Isocoumarin Thiaisocoumarin and Phosphaisocoumarin

Isocoumarin  Thiaisocoumarin and Phosphaisocoumarin
Author: Sarbani Pal,Manojit Pal
Publsiher: Elsevier
Total Pages: 216
Release: 2018-10-16
ISBN 10: 0128154462
ISBN 13: 9780128154465
Language: EN, FR, DE, ES & NL

Isocoumarin Thiaisocoumarin and Phosphaisocoumarin Book Review:

Isocoumarin, Thiaisocoumarin and Phosphaisocoumarin: Natural Occurrences, Synthetic Approaches and Pharmaceutical Applications gives an overview of the various aspects of this class of heterocycle, with a major focus on synthesis and biological activity. Aromatic δ lactones or isocoumarins with thiaisocoumarins, phosphaisocoumarins and a-pyranone fused with a heteroaryl ring constitute an important class of heterocyclic compounds. This book provides the methods applied for the synthesis of thiaisocoumarins, phosphaisocoumarins, and a-pyranone fused with a heteroaryl ring. It is useful to medicinal and natural product chemists who want to synthesize target molecules and develop cutting-edge technologies to provide better solutions to researchers. Features an overview of isocoumarins and their role in pharmaceutical research Presents a template for the design, discovery and development of new and potential drugs in various therapeutic areas Includes comprehensive coverage of the synthesis of isocoumarins, from traditional methods, to transition metal catalyzed methods Looks at future applications for these important compounds in the areas of drug discovery and pharmaceutical research

Advances in Polymer Chemistry and Methods Reported in Recent US Patents

Advances in Polymer Chemistry and Methods Reported in Recent US Patents
Author: Thomas F. DeRosa
Publsiher: John Wiley & Sons
Total Pages: 760
Release: 2008-09-16
ISBN 10: 0470385987
ISBN 13: 9780470385982
Language: EN, FR, DE, ES & NL

Advances in Polymer Chemistry and Methods Reported in Recent US Patents Book Review:

The objective of this book is to convey to academic and industrial researchers and students advances in synthetic and characterization methods in 9 selected areas of polymer chemistry reported in 2007-2008 US Patents. It reviews the impact of newer bulk anionic, cationic, and free radical polymerization methods within selected industrial applications. Bulk and surface crosslinking agents using selected bi- and tri-functional reagents, photochemical methods, or free radical agents are also reviewed. Finally, there is a separate section on cationic and cationic ring opening polymerization reactions describing di- and tri-heterocyclic monomers and their use in medical devices.

Comprehensive Natural Products III

Comprehensive Natural Products III
Author: Anonim
Publsiher: Elsevier
Total Pages: 4238
Release: 2020-07-22
ISBN 10: 0081026919
ISBN 13: 9780081026915
Language: EN, FR, DE, ES & NL

Comprehensive Natural Products III Book Review:

Comprehensive Natural Products III, Third Edition, updates and complements the previous two editions, including recent advances in cofactor chemistry, structural diversity of natural products and secondary metabolites, enzymes and enzyme mechanisms and new bioinformatics tools. Natural products research is a dynamic discipline at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids and enzymes. This book reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine and to stimulate new ideas among the established natural products community. Provides readers with an in-depth review of current natural products research and a critical insight into the future direction of the field Bridges the gap in knowledge by covering developments in the field since the second edition published in 2010 Split into 7 sections on key topics to allow students, researchers and professionals to find relevant information quickly and easily Ensures that the knowledge within is easily understood by and applicable to a large audience

Tellurium in Organic Synthesis

Tellurium in Organic Synthesis
Author: Nicola Petragnani,Hélio A. Stefani
Publsiher: Elsevier
Total Pages: 398
Release: 2010-07-07
ISBN 10: 9780080474922
ISBN 13: 0080474926
Language: EN, FR, DE, ES & NL

Tellurium in Organic Synthesis Book Review:

The increasing number of publications that use tellurium clearly demonstrates the important role of tellurium compounds as unique and powerful tools in a broad range of organic chemical manipulations, often characterized by their selective behavior. Tellurium in Organic Synthesis provides an overview of the principal aspects of organic tellurium chemistry. Many chapters have been enriched and updated in this second edition. New chapters include overviews of toxicology and pharmacology and a review on the preparation and reactivity of several tellurium heterocycles. The first part of the book focuses on the preparation of selected inorganic tellurium compounds and on the main classes of organotellurium compounds. The second part, and main interest of the book, details the use of these inorganic and organic compounds as reagents to perform specific organic manipulations and synthesis. Reactions covered include reduction, formation and reaction of anionic species, deprotection, tellurium cyclizations, formation of alkenes, use of vinyllic tellurides, free radical chemistry, transmetallations, and removal of tellurium. Overview of inorganic and organic tellurium chemistry Synthetic applications of tellurium compounds All topics accompanied by detailed experimental procedures

Recent Advances in Natural Products Analysis

Recent Advances in Natural Products Analysis
Author: Seyed Mohammad Nabavi,Mina Saeedi,Seyed Fazel Nabavi,Ana Sanches Silva
Publsiher: Elsevier
Total Pages: 878
Release: 2020-03-07
ISBN 10: 0128175192
ISBN 13: 9780128175194
Language: EN, FR, DE, ES & NL

Recent Advances in Natural Products Analysis Book Review:

Recent Advances in Natural Products Analysis is a thorough guide to the latest analytical methods used for identifying and studying bioactive phytochemicals and other natural products. Chemical compounds, such as flavonoids, alkaloids, carotenoids and saponins are examined, highlighting the many techniques for studying their properties. Each chapter is devoted to a compound category, beginning with the underlying chemical properties of the main components followed by techniques of extraction, purification and fractionation, and then techniques of identification and quantification. Biological activities, possible interactions, levels found in plants, the effects of processing, and current and potential industrial applications are also included. Focuses on the latest analytical techniques used for studying phytochemical and other biological compounds Authored and edited by the top worldwide experts in their field Discusses the current and potential applications and predicts future trends of each compound group

Principles of Organic Chemistry

Principles of Organic Chemistry
Author: Robert J. Ouellette,J. David Rawn
Publsiher: Academic Press
Total Pages: 496
Release: 2015-02-13
ISBN 10: 0128026340
ISBN 13: 9780128026342
Language: EN, FR, DE, ES & NL

Principles of Organic Chemistry Book Review:

Class-tested and thoughtfully designed for student engagement, Principles of Organic Chemistry provides the tools and foundations needed by students in a short course or one-semester class on the subject. This book does not dilute the material or rely on rote memorization. Rather, it focuses on the underlying principles in order to make accessible the science that underpins so much of our day-to-day lives, as well as present further study and practice in medical and scientific fields. This book provides context and structure for learning the fundamental principles of organic chemistry, enabling the reader to proceed from simple to complex examples in a systematic and logical way. Utilizing clear and consistently colored figures, Principles of Organic Chemistry begins by exploring the step-by-step processes (or mechanisms) by which reactions occur to create molecular structures. It then describes some of the many ways these reactions make new compounds, examined by functional groups and corresponding common reaction mechanisms. Throughout, this book includes biochemical and pharmaceutical examples with varying degrees of difficulty, with worked answers and without, as well as advanced topics in later chapters for optional coverage. Incorporates valuable and engaging applications of the content to biological and industrial uses Includes a wealth of useful figures and problems to support reader comprehension and study Provides a high quality chapter on stereochemistry as well as advanced topics such as synthetic polymers and spectroscopy for class customization

Hypervalent Iodine in Organic Synthesis

Hypervalent Iodine in Organic Synthesis
Author: A. Varvoglis
Publsiher: Academic Press
Total Pages: 223
Release: 1996-11-14
ISBN 10: 0080534368
ISBN 13: 9780080534367
Language: EN, FR, DE, ES & NL

Hypervalent Iodine in Organic Synthesis Book Review:

This book describes the fascinating chemistry of the many kinds of organic compounds of hypervalent iodine. Each chapter deals with a particular iodine compound or families of compounds which have been used as reagents in a plethora of useful transformations. These include assorted oxidation, such as with the precious Dess-Martin reagent as well as with a wide range of further reactions. Prominent features of hypervalent iodine reagents derived from iodobenzene are: ready availability, operational simplicity, mild reaction conditions, and high efficiency. They are environmentally safe and can be recycled. New species may be easily prepared by introducing substituents in the benzene ring or changing the ligand attached to iodine. Their combination with other reagents broadens considerably their synthetic potential. Today, no synthetic chemist can afford to ignore the valuable hypervalentiodine reagents. Key Features * Features up-to-date coverage of a wide range of topics * Includes many tables featuring a diversity of reactivity, and a comprehensive index * Acts as a comprehensive, up-to-date reference on all aspects of hypervalent iodine chemistry * Contains a section on unusual efficiency of hypervalent iodine reactions

Scientific and Technical Aerospace Reports

Scientific and Technical Aerospace Reports
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 1964
ISBN 10:
ISBN 13: MINN:30000006076701
Language: EN, FR, DE, ES & NL

Scientific and Technical Aerospace Reports Book Review:

Advances in Transition Metal Mediated Heterocyclic Synthesis

Advances in Transition Metal Mediated Heterocyclic Synthesis
Author: Daniel Sole,Israel Fernandez
Publsiher: Academic Press
Total Pages: 366
Release: 2018-05-17
ISBN 10: 0128116528
ISBN 13: 9780128116524
Language: EN, FR, DE, ES & NL

Advances in Transition Metal Mediated Heterocyclic Synthesis Book Review:

Advances in Transition-Metal Mediated Heterocyclic Synthesis provides an overview of recent catalytic reactions involving transition metals to produce heterocyclic compounds. The book is organized according to the type of transformation used to achieve the synthesis of the heterocyclic systems (mainly aza- and oxa-heterocycles). As such, it covers recent applications on the synthesis of heterocycles, also describing the details of the novel transformations in a didactic manner to motivate readers in search of new catalytic processes. The editors have included state-of-the-art strategies, including transition-metal reactions involving unsaturated systems (reactions of allenes, new gold(I)-catalyzed reactions, and Prins reaction). Chapters highlight the versatility of organopalladium chemistry dealing with carbonylative transformations, C-H activation reactions, coupling processes, and the control of the ambiphilic character of organopalladium species. Finally, the book discusses new reactions leading to heterocycles based on C-H activation processes catalyzed by other metals (Rh, Ru, Co). Written by an outstanding team of authors who are leading experts in organometallic chemistry and organic synthesis, this book is a valuable resource not only for chemists mainly focused on synthesis, but also for those interested in reaction mechanisms involving transition metals. Helpfully organized by transformation type to stimulate the search for new synthetic processes Completely illustrated and written by global experts Includes thoughtfully selected strategies chosen by the editors to exemplify the state-of-the-art of the subject, including transition-metal reactions involving unsaturated systems, organopalladium chemistry, and metal-catalyzed C-H activation

Approaches to Design and Synthesis of Antiparasitic Drugs

Approaches to Design and Synthesis of Antiparasitic Drugs
Author: N. Anand,S. Sharma†
Publsiher: Elsevier
Total Pages: 510
Release: 1997-07-10
ISBN 10: 9780080527529
ISBN 13: 0080527523
Language: EN, FR, DE, ES & NL

Approaches to Design and Synthesis of Antiparasitic Drugs Book Review:

This book presents a comprehensive and up to date account of the chemotherapy of parasitic diseases, both human and veterinary. The book starts with an overview of parasitic diseases. The body of the book is divided into two parts: antihelminthic drugs, and antiprotozoal drugs. Both parts start with chapters highlighting the 'biochemical targets' available for chemotherapeutic interference. Individual chapters deal with one chemical class of compounds and describe their origin, structure-activity relationship, mode of action, and methods of synthesis and their status both in clinical and veterinary practice. The book will be useful to a wide spectrum of readers: students embarking on a research career in parasitic chemotherapy, clinicians (and veterinarians) and clinical pharmacologists desiring detailed information about the drugs currently in use, and pharmaceutical technologists wanting to update their knowledge of the methods of manufacture.

Organic Chemistry Study Guide

Organic Chemistry Study Guide
Author: Robert J. Ouellette,J. David Rawn
Publsiher: Elsevier
Total Pages: 614
Release: 2015-04-30
ISBN 10: 012801864X
ISBN 13: 9780128018644
Language: EN, FR, DE, ES & NL

Organic Chemistry Study Guide Book Review:

Organic Chemistry Study Guide: Key Concepts, Problems, and Solutions features hundreds of problems from the companion book, Organic Chemistry, and includes solutions for every problem. Key concept summaries reinforce critical material from the primary book and enhance mastery of this complex subject. Organic chemistry is a constantly evolving field that has great relevance for all scientists, not just chemists. For chemical engineers, understanding the properties of organic molecules and how reactions occur is critically important to understanding the processes in an industrial plant. For biologists and health professionals, it is essential because nearly all of biochemistry springs from organic chemistry. Additionally, all scientists can benefit from improved critical thinking and problem-solving skills that are developed from the study of organic chemistry. Organic chemistry, like any "skill", is best learned by doing. It is difficult to learn by rote memorization, and true understanding comes only from concentrated reading, and working as many problems as possible. In fact, problem sets are the best way to ensure that concepts are not only well understood, but can also be applied to real-world problems in the work place. Helps readers learn to categorize, analyze, and solve organic chemistry problems at all levels of difficulty Hundreds of fully-worked practice problems, all with solutions Key concept summaries for every chapter reinforces core content from the companion book

Medicinal Chemistry of Anticancer Drugs

Medicinal Chemistry of Anticancer Drugs
Author: Carmen Avendano,J. Carlos Menendez
Publsiher: Elsevier
Total Pages: 768
Release: 2015-06-11
ISBN 10: 0444626670
ISBN 13: 9780444626677
Language: EN, FR, DE, ES & NL

Medicinal Chemistry of Anticancer Drugs Book Review:

Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. Presents information in a clear and concise way using a large number of figures Historical background provides insights on how the process of drug discovery in the anticancer field has evolved Extensive references to primary literature

Catalytic Amination for N Alkyl Amine Synthesis

Catalytic Amination for N Alkyl Amine Synthesis
Author: Feng Shi,Xinjiang Cui
Publsiher: Academic Press
Total Pages: 206
Release: 2018-03-14
ISBN 10: 0128122854
ISBN 13: 9780128122853
Language: EN, FR, DE, ES & NL

Catalytic Amination for N Alkyl Amine Synthesis Book Review:

Catalytic Amination for N-Alkyl Amine Synthesis provides a useful survey of this key type of reaction for chemistry researchers in academia and industry. Beginning with an introduction to amination and the development of the field, the book focuses on useful and high potential methods, such as the catalytic amination of alcohol with homogeneous and heterogeneous catalysts, the coupling reaction of olefin and amine, and the reductive amination of carbon dioxide with different reducing agents. The work also discusses two key examples of one-pot synthesis, the oxidative amination of alkane and amine and synthesis of N-alkyl amine with nitrobenzene and nitrile as starting materials. Valuable for chemists, materials scientists, chemical engineers and others, the book offers a unique overview of this growing area and its future possibilities. Describes the catalytic amination of alcohol with homogeneous and heterogeneous catalysts Discusses the one-pot oxidative amination of alkane and amine Explores the application of ammonia as the N-source in amination reaction to avoid primary or secondary amine synthesis

Organic Chemistry

Organic Chemistry
Author: J. David Rawn,Robert J. Ouellette
Publsiher: Academic Press
Total Pages: 1056
Release: 2018-02-03
ISBN 10: 0128128399
ISBN 13: 9780128128398
Language: EN, FR, DE, ES & NL

Organic Chemistry Book Review:

Organic Chemistry: Structure, Mechanism, Synthesis, Second Edition, provides basic principles of this fascinating and challenging science, which lies at the interface of physical and biological sciences. Offering accessible language and engaging examples and illustrations, this valuable introduction for the in-depth chemistry course engages students and gives future and new scientists a new approach to understanding, rather than merely memorizing the key concepts underpinning this fundamental area. The book builds in a logical way from chemical bonding to resulting molecular structures, to the corresponding physical, chemical and biological properties of those molecules. The book explores how molecular structure determines reaction mechanisms, from the smallest to the largest molecules—which in turn determine strategies for organic synthesis. The book then describes the synthetic principles which extend to every aspect of synthesis, from drug design to the methods cells employ to synthesize the molecules of which they are made. These relationships form a continuous narrative throughout the book, in which principles logically evolve from one to the next, from the simplest to the most complex examples, with abundant connections between the theory and applications. Featuring in-book solutions and instructor PowerPoint slides, this Second Edition offers an updated and improved option for students in the two-semester course and for scientists who require a high quality introduction or refresher in the subject. Offers improvements for the two-semester course sequence and valuable updates including two new chapters on lipids and nucleic acids Features biochemistry and biological examples highlighted throughout the book, making the information relevant and engaging to readers of all backgrounds and interests Includes a valuable and highly-praised chapter on organometallic chemistry not found in other standard references

Antimalarial Agents

Antimalarial Agents
Author: Graham L. Patrick
Publsiher: Elsevier
Total Pages: 622
Release: 2020-05-30
ISBN 10: 0081012411
ISBN 13: 9780081012413
Language: EN, FR, DE, ES & NL

Antimalarial Agents Book Review:

Antimalarial Agents: Design and Mechanism of Action seeks to support medicinal chemists in their work towards antimalarial solution, providing practical guidance on current developments and highlighting promising leads for the future. Malaria is a deadly disease which threatens half of the world’s population. Advances over the last decade have seen vast improvements in the effectiveness of both preventative measures and treatments, but the rapid adaptability of the disease means that the ongoing search for improved and novel antimalarial drugs is essential. Beginning with a focus on biological aspects of malaria, this book highlights the lifecycle of the parasite responsible for malaria, the problem of resistance, genetic mapping of the parasite’s genome, established drug targets, and potential drug targets for the future. The book also includes detailed study of the medicinal chemistry of antimalarial agents and a focus on the design of antimalarial drugs. Drawing on the knowledge of its expert authors and coupling historic research with current findings to provide a full picture of both past and current milestones, Antimalarial Agents: Design and Mechanism of Action is a comprehensive yet accessible guide for all those involved in the design, development and administration of antimalarial drugs, including academic researchers, medicinal chemists, malaria researchers and pharmaceutical scientists. Consolidates both past and current developments in the discovery and design of antimalarial drugs Presents content in a style that is both thorough and engaging, providing a supportive and guiding reference to students and researchers from interdisciplinary backgrounds Highlights drug targets currently considered to be the most promising for future therapies, and the classes of compounds that are currently being studied and perfected

Biflavanoids

Biflavanoids
Author: Shabir Hussain Lone,Mohd Akbar Khuroo
Publsiher: Elsevier
Total Pages: 52
Release: 2016-04-14
ISBN 10: 0081011903
ISBN 13: 9780081011904
Language: EN, FR, DE, ES & NL

Biflavanoids Book Review:

Biflavanoids are an important class of plant metabolites offering a range of activities, good availability and relatively low toxicity. Long thought to hold possible therapeutic potential, the recent surge in interest for natural product drug discovery has further highlighted the possibility of using them in the discovery of new drugs, and Biflavanoids: Chemical and Pharmacological Aspects provides a quick reference to the area in a focused manner, to support and encourage further research. Beginning with a focus on the structural features and occurrence of biflavanoids, Chapter 1 reviews key background information including notes on nomenclature and natural distribution. Chapter 2 then goes on to discuss methods for identification and isolation, with separation and purification using various chromatography methods reviewed, followed by identification via UV spectroscopy, NRM spectroscopy and mass spectrometry. Synthesis is the focus of Chapter 3, with a broad range of synthetic methods outlined, before the book concludes in Chapter 4 by describing the biochemical pharmacology of Biflavanoids and their anticancer, antimicrobial, antiviral, anti-inflammatory and analgesic activity. With its discussion of both the underlying chemistry and biological activity of Biflavanoids, Biflavanoids: Chemical and Pharmacological Aspects is a concise guide to this important class of compounds for all those working in the fields of medicinal chemistry and natural products drug discovery. Focused coverage of techniques for the isolation, identification, and synthesis of Biflavanoids Practical tool for researchers working with these flavonoid compounds Real-world expertise from the authors provides support for further developments in the growing field of natural product drug discovery Useful, clear illustrations of key structures throughout the text

Fluorescent Analogs of Biomolecular Building Blocks

Fluorescent Analogs of Biomolecular Building Blocks
Author: Marcus Wilhelmsson,Yitzhak Tor
Publsiher: John Wiley & Sons
Total Pages: 448
Release: 2016-03-16
ISBN 10: 1119179343
ISBN 13: 9781119179344
Language: EN, FR, DE, ES & NL

Fluorescent Analogs of Biomolecular Building Blocks Book Review:

Fluorescent Analogs of Biomolecular Building Blocks focuses on the design of fluorescent probes for the four major families of macromolecular building blocks. Compiling the expertise of multiple authors, this book moves from introductory chapters to an exploration of the design, synthesis, and implementation of new fluorescent analogues of biomolecular building blocks, including examples of small-molecule fluorophores and sensors that are part of biomolecular assemblies.

Green Synthetic Approaches for Biologically Relevant Heterocycles

Green Synthetic Approaches for Biologically Relevant Heterocycles
Author: Goutam Brahmachari
Publsiher: Elsevier
Total Pages: 632
Release: 2014-11-17
ISBN 10: 0128005904
ISBN 13: 9780128005903
Language: EN, FR, DE, ES & NL

Green Synthetic Approaches for Biologically Relevant Heterocycles Book Review:

Green Synthetic Approaches for Biologically Relevant Heterocycles reviews this significant group of organic compounds within the context of sustainable methods and processes. Each clearly structured chapter features in-depth coverage of various green protocols for the synthesis of a wide variety of bioactive heterocycles classified on the basis of ring-size and/or presence of heteratoms(s). Techniques covered include microwave heating, ultrasound, ionic liquids, solid phase, solvent-free, heterogeneous catalysis, and aqueous media, along with multi-component reaction strategies. This book also integrates advances in green chemistry research into industrial applications and process developments. Green Synthetic Approaches for Biologically Relevant Heterocycles is an essential resource on green chemistry technologies for academic researchers, R&D professionals, and students working in medicinal, organic, natural product, and agricultural chemistry. Includes global coverage of a wide variety of green synthetic techniques Features cutting-edge research in the field of bioactive heterocyclic compounds Focuses extensively on applications, with numerous examples of biologically relevant heterocycles

Heterocyclic Chemistry in Drug Discovery

Heterocyclic Chemistry in Drug Discovery
Author: Jie Jack Li
Publsiher: John Wiley & Sons
Total Pages: 720
Release: 2013-04-26
ISBN 10: 1118354435
ISBN 13: 9781118354438
Language: EN, FR, DE, ES & NL

Heterocyclic Chemistry in Drug Discovery Book Review:

Enables researchers to fully realize the potential to discover new pharmaceuticals among heterocyclic compounds Integrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why these two fields go hand in hand in the effective practice of medicinal chemistry. Contributions from international leaders in the field review more than 100 years of findings, explaining their relevance to contemporary drug discovery practice. Moreover, these authors have provided plenty of practical guidance and tips based on their own academic and industrial laboratory experience, helping readers avoid common pitfalls. Heterocyclic Chemistry in Drug Discovery is ideal for readers who want to fully realize the almost limitless potential to discover new and effective pharmaceuticals among heterocyclic compounds, the largest and most varied family of organic compounds. The book features: Several case studies illustrating the role and application of 3, 4, 5, and 6+ heterocyclic ring systems in drug discovery Step-by-step descriptions of synthetic methods and practical techniques Examination of the physical properties for each heterocycle, including NMR data and quantum calculations Detailed explanations of the complexity and intricacies of reactivity and stability for each class of heterocycles Heterocyclic Chemistry in Drug Discovery is recommended as a textbook for organic and medicinal chemistry courses, particularly those emphasizing heterocyclic chemistry. The text also serves as a guide for medicinal and process chemists in the pharmaceutical industry, offering them new insights and new paths to explore for effective drug discovery.

Heteroatom Manipulation

Heteroatom Manipulation
Author: E. Winterfeldt
Publsiher: Elsevier
Total Pages: 1217
Release: 1992-09-08
ISBN 10: 0080912494
ISBN 13: 9780080912493
Language: EN, FR, DE, ES & NL

Heteroatom Manipulation Book Review:

In this volume, those functional groups containing heteroatoms that have gained importance in organic synthesis are dealt with in detail. The introduction of these various groups and their relevant transformations are described and the various aspects of chemoselectivity, regioselectivity and stereoselectivity are discussed. After a compilation of the synthetically most useful substitution processes, there is a series of chapters on the various types of acylation reactions and in this context the different methods of acyl group activation are discussed. As functional group protection is of very general importance for organic synthesis, a corresponding chapter is included. This is followed by a section on the preparation of carbonyl derivatives and the most important transformations and rearrangements of functional group derivatives. At the end of the volume one finds chapters on all types of elimination reactions and related thermal reactions together with a survey on fragmentation processes in organic synthesis.