Improving the Therapeutic Ratio in Head and Neck Cancer

Improving the Therapeutic Ratio in Head and Neck Cancer
Author: Anonim
Publsiher: Academic Press
Total Pages: 376
Release: 2019-10-04
ISBN 10: 0128178698
ISBN 13: 9780128178690
Language: EN, FR, DE, ES & NL

Improving the Therapeutic Ratio in Head and Neck Cancer Book Review:

Improving the Therapeutic Ratio in Head and Neck Cancer provides a complete review of current approaches to modulating therapeutic sensitivity in head and neck cancer. It presents a broad background of current approaches and by highlighting the potential for clinical translational, introduces a roadmap for how to move promising preclinical findings into the clinic. The book discusses topics such as immunotherapy and molecularly targeted therapies in head and neck cancer, PI3k/mTOR pathway, autophagy inhibition to sensitize HNC to radiation and chemotherapy, TAM and Eph/Ephrin family proteins and metabolic reprogramming to modulate therapeutic sensitivity. Additionally, it details approaches to improve the response to immunotherapy, and Chk1/2 inhibition in radiation and cetuximab resistance. This book is a valuable source to head and neck cancer researchers and advanced students, and to those studying specific approaches in other model systems and disease sites. Provides key scientific background for clinicians when developing novel clinical trials and important examples for basic scientists of the types of work required to move a concept from the lab to the clinic Presents consistent pathway diagrams in each chapter, thus making it easier to understand complicated pathways Includes chapter summaries of the critical next steps needed to move studies from their current state into practice changing clinical data

Increasing the Therapeutic Ratio of Radiotherapy

Increasing the Therapeutic Ratio of Radiotherapy
Author: Philip J. Tofilon,Kevin Camphausen
Publsiher: Springer
Total Pages: 280
Release: 2016-11-21
ISBN 10: 3319408542
ISBN 13: 9783319408545
Language: EN, FR, DE, ES & NL

Increasing the Therapeutic Ratio of Radiotherapy Book Review:

Current cancer therapies are focused on three general strategies: modifying intrinsic radiosensitivity via molecular targeting, manipulating microenvironmental factors to enhance tumor susceptibility to radiation, and improving delivery of radiation to critical tumor locations while sparing normal tissues. The goal of this volume is to describe a number of promising approaches corresponding to each strategy. In general, research in radiation oncology tends to be siloed into fundamental biology, physics or treatment delivery. The strategies for improving therapeutic ratio encompassed in this book will involve each of these components of radiation oncology. Thus, they will illustrate the variety of disparate approaches available for potentially improving the efficacy of radiotherapy, which may then stimulate discussion across disciplines and foster further translational investigations. Although a goal of each chapter will be to highlight advances within an approach, of equal importance will be the delineation of barriers to successful clinical application and how to overcome or minimize such impediments. Along these lines, because therapeutic ratio incorporates both tumor and normal tissue radio response, a point of emphasis will be the mechanistic rationale for selectively modifying tumor (sensitization) or normal cells (protection). Finally, whereas the literature is replete with studies describing potential targets/strategies for increasing the therapeutic ratio for radiotherapy, this book will focus on those supported by in vivo data consistent with impending translational application along with those that are already being evaluated in the clinic.

International Journal of Radiation Oncology Biology Physics

International Journal of Radiation Oncology  Biology  Physics
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 1986
ISBN 10:
ISBN 13: NWU:35558000969648
Language: EN, FR, DE, ES & NL

International Journal of Radiation Oncology Biology Physics Book Review:

Strategies to Enhance the Therapeutic Ratio of Radiation as a Cancer Treatment

Strategies to Enhance the Therapeutic Ratio of Radiation as a Cancer Treatment
Author: Mitchell S. Anscher,Kristoffer Valerie
Publsiher: Springer
Total Pages: 305
Release: 2016-10-20
ISBN 10: 331945594X
ISBN 13: 9783319455945
Language: EN, FR, DE, ES & NL

Strategies to Enhance the Therapeutic Ratio of Radiation as a Cancer Treatment Book Review:

This volume will describe recent progress and future directions in radiation oncology and biology research, focusing on strategies designed to improve disease control and reduce the risk of long-term adverse effects on patients. As more and more patients are becoming long-term survivors, this strategy will become increasingly important--in radiation oncology and throughout the field of oncology.

Disease Control Priorities Third Edition Volume 3

Disease Control Priorities  Third Edition  Volume 3
Author: Hellen Gelband,Prabhat Jha,Rengaswamy Sankaranarayanan,Susan Horton
Publsiher: World Bank Publications
Total Pages: 360
Release: 2015-10-29
ISBN 10: 1464803692
ISBN 13: 9781464803697
Language: EN, FR, DE, ES & NL

Disease Control Priorities Third Edition Volume 3 Book Review:

Volume 3, Cancer, presents the complex patterns of cancer incidence and death around the world and evidence on effective and cost-effective ways to control cancers. The DCP3 evaluation of cancer will indicate where cancer treatment is ineffective and wasteful, and offer alternative cancer care packages that are cost-effective and suited to low-resource settings. Main messages from the volume include: -Quality matters in all aspects of cancer treatment and palliation. -Cancer registries that track incidence, mortality, and survival †“ paired with systems to capture causes of death are important to understanding the national cancer burden and the effect of interventions over time. -Effective interventions exist at a range of prices. Adopting "resource appropriate" measures which allow the most effective treatment for the greatest number of people will be advantageous to countries. -Prioritizing resources toward early stage and curable cancers is likely to have the greatest health impact in low income settings. -Research prioritization is no longer just a global responsibility. Providing cancer treatment requires adequate numbers of trained healthcare professionals and infrastructure beyond what is available in most LMICs, especially low income countries. Careful patient monitoring is a requirement of good quality cancer care and this often involves laboratory tests in addition to clinical examination. Even if financing were immediately available to build or expand a cancer control system, reaching capacity will take many years.

Intensity Modulated Radiation Therapy

Intensity Modulated Radiation Therapy
Author: S. Webb
Publsiher: CRC Press
Total Pages: 454
Release: 2001-01-01
ISBN 10: 1420034111
ISBN 13: 9781420034110
Language: EN, FR, DE, ES & NL

Intensity Modulated Radiation Therapy Book Review:

Clinical conformal radiotherapy is the holy grail of radiation treatment and is now becoming a reality through the combined efforts of physical scientists and engineers, who have improved the physical basis of radiotherapy, and the interest and concern of imaginative radiotherapists and radiographers. Intensity-Modulated Radiation Therapy describes in detail the physics germane to the development of a particular form of clinical conformal radiotherapy called intensity modulated radiation therapy (IMRT). IMRT has become a topic of tremendous importance in recent years and is now being seriously investigated for its potential to improve the outcome of radiation therapy. The book collates the state-of-the-art literature together with the author's personal research experience and that of colleagues in the field to produce a text suitable for new research workers, Ph.D. students, and practicing radiation physicists that require a thorough introduction to IMRT. Fully illustrated, indexed, and referenced, the book has been prepared in a form suitable for supporting a teaching course.

Intensity Modulated Radiation Therapy for Head and Neck Cancer

Intensity Modulated Radiation Therapy for Head and Neck Cancer
Author: K. S. Clifford Chao,Gokhan Ozyigit
Publsiher: Lippincott Raven
Total Pages: 173
Release: 2003
ISBN 10:
ISBN 13: UOM:39015056258653
Language: EN, FR, DE, ES & NL

Intensity Modulated Radiation Therapy for Head and Neck Cancer Book Review:

The first clinical book on the hottest topic in radiation oncology, this timely teaching text offers step-by-step guidance in use of IMRT for cancers at each subsite of the head and neck. The book's high-end content gives readers the clinical decision-making expertise and technical proficiency to incorporate this state-of-the-art radiation treatment technique into practice. Unique to this text is the site-specific instruction on target determination and delineation, to ensure adequate treatment of the tumor target while sparing adjacent normal tissue. More than 250 detailed full-color and black-and-white illustrations clarify each step in clinical implementations of head and neck cancer treatment, especially IMRT. The book provides a concise, pertinent overview of the natural course, lymph node spread, diagnostic criteria, and therapeutic options for each head and neck cancer subsite. Numerous tables provide extensive summaries of the IMRT literature. Figures with succinct explanatory text demonstrate the patterns of direct tumor extension and nodal metastasis with which target volumes are determined and delineated. Clinical outcomes for patients treated with IMRT and with conventional techniques are also included.

Adaptive Radiation Therapy

Adaptive Radiation Therapy
Author: X. Allen Li
Publsiher: CRC Press
Total Pages: 426
Release: 2011-01-27
ISBN 10: 9781439816356
ISBN 13: 1439816352
Language: EN, FR, DE, ES & NL

Adaptive Radiation Therapy Book Review:

Modern medical imaging and radiation therapy technologies are so complex and computer driven that it is difficult for physicians and technologists to know exactly what is happening at the point-of-care. Medical physicists responsible for filling this gap in knowledge must stay abreast of the latest advances at the intersection of medical imaging and radiation therapy. This book provides medical physicists and radiation oncologists current and relevant information on Adaptive Radiation Therapy (ART), a state-of-the-art approach that uses a feedback process to account for patient-specific anatomic and/or biological changes, thus delivering highly individualized radiation therapy for cancer patients. The book should also benefit medical dosimetrists and radiation therapists. Adaptive Radiation Therapy describes technological and methodological advances in the field of ART, as well as initial clinical experiences using ART for selected anatomic sites. Divided into three sections (radiobiological basis, current technologies, and clinical applications), the book covers: Morphological and biological biomarkers for patient-specific planning Design and optimization of treatment plans Delivery of IMRT and IGRT intervention methodologies of ART Management of intrafraction variations, particularly with respiratory motion Quality assurance needed to ensure the safe delivery of ART ART applications in several common cancer types / anatomic sites The technology and methodology for ART have advanced significantly in the last few years and accumulated clinical data have demonstrated the need for ART in clinical settings, assisted by the wide application of intensity modulated radiation therapy (IMRT) and image-guided radiation therapy (IGRT). This book shows the real potential for supplying every patient with individualized radiation therapy that is maximally accurate and precise.

Current Opinion in Oncology

Current Opinion in Oncology
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 1995
ISBN 10:
ISBN 13: UCLA:L0074442898
Language: EN, FR, DE, ES & NL

Current Opinion in Oncology Book Review:

Head and Neck Cancer

Head and Neck Cancer
Author: John Frederick Ensley,Silvio Gutkind,John A. Jacobs,Scott Lippman
Publsiher: Elsevier
Total Pages: 602
Release: 2003-01-07
ISBN 10: 9780080533841
ISBN 13: 0080533841
Language: EN, FR, DE, ES & NL

Head and Neck Cancer Book Review:

By detailing experimental and basic research, from premalignancy to fully invasive tumors, this book has wide applicability to all human carcinomas. No other group of human cancers is better positioned for the application of recently developed novel and targeted therapies, and this book uniquely presents the unusual opportunities tumors of the head and neck provide for clinical, translational, and basic science research. Cutting-edge and experimental treatment approaches are presented, along with future strategies and an evaluation of emerging technologies. Presents a multi-disciplinary perspective from authorities in diverse fields Addresses state-of-the art approaches in cancer research as well as other scientific opportunities in this field Provides comprehensive yet easily comprehendible source of information

Management of Oral Cancer

Management of Oral Cancer
Author: Nicholas Stafford,John Waldron
Publsiher: Oxford University Press, USA
Total Pages: 214
Release: 1989
ISBN 10:
ISBN 13: UOM:39015017701247
Language: EN, FR, DE, ES & NL

Management of Oral Cancer Book Review:

This is the first fully interdisciplinary work on the care of patients with oral cancer. It features contributions from experts in many areas of head and neck oncology, and sets out guidelines for the treatment of oral cavity and oropharyngeal tumors at all stages and sites. The volume provides expert coverage of two preferred methods of treatment, as well as in-depth discussion of functional anatomy, pathology, and the principles and practicalities of radiotherapy and chemotherapy. It provides readers with in-depth analysis of surgical reconstruction, treating cervical lymphatics, and full guidance on applications of laser treatment, managing specific complications of treatment, and functional rehabilitation of speech and swallowing.

Contemporary Issues in Head and Neck Cancer Management

Contemporary Issues in Head and Neck Cancer Management
Author: Loredana Marcu
Publsiher: BoD – Books on Demand
Total Pages: 180
Release: 2015-07-08
ISBN 10: 9535121359
ISBN 13: 9789535121350
Language: EN, FR, DE, ES & NL

Contemporary Issues in Head and Neck Cancer Management Book Review:

While the management of head and neck cancer has evolved over the last few decades, there are still several challenges and unanswered questions that need solutions. This book is a small compilation of some topical aspects regarding head and neck cancer treatment, including the etiology of HPV-positive oropharyngeal cancers and risk factors in the young population, the challenge of surgical margin definition and the perennial problem of systemic treatment due to distant metastases. Radiobiological aspects are also covered through the Rs of radiotherapy, with a couple of chapters being dedicated to radioresistance and tumour microenvironment. Contemporary Issues in Head and Neck Cancer Management comes as an addition to the existing literature that aims to tackle this radiobiologically challenging tumour.

Journal of the National Cancer Institute

Journal of the National Cancer Institute
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 1996
ISBN 10:
ISBN 13: NWU:35558004792541
Language: EN, FR, DE, ES & NL

Journal of the National Cancer Institute Book Review:

"Summaries of papers" contained in the journal accompany each issue, 19--

Radiotherapy in Clinical Practice

Radiotherapy in Clinical Practice
Author: H. F. Hope-Stone
Publsiher: Butterworth-Heinemann
Total Pages: 454
Release: 1986
ISBN 10:
ISBN 13: UOM:39015010147042
Language: EN, FR, DE, ES & NL

Radiotherapy in Clinical Practice Book Review:

Volume and Kinetics in Tumor Control and Normal Tissue Complications

Volume and Kinetics in Tumor Control and Normal Tissue Complications
Author: Donald Herbert
Publsiher: American Institute of Physics
Total Pages: 483
Release: 1998-08-07
ISBN 10:
ISBN 13: UOM:39015055901097
Language: EN, FR, DE, ES & NL

Volume and Kinetics in Tumor Control and Normal Tissue Complications Book Review:

This volume places a strong emphasis on "volume-effects" phenomenon & the radiation pharmacokinetics that is required to achieve timely & accurate predictions of the clinically acceptable radiation responses in the tumor & normal tissues. Such findings are especially appropriate to the current period of self-examination & introspection by the medical profession occasioned by the augmenting concerns of payors & patients alike for the appropriateness & effectiveness of the increasing volume & intensity of medical services now delivered. The proceedings specifically discusses the topics of 3D & IMRT based therapies & their radiobiological & clinical impact.

The Journal of Laryngology and Otology

The Journal of Laryngology and Otology
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 1996
ISBN 10:
ISBN 13: UCLA:L0081750366
Language: EN, FR, DE, ES & NL

The Journal of Laryngology and Otology Book Review:

Cancer Forum

Cancer Forum
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 2006
ISBN 10:
ISBN 13: NWU:35558005663170
Language: EN, FR, DE, ES & NL

Cancer Forum Book Review:

The Tenth British Academic Conference in Otolaryngology

The Tenth British Academic Conference in Otolaryngology
Author: Anonim
Publsiher: Unknown
Total Pages: 62
Release: 1999
ISBN 10:
ISBN 13: IND:30000061573022
Language: EN, FR, DE, ES & NL

The Tenth British Academic Conference in Otolaryngology Book Review:

Current Surgical Diagnosis Treatment

Current Surgical Diagnosis   Treatment
Author: Lawrence W. Way
Publsiher: McGraw-Hill/Appleton & Lange
Total Pages: 1426
Release: 1994
ISBN 10:
ISBN 13: UOM:39015039975985
Language: EN, FR, DE, ES & NL

Current Surgical Diagnosis Treatment Book Review:

Current Surgical Diagnosis & Treatment covers over 1,000 diseases and disorders managed by surgeons. It encompasses general surgery and the surgical subspecialties and emphasizes quick recall of major diagnostic features and succinct descriptions of disease processes. This major revision and updating features a new chapter on "The Metabolic & Neuroendocrine Responses to Trauma & Operations," the latest on minimally invasive surgical techniques, and particularly extensive changes to chapters on oncology, colon and rectal surgery, plastic surgery, vascular surgery, and cardiothoracic surgery.

A Practical Guide to Intensity modulated Radiation Therapy

A Practical Guide to Intensity modulated Radiation Therapy
Author: Anonim
Publsiher: Medical Physics Publishing Corporation
Total Pages: 423
Release: 2003
ISBN 10:
ISBN 13: UOM:39015061337179
Language: EN, FR, DE, ES & NL

A Practical Guide to Intensity modulated Radiation Therapy Book Review:

This book provides an account of the perspective, methodology, and experience in the physical and medical aspects of IMRT at Memorial Sloan-Kettering Cancer Center (MSKCC). The clinicians and scientists at MSKCC were fortunate to be involved in the development and implementation of this advanced form of radiotherapy. MSKCC was also at the forefront of using IMRT treatment with the use of dynamic multileaf collimation (DMLC) in 1995. Since then, MSKCC has amassed a vast body of technical and clinical experience in the use of this modality.