutic approaches.

Programmed Cell Death

Programmed Cell Death
Author: Roya Khosravi-Far,Zahra Zakeri,Richard A. Lockshin,Mauro Piacentini
Publsiher: Academic Press
Total Pages: 504
Release: 2008-08-12
ISBN 10: 9780123744647
ISBN 13: 0123744644
Language: EN, FR, DE, ES & NL

Programmed Cell Death Book Review:

One of the major goals of researchers in the field of apoptosis is to identify targets for novel therapies in cancer, AIDS, and Alzheimer's disease. Understanding the molecular mechanisms of the various components of the apoptotic pathways is the first step to reaching this goal. The 2002 Nobel Prize in Physiology or Medicine was awarded to Sydney Brenner (United Kingdom), H. Robert Horvitz (US) and John E. Sulston (UK) "for their discoveries concerning genetic regulation of organ development and programmed cell death." Cell death is a fundamental aspect of embryonic development, normal cellular turnover and maintenance of homeostasis (maintaining a stable, constant environment) on the one hand, and aging and disease on the other. This volume addresses the significant advances with the techniques that are being used to analyze cell death. * This volume provides the necessary, trusted methods to carry out this research on these latest therapeutic techniques. Once researchers understand the molecular mechanisms of the apoptotic pathways, they can begin to develop new therapies. * Presents key methods on studying tumors and how these cancer cells evade cell death. * Eliminates searching through many different sources to avoid pitfalls so the same mistakes are not made over and over.