Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease

Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease
Author: Venkataramana K Sidhaye,Michael Koval
Publsiher: Academic Press
Total Pages: 276
Release: 2017-03-09
ISBN 10: 0128038810
ISBN 13: 9780128038819
Language: EN, FR, DE, ES & NL

Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease Book Review:

Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease provides a one-stop resource capturing developments in lung epithelial biology related to basic physiology, pathophysiology, and links to human disease. The book provides access to knowledge of molecular and cellular aspects of lung homeostasis and repair, including the molecular basis of lung epithelial intercellular communication and lung epithelial channels and transporters. Also included is coverage of lung epithelial biology as it relates to fluid balance, basic ion/fluid molecular processes, and human disease. Useful to physician and clinical scientists, the contents of this book compile the important and most current findings about the role of epithelial cells in lung disease. Medical and graduate students, postdoctoral and clinical fellows, as well as clinicians interested in the mechanistic basis for lung disease will benefit from the books examination of principles of lung epithelium functions in physiological condition. Provides a single source of information on lung epithelial junctions and transporters Discusses of the role of the epithelium in lung homeostasis and disease Includes capsule summaries of main conclusions as well as highlights of future directions in the field Covers the mechanistic basis for lung disease for a range of audiences

How Tobacco Smoke Causes Disease

How Tobacco Smoke Causes Disease
Author: U. s. Department of Health and Human Services Staff
Publsiher: U.S. Government Printing Office
Total Pages: 704
Release: 2010
ISBN 10: 1928374650XXX
ISBN 13: UCSD:31822037817723
Language: EN, FR, DE, ES & NL

How Tobacco Smoke Causes Disease Book Review:

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Idiopathic Pulmonary Fibrosis

Idiopathic Pulmonary Fibrosis
Author: Joseph P. Lynch
Publsiher: CRC Press
Total Pages: 800
Release: 2003-12-18
ISBN 10: 0203913442
ISBN 13: 9780203913444
Language: EN, FR, DE, ES & NL

Idiopathic Pulmonary Fibrosis Book Review:

A discussion of the epidemiology, clinical features, and differential diagnoses of idiopathic pulmonary fibrosis (IPF). Key topics include the role of polymorphonuclear leukocytes in the pathogenesis of pulmonary fibrosis, and current treatment options, including medical therapy and lung transplantation.

Cell Interaction

Cell Interaction
Author: Bhawana Singh
Publsiher: BoD – Books on Demand
Total Pages: 228
Release: 2021-04-07
ISBN 10: 183968416X
ISBN 13: 9781839684166
Language: EN, FR, DE, ES & NL

Cell Interaction Book Review:

This book discusses contemporary ideas on different molecular and immunological aspects of diseases. Different signaling mediators drive the production of messenger molecules that mediate their action, leading to the elicitation/suppression of immune responses. It provides a balanced approach to the study of different molecular phenomena that eventually drive infection outcomes and that can be manipulated for therapeutic benefits.

Mustard Lung

Mustard Lung
Author: Mostafa Ghanei,Ali Amini Harandi
Publsiher: Academic Press
Total Pages: 162
Release: 2016-05-03
ISBN 10: 0128039795
ISBN 13: 9780128039793
Language: EN, FR, DE, ES & NL

Mustard Lung Book Review:

Mustard Lung: Diagnosis and Treatment of Respiratory Disorders in Sulfur-Mustard Injured Patients brings together the details regarding pathophysiology, medication, and protective issues to provide a comprehensive look at health problems associated with sulfur mustard injury. It provides a bench-to-bedside look at the long term complications of vesicant exposure in humans as well as how mustard gas exposure affects lung function. By providing guidelines and approaches for the diagnosis, pathogenesis, and treatment of SM injury cases, this book is helpful for a wide range of medical researchers and clinicians. For decades, chemical respiratory disorders were diagnosed and managed traditionally similar to other chronic respiratory diseases. However, the exact nature of chemical respiratory disorders is different and needs to be treated as such. Includes the most up-to-date basic and clinical research findings on sulfur mustard from top researchers Provides information on chemical agents, complications that arise due to sulfur mustard exposure, and drugs available to treat injuries Contains an appendix with practical prescription recommendations for patients affected by mustard lung Provides a bench-to-bedside look at the long term complications of vesicant exposure in humans as well as how mustard gas exposure affects lung function

Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems

Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems
Author: Kamal Dua,Philip M. Hansbro,Ridhima Wadhwa,Mehra Haghi,Lisa G. Pont,Kylie A. Williams
Publsiher: Academic Press
Total Pages: 616
Release: 2020-08-04
ISBN 10: 0128208880
ISBN 13: 9780128208885
Language: EN, FR, DE, ES & NL

Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems Book Review:

Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems explores the development of novel therapeutics and diagnostics to improve pulmonary disease management, looking down to the nanoscale level for an efficient system of targeting and managing respiratory disease. The book examines numerous nanoparticle-based drug systems such as nanocrystals, dendrimers, polymeric micelles, protein-based, carbon nanotube, and liposomes that can offer advantages over traditional drug delivery systems. Starting with a brief introduction on different types of nanoparticles in respiratory disease conditions, the book then focuses on current trends in disease pathology that use different in vitro and in vivo models. The comprehensive resource is designed for those new to the field and to specialized scientists and researchers involved in pulmonary research and drug development. Explores recent perspectives and challenges regarding the management and diagnosis of chronic respiratory diseases Provides insights into how advanced drug delivery systems can be effectively formulated and delivered for the management of various pulmonary diseases Includes the most recent information on diagnostic methods and treatment strategies using controlled drug delivery systems (including nanotechnology)

Cystic Fibrosis

Cystic Fibrosis
Author: Dennis Wat,Dilip Nazareth
Publsiher: BoD – Books on Demand
Total Pages: 136
Release: 2020-07-08
ISBN 10: 1789841453
ISBN 13: 9781789841459
Language: EN, FR, DE, ES & NL

Cystic Fibrosis Book Review:

Cystic Fibrosis - Heterogeneity and Personalized Treatment provides the latest research and clinical evidence for clinicians, scientists and researchers involved in the care of patients with cystic fibrosis (CF). This book outlines the burden of the CF microbiome, utilisation of CF registries to impact future care, the sequelae of hepatobiliary complication, the use of upcoming technologies to provide patient-centred care, and provides an overview of cystic fibrosis transmembrane regulator (CFTR) modulators. Looking after patients with CF is highly rewarding, allowing those of us to combine our dedication and problem-solving skills to create a personalized approach. This book is invaluable for those involved in the care of CF patients.

Lung Stem Cells in Development Health and Disease

Lung Stem Cells in Development  Health and Disease
Author: Nikolic, Marko Z.,Hogan, Brigid L.M.
Publsiher: European Respiratory Society
Total Pages: 392
Release: 2021-04-01
ISBN 10: 1849841349
ISBN 13: 9781849841344
Language: EN, FR, DE, ES & NL

Lung Stem Cells in Development Health and Disease Book Review:

Most organs in the adult human body are able to maintain themselves and undergo repair after injury; these processes are largely dependent on stem cells. In this Monograph, the Guest Editors bring together leading authors in the field to provide information about the different classes of stem cells present both in the developing and adult lung: where they are found, how they function in homeostasis and pathologic conditions, the mechanisms that regulate their behaviour, and how they may be harnessed for therapeutic purposes. The book focuses on stem cells in the mouse and human lung but also includes the ferret as an increasingly important new model organism. Chapters also discuss how lung tissue, including endogenous stem cells, can be generated in vitro from pluripotent stem cell lines. This state-of-the-art collection comprehensively covers one of the most exciting areas of respiratory science

Self Organizing Nanovectors for Drug Delivery

Self Organizing Nanovectors for Drug Delivery
Author: Giuseppe De Rosa,Pietro Matricardi
Publsiher: MDPI
Total Pages: 186
Release: 2020-04-17
ISBN 10: 3039284282
ISBN 13: 9783039284283
Language: EN, FR, DE, ES & NL

Self Organizing Nanovectors for Drug Delivery Book Review:

Nanomedicine represents one of the most investigated areas in the last two decades in the field of pharmaceutics. Several nanovectors have been developed and a growing number of products have been approved. It is well known that many biomaterials are able to self-organize under controlled conditions giving rise nanostructures. Polymers, lipids, inorganic materials, peptides and proteins, and surfactants are examples of such biomaterials and the self-assembling property can be exploited to design nanovectors that are useful for drug delivery. The self-organization of nanostructures is an attractive approach to preparing nanovectors, avoiding complex and high-energy-consuming preparation methods, and, in some cases, facilitating drug loading procedures. Moreover, preparations based on these biocompatible and pharmaceutical grade biomaterials allow an easy transfer from the lab to the industrial scale. This book reports ten different works, and a review, aiming to cover multiple strategies and pharmaceutical applications in the field of self-organizing nanovectors for drug delivery.

Targeting Cellular Signalling Pathways in Lung Diseases

Targeting Cellular Signalling Pathways in Lung Diseases
Author: Kamal Dua
Publsiher: Springer Nature
Total Pages: 135
Release: 2021
ISBN 10: 9813368276
ISBN 13: 9789813368279
Language: EN, FR, DE, ES & NL

Targeting Cellular Signalling Pathways in Lung Diseases Book Review:

COPD

COPD
Author: Cormac McCarthy
Publsiher: BoD – Books on Demand
Total Pages: 162
Release: 2018-02-21
ISBN 10: 9535137824
ISBN 13: 9789535137825
Language: EN, FR, DE, ES & NL

COPD Book Review:

Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide and is estimated to become the third most common cause of death over the next decade. The knowledge of COPD pathogenesis and the disease course has greatly improved this progression in understanding and continues to have significant implications in the management of this condition. Novel areas of interest in COPD pathogenesis include further development of animal models, a better understanding of the genetics and epigenetics, the role of the microbiome, and an increasing appreciation of the associated comorbidities. This book intends to provide the reader with a brief overview of these topics and also provide an in-depth review of the current nonpharmacological clinical approaches to managing patients with COPD.

Basic Epithelial Ion Transport Principles and Function

Basic Epithelial Ion Transport Principles and Function
Author: Kirk L. Hamilton,Daniel C. Devor
Publsiher: Springer Nature
Total Pages: 563
Release: 2020-11-26
ISBN 10: 3030527808
ISBN 13: 9783030527808
Language: EN, FR, DE, ES & NL

Basic Epithelial Ion Transport Principles and Function Book Review:

This book discusses unique ion channels and transporters that are located within epithelial tissues of various organs including the kidney, intestine, pancreas and respiratory tract. As the authors show, these channels and transporters play crucial roles in transepithelial ion and fluid transport across epithelia and their contribution to maintaining homeostasis. Readers will be introduced to the fundamentals of ion transport in terms of function, modelling, regulation, structure and pharmacology. This is the first of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. This volume focuses on basic fundamentals of epithelial transport physiology. There is a range of chapters dedicated to specific aspects of epithelial ion transport and cell function. Accordingly, the authors discuss techniques used to determine epithelial function, principles of epithelia transport, polarization of epithelial cells, mathematical modelling of epithelial ion transport, protein folding of ion channels, degradation epithelial ion channels, fundamentals of epithelial sodium, potassium and chloride transport, fundamentals of bicarbonate secretion, volume regulation, and microRNA regulation of epithelial channels and transporters. Given its scope, Volume 1 offers a valuable resource for physiology students, scientists and clinicians alike.

Asthma and COPD

Asthma and COPD
Author: Peter J. Barnes,Jeffrey M. Drazen,Stephen I. Rennard,Neil C. Thomson
Publsiher: Elsevier
Total Pages: 896
Release: 2009-03-19
ISBN 10: 0080920608
ISBN 13: 9780080920603
Language: EN, FR, DE, ES & NL

Asthma and COPD Book Review:

The Second Edition of Asthma and COPD: Basic Mechanisms and Clinical Management continues to provide a unique and authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it continues to be a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments. * Each chapter considers Asthma and COPD in side-by-side contrast and comparison – not in isolation - in the context of mechanism, triggers, assessments, therapies, and clinical management * Presents the latest and most comprehensive understandings of the mechanisms of inflammation in both Asthma and COPD * Most extensive reference to primary literature on both Asthma and COPD in one source. * Easy-to-read summaries of the latest advances alongside clear illustrations

The Pulmonary Neuroepithelial Body Microenvironment

The Pulmonary Neuroepithelial Body Microenvironment
Author: Inge Brouns,Line Verckist,Isabel Pintelon,Jean-Pierre Timmermans,Dirk Adriaensen
Publsiher: Springer Nature
Total Pages: 99
Release: 2021-05-05
ISBN 10: 3030658171
ISBN 13: 9783030658175
Language: EN, FR, DE, ES & NL

The Pulmonary Neuroepithelial Body Microenvironment Book Review:

This monograph sheds new light on pulmonary sensory receptors. Diving into the pulmonary microenvironment, the book focuses on the role of pulmonary neuroepithelial bodies (NEBs) as potential receptors and effectors, able to store and release neurotransmitters. It explores NEBs as potential stem cell niche and highlights the multidisciplinary approach taken to identify and study NEBs, including functional morphological investigation, live cell imaging, genetic models, and laser microdissection combined with gene expression analysis. Complexly organized NEBs are an integral part of the intrapulmonary airway epithelium of all air-breathing vertebrates. For decades a quest has been going on to unravel the functional significance of these intriguing structures that appear to be modified in the course of many pulmonary diseases. The NEB microenvironment (ME) is composed of organoid clusters of pulmonary neuroendocrine cells (PNECs) that are able to store and release neurotransmitters and are closely contacted by extensive nerve terminals, emphasizing a potential receptor/effector role and probable signalling to the central nervous system. PNECs are largely shielded from the airway lumen by a special type of Clara cells, the Clara-like cells, with potential stem cell characteristics. So far, functional studies of the pulmonary NEB ME revealed that PNECs can be activated by various mechanical and chemical stimuli, resulting in a calcium-mediated release of neurotransmitters. In the past decades, a number of publications have exposed NEBs as potential hypoxia sensors. Recent experimental evidence unveiled that the NEB ME is a quiescent stem cell niche in healthy postnatal lungs, and silencing may involve bone morphogenetic protein signalling mediated by vagal afferents. Only an integrated approach that takes all current information into account will be able to explain the full role of the pulmonary NEB ME in health and disease. This highly informative and carefully presented book, provides insights for researchers, PhD students with an interest in (bio)medical and veterinary science, especially in the field of the autonomic innervation of the lung, chemo-and mechanoreceptors

Stem Cell Based Therapy for Lung Disease

Stem Cell Based Therapy for Lung Disease
Author: Janette K. Burgess,Irene H. Heijink
Publsiher: Springer Nature
Total Pages: 259
Release: 2019-11-23
ISBN 10: 303029403X
ISBN 13: 9783030294038
Language: EN, FR, DE, ES & NL

Stem Cell Based Therapy for Lung Disease Book Review:

This book presents state-of-the-art pre-clinical models and clinical applications of stem-cell-based therapies applied to different lung diseases, with a special focus on the translation of bench data into clinical studies. Starting with the assumption that abnormal lung tissue repair and regeneration has emerged as the driving force underlying pathogenesis and progression in many lung diseases, it sheds new light on the potential of stem/stromal cells as drivers of repair and sources of reparative factors in the lung. The first part of the book offers an overview of stem cell types and mechanisms involved in lung development, homeostasis, repair and regeneration, and reveals the crucial role of the extracellular matrix within the lung microenvironment. In the second part, leading experts present the latest pre-clinical evidence and clinical applications of stem-cell-based therapies in a wide variety of lung diseases, ranging from COPD and lung fibrosis to other rare lung diseases. The last section discusses stem cell delivery systems and devices, such as aerosolised spray application. This book appeals to pneumologists, stem cell and matrix biologists, as well as bioengeneers with a special interest in regenerative medicine applied to pulmonary diseases.

Oncogenesis Inflammatory and Parasitic Tropical Diseases of the Lung

Oncogenesis  Inflammatory and Parasitic Tropical Diseases of the Lung
Author: Jean-Marie Kayembe
Publsiher: BoD – Books on Demand
Total Pages: 168
Release: 2013-02-13
ISBN 10: 9535109820
ISBN 13: 9789535109822
Language: EN, FR, DE, ES & NL

Oncogenesis Inflammatory and Parasitic Tropical Diseases of the Lung Book Review:

In this book dealing with the lung health, the authors focus on various fields, spreading from pulmonary oncogenesis, to inflammatory and parasitic lung diseases. The first section deals with the fundamental research on lung cancer that is mandatory for the development of novel and early biomarkers for diagnosis of the lung cancer. This development could be enhanced using experimental models despite the species barrier. Mouse models can help us understand the sequence of events involved in human lung neoplasia and their underlying molecular mechanisms. The results of the research could be used to identify novel targets for the development of new biological therapies. In the second section of this book, the role of inflammation in various respiratory diseases is outlined. The authors recall cellular mechanisms including neutrophils to improve the understanding of the phenomenon and help develop targeted therapies. The third section on parasitic tropical lung disease highlights the growing importance of neglected tropical diseases due to increased traffic across the continents and migration of the population. Physicians need to be aware of the symptoms and imaging findings of these diseases mainly in travelers and immigrants from tropical endemic areas.

Stem Cells and Regenerative Medicine

Stem Cells and Regenerative Medicine
Author: Walter C. Low,Catherine M. Verfaillie
Publsiher: World Scientific
Total Pages: 551
Release: 2008
ISBN 10: 9812775773
ISBN 13: 9789812775771
Language: EN, FR, DE, ES & NL

Stem Cells and Regenerative Medicine Book Review:

The commercialization of biotechnology has resulted in an intensive search for new biological resources for the purposes of increasing food productivity, medicinal applications, energy production, and various other applications. Although biotechnology has produced many benefits for humanity, the exploitation of the planet's natural resources has also resulted in some undesirable consequences such as diminished species biodiversity, climate change, environmental contamination, and intellectual property right and patent concerns.This book discusses the role of biological, ecological, environmental, ethical, and economic issues in the interaction between biotechnology and biodiversity, using different contexts. No other book has discussed all of these issues in a comprehensive manner. Of special interest is their impact when biotechnology is shared between developed and developing countries, and the lack of recognition of the rights of indigenous populations and traditional farmers in developing countries by large multinational corporations.

Interstitial Lung Disease

Interstitial Lung Disease
Author: Marvin I. Schwarz,Talmadge E. King
Publsiher: PMPH-USA
Total Pages: 941
Release: 2003
ISBN 10: 1550091794
ISBN 13: 9781550091793
Language: EN, FR, DE, ES & NL

Interstitial Lung Disease Book Review:

Interstitial Lung Disease, Fourth Edition is a complete publication of interstitial lung diseases and includes clinical, pathologic, radiologic, and physiologic evaluation of the patient with ILD. It provides a basic pathobiology and a complete description of individual disease entities. The book covers a wide array of disorders - sarcoidosis, asbestosis, hypersensitivity pneumonitis, drug-induced lung disease, connective tissue disease, and pulmonary vasculitis, to name but a few. This new edition also features an examination of future potential therapies for interstitial lung disease. Interstitial Lung Disease is divided into three sections. The Clinical Approach section provides the basis for recognizing the key features that allow a specific diagnosis to be achieved. The section dedicated to Basic Mechanisms emphasizes the many advances in genetics and cellular and molecular biology that have greatly expanded our understanding of the biological processes involved in the pathogenesis of the interstitial lung diseases. The third section titled Clinical Entities describes the clinical manifestations, radiologic patterns, histopathological features, and management of the specific p

Molecular Pathology of Lung Diseases

Molecular Pathology of Lung Diseases
Author: Dani S. Zander,Helmut Popper,Jaishree Jagirdar,Abida Haque,Roberto Barrios
Publsiher: Springer Science & Business Media
Total Pages: 682
Release: 2010-05-26
ISBN 10: 0387724303
ISBN 13: 9780387724300
Language: EN, FR, DE, ES & NL

Molecular Pathology of Lung Diseases Book Review:

This major work, complete with 150 illustrations, many of them in color, bridges the gap between clinical pulmonary pathology and basic molecular science. Through a highly visual approach that features an abundance of tables and diagrams, the book offers a practical disease-based overview. The first two sections of the volume provide the reader with general concepts, terminology and procedures in molecular pathology. The remainder of the volume is subdivided into neoplastic and non-neoplastic lung diseases with detailed chapters covering the current molecular pathology of specific diseases. The book will be essential reading for pathologists, pulmonologists, thoracic surgeons and other health care providers interested in lung disease.

Respiratory Disease and Infection

Respiratory Disease and Infection
Author: Mayank Vats
Publsiher: BoD – Books on Demand
Total Pages: 262
Release: 2013-02-06
ISBN 10: 9535109685
ISBN 13: 9789535109686
Language: EN, FR, DE, ES & NL

Respiratory Disease and Infection Book Review:

Medicine is an ever-changing science. Every day we are encountered with the new developments and knowledge in the pathogenesis, mechanism of disease, newer diagnostic modalities, treatment options and new challenges in the management of the various diseases. The same holds true for respiratory diseases with the emergence of new respiratory pathogens having significant impact on the respiratory system. Respiratory Diseases are an important contributor to the morbidity and mortality of mankind since antiquity and its prevalence is on rise in with new disease are being recognized, however little importance has been given to the respiratory disease due to low level of awareness in physicians and general public. This book has been designed to deliver the detailed knowledge about the various respiratory infections including viral, bacterial, and helminthic infections.