Kidney Biomarkers

Kidney Biomarkers
Author: Seema S. Ahuja,Brian Castillo
Publsiher: Academic Press
Total Pages: 342
Release: 2020-07-16
ISBN 10: 0128163747
ISBN 13: 9780128163740
Language: EN, FR, DE, ES & NL

Kidney Biomarkers Book Review:

Since laboratory testing and biomarkers are an integral part in the diagnosis and treatment of kidney disease, Kidney Biomarkers: Clinical Aspects and Laboratory Determination covers currently used biomarkers as well as markers that are in development. Laboratories are increasingly more involved in the follow-up confirmatory laboratory testing and this unique volume showcases the collaboration needed to solve diagnostic clinical puzzles between the laboratory and clinician. This volume provides guidance on laboratory test selection and results interpretation in patients. Sources of inaccurate results in the measurement of kidney biomarkers are discussed along with possibility of eliminating such interferences. Each chapter is organized with a uniform easy-to-follow format with insightful case examples highlighting the collaboration between clinical laboratorians and clinicians. Categorizes biomarkers into diagnostic markers, disease follow-up markers, and prognostic biomarkers Include case examples to show the collaboration between the clinical laboratorian and clinician Discusses the application of kidney biomarkers in clinical practice along with addressing laboratory aspects of kidney biomarker determination

Biomarkers of Kidney Disease

Biomarkers of Kidney Disease
Author: Charles L. Edelstein
Publsiher: Academic Press
Total Pages: 632
Release: 2016-11-08
ISBN 10: 0128030356
ISBN 13: 9780128030356
Language: EN, FR, DE, ES & NL

Biomarkers of Kidney Disease Book Review:

Biomarkers of Kidney Disease, Second Edition, focuses on the basic and clinical research of biomarkers in common kidney diseases, detailing the characteristics of an ideal biomarker. The latest techniques for biomarker detection, including metabolomics and proteomics are covered in the book. This comprehensive book details the latest advances made in the field of biomarker research and development in kidney diseases. The book is an ideal companion for those interested in biomarker research and development, proteomics and metabolomics, kidney diseases, statistical analysis, transplantation, and preeclampsia. New chapters include biomarkers of cardiovascular disease in patients with CKD, biomarkers of Polycystic Kidney Disease, and biomarkers and the role of nanomedicine. Explores both the practical and conceptual steps performed in the discovery of biomarkers in kidney disease Presents a comprehensive account of newer biomarker discover strategies, such as metabolomics and proteomics, all illustrated by clear examples Offers clear translational presentations by the top basic and clinical researchers in each specific renal disease, including AKI, transplantation, cancer, CKD, PKD, diabetic nephropathy, preeclampsia, and glomerular disease

Kidney Biomarkers

Kidney Biomarkers
Author: Seema S. Ahuja,Brian Castillo
Publsiher: Academic Press
Total Pages: 344
Release: 2020-07-31
ISBN 10: 0128159235
ISBN 13: 9780128159231
Language: EN, FR, DE, ES & NL

Kidney Biomarkers Book Review:

Since laboratory testing and biomarkers are an integral part in the diagnosis and treatment of kidney disease, Kidney Biomarkers: Clinical Aspects and Laboratory Determination covers currently used biomarkers as well as markers that are in development. Laboratories are increasingly more involved in the follow-up confirmatory laboratory testing and this unique volume showcases the collaboration needed to solve diagnostic clinical puzzles between the laboratory and clinician. This volume provides guidance on laboratory test selection and results interpretation in patients. Sources of inaccurate results in the measurement of kidney biomarkers are discussed along with possibility of eliminating such interferences. Each chapter is organized with a uniform easy-to-follow format with insightful case examples highlighting the collaboration between clinical laboratorians and clinicians. Categorizes biomarkers into diagnostic markers, disease follow-up markers, and prognostic biomarkers Include case examples to show the collaboration between the clinical laboratorian and clinician Discusses the application of kidney biomarkers in clinical practice along with addressing laboratory aspects of kidney biomarker determination

Biomarkers of Kidney Disease

Biomarkers of Kidney Disease
Author: Charles L. Edelstein
Publsiher: Academic Press
Total Pages: 454
Release: 2010-10-27
ISBN 10: 9780123756732
ISBN 13: 0123756731
Language: EN, FR, DE, ES & NL

Biomarkers of Kidney Disease Book Review:

A biomarker is a molecule that is measured as a marker of normal biological processes, disease processes or the response to a diagnostic or therapeutic intervention. Kidney diseases like acute kidney injury, chronic kidney disease, diabetic nephropathy, glomerular disease, renal cancer and preeclampsia still have a high morbidity. Measurement of biomarkers in the blood or urine that detect patients at risk of kidney diseases or that detect kidney diseases in the earliest stage may ultimately result in preventative or earlier or more effective treatments for kidney diseases. Biomarkers of Kidney Disease reviews the basic and clinical research on biomarkers of the common kidney diseases including acute kidney injury, chronic kidney disease, renal cancer, diabetic nephropathy, glomerular disease and preeclampsia. The characteristics of an ideal biomarker of kidney diseases and statistical analysis of biomarker studies is detailed. The latest techniques for biomarker detection like metabolomics and proteomics is covered in the book. This comprehensive book details the latest advances made in the field of biomarker research and development in kidney diseases. The book is an ideal companion for those interested in biomarker research and development, proteomics and metabolomics, kidney diseases, statistical analysis, transplantation and preeclampsia. Presents a comprehensive, translational source for all aspects of renal biomarkers in one reference work Experts in renal disease biomarkers (from all areas of academic and medical research) take readers from the bench research (cellular and molecular mechanism) to new therapeutic approaches

Biomarkers in Renal Disease

Biomarkers in Renal Disease
Author: Mitchell H. Rosner
Publsiher: Nova Publishers
Total Pages: 151
Release: 2008
ISBN 10: 9781604561135
ISBN 13: 1604561130
Language: EN, FR, DE, ES & NL

Biomarkers in Renal Disease Book Review:

Advances in long-term improvement and outcomes of patients with kidney disease will require the use of novel biomarkers to identify patients at high risk for kidney disease and to diagnose kidney disease early for effective treatment. A biomarker is a substance found in the blood, body fluids or tissues that provides a measure of normal biological or pathological processes or response to pharmacological compounds or drugs. There are a wide variety of biomarkers including but not limited to mRNA, proteins and peptides, and lipid molecules. In AKI, important pathophysiological processes such as inflammation, apoptotic and necrotic cell death and, tubule regeneration may be reflected in blood or urine. An array of candidate markers along with clinical information in long-term clinical studies with appropriate analytical methodologies will likely provide prognostic information. Despite well-known limitations, currently the most widely used biomarkers for the early diagnosis of CKD and AKI are proteinuria, serum creatinine and blood urea nitrogen. Most clinicians are aware that serum creatinine and blood urea nitrogen are poor biomarkers due to inherent characteristics of these molecules and handling by the kidney. Creatinine is secreted and urea nitrogen is reabsorbed by the renal tubules. Many endogenous substances interfere in the assay for creatinine. Serum creatinine and urea appear late after acute kidney injury and the serum levels in part depend on the generation (large or small body mass). Acute kidney injury is a non steady state condition thus serum creatinine and urea nitrogen will lag behind kidney injury. For these reasons new biomarkers are imperative. With knowledge of these limitations in use of current biomarkers and the lack of progress in reducing the mortality and morbidity from kidney disease, there has been a great surge of interest in identifying novel biomarkers with a particular emphasis on the early diagnosis of kidney disease. A variety of methods have been employed including transcriptomics, proteomics, gene arrays and lipidomics. Currently, candidate biomarkers have been found in different disorders and have been tested in humans and many candidate biomarkers have yet to be identified. Most studies to date are preliminary and require validation in large multicentre studies followed by commercial assay development validation and testing. This new book outlines the rapid advances made in the field of biomarker development for kidney disease in which a variety of novel molecules have been identified and studied in humans.

Biomarkers in Kidney Disease

Biomarkers in Kidney Disease
Author: Vinood B. Patel
Publsiher: Springer
Total Pages: 1250
Release: 2016-03-11
ISBN 10: 9789400776982
ISBN 13: 9400776985
Language: EN, FR, DE, ES & NL

Biomarkers in Kidney Disease Book Review:

In the past decade there has been a major sea change in the way disease is diagnosed and investigated due to the advent of high throughput technologies, such as microarrays, lab on a chip, proteomics, genomics, lipomics, metabolomics etc. These advances have enabled the discovery of new and novel markers of disease relating to autoimmune disorders, cancers, endocrine diseases, genetic disorders, sensory damage, intestinal diseases etc. In many instances these developments have gone hand in hand with the discovery of biomarkers elucidated via traditional or conventional methods, such as histopathology or clinical biochemistry. Together with microprocessor-based data analysis, advanced statistics and bioinformatics these markers have been used to identify individuals with active disease or pathology as well as those who are refractory or have distinguishing pathologies. New analytical methods that have been used to identify markers of disease and is suggested that there may be as many as 40 different platforms. Unfortunately techniques and methods have not been readily transferable to other disease states and sometimes diagnosis still relies on single analytes rather than a cohort of markers. There is thus a demand for a comprehensive and focused evidenced-based text and scientific literature that addresses these issues. Hence the formulation of Biomarkers in Disease. The series covers a wide number of areas including for example, nutrition, cancer, endocrinology, cardiology, addictions, immunology, birth defects, genetics, and so on. The chapters are written by national or international experts and specialists.

Biomarkers of Renal Diseases

Biomarkers of Renal Diseases
Author: Joaquín García-Estañ,Felix Vargas
Publsiher: MDPI
Total Pages: 276
Release: 2021-01-19
ISBN 10: 3039439111
ISBN 13: 9783039439119
Language: EN, FR, DE, ES & NL

Biomarkers of Renal Diseases Book Review:

This book provides important and updated information on current research devoted to urinary biomarkers. Urinary biomarkers are characteristics that can be objectively measured and evaluated as indicators of normal biological or pathogenic processes of pharmacological responses to therapeutic intervention.

Urine Proteomics in Kidney Disease Biomarker Discovery

Urine Proteomics in Kidney Disease Biomarker Discovery
Author: Youhe Gao
Publsiher: Springer
Total Pages: 203
Release: 2014-10-29
ISBN 10: 9401795231
ISBN 13: 9789401795234
Language: EN, FR, DE, ES & NL

Urine Proteomics in Kidney Disease Biomarker Discovery Book Review:

This book systematically summarizes the ideas and technologies used in urine proteome analysis. It argues that change is the core of biomarker definition since the body uses its homeostatic mechanisms to correct changes in the blood. This means that urine is probably a better source of biomarkers than blood. A roadmap to the urinary biomarker era is proposed, and researchers are reminded of the potential opportunities and risks in their study design. Kidney diseases are emphasized as they produce the most significant changes in urine. This book tries to show researchers and graduate students, who are in or entering the field, "all things considered" rather than "the current affair".

ADQI Consensus on AKI Biomarkers and Cardiorenal Syndromes

ADQI Consensus on AKI Biomarkers and Cardiorenal Syndromes
Author: J.A. Kellum,P.A. McCullough,R.L. Mehta,P.T. Murray,C. Ronco
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 216
Release: 2013-05-14
ISBN 10: 3318024074
ISBN 13: 9783318024074
Language: EN, FR, DE, ES & NL

ADQI Consensus on AKI Biomarkers and Cardiorenal Syndromes Book Review:

Associated with both acute kidney injury (AKI) and cardio-renal syndromes (CRS), new biomarkers represent both a popular area of investigation and a new opportunity for advancement of therapy. This book contains the resolutions of the most recent ADQI conferences on biomarkers in AKI (Dublin) and on cardio-renal syndromes (Venice). The first part answers specific questions about new biomarkers and their use and utility in AKI: What are the most suitable candidate molecules and physiologic measures, how solid and evidence based is the discovery phase? How can we incorporate the new biomarkers in the AKI conceptual model describing the evolution from susceptibility to insult, decreased GFR and organ death? Even if we have a positive biomarker pattern and we can identify patients at risk or patients with early or even subclinical AKI, how is this information affecting our clinical behavior and practice? The second part is dedicated to the appraisal of the current knowledge about the pathophysiological mechanisms involved in different forms of CRS: it contains contributions on the state-of-the-art knowledge and practice of CRS, particularly focusing on the pathophysiology of the five subtypes. Acute and chronic mechanisms of damage are explored in depth, with particular attention to the primacy of organ involvement and the subsequent pathways of organ crosstalk.Presenting the most recent research in the field of biomarkers, AKI and CRS, this publication is an important educational tool for advanced investigators and clinical experts, but also for students and fellows.

Identification of Potential Protein Biomarkers of Low Level Kidney Degradation

Identification of Potential Protein Biomarkers of Low Level Kidney Degradation
Author: Christopher Lee Woolard
Publsiher: Unknown
Total Pages: 149
Release: 2009
ISBN 10: 1928374650XXX
ISBN 13: OCLC:1005738486
Language: EN, FR, DE, ES & NL

Identification of Potential Protein Biomarkers of Low Level Kidney Degradation Book Review:

The purpose of this research was the identification of potential dose-dependent and time-dependent serum protein biomarkers of low level kidney degradation in a rat model. Potential biomarkers were evaluated based on differential protein expression between control and dosed samples in rat serum. Proteins of interest demonstrated upregulation at a minimum 1.5 fold increase in protein concentration control versus dosed sample. In order to identify common biomarkers of kidney decrement, three nephrotoxins were chosen to target specific locations of the kidney: 1) D-Serine, which causes necrosis of the proximal straight tubules, 2) Puromycin, an antibiotic that degrades the Glomerular Basement Membrane (GBM), and 3) Bromoethyl Amine (BEA), which affects the proximal tubules as well. Rats were dosed with individual neprotoxins and serum collected at Pre-dose, 24 hrs Post dose, and at terminal sacrifice for Puromycin andBEA, and at 12 hrs and 24 hrs post-dose from d-serine. The collected serum sample was enriched to remove abundant proteins, separated using 2D Difference in Gel Electrophoresis (DIGE), and screened for potential up-regulated biomarkers based on difference in fluorescent intensity using computer software. Finally, the proteins were trypsin digested and the resultant peptides identified by MALDI-TOF/TOF mass spectroscopy. The study results indicated hornerin as a potential biomarker though no dose- or time-dependent toxicity could be determined.

Acute Kidney Injury

Acute Kidney Injury
Author: Claudio Ronco,Rinaldo Bellomo,John A. Kellum
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 463
Release: 2007-01-01
ISBN 10: 3805582714
ISBN 13: 9783805582711
Language: EN, FR, DE, ES & NL

Acute Kidney Injury Book Review:

Acute kidney injury is defined as an abrupt change in serum creatinine and/or urine output, and a majority of patients admitted to the ICU have some evidence of the disorder. Unfortunately, treatment for this complex syndrome is as yet lacking and understanding is limited. An interdisciplinary panel of experts has contributed to this volume, illuminating some of the fundamental and complex aspects of the disorder ranging from pathophysiology to treatment, from emerging biomarkers to genetic polymorphisms. Other contributions focus on immunological issues or the many complications of acute kidney injury and co-morbid conditions encountered, covering the fundamentals as well as the latest developments. Moreover, important technical aspects of extracorporeal therapies including vascular access, anticoagulation or fluid composition are introduced, and different approaches to renal support from intermittent dialysis to continuous therapies and hybrid techniques are discussed. A description of advanced extracorporeal techniques of organ support and their role in the management of sepsis and acute kidney injury in the context of an overall strategy of multi-organ failure management concludes the discussions. This volume not only provides a practical and up-to-date summary of current knowledge and technology, but also imparts a fundamental understanding of the pathogenesis and likely future developments in this field. It also serves to challenge and re-examine the fundamental underlying assumptions we hold regarding critical illness in general and acute kidney injury in particular.

Managing Renal Injury in the Elderly Patient

Managing Renal Injury in the Elderly Patient
Author: Michael Haase,Anja Haase-Fielitz
Publsiher: Springer Science & Business Media
Total Pages: 100
Release: 2013-10-31
ISBN 10: 3642399479
ISBN 13: 9783642399473
Language: EN, FR, DE, ES & NL

Managing Renal Injury in the Elderly Patient Book Review:

As the number of people aged 65 years and above rises, physicians are increasingly confronted by elderly patients with impaired renal function, altered drug metabolism and multiple comorbidities. This book examines in detail the nature of renal injury in the elderly and its optimal management. A wide range of key topics are covered, including end-stage renal disease, diabetic nephropathy, acute kidney injury, drug metabolism and renal toxicity, dialysis and its complications and the use of renal transplantation. In addition, the assessment of glomerular filtration rate in the elderly and the role of novel renal biomarkers are carefully examined. Quality of life issues, the significance of other age-related medical problems and end of life care are also discussed. This book will be of value not only to nephrologists but also to general practitioners, medical students, intensivists, cardiologists, pharmacologists and those working in related specialties.​

Biomarkers in Drug Development

Biomarkers in Drug Development
Author: Michael R. Bleavins,Claudio Carini,Mallé Jurima-Romet,Ramin Rahbari
Publsiher: John Wiley & Sons
Total Pages: 784
Release: 2011-09-20
ISBN 10: 1118210425
ISBN 13: 9781118210420
Language: EN, FR, DE, ES & NL

Biomarkers in Drug Development Book Review:

Discover how biomarkers can boost the success rate of drugdevelopment efforts As pharmaceutical companies struggle to improve the success rateand cost-effectiveness of the drug development process, biomarkershave emerged as a valuable tool. This book synthesizes and reviewsthe latest efforts to identify, develop, and integrate biomarkersas a key strategy in translational medicine and the drugdevelopment process. Filled with case studies, the bookdemonstrates how biomarkers can improve drug development timelines,lower costs, facilitate better compound selection, reducelate-stage attrition, and open the door to personalizedmedicine. Biomarkers in Drug Development is divided into eightparts: Part One offers an overview of biomarkers and their role in drugdevelopment. Part Two highlights important technologies to help researchersidentify new biomarkers. Part Three examines the characterization and validation processfor both drugs and diagnostics, and provides practical advice onappropriate statistical methods to ensure that biomarkers fulfilltheir intended purpose. Parts Four through Six examine the application of biomarkers indiscovery, preclinical safety assessment, clinical trials, andtranslational medicine. Part Seven focuses on lessons learned and the practical aspectsof implementing biomarkers in drug development programs. Part Eight explores future trends and issues, including dataintegration, personalized medicine, and ethical concerns. Each of the thirty-eight chapters was contributed by one or moreleading experts, including scientists from biotechnology andpharmaceutical firms, academia, and the U.S. Food and DrugAdministration. Their contributions offer pharmaceutical andclinical researchers the most up-to-date understanding of thestrategies used for and applications of biomarkers in drugdevelopment.

Chronic Kidney Disease Dialysis and Transplantation E Book

Chronic Kidney Disease  Dialysis  and Transplantation E Book
Author: Jonathan Himmelfarb,T. Alp Ikizler
Publsiher: Elsevier Health Sciences
Total Pages: 768
Release: 2018-11-06
ISBN 10: 0323531725
ISBN 13: 9780323531726
Language: EN, FR, DE, ES & NL

Chronic Kidney Disease Dialysis and Transplantation E Book Book Review:

Contains expanded content on economics and outcomes of treatment, as well as acute kidney injury. Covers hot topics such as the genetic causes of chronic kidney disease, ethical challenges and palliative care, and home hemodialysis. Discusses the latest advances in hypertensive kidney disease, vitamin D deficiency, diabetes management, transplantation, and more. Provides a clear visual understanding of complex information with high-quality line drawings, photographs, and diagnostic and treatment algorithms.

Biomarker

Biomarker
Author: Ghousia Begum
Publsiher: BoD – Books on Demand
Total Pages: 248
Release: 2018-09-05
ISBN 10: 1789236665
ISBN 13: 9781789236668
Language: EN, FR, DE, ES & NL

Biomarker Book Review:

This book investigates the emerging use of biomarkers as a diagnostic tool for the identification of patients with an abnormal condition or as a tool for staging the extent of disease, as an indicator of disease prognosis. Chapters in Part I focus on biomarkers for cancer, including breast cancer and pancreatic cancer, as well as circulating microRNA profiling in cancer biomarker discovery. Chapters in Part II focus on biomarkers of other diagnoses/diseases, including sepsis, childhood renal diseases, pulmonary diseases, Alzheimer's, leishmaniasis, and heart failure. This book investigates the emerging use of biomarkers as a diagnostic tool for the identification of patients with an abnormal condition or as a tool for staging the extent of disease, as an indicator of diseases prognosis. The book is of considerable importance for a broad range of people including researchers, clinicians, and university students.

The Path from Biomarker Discovery to Regulatory Qualification

The Path from Biomarker Discovery to Regulatory Qualification
Author: Federico Goodsaid,William B. Mattes
Publsiher: Academic Press
Total Pages: 206
Release: 2013-07-16
ISBN 10: 0123944082
ISBN 13: 9780123944085
Language: EN, FR, DE, ES & NL

The Path from Biomarker Discovery to Regulatory Qualification Book Review:

The Path from Biomarker Discovery to Regulatory Qualification is a unique guide that focuses on biomarker qualification, its history and current regulatory settings in both the US and abroad. This multi-contributed book provides a detailed look at the next step to developing biomarkers for clinical use and covers overall concepts, challenges, strategies and solutions based on the experiences of regulatory authorities and scientists. Members of the regulatory, pharmaceutical and biomarker development communities will benefit the most from using this book—it is a complete and practical guide to biomarker qualification, providing valuable insight to an ever-evolving and important area of regulatory science. For complimentary access to chapter 13, 'Classic' Biomarkers of Liver Injury, by John R. Senior, Associate Director for Science, Food and Drug Administration, Silver Spring, Maryland, USA, please visit the following site: http://tinyurl.com/ClassicBiomarkers Contains a collection of experiences of different groups taking different types of biomarkers to different levels of qualification and provides insightful case studies of an important area of regulatory science Focuses on practical advice, concepts, strategies and overall outcomes to support those working toward biomarker qualification for clinical use Offers a valuable resource for members of the regulatory, pharmaceutical and biomarker development communities.

Biomarkers of Common Childhood Renal Diseases

Biomarkers of Common Childhood Renal Diseases
Author: Samuel N. Uwaezuoke
Publsiher: Unknown
Total Pages: 135
Release: 2018
ISBN 10: 1928374650XXX
ISBN 13: OCLC:1154220783
Language: EN, FR, DE, ES & NL

Biomarkers of Common Childhood Renal Diseases Book Review:

Novel biomarkers are now used in the diagnostic and prognostic evaluation of common kidney diseases in children. The increased scientific interest in these biomarkers is partly due to the remarkable progress in their discovery techniques, and their validation in clinical subjects. However, the wide variation in their sensitivity and specificity is still a major concern. In the identification of biomarkers of kidney injury, an ideal biomarker should be produced after organ injury in concentrations which directly correlates with the degree of injury; should be easily measured in body fluids; and should serve as a potential tool to monitor therapeutic response which is predicated upon a post-injury decrease in its concentration. This book chapter aims to highlight and discuss the novel biomarkers used in the diagnostic and prognostic evaluation of common acute diseases of the kidney in children, such as urinary tract infection (UTI) and acute kidney injury (AKI), as well as chronic kidney disease (CKD) secondary to idiopathic nephrotic syndrome (INS) and diabetic nephropathy (DN).

Transfusion Medicine for Pathologists

Transfusion Medicine for Pathologists
Author: Brian Castillo,Amitava Dasgupta,Kimberly Klein,Hlaing Tint,Amer Wahed
Publsiher: Academic Press
Total Pages: 222
Release: 2018-06-29
ISBN 10: 0128143142
ISBN 13: 9780128143148
Language: EN, FR, DE, ES & NL

Transfusion Medicine for Pathologists Book Review:

Transfusion Medicine for Pathologists: A Comprehensive Review for Board Preparation, Certification, and Clinical Practice is a concise study guide designed to complement standard textbooks in the field of clinical pathology. Pathology residents and fellows of transfusion medicine will find this book useful as a preparation tool for their exams. In addition, the book is a valuable timesaver for busy residents looking for a focused and compact study guide on transfusion medicine that will also be ideal for practicing pathologists who cross-cover transfusion medicine in their clinical practice. Incorporates key words at the end of each chapter for quick review before an exam Includes concise and easy-to-digest chapters ranging from Donor Selection and Testing, to Blood Bank Testing, Transfusion Reactions, Apheresis, Hemotherapy, Special Transfusion Situations, and more Focuses on key topics to study for board examinations, saving time during busy residency programs

Biomarkers

Biomarkers
Author: Vishal S. Vaidya,Joseph V. Bonventre
Publsiher: John Wiley & Sons
Total Pages: 632
Release: 2010-10-28
ISBN 10: 9780470918555
ISBN 13: 0470918551
Language: EN, FR, DE, ES & NL

Biomarkers Book Review:

This book provides an introduction to the field of biomarkers, how they have been and can be used, and how different approaches can be used to identify, characterize, and monitor biomarkers. The book has chapters on topics including HIV, Cancer, Parkinson’s, vascular injury, environmental exposure. A following section discusses the technologies (diagnostics and assays) to detect biomarkers and authors have emphasized the preclinical and clinical manifestation of the injury/disease process.

Accelerating the Development of Biomarkers for Drug Safety

Accelerating the Development of Biomarkers for Drug Safety
Author: Institute of Medicine,Board on Health Sciences Policy,Forum on Drug Discovery, Development, and Translation
Publsiher: National Academies Press
Total Pages: 100
Release: 2009-07-20
ISBN 10: 9780309142311
ISBN 13: 0309142318
Language: EN, FR, DE, ES & NL

Accelerating the Development of Biomarkers for Drug Safety Book Review:

Biomarkers can be defined as indicators of any biologic state, and they are central to the future of medicine. As the cost of developing drugs has risen in recent years, reducing the number of new drugs approved for use, biomarker development may be a way to cut costs, enhance safety, and provide a more focused and rational pathway to drug development. On October 24, 2008, the IOM's Forum on Drug Discovery, Development, and Translation held "Assessing and Accelerating Development of Biomarkers for Drug Safety," a one-day workshop, summarized in this volume, on the value of biomarkers in helping to determine drug safety during development.