Ketamine for Treatment Resistant Depression

Ketamine for Treatment Resistant Depression
Author: Gustavo H. Vazquez,Carlos A. Zarate,Elisa Brietzke
Publsiher: Academic Press
Total Pages: 168
Release: 2020-10-01
ISBN 10: 0128210346
ISBN 13: 9780128210345
Language: EN, FR, DE, ES & NL

Ketamine for Treatment Resistant Depression Book Review:

Ketamine for Treatment-Resistant Depression: Neurobiology and Applications provides a simple, evidence-based overview for neuropsychiatrists and translational researchers on this medication, its mechanisms of actions, eligibility of patients for treatment, and the preparation and implementation of ketamine clinics. Provides efficacy research on ketamine as a treatment for depression Identifies best practices for clinical use, both long-term and acute Discusses the molecular mechanisms and neurobiology of action

Ketamine for Treatment Resistant Depression

Ketamine for Treatment Resistant Depression
Author: Sanjay J. Mathew,Carlos A. Zarate, Jr.
Publsiher: Springer
Total Pages: 155
Release: 2016-11-25
ISBN 10: 3319429256
ISBN 13: 9783319429250
Language: EN, FR, DE, ES & NL

Ketamine for Treatment Resistant Depression Book Review:

This book brings together an international group of clinicians and researchers from a broad swath of inter-related disciplines to offer the most up-to-date information about clinical and preclinical research into ketamine and second-generation “ketamine-like” fast-acting antidepressants. Currently available antidepressant medications act through monoaminergic systems, are ineffective for many individuals suffering from depression, and are associated with a delayed onset of peak efficacy of several months. The unexpected emergence of ketamine, an anesthetic N-methyl-D-aspartate (NMDA) receptor antagonist, as a rapid-acting antidepressant has reinvigorated CNS drug discovery research and catalyzed investigation in patient populations historically ignored in antidepressant drug development programs, particularly treatment-resistant patients and those with suicidality. Recent industry and academic research efforts have coalesced to explore NMDA receptor and glutamatergic molecular targets that lack ketamine’s psychotomimetic side effects and abuse liability but retain its rapid onset of efficacy. However, many fundamental questions remain regarding the neurobiological mechanisms underlying ketamine’s rapid antidepressant effects and the puzzling persistence of benefits observed in some patients following a single dose. This book examines how insights from these studies are forging new conceptual models of the neurobiology of stress-related affective, anxiety, and addictive disorders and the nature of treatment resistance. It also discusses how ketamine’s rapid antidepressant effects provide a scientific platform to facilitate innovation in clinical trial designs pertaining to patient selection, choice of control group, outcome measures, and dose-optimization. This book brings together data and insights from this rapidly expanding and extraordinarily promising field of study. Readers will be able to extract integrated themes and useful insights from the material contained in these diverse chapters and appreciate the paradigm-shifting contributions of ketamine to modern psychiatry and clinical neuroscience research.

Ketamine for Depression

Ketamine for Depression
Author: Dr. Stephen J. Hyde
Publsiher: Xlibris Corporation
Total Pages: 222
Release: 2015-09-04
ISBN 10: 1503509532
ISBN 13: 9781503509535
Language: EN, FR, DE, ES & NL

Ketamine for Depression Book Review:

Given the unacceptably high rates of suffering, disability and premature death experienced by people with treatment-resistant depression and the surprisingly low rates of problems arising from the use of ketamine to treat the disorder, this is a therapy that all patients and their doctors should be discussing. This book summarises the research that has been carried out into ketamine for the treatment of depression over the past 15 years and, most importantly, describes different ways of using ketamine that are both practical and cost–effective. Currently most ketamine therapy is given intravenously in specialised clinics at considerable expense, but the author has successfully treated patients with low-dose sublingual ketamine and his patients have been able to safely take this at home. Profits from the sales of this book will assist further research into the use of ketamine for the treatment of depression.

Treatment resistant Mood Disorders

Treatment resistant Mood Disorders
Author: Andre Carvalho,Roger McIntyre
Publsiher: Oxford University Press, USA
Total Pages: 160
Release: 2014-05-01
ISBN 10: 0198707991
ISBN 13: 9780198707998
Language: EN, FR, DE, ES & NL

Treatment resistant Mood Disorders Book Review:

Treatment-resistant major depression and bipolar disorder are highly prevalent and disabling conditions associated with substantial morbidity and mortality. The assessment and management of refractory patients with mood disorders is a major clinical challenge for mental health providers. Part of the Oxford Psychiatry Library (OPL) series, this pocketbook provides a concise view of the current definitions, assessment and evidence-based management of treatment-resistant mood disorders and reviews novel therapeutic targets for mood disorders, which may enhance the therapeutic armamentarium of clinicians in the near future. The pocketbook serves as a useful guide for mental health practitioners, including psychiatrists, clinical psychologists, trainees, and interested primary care physicians.

Rapid Acting Antidepressants

Rapid Acting Antidepressants
Author: Anonim
Publsiher: Academic Press
Total Pages: 402
Release: 2020-06-29
ISBN 10: 0128201908
ISBN 13: 9780128201909
Language: EN, FR, DE, ES & NL

Rapid Acting Antidepressants Book Review:

The Advances in Pharmacology series presents a variety of chapters from the best authors in the field. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series

Major Depressive Disorder

Major Depressive Disorder
Author: Roger S McIntyre
Publsiher: Elsevier Health Sciences
Total Pages: 202
Release: 2019-08-25
ISBN 10: 0323581323
ISBN 13: 9780323581325
Language: EN, FR, DE, ES & NL

Major Depressive Disorder Book Review:

Get a quick, expert overview of the key issues surrounding best practices and current consensus on major depressive disorder (MDD). This concise resource by Drs. Roger S. McIntyre, Carola Rong, Mehala Subramaniapillai, and Yena Lee consolidates today’s available information on this complex topic into one convenient resource, making it an ideal, easy-to-digest reference for both psychiatrists and primary care physicians. Covers genetics and epigenetics, brain structural abnormalities, cognition, neuroendocrine alterations, and inflammatory abnormalities as they relate to MDD. Contains chapters on psychiatric comorbidity, pharmacological treatments, neuromodulatory treatments, lifestyle interventions, internet-based/technology-based interventions, and glutamate alterations.

Ketamine

Ketamine
Author: Kenji Hashimoto,Soichiro Ide,Kazutaka Ikeda
Publsiher: Springer Nature
Total Pages: 189
Release: 2020-03-05
ISBN 10: 9811529027
ISBN 13: 9789811529023
Language: EN, FR, DE, ES & NL

Ketamine Book Review:

This book presents the latest data from basic research and clinical trials supporting the effectiveness of ketamine as a treatment for depression, bipolar disorder, and suicidal behavior, setting these positive findings within the context of the serious problem of ketamine abuse. The first part of the book focuses on the evidence regarding ketamine abuse, with specific reference to Asian countries, and discusses countermeasures and complication management. It then addresses the mechanisms underlying the antidepressant and side effects of ketamine, which have remained elusive, describing and discussing important new research findings. Further, it explains insights gained from whole brain imaging in rodents and from behavioral pharmacology, and presents evidence regarding the role of gut microbiota, the NMDA receptor GluN2D subunit, and the lateral habenula in the actions of ketamine. These advances form the basis for the safer use of ketamine in patients with treatment-resistant depression and are expected to lead to the development of new antidepressants.

Repeated Intranasal Ketamine for Treatment resistant Depression the Way to Go Results from a Pilot Randomised Controlled Trial

Repeated Intranasal Ketamine for Treatment resistant Depression     the Way to Go  Results from a Pilot Randomised Controlled Trial
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 2021
ISBN 10:
ISBN 13: OCLC:1051947420
Language: EN, FR, DE, ES & NL

Repeated Intranasal Ketamine for Treatment resistant Depression the Way to Go Results from a Pilot Randomised Controlled Trial Book Review:

Background: Ketamine research in depression has mostly used intravenous, weight-based approaches, which are difficult to translate clinically. Intranasal (IN) ketamine is a promising alternative but no controlled data has been published on the feasibility, safety and potential efficacy of repeated IN ketamine treatments. Methods: This randomised, double-blind, placebo-controlled pilot study compared a 4-week course of eight treatments of 100 mg ketamine or 4.5 mg midazolam. Each treatment was given as 10 separate IN sprays, self-administered 5 min apart. The study was stopped early due to poor tolerability after five treatment-resistant depressed participants were included. Feasibility, safety (acute and cumulative), cognitive and efficacy outcomes were assessed. Plasma ketamine and norketamine concentrations were assayed after the first treatment. Results: Significant acute cardiovascular, psychotomimetic and neurological side effects occurred at doses 100 mg ketamine. No participants were able to self-administer all 10 ketamine sprays due to incoordination; treatment time occasionally had to be extended (45 min) due to acute side effects. No hepatic, cognitive or urinary changes were observed after the treatment course in either group. There was an approximately two-fold variation in ketamine and norketamine plasma concentrations between ketamine participants. At course end, one participant had remitted in each of the ketamine and midazolam groups. Conclusions: IN ketamine, with the drug formulation and delivery device used, was not a useful treatment approach in this study. Absorption was variable between individuals and acute tolerability was poor, requiring prolonged treatment administration time in some individuals. The drug formulation, the delivery device, the insufflation technique and individual patient factors play an important role in tolerability and efficacy when using IN ketamine for TRD.

Modern Anesthetics

Modern Anesthetics
Author: Jürgen Schüttler,Helmut Schwilden
Publsiher: Springer Science & Business Media
Total Pages: 498
Release: 2008-01-08
ISBN 10: 9783540748069
ISBN 13: 3540748067
Language: EN, FR, DE, ES & NL

Modern Anesthetics Book Review:

Some important constraints of anesthesia must be taken into consideration when the pharmacological properties of modern anesthetics are discussed. The most imp- tant of these could be that the target effect be achieved preferably within seconds, at most within a few minutes. Similarly, offset of drug action should be achieved within minutes rather hours. The target effects, such as unconsciousness, are pot- tially life-threatening, as are the side effects of modern anesthetics, such as respi- tory and cardiovascular depression. Finally, the patient’s purposeful responses are not available to guide drug dosage, because, either the patient is unconscious, or more problematically, the patient is aware but unable to communicate pain because of neuromuscular blockade. These constraints were already recognised 35 years ago, when in 1972 Volume XXX entitled “Modern Inhalation Anesthetics” appeared in this Handbook Series. The present volume is meant as a follow up and extension of that volume. At the beginning of the 1970’s anesthesia was commonly delivered by inhalation, with only very few exceptions. The clinical understanding of that time considered anesthesia as a unique state achieved by any of the inhalation anesthetics, in- pendent of their specific molecular structure. “The very mechanism of anesthetic action at the biophase” was discussed within the theoretical framework of the “u- tary theory of narcosis”.

11 THE USE OF SUBCUTANEOUS KETAMINE FOR TREATMENT RESISTANT DEPRESSION

11   THE USE OF SUBCUTANEOUS KETAMINE FOR TREATMENT RESISTANT DEPRESSION
Author: Mariane Quieroti Rodrigues
Publsiher: Unknown
Total Pages: 329
Release: 2017
ISBN 10:
ISBN 13: OCLC:1163811374
Language: EN, FR, DE, ES & NL

11 THE USE OF SUBCUTANEOUS KETAMINE FOR TREATMENT RESISTANT DEPRESSION Book Review:

Introduction: Major depressive disorder is highly common with up to 50% to 60% of the patients not achieving adequate response following antidepressant treatment. In this scenario, ketamine emerges as an important alternative to conventional treatments, with its action of being an antagonist of N-methyl- D-aspartate (NMDA) receptor, once its has a quick and effective action. Ketamine is most frequently administered intravenous. However, oral, sublingual, transmucosal, intranasal, subcutaneous (SC), and intramuscular routes of administration have also been examined.Aim: This study aims to investigate whether SC ketamine is effective in the treatment of unipolar major depression and if it has more effective and sustainable response than electroconvulsivetherapy (ECT).Methods: Participants will be comprised of patients with unipolar depression resistant to conventional treatment, men and women, aged u2265 18 across a range of ethnicities, recruited from General Hospital Servidor of State of Su00e3o Paulo, Brazil. Participants will be separeted in two groups. The first one will recieve a SC administration of ketamine in the dose of 0,5mg/kg weekly, for 6 weeks. The second will be submitted to ECT treatment, two sessions a week, for at least 8 sessions. The response of each treatment will be evaluated and compared by MADRS questionnaire.Results: We expect that SC ketamine has a good response in the treatment of major depression and that it has a similar response compared to ECT.Conclusion: SC ketamine, once it is a secure, quick and simple procedure, is a promising alternative to the available treatments.

Depression From Psychopathology to Pharmacotherapy

Depression  From Psychopathology to Pharmacotherapy
Author: J.F. Cryan,B.E. Leonard
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 282
Release: 2010-11-17
ISBN 10: 3805596065
ISBN 13: 9783805596060
Language: EN, FR, DE, ES & NL

Depression From Psychopathology to Pharmacotherapy Book Review:

Despite the availability of antidepressants for over 40 years, a substantial proportion of depressed patients do not respond adequately to treatment. Failure to respond effectively to treatment contributes to physical ill-health and psychiatric morbidity, often resulting in premature death of the depressed patient. The purpose of this volume is to consider the possible reasons for the limitations of the currently available antidepressants, to examine the advances in our understanding of the psychopathology of depression and how such knowledge may assist in the discovery of new methods of treatment. Leading international experts in this field discuss the possible underlying reasons for depression and limitations of current antidepressants. Opportunities for novel therapeutic approaches to dysfunctional circadian rhythms and mood disorders as well as current status and future perspectives for optimizing antidepressant management of depression are reviewed. This publication illustrates the breadth of the latest research and is valuable reading for psychiatrists, neuroscientists and pharmacologists.

Bipolar Not So Much Understanding Your Mood Swings and Depression

Bipolar  Not So Much  Understanding Your Mood Swings and Depression
Author: Chris Aiken,James Phelps
Publsiher: W. W. Norton & Company
Total Pages: 368
Release: 2017-01-17
ISBN 10: 0393711757
ISBN 13: 9780393711752
Language: EN, FR, DE, ES & NL

Bipolar Not So Much Understanding Your Mood Swings and Depression Book Review:

Approaching depression as a complex disorder with many different facets rather than all-or-nothing. Depression confuses the mind, strips away hope, and causes people to blame themselves for an illness they never asked for. This book presents a revolutionary new understanding of the concept of depression and offers readers skills and strategies to manage it. No longer is this a one-size-fits-all diagnosis, and antidepressants are no longer the one-size-fits-all treatment. Mood disorders are now seen to form a spectrum of problems, from common depression on one end to full bipolar disorder on the other. In between these extremes are multitudes of people who are on the middle of the mood spectrum, and this book is for them. The first part of the book helps readers answer the question, “Where am I on the mood spectrum?” By laying the foundation for understanding this spectrum, Aiken and Phelps highlight the key distinctions that define unipolarity, bipolarity, hypomania, mania, and depression. Readers will be able to discern which definition best fits their experience, and use this understanding to learn which treatment methods will work best. The authors also empower readers to look beyond antidepressants. They walk readers through new medications for the mood spectrum, and offer a guide to non-medication treatments that anyone can use on their own, from diet and lifestyle changes to natural supplements. The book also discusses other innovative technologies that can aid in recovery, including dawn simulators, mood apps, and blue-light filters. This thoughtful and beneficial book will offer readers skills and strategies, as well as hope, in the face of debilitating mental challenges.

The Ketamine Papers

The Ketamine Papers
Author: Kenneth Ring,Stanislav Grof,Ralph Metzner,Stanley Krippner,Eli Kolp,Harris Friedman,Evgeny Krupitsky,Karl Jansen,Mark Sylvester,M. Scott Young,Anna Kolp,Wesley Ryan,Cole Marta,Ralph Koek,Stephen Hyde,Steven Levine,Terrence Early,Jeffrey Becker
Publsiher: Unknown
Total Pages: 448
Release: 2016-11-15
ISBN 10: 9780998276502
ISBN 13: 0998276502
Language: EN, FR, DE, ES & NL

The Ketamine Papers Book Review:

The Ketamine Papers opens the door to a broad understanding of this medicine's growing use in psychiatry and its decades of history providing transformative personal experiences. Now gaining increasing recognition as a promising approach to the treatment of depression, posttraumatic stress disorder (PTSD), and other psychological conditions, ketamine therapies offer new hope for patients and clinicians alike. With multiple routes of administration and practices ranging from anesthesia to psychotherapy, ketamine medicine is a diverse and rapidly growing field. The Ketamine Papers clarifies the issues and is an inspiring introduction to this powerful tool for healing and transformation---from its early use in the 1960s to its emerging role in the treatment of depression, suicidality and other conditions. This comprehensive volume is the ideal introduction for patients and clinicians alike, and for anyone interested in the therapeutic and transformative healing power of this revolutionary medicine.

Pharmacotherapy of Depression

Pharmacotherapy of Depression
Author: Domenic A. Ciraulo,Richard Irwin Shader
Publsiher: Springer Science & Business Media
Total Pages: 423
Release: 2010-12-28
ISBN 10: 9781603274357
ISBN 13: 1603274359
Language: EN, FR, DE, ES & NL

Pharmacotherapy of Depression Book Review:

Comprehensive and state of the art, the second edition of Pharmacotherapy of Depression offers major revisions of every chapter and the addition of new chapters by expert contributors. The first chapter reviews the neurobiology of depression, which lays the groundwork for understanding the mechanisms of action of antidepressants. In the next chapter, a review of the general principles guiding the diagnosis and medication treatment of unipolar depression is provided. The clinical pharmacology of antidepressants is reviewed in some detail, supplemented by tables that provide information on dosing, indications, and metabolism. Augmentation strategies are reviewed, including the use of non-traditional agents. The chapters that follow next address the use of antidepressants in special populations, such as the elderly and depressed individuals with psychosis, bipolar disorder, substance abuse, and post traumatic stress disorder. The complex issues involving the diagnosis and treatment of depression during pregnancy is thoroughly reviewed in Chapter 8 and provides a synthesis of the scientific literature in the area, one that is noted for contradictory and controversial findings, as well as guidelines for prescribing. The next chapter then provides an overview of the treatment of depression in the pediatric population, highlighting clinical concerns such as suicide risk. The book concludes with two chapters at the interface of medicine and psychiatry in the treatment of mood disorders: managing depression in primary care settings and depression associated with medical illnesses. The outstanding clinician-scientists who have contributed to this volume are all leaders in their fields and represent a broad spectrum of renowned institutions. A timely contribution to the literature, The Pharmacotherapy of Depression, Second Edition, offers busy clinicians from many disciplines a strong scientific foundation that seamlessly transitions into practical recommendations for clinical practice. The result is another gold-standard guide to the safe and effective use of the latest antidepressant medications.

The Depression and Bipolar Workbook

The Depression and Bipolar Workbook
Author: Chris Aiken
Publsiher: Pesi Publishing & Media
Total Pages: 329
Release: 2020-02-04
ISBN 10: 9781683732358
ISBN 13: 1683732359
Language: EN, FR, DE, ES & NL

The Depression and Bipolar Workbook Book Review:

Intravenous Ketamine for Adults with Treatment Resistant Depression Or Post Traumatic Stress Disorder A Review of Clinical Effectiveness Cost Effectiveness and Guidelines

Intravenous Ketamine for Adults with Treatment Resistant Depression Or Post Traumatic Stress Disorder  A Review of Clinical Effectiveness  Cost Effectiveness and Guidelines
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 2019
ISBN 10:
ISBN 13: OCLC:1151537743
Language: EN, FR, DE, ES & NL

Intravenous Ketamine for Adults with Treatment Resistant Depression Or Post Traumatic Stress Disorder A Review of Clinical Effectiveness Cost Effectiveness and Guidelines Book Review:

Ketamine

Ketamine
Author: Bita Moghaddam
Publsiher: MIT Press
Total Pages: 208
Release: 2021-02-16
ISBN 10: 026236266X
ISBN 13: 9780262362665
Language: EN, FR, DE, ES & NL

Ketamine Book Review:

The emergence of ketamine--previously known as a combat anesthetic and club drug--as a treatment for depression. Ketamine, approved in 2019 by the Food and Drug Administration for the treatment of depression, has been touted by scientists and media reports as something approaching a miracle cure. This volume in the MIT Press Essential Knowledge series chronicles the ascent of a drug that has been around for fifty years--in previous incarnations, a Vietnam-era combat anesthetic and a popular club drug--that has now been reinvented as a treatment for depression. Bita Moghaddam, a leading researcher in neuropharmacology, explains the scientific history and the biology of ketamine, its clinical use, and its recently discovered antidepressant effects, for the nonspecialist reader.

Ketamine

Ketamine
Author: David T. Yew
Publsiher: CRC Press
Total Pages: 415
Release: 2015-03-16
ISBN 10: 1466583401
ISBN 13: 9781466583405
Language: EN, FR, DE, ES & NL

Ketamine Book Review:

Increasing use of ketamine as a recreational drug in Asia, Europe, and America is a great burden on society at large, leading to aspirational strain, unemployment, and crime. These societal effects have led to growing interest among researchers and clinicians in ketamine’s effects on various systems of the body. Ketamine: Use and Abuse reviews the acute and chronic effects of ketamine on both adult and developing animals and humans. Providing an exhaustive review of the literature, the book is supplemented by the introduction of new data and research. Topics include: The pharmacological properties of ketamine The impact of ketamine on various organ systems, including the central nervous system and the gastrointestinal, respiratory, adrenal, and renal systems Developmental neurotoxicity in the developing brain Postmortem toxicology The epidemiology of misuse and patterns of acute and chronic toxicity The psychosocial aspects of ketamine addiction Clinical applications at acceptable doses, including possible contribution to the treatment of depression The contributions in this book represent an initiative to investigate the different facets of ketamine beyond the known psychosocial factors related to addiction and its traditional use as an anesthetic agent. The broad-based coverage is designed to promote heightened attention on the subject and encourage further research into beneficial clinical uses.

Cognition in Major Depressive Disorder

Cognition in Major Depressive Disorder
Author: Roger S. McIntyre,Danielle S. Cha,Joanna K. Soczynska
Publsiher: OUP Oxford
Total Pages: 128
Release: 2014-05-08
ISBN 10: 0191002623
ISBN 13: 9780191002625
Language: EN, FR, DE, ES & NL

Cognition in Major Depressive Disorder Book Review:

Part of the Oxford Psychiatry Library (OPL) series, Cognition in Major Depressive Disorder provides a succinct summary of cognitive deficits reported in patients with major depressive disorder (MDD) with a particular focus on aspects of measurement, underlying disease pathophysiology, implications for treatment and prevention. This book also provides readers an opportunity for clinical-based assessment of cognition and recommendations for how cognitive measurement and treatment is positioned in the management of individuals with mood disorders.

Treatment Resistant Mood Disorders

Treatment Resistant Mood Disorders
Author: Jay D. Amsterdam,Mady Hornig,Andrew A. Nierenberg
Publsiher: Cambridge University Press
Total Pages: 556
Release: 2007-10-08
ISBN 10: 9780521041812
ISBN 13: 0521041813
Language: EN, FR, DE, ES & NL

Treatment Resistant Mood Disorders Book Review:

This timely book assesses all aspects of treatment-resistant depression and will be invaluable to professionals.