Macrophages Biology and Tissue Inflammation in Health and Disease

Macrophages Biology and Tissue Inflammation in Health and Disease
Author: Stuart Goodman,Michiaki Takagi,Jiri Gallo
Publsiher: Academic Press
Total Pages: 366
Release: 2021-09-01
ISBN 10: 0128217626
ISBN 13: 9780128217627
Language: EN, FR, DE, ES & NL

Macrophages Biology and Tissue Inflammation in Health and Disease Book Review:

Macrophages Biology and Tissue Inflammation in Health and Disease, outlines the important role of macrophages, keys cells in the innate immune system, as regulators and orchestrators of inflammation and repair in health and disease. It contains chapters by leading authors on the basic and translational aspects of macrophage biology, in maintaining tissue homeostatis and dealing with internal and external biological threats. Outlines the important role of macrophages, key cells in the innatue immune system, as regulators and orchestrators of inflammation and repair in health and disease Contains chapters by leading authors on the basic and translational aspects of macrophage biology, in maintaining tissue homeostasis Deals with internal and external treats.

Macrophages Biology and Role in the Pathology of Diseases

Macrophages  Biology and Role in the Pathology of Diseases
Author: Subhra K. Biswas,Alberto Mantovani
Publsiher: Springer
Total Pages: 615
Release: 2014-11-12
ISBN 10: 1493913115
ISBN 13: 9781493913114
Language: EN, FR, DE, ES & NL

Macrophages Biology and Role in the Pathology of Diseases Book Review:

Macrophages are a key component of the innate immune system and play an integral role in host defense and homeostasis. On one hand, these cells contribute to host defence by triggering inflammation, displaying microbicidal/tumoricidal properties, regulating the activation of adaptive immunity and promoting resolution of inflammation. On the other hand, they contribute to essential trophic functions such as neural patterning, bone morphogenesis and ductal branching in mammary glands. Thus, macrophages are extremely versatile cells that can respond efficiently to tissue micro environmental cues by polarizing to distinct phenotypes, depending on the functions they need to perform. Indeed, functional diversity and plasticity are hallmarks of these cells. Macrophages may also play a detrimental role. An overwhelming body of literature has indicated their crucial role in pathogenesis. The list includes sepsis, cancer, metabolic syndrome, immunodeficiency, auto-immune disease-virtually impacting every major pathology that we know. These observations have suggested macrophages and their related molecules as potential targets in therapeutic applications. Available evidence proclaims macrophages as a key player in homeostasis, host defense and disease. Crucial developments in the past few years call for a re-evaluation and update of our understanding of macrophages. The present book is an endeavour that attempts provide state-of-the art knowledge of these cells in health and disease.

M1 M2 Macrophages The Arginine Fork in the Road to Health and Disease

M1 M2 Macrophages  The Arginine Fork in the Road to Health and Disease
Author: Charles Dudley Mills,Laurel L Lenz,Klaus Ley
Publsiher: Frontiers Media SA
Total Pages: 280
Release: 2015-03-23
ISBN 10: 288919499X
ISBN 13: 9782889194995
Language: EN, FR, DE, ES & NL

M1 M2 Macrophages The Arginine Fork in the Road to Health and Disease Book Review:

Macrophages have unique and diverse functions necessary for survival. And, in humans (and other species), they are the most abundant leukocytes in tissues. The Innate functions of macrophages that are best known are their unusual ability to either “Kill” or “Repair”. Since killing is a destructive process and repair is a constructive process, it was stupefying how one cell could exhibit these 2 polar – opposite functions. However, in the late 1980’s, it was shown that macrophages have a unique ability to enzymatically metabolize Arginine to Nitric Oxide (NO, a gaseous non – specific killer molecule) or to Ornithine (a precursor of polyamines and collagen for repair). The dual Arginine metabolic capacity of macrophages provided a functional explanation for their ability to kill or repair. Macrophages predominantly producing NO are called M1 and those producing Ornithine are called M2. M1 and M2 – dominant responses occur in lower vertebrates, and in T cell deficient vertebrates being directly driven by Damage and Pathogen Associated Molecular Patterns (DAMP and PAMP). Thus, M1 and M2 are Innate responses that protect the host without Adaptive Immunity. In turn, M1/M2 is supplanting previous models in which T cells were necessary to “activate” or “alternatively activate” macrophages (the Th1/Th2 paradigm). M1 and M2 macrophages were named such because of the additional key findings that these macrophages stimulate Th1 and Th2 – like responses, respectively. So, in addition to their unique ability to kill or repair, macrophages also govern Adaptive Immunity. All of the foregoing would be less important if M1 or M2 – dominant responses were not observed in disease. But, they are. The best example to date is the predominance of M2 macrophages in human tumors where they act like wound repair macrophages and actively promote growth. More generally, humans have become M2 – dominant because sanitation, antibiotics and vaccines have lessened M1 responses. And, M2 dominance seems the cause of ever - increasing allergies in developed countries. Obesity represents a new and different circumstance. Surfeit energy (e.g., lipoproteins) causes monocytes to become M1 dominant in the vessel walls causing plaques. Because M1 or M2 dominant responses are clearly causative in many modern diseases, there is great potential in developing the means to selectively stimulate (or inhibit) either M1 or M2 responses to kill or repair, or to stimulate Th1 or Th2 responses, depending on the circumstance. The contributions here are meant to describe diseases of M1 or M2 dominance, and promising new methodologies to modulate the fungible metabolic machinery of macrophages for better health.

Immunobiology

Immunobiology
Author: Charles Janeway,Paul Travers
Publsiher: Taylor & Francis
Total Pages: 590
Release: 1994
ISBN 10: 9780815316916
ISBN 13: 0815316917
Language: EN, FR, DE, ES & NL

Immunobiology Book Review:

Immunobiology tells the story of the immune system. The book covers all of the material that comprises a typical immunology course. The Fifth Edition is an extensive revision which includes new material and major insights, improved logical progression of topics, and an emphasis on unifying principles. With clear, concise text and a full-color art program, this book continues to set the standard for a current and authoritative immunology textbook. Copyright © Libri GmbH. All rights reserved.

The Metabolic Challenges of Immune Cells in Health and Disease

The Metabolic Challenges of Immune Cells in Health and Disease
Author: Claudio Mauro,Christian Frezza
Publsiher: Unknown
Total Pages: 329
Release: 2015-07-13
ISBN 10: 2889196224
ISBN 13: 9782889196227
Language: EN, FR, DE, ES & NL

The Metabolic Challenges of Immune Cells in Health and Disease Book Review:

Obesity and its co-morbidities, including atherosclerosis, insulin resistance and diabetes, are a world-wide epidemic. Inflammatory immune responses in metabolic tissues have emerged as a universal feature of these metabolic disorders. While initial work highlighted the contribution of macrophages to tissue inflammation and insulin resistance, recent studies demonstrate that cells of the adaptive immune compartment, including T and B lymphocytes and dendritic cells also participate in obesity-induced pathogenesis of these conditions. However, the molecular and cellular pathways by which the innate and adaptive branches of immunity control tissue and systemic metabolism remain poorly understood. To engage in growth and activation, cells need to increase their biomass and replicate their genome. This process presents a substantial bioenergetic challenge: growing and activated cells must increase ATP production and acquire or synthesize raw materials, including lipids, proteins and nucleic acids. To do so, they actively reprogram their intracellular metabolism from catabolic mitochondrial oxidative phosphorylation to glycolysis and other anabolic pathways. This metabolic reprogramming is under the control of specific signal transduction pathways whose underlying molecular mechanisms and relevance to physiology and disease are subject of considerable current interest and under intense study. Recent reports have elucidated the physiological role of metabolic reprogramming in macrophage and T cell activation and differentiation, B- and dendritic cell biology, as well as in the crosstalk of immune cells with endothelial and stem cells. It is also becoming increasingly evident that alterations of metabolic pathways play a major role in the pathogenesis of chronic inflammatory disorders. Due to the scientific distance between immunologists and experts in metabolism (e.g., clinicians and biochemists), however, there has been limited cross-talk between these communities. This collection of articles aims at promoting such cross-talk and accelerating discoveries in the emerging field of immunometabolism.

The Resolution of Inflammation

The Resolution of Inflammation
Author: Adriano Rossi,Deborah A. Sawatzky
Publsiher: Springer Science & Business Media
Total Pages: 240
Release: 2008-03-17
ISBN 10: 9783764375065
ISBN 13: 376437506X
Language: EN, FR, DE, ES & NL

The Resolution of Inflammation Book Review:

This book provides readers with an up-to-date and comprehensive view on the resolution of inflammation and on new developments in this area, including pro-resolution mediators, apoptosis, macrophage clearance of apoptotic cells, possible novel drug developments.

Myeloid Cells in Health and Disease

Myeloid Cells in Health and Disease
Author: Siamon Gordon
Publsiher: John Wiley & Sons
Total Pages: 892
Release: 2020-07-10
ISBN 10: 1555819192
ISBN 13: 9781555819194
Language: EN, FR, DE, ES & NL

Myeloid Cells in Health and Disease Book Review:

The structure, functions, and interactions of myeloid cells have long been the focus of research and therapeutics development. Yet, much more remains to be discovered about the complex web of relationships that makes up the immune systems of animals. Scientists today are applying genome-wide analyses, single-cell methods, gene editing, and modern imaging techniques to reveal new subclasses of differentiated myeloid cells, new receptors and cytokines, and important interactions among immune cells. In Myeloid Cells in Health and Disease: A Synthesis, Editor Siamon Gordon has assembled an international team of esteemed scientists to provide their perspectives of myeloid cells during innate and adaptive immunity. The book begins by presenting the foundational research of Paul Ehrlich, Elie Metchnikoff, and Donald Metcalf. The following chapters discuss evolution and the life cycles of myeloid cells; specific types of differentiated myeloid cells, including macrophage differentiation; and antigen processing and presentation. The rest of the book is organized by broad topics in immunology, including the recruitment of myeloid and other immune cells following microbial infection the role of myeloid cells in the inflammation process and the repair of damaged tissue the vast arsenal of myeloid cell secretory molecules, including metalloproteinases, tumor necrosis factor, histamine, and perforin receptors and downstream signaling pathways that are activated following ligand-receptor binding roles of myeloid cells during microbial and parasite infections contributions of myeloid cells in atherosclerosis myeloid-derived suppressor cells in tumor development and cancer Myeloid Cells in Health and Disease: A Synthesis will benefit graduate students and researchers in immunology, hematology, microbial pathogenesis, infectious disease, pathology, and pharmacology. Established scientists and physicians in these and related fields will enjoy the book's rich history of myeloid cell research and suggestions for future research directions and potential therapies.

Adipose Tissue in Health and Disease

Adipose Tissue in Health and Disease
Author: Todd Leff,James G. Granneman
Publsiher: John Wiley & Sons
Total Pages: 530
Release: 2010-03-19
ISBN 10: 9783527629534
ISBN 13: 352762953X
Language: EN, FR, DE, ES & NL

Adipose Tissue in Health and Disease Book Review:

This timely and most comprehensive reference available on the topic covers all the different aspects vital in the fight against the global obesity epidemic. Following a look at adipose tissue development and morphology, the authors go on to examine its metabolic and endocrine functions and its role in disease. The final section deals with comparative and evolutionary aspects of the tissue. The result is an essential resource for cell and molecular biologists, physiologists, biochemists, pharmacologists, and those working in the pharmaceutical industry.

The Periodontal Ligament in Health and Disease

The Periodontal Ligament in Health and Disease
Author: B. K. B. Berkovitz,B. J. Moxham,Hubert N. Newman
Publsiher: Unknown
Total Pages: 446
Release: 1995
ISBN 10:
ISBN 13: UOM:39015034413107
Language: EN, FR, DE, ES & NL

The Periodontal Ligament in Health and Disease Book Review:

Lung Macrophages in Health and Disease

Lung Macrophages in Health and Disease
Author: Sandra Hodge
Publsiher: Bentham Science Publishers
Total Pages: 120
Release: 2009-09-12
ISBN 10: 1608050203
ISBN 13: 9781608050208
Language: EN, FR, DE, ES & NL

Lung Macrophages in Health and Disease Book Review:

"This Ebook is edited by Sandra Hodge, a recognized expert in the field of macrophage dysfunction in chronic lung disease. The book consists of 8 chapters which provide a full coverage of macrophage function in both healthy and chronically diseased lungs, "

Immunity and Inflammation in Health and Disease

Immunity and Inflammation in Health and Disease
Author: Shampa Chatterjee,Wolfgang Jungraithmayr,Debasis Bagchi
Publsiher: Academic Press
Total Pages: 476
Release: 2017-08-31
ISBN 10: 0128054026
ISBN 13: 9780128054024
Language: EN, FR, DE, ES & NL

Immunity and Inflammation in Health and Disease Book Review:

Immunity and Inflammation in Health and Disease: Emerging Roles of Nutraceuticals and Functional Foods in Immune Support provides a comprehensive description of the various pathways by which the vertebrate immune system works, the signals that trigger immune response and how fnew and novel nutraceuticals and functional foods, can be used to contain inflammation and also to boost immunity and immune health. Inflammation is a tool to fight pathogens and the vertebrate immune system has a very complex network of cells to achieve this. However inflammation that goes awry is also the leding cause of several diseases ranging from cardiovascular diseases to diabetes. This book covers the entire gamut from the various cellular players in the inflammation-immune response to its ramifications in terms of protection against pathogens as well as in onset of metabolic, aging and auto-immune related diseases. Finally, the balancing role of dietary nutrients between host defence and immune support is also showcased. The first three scetions explain the various components of the immune system and their modes of activation. The fourth section deals with the ramifications of a robust and execessive inflammatory response. The fifth section is focused on the association between nutrition and immunity and how deficiencies in certain nutrients may affect immunocompetence. The sixth section chapters represent a vision of paradigm shifts within the field and discusses possible future directions. This bool will be a valuable reference for researchers studying immune health either in academia, or in the nutraceutical or functional food industries. Product developers in nutraceutical, supplement, functional food, and health food companies will also appreciate the information presented here. Conceptualizes the key features in natural products which can boost immune function and immune health Explains the intricate mechanistic aspects and balance behind immune health Presents the pathophysiology of several diseases associated with immune system disruption

Translational Inflammation

Translational Inflammation
Author: Anonim
Publsiher: Academic Press
Total Pages: 294
Release: 2018-11-24
ISBN 10: 0128138335
ISBN 13: 9780128138335
Language: EN, FR, DE, ES & NL

Translational Inflammation Book Review:

Translational Inflammation links laboratory and clinical data within primary and secondary care to clinical research data and offers a holistic and innovative approach to chronic inflammation and ageing. Understanding the role of inflammation as a part of clinical disease states is becoming a valuable tool in both direct treatment and the development of therapeutics. Translational Inflammation, the 4th volume in the Perspectives in Translational Cell Biology series, offers content for professors, students and researchers across basic and translational biology. Emphasizes the role of inflammation in disease and therapeutic approaches Integrates broad concepts relating inflammation to other fields Offers a bridge to review literature and primary research on the inflammatory response towards medical application

Biology of Myelomonocytic Cells

Biology of Myelomonocytic Cells
Author: Anirban Ghosh
Publsiher: BoD – Books on Demand
Total Pages: 172
Release: 2017-05-10
ISBN 10: 9535131230
ISBN 13: 9789535131236
Language: EN, FR, DE, ES & NL

Biology of Myelomonocytic Cells Book Review:

Myelomonocytes are the multipotent cells in the stage of blood cell differentiation, which mainly comprise blood monocytes, tissue macrophages and subset of dendritic cells. Actually, their position and ability of judgement of the health of tissue or organ environment are the key initiators of tissue-specific immune response in a local and global fashion. Interestingly, the morpho-functional aspects of this group of cells vary to a wide range with their positional diversity. Their ability to communicate or represent the tissue microenvironment to the peripheral immune system and efficiency to engage the system to effector activation hold the key for a successful immune endeavour. The present volume shows some glimpses of such an extensive area of current immunology research.

Neutrophils

Neutrophils
Author: Maitham Khajah
Publsiher: BoD – Books on Demand
Total Pages: 98
Release: 2019-02-06
ISBN 10: 1789852854
ISBN 13: 9781789852851
Language: EN, FR, DE, ES & NL

Neutrophils Book Review:

This book highlights the numerous important properties of neutrophils and their role in various diseases, and as a possible therapeutic target as well. The first chapter briefly discusses the main effector neutrophil functions, which is followed by two chapters discussing the importance of different neutrophil receptors (cannabinoid and Fc?R) and their role in various disease conditions. The fourth chapter discusses the differential expression profile of CD16+CD11b+ on the surface of neutrophils as a tool for the diagnosis of acute infections. The last chapter discusses the physics of the NADPH oxidase system and the use of different chemiluminigenic probes for the detection of various reactive oxygen intermediates of the circulating neutrophils.

Immunobiology 5 the Immune System in Health and Disease

Immunobiology 5   the Immune System in Health and Disease
Author: Charles Janeway,Paul Travers,Mark Walport,Mark Schlomchik
Publsiher: Garland Science
Total Pages: 732
Release: 2001
ISBN 10: 9780815336426
ISBN 13: 081533642X
Language: EN, FR, DE, ES & NL

Immunobiology 5 the Immune System in Health and Disease Book Review:

Designed for providers who work with judicial clients, the Providers Guide presents effective cognitive-behavioral treatment approaches. The Second Edition of this bestseller unveils a state-of-the-art approach for effectively preventing criminal recidivism and substance abuse relapse within community based and correctional settings. The core of the SSC program is a positive relationship between provider and client. Summary of results survey from the first edition of SSC 95% of the providers rated the components of SSC to be adequate to very adequate in meeting the treatment needs of judicial clients Over 90% of providers rated clients as having a moderate to very high involvement in homework and reading 95% of the clients rates as very high their satisfaction of SSC delivery, the provider's response to client needs and clients' comfort with providers Around 80% of clients reported their cognitive and behavioral control over AOD use and criminal conduct had improved during SSC The accompanying Participant's Workbook to the SSC is written to engage clients and encourage active participation in treatment and responsible living: Phase I: Challenge to Change: Building Knowledge and Skills for Responsible Living Phase II: Commitment to Change: Strengthening Skills for Self-Improvement, Change, and Responsible Living Phase III: Taking Ownership of Change: Lifestyle Balance and Healthy Living

Complement in Health and Disease

Complement in Health and Disease
Author: K. Whaley
Publsiher: Springer
Total Pages: 352
Release: 1987-03-31
ISBN 10: 9780852009543
ISBN 13: 0852009542
Language: EN, FR, DE, ES & NL

Complement in Health and Disease Book Review:

'The extensive subject index with about 400 entries makes the book easy to use for fast access to information. An excellent book' Karger, Vol. 5, No. 2, 1988

Research Awards Index

Research Awards Index
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 1983
ISBN 10:
ISBN 13: STANFORD:36105119624737
Language: EN, FR, DE, ES & NL

Research Awards Index Book Review:

Macrophages

Macrophages
Author: Malgorzata Kloc
Publsiher: Springer
Total Pages: 376
Release: 2017-04-26
ISBN 10: 3319540904
ISBN 13: 9783319540900
Language: EN, FR, DE, ES & NL

Macrophages Book Review:

This volume gives a state-of-the-art overview on macrophage functions in various invertebrate and vertebrate systems and diseases. It also covers various aspects of macrophage development and formation, behavior and response to nano- and biomaterials, the latter of which have become very important components of modern medicine. Macrophages are evolutionarily conserved phagocytotic cells. In recent years macrophages have emerged as one of the most versatile cells of immune system, which, depending on the milieu and circumstance, participate in development or inhibition of cancer, regeneration, wound healing, inflammation, organ rejection and interaction between mother and a fetus. This book will be of particular interest to researchers working in immunology, cancer research, developmental biology, or related fields.

Oxidative Stress Inflammation and Health

Oxidative Stress  Inflammation  and Health
Author: Young-Joon Surh
Publsiher: CRC Press
Total Pages: 660
Release: 2005-05-24
ISBN 10: 1420028251
ISBN 13: 9781420028256
Language: EN, FR, DE, ES & NL

Oxidative Stress Inflammation and Health Book Review:

Specifically focusing on the redox regulation of cell signaling responsible for oxidative stress and inflammatory tissue damage, this reference provides a comprehensive overview of cutting-edge research on the intracellular events mediating or preventing oxidative stress and pro-inflammatory processes induced by endogenous and xenobiotic factors-analyzing the implications of oxidative stress and inflammatory damage in the pathogenesis of human disorders such as cancer, neurodegenerative disease, and diabetes.

Immune Response Activation

Immune Response Activation
Author: Guy Huynh Thien Duc
Publsiher: BoD – Books on Demand
Total Pages: 276
Release: 2014-05-29
ISBN 10: 9535113747
ISBN 13: 9789535113744
Language: EN, FR, DE, ES & NL

Immune Response Activation Book Review:

The book Immune Response Activation is aiming to analyse the multifaceted aspects of the immune response, treating a number of representative cases in which the immune response is, on one hand, activated against pathogens, and, on the other hand, involved in pathologic settings, leading to allograft rejection, allergy and autoimmunity. The regulatory mechanisms in which the immune response can be modulated for rendering its effector components more efficient and/or not harmful to the organism is also dissected in translational purposes in cancer immunotherapy, local immunity against bacteria and viruses, as well as in allergy and autoimmunity.