Macrophages Biology and Role in the Pathology of Diseases

Macrophages  Biology and Role in the Pathology of Diseases
Author: Subhra K. Biswas,Alberto Mantovani
Publsiher: Springer
Total Pages: 615
Release: 2014-11-12
ISBN 10: 1493913115
ISBN 13: 9781493913114
Language: EN, FR, DE, ES & NL

Macrophages Biology and Role in the Pathology of Diseases Book Review:

Macrophages are a key component of the innate immune system and play an integral role in host defense and homeostasis. On one hand, these cells contribute to host defence by triggering inflammation, displaying microbicidal/tumoricidal properties, regulating the activation of adaptive immunity and promoting resolution of inflammation. On the other hand, they contribute to essential trophic functions such as neural patterning, bone morphogenesis and ductal branching in mammary glands. Thus, macrophages are extremely versatile cells that can respond efficiently to tissue micro environmental cues by polarizing to distinct phenotypes, depending on the functions they need to perform. Indeed, functional diversity and plasticity are hallmarks of these cells. Macrophages may also play a detrimental role. An overwhelming body of literature has indicated their crucial role in pathogenesis. The list includes sepsis, cancer, metabolic syndrome, immunodeficiency, auto-immune disease-virtually impacting every major pathology that we know. These observations have suggested macrophages and their related molecules as potential targets in therapeutic applications. Available evidence proclaims macrophages as a key player in homeostasis, host defense and disease. Crucial developments in the past few years call for a re-evaluation and update of our understanding of macrophages. The present book is an endeavour that attempts provide state-of-the art knowledge of these cells in health and disease.

M1 M2 Macrophages The Arginine Fork in the Road to Health and Disease

M1 M2 Macrophages  The Arginine Fork in the Road to Health and Disease
Author: Charles Dudley Mills,Laurel L Lenz,Klaus Ley
Publsiher: Frontiers Media SA
Total Pages: 280
Release: 2015-03-23
ISBN 10: 288919499X
ISBN 13: 9782889194995
Language: EN, FR, DE, ES & NL

M1 M2 Macrophages The Arginine Fork in the Road to Health and Disease Book Review:

Macrophages have unique and diverse functions necessary for survival. And, in humans (and other species), they are the most abundant leukocytes in tissues. The Innate functions of macrophages that are best known are their unusual ability to either “Kill” or “Repair”. Since killing is a destructive process and repair is a constructive process, it was stupefying how one cell could exhibit these 2 polar – opposite functions. However, in the late 1980’s, it was shown that macrophages have a unique ability to enzymatically metabolize Arginine to Nitric Oxide (NO, a gaseous non – specific killer molecule) or to Ornithine (a precursor of polyamines and collagen for repair). The dual Arginine metabolic capacity of macrophages provided a functional explanation for their ability to kill or repair. Macrophages predominantly producing NO are called M1 and those producing Ornithine are called M2. M1 and M2 – dominant responses occur in lower vertebrates, and in T cell deficient vertebrates being directly driven by Damage and Pathogen Associated Molecular Patterns (DAMP and PAMP). Thus, M1 and M2 are Innate responses that protect the host without Adaptive Immunity. In turn, M1/M2 is supplanting previous models in which T cells were necessary to “activate” or “alternatively activate” macrophages (the Th1/Th2 paradigm). M1 and M2 macrophages were named such because of the additional key findings that these macrophages stimulate Th1 and Th2 – like responses, respectively. So, in addition to their unique ability to kill or repair, macrophages also govern Adaptive Immunity. All of the foregoing would be less important if M1 or M2 – dominant responses were not observed in disease. But, they are. The best example to date is the predominance of M2 macrophages in human tumors where they act like wound repair macrophages and actively promote growth. More generally, humans have become M2 – dominant because sanitation, antibiotics and vaccines have lessened M1 responses. And, M2 dominance seems the cause of ever - increasing allergies in developed countries. Obesity represents a new and different circumstance. Surfeit energy (e.g., lipoproteins) causes monocytes to become M1 dominant in the vessel walls causing plaques. Because M1 or M2 dominant responses are clearly causative in many modern diseases, there is great potential in developing the means to selectively stimulate (or inhibit) either M1 or M2 responses to kill or repair, or to stimulate Th1 or Th2 responses, depending on the circumstance. The contributions here are meant to describe diseases of M1 or M2 dominance, and promising new methodologies to modulate the fungible metabolic machinery of macrophages for better health.

Janeway s Immunobiology

Janeway s Immunobiology
Author: Murphy, Kenneth M.,Weaver, Casey
Publsiher: W.W. Norton & Company
Total Pages: 904
Release: 2016-03-22
ISBN 10: 0815345518
ISBN 13: 9780815345510
Language: EN, FR, DE, ES & NL

Janeway s Immunobiology Book Review:

Explore the premier text for immunology at the advanced undergraduate, graduate, and medical school levels. Beginning students appreciate the bookÕs clear writing and informative illustrations, while advanced students and working immunologists value its comprehensive scope and depth. This edition is thoroughly revised and up to date with significant developments in the field, especially on the topic of innate immunity.

The Metabolic Challenges of Immune Cells in Health and Disease

The Metabolic Challenges of Immune Cells in Health and Disease
Author: Claudio Mauro,Christian Frezza
Publsiher: Unknown
Total Pages: 329
Release: 2015-07-13
ISBN 10: 2889196224
ISBN 13: 9782889196227
Language: EN, FR, DE, ES & NL

The Metabolic Challenges of Immune Cells in Health and Disease Book Review:

Obesity and its co-morbidities, including atherosclerosis, insulin resistance and diabetes, are a world-wide epidemic. Inflammatory immune responses in metabolic tissues have emerged as a universal feature of these metabolic disorders. While initial work highlighted the contribution of macrophages to tissue inflammation and insulin resistance, recent studies demonstrate that cells of the adaptive immune compartment, including T and B lymphocytes and dendritic cells also participate in obesity-induced pathogenesis of these conditions. However, the molecular and cellular pathways by which the innate and adaptive branches of immunity control tissue and systemic metabolism remain poorly understood. To engage in growth and activation, cells need to increase their biomass and replicate their genome. This process presents a substantial bioenergetic challenge: growing and activated cells must increase ATP production and acquire or synthesize raw materials, including lipids, proteins and nucleic acids. To do so, they actively reprogram their intracellular metabolism from catabolic mitochondrial oxidative phosphorylation to glycolysis and other anabolic pathways. This metabolic reprogramming is under the control of specific signal transduction pathways whose underlying molecular mechanisms and relevance to physiology and disease are subject of considerable current interest and under intense study. Recent reports have elucidated the physiological role of metabolic reprogramming in macrophage and T cell activation and differentiation, B- and dendritic cell biology, as well as in the crosstalk of immune cells with endothelial and stem cells. It is also becoming increasingly evident that alterations of metabolic pathways play a major role in the pathogenesis of chronic inflammatory disorders. Due to the scientific distance between immunologists and experts in metabolism (e.g., clinicians and biochemists), however, there has been limited cross-talk between these communities. This collection of articles aims at promoting such cross-talk and accelerating discoveries in the emerging field of immunometabolism.

Myeloid Cells in Health and Disease

Myeloid Cells in Health and Disease
Author: Siamon Gordon
Publsiher: John Wiley & Sons
Total Pages: 892
Release: 2020-07-10
ISBN 10: 1555819192
ISBN 13: 9781555819194
Language: EN, FR, DE, ES & NL

Myeloid Cells in Health and Disease Book Review:

The structure, functions, and interactions of myeloid cells have long been the focus of research and therapeutics development. Yet, much more remains to be discovered about the complex web of relationships that makes up the immune systems of animals. Scientists today are applying genome-wide analyses, single-cell methods, gene editing, and modern imaging techniques to reveal new subclasses of differentiated myeloid cells, new receptors and cytokines, and important interactions among immune cells. In Myeloid Cells in Health and Disease: A Synthesis, Editor Siamon Gordon has assembled an international team of esteemed scientists to provide their perspectives of myeloid cells during innate and adaptive immunity. The book begins by presenting the foundational research of Paul Ehrlich, Elie Metchnikoff, and Donald Metcalf. The following chapters discuss evolution and the life cycles of myeloid cells; specific types of differentiated myeloid cells, including macrophage differentiation; and antigen processing and presentation. The rest of the book is organized by broad topics in immunology, including the recruitment of myeloid and other immune cells following microbial infection the role of myeloid cells in the inflammation process and the repair of damaged tissue the vast arsenal of myeloid cell secretory molecules, including metalloproteinases, tumor necrosis factor, histamine, and perforin receptors and downstream signaling pathways that are activated following ligand-receptor binding roles of myeloid cells during microbial and parasite infections contributions of myeloid cells in atherosclerosis myeloid-derived suppressor cells in tumor development and cancer Myeloid Cells in Health and Disease: A Synthesis will benefit graduate students and researchers in immunology, hematology, microbial pathogenesis, infectious disease, pathology, and pharmacology. Established scientists and physicians in these and related fields will enjoy the book's rich history of myeloid cell research and suggestions for future research directions and potential therapies.

Adipose Tissue in Health and Disease

Adipose Tissue in Health and Disease
Author: Todd Leff,James G. Granneman
Publsiher: John Wiley & Sons
Total Pages: 530
Release: 2010-03-19
ISBN 10: 9783527629534
ISBN 13: 352762953X
Language: EN, FR, DE, ES & NL

Adipose Tissue in Health and Disease Book Review:

This timely and most comprehensive reference available on the topic covers all the different aspects vital in the fight against the global obesity epidemic. Following a look at adipose tissue development and morphology, the authors go on to examine its metabolic and endocrine functions and its role in disease. The final section deals with comparative and evolutionary aspects of the tissue. The result is an essential resource for cell and molecular biologists, physiologists, biochemists, pharmacologists, and those working in the pharmaceutical industry.

The Resolution of Inflammation

The Resolution of Inflammation
Author: Adriano Rossi,Deborah A. Sawatzky
Publsiher: Springer Science & Business Media
Total Pages: 240
Release: 2008-03-17
ISBN 10: 9783764375065
ISBN 13: 376437506X
Language: EN, FR, DE, ES & NL

The Resolution of Inflammation Book Review:

This book provides readers with an up-to-date and comprehensive view on the resolution of inflammation and on new developments in this area, including pro-resolution mediators, apoptosis, macrophage clearance of apoptotic cells, possible novel drug developments.

Translational Inflammation

Translational Inflammation
Author: Anonim
Publsiher: Academic Press
Total Pages: 294
Release: 2018-11-24
ISBN 10: 0128138335
ISBN 13: 9780128138335
Language: EN, FR, DE, ES & NL

Translational Inflammation Book Review:

Translational Inflammation links laboratory and clinical data within primary and secondary care to clinical research data and offers a holistic and innovative approach to chronic inflammation and ageing. Understanding the role of inflammation as a part of clinical disease states is becoming a valuable tool in both direct treatment and the development of therapeutics. Translational Inflammation, the 4th volume in the Perspectives in Translational Cell Biology series, offers content for professors, students and researchers across basic and translational biology. Emphasizes the role of inflammation in disease and therapeutic approaches Integrates broad concepts relating inflammation to other fields Offers a bridge to review literature and primary research on the inflammatory response towards medical application

Macrophage Pathogen Interactions

Macrophage Pathogen Interactions
Author: Bruce S. Zwilling
Publsiher: CRC Press
Total Pages: 664
Release: 1993-09-15
ISBN 10: 9780824791247
ISBN 13: 082479124X
Language: EN, FR, DE, ES & NL

Macrophage Pathogen Interactions Book Review:

This volume in the Immunology series examines the complex relationships between mononuclear phagocytes and the infectious agents that live and replicate within them, describing the basic characteristics of macrophages, including their differentiation, activation, antigen processing and presentation, and antimicrobial mechanisms. It provides information on pathogens associated with HIV infection such as mycobacterium tuberculosis, mycobacterium avium, candida albicans and pneumocystis carinii.

The Mononuclear Phagocyte System in Infectious Disease

The Mononuclear Phagocyte System in Infectious Disease
Author: Geanncarlo Lugo-Villarino,Céline Cougoule,Etienne Meunier,Yoann Rombouts,Christel Vérollet,Luciana Balboa
Publsiher: Frontiers Media SA
Total Pages: 329
Release: 2019-10-04
ISBN 10: 2889630579
ISBN 13: 9782889630578
Language: EN, FR, DE, ES & NL

The Mononuclear Phagocyte System in Infectious Disease Book Review:

The Mononuclear Phagocyte System (MPS) of vertebrates is composed of monocytes, macrophages and dendritic cells. Together, they form part of the first line of immune defense against a variety of pathogens (bacteria, fungi, parasites and viruses), and thus play an important role in maintaining organism homeostasis. The mode of transmission, type of replication and mechanism of disease-causing differ significantly for each pathogen, eliciting a unique immune response in the host. Within this context, the MPS acts as both the sentinel and tailor of the immune system. As sentinels, MPS cells are found in blood and within tissues throughout the body to patrol against pathogenic insult. The strategy to detect 'microbial non-self' relies on MPS to recognize conserved microbial products known as 'pathogen-associated molecular pattern' (PAMPs). PAMPs recognition represents a checkpoint in the response to pathogens and relies on conserved 'pattern recognition receptors' (PRRs). Upon PRR engagement, MPS mount a cell-autonomous attack that includes the internalization and compartmentalization of intracellular pathogens into toxic compartments that promote destruction. In parallel, MPS cells launch an inflammatory response composed of a cellular arm and soluble factors to control extracellular pathogens. In cases when innate immunity fails to eliminate the invading microbe, MPS serves as a tailor to generate adaptive immunity for pathogen eradication and generation of "memory" cells, thus ensuring enhanced protection against re-infection. Indeed, MPS cell functions comprise the capture, process, migration and delivery of antigenic information to lymphoid organs, where type-1 immunity is tailored against intracellular microbes and type-2 immunity against extracellular pathogens. However, this potent adaptive immunity is also a double-edge sword that can cause aberrant inflammatory disorders, like autoimmunity or chronic inflammation. For this reason, MPS also tailors tolerance immunity against unwanted inflammation. Successful clearance of the microbe results in its destruction and proper collection of debris, resolution of inflammation and tissue healing for which MPS is essential. Reciprocally, as part of the evolutionary process taking place in all organisms, microbes evolved strategies to circumvent the actions bestowed by MPS cells. Multiple pathogens modulate the differentiation, maturation and activation programs of the MPS, as an efficient strategy to avoid a dedicated immune response. Among the most common evasion strategies are the subversion of phagocytosis, inhibition of PRR-mediated immunity, resistance to intracellular killing by reactive oxygen and nitrogen species, restriction of phagosome maturation, modulation of cellular metabolism and nutrient acquisition, regulation of cell death and autophagy, and modulation of pro-inflammatory responses and hijacking of tolerance mechanisms, among others. The tenet of this eBook is that a better understanding of MPS in infection will yield insights for development of therapeutics to enhance antimicrobial processes or dampen detrimental inflammation for the host's benefit. We believe that contributions to this topic will serve as a platform for discussion and debate about relevant issues and themes in this field. Our aim is to bring expert junior and senior scientists to address recent progress, highlight critical knowledge gaps, foment scientific exchange, and establish conceptual frameworks for future MPS investigation in the context of infectious disease.

The Periodontal Ligament in Health and Disease

The Periodontal Ligament in Health and Disease
Author: B. K. B. Berkovitz,B. J. Moxham,Hubert N. Newman
Publsiher: Unknown
Total Pages: 446
Release: 1995
ISBN 10:
ISBN 13: UOM:39015034413107
Language: EN, FR, DE, ES & NL

The Periodontal Ligament in Health and Disease Book Review:

Immune Response Activation

Immune Response Activation
Author: Guy Huynh Thien Duc
Publsiher: BoD – Books on Demand
Total Pages: 276
Release: 2014-05-29
ISBN 10: 9535113747
ISBN 13: 9789535113744
Language: EN, FR, DE, ES & NL

Immune Response Activation Book Review:

The book Immune Response Activation is aiming to analyse the multifaceted aspects of the immune response, treating a number of representative cases in which the immune response is, on one hand, activated against pathogens, and, on the other hand, involved in pathologic settings, leading to allograft rejection, allergy and autoimmunity. The regulatory mechanisms in which the immune response can be modulated for rendering its effector components more efficient and/or not harmful to the organism is also dissected in translational purposes in cancer immunotherapy, local immunity against bacteria and viruses, as well as in allergy and autoimmunity.

Tumour Angiogenesis

Tumour Angiogenesis
Author: R. John Bicknell,Claire E. Lewis,Napoleone Ferrara
Publsiher: Unknown
Total Pages: 381
Release: 1997
ISBN 10:
ISBN 13: UOM:39015041324271
Language: EN, FR, DE, ES & NL

Tumour Angiogenesis Book Review:

Tumour Angiogenesis is the first comprehensive book to cover all areas of this rapidly expanding research area. Each chapter is written by world experts in the field and topics covered include in vivo models, mechanisms, inhibition, and the role of macrophages, cytokines, proteases,extracellular matrix components, nitric oxide, prostanoids and oncogenes/tumour suppressor genes in angiogenesis. Other chapters examine the role of specific growth factors in angiogenesis - these include vascular endothelial growth factor, the basic fibroblast growth factor family, transforminggrowth factor-beta, tumour necrosis factor-alpha, platelet-derived endothelial cell growth factor/thymidine phosphorylase and pleiotrophin and related molecules. Clinical issues are addressed in chapters that deal with the prognostic and predictive value of tumour microvessel density and thetherapeutic significance of microregional blood flow. The two final chapters examine the feasibility of targeting tumour vasculature using either antibodies or gene therapy.

Biology of Myelomonocytic Cells

Biology of Myelomonocytic Cells
Author: Anirban Ghosh
Publsiher: BoD – Books on Demand
Total Pages: 172
Release: 2017-05-10
ISBN 10: 9535131230
ISBN 13: 9789535131236
Language: EN, FR, DE, ES & NL

Biology of Myelomonocytic Cells Book Review:

Myelomonocytes are the multipotent cells in the stage of blood cell differentiation, which mainly comprise blood monocytes, tissue macrophages and subset of dendritic cells. Actually, their position and ability of judgement of the health of tissue or organ environment are the key initiators of tissue-specific immune response in a local and global fashion. Interestingly, the morpho-functional aspects of this group of cells vary to a wide range with their positional diversity. Their ability to communicate or represent the tissue microenvironment to the peripheral immune system and efficiency to engage the system to effector activation hold the key for a successful immune endeavour. The present volume shows some glimpses of such an extensive area of current immunology research.

Immunity and Inflammation in Health and Disease

Immunity and Inflammation in Health and Disease
Author: Shampa Chatterjee,Wolfgang Jungraithmayr,Debasis Bagchi
Publsiher: Academic Press
Total Pages: 476
Release: 2017-08-31
ISBN 10: 0128054026
ISBN 13: 9780128054024
Language: EN, FR, DE, ES & NL

Immunity and Inflammation in Health and Disease Book Review:

Immunity and Inflammation in Health and Disease: Emerging Roles of Nutraceuticals and Functional Foods in Immune Support provides a comprehensive description of the various pathways by which the vertebrate immune system works, the signals that trigger immune response and how fnew and novel nutraceuticals and functional foods, can be used to contain inflammation and also to boost immunity and immune health. Inflammation is a tool to fight pathogens and the vertebrate immune system has a very complex network of cells to achieve this. However inflammation that goes awry is also the leding cause of several diseases ranging from cardiovascular diseases to diabetes. This book covers the entire gamut from the various cellular players in the inflammation-immune response to its ramifications in terms of protection against pathogens as well as in onset of metabolic, aging and auto-immune related diseases. Finally, the balancing role of dietary nutrients between host defence and immune support is also showcased. The first three scetions explain the various components of the immune system and their modes of activation. The fourth section deals with the ramifications of a robust and execessive inflammatory response. The fifth section is focused on the association between nutrition and immunity and how deficiencies in certain nutrients may affect immunocompetence. The sixth section chapters represent a vision of paradigm shifts within the field and discusses possible future directions. This bool will be a valuable reference for researchers studying immune health either in academia, or in the nutraceutical or functional food industries. Product developers in nutraceutical, supplement, functional food, and health food companies will also appreciate the information presented here. Conceptualizes the key features in natural products which can boost immune function and immune health Explains the intricate mechanistic aspects and balance behind immune health Presents the pathophysiology of several diseases associated with immune system disruption

The Biology of Subcellular Nitric Oxide

The Biology of Subcellular Nitric Oxide
Author: Tamás Rőszer
Publsiher: Springer Science & Business Media
Total Pages: 210
Release: 2012-01-14
ISBN 10: 9400728190
ISBN 13: 9789400728196
Language: EN, FR, DE, ES & NL

The Biology of Subcellular Nitric Oxide Book Review:

This book fills in a gap in the NO literature. Recent progress in the field of NO-biology shows that NO is generated within distinct cell compartments, including specific plasma membrane regions, mitochondria, chloroplasts, peroxisomes, the Golgi-complex and intracellular membrane systems. NO synthesis plays specific roles in these compartments and, in turn, cell organelles also control intracellular NO levels. This monograph focuses on the roles played by the subcellular NO-signaling microdomains in the prokaryote-, fungus-, plant- and animal cells and shows how NO behaves as an intracellular signal in distinct cellular environments. This monograph also provides a summary of our knowledge on how NO synthesis came through evolution to be associated with organelles and subcellular compartments. Promotes the novel ideas that some functions of NO and its associations with subcellular units have been conserved during the evolution of the cell. A special chapter is dedicated to the biomedical relevance of subcellular NO synthesis, and this chapter also discusses the evidence that altered compartmentalization of NO-producing enzymes causes disease.

Muscle Cell and Tissue

Muscle Cell and Tissue
Author: Kunihiro Sakuma
Publsiher: BoD – Books on Demand
Total Pages: 486
Release: 2015-09-02
ISBN 10: 9535121561
ISBN 13: 9789535121565
Language: EN, FR, DE, ES & NL

Muscle Cell and Tissue Book Review:

In order to complete tissue regeneration, various cells such as neuronal, skeletal, smooth, endothelial, and immune (e.g., macrophage) interact smoothly with each other. This book, Muscle Cells and Tissues, offers a wide range of topics such as stem cells, cell culture, biomaterials, epigenetics, therapeutics, and the creation of tissues and organs. Novel applications for cell and tissue engineering including cell therapy, tissue models, and disease pathology modeling are discussed. The book also deals with the functional role of autophagy in modulating muscle homeostasis and molecular mechanism regulating skeletal muscle mass. The chapters can be interesting for graduate students, postdocs, teachers, physicians, and for executives in biotech and pharmaceutical companies, as well as researchers in the fields of molecular biology and regenerative medicine.

Chronic Liver Failure

Chronic Liver Failure
Author: Pere Ginès,Patrick S Kamath,Vicente Arroyo
Publsiher: Springer Science & Business Media
Total Pages: 590
Release: 2010-11-03
ISBN 10: 9781607618669
ISBN 13: 1607618664
Language: EN, FR, DE, ES & NL

Chronic Liver Failure Book Review:

Chronic liver failure is a frequent condition in clinical practice that encompasses all manifestations of patients with end-stage liver diseases. Chronic liver failure is a multiorgan syndrome that affects the liver, kidneys, brain, heart, lungs, adrenal glands, and vascular, coagulation, and immune systems. Chronic Liver Failure: Mechanisms and Management covers for the first time all aspects of chronic liver failure in a single book, from pathogenesis to current management. Each chapter is written by a worldwide known expert in their area and all provide the latest state-of-the-art knowledge. This volume is specifically designed to provide answers to clinical questions to all doctors dealing with patients with liver diseases, not only clinical gastroenterologists and hepatologists, but also to internists, nephrologists, intensive care physicians, and transplant surgeons.

Immunobiology 5 the Immune System in Health and Disease

Immunobiology 5   the Immune System in Health and Disease
Author: Charles Janeway,Paul Travers,Mark Walport,Mark Schlomchik
Publsiher: Garland Science
Total Pages: 732
Release: 2001
ISBN 10: 9780815336426
ISBN 13: 081533642X
Language: EN, FR, DE, ES & NL

Immunobiology 5 the Immune System in Health and Disease Book Review:

Designed for providers who work with judicial clients, the Providers Guide presents effective cognitive-behavioral treatment approaches. The Second Edition of this bestseller unveils a state-of-the-art approach for effectively preventing criminal recidivism and substance abuse relapse within community based and correctional settings. The core of the SSC program is a positive relationship between provider and client. Summary of results survey from the first edition of SSC 95% of the providers rated the components of SSC to be adequate to very adequate in meeting the treatment needs of judicial clients Over 90% of providers rated clients as having a moderate to very high involvement in homework and reading 95% of the clients rates as very high their satisfaction of SSC delivery, the provider's response to client needs and clients' comfort with providers Around 80% of clients reported their cognitive and behavioral control over AOD use and criminal conduct had improved during SSC The accompanying Participant's Workbook to the SSC is written to engage clients and encourage active participation in treatment and responsible living: Phase I: Challenge to Change: Building Knowledge and Skills for Responsible Living Phase II: Commitment to Change: Strengthening Skills for Self-Improvement, Change, and Responsible Living Phase III: Taking Ownership of Change: Lifestyle Balance and Healthy Living

Innovative Medicine

Innovative Medicine
Author: Kazuwa Nakao,Nagahiro Minato,Shinji Uemoto
Publsiher: Springer
Total Pages: 339
Release: 2015-10-13
ISBN 10: 4431556516
ISBN 13: 9784431556510
Language: EN, FR, DE, ES & NL

Innovative Medicine Book Review:

This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.