Infections in Systemic Autoimmune Diseases Risk Factors and Management Volume 16

Infections in Systemic Autoimmune Diseases  Risk Factors and Management  Volume 16
Author: James Galloway
Publsiher: Handbook of Systemic Autoimmun
Total Pages: 226
Release: 2020-03-16
ISBN 10: 044464217X
ISBN 13: 9780444642172
Language: EN, FR, DE, ES & NL

Infections in Systemic Autoimmune Diseases Risk Factors and Management Volume 16 Book Review:

Infections in Systemic Autoimmune Diseases: Risk Factors and Management, Volume Sixteen describes the state-of-the-art of the risk factors and management treating the most common systemic autoimmune diseases (SADS). This updated volume consists of an introductory chapter that provides a brief overview of what different types of infectious diseases exist, followed by eight chapters detailing risk factors, guidelines and recommendations per different disease and bacterial infections. International in scope, the list of more than 20 contributors from Europa and America reads like a who's who of clinical researchers in the field.

Idiotypes in Medicine Autoimmunity Infection and Cancer

Idiotypes in Medicine  Autoimmunity  Infection and Cancer
Author: R.C. Kennedy,S. Ferrone,Yehuda Shoenfeld
Publsiher: Elsevier
Total Pages: 540
Release: 1997-11-19
ISBN 10: 9780080534435
ISBN 13: 0080534430
Language: EN, FR, DE, ES & NL

Idiotypes in Medicine Autoimmunity Infection and Cancer Book Review:

This is the most comprehensive review of the idiotypic network available. All the current knowledge of idiotypes of the various antibodies is incorporated in this volume. The pathogenic role of idiotypes in autoimmunity and cancer is reviewed in depth. The therapeutic part focusses on harnessing anti-idiotypes for treating autoimmunological disorders, and on the employment of idiotypes for vaccines in cancer and infectious diseases, as well as explaining the manipulation of the idiotypic network in autoimmunity and cancer idiotypes and vaccines.

The Saint Chopra Guide to Inpatient Medicine

The Saint Chopra Guide to Inpatient Medicine
Author: Sanjay Saint,Vineet Chopra
Publsiher: Oxford University Press
Total Pages: 656
Release: 2018-11-09
ISBN 10: 0190862823
ISBN 13: 9780190862824
Language: EN, FR, DE, ES & NL

The Saint Chopra Guide to Inpatient Medicine Book Review:

THE DEFINITIVE GUIDE TO INPATIENT MEDICINE, UPDATED AND EXPANDED FOR A NEW GENERATION OF STUDENTS AND PRACTITIONERS A long-awaited update to the acclaimed Saint-Frances Guides, the Saint-Chopra Guide to Inpatient Medicine is the definitive practical manual for learning and practicing inpatient medicine. Its end-to-end coverage of the specialty focuses on both commonly encountered problems and best practices for navigating them, all in a portable and user-friendly format. Composed of lists, flowcharts, and "hot key" clinical insights based on the authors' decades of experience, the Saint-Chopra Guide ushers clinicians through common clinical scenarios from admission to differential diagnosis and clinical plan. It will be an invaluable addition -- and safety net -- to the repertoire of trainees, clinicians, and practicing hospitalists at any stage of their career.

Therapeutic Implications for Pregnant Women with Systemic Autoimmune Diseases and their Children

Therapeutic Implications for Pregnant Women with Systemic Autoimmune Diseases and their Children
Author: Cecilia Beatrice Chighizola,Maria Gerosa,Guilherme Ramires De Jesús,Tadej Avcin
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2022-01-13
ISBN 10: 2889740730
ISBN 13: 9782889740734
Language: EN, FR, DE, ES & NL

Therapeutic Implications for Pregnant Women with Systemic Autoimmune Diseases and their Children Book Review:

Antiphospholipid Syndrome in Systemic Autoimmune Diseases

Antiphospholipid Syndrome in Systemic Autoimmune Diseases
Author: R. Cervera,Ricard Cervera
Publsiher: Elsevier
Total Pages: 266
Release: 2009-04-01
ISBN 10: 9780080932347
ISBN 13: 0080932347
Language: EN, FR, DE, ES & NL

Antiphospholipid Syndrome in Systemic Autoimmune Diseases Book Review:

Antiphospholipid syndrome is an autoimmune disease that causes abnormal blood clots. It is now recognized as a major cause of common conditions, including stroke, heart attack, miscarriage, epilepsy and memory loss and as such is gaining recognition in all branches of medicine, from obstetrics to cardiology, from psychiatry to orthopedics. This book provides an overview of our current understanding of this major disease. It includes the latest information on the new pathogenetic mechanisms involved as well as clinical manifestations in both “the thrombotic and “non-thrombotic manifestations of this important disease. * Comprehensive review of this major disease * Includes information on treatment options available

Antiphospholipid Syndrome in Systemic Autoimmune Diseases

Antiphospholipid Syndrome in Systemic Autoimmune Diseases
Author: Ricard Cervera,Gerard Espinosa,Munther Khamashta
Publsiher: Elsevier
Total Pages: 326
Release: 2016-06-18
ISBN 10: 0444636560
ISBN 13: 9780444636560
Language: EN, FR, DE, ES & NL

Antiphospholipid Syndrome in Systemic Autoimmune Diseases Book Review:

Antiphospholipid Syndrome in Systemic Autoimmune Diseases, Second Edition provides an overview of our current understanding of this major disease. It includes the latest information on the new pathogenetic mechanisms involved, along with clinical manifestations in both the thrombotic and non-thrombotic manifestations of this important disease. Antiphospholipid syndrome is an autoimmune disease that causes abnormal blood clots. It is now recognized as a major cause of common conditions, including stroke, heart attack, miscarriage, epilepsy, and memory loss, and as such is gaining recognition in all branches of medicine, from obstetrics to cardiology, and from psychiatry to orthopedics. Brings the reader up-to-date and allows easy access to individual topics in one place Written by a respected panel of distinguished physicians/scientists actively involved in the field of Antiphospholipid Syndrome Includes box summaries at the end of each chapter that highlight important topics Gives up-to-date, basic knowledge and a modern approach to diagnosis and therapy Provides a comprehensive review of this major disease Includes information on treatment options available

Systemic Autoimmunity

Systemic Autoimmunity
Author: P. E. Bigazzi
Publsiher: CRC Press
Total Pages: 320
Release: 1991-08-30
ISBN 10: 9780824785505
ISBN 13: 0824785509
Language: EN, FR, DE, ES & NL

Systemic Autoimmunity Book Review:

Surveys the biotechnologically influenced advances in the understanding of systemic autoimmune disorders, highlighting recent research using cell biology and biochemistry, the cloning of immune cells, recombinant DNA, and molecular genetics. Among the topics are the role of complement in inflammatio

The Autoimmune Brain

The Autoimmune Brain
Author: David S. Younger
Publsiher: Rowman & Littlefield Publishers
Total Pages: 288
Release: 2019-11-10
ISBN 10: 1538117711
ISBN 13: 9781538117712
Language: EN, FR, DE, ES & NL

The Autoimmune Brain Book Review:

There are millions of people who experience issues related to brain health--depression, attention issues, anxiety, forgetfulness, fatigue, and even chronic pain--yet can’t figure out what’s causing their problems and can’t find any relief. They may have seen a myriad of doctors, many of whom do not take their complaints seriously, or worse, turn to the easy, often inappropriate fix of antidepressants or antianxiety medications. Traditional medications, supplements, or other therapies haven’t worked. No matter what their age--from children to teens or seniors--people and their loved ones are frustrated, scared, and confused by their continued poor health. Countless others display severe psychiatric symptoms that seem to come out of nowhere, ranging from tics, obsessive-compulsive behaviors and anxiety, to depression, bipolar-like mood swings, and even borderline personality disorder and suicidal ideas. . Sometimes, the people affected are the only ones that notices a change to the way they think or feel, and they suffer in silence. Or, they reach out to try to get help, and are all too frequently misdiagnosed. Now, Dr. David Younger, a world-renowned physician, provides relief to these patients and their families. His diagnostic techniques and treatment protocols will help readers identify the true cause of their symptoms and put them on a clear path to healing so they no longer feel unbalanced, out of control, forgetful, and exhausted. THE AUTOIMMUNE BRAIN connects common brain health symptoms to the changes in the immune system, and particularly bacterial, viral, and parasitic infections. In this book, Dr. Younger explains his groundbreaking research and adds a new component: how traumatic stress (whether physical or emotional) and genetics affects this same triad as inextricable factors in initiating disease and brain health symptoms. In fact, a change in personality, behavior, coping style, and one’s emotional state may be the first clue that there is a health problem brewing somewhere else in the body. Readers will find new answers to troubling conditions, including: Alzheimer’s disease Anxiety Arthritis Autism Autonomic disturbances Bacterial and viral infections Bipolar Disorder Cancer Celiac disease and gluten intolerances Chronic Fatigue Syndrome (now referred to as Systemic Exertion Intolerance Disease) Chronic Pain Dementia Depression Endocrine Disorders Immune modulatory therapy using IVIg Lyme disease and co-infections Mast cell activation syndrome Medical cannabis Obsessive Compulsive Disorder Orthostatic hypotension Peripheral Neuropathy Porphyria Post-Traumatic Stress Disorder Postural orthostatic tachycardia

Progress in Systemic Lupus Erythematosus Research

Progress in Systemic Lupus Erythematosus Research
Author: Tomas I. Seward
Publsiher: Nova Publishers
Total Pages: 264
Release: 2007
ISBN 10: 9781600218613
ISBN 13: 160021861X
Language: EN, FR, DE, ES & NL

Progress in Systemic Lupus Erythematosus Research Book Review:

This new book is devoted to leading-edge research developments in lupus which is a condition of chronic inflammation caused by an autoimmune disease. Autoimmune diseases are illnesses that occur when the body's tissues are attacked by its own immune system. The immune system is a complex system within the body that is designed to fight infectious agents, for example, bacteria, and other foreign invaders. One of the mechanisms that the immune system uses to fight infections is the production of antibodies. Patients with lupus produce abnormal antibodies in their blood that target tissues within their own body rather than foreign infectious agents. Because the antibodies and accompanying cells of inflammation can involve tissues anywhere in the body, lupus has the potential to affect a variety of areas of the body. Sometimes lupus can cause disease of the skin, heart, lungs, kidneys, joints, and/or nervous system. When only the skin is involved, the condition is called discoid lupus. When internal organs are involved, the condition is called systemic lupus erythematosus (SLE).

Vaccines and Autoimmunity

Vaccines and Autoimmunity
Author: Yehuda Shoenfeld,Nancy Agmon-Levin,Lucija Tomljenovic
Publsiher: John Wiley & Sons
Total Pages: 384
Release: 2015-07-07
ISBN 10: 1118663438
ISBN 13: 9781118663431
Language: EN, FR, DE, ES & NL

Vaccines and Autoimmunity Book Review:

In light of the discovery of Autoimmune Syndrome Induced by Adjuvants, or ASIA, Vaccines and Autoimmunity explores the role of adjuvants – specifically aluminum in different vaccines – and how they can induce diverse autoimmune clinical manifestations in genetically prone individuals. Vaccines and Autoimmunity is divided into three sections; the first contextualizes the role of adjuvants in the framework of autoimmunity, covering the mechanism of action of adjuvants, experimental models of adjuvant induced autoimmune diseases, infections as adjuvants, the Gulf War Syndrome, sick-building syndrome (SBS), safe vaccines, toll-like receptors, TLRS in vaccines, pesticides as adjuvants, oil as adjuvant, mercury, aluminum and autoimmunity. The following section reviews literature on vaccines that have induced autoimmune conditions such as MMR and HBV, among others. The final section covers diseases in which vaccines were known to be the solicitor – for instance, systemic lupus erythematosus – and whether it can be induced by vaccines for MMR, HBV, HCV, and others. Edited by leaders in the field, Vaccines and Autoimmunity is an invaluable resource for advanced students and researchers working in pathogenic and epidemiological studies.

Autoantibodies and Cytokines

Autoantibodies and Cytokines
Author: Wahid Ali Khan
Publsiher: Unknown
Total Pages: 216
Release: 2019-04-24
ISBN 10: 1789848520
ISBN 13: 9781789848526
Language: EN, FR, DE, ES & NL

Autoantibodies and Cytokines Book Review:

The mechanism of autoantibodies cannot be explained without the detail knowledge of cytokines and interferon. These active molecules of immunology are very much dependent on each other and their function cannot be completed without their interaction towards each other. Currently, this the most updated book on this subject that helps the readers/students to upgrade their knowledge by going through chapter by chapter. Contribution by the renounced authors across the globe makes this book really unique and consider as one of the most updated textbook on this subject. This book provides a comprehensive guide to the function and types of autoantibodies and cytokines in basic and clinical field.

Infections in Systemic Autoimmune Diseases

Infections in Systemic Autoimmune Diseases
Author: Anonim
Publsiher: Elsevier
Total Pages: 228
Release: 2020-03-08
ISBN 10: 0444642188
ISBN 13: 9780444642189
Language: EN, FR, DE, ES & NL

Infections in Systemic Autoimmune Diseases Book Review:

Infections in Systemic Autoimmune Diseases: Risk Factors and Management, Volume Sixteen describes the state-of-the-art of the risk factors and management treating the most common systemic autoimmune diseases (SADS). This updated volume consists of an introductory chapter that provides a brief overview of what different types of infectious diseases exist, followed by eight chapters detailing risk factors, guidelines and recommendations per different disease and bacterial infections. International in scope, the list of more than 20 contributors from Europa and America reads like a who’s who of clinical researchers in the field. Written by leading international clinical/surgical and scientific experts on Infection problems in systemic autoimmune diseases Provides a practical guide to the safer treatment of infections in patients with autoimmune diseases Includes a number of problems and recommendation that cannot be found in other books Designed as a ‘guide to clinical practice’ for management and risk interventions required by patients with SAD’s

Veterans and Agent Orange

Veterans and Agent Orange
Author: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice,Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Eleventh Biennial Update)
Publsiher: National Academies Press
Total Pages: 738
Release: 2019-01-20
ISBN 10: 0309477166
ISBN 13: 9780309477161
Language: EN, FR, DE, ES & NL

Veterans and Agent Orange Book Review:

From 1962 to 1971, the U.S. military sprayed herbicides over Vietnam to strip the thick jungle canopy that could conceal opposition forces, to destroy crops that those forces might depend on, and to clear tall grasses and bushes from the perimeters of US base camps and outlying fire-support bases. Mixtures of 2,4-dichlorophenoxyacetic acid (2,4-D), 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), picloram, and cacodylic acid made up the bulk of the herbicides sprayed. The main chemical mixture sprayed was Agent Orange, a 50:50 mixture of 2,4-D and 2,4,5-T. At the time of the spraying, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most toxic form of dioxin, was an unintended contaminant generated during the production of 2,4,5-T and so was present in Agent Orange and some other formulations sprayed in Vietnam. Because of complaints from returning Vietnam veterans about their own health and that of their children combined with emerging toxicologic evidence of adverse effects of phenoxy herbicides and TCDD, the National Academies of Sciences, Engineering, and Medicine was asked to perform a comprehensive evaluation of scientific and medical information regarding the health effects of exposure to Agent Orange, other herbicides used in Vietnam, and the various components of those herbicides, including TCDD. Updated evaluations were conducted every two years to review newly available literature and draw conclusions from the overall evidence. Veterans and Agent Orange: Update 11 (2018) examines peer-reviewed scientific reports concerning associations between various health outcomes and exposure to TCDD and other chemicals in the herbicides used in Vietnam that were published between September 30, 2014, and December 31, 2017, and integrates this information with the previously established evidence database.

The Dendritic Cell Response to Exogenous and Endogenous Danger Signals

The Dendritic Cell Response to Exogenous and Endogenous Danger Signals
Author: Paul Matthew Gallo
Publsiher: Unknown
Total Pages: 150
Release: 2017
ISBN 10: 1928374650XXX
ISBN 13: OCLC:1280138218
Language: EN, FR, DE, ES & NL

The Dendritic Cell Response to Exogenous and Endogenous Danger Signals Book Review:

Systemic lupus erythematosus (SLE) is complex autoimmune disease in which autoantibodies form against double stranded DNA (dsDNA) and nuclear antigens. Autoantigen immune complexes form, deposit in the vasculature, and cause multisystem organ damage. Both genetic and environmental factors contribute to the development of SLE. This thesis will explore three major themes found in the study of SLE: 1) Bacterial infection as an environmental trigger, 2) cytokine dysregulation in immune cells, and 3) the treatment of end organ damage in the form of lupus nephritis. Viral infections have long been associated with the development of systemic autoimmune disease, but the mechanisms by which chronic bacterial infections may promote autoimmunity remain unclear. In chapter three we show that a component of bacterial biofilms, the amyloid-like protein "curli", irreversibly forms fibers with bacterial or eukaryotic DNA during biofilm formation. This interaction accelerates amyloid polymerization and creates potent immunogenic complexes that activate immune cells, including dendritic cells, to produce cytokines such as type I interferons, which are pathogenic in SLE. When given systemically, curli/DNA composites trigger immune activation and production of autoantibodies in lupus-prone and wild type mice. We also found that infection with curli-producing bacteria triggered higher autoantibody titers in lupus-prone mice compared to curli-deficient bacteria. These data provide a mechanism by which the microbiome and biofilm-producing enteric infections may contribute to the progression of SLE and point to a potential molecular target for treatment of autoimmunity. Cytokine dysregulation is also common in SLE patients. Serum cytokines are often elevated during active disease, including type I IFNs and IL-10. In chapter four we demonstrate that Il10 is a type I IFN response gene and has increased basal expression in dendritic cells (DCs) derived from pre-disease lupus-prone Sle1,2,3 mice. We show that Sle1,2,3-derived DCs overproduce IL-10 in response to TLR ligands and that this is the result of autocrine signaling though the type I IFN receptor (IFNAR). These results suggest that dysregulation of cytokine signaling in the myeloid compartment may contribute to IL-10 dysregulation in SLE. Renal disease remains a major cause of morbidity and mortality in SLE. A number of mouse models of chronic kidney disease have implicated the EGFR-family receptors in the progression of renal fibrosis and dysfunction. In chapter five we show that renal expression of ErbB2 is increased in murine lupus. We therefore asked if EGFR-family inhibition could prevent murine lupus nephritis. To test this possibility we used lapatinib, an EGFR-ErbB2 dual kinase inhibitor, in an IFN-accelerated model of murine lupus. We found that lapatinib administration lowered autoantibody levels but worsened renal disease. Lapatinib failure to treat murine lupus nephritis despite lowered autoantibody levels suggests EGFR-family signaling is required for tissue repair in the acute phase of kidney injury. Together this thesis clearly demonstrates the complexity of systemic autoimmune disease - bringing us to the crossroads of immunity and tolerance. The combination of both environmental triggers (e.g. bacterial infection) and genetic susceptibility (e.g. intrinsic cytokine dysregulation) leads to end organ damage (e.g. lupus nephritis). Here we sought to explore each aspect of disease progression in the hopes to develop better interventions for systemic autoimmune disease.

Infection Related Immune Mediated Diseases and Microbiota

Infection Related Immune Mediated Diseases and Microbiota
Author: Kyung-Yil Lee,Hiromichi Hamada,Miika Kaleva Arvonen
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2020-06-16
ISBN 10: 2889637441
ISBN 13: 9782889637447
Language: EN, FR, DE, ES & NL

Infection Related Immune Mediated Diseases and Microbiota Book Review:

Immunology and Psychiatry

Immunology and Psychiatry
Author: Norbert Müller,Aye-Mu Myint,Markus J. Schwarz
Publsiher: Springer
Total Pages: 408
Release: 2015-04-20
ISBN 10: 331913602X
ISBN 13: 9783319136028
Language: EN, FR, DE, ES & NL

Immunology and Psychiatry Book Review:

Psychiatric disorders are one of the most dramatic burdens for humankind. The role of immune dysfunction in the pathophysiology of these disorders has emerged during the last years, because there has been tremendous progress in psychoneuroimmunological research. Many results are presented here by pioneers in the field. The book addresses various effects of the immune system on the pathophysiology and course of psychiatric disorders and highlights the possible future impact on treatment decisions of various psychiatric disorders, including schizophrenia and depression. The contributions cover the role of in utero immune challenges on the development of schizophrenia, the role of infections, and autoimmune diseases and mild immune activation in the development of depression and schizophrenia, the influence of immune responses in other disorders such as Tourette's, Alzheimer's, and OCD, the connections between mental and physical pain as well as between anti-inflammatory and antipsychotic drugs.​

The Autoimmune Diseases

The Autoimmune Diseases
Author: Noel R. Rose,Ian R. Mackay
Publsiher: Unknown
Total Pages: 895
Release: 1998
ISBN 10: 1928374650XXX
ISBN 13: UOM:39015045615823
Language: EN, FR, DE, ES & NL

The Autoimmune Diseases Book Review:

Since the First Edition of The Autoimmune Diseases was published in 1985, interest as well as knowledge about autoimmune diseases has greatly increased. This edition incorporates new material and combines the basic aspects of autoimmunity with discussion of specific autoimmune diseases in humans. It discusses the biological basis of disease at genetic, molecular, cellular, and epidemiologic levels. In addition to a comprehensive discussion of various autoimmune diseases and organ systems, the editors also cover the role of autoimmunity in cancer, AIDS, and aging. Key Features * Provides comprehensive discussions of all autoimmune diseases and organ systems * Offers "bench to bedside" coverage of autoimmunity for both clinicians and research scientists * Discusses the biological basis of disease at genetic, molecular, cellular, and epidemiologic levels * Examines the environmental determinants of autoimmune disease * Examines the association between autoimmunity and aging, cancer, and AIDS

Pediatrics in Systemic Autoimmune Diseases

Pediatrics in Systemic Autoimmune Diseases
Author: Rolando Cimaz,Thomas J.A. Lehman
Publsiher: Elsevier
Total Pages: 606
Release: 2016-06-08
ISBN 10: 0444635971
ISBN 13: 9780444635976
Language: EN, FR, DE, ES & NL

Pediatrics in Systemic Autoimmune Diseases Book Review:

Pediatrics in Systemic Autoimmune Diseases, Second Edition, provides a good starting point for physicians and scientists new to the field and for anyone looking for the most up-to-date summary of a particular disease. While many questions are answered, many more are raised for which we do not yet have the answers. The book provides inspiration to readers conducting their own research and helps to answer their questions. The care of children with systemic autoimmune diseases is moving forward at a rapid pace. The systemic autoimmune diseases of childhood have always represented a special problem for the physicians and scientists who care for the affected children and study their diseases. Some conditions, such as Kawasaki disease, are virtually unique to childhood, while systemic lupus erythematosus, progressive systemic sclerosis, and juvenile onset spondyloarthropathies may be thought of as the early onset of the same disease which is seen in adults. The autoinflammatory disorders appear to be of clear genetic origin, accounting for their frequent discovery in childhood. For many other conditions, such as juvenile dermatomyositis, the relationship between the conditions seen in children and that seen in adults is less certain. This book explores these phenomena, giving users a foundation on which to understand certain diseases. Includes completely updated chapters and five new chapters Explains the differences in systemic autoimmune diseases seen in children vs. those seen in adults Covers the latest advances in pathogenesis and clinical management of common conditions seen in pediatric rheumatology practices, benefiting both pediatric and adult rheumatologists, as well as physicians from other specialties Brings the reader up-to-date and allows easy access to individual topics in one place Provides the latest information available in a format that would give the clinician both a clear understanding of what has been done in the past and a scientific basis for deciding what to do for the next afflicted child in their care

Types Manifestations Causes and Treatments of Autoimmune Sicknesses

Types  Manifestations  Causes and Treatments of Autoimmune Sicknesses
Author: Jackson MARK
Publsiher: Unknown
Total Pages: 33
Release: 2021-08-14
ISBN 10: 1928374650XXX
ISBN 13: 9798456567390
Language: EN, FR, DE, ES & NL

Types Manifestations Causes and Treatments of Autoimmune Sicknesses Book Review:

What is an autoimmune disease? An autoimmune disease is a condition in which your immune system mistakenly attacks your body. The immune system normally guards against germs like bacteria and viruses. When it senses these foreign invaders, it sends out an army of fighter cells to attack them. Normally, the immune system can tell the difference between foreign cells and your own cells. In an autoimmune disease, the immune system mistakes part of your body, like your joints or skin, as foreign. It releases proteins called autoantibodies that attack healthy cells. Some autoimmune diseases target only one organ. Type 1 diabetes damages the pancreas. Other diseases, like systemic lupus erythematous (SLE), affect the whole body. Why does the immune system attack the body? Doctors don't know exactly what causes the immune-system misfire. Yet some people are more likely to get an autoimmune disease than others. According to a 2014 study, women get autoimmune diseases at a rate of about 2 to 1 compared to men -- 6.4 percent of women vs. 2.7 percent of men. Often the disease starts during a woman's childbearing years (ages 15 to 44). Some autoimmune diseases are more common in certain ethnic groups. For example, lupus affects more African-American and Hispanic people than Caucasians. Certain autoimmune diseases, like multiple sclerosis and lupus, run in families. Not every family member will necessarily have the same disease, but they inherit a susceptibility to an autoimmune condition. Because the incidence of autoimmune diseases is rising, researchers suspect environmental factors like infections and exposure to chemicals or solvents might also be involved. A "Western diet" is another suspected risk factor for developing an autoimmune disease. Eating high-fat, high-sugar, and highly processed foods is thought to be linked to inflammation, which might set off an immune response. However, this hasn't been proven. A 2015 study focused on another theory called the hygiene hypothesis. Because of vaccines and antiseptics, children today aren't exposed to as many germs as they were in the past. The lack of exposure could make their immune system prone to overreact to harmless substances. BOTTOM LINE: Researchers don't know exactly what causes autoimmune diseases. Genetics, diet, infections, and exposure to chemicals might be involved.

Biologic Markers in Immunotoxicology

Biologic Markers in Immunotoxicology
Author: National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Biologic Markers,Subcommittee on Immunotoxicology
Publsiher: National Academies Press
Total Pages: 224
Release: 1992-02-01
ISBN 10: 0309043891
ISBN 13: 9780309043892
Language: EN, FR, DE, ES & NL

Biologic Markers in Immunotoxicology Book Review:

Are environmental pollutants threatening the human immune system? Researchers are rapidly approaching definitive answers to this question, with the aid of biologic markers--sophisticated assessment tools that could revolutionize detection and prevention of certain diseases. This volume, third in a series on biologic markers, focuses on the human immune system and its response to environmental toxicants. The authoring committee provides direction for continuing development of biologic markers, with strategies for applying markers to immunotoxicology in humans and recommended outlines for clinical and field studies. This comprehensive, up-to-date volume will be invaluable to specialists in toxicology and immunology and to biologists and investigators involved in the development of biologic markers.