Molecular Biology of the Cell

Molecular Biology of the Cell
Author: Bruce Alberts
Publsiher: Unknown
Total Pages: 329
Release: 2004
ISBN 10: 9780815332183
ISBN 13: 0815332181
Language: EN, FR, DE, ES & NL

Molecular Biology of the Cell Book Review:

The Innate Immune System

The Innate Immune System
Author: Tom Monie
Publsiher: Academic Press
Total Pages: 228
Release: 2017-02-16
ISBN 10: 0081007582
ISBN 13: 9780081007587
Language: EN, FR, DE, ES & NL

The Innate Immune System Book Review:

The Innate Immune System: A Compositional and Functional Perspective focuses on the components and functionality of the innate immune system, detailing how they work in their own right, and then progressing to cover their relevance to disease and how they interface with the adaptive response. Despite the growing appreciation of the importance of the innate immune system, many classical immunology books still focus predominantly on the adaptive immune response. Not only is this unbalanced, but it fails to reflect the growing synergy between the activation and function of the innate response and the final nature of adaptive response. This book fills the gap in knowledge that is needed to fully understand and appreciate the topic. Provides a clear, but simple picture of the main principle of innate immunity and the interlink with adaptive responses Fulfills an unmet need in the area of innate immunity Gives a constructive and progressive approach to introducing and explaining the key players in the innate immune response Introduces and explains the key players in the innate immune response with a constructive and progressive approach Presents the components of the innate response and shows how these interrelated areas connect with one another from a functional perspective Enables the reader to gradually increase their level of understanding and knowledge without the risk of becoming confused, thereby ensuring they fully comprehend the integrated signaling pathways

Janeway s Immunobiology

Janeway s Immunobiology
Author: Murphy, Kenneth M.,Weaver, Casey
Publsiher: W.W. Norton & Company
Total Pages: 904
Release: 2016-03-22
ISBN 10: 0815345518
ISBN 13: 9780815345510
Language: EN, FR, DE, ES & NL

Janeway s Immunobiology Book Review:

Explore the premier text for immunology at the advanced undergraduate, graduate, and medical school levels. Beginning students appreciate the bookÕs clear writing and informative illustrations, while advanced students and working immunologists value its comprehensive scope and depth. This edition is thoroughly revised and up to date with significant developments in the field, especially on the topic of innate immunity.

Innate Immunity

Innate Immunity
Author: Yves Carton
Publsiher: Iste Press - Elsevier
Total Pages: 324
Release: 2019-11-15
ISBN 10: 1785483080
ISBN 13: 9781785483080
Language: EN, FR, DE, ES & NL

Innate Immunity Book Review:

Innate immunity is a new branch of immunology, confirmed by three Nobel Prize winners in 2011. It is the first line of defense against pathogens and is in a way the preliminary step of adaptive immunity which occurs later, and only present in vertebrates. This book examines the way in which innate immunity was discovered in invertebrates. As a starting point, it looks at the work of Louis Pasteur on silkworm disease and the findings of Ilya Metchnikov, discoverer of phagocytosis. It also investigates André Paillot, who in 1920 demonstrated the existence of humoral immunity in insects, unrelated to the type of immunity that was initially thought to be present in all vertebrates. Finally, Innate Immunity shows how the group directed by Jules Hoffmann found strong similarities between the innate immunity response of insects and mammals. The discovery of a receptor protein in Drosophila, which is also found in humans, was what led to Jules Hoffmann being awarded the Nobel Prize in 2011. Presents the transformations experienced by the domains of innate immunity Shows the lineage of these results Bridges the gap between innate immunity of invertebrates and that of vertebrates

Innate Immunity Resistance and Disease Promoting Principles

Innate Immunity  Resistance and Disease Promoting Principles
Author: G. Hartmann,H. Wagner
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 138
Release: 2013-06-05
ISBN 10: 3318023485
ISBN 13: 9783318023480
Language: EN, FR, DE, ES & NL

Innate Immunity Resistance and Disease Promoting Principles Book Review:

Our understanding of the complex innate immune response is increasing rapidly. Its role in the protection against viral or bacterial pathogens is essential for the survival of an organism. However, it is equally important to avoid unregulated inflammation because innate immune responses can cause or promote chronic autoinflammatory diseases such as gout, atherosclerosis, type 2 diabetes or certain aspects of the metabolic syndrome. In this book leading international experts in the field of innate immunity share their findings, define the ‚state of the art‘ in this field and evaluate how insight into the molecular basis of these diseases could help in the design of new therapies. A tremendous amount of work on the innate immune response has been done over the last fifteen years, culminating in the 2011 Nobel Prize in Physiology/Medicine awarded for the discoveries of Toll genes in immunity in flies, membrane-bound Toll-like receptors in mammals, and dendritic cells as initiators of adaptive immunity.

Nucleic Acids in Innate Immunity

Nucleic Acids in Innate Immunity
Author: Ken J. Ishii,Shizuo Akira
Publsiher: CRC Press
Total Pages: 304
Release: 2008-05-22
ISBN 10: 9781420068269
ISBN 13: 1420068261
Language: EN, FR, DE, ES & NL

Nucleic Acids in Innate Immunity Book Review:

Until recently, innate immunity was regarded as a relatively nonspecific system designed to engulf and destroy pathogens. However, new studies show that the innate immune system is highly developed in its ability to discriminate between self and foreign entities. Understanding this mechanism can lead to therapeutic strategies based on manipulation of this previously unexploited branch of the immune system. Drawing on the research of leading experts, Nucleic Acids in Innate Immunity provides insight in this new area of immunology. The book begins by explaining the roles of nucleic acids in immunity, describing the mechanism of discrimination based on pattern-recognition receptors (PRRs), including Toll-like receptors (TLRs), Nod-like receptors (NLR), and RIG-I-like receptors (RLR). Chapters discuss how these PRRs recognize and respond to pathogen-associated molecular patterns (PAMPs) by activating specific signaling pathways. The second section focuses on the therapeutic applications of immunomodulatory DNA by manipulating released pathogenic nucleic acids as immune system stimulants. The book introduces novel therapeutics developed to prevent or treat infectious diseases, allergic disorders, and cancer, as well as clearing unnecessary or abnormal host molecules. The final section addresses how the immune system discriminates self and non-self RNA. Recent findings that host (self) nucleic acids are not inert in the immune system beg the question of exactly what elements within DNA or RNA are recognized by the innate immune system. Contributions review recent advances to understand innate immune recognition of nucleic acids and describe the resulting immune modulation. Providing a comprehensive review of nucleic acid recognition and regulation by the innate immune system, this seminal work reveals new directions for future research in immune modulation.

The Innate Immune Response to Noninfectious Stressors

The Innate Immune Response to Noninfectious Stressors
Author: Massimo Amadori
Publsiher: Academic Press
Total Pages: 276
Release: 2016-02-23
ISBN 10: 0128019743
ISBN 13: 9780128019740
Language: EN, FR, DE, ES & NL

The Innate Immune Response to Noninfectious Stressors Book Review:

The Innate Immune Response to Non-infectious Stressors: Human and Animal Models highlights fundamental mechanisms of stress response and important findings on how the immune system is affected, and in turn affects such a response. In addition, this book covers the crucial link between stress response and energy metabolism, prompts a re-appraisal of some crucial issues, and helps to define research priorities in this fascinating, somehow elusive field of investigation. Provides insights into the fundamental homeostatic processes vis-à-vis stressors to help in investigation Illustrates the depicted tenets and how to offset them against established models of response to physical and psychotic stressors in both animals and humans Covers the crucial issue of the immune response to endocrine disruptors Includes immunological parameters as reporter system of environmental adaptation Provides many illustrative examples to foster reader understanding

Innate Immunity

Innate Immunity
Author: Jonathan Ewbank,Eric Vivier
Publsiher: Springer Science & Business Media
Total Pages: 458
Release: 2008
ISBN 10: 1588297462
ISBN 13: 9781588297464
Language: EN, FR, DE, ES & NL

Innate Immunity Book Review:

Immunologists today are interested in all of the diverse cell-types involved in host defense and have a deeper appreciation of the importance of innate immune mechanisms as a first line of protection against pathogens. This volume thus discusses the isolation and functional characterization of cells involved in innate immunity in mouse and man, including mast cells and eosinophils. Other focuses include natural killer cells, methods in statistics, in vivo imaging, genome engineering, and mutagenesis and culture that are adapted to the study of innate immunity in these hosts. These are complemented with a series of chapters dealing with alternative models: plants, worms, mosquitoes, flies, and fish. Together, these approaches and models are being used to dissect the complex interplay between hosts and pathogens and contribute to developing strategies to help fight infection. With chapters written by experts on the cutting-edge of this technology, Innate Immunity is an essential reference for immunologists, histologists, geneticists, and molecular biologists.

Innate Immunity

Innate Immunity
Author: Yves Carton
Publsiher: Iste Press - Elsevier
Total Pages: 324
Release: 2019-11-15
ISBN 10: 1785483080
ISBN 13: 9781785483080
Language: EN, FR, DE, ES & NL

Innate Immunity Book Review:

Innate immunity is a new branch of immunology, confirmed by three Nobel Prize winners in 2011. It is the first line of defense against pathogens and is in a way the preliminary step of adaptive immunity which occurs later, and only present in vertebrates. This book examines the way in which innate immunity was discovered in invertebrates. As a starting point, it looks at the work of Louis Pasteur on silkworm disease and the findings of Ilya Metchnikov, discoverer of phagocytosis. It also investigates André Paillot, who in 1920 demonstrated the existence of humoral immunity in insects, unrelated to the type of immunity that was initially thought to be present in all vertebrates. Finally, Innate Immunity shows how the group directed by Jules Hoffmann found strong similarities between the innate immunity response of insects and mammals. The discovery of a receptor protein in Drosophila, which is also found in humans, was what led to Jules Hoffmann being awarded the Nobel Prize in 2011. Presents the transformations experienced by the domains of innate immunity Shows the lineage of these results Bridges the gap between innate immunity of invertebrates and that of vertebrates

The Biology and Pathology of Innate Immunity Mechanisms

The Biology and Pathology of Innate Immunity Mechanisms
Author: Yona Keisari,Itzhak Ofek
Publsiher: Springer Science & Business Media
Total Pages: 330
Release: 2006-07-06
ISBN 10: 030646831X
ISBN 13: 9780306468315
Language: EN, FR, DE, ES & NL

The Biology and Pathology of Innate Immunity Mechanisms Book Review:

In recent years increased scientific attention has been given to immediate defense mechanisms based on non-clonal recognition of microbial components. These mechanisms constitute the innate immunity arm of the body s defense. Identification of pathogens by these mechanisms involves primarily receptors recognizing sugar moieties of various microorganisms. Innate immunity based mechanisms are essential for the existence of multicellular organisms. They are evolutionarily conserved and designed to provide immediate protection against microbial pathogens to eradicate infection. Activation of innate immunity is crucial for transition to specific immunity and for its orientation, and to assist the specific immune response in the recognition of pathogens and their destruction. Innate immunity is regularly involved in the arrest of bacterial, mycotic, viral and parasitic infections, giving the specific immune response time to become effective. It becomes critically essential in immunocompromised patients who fail to mount specific immune responses due to congenital or acquired immunodeficiencies as a result of chemotherapy, dialysis, immunosuppressive drugs, or HIV infection. The Innate Immunity arsenal constitutes polymorphonuclear and mononuclear phagocytes, mast cells, the complement system, Natural Killer cells, antimicrobial peptides, and presumably a subset of T lymphocytes with TCRl receptors.

Experimental Approaches For The Investigation Of Innate Immunity The Human Innate Immunity Handbook

Experimental Approaches For The Investigation Of Innate Immunity  The Human Innate Immunity Handbook
Author: Richard Bucala,Ruth R Montgomery
Publsiher: World Scientific
Total Pages: 180
Release: 2016-01-15
ISBN 10: 9814678740
ISBN 13: 9789814678742
Language: EN, FR, DE, ES & NL

Experimental Approaches For The Investigation Of Innate Immunity The Human Innate Immunity Handbook Book Review:

The recent explosion of information in innate immune pathways for recognition, effect or responses, and genetic regulation has given impetus to investigations into analogous pathways in the human immune response, which in turn has produced attendant insights into both normal physiology and immunopathology. This volume presents a compendium of methods and protocols for the investigation of human innate immunity with application to the study of normal immune function, immunosenescence, autoimmunity and infectious diseases. Among the topics covered are quantitative flow cytometry for Toll-like receptor expression and function; multidimensional single cell mass cytometry (CyTOF) in complex immune interactions and tumor immunity; imaging techniques such as Imagestream high resolution microscopy coupled to flow cytometry, immune cell infiltration of organotypic, biomimetic organs; high-throughput single cell secretion profiling; multiplexed transcriptomic profiling; microsatellite and microRNA methodologies, RNA interference; and the latest bioinformatics and biostatistical methodologies, including in-depth statistical modeling, genetic mapping, and systems approaches.

Innate Immunity of Plants Animals and Humans

Innate Immunity of Plants  Animals and Humans
Author: Holger Heine
Publsiher: Springer Science & Business Media
Total Pages: 241
Release: 2007-12-07
ISBN 10: 3540739300
ISBN 13: 9783540739302
Language: EN, FR, DE, ES & NL

Innate Immunity of Plants Animals and Humans Book Review:

This book has been cunningly designed to provide an overview of our current knowledge about the innate immune systems of these three types of organisms. It not only covers the innate immune mechanisms and responses of such diverse organisms as plants, Cnidaria, Drosophila, urochordates and zebrafish, but also the major receptor systems in mammalians and humans. It delves too into the central defense mechanisms, antimicrobial peptides and the complement system.

Innate Immune System of Skin and Oral Mucosa

Innate Immune System of Skin and Oral Mucosa
Author: Nava Dayan,Philip W. Wertz
Publsiher: John Wiley & Sons
Total Pages: 368
Release: 2011-08-23
ISBN 10: 0470437774
ISBN 13: 9780470437773
Language: EN, FR, DE, ES & NL

Innate Immune System of Skin and Oral Mucosa Book Review:

An in-depth look at cutting-edge research on the body's innate immune system Innate immunity is the body's first line of protection against potential microbial, viral, and environmental attacks, and the skin and oral mucosa are two of the most powerful barriers that which we rely on to stay well. The definitive book on the subject, Innate Immune System of Skin and Oral Mucosa: Properties and Impact in Pharmaceutics, Cosmetics, and Personal Care Products provides a comprehensive overview of these systems, including coverage of antimicrobial peptides and lipids and microbial challenges and stressors that can influence innate immunity. Designed to help experts and newcomers alike in fields like dermatology, oral pathology, cosmetics, personal care, and pharmaceuticals, the book is filled with suggestions to assist research and development. Looking at the many challenges facing the innate immune system, including the impact of topically applied skin products and medications, Innate Immune System of Skin and Oral Mucosa paves the way for next generation treatment avenues, preventative approaches, and drug development.

Immunomodulation of Innate Immune Cells

Immunomodulation of Innate Immune Cells
Author: Catarina R. Almeida,Barbara Bottazzi,Kate E. Lawlor,Dominic De Nardo
Publsiher: Frontiers Media SA
Total Pages: 329
Release: 2020-03-23
ISBN 10: 2889635740
ISBN 13: 9782889635740
Language: EN, FR, DE, ES & NL

Immunomodulation of Innate Immune Cells Book Review:

Innate Immunity and Inflammation

Innate Immunity and Inflammation
Author: Ruslan Medzhitov
Publsiher: Unknown
Total Pages: 240
Release: 2014-10-01
ISBN 10: 9781621820291
ISBN 13: 1621820297
Language: EN, FR, DE, ES & NL

Innate Immunity and Inflammation Book Review:

The innate immune system is rapidly activated in response to infection and injury. It is a generic rather than pathogen-specific response that recruits immune cells, promotes inflammation, and mobilizes the adaptive immune system. Excessive or chronic inflammation may cause tissue damage, so a careful balance is required to restore homeostasis. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology reviews the cellular and molecular mechanisms involved in innate immunity and all types of inflammation. The contributors examine the cell types that make up the innate immune system, their use of pattern recognition receptors (e.g., Toll-like receptors) to identify pathogens and damaged tissues, and how they trigger signaling pathways that culminate in inflammation, pathogen destruction, and tissue repair. The numerous chemical signals and factors involved in innate immunity and inflammation are described, as are those that keep inflammation in check. The authors also discuss the diseases that can result when these processes go awry, such as rheumatoid arthritis and cancer. This volume is therefore a valuable reference for all immunologists, cell biologists, and medical scientists wishing to understand these protective processes and their implications for human health and disease.

Innate Immunity in Aquatic Vertebrates

Innate Immunity in Aquatic Vertebrates
Author: Leon Grayfer,Stephanie DeWitte-Orr,Eva-Stina Isabella Edholm
Publsiher: Frontiers Media SA
Total Pages: 329
Release: 2020-01-17
ISBN 10: 2889634272
ISBN 13: 9782889634279
Language: EN, FR, DE, ES & NL

Innate Immunity in Aquatic Vertebrates Book Review:

Antibody Fc

Antibody Fc
Author: Margaret Ackerman,Falk Nimmerjahn
Publsiher: Academic Press
Total Pages: 358
Release: 2013-08-06
ISBN 10: 0123948185
ISBN 13: 9780123948182
Language: EN, FR, DE, ES & NL

Antibody Fc Book Review:

Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology. Antibodies represent the correlate of protection for numerous vaccines and are the most rapidly growing class of drugs, with applications ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for antigen recognition, and can provide protection by blocking the function of their target antigen. However, recent developments in our understanding of the protection mediated by antibodies have highlighted the critical nature of the antibody constant, or Fc domain, in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, providing specificity to a wide range of innate effector cells. In addition, they provide a feedback loop to regulate the character of the immune response via interactions with B cells and antigen-presenting cells. Clarifies the different mechanisms of IgG activity at the level of the different model systems used, including human genetic, mouse, and in vitro Covers the role of antibodies in cancer, infectious disease, and autoimmunity and in the setting of monoclonal antibody therapy as well as naturally raised antibodies Color illustrations enhance explanations of the immune system

Concepts of Biology

Concepts of Biology
Author: Samantha Fowler,Rebecca Roush,James Wise
Publsiher: Unknown
Total Pages: 618
Release: 2018-01-07
ISBN 10: 9789888407453
ISBN 13: 9888407457
Language: EN, FR, DE, ES & NL

Concepts of Biology Book Review:

Concepts of Biology is designed for the single-semester introduction to biology course for non-science majors, which for many students is their only college-level science course. As such, this course represents an important opportunity for students to develop the necessary knowledge, tools, and skills to make informed decisions as they continue with their lives. Rather than being mired down with facts and vocabulary, the typical non-science major student needs information presented in a way that is easy to read and understand. Even more importantly, the content should be meaningful. Students do much better when they understand why biology is relevant to their everyday lives. For these reasons, Concepts of Biology is grounded on an evolutionary basis and includes exciting features that highlight careers in the biological sciences and everyday applications of the concepts at hand.We also strive to show the interconnectedness of topics within this extremely broad discipline. In order to meet the needs of today's instructors and students, we maintain the overall organization and coverage found in most syllabi for this course. A strength of Concepts of Biology is that instructors can customize the book, adapting it to the approach that works best in their classroom. Concepts of Biology also includes an innovative art program that incorporates critical thinking and clicker questions to help students understand--and apply--key concepts.

STATs and IRFs in Innate Immunity From Transcriptional Regulators to Therapeutic Targets

STATs and IRFs in Innate Immunity  From Transcriptional Regulators to Therapeutic Targets
Author: Chien-Kuo Lee,Hans A. R. Bluyssen
Publsiher: Frontiers Media SA
Total Pages: 329
Release: 2019-10-21
ISBN 10: 2889631257
ISBN 13: 9782889631254
Language: EN, FR, DE, ES & NL

STATs and IRFs in Innate Immunity From Transcriptional Regulators to Therapeutic Targets Book Review:

Innate Immune Cell Determinants of T Cell Immunity From Basic Mechanisms to Clinical Implications

Innate Immune Cell Determinants of T Cell Immunity  From Basic Mechanisms to Clinical Implications
Author: Elisabetta Padovan,Stefan F. Martin
Publsiher: Frontiers Media SA
Total Pages: 329
Release: 2016-07-14
ISBN 10: 288919907X
ISBN 13: 9782889199075
Language: EN, FR, DE, ES & NL

Innate Immune Cell Determinants of T Cell Immunity From Basic Mechanisms to Clinical Implications Book Review:

Long-lasting T cell immunity is delivered by an array of individual T lymphocytes expressing clonally distributed and highly specific antigen receptors recognizing an almost infinite number of antigens that might enter in contact with the host. Following antigen-specific priming in lymphnodes, naïve CD4 and CD8 T lymphocytes proliferate generating clones of effector cells that migrate to peripheral tissues and deliver unique antigen-specific effector functions. Moreover, a proportion of these effector lymphocytes survive as memory T cells that can be rapidly mobilized upon new exposure to the same antigen, even years after their primary induction. Innate immune cells play crucial roles in the induction and maintenance of this efficient protection system. Following the seminal discovery of Steinman and Cohen in 1974 describing a rare cell type capable of initiating antigen-specific responses in lymphnodes, Dendritic Cells (DC) have taken up the stage for several decades as professional Antigen Presenting Cells (APC). Although DC possess all attributes to prime naïve T lymphocytes, other immune cell subsets become crucial accessory cells during secondary and even primary activation. For instance, Monocytes (Mo) are rapidly recruited to inflammatory sites and have recently been recognized as capable of shaping T cell immunity, either directly through Ag presentation, or indirectly through the secretion of soluble factors. In addition, upon sensing of T cell-derived cytokines, Mo differentiate into functionally different APC types that further impact on the quality and persistence of memory T cell responses in peripheral tissues. Other innate immune cells, including Myeloid Derived Suppressor Cells, Granulocytes and iNKT lymphocytes, are known to modulate T cell activation by interacting with and modifying the function of professional APC. Notably, innate immune cell determinants also account for the tissue-specific regulation of T cell immunity. Hence, the newly discovered family of Innate Lymphoid Cells, has been recognized to shape CD4+ T cell responses at mucosal surfaces. Although the actions of innate immune cells fulfills the need of initiating and maintaining protective T cell responses, the excessive presence or activity of individual determinants may be detrimental to the host, because it could promote tissue destruction as in autoimmunity and allergy, or conversely, prevent the induction of immune responses against malignant tissues, and even modulate the response to therapeutic agents. Thus, understanding how defined innate immune cell subsets control T cell immunity is of fundamental relevance to understand human health, and of practical relevance for preventing and curing human diseases. In this research topic, we intend to provide an excellent platform for the collection of manuscripts addressing in depth how diverse innate immune cell subsets impact on T cell responses through molecularly defined pathways and evaluating the rational translation of basic research into clinical applications.