Low Abundance Proteome Discovery

Low Abundance Proteome Discovery
Author: Egisto Boschetti,Pier Giorgio Righetti
Publsiher: Newnes
Total Pages: 364
Release: 2013-03-26
ISBN 10: 0124045960
ISBN 13: 9780124045965
Language: EN, FR, DE, ES & NL

Low Abundance Proteome Discovery Book Review:

Low-Abundance Proteome Discovery addresses the most critical challenge in biomarker discovery and progress: the identification of low-abundance proteins. The book describes an original strategy developed by the authors that permits the detection of protein species typically found in very low abundance and that may yield valuable clues to future discoveries. Known as combinatorial peptide ligand libraries, these new methodologies are one of the hottest topics related to the study of proteomics and have applications in medical diagnostics, food quality, and plant analysis. The book is written for university and industry scientists starting proteomic studies of complex matrices (e.g., biological fluids, biopsies, recalcitrant plant tissues, foodstuff, and beverage analysis), researchers doing wet chemistry, and graduate-level students in the areas of analytical and biochemistry, biology, and genetics. Covers methodologies for enhancing the visibility of low-abundance proteins which, until now, has been the biggest challenge in biomarker progress Includes detailed protocols that address real-life needs in laboratory practice Addresses all applications, including human disease, food and beverage safety, and the discovery of new proteins/peptides of importance in nutraceutics Compiles the research and analytic protocols of the two scientists who are credited with the discovery of these landmark methodologies, also known as combinatorial peptide ligand libraries, for the identification of low-abundance proteins

Proteomic and Metabolomic Approaches to Biomarker Discovery

Proteomic and Metabolomic Approaches to Biomarker Discovery
Author: Haleem J. Issaq,Timothy D. Veenstra
Publsiher: Academic Press
Total Pages: 504
Release: 2019-10-24
ISBN 10: 0128197889
ISBN 13: 9780128197882
Language: EN, FR, DE, ES & NL

Proteomic and Metabolomic Approaches to Biomarker Discovery Book Review:

Proteomic and Metabolomic Approaches to Biomarker Discovery, Second Edition covers techniques from both proteomics and metabolomics and includes all steps involved in biomarker discovery, from study design to study execution. The book describes methods and presents a standard operating procedure for sample selection, preparation and storage, as well as data analysis and modeling. This new standard effectively eliminates the differing methodologies used in studies and creates a unified approach. Readers will learn the advantages and disadvantages of the various techniques discussed, as well as potential difficulties inherent to all steps in the biomarker discovery process. This second edition has been fully updated and revised to address recent advances in MS and NMR instrumentation, high-field NMR, proteomics and metabolomics for biomarker validation, clinical assays of biomarkers and clinical MS and NMR, identifying microRNAs and autoantibodies as biomarkers, MRM-MS assay development, top-down MS, glycosylation-based serum biomarkers, cell surface proteins in biomarker discovery, lipodomics for cancer biomarker discovery, and strategies to design studies to identify predictive biomarkers in cancer research. Addresses the full range of proteomic and metabolomic methods and technologies used for biomarker discovery and validation Covers all steps involved in biomarker discovery, from study design to study execution Serves as a vital resource for biochemists, biologists, analytical chemists, bioanalytical chemists, clinical and medical technicians, researchers in pharmaceuticals and graduate students

Proteomic and Metabolomic Approaches to Biomarker Discovery

Proteomic and Metabolomic Approaches to Biomarker Discovery
Author: Haleem J. Issaq,Timothy D. Veenstra
Publsiher: Academic Press
Total Pages: 504
Release: 2019-10-24
ISBN 10: 0128197889
ISBN 13: 9780128197882
Language: EN, FR, DE, ES & NL

Proteomic and Metabolomic Approaches to Biomarker Discovery Book Review:

Proteomic and Metabolomic Approaches to Biomarker Discovery, Second Edition covers techniques from both proteomics and metabolomics and includes all steps involved in biomarker discovery, from study design to study execution. The book describes methods and presents a standard operating procedure for sample selection, preparation and storage, as well as data analysis and modeling. This new standard effectively eliminates the differing methodologies used in studies and creates a unified approach. Readers will learn the advantages and disadvantages of the various techniques discussed, as well as potential difficulties inherent to all steps in the biomarker discovery process. This second edition has been fully updated and revised to address recent advances in MS and NMR instrumentation, high-field NMR, proteomics and metabolomics for biomarker validation, clinical assays of biomarkers and clinical MS and NMR, identifying microRNAs and autoantibodies as biomarkers, MRM-MS assay development, top-down MS, glycosylation-based serum biomarkers, cell surface proteins in biomarker discovery, lipodomics for cancer biomarker discovery, and strategies to design studies to identify predictive biomarkers in cancer research. Addresses the full range of proteomic and metabolomic methods and technologies used for biomarker discovery and validation Covers all steps involved in biomarker discovery, from study design to study execution Serves as a vital resource for biochemists, biologists, analytical chemists, bioanalytical chemists, clinical and medical technicians, researchers in pharmaceuticals and graduate students

Skeletal Biology and Medicine

Skeletal Biology and Medicine
Author: Mone Zaidi
Publsiher: Wiley-Blackwell
Total Pages: 352
Release: 2010-05-03
ISBN 10:
ISBN 13: STANFORD:36105133215082
Language: EN, FR, DE, ES & NL

Skeletal Biology and Medicine Book Review:

As part of the Annals of the New York Academy of Sciences series, this volume examines mechanisms involved in bone development and restructuring, including cellular and mechanical triggers, receptors, and signalling pathways. This volume also examines other factors associated with bone and musculoskeletal health, including physiological systems and disease states such as the immune system, inflammation, diabetes, infection and cancer. This book is ideal for Graduate students, medical students, researchers and clinicians in with an interest in anatomy, physiology, developmental biology, immunology, and musculoskeletal health NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.

Neuroproteomics

Neuroproteomics
Author: Andrew K. Ottens,Kevin K.W. Wang
Publsiher: Humana
Total Pages: 321
Release: 2009-08-05
ISBN 10:
ISBN 13: UOM:39015075683261
Language: EN, FR, DE, ES & NL

Neuroproteomics Book Review:

With the development of polypeptide ionization processes for mass spectrometry and the rapid processing of large-scale datasets with bioinformatics, researchers now have the tools necessary to propel neuroproteomics research to new levels. In Neuroproteomics: Methods and Protocols, experts in the neurological and analytical sciences present experimental details for applying proteomics to the study of the central nervous system (CNS) and its dysfunction through trauma and disease. Divided into four convenient sections, this collection covers CNS animal models used for neuroproteomics research, methods for separating and analyzing discrete subcomponents of the neuroproteome, large-scale approaches for CNS proteome characterization and quantification, as well as methods that evaluate biofluids and translate neuroproteomic results into clinical platforms. As a volume in the highly successful Methods in Molecular BiologyTM series, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Neuroproteomics: Methods and Protocols includes the clear "how-to" information needed to critically assess what can be accomplished in the field and how to best perform and evaluate neuroproteomic experiments in one’s own research.

Immobilized PH Gradients

Immobilized PH Gradients
Author: P. G. Righetti
Publsiher: Elsevier
Total Pages: 397
Release: 1990
ISBN 10: 0444813012
ISBN 13: 9780444813015
Language: EN, FR, DE, ES & NL

Immobilized PH Gradients Book Review:

Immobilized pH gradients (IPG) represent the most advanced development of isoelectric focusing (IEF). Originally developed to overcome all the problems of IEF in soluble amphoteric buffers (CA) (such as pH gradient instability, complexation with CA chemicals, unreproducibility of pH gradients, protein precipitation at the pI), it turned out to be an entirely new technique, quite different in principle and operation from conventional IEF. The book is thus meant to bring the reader up to date with this fast developing field. The book is divided into six chapters containing information on: detailed treatment of all the chemistry of the Immobiline chemicals; theory of pH gradient generation (computer simulations, tables with all the possible pH recipes); all analytical aspects of IPGs, including staining techniques, blotting etc.; two-dimensional maps, with a detailed treatise of advantages and limitations; preparative aspects of IPGs, including comparison with other preparative electrophoretic techniques; some examples of applications, including genetic and forensic analysis, blood polymorphism etc. The book is extensive and up-to-date, while also extensively covering the theory.

Plant Proteomics

Plant Proteomics
Author: Jesus V. Jorrin-Novo,Setsuko Komatsu,Wolfram Weckwerth,Stefanie Wienkoop
Publsiher: Humana Press
Total Pages: 786
Release: 2016-09-17
ISBN 10: 9781493960293
ISBN 13: 1493960296
Language: EN, FR, DE, ES & NL

Plant Proteomics Book Review:

Plant Proteomics: Methods and Protocols, Second Edition presents recent advances made in the field of proteomics and their application to plant biology and translational research. In recent years, improvements in techniques and protocols for high-throughput proteomics have been made at all workflow stages, from wet (sampling, tissue and cell fractionation, protein extraction, depletion, purification, separation, MS analysis, quantification) to dry lab (experimental design, algorithms for protein identification, bioinformatics tools for data analysis, databases, and repositories). Divided into nine convenient sections, chapters cover topics such as applications of gel-free, label- or label-free, imaging and targeted approaches to experimental model systems, crops and orphan species, as well as the study and analysis of PTMs, protein interactions, and specific families of proteins, and finally proteomics in translational research. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Plant Proteomics: Methods and Protocols, Second Edition seeks to serve both professionals and novices looking to exploit the full potential of proteomics in plant biology research.

American Biotechnology Laboratory

American Biotechnology Laboratory
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 2008
ISBN 10:
ISBN 13: STANFORD:36105123660420
Language: EN, FR, DE, ES & NL

American Biotechnology Laboratory Book Review:

Proteome Informatics

Proteome Informatics
Author: Conrad Bessant
Publsiher: Royal Society of Chemistry
Total Pages: 412
Release: 2016-11-15
ISBN 10: 1782626735
ISBN 13: 9781782626732
Language: EN, FR, DE, ES & NL

Proteome Informatics Book Review:

The field of proteomics has developed rapidly over the past decade nurturing the need for a detailed introduction to the various informatics topics that underpin the main liquid chromatography tandem mass spectrometry (LC-MS/MS) protocols used for protein identification and quantitation. Proteins are a key component of any biological system, and monitoring proteins using LC-MS/MS proteomics is becoming commonplace in a wide range of biological research areas. However, many researchers treat proteomics software tools as a black box, drawing conclusions from the output of such tools without considering the nuances and limitations of the algorithms on which such software is based. This book seeks to address this situation by bringing together world experts to provide clear explanations of the key algorithms, workflows and analysis frameworks, so that users of proteomics data can be confident that they are using appropriate tools in suitable ways.

Neuroscience Biomarkers and Biosignatures

Neuroscience Biomarkers and Biosignatures
Author: Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publsiher: National Academies Press
Total Pages: 128
Release: 2008-01-08
ISBN 10: 9780309178280
ISBN 13: 0309178282
Language: EN, FR, DE, ES & NL

Neuroscience Biomarkers and Biosignatures Book Review:

Biomarkers, or biological markers, are quantitative measurements that offer researchers and clinicians valuable insight into diagnosis, treatment and prognosis for many disorders and diseases. A major goal in neuroscience medical research is establishing biomarkers for disorders of the nervous system. Given the promising potential and necessity for neuroscience biomarkers, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened a public workshop and released the workshop summary entitled Neuroscience Biomarkers and Biosignatures: Converging Technologies, Emerging Partnerships. The workshop brought together experts from multiple areas to discuss the most promising and practical arenas in neuroscience in which biomarkers will have the greatest impact. The main objective of the workshop was to identify and discuss biomarker targets that are not currently being aggressively pursued but that could have the greatest near-term impact on the rate at which new treatments are brought forward for psychiatric and neurological disorders.

Archives of Pathology Laboratory Medicine

Archives of Pathology   Laboratory Medicine
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 2008
ISBN 10:
ISBN 13: NWU:35558005698572
Language: EN, FR, DE, ES & NL

Archives of Pathology Laboratory Medicine Book Review:

Radiation Proteomics

Radiation Proteomics
Author: Dariusz Leszczynski
Publsiher: Springer Science & Business Media
Total Pages: 130
Release: 2013-02-03
ISBN 10: 9400758960
ISBN 13: 9789400758964
Language: EN, FR, DE, ES & NL

Radiation Proteomics Book Review:

Methods of proteomics have been shown to be powerful tools in search of target proteins – proteins that respond in cells to an internal or an external stimulus. Proteomics is widely used in biomedical research. However, in radiation biology research, following exposures of living matter to low doses of either ionizing or non-ionizing radiation, proteomics approach is only very slowly gaining support. This book, by presenting the current status of the use of proteomics in radiation biology, will help to attract attention to the field of radiation proteomics.

Genetic Engineering Biotechnology News

Genetic Engineering   Biotechnology News
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 2009
ISBN 10:
ISBN 13: PSU:000059773535
Language: EN, FR, DE, ES & NL

Genetic Engineering Biotechnology News Book Review:

Recent Advances in Proteomics Research

Recent Advances in Proteomics Research
Author: Sameh Magdeldin
Publsiher: BoD – Books on Demand
Total Pages: 166
Release: 2015-11-11
ISBN 10: 9535122010
ISBN 13: 9789535122012
Language: EN, FR, DE, ES & NL

Recent Advances in Proteomics Research Book Review:

Proteomics refers to the entire complement of proteins, including modification. This promising discipline has enabled us to study proteins from a massive and comprehensive point of view. The book Recent Advances in Proteomics Research describes in five sections some of the applications of proteomics. This fine research has been written by leading experts worldwide. This book is aimed mainly at those interested in proteins and in the field of proteins, particularly biochemists, biologists, pharmacists, advanced graduate students and postgraduate researchers.

Plant Proteomics

Plant Proteomics
Author: Ganesh K. Agrawal,Randeep Rakwal
Publsiher: John Wiley & Sons
Total Pages: 808
Release: 2008-10-03
ISBN 10: 0470369833
ISBN 13: 9780470369838
Language: EN, FR, DE, ES & NL

Plant Proteomics Book Review:

Confidently face the challenges of proteomics research specific to plant science with the information in Plant Proteomics, which will introduce you to the techniques and methodologies required for the study of representative plant species. Read about proteomics studies in Arabidopsis, rice, and legumes and find information about common technologies like mass spectrometry and gel electrophoresis. Discover expression proteomics, functional proteomics, structural proteomics, bioinformatics, and systems biology, understand how to conduct proteomics studies in developing countries and underfunded laboratories, and gain access to guidelines for sample preparation.

Methods and Techniques in Drug Discovery

Methods and Techniques in Drug Discovery
Author: John Sterling,Ellyn J. T. D. Kerr,Shannon Simons
Publsiher: Unknown
Total Pages: 266
Release: 2005
ISBN 10:
ISBN 13: STANFORD:36105114585073
Language: EN, FR, DE, ES & NL

Methods and Techniques in Drug Discovery Book Review:

Serum Plasma Proteomics

Serum Plasma Proteomics
Author: Richard J Simpson,David W Greening
Publsiher: Humana Press
Total Pages: 412
Release: 2016-05-01
ISBN 10: 9781493958016
ISBN 13: 1493958011
Language: EN, FR, DE, ES & NL

Serum Plasma Proteomics Book Review:

Blood science has become a cornerstone of multiple disciplines. This book, contributed to by leading experts in the field, provides a comprehensive resource of protocols for areas, pre-analytical through to analytical, of plasma and serum proteomics.

Applied Genomics and Proteomics

Applied Genomics and Proteomics
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 2003
ISBN 10:
ISBN 13: CORNELL:31924099661708
Language: EN, FR, DE, ES & NL

Applied Genomics and Proteomics Book Review:

Principles of Proteomics

Principles of Proteomics
Author: Richard Twyman
Publsiher: Garland Science
Total Pages: 266
Release: 2004-05-01
ISBN 10: 0203507398
ISBN 13: 9780203507391
Language: EN, FR, DE, ES & NL

Principles of Proteomics Book Review:

Principles of Proteomics is designed specifically to explain the different stages of proteomic analysis, their complexities and their jargon to students and researchers in a non-technical overview of the field. The author describes the broad range of problems which proteomics can address, including structural proteomics, interaction proteomics, protein modification analysis and functional proteomics. Methodologies are described in user-friendly language, from the more traditional two-dimensional gel electrophoresis to the new developments in protein chip technologies. These are well presented in the context of overall strategies which can be adopted to address the different aspects of large-scale protein analysis.

Protein Purification

Protein Purification
Author: Jan-Christer Janson,Lars Rydén,Lars Ryden
Publsiher: John Wiley & Sons
Total Pages: 695
Release: 1998
ISBN 10: 9780471186267
ISBN 13: 0471186260
Language: EN, FR, DE, ES & NL

Protein Purification Book Review:

This is a state-of-the-art sourcebook on modern high-resolution biochemical separation techniques for proteins. It contains all the basic theory and principles used in protein chromatography and electrophoresis.