Industrial Process Scale up

Industrial Process Scale up
Author: Jan Harmsen
Publsiher: Elsevier
Total Pages: 112
Release: 2013-04-25
ISBN 10: 0444627391
ISBN 13: 9780444627391
Language: EN, FR, DE, ES & NL

Industrial Process Scale up Book Review:

This book will help industrial process innovators in research, development and commercial start-up to assess the risks of commercial-scale implementation and provide them with practical guidelines and methods to reduce the risks to acceptable levels. The book can also be used in co-operation with industrial R&D people and academic researchers to shape open innovation programs and in education as a reference book for process innovation courses. Offers easily accessible, step-by-step, and concise guidelines for industrial process scale-up Explains each stage of the innovation funnel: research, development, demonstration, commercial implementation for any process type and branch Based on industrial experiences and practices, which reduces the risks of commercial scale implementation of new processes to acceptable levels and reduces cost and time of process innovation Very clear, attractive layout, using text boxes that contain clarifying notes and additional information on specific topics, which makes it a quick reference of main subjects and additional information

Industrial Process Scale Up

Industrial Process Scale Up
Author: Jan Harmsen
Publsiher: Elsevier Science Limited
Total Pages: 116
Release: 2013
ISBN 10: 9780444627261
ISBN 13: 044462726X
Language: EN, FR, DE, ES & NL

Industrial Process Scale Up Book Review:

This book will help industrial process innovators in research, development and commercial start-up to assess the risks of commercial-scale implementation and provide them with practical guidelines and methods to reduce the risks to acceptable levels. The book can also be used in co-operation with industrial R&D people and academic researchers to shape open innovation programs and in education as a reference book for process innovation courses. Offers easily accessible, step-by-step, and concise guidelines for industrial process scale-up Explains each stage of the innovation funnel: research, development, demonstration, commercial implementation for any process type and branch Based on industrial experiences and practices, which reduces the risks of commercial scale implementation of new processes to acceptable levels and reduces cost and time of process innovation Very clear, attractive layout, using text boxes that contain clarifying notes and additional information on specific topics, which makes it a quick reference of main subjects and additional information

Scale up Methodology for Chemical Processes

Scale up Methodology for Chemical Processes
Author: Jean-Paul Euzen,Pierre Trambouze,Jean-Pierre Wauquier
Publsiher: Editions TECHNIP
Total Pages: 240
Release: 1993
ISBN 10: 9782710806462
ISBN 13: 2710806460
Language: EN, FR, DE, ES & NL

Scale up Methodology for Chemical Processes Book Review:

Having gained considerable experience in process development at the Institut FranCais du PEtrole, the authors present a design framework, a review of the available means of investigation, and several examples illustrating their methodology of industrial process scale up. The salient feature of the book is the fact that it addresses a subject which is vital in view of its economic repercussions, yet relatively unknown in technical and scientific circles, due to the confidentiality surrounding it.Contents: 1. Main guidelines of the methodology. 2. Various types of model. 3. Pilot plants and mock-ups. 4. Experimental techniques. 5. Applications to industrial process development. 6. Conclusions. References. Index.

Pharmaceutical Process Scale Up Third Edition

Pharmaceutical Process Scale Up  Third Edition
Author: Michael Levin
Publsiher: CRC Press
Total Pages: 530
Release: 2011-02-02
ISBN 10: 9781616310011
ISBN 13: 1616310014
Language: EN, FR, DE, ES & NL

Pharmaceutical Process Scale Up Third Edition Book Review:

The third edition of Pharmaceutical Process Scale-Up deals with the theory and practice of scale-up in the pharmaceutical industry. This thoroughly revised edition reflects the rapid changes in the field and includes: New material on tableting scale-up and compaction. Regulatory appendices that cover FDA and EU Guidelines. New chapters on risk evaluation and validation as related to scale-up. Practical advice on scale-up solutions from world renowned experts in the field. Pharmaceutical Process Scale-Up, Third Edition will provide an excellent insight in to the practical aspects of the process scale-up and will be an invaluable source of information on batch enlargement techniques for formulators, process engineers, validation specialists and quality assurance personnel, as well as production managers. It will also provide interesting reading material for anyone involved in Process Analytical Technology (PAT), technology transfer and product globalization.

Process Understanding

Process Understanding
Author: Ian Houson
Publsiher: John Wiley & Sons
Total Pages: 370
Release: 2011-06-09
ISBN 10: 3527637168
ISBN 13: 9783527637164
Language: EN, FR, DE, ES & NL

Process Understanding Book Review:

Process Understanding is the underpinning knowledge that allows the manufacture of chemical entities to be carried out routinely, robustly and to the required standard of quality. This area has gained in importance over the last few years, particularly due to the recent impetus from the USA`s Food and Drug Administration. This book covers the multidisciplinary aspects required for successful process design, safety, modeling, scale-up, PAT, pilot plant implementation, plant design as well the rapidly expanding area of outsourcing. In discussing what process understanding means to different disciplines and sectors throughout a product`s life cycle, this handbook and ready reference reveals the factors important to the development and manufacture of chemicals. The book focuses on the fundamental scientific understanding necessary. for a smoother technical transfer between the disciplines, leading to more effective and effi cient process development and manufacturing. A range of case studies are used to exemplify and illustrate the main issues raised. As a result, readers will appreciate that process understanding can deliver a real competitive advantage within the pharmaceuticals and fine chemicals industry. This book serves as an aid to meeting the stringent regulations required by the relevant authorities through demonstrable understanding of the underlying science.

Scaleup and Design of Industrial Mixing Processes

Scaleup and Design of Industrial Mixing Processes
Author: Gary B. Tatterson
Publsiher: Unknown
Total Pages: 392
Release: 2003
ISBN 10: 9780972663519
ISBN 13: 0972663517
Language: EN, FR, DE, ES & NL

Scaleup and Design of Industrial Mixing Processes Book Review:

Mistakes in process scaleup can be costly. This text is a comprehensive and highly practical source to all types of mixing and scaleup issues.

Chemical Projects Scale Up

Chemical Projects Scale Up
Author: Joe M. Bonem
Publsiher: Elsevier
Total Pages: 232
Release: 2018-05-31
ISBN 10: 0128137282
ISBN 13: 9780128137284
Language: EN, FR, DE, ES & NL

Chemical Projects Scale Up Book Review:

Chemical Projects Scale Up: How to Go from Laboratory to Commercial covers the chemical engineering steps necessary for taking a laboratory development into the commercial world. The book includes the problems associated with scale up, equipment sizing considerations, thermal characteristics associated with scale up, safety areas to consider, recycling considerations, operability reviews and economic viability. In addition to the process design aspects of commercializing the laboratory development, consideration is given to the utilization of a development in an existing plant. Explains how heat removal for exothermic reactions can be scaled up Outlines how a reactor can be sized from batch kinetic data Discusses how the plant performance of a new catalyst can be evaluated Presents how the economics of a new product/process can be developed Discusses the necessary evaluation of recycling in commercial plants

Scale up in Chemical Engineering

Scale up in Chemical Engineering
Author: Marko Zlokarnik
Publsiher: John Wiley & Sons
Total Pages: 296
Release: 2006-08-21
ISBN 10: 3527607765
ISBN 13: 9783527607761
Language: EN, FR, DE, ES & NL

Scale up in Chemical Engineering Book Review:

Covering the important task of the scale-up of processes from the laboratory to the production scale, this easily comprehensible and transparent book is divided into two sections. The first part details the theoretical principles, introducing the subject for readers without a profound prior knowledge of mathematics. It discusses the fundamentals of dimensional analysis, the treatment of temperature-dependent and rheological material values and scale-up where model systems or not available or only partly similar. All this is illustrated by 20 real-world examples, while 25 exercises plus solutions new to this edition practice and monitor learning. The second part presents the individual basic operations and covers the fields of mechanical, thermal, and chemical process engineering with respect to dimensional analysis and scale-up. The rules for scale-up are given and discussed for each operation. Other additions to this second edition are dimensional analysis of pelleting processes, and a historical overview of dimensional analysis and modeling, while all the chapters have been updated to take the latest literature into account. Written by a specialist with more than 40 years of experience in the industry, this book is specifically aimed at students as well as practicing engineers, chemists and process engineers already working in the field.

Process Scale Bioseparations for the Biopharmaceutical Industry

Process Scale Bioseparations for the Biopharmaceutical Industry
Author: Abhinav A. Shukla,Mark R. Etzel,Shishir Gadam
Publsiher: CRC Press
Total Pages: 575
Release: 2006-07-07
ISBN 10: 1420016024
ISBN 13: 9781420016024
Language: EN, FR, DE, ES & NL

Process Scale Bioseparations for the Biopharmaceutical Industry Book Review:

The biopharmaceutical industry has become an increasingly important player in the global economy, and the success of these products depends on the development and implementation of cost-effective, robust and scaleable production processes. Bioseparations-also called downstream processing- can be a key source of competitive advantageto biopharmaceutical developers. Process Scale Bioseparations for the Biopharmaceutical Industry brings together scientific principles, empirical approaches, and practical considerations for designing industrial downstream bioprocesses for various classes of biomolecules. Using clear language along with numerous case studies, examples, tables, flow charts, and schematics, the book presents perspectives from experienced professionals involved in purification processes and industrial downstream unit operations. The authors provide useful experimental design strategies and guidelines for developing application-specific process scale bioseparations. Chapter topics include harvest by centrifugation and filtration, expanded bed chromatography, protein refolding, modes of preparative chromatography, methodologies for resin screening, membrane chromatography, protein crystallization, viral filtration, ultrafiltration/diafiltration, implementing post-approval downstream process changes for an antibody product, and future trends. Ideal for both new and experienced scientists in the biopharmaceutical industry and students, Process Scale Bioseparations for the Biopharmaceutical Industry is a comprehensive resource for all topics relevant to industrial process development.

Scaleup of Chemical Processes

Scaleup of Chemical Processes
Author: Attilio Bisio,Bisio,Robert Lynn Kabel,Robert L. Kabel
Publsiher: Wiley-Interscience
Total Pages: 699
Release: 1985-07-25
ISBN 10:
ISBN 13: UOM:39015010893249
Language: EN, FR, DE, ES & NL

Scaleup of Chemical Processes Book Review:

The focus of this book is on the technical factors that are critical to th e design and startup of a commercial manufacturing facility.

Food Processing Operations and Scale up

Food Processing Operations and Scale up
Author: Kenneth J. Valentas,J. Peter Clark,Leon Levin
Publsiher: CRC Press
Total Pages: 408
Release: 2020-08-12
ISBN 10: 1000147568
ISBN 13: 9781000147568
Language: EN, FR, DE, ES & NL

Food Processing Operations and Scale up Book Review:

Intended for students and practitioners who have a basic education in chemical engineering or food science. Contains basic information in each area and describes some of the fundamental ideas of processing development and design. Examines the food industry structure, how it works, consumer products,

Scaling Chemical Processes

Scaling Chemical Processes
Author: Jonathan Worstell
Publsiher: Butterworth-Heinemann
Total Pages: 186
Release: 2016-10-27
ISBN 10: 0128047690
ISBN 13: 9780128047699
Language: EN, FR, DE, ES & NL

Scaling Chemical Processes Book Review:

Scaling Chemical Processes: Practical Guides in Chemical Engineering is one of a series of short texts that each provides a focused introductory view on a single subject. The full library spans the main topics in the chemical process industries for engineering professionals who require a basic grounding in various related topics. They are ‘pocket publications’ that the professional engineer can easily carry with them or access electronically while working. Each text is highly practical and applied, and presents first principles for engineers who need to get up to speed in a new area fast. The focused facts provided in each guide will help you converse with experts in the field, attempt your own initial troubleshooting, check calculations, and solve rudimentary problems. This book discusses scaling chemical processes from a laboratory through a pilot plant to a commercial plant. It bases scaling on similarity principles and uses dimensional analysis to derive the dimensionless parameters necessary to ensure a successful chemical process development program. This series is fully endorsed and co-branded by the IChemE, and they help to promote the series. Offers practical, short, concise information on the basics to help you get an answer or teach yourself a new topic quickly Includes industry examples to help you solve real world problems Provides key facts for professionals in convenient single subject volumes Discusses scaling chemical processes from a laboratory through a pilot plant to a commercial plant

Pharmaceutical Process Chemistry for Synthesis

Pharmaceutical Process Chemistry for Synthesis
Author: Peter J. Harrington
Publsiher: John Wiley & Sons
Total Pages: 376
Release: 2011-02-23
ISBN 10: 9780470922866
ISBN 13: 0470922869
Language: EN, FR, DE, ES & NL

Pharmaceutical Process Chemistry for Synthesis Book Review:

There is a need to explain that generic versions of a drug may not be manufactured by the same process as brand-name drugs and that the different processes may have dramatically different environmental impacts. Two global forces are at odds today—the push for "greener" processes and the push for lower drug prices. This book brings this conflict into sharp focus by discussing in detail the published process chemistry for top-selling small molecule drugs. Providing insights about process route selection, choice of reagents, and reaction conditions, Pharmaceutical Process Chemistry for Synthesis guides process chemists in identifying best processes for manufacturing these blockbuster drugs as they lose patent protection. Further, it highlights the strategies and methodology that might be useful for expediting the process research and development of the blockbusters of the future. Written from a refreshingly objective perspective, this book is essential for process chemists who need to devise practical syntheses for increasingly complex drugs in a constantly decreasing time frame.

Practical Process Research and Development A guide for Organic Chemists

Practical Process Research and Development     A guide for Organic Chemists
Author: Neal G. Anderson
Publsiher: Academic Press
Total Pages: 488
Release: 2012-05-23
ISBN 10: 0123865387
ISBN 13: 9780123865380
Language: EN, FR, DE, ES & NL

Practical Process Research and Development A guide for Organic Chemists Book Review:

Designed to provide a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries, this book describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. It describes hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." Second Edition highlights: • Reflects the current thinking in chemical process R&D for small molecules • Retains similar structure and orientation to the first edition. • Contains approx. 85% new material • Primarily new examples (work-up and prospective considerations for pilot plant and manufacturing scale-up) • Some new/expanded topics (e.g. green chemistry, genotoxins, enzymatic processes) • Replaces the first edition, although the first edition contains useful older examples that readers may refer to Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more Presents guidelines for implementing and troubleshooting processes

Process Scaleup and Design

Process Scaleup and Design
Author: Gary B. Tatterson
Publsiher: Gary Tatterson
Total Pages: 188
Release: 2002
ISBN 10: 9780972663502
ISBN 13: 0972663509
Language: EN, FR, DE, ES & NL

Process Scaleup and Design Book Review:

Process Scaleup and Design provides the general methods used to scaleup a process. The book contains how to: 1) set process objectives for scaleup, 2) use the basic concepts of scaleup, 3) use various scaleup methods, 4) avoid mistakes in scaleup, 5) utilize process options, 6) benefit from understanding unpredictability, 7) treat the business of scaleup and 8) improve safety.

Protein Chromatography

Protein Chromatography
Author: Giorgio Carta,Alois Jungbauer
Publsiher: John Wiley & Sons
Total Pages: 432
Release: 2020-06-02
ISBN 10: 352734666X
ISBN 13: 9783527346660
Language: EN, FR, DE, ES & NL

Protein Chromatography Book Review:

An all-in-one practical guide on how to efficiently use chromatographic separation methods Based on a training course that teaches the theoretical as well as practical aspects of protein bioseparation to bioprocess professionals, this fully updated and revised new edition offers comprehensive coverage of continuous chromatography and provides readers with many relevant examples from the biopharmaceutical industry. Divided into two large parts, Protein Chromatography: Process Development and Scale-Up, Second Edition presents all the necessary knowledge for effective process development in chromatographic bioseparation, both on small and large scale. The first part introduces chromatographic theory, including process design principles, to enable the reader to rationalize the set-up of a bioseparation process. The second part illustrates by way of case studies and sample protocols how the theory learned in the first part may be applied to real-life problems. Chapters look at: Downstream Processing of Biotechnology Products; Chromatography Media; Laboratory and Process Columns and Equipment; Adsorption Equilibrium; Rate Processes; and Dynamics of Chromatography Columns. The book closes with chapters on: Effects of Dispersion and Rate Processes on Column Performance; Gradient Elution Chromatography; and Chromatographic Column Design and Optimization. -Presents the most pertinent examples from the biopharmaceutical industry, including monoclonal antibodies -Provides an overview of the field along with design tools and examples illustrating the advantages of continuous processing in biopharmaceutical productions -Focuses on process development and large-scale bioseparation tasks, making it an ideal guide for the professional bioengineer in the biotech and pharma industries -Offers field-tested information based on decades of training courses for biotech and chemical engineers in Europe and the U.S. Protein Chromatography: Process Development and Scale-Up, Second Edition will appeal to biotechnologists, analytical chemists, chromatographers, chemical engineers, pharmaceutical industry, biotechnological industry, and biochemists.

The Pilot Plant Real Book

The Pilot Plant Real Book
Author: Francis X. McConville
Publsiher: Fxm Engineering & Design
Total Pages: 320
Release: 2006-12-01
ISBN 10: 9780972176927
ISBN 13: 0972176926
Language: EN, FR, DE, ES & NL

The Pilot Plant Real Book Book Review:

Solid Liquid Separation Equipment Selection and Process Design

Solid Liquid Separation  Equipment Selection and Process Design
Author: Steve Tarleton,Richard Wakeman
Publsiher: Elsevier
Total Pages: 464
Release: 2006-12-07
ISBN 10: 9780080467177
ISBN 13: 0080467172
Language: EN, FR, DE, ES & NL

Solid Liquid Separation Equipment Selection and Process Design Book Review:

In this volume, the third in a set specifically written for the industrial process and chemical engineer, the authors provide the detailed information on filtration equipment and media which allows the reader to then consider the pre-treatment of suspensions, selection of the most appropriate equipment for the task, data analysis and the subsequent design of the processes involved for particular separations. The result is a comprehensive book which is designed to be used frequently and referred to regularly in order to achieve better industrial separations. Successful industrial-scale separation of solids from liquids requires not only a thorough understanding of the principles involved, but also an appreciation of which equipment to use for best effect, and a start-to-finish plan for the various processes involved in the operation. If these factors are all correct, then successful separations should result. Part of 3-volume set Unique approach to industrial separations Internationally-known authors

Electro Fenton Process

Electro Fenton Process
Author: Minghua Zhou,Mehmet A. Oturan,Ignasi Sirés
Publsiher: Springer
Total Pages: 430
Release: 2017-11-25
ISBN 10: 9811064067
ISBN 13: 9789811064067
Language: EN, FR, DE, ES & NL

Electro Fenton Process Book Review:

This volume discusses the theoretical fundamentals and potential applications of the original electro-Fenton (EF) process and its most innovative and promising versions, all of which are classified as electrochemical advanced oxidation processes. It consists of 15 chapters that review the latest advances and trends, material selection, reaction and reactor modeling and EF scale-up. It particularly focuses on the applications of EF process in the treatment of toxic and persistent organic pollutants in water and soil, showing highly efficient removal for both lab-scale and pre-pilot setups. Indeed, the EF technology is now mature enough to be brought to market, and this collection of contributions from leading experts in the field constitutes a timely milestone for scientists and engineers.

Nanoscale Fabrication Optimization Scale up and Biological Aspects of Pharmaceutical Nanotechnology

Nanoscale Fabrication  Optimization  Scale up and Biological Aspects of Pharmaceutical Nanotechnology
Author: Alexandru Mihai Grumezescu
Publsiher: William Andrew
Total Pages: 696
Release: 2017-12-11
ISBN 10: 0128136308
ISBN 13: 9780128136300
Language: EN, FR, DE, ES & NL

Nanoscale Fabrication Optimization Scale up and Biological Aspects of Pharmaceutical Nanotechnology Book Review:

Nanoscale Fabrication, Optimization, Scale-up and Biological Aspects of Pharmaceutical Nanotechnology focuses on the fabrication, optimization, scale-up and biological aspects of pharmaceutical nanotechnology. In particular, the following aspects of nanoparticle preparation methods are discussed: the need for less toxic reagents, simplification of the procedure to allow economic scale-up, and optimization to improve yield and entrapment efficiency. Written by a diverse range of international researchers, the chapters examine characterization and manufacturing of nanomaterials for pharmaceutical applications. Regulatory and policy aspects are also discussed. This book is a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about how nanomaterials can best be utilized. Shows how nanomanufacturing techniques can help to create more effective, cheaper pharmaceutical products Explores how nanofabrication techniques developed in the lab have been translated to commercial applications in recent years Explains safety and regulatory aspects of the use of nanomanufacturing processes in the pharmaceutical industry