Immunotherapeutic Strategies for the Treatment of Glioma

Immunotherapeutic Strategies for the Treatment of Glioma
Author: Michael Lim,Christopher Jackson
Publsiher: Academic Press
Total Pages: 250
Release: 2020-07-01
ISBN 10: 0128197560
ISBN 13: 9780128197561
Language: EN, FR, DE, ES & NL

Immunotherapeutic Strategies for the Treatment of Glioma Book Review:

Immunotherapeutic Strategies for the Treatment of Glioma provides a review of the current state of immunotherapy for primary brain tumors. The topic is of interest to patients, clinicians, and researchers alike, particularly given the recent failure of large clinical trials. This book serves as an overview of the most promising approaches in the field and provides a foundation for considering novel and combination therapies moving forward. The book discusses several types of immunotherapies for glioma, such as peptide, dendritic cell and heat shock protein vaccines; immune checkpoint blockade; myeloid cells as target; oncolytic viruses; and CAR T cell therapy. Additionally, it discusses the mechanisms of immune suppression in patients and immunogenomics. This volume is a valuable source for cancer researchers, oncologists and several members of biomedical field who are interested in novel strategies to fight glioblastoma. Summarizes the work in immunotherapy for glioma to-date, including the available evidence from preclinical studies and clinical trials Reviews the challenges and successes of the most promising strategies for brain tumor immunotherapy Provides a foundation for considering novel and combination therapies moving forward

Translational Immunotherapy of Brain Tumors

Translational Immunotherapy of Brain Tumors
Author: John H. Sampson
Publsiher: Academic Press
Total Pages: 404
Release: 2017-02-06
ISBN 10: 0128026251
ISBN 13: 9780128026250
Language: EN, FR, DE, ES & NL

Translational Immunotherapy of Brain Tumors Book Review:

Translational Immunotherapy of Brain Tumors gives researchers and practitioners an up-to-date and comprehensive overview of the field. Chapters include adoptive immunotherapy, immunosuppression, CAR therapy of brain tumors, and dendritic cell therapy for brain tumors. Very few agents have been shown to be efficacious in the treatment of malignant gliomas. Recently, there have been a number of studies demonstrating the potential success of immunotherapy for brain tumors. Immunotherapeutics are becoming the most frequent drugs to be used in cancer therapy. These new breakthroughs, now approved by the FDA, are a part of multiple phase III international trials and ongoing research in malignant glioma, meaning that the information in this cutting-edge book will be of great importance to practitioners and researchers alike. Comprehensive overview, providing an update on immunology, translational immunotherapy, and clinical trials relating to malignant gliomas Edited by a prominent neurosurgeon with contributions by leading researchers in the field Ideal resource for researchers and practitioners interested in learning about mechanisms that use the immune system to treat brain tumors

Impact of Immunotherapy in the Treatment of Glioblastoma

Impact of Immunotherapy in the Treatment of Glioblastoma
Author: Jessica Silva
Publsiher: Anonim
Total Pages: 329
Release: 2018
ISBN 10:
ISBN 13: OCLC:1154234821
Language: EN, FR, DE, ES & NL

Impact of Immunotherapy in the Treatment of Glioblastoma Book Review:

Glioblastoma multiforme (GBM) is the most common and aggressive primary malignant brain tumor. Despite the efforts developed in the respective treatment, consisting of maximal surgical resection followed by adjuvant radiotherapy and chemotherapy, the prognosis remains very poor. This may be partly related to the resistance of GBM cells and their infiltrative and invasive nature into the surrounding brain tissue. Therefore, newer and challenging alternative approaches for the treatment have emerged, including immunotherapy. This anticancer therapy, based on the stimulation of the host's immune system, has been currently investigated and several advances in the clinical trial stage have already been reached. Immunotherapeutic strategies comprise a set of modalities, including vaccines (cell-free and cell-based), chimeric antigen receptor (CAR) T-cell therapy, immune checkpoint inhibitors, monoclonal antibodies (mAbs), and oncolytic viruses (OVs). In this chapter, we will review the principal concepts and the recent progress in immunotherapy for GBM.

Glioma

Glioma
Author: ryuya yamanaka
Publsiher: Springer Science & Business Media
Total Pages: 232
Release: 2012-05-27
ISBN 10: 1461431468
ISBN 13: 9781461431466
Language: EN, FR, DE, ES & NL

Glioma Book Review:

Treatment of glioma is currently one of the most challenging problems in oncology, as well as in neurosurgery. Despite major advances in our understanding of the pathomechanism, diagnosis by imaging and the availability of powerful therapeutic tools, the life expectancy of patients with glioblastoma has only been slightly prolonged and a cure remains elusive. None of the currently available surgical tools, including operative microscopes, lasers and image-guided surgery, can enable the detection and removal of all of the tumor tissue. In recent years, however, the landscape has been changing immeasurably, and molecular studies over the past two decades have identified a variety of genetic aberrations that are specifically associated with individual types of gliomas. In addition, certain molecular abnormalities have been linked to therapy responses, thereby establishing clinical biomarkers and molecular targets, and the use of novel agents is being investigated. These agents have been specifically engineered to exert specific cytotoxicity against gliomas, either on their own as single agents or in combination with other modalities. Moreover, there has been an enormous surge of interest in the area of immunology and immunotherapy, which has been facilitated by our understanding of the molecular basis of gliomas. Although several kinds of immunotherapeutic trials have been undertaken, we still await a great breakthrough in terms of clinical efficacy to prolong the survival time of glioma patients.

Modern Management of High Grade Glioma Part II An Issue of Neurosurgery Clinics E Book

Modern Management of High Grade Glioma  Part II  An Issue of Neurosurgery Clinics   E Book
Author: Isaac Yang,Seunggu J. Han
Publsiher: Elsevier Health Sciences
Total Pages: 240
Release: 2012-07-15
ISBN 10: 1455747688
ISBN 13: 9781455747689
Language: EN, FR, DE, ES & NL

Modern Management of High Grade Glioma Part II An Issue of Neurosurgery Clinics E Book Book Review:

Standard therapy for high grade glioma is a topic that is evolving, timely, and relevant. Guest Editors Isaac Yang, MD and Seunggu Han, MD have assembled a group of experts on management of high grade glioma. Some of the articles in this issue include: Use of language mapping to aid resection of eloquent gliomas; Clinical trials with immunotherapy; Clinical trials for small molecule inhibitors; Nanotechnology potential applications for GBM therapy; High Grade Gliomas in children; Modern Advances in Brain Tumor Treatments; Molecular pathways of Avastin interactions for the treatment of glioblastoma; and Quality of Life and Outcomes in Glioblastoma management.

Brain Tumors

Brain Tumors
Author: Ana Lucia Abujamra
Publsiher: BoD – Books on Demand
Total Pages: 434
Release: 2011-08-23
ISBN 10: 9533075880
ISBN 13: 9789533075884
Language: EN, FR, DE, ES & NL

Brain Tumors Book Review:

Brain Tumors: Current and Emerging Therapeutic Strategies focuses on tumor models, the molecular mechanisms involved in the pathogenesis of this disease, and on the new diagnostic and treatment strategies utilized to stage and treat this malignancy. A special section on immunotherapy and gene therapy provides the most up-to-date information on the pre-clinical and clinical advances of this therapeutic venue. Each chapter in Brain Tumors: Current and Emerging Therapeutic Strategies is authored by international experts with extensive experience in the areas covered.

Intracranial Gliomas Part III Innovative Treatment Modalities

Intracranial Gliomas Part III   Innovative Treatment Modalities
Author: M.F. Chernov,Y. Muragaki,S. Kesari,I.E. McCutcheon
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 222
Release: 2018-07-10
ISBN 10: 3318060631
ISBN 13: 9783318060638
Language: EN, FR, DE, ES & NL

Intracranial Gliomas Part III Innovative Treatment Modalities Book Review:

At present most intracranial gliomas are considered incurable with current treatment strategies, and the search for new modalities that may effectively control tumor growth continues. The chapters in this volume describe basic principles and therapeutic possibilities of several innovative techniques, including photodynamic therapy, laser-induced interstitial thermotherapy, stereotactic cryodestruction, high-intensity focused ultrasound ablation, boron neutron capture therapy, proton and carbon ion irradiation, targeted therapy, immunotherapy, gene therapy, local chemotherapy, and alternating electric fields therapy. Potential applications of extracellular vesicles and nanotechnology for management of gliomas are highlighted as well. Many of these methods have already demonstrated antitumor efficacy in clinical testing, whereas others are still under development. The materials presented in this book are mainly directed at clinicians treating patients with brain tumors, as well as clinical and basic researchers working in the field of neuro-oncology.

Immunotherapy An Issue of Neurosurgery Clinics E Book

Immunotherapy  An Issue of Neurosurgery Clinics   E Book
Author: Isaac Yang,Michael J Lim
Publsiher: Elsevier Health Sciences
Total Pages: 229
Release: 2010-01-05
ISBN 10: 1455700452
ISBN 13: 9781455700455
Language: EN, FR, DE, ES & NL

Immunotherapy An Issue of Neurosurgery Clinics E Book Book Review:

For this issue, Dr. Michael Lim of Johns Hopkins and Dr. Isaac Yang of UCSF team up to deliver a packed issue on the latest developments in Immunotherapy. The issue covers hot topics such as immunostimulants, Passive Antibody Mediated Immunotherapy, Clinical Applications of A Peptide Based Vaccine, Challenges for Clinical Design of Immunotherapy Trials, The EGFRv3 Peptide Vaccine, Stem Cell Therapy and Dendritic Cell Vaccines, Dendritic Glioma Fusion Vaccine, Adoptive Cellular Immunotherapy, Virus Mediated Immunotherapy, and so much more.

The Duke Glioma Handbook

The Duke Glioma Handbook
Author: Allan H. Friedman
Publsiher: Cambridge University Press
Total Pages: 220
Release: 2016-03-31
ISBN 10: 1107065976
ISBN 13: 9781107065970
Language: EN, FR, DE, ES & NL

The Duke Glioma Handbook Book Review:

Provides a summary of glioma biology, genetics and management, based on the world-leading Duke University Preston Robert Tisch Brain Tumor Center program.

Brain Tumor Immunotherapy

Brain Tumor Immunotherapy
Author: Linda M. Liau,Donald P. Becker,Timothy F. Cloughesy,Darell D. Bigner
Publsiher: Springer Science & Business Media
Total Pages: 374
Release: 2000-11-10
ISBN 10: 1592590357
ISBN 13: 9781592590353
Language: EN, FR, DE, ES & NL

Brain Tumor Immunotherapy Book Review:

An authoritative panel of researchers and clinicians critically reviews the entire field to provide a comprehensive guide to modern brain tumor immunotherapy and thereby enhance future research in this area. The contributors detail many of the key laboratory experiments and clinical protocols that are currently being investigated, integrate the available information from previous and ongoing research, and help define the current status of the field. Topics range from adoptive cellular and antibody-mediated immunotherapy of brain tumors to tumor vaccines and related strategies, and include many vanguard experimental strategies and immunological techniques for studying brain tumor immunotherapy. Cutting-edge and comprehensive, Brain Tumor Immunotherapy brings together all the important recent advances in our understanding of central nervous system tumor immunology and illustrates in powerful detail the many new applications now harnessing the immune response for brain tumor therapeutics.

Gliomas

Gliomas
Author: Anonim
Publsiher: Academic Press
Total Pages: 464
Release: 2016-03-02
ISBN 10: 0128030070
ISBN 13: 9780128030073
Language: EN, FR, DE, ES & NL

Gliomas Book Review:

Researchers’ knowledge of gliomas continues to advance rapidly at both the basic and translational levels, and Gliomas provides a thorough overview of the evolving fields of tumor biology and clinical medicine as they relate to our understanding of brain tumors. Gliomas reviews the current paradigms that underlie these fields, beginning with the molecular epidemiology of glioma susceptibility and prognosis through population-based science and genome-wide association studies. The book’s discussion of imaging modalities extends beyond advances in anatomical imaging to include metabolic and physiological studies. This work provides thorough discussion of the clinical view of tumors, ranging from the presentation of the patient to surgical management, and covers all therapeutic options for patient care, including chemotherapy, targeted molecular therapies, immunotherapies, and even personalized approaches to impact the set of lesions. Additionally, the book discusses radiotherapy with regard to the many options available to treat patients using myriad fractionated techniques with various sources. Finally, Gliomas reviews issues specific to the quality of life for patients, and techniques for maximizing the effect of caregivers. Edited and authored by premier researchers from around the world, Gliomas is a comprehensive reference for clinicians and researchers seeking the most up-to-date information on gliomas, and a guide to the best ways to effectively manage glioma patients and their care. Synthesizes widely dispersed information on the management of gliomas into one comprehensive resource Chapters written by international authors who are preeminent researchers in the field Fully explores the therapeutic options for patient care, from chemotherapy to radiotherapy to personalized approaches

Malignant Gliomas RMR V3 I2

Malignant Gliomas  RMR V3 I2
Author: Anonim
Publsiher: Demos Medical Publishing
Total Pages: 252
Release: 2012-10-09
ISBN 10: 1617051489
ISBN 13: 9781617051487
Language: EN, FR, DE, ES & NL

Malignant Gliomas RMR V3 I2 Book Review:

Radiation Medicine Rounds is a trinary, hard cover periodical designed to provide an up-to-date review of a dedicated radiation medicine topic of interest to clinicians and scientists who are involved in the care of patients receiving radiotherapy. It is intended to serve as both a reference and instructional tool for students, housestaff, fellows, practicing clinicians, medical physicists, cancer biologists, radiobiologists, and interdisciplinary colleagues throughout the oncology spectrum. This issue of Radiation Medicine Rounds discusses the more salient topics surrounding the role of radiation therapy for malignant gliomas. The specialty of radiation therapy has increased in complexity over the years, yet as technology improves, the goal of improving outcomes while decreasing toxicity remains critical. Malignant gliomas remain among the most devastating of all malignancies, yet as conventional treatments (surgery, radiation, and chemotherapy) have become optimized overall survival has improved. The underlying molecular and genetic mechanisms of these tumors are becoming better understood, with one of the most important realizations being that histopathologically identical malignant gliomas often demonstrate very distinct clinical behaviors. Malignant Gliomas provides the practitioner with a current overview of best practices, recent research, and future directions in the management of this complex and challenging cancer.

Stem Cell Biology in Neoplasms of the Central Nervous System

Stem Cell Biology in Neoplasms of the Central Nervous System
Author: Moneeb Ehtesham
Publsiher: Springer
Total Pages: 190
Release: 2015-04-20
ISBN 10: 3319165372
ISBN 13: 9783319165370
Language: EN, FR, DE, ES & NL

Stem Cell Biology in Neoplasms of the Central Nervous System Book Review:

This volume presents the most current reviews on how cancer stem cells (CSCs) hypothesis dictates that the continued proliferation of a tumor is dependent on a sub-population of self-renewing and asymmetrically dividing neoplastic stem cells that supply a largely differentiated tumor. This volume provides a comprehensive overview of the characteristics of CSCs, their role in central nervous system (CNS) tumors, and the recent CSC-specific treatment modalities being used. The emerging focus on CSCs in brain tumors represents a paradigm shift in our understanding of the pathogenesis of these neoplasms. Importantly, the realization that a distinct sub-population of cells contributes disproportionately to the growth and sustenance of central nervous system tumors has important implications for the treatment of such tumors. To treat CNS tumors, there is now a growing need to treat CSCs to achieve adequate tumor control.

Brain Tumors

Brain Tumors
Author: Amit Agrawal,Luis Rafael Moscote-Salazar
Publsiher: BoD – Books on Demand
Total Pages: 248
Release: 2018-08-22
ISBN 10: 1789235561
ISBN 13: 9781789235562
Language: EN, FR, DE, ES & NL

Brain Tumors Book Review:

We all know that the field of neuro-oncology is heterogeneous and under continuous development with the addition of new knowledge and information on a regular basis. The present book "Brain Tumor - An Update" is an attempt to share the personal experiences of experts who are involved in neuro-oncology-related research. Through this book, the authors share their experiences and provide details about the pathophysiology, neuroimaging approaches, and management options, and how to go about decision-making in patients with brain tumors. We hope that the valuable contributions from the authors shall facilitate understanding about brain tumors. I am grateful to all the authors who have contributed their tremendous expertise, and I would like to acknowledge the outstanding support of Ms. Danijela Sakic, Author Service Manager, IntechOpen Science, who collaborated tirelessly in crafting this book.

Handbook of Brain Tumor Chemotherapy Molecular Therapeutics and Immunotherapy

Handbook of Brain Tumor Chemotherapy  Molecular Therapeutics  and Immunotherapy
Author: Herbert B. Newton
Publsiher: Academic Press
Total Pages: 848
Release: 2018-03-28
ISBN 10: 0128121017
ISBN 13: 9780128121016
Language: EN, FR, DE, ES & NL

Handbook of Brain Tumor Chemotherapy Molecular Therapeutics and Immunotherapy Book Review:

Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy, Second Edition, provides a comprehensive overview of the molecular methodologies in the neuro-oncology field. There have been profound changes in the landscape of approaches to brain tumor therapy since the first edition—mainly in the areas of molecular biology and molecular therapeutics, as well as in the maturation of immunotherapy approaches (e.g., vaccines). This updated edition has a new, primary focus on multidisciplinary molecular methods, and is broadened to include the latest cutting-edge molecular biology, therapeutics, immunobiology and immunotherapy approaches. As the first comprehensive book to address the molecular research into these concepts, users will find it to be an invaluable resource on the topics discussed. Provides the most up-to-date information regarding conventional forms of cytotoxic chemotherapy, as well as the basic science and clinical application of molecular therapeutics for the treatment of brain tumors Broadly appeals to anyone interested in neuro-oncology and the treatment of brain tumors Features updated chapters on molecular biology, molecular therapeutics, maturation of immunotherapy approaches, and a focus on multidisciplinary molecular methods Includes a new section on the basic science of immunology, as well as thorough updates on the use of vaccine technology and immunotherapy for the treatment of brain tumors

Advances in Veterinary Neurology An Issue of Veterinary Clinics of North America Small Animal Practice

Advances in Veterinary Neurology  An Issue of Veterinary Clinics of North America  Small Animal Practice
Author: Natasha J. Olby
Publsiher: Elsevier Health Sciences
Total Pages: 273
Release: 2014-11-12
ISBN 10: 0323326919
ISBN 13: 9780323326919
Language: EN, FR, DE, ES & NL

Advances in Veterinary Neurology An Issue of Veterinary Clinics of North America Small Animal Practice Book Review:

This issue highlights the advances in neurological treatments for dogs and cats. Articles include: New Treatment Modalities for Brain Tumors in Dogs and Cats, Altered Mental Status in Dogs and Cats: Stupor and Coma, Steroid Use in Veterinary Neurology, Hereditary Ataxia and Paroxysmal Movement Disorders in Dogs and Cats, Paroxysmal Movement Disorders in Dogs and Cats, Cluster Seizures and Status Epilepticus, Aging in the canine and feline brain, Acute Spinal Cord Injury: Tetraparesis and Paraparesis, Meningoencephalitis of Unknown Etiology, and more!

Molecular Considerations and Evolving Surgical Management Issues in the Treatment of Patients with a Brain Tumor

Molecular Considerations and Evolving Surgical Management Issues in the Treatment of Patients with a Brain Tumor
Author: Terry Lichtor
Publsiher: BoD – Books on Demand
Total Pages: 434
Release: 2015-03-25
ISBN 10: 953512031X
ISBN 13: 9789535120315
Language: EN, FR, DE, ES & NL

Molecular Considerations and Evolving Surgical Management Issues in the Treatment of Patients with a Brain Tumor Book Review:

A dramatic increase in knowledge regarding the molecular biology of brain tumors has been established over the past few years. In particular, recent new avenues regarding the role of microRNAs along with further understanding of the importance of angiogenesis, immunotherapy and explanations for the resistance of the tumors to radiation therapy have been developed. A discussion of certain surgical management issues including improvements in imaging along with issues concerning tumor induced epilepsy is included. It is hopeful that this new information will lead to efficacious treatment strategies for these tumors which remain a challenge. In this book, a review of the latest information on these topics along with a variety of new therapeutic treatment strategies with an emphasis on molecular targeted therapies is provided.

Brain Tumors E Book

Brain Tumors E Book
Author: Andrew H. Kaye,Edward R. Laws Jr
Publsiher: Elsevier Health Sciences
Total Pages: 1088
Release: 2011-12-06
ISBN 10: 0702048186
ISBN 13: 9780702048180
Language: EN, FR, DE, ES & NL

Brain Tumors E Book Book Review:

Meet the increasing need for effective brain tumor management with the highly anticipated revision of Brain Tumors by Drs. Andrew H. Kaye and Edward R. Laws. Over the past decade, enormous advances have been made in both the diagnosis and the surgical and radiotherapeutic management of brain tumors. This new edition guides you through the latest developments in the field, including hot topics like malignant gliomas, functional brain mapping, neurogenetics and the molecular biology of brain tumors, and biologic and gene therapy. Benefit from the knowledge and experience of Drs. Andrew H. Kaye and Edward R. Laws, globally recognized experts in the field of neurosurgery, as well as many other world authorities.

Central Nervous System Cancers

Central Nervous System Cancers
Author: Oncology Nursing Society
Publsiher: Anonim
Total Pages: 151
Release: 2011
ISBN 10: 9781890504984
ISBN 13: 189050498X
Language: EN, FR, DE, ES & NL

Central Nervous System Cancers Book Review:

Considered one of the most devastating and frightening of all cancers, cancers of the central nervous system (CNS) attack the complex organs that control not only the CNS but also the peripheral nervous system and many of the voluntary and involuntary body systems, with 20% to 40% of CNS cancers metastasizing to the brain. Site-Specific Cancer Series: Central Nervous System Cancers, a new volume in the Series edited by Deborah Hutchinson Allen and Laurie L. Rice, details the cancers of the brain and spinal cord. Chapters examine issues such as anatomy and physiology of the brain and spine, patient assessment, pathology, histology, and molecular markers of primary brain tumors, and adult and pediatric cancers of the brain and spinal cord. Other issues include treatment modalities (surgical treatments, chemotherapy, and radiotherapy), as well as pediatric therapeutic modalities, symptom management and psychological issues, and the current state of evidence-based practice. You can use this new volume as a guide to treating your patients and to providing sensitive and realistic care that optimizes the quality of life and permits a sense of hopefulness to prevail when many patients with type of cancer feel only pain and fear.

Gliomas New Insights for the Healthcare Professional 2011 Edition

Gliomas  New Insights for the Healthcare Professional  2011 Edition
Author: Anonim
Publsiher: ScholarlyEditions
Total Pages: 175
Release: 2012-01-09
ISBN 10: 1464901406
ISBN 13: 9781464901409
Language: EN, FR, DE, ES & NL

Gliomas New Insights for the Healthcare Professional 2011 Edition Book Review:

Gliomas: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Gliomas. The editors have built Gliomas: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Gliomas in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Gliomas: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.