Methods in iPSC Technology

Methods in iPSC Technology
Author: Alexander Birbrair
Publsiher: Academic Press
Total Pages: 370
Release: 2021-06-15
ISBN 10: 0323856446
ISBN 13: 9780323856447
Language: EN, FR, DE, ES & NL

Methods in iPSC Technology Book Review:

Methods in iPSC Technology, Volume Nine in the Advances in Stem Biology series, addresses the methods used for induced pluripotent stem cell formation, maintenance, expansion and differentiation. The ability to reprogram different cell types to induced pluripotent stem cells offers an opportunity to generate pluripotent patient-specific cell lines that can help in the understanding of multiple human disorders. This volume addresses a variety of methods used with iPSCs, such as magnetic nanoparticles, combining bioscaffolds, hiPSC expansion and differentiation, biomaterials for iPSCs, CRISPR/Cas9, and much more. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field. Ideal for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation Presents a comprehensive solution for both graduate and undergraduate students in a variety of fields of study

Human Embryonic Stem Cells

Human Embryonic Stem Cells
Author: Arlene Chiu,Mahendra S. Rao
Publsiher: Springer Science & Business Media
Total Pages: 461
Release: 2003-08-01
ISBN 10: 1592594239
ISBN 13: 9781592594238
Language: EN, FR, DE, ES & NL

Human Embryonic Stem Cells Book Review:

A discussion of all the key issues in the use of human pluripotent stem cells for treating degenerative diseases or for replacing tissues lost from trauma. On the practical side, the topics range from the problems of deriving human embryonic stem cells and driving their differentiation along specific lineages, regulating their development into mature cells, and bringing stem cell therapy to clinical trials. Regulatory issues are addressed in discussions of the ethical debate surrounding the derivation of human embryonic stem cells and the current policies governing their use in the United States and abroad, including the rules and conditions regulating federal funding and questions of intellectual property.

iPSCs for Studying Infectious Diseases

iPSCs for Studying Infectious Diseases
Author: Alexander Birbrair
Publsiher: Academic Press
Total Pages: 332
Release: 2021-05-29
ISBN 10: 0128241896
ISBN 13: 9780128241899
Language: EN, FR, DE, ES & NL

iPSCs for Studying Infectious Diseases Book Review:

The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. iPSCs for Studying Infectious Diseases, Volume 8 addresses how important induced pluripotent stems cells are and how can they can help treat certain infectious diseases. Somatic cells can be reprogrammed into induced pluripotent stem cells by the expression of specific transcription factors. These cells have been transforming biomedical research over the last 15 years. This volume will address the advances in research of how induced pluripotent stem cells are being used for treatment of different infectious diseases, such as corona virus, coxsackievirus, salmonella infection, influenza virus and much more. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of stem cell biology and function, regenerative medicine, and therapeutics Covers infections by several pathogens, such as coronavirus, coxsackievirus, influenza virus, herpes simplex virus 1, T. gondii, T. cruzi, S. agalactiae, N. meningitidis, Salmonella, and more Is contributed by world-renowned experts in the field

Recent Advances in iPSC Derived Cell Types

Recent Advances in iPSC Derived Cell Types
Author: Alexander Birbrair
Publsiher: Academic Press
Total Pages: 282
Release: 2021-02-21
ISBN 10: 0128224541
ISBN 13: 9780128224540
Language: EN, FR, DE, ES & NL

Recent Advances in iPSC Derived Cell Types Book Review:

The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Recent Advances in iPSC-derived Cell Types, Volume 4 addresses how different cell types can be derived from induced pluripotent stem cells. Somatic cells can be reprogrammed into Induced pluripotent stem cells by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. The volume teaches readers about current advances in the field. This book describes the use of induced pluripotent stem cells to form different cell types which can be used in cell therapy as well as to model several diseases in vitro, enabling us to study the cellular and molecular mechanisms involved in different pathologies. In recent years, remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cellular populations, tissues and organs using state-of-art techniques. This volume will cover what we know so far about the use of iPSCs to derive different cell types, such as: erythroid cells, mucosal-associated invariant T cells, megakaryocytes, cerebral cortical neurons, inner ear cell types, airway epithelial cells, male germ cells, trophoblasts, cardiomyocytes, ßpancreatic cells, and more. The volume is written for researchers and scientists interested in stem cell therapy, cell biology, regenerative medicine, and organ transplantation; and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of induced pluripotent stem cell technology, regenerative medicine and therapeutics. Covers the following cell types derived from iPSCs: erythroid cells, mucosal-associated invariant T cells, megakaryocytes, cerebral cortical neurons, inner ear cell types, airway epithelial cells, male germ cells, trophoblasts, cardiomyocytes, ßpancreatic cells, and more. Contributions from stem cell leaders around the world

Induced Pluripotent Stem Cells in Brain Diseases

Induced Pluripotent Stem Cells in Brain Diseases
Author: Vivi M. Heine,Stephanie Dooves,Dwayne Holmes,Judith Wagner
Publsiher: Springer Science & Business Media
Total Pages: 59
Release: 2011-11-23
ISBN 10: 9789400728165
ISBN 13: 9400728166
Language: EN, FR, DE, ES & NL

Induced Pluripotent Stem Cells in Brain Diseases Book Review:

Brain diseases can have a large impact on patients and society, and treatment is often not available. A new approach in which somatic cells are reprogrammed into induced pluripotent cells (iPS cells) is a significant breakthrough for regenerative medicine. This promises patient-specific tissue for replacement therapies, as well as disease-specific cells for developmental modeling and drug treatment screening. However, this method faces issues of low reprogramming efficiency, and poorly defined criteria for determining the conversion of one cell type to another. Cells contain epigenetic “memories” of what they were that can affect reprogramming. This book discusses the various methods to reprogram cells, the control and determination of cell identity, the epigenetic models that have emerged and the application of iPS cell therapy for brain diseases, in particular Parkinson’s disease and Vanishing White Matter (VWM).​

Recent Advances in iPSCs for Therapy

Recent Advances in iPSCs for Therapy
Author: Alexander Birbrair
Publsiher: Academic Press
Total Pages: 368
Release: 2021-01-30
ISBN 10: 032385186X
ISBN 13: 9780323851862
Language: EN, FR, DE, ES & NL

Recent Advances in iPSCs for Therapy Book Review:

The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Recent Advances in iPSCs for Therapy, Volume 3 addresses the use of induced pluripotent stem cells for therapy of several disorders. The volume teaches the reader about the biology of induced pluripotent stem cells and their possible use as cell therapy. Remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cell types, tissues and organs using state-of-art techniques. This volume will cover what we know so far about the use of iPSCs for therapy of multiple diseases, such as: hair loss disorders, Parkinson’s disease, Huntington’s disease, ischemic stroke, Alzheimer’s disease, Glaucoma, Optic Neuropathy, Age-Related Macular Degeneration, Type 1 Diabetes, Heart Failure, liver diseases, infertility, Autoimmune Diseases, and more. The volume is written for researchers and scientists interested in cell therapy, stem cell biology, regenerative medicine, and organ transplantation and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of stem cell biology and function, regenerative medicine, and therapeutics Covers the possible use of iPSCs for hair loss disorders, Parkinson’s disease, Huntington’s disease, ischemic stroke, Alzheimer’s disease, Glaucoma, Optic Neuropathy, Age-Related Macular Degeneration, Type 1 Diabetes, Heart Failure, liver diseases, infertility, Autoimmune Diseases, and more Contributions from stem cell leaders around the world

Recent Advances in iPSC Disease Modeling Volume 1

Recent Advances in iPSC Disease Modeling  Volume 1
Author: ALEXANDER BIRBRAIR
Publsiher: Academic Press
Total Pages: 320
Release: 2020-07-16
ISBN 10: 0128232692
ISBN 13: 9780128232699
Language: EN, FR, DE, ES & NL

Recent Advances in iPSC Disease Modeling Volume 1 Book Review:

Recent Advances in iPSC Disease Modeling, Volume 1 addresses how induced pluripotent stem cells can be used to model various diseases. Somatic cells are reprogrammed into induced pluripotent stem cells by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. This volume teaches readers about current advances in the field. This book describes the use of induced pluripotent stem cells to model several diseases in vitro, enabling us to study the cellular and molecular mechanisms involved in different pathologies. Further insights into these mechanisms will have important implications for our understanding of disease appearance, development, and progression. In recent years, remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cell types, tissues, and organs using state-of-art techniques. These advantages facilitated identification of key targets and definition of the molecular basis of several disorders. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of induced pluripotent stem cell technology, regenerative medicine, and therapeutics Covers the following diseases: severe congenital neutropenia, sickle cell and Diamond-Blackfan anemias, muscular dystrophies, Bernard-Soulier syndrome, familial hypercholesterolemia type II A, Werner syndrome, lysosomal storage diseases, and more Contains description of cutting-edge research on the development of disease-specific human pluripotent stem cells. These cells allow us to study cellular and molecular processes involved in several human diseases

Perinatal Stem Cells

Perinatal Stem Cells
Author: Zhong Chao Han,Tsuneo A. Takahashi,Zhibo Han,Zongjin Li
Publsiher: Springer
Total Pages: 173
Release: 2019-03-06
ISBN 10: 9811327033
ISBN 13: 9789811327032
Language: EN, FR, DE, ES & NL

Perinatal Stem Cells Book Review:

This book provides a comprehensive introduction to various types of perinatal stem cells. Given their unique regenerative abilities, stem cells offer a promising avenue in the treatment of degenerative diseases or injury. Currently, the limitations of postnatal cell sources and expanding efficiency may limit autologous stem cell therapies. Although embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) can be cultured indefinitely ex vivo, and can differentiate into three germ layers, ethical issues, the teratoma formation of ESCs and oncogenic risk of iPSCs are major obstacles to their clinical application. More recently, perinatal stem cells have been isolated from the umbilical cord, Wharton’s Jelly, placenta, amniotic membrane and amniotic fluid, which are normally discarded as medical waste. This book, after describing perinatal stem cells in detail, introduces readers to the various types of perinatal stem cells, addressing their characterization, banking, quality control and stability. Importantly, it also reviews the clinical applications of perinatal stem cells to therapy of diseases. Accordingly, it offers a valuable resource for clinicians, researchers and graduate students alike.

Stem Cells and Cancer Stem Cells Volume 4

Stem Cells and Cancer Stem Cells  Volume 4
Author: M.A. Hayat
Publsiher: Springer Science & Business Media
Total Pages: 319
Release: 2012-02-07
ISBN 10: 940072828X
ISBN 13: 9789400728288
Language: EN, FR, DE, ES & NL

Stem Cells and Cancer Stem Cells Volume 4 Book Review:

Vast therapeutic applications of the following specific stem cells in disease and tissue injury are discussed: embryonic stem cells, induced pluripotent stem cells, human hair follicle stem cells, bone marrow-derived human mesenchymal stem cells, adipose-derived stem cells, periodontal/progenitor cells, cancer stem cells, and breast cancer stem cells. Because human embryonic stem cells possess the potential to produce unlimited quantities of any human cell type, considerable focus is placed on this type of stem cells in this volume. The role of cancer stem cells, specifically in breast cancer is explained. Transplantation of mesenchymal stem cells to aid the injured brain is included. Immune recovery after stem cells transplantation in severe combined immunodeficiency patients is described. The role of mesenchymal stem cells in enhancing the growth and metastasis of colon cancer is discussed. Clinical application of human follicle stem cells is presented. Treatment of malignant gliomas using genetically-modified neural stem cells as a marker is discussed. The impact of cancer stem cell hypothesis on designing new cancer therapies is explained. In the field of regenerative medicine, the use of stem cells in the repair of the central nervous system, tendon injury, and as a cardiac regenerative medicine is described. The role of DNA methylation in maintaining stemness induced pluripotent stem cells from human extraembryonic amnion cells is discussed. Insights on the understanding of molecular pathways involved in tumor biology are explained, which lead to the development of effective drugs. Information on pathways, such as hedgehog, facilitates targeted therapies in cancer.

iPS Cells for Modelling and Treatment of Human Diseases

iPS Cells for Modelling and Treatment of Human Diseases
Author: Michael J. Edel
Publsiher: MDPI
Total Pages: 422
Release: 2018-10-02
ISBN 10: 3038421227
ISBN 13: 9783038421221
Language: EN, FR, DE, ES & NL

iPS Cells for Modelling and Treatment of Human Diseases Book Review:

This book is a printed edition of the Special Issue "iPS Cells for Modelling and Treatment of Human Diseases" that was published in JCM

Pluripotent Stem Cells

Pluripotent Stem Cells
Author: Deepa Bhartiya,Nibedita Lenka
Publsiher: BoD – Books on Demand
Total Pages: 640
Release: 2013-08-28
ISBN 10: 9535111922
ISBN 13: 9789535111924
Language: EN, FR, DE, ES & NL

Pluripotent Stem Cells Book Review:

Stem cells have generated a lot of excitement among the researchers, clinicians and the public alike. Various types of stem cells are being evaluated for their regenerative potential. Marginal benefit resulting by transplanting autologus stem cells (deemed to be absolutely safe) in various clinical conditions has been proposed to be a growth factor effect rather than true regeneration. In contrast, various pre-clinical studies have been undertaken, using differentiated cells from embryonic stem cells or induced pluripotent stem cells have shown promise, functional improvement and no signs of teratoma formation. The scientists are not in a rush to reach the clinic but a handful of clinical studies have shown promise. This book is a collection of studies/reviews, beginning with an introduction to the pluripotent stem cells and covering various aspects like derivation, differentiation, ethics, etc., and hence would provide insight into the recent standing on the pluripotent stem cells biology. The chapters have been categorized into three sections, covering subjects ranging from the generation of pluripotent stem cells and various means of their derivation from embryonic as well as adult tissues, the mechanistic understanding of pluripotency and narrating the potential therapeutic implications of these in vitro generated cells in various diseases, in addition to the associated pros and cons in the same.

Stem Cell Processing

Stem Cell Processing
Author: Phuc Van Pham
Publsiher: Springer
Total Pages: 225
Release: 2016-10-18
ISBN 10: 3319400738
ISBN 13: 9783319400730
Language: EN, FR, DE, ES & NL

Stem Cell Processing Book Review:

This invaluable resource delineates procedures for development and use of stem cells in the laboratory and explores the potential for clinical applications. The text discusses mesenchymal stem cell isolation, isolation of adipose derived stem cells, new trends of induced pluripotent stem cells in disease treatment, cord blood banking, future directions of the discussed therapies and much more. The chapters are contributed by preeminent scientists in the field and present a comprehensive picture of stem cell processes, from development in the laboratory to effects and side-effects of clinical application. Stem Cell Processing and the other books in the Stem Cells in Clinical Applications series, edited by Dr. Phuc Van Pham, is essential reading for scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering.

Generation of Vasculogenic Progenitor Cells from Human Induced Pluripotent Stem Cells for the Treatment of Cardiovascular Diseases

Generation of Vasculogenic Progenitor Cells from Human Induced Pluripotent Stem Cells for the Treatment of Cardiovascular Diseases
Author: Wing-Hon Kevin Lai,黎永漢
Publsiher: Open Dissertation Press
Total Pages: 135
Release: 2017-01-26
ISBN 10: 9781361338261
ISBN 13: 1361338261
Language: EN, FR, DE, ES & NL

Generation of Vasculogenic Progenitor Cells from Human Induced Pluripotent Stem Cells for the Treatment of Cardiovascular Diseases Book Review:

This dissertation, "Generation of Vasculogenic Progenitor Cells From Human Induced Pluripotent Stem Cells for the Treatment of Cardiovascular Diseases" by Wing-hon, Kevin, Lai, 黎永漢, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Pluripotent stem cells hold great promise in regenerative medicine. Theoretically, a variety of tissues can be generated from this progeny. The production of tailor-made stem cells for individualized patient treatment is the ultimate goal of stem cell based therapy. Human induced pluripotent stem cells (iPSCs) hold the precious key to success and promote the clinical application of stem cells. By reprogramming somatic cells, pluripotent stem cells can be generated in a patient-specific manner and subsequently differentiated into specific tissue for regeneration. Nonetheless exposure of hiPSCs to animal feeder cells and serum during generation and maintenance imposes a risk of transmitting animal pathogens to human subjects, thus hindering their potential therapeutic application. In addition, the efficacy of iPSC generation is Specific tissue or cells derived from stem cells may offer a solution and cell therapy using endothelial cells and their progenitors may be possible in treatment of severe cardiovascular diseases. In theory, endothelial cells can be generated from different sources of progenitor cells although no direct comparison of these various derived endothelial cells (ECs) has been reported. Thus in the second part of the study, the functional and physiological properties of BM, ESC and iPSC-ECs will be evaluated to determine their therapeutic potential in ischemic disease. A mouse hind limb ischemia model was used to assess and monitor neovascularization by the derived ECs. The results can provide further insight to evaluate the possibility of using iPSCEC as the cell source for patient-specific treatment. Use of pluripotent stem cells is a promising approach in therapeutic angiogenesis although numerous hurdles continue to hamper their widespread clinical use. Conditioned medium derived from progenitor cells may be another possible strategy in the treatment of ischemic diseases such that direct cell transplantation is avoided. Conditioned media produced from ex vivo culture of endothelial cells contain a combination of angiogenic factors that can be applied to promote neovascularization in ischemic tissue. Nonetheless the efficacy of this angiogenic application is unknown. The third part of the study focused on the potential application of EC-derived conditioned media in the treatment of ischemic disease using a mouse hind limb ischemia model. Some cardiovascular risk factors such as diabetes might affect endothelial cell function such that autologous application of ECs and their conditioned media is not feasible. A human embryonic stem cell line may offer and alternative means to obtain stable quality ECs and conditioned medium for therapeutic use. In summary, advances in stem cell technology hold great promise for the treatment of cardiovascular disease, further improved by the generation of patient-specific stem cells using iPSC technology. Vascular cells can be generated from different sources of stem cells with similar angiogenic properties and may be used in the treatment of ischemic diseases. DOI: 10.5353/th_b5185944 Subjects: Cardiovascular system - Disea

Pluripotent Stem Cells

Pluripotent Stem Cells
Author: Minoru Tomizawa
Publsiher: BoD – Books on Demand
Total Pages: 532
Release: 2016-07-20
ISBN 10: 9535124714
ISBN 13: 9789535124719
Language: EN, FR, DE, ES & NL

Pluripotent Stem Cells Book Review:

Pluripotent stem cells have distinct characteristics: self-renewal and the potential to differentiate into various somatic cells. In recent years, substantial advances have been made from basic science to clinical applications. The vast amount knowledge available makes obtaining concise yet sufficient information difficult, hence the purpose of this book. In this book, embryonic stem cells, induced pluripotent stem cells, and mesenchymal stem cells are discussed. The book is divided into five sections: pluripotency, culture methods, toxicology, disease models, and regenerative medicine. The topics covered range from new concepts to current technologies. Readers are expected to gain useful information from expert contributors.

Stem Cells and Cancer Stem Cells Volume 12

Stem Cells and Cancer Stem Cells  Volume 12
Author: M.A. Hayat
Publsiher: Springer Science & Business Media
Total Pages: 256
Release: 2014-02-20
ISBN 10: 9401780323
ISBN 13: 9789401780322
Language: EN, FR, DE, ES & NL

Stem Cells and Cancer Stem Cells Volume 12 Book Review:

Volume 12 in this series explores the latest experimental and clinical uses of stem cells in the treatment of disease and of injuries and reviews methods for isolating multipotent endothelial-like cells from human adipose tissue and discusses clinical applications in cell therapy and regenerative medicine. The book is organized in five parts: Cancer Stem Cells, Pluripotent Stem Cells, Dendritic Stem Cells, Regenerative Medicine and General Applications. The first section includes chapters on histamine in the neural and cancer stem cell niches and emerging concepts of stem cell organization in the normal lung and in lung cancer. The section on Pluripotent Stem Cells includes discussion of the differentiation of dendritic cells from human induced pluripotent stem cell and the molecular mechanisms involved in reprogramming human somatic cells to generate induced pluripotent stem cells. Additional chapters cover the differentiation of induced pluripotent stem cells into functional cardiomyocytes, characteristics of satellite cells and multipotent adult stem cells in the skeletal muscle. The section on Dendritic Stem Cells explores the critical role of notch signaling in the differentiation and function of dendrite. Other chapters cover hypertensive emergencies in children after stem cell transplantation and overcoming the radio resistance of lung cancer stem cells. The section on Regenerative Medicine reports on experiments on improved renal revascularization in pigs using stem cells and phenotypic correction of murine Hemophilia A using cell-based therapy. The concluding section, General Applications, discusses such topics as methods in mathematical modeling for stem cells, as well as molecular and functional characterization of human adipocytes. Like its eleven predecessors in the series, this volume stands out for its comprehensive approach, its roster of some 51 expert contributors representing a dozen different countries and its up-to-date review of leading-edge technology and methods.

Stem Cell Therapy for Parkinson s Disease

Stem Cell Therapy for Parkinson s Disease
Author: Fabin Han
Publsiher: Unknown
Total Pages: 135
Release: 2016
ISBN 10: 1928374650XXX
ISBN 13: OCLC:1154181431
Language: EN, FR, DE, ES & NL

Stem Cell Therapy for Parkinson s Disease Book Review:

Parkinson's disease (PD) is the second most common neurodegenerative disorder of aging after Alzheimer's disease (AD). Pathologically, it is characterized by a degeneration of dopamine (DA) neurons in substantia nigra of middle brain, which causes the motor symptoms and nonmotor symptoms of PD. The dopamine replacement therapy using levodopa and surgical treatment of deep brain stimulation (DBS) can only improve the symptoms of PD, but cannot stop the disease progression. Because of the selective loss of DA neurons, cell transplantation provides an exciting potential for the treatment of Parkinson's disease. The available cell sources include mesenchymal stem cells (MSCs) from bone marrow, neural stem cells (NSCs) from fetal brain tissues, embryonic stem cells (ESCs) from blastocysts, and induced pluripotent stem cells (iPSCs) reprogrammed from somatic cells transfected with stem cell transcription factors of OCT4, SOX2, KLF4, and c-MYC. Here, we first review the research advance conducted in animal models and patients of PD with these cells, then moving forward to recent development of iPSCs as a future source for the treatment of PD, and highlight the current challenges to make good manufacturing practice (GMP) standard cells suitable for large-scale production to move the cell-based therapy from dish to clinic as soon as possible.

Stem Cells and Cancer Stem Cells Volume 7

Stem Cells and Cancer Stem Cells  Volume 7
Author: M.A. Hayat
Publsiher: Springer Science & Business Media
Total Pages: 278
Release: 2012-06-12
ISBN 10: 9400742851
ISBN 13: 9789400742857
Language: EN, FR, DE, ES & NL

Stem Cells and Cancer Stem Cells Volume 7 Book Review:

The seventh in Springer’s landmark series of edited volumes on one of the highest-profile subjects in contemporary medicine and scientific endeavour, this volume sets out to cover a staggering range of research into the medical applications of stem cell research. While stem cells are the very stuff of life for multicellular organisms, including us humans, the cancer stem cell is a morbid entity with a robust resistance to therapies including conventional chemotherapy. This authoritative publication explains the regenerative potential of stem cells and their mesenchymal progeny, reviewing clinical applications of the latter in the treatment of cancer, diabetes and neurodegenerative pathologies. It covers the entire range of stem cells with known potential for therapeutic use, from human embryonic to germ cell-derived pluripotent stem cells and hematopoietic stem cells. The chapters also deal with the role of TGF-beta in propagating human embryonic stem cells, and in facilitating their differentiation. Featuring discussions of molecular signaling pathways that modulate mesenchymal stem cell self-renewal and much more, this book is certain to have broad appeal among academicians and physicians alike.

Stem Cells and Cell Therapy

Stem Cells and Cell Therapy
Author: Mohamed Al-Rubeai,Mariam Naciri
Publsiher: Springer Science & Business Media
Total Pages: 189
Release: 2013-10-01
ISBN 10: 9400771967
ISBN 13: 9789400771963
Language: EN, FR, DE, ES & NL

Stem Cells and Cell Therapy Book Review:

With the discovery of stem cells capable of multiplying indefinitely in culture and differentiating into many other cell types in appropriate conditions, new hopes were born in repair and replacement of damaged cells and tissues. The features of stem cells may provide treatment for some incurable diseases with some therapies are already in clinics, particularly those from adult stem cells. Some treatments will require large number of cells and may also require multiple doses, generating a growing demand for generating and processing large numbers of cells to meet the need of clinical applications. With this in mind, our aim is to provide a book on the subject of stem cells and cell therapy for researchers and students of cell biotechnology, bioengineering and bioproduction. This book is exceptional as it teaches researchers stem cells and cell therapy in that it covers the concepts and backgrounds necessary so that readers get a good understanding of the production of stem cells. The book covers three topics: The basics of stem cells and cell therapy, the use of stem cells for the treatment of human diseases, and stem cell processing. It includes chapters on neural and vascular stem vascular stem cell therapy, expansion engineering of embryonic stem cells, stem cell based production of blood cells and separation technologies for stem cells and cell therapy products. It is an informed and informative presentation of what modern research, science and engineering have learned about stem cells and their production and therapies. Addressing both the medical and production issues, this book is an invaluable contribution to having an academic and industrial understanding with respect to R&D and manufacturing of clinical grade stem cells.

Novel Concepts in iPSC Disease Modeling

Novel Concepts in iPSC Disease Modeling
Author: Alexander Birbrair
Publsiher: Academic Press
Total Pages: 336
Release: 2022-01-25
ISBN 10: 0128238836
ISBN 13: 9780128238837
Language: EN, FR, DE, ES & NL

Novel Concepts in iPSC Disease Modeling Book Review:

The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. iPSCs - Novel Concepts, Volume 15 addresses how important induced pluripotent stems cells are and how can they can help treat certain diseases. Somatic cells can be reprogrammed into induced pluripotent stem cells by the expression of specific transcription factors. These cells have been transforming biomedical research over the last 15 years. This volume will address the advances in research of how induced pluripotent stem cells are being used for treatment of different disorders, such as liver disease, type-1 diabetes, Parkinson’s disease, macular degeneration of the retina and much more. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of stem cell biology and function, regenerative medicine and therapeutics Covers spinal cord injuries, type-1 diabetes, liver disease, Parkinson’s disease, graft vs. host disease, and much more Contributed by world-renown experts in the field

Update on Mesenchymal and Induced Pluripotent Stem Cells

Update on Mesenchymal and Induced Pluripotent Stem Cells
Author: Khalid Ahmed Al-Anazi
Publsiher: BoD – Books on Demand
Total Pages: 148
Release: 2020-04-22
ISBN 10: 1789238072
ISBN 13: 9781789238075
Language: EN, FR, DE, ES & NL

Update on Mesenchymal and Induced Pluripotent Stem Cells Book Review:

This book represents an updated overview on selected topics related to mesenchymal stem cells as well as induced pluripotent stem cells. The book is divided into three main sections that cover several topics including: sources of both stem cell types, their preparation and general properties, as well as their therapeutic indications and clinical utilization with particular attention given to their use in infectious diseases, osteoarthritis, as well as immunological disorders.