Immunotherapeutic Strategies for the Treatment of Glioma

Immunotherapeutic Strategies for the Treatment of Glioma
Author: Christopher Jackson,Michael Lim
Publsiher: Elsevier
Total Pages: 190
Release: 2021-09-27
ISBN 10: 0128197552
ISBN 13: 9780128197554
Language: EN, FR, DE, ES & NL

Immunotherapeutic Strategies for the Treatment of Glioma Book Review:

Immunotherapeutic Strategies for the Treatment of Glioma provides a review of the current state of immunotherapy for primary brain tumors. The topic is of interest to patients, clinicians, and researchers alike, particularly given the recent failure of large clinical trials. This book serves as an overview of the most promising approaches in the field and provides a foundation for considering novel and combination therapies moving forward. The book discusses several types of immunotherapies for glioma, such as peptide, dendritic cell and heat shock protein vaccines; immune checkpoint blockade; myeloid cells as target; oncolytic viruses; and CAR T cell therapy. Additionally, it discusses the mechanisms of immune suppression in patients and immunogenomics. This volume is a valuable source for cancer researchers, oncologists and several members of biomedical field who are interested in novel strategies to fight glioblastoma. Summarizes the work in immunotherapy for glioma to-date, including the available evidence from preclinical studies and clinical trials Reviews the challenges and successes of the most promising strategies for brain tumor immunotherapy Provides a foundation for considering novel and combination therapies moving forward

Glioma

Glioma
Author: ryuya yamanaka
Publsiher: Springer Science & Business Media
Total Pages: 232
Release: 2012-05-27
ISBN 10: 1461431468
ISBN 13: 9781461431466
Language: EN, FR, DE, ES & NL

Glioma Book Review:

Treatment of glioma is currently one of the most challenging problems in oncology, as well as in neurosurgery. Despite major advances in our understanding of the pathomechanism, diagnosis by imaging and the availability of powerful therapeutic tools, the life expectancy of patients with glioblastoma has only been slightly prolonged and a cure remains elusive. None of the currently available surgical tools, including operative microscopes, lasers and image-guided surgery, can enable the detection and removal of all of the tumor tissue. In recent years, however, the landscape has been changing immeasurably, and molecular studies over the past two decades have identified a variety of genetic aberrations that are specifically associated with individual types of gliomas. In addition, certain molecular abnormalities have been linked to therapy responses, thereby establishing clinical biomarkers and molecular targets, and the use of novel agents is being investigated. These agents have been specifically engineered to exert specific cytotoxicity against gliomas, either on their own as single agents or in combination with other modalities. Moreover, there has been an enormous surge of interest in the area of immunology and immunotherapy, which has been facilitated by our understanding of the molecular basis of gliomas. Although several kinds of immunotherapeutic trials have been undertaken, we still await a great breakthrough in terms of clinical efficacy to prolong the survival time of glioma patients.

The Duke Glioma Handbook

The Duke Glioma Handbook
Author: Allan H. Friedman
Publsiher: Cambridge University Press
Total Pages: 220
Release: 2016-03-31
ISBN 10: 1107065976
ISBN 13: 9781107065970
Language: EN, FR, DE, ES & NL

The Duke Glioma Handbook Book Review:

Provides a summary of glioma biology, genetics and management, based on the world-leading Duke University Preston Robert Tisch Brain Tumor Center program.

Immunotherapeutic Strategies for the Treatment of Glioma

Immunotherapeutic Strategies for the Treatment of Glioma
Author: Christopher Jackson,Michael Lim
Publsiher: Academic Press
Total Pages: 190
Release: 2021-09-23
ISBN 10: 0128197560
ISBN 13: 9780128197561
Language: EN, FR, DE, ES & NL

Immunotherapeutic Strategies for the Treatment of Glioma Book Review:

Immunotherapeutic Strategies for the Treatment of Glioma provides a review of the current state of immunotherapy for primary brain tumors. The topic is of interest to patients, clinicians, and researchers alike, particularly given the recent failure of large clinical trials. This book serves as an overview of the most promising approaches in the field and provides a foundation for considering novel and combination therapies moving forward. The book discusses several types of immunotherapies for glioma, such as peptide, dendritic cell and heat shock protein vaccines; immune checkpoint blockade; myeloid cells as target; oncolytic viruses; and CAR T cell therapy. Additionally, it discusses the mechanisms of immune suppression in patients and immunogenomics. This volume is a valuable source for cancer researchers, oncologists and several members of biomedical field who are interested in novel strategies to fight glioblastoma. Summarizes the work in immunotherapy for glioma to-date, including the available evidence from preclinical studies and clinical trials Reviews the challenges and successes of the most promising strategies for brain tumor immunotherapy Provides a foundation for considering novel and combination therapies moving forward

Glioblastoma

Glioblastoma
Author: Swapan K. Ray
Publsiher: Springer Science & Business Media
Total Pages: 431
Release: 2009-10-31
ISBN 10: 9781441904102
ISBN 13: 1441904107
Language: EN, FR, DE, ES & NL

Glioblastoma Book Review:

Glioblastoma is the most malignant brain tumor that still remains incurable. It is such a deadly disease that patients do not survive more than a few months after diagnosis. Our understanding of the histopathology and molecular mechanisms of formation of glioblastoma is rapidly advancing so as to provide us clues for devising rational therapeutic strategies for treatment of this malignancy. It is important that we continue to improve our knowledge about the pathogenesis of this devastating disease and explore new areas to find successful therapeutic strategies. Various approaches such as sophisticated imaging techniques, improved surgical procedures, ground-breaking strategies for radiotherapy, chemotherapy, immunotherapy, chemoimmunotherapy, and photodynamic therapy are being used for eradicating glioblastoma. Hopefully, this book will be an important source of information on glioblastoma and therefore be highly useful to the students, postdoctoral fellows, principal investigators, and clinicians involved in this field.

Impact of Immunotherapy in the Treatment of Glioblastoma

Impact of Immunotherapy in the Treatment of Glioblastoma
Author: Jessica Silva
Publsiher: Unknown
Total Pages: 135
Release: 2018
ISBN 10: 1928374650XXX
ISBN 13: OCLC:1154234821
Language: EN, FR, DE, ES & NL

Impact of Immunotherapy in the Treatment of Glioblastoma Book Review:

Glioblastoma multiforme (GBM) is the most common and aggressive primary malignant brain tumor. Despite the efforts developed in the respective treatment, consisting of maximal surgical resection followed by adjuvant radiotherapy and chemotherapy, the prognosis remains very poor. This may be partly related to the resistance of GBM cells and their infiltrative and invasive nature into the surrounding brain tissue. Therefore, newer and challenging alternative approaches for the treatment have emerged, including immunotherapy. This anticancer therapy, based on the stimulation of the host's immune system, has been currently investigated and several advances in the clinical trial stage have already been reached. Immunotherapeutic strategies comprise a set of modalities, including vaccines (cell-free and cell-based), chimeric antigen receptor (CAR) T-cell therapy, immune checkpoint inhibitors, monoclonal antibodies (mAbs), and oncolytic viruses (OVs). In this chapter, we will review the principal concepts and the recent progress in immunotherapy for GBM.

Brain Tumor Immunotherapy

Brain Tumor Immunotherapy
Author: Linda M. Liau,Donald P. Becker,Timothy F. Cloughesy,Darell D. Bigner
Publsiher: Springer Science & Business Media
Total Pages: 374
Release: 2000-11-10
ISBN 10: 1592590357
ISBN 13: 9781592590353
Language: EN, FR, DE, ES & NL

Brain Tumor Immunotherapy Book Review:

An authoritative panel of researchers and clinicians critically reviews the entire field to provide a comprehensive guide to modern brain tumor immunotherapy and thereby enhance future research in this area. The contributors detail many of the key laboratory experiments and clinical protocols that are currently being investigated, integrate the available information from previous and ongoing research, and help define the current status of the field. Topics range from adoptive cellular and antibody-mediated immunotherapy of brain tumors to tumor vaccines and related strategies, and include many vanguard experimental strategies and immunological techniques for studying brain tumor immunotherapy. Cutting-edge and comprehensive, Brain Tumor Immunotherapy brings together all the important recent advances in our understanding of central nervous system tumor immunology and illustrates in powerful detail the many new applications now harnessing the immune response for brain tumor therapeutics.

Intracranial Gliomas Part III Innovative Treatment Modalities

Intracranial Gliomas Part III   Innovative Treatment Modalities
Author: M.F. Chernov,Y. Muragaki,S. Kesari,I.E. McCutcheon
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 222
Release: 2018-07-10
ISBN 10: 3318060631
ISBN 13: 9783318060638
Language: EN, FR, DE, ES & NL

Intracranial Gliomas Part III Innovative Treatment Modalities Book Review:

At present most intracranial gliomas are considered incurable with current treatment strategies, and the search for new modalities that may effectively control tumor growth continues. The chapters in this volume describe basic principles and therapeutic possibilities of several innovative techniques, including photodynamic therapy, laser-induced interstitial thermotherapy, stereotactic cryodestruction, high-intensity focused ultrasound ablation, boron neutron capture therapy, proton and carbon ion irradiation, targeted therapy, immunotherapy, gene therapy, local chemotherapy, and alternating electric fields therapy. Potential applications of extracellular vesicles and nanotechnology for management of gliomas are highlighted as well. Many of these methods have already demonstrated antitumor efficacy in clinical testing, whereas others are still under development. The materials presented in this book are mainly directed at clinicians treating patients with brain tumors, as well as clinical and basic researchers working in the field of neuro-oncology.

New Techniques for Management of Inoperable Gliomas

New Techniques for Management of    Inoperable    Gliomas
Author: Michael E. Sughrue,Isaac Yang
Publsiher: Academic Press
Total Pages: 256
Release: 2019-08-03
ISBN 10: 0128136340
ISBN 13: 9780128136348
Language: EN, FR, DE, ES & NL

New Techniques for Management of Inoperable Gliomas Book Review:

New Techniques for Management of 'Inoperable' Gliomas radically challenges the assumption that certain gliomas cannot be removed with modern techniques, contesting stereotypical thinking and establishing new paradigms in the field. Gliomas are primary brain tumors which are often fatal. Recent data has demonstrated that despite the fact that surgery cannot cure gliomas, patient survival is substantially improved by removing as much of the tumor as possible. This fact has raised the imperative that neurologists try to improve techniques to bring surgical resection to as many patients as possible. This book brings new insights and technologies to the forefront, giving hope to patients. Provides the first comprehensive book to discuss techniques for removing gliomas that are traditionally deemed ‘inoperable’ Presents a great reference tool that challenges stereotypical thinking by offering techniques by innovative surgeons Includes chapters that are organized by different glioma types and surgery/techniques

Neurosurgical Procedures

Neurosurgical Procedures
Author: Alba Scerrati,Pasquale De Bonis
Publsiher: BoD – Books on Demand
Total Pages: 146
Release: 2020-04-22
ISBN 10: 1789859271
ISBN 13: 9781789859270
Language: EN, FR, DE, ES & NL

Neurosurgical Procedures Book Review:

In the last few years, the development of new technologies in the medical field has allowed procedures and improved surgical techniques to be performed, which until recently would have been unthinkable.Modern neurosurgery is forever tied to technological progress: the development of robotics and robotic-assisted surgery; enhanced visualization, perfusion, and function monitoring in vascular surgery; new techniques of bone reconstruction; new cerebral imaging tools; and alternative treatments such as laser interstitial thermal therapy or immunotherapy for tumors. This book is designed to be a comprehensive introduction to these new developments and to their application in clinical practice. We have tried to provide a unique background and insights to coherently present these new technologies.

Re Irradiation New Frontiers

Re Irradiation  New Frontiers
Author: Carsten Nieder,Johannes Langendijk
Publsiher: Springer
Total Pages: 364
Release: 2016-10-25
ISBN 10: 3319418254
ISBN 13: 9783319418254
Language: EN, FR, DE, ES & NL

Re Irradiation New Frontiers Book Review:

This book, now in its second edition, provides a comprehensive overview of current re-irradiation strategies, with detailed discussion of re-irradiation methods, technical aspects, the role of combined therapy with anticancer drugs and hyperthermia, and normal tissue tolerance. In addition, disease specific chapters document recent clinical results and future research directions. All chapters from the first edition have been revised and updated to take account of the latest developments and research findings, including those from prospective studies. Due attention is paid to the exciting developments in the fields of proton irradiation and frameless image-guided ablative radiotherapy. The book documents fully how refined combined modality approaches and significant technical advances in radiation treatment planning and delivery have facilitated the re-irradiation of previously exposed volumes, allowing both palliative and curative approaches to be pursued at various disease sites. Professionals involved in radiation treatment planning and multimodal oncology treatment will find it to be an invaluable aid in understanding the benefits and limitations of re-irradiation and in designing prospective trials.

Current Understanding and Treatment of Gliomas

Current Understanding and Treatment of Gliomas
Author: Jeffrey Raizer,Andrew Parsa
Publsiher: Springer
Total Pages: 184
Release: 2014-12-02
ISBN 10: 3319120484
ISBN 13: 9783319120485
Language: EN, FR, DE, ES & NL

Current Understanding and Treatment of Gliomas Book Review:

This book reviews the significant advances in our understanding of glioma biology that have been achieved during the past decade and describes in detail the resultant new approaches to treatment. Improvements in surgical techniques, radiation therapy, and chemotherapy are comprehensively covered, with discussion of their impact in decreasing patient morbidity and increasing survival. In addition, individual chapters are devoted specifically to current treatment for low-grade gliomas, anaplastic gliomas, and glioblastoma multiforme. Other topics addressed include treatment of the elderly patient, investigating emerging therapies from small molecules to immunotherapy and palliative care. This timely book will be a valuable source of up-to-date information for practitioners and will also be of interest to researchers.

Handbook of Brain Tumor Chemotherapy Molecular Therapeutics and Immunotherapy

Handbook of Brain Tumor Chemotherapy  Molecular Therapeutics  and Immunotherapy
Author: Herbert B. Newton
Publsiher: Academic Press
Total Pages: 848
Release: 2018-03-28
ISBN 10: 0128121017
ISBN 13: 9780128121016
Language: EN, FR, DE, ES & NL

Handbook of Brain Tumor Chemotherapy Molecular Therapeutics and Immunotherapy Book Review:

Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy, Second Edition, provides a comprehensive overview of the molecular methodologies in the neuro-oncology field. There have been profound changes in the landscape of approaches to brain tumor therapy since the first edition—mainly in the areas of molecular biology and molecular therapeutics, as well as in the maturation of immunotherapy approaches (e.g., vaccines). This updated edition has a new, primary focus on multidisciplinary molecular methods, and is broadened to include the latest cutting-edge molecular biology, therapeutics, immunobiology and immunotherapy approaches. As the first comprehensive book to address the molecular research into these concepts, users will find it to be an invaluable resource on the topics discussed. Provides the most up-to-date information regarding conventional forms of cytotoxic chemotherapy, as well as the basic science and clinical application of molecular therapeutics for the treatment of brain tumors Broadly appeals to anyone interested in neuro-oncology and the treatment of brain tumors Features updated chapters on molecular biology, molecular therapeutics, maturation of immunotherapy approaches, and a focus on multidisciplinary molecular methods Includes a new section on the basic science of immunology, as well as thorough updates on the use of vaccine technology and immunotherapy for the treatment of brain tumors

Frontiers in Clinical Drug Research Anti Cancer Agents Volume 7

Frontiers in Clinical Drug Research   Anti Cancer Agents  Volume 7
Author: Atta-ur-Rahman
Publsiher: Bentham Science Publishers
Total Pages: 223
Release: 2021-07-07
ISBN 10: 1681087766
ISBN 13: 9781681087764
Language: EN, FR, DE, ES & NL

Frontiers in Clinical Drug Research Anti Cancer Agents Volume 7 Book Review:

Frontiers in Clinical Drug Research - Anti-Cancer Agents is a book series intended for pharmaceutical scientists, postgraduate students and researchers seeking updated and critical information for developing clinical trials and devising research plans in anti-cancer research. Reviews in each volume are written by experts in medical oncology and clinical trials research and compile the latest information available on special topics of interest to oncology and pharmaceutical chemistry researchers. The seventh volume of the book features reviews on these topics: · Essential oils and monoterpenes as potential anti-cancer agents · Drug delivery systems and emerging immunotherapeutic strategies for the treatment of glioblastoma · CTDNA in solid tumors · Cholesterol treatments (including Pitavastatin) and their potential in cancer treatment

Brain Tumors

Brain Tumors
Author: Amit Agrawal,Luis Rafael Moscote-Salazar
Publsiher: BoD – Books on Demand
Total Pages: 248
Release: 2018-08-22
ISBN 10: 1789235561
ISBN 13: 9781789235562
Language: EN, FR, DE, ES & NL

Brain Tumors Book Review:

We all know that the field of neuro-oncology is heterogeneous and under continuous development with the addition of new knowledge and information on a regular basis. The present book "Brain Tumor - An Update" is an attempt to share the personal experiences of experts who are involved in neuro-oncology-related research. Through this book, the authors share their experiences and provide details about the pathophysiology, neuroimaging approaches, and management options, and how to go about decision-making in patients with brain tumors. We hope that the valuable contributions from the authors shall facilitate understanding about brain tumors. I am grateful to all the authors who have contributed their tremendous expertise, and I would like to acknowledge the outstanding support of Ms. Danijela Sakic, Author Service Manager, IntechOpen Science, who collaborated tirelessly in crafting this book.

Glioma

Glioma
Author: Ibrahim Omerhodzic,Kenan Arnautovic
Publsiher: BoD – Books on Demand
Total Pages: 258
Release: 2019-01-16
ISBN 10: 1789849535
ISBN 13: 9781789849530
Language: EN, FR, DE, ES & NL

Glioma Book Review:

The past three decades have been marked with huge enthusiasm from scientists and professionals in an effort to find a cure for glioma disease. Methods to confirm the kinds and grades of glioma have taken a path from classical macro- to microscopic pathohystological confirmation of tumors, through morphological-histological, molecular, and genetic diagnosis. Surgically, progress was made possible with the development and use of technological aids, for example neuronavigation, cortical mapping, electrocorticography, neuromonitoring, functional and intraoperative MRI, magnetoencephalography, etc. Great hope was placed on the extension of tumor resection and popular supratotal resection. Significant progress has been made generally in glioma treatment with the use of modern radiotherapy and new chemotherapeutics. What do we want to see for the future? By way of stem cells, a specific medicine will be produced, individualized for the particular patient, and by using a microcapsule it will be implanted into the brain zone affected by the tumor by way of robot surgery and injection needle. This is not at all an unrealistic expectation in the next decade or two.

Cancer Vaccines

Cancer Vaccines
Author: Adrian Bot,Mihail Obrocea,Francesco M. Marincola
Publsiher: CRC Press
Total Pages: 280
Release: 2015-05-06
ISBN 10: 1841848301
ISBN 13: 9781841848303
Language: EN, FR, DE, ES & NL

Cancer Vaccines Book Review:

Recent advances in immunology and biology have opened new horizons in cancer therapy, included in the expanding array of cancer treatment options, which are immunotherapies, or cancer vaccines, for both solid and blood borne cancers. Cancer Vaccines: From Research to Clinical Practice is the first text in the field to bring immunotherapy treatments from the laboratory trial to the bedside for the practicing oncologist. Cancer Vaccines: From Research to Clinical Practice: Analyzes the most promising classes of investigational immunotherapies, integrating their scientific rationale and clinical potential Discusses "theranostics" as pertaining to immunotherapy, i.e., using molecular diagnostics to identify patients that would most likely benefit from a therapy Presents the new paradigm of biomarker guided R&D and clinical development in immunotherapy of cancer Reviews bottlenecks in translational process of immunotherapies and offers strategies to resolve them

Neuroblastoma

Neuroblastoma
Author: Swapan K. Ray
Publsiher: Academic Press
Total Pages: 334
Release: 2019-01-11
ISBN 10: 0128120045
ISBN 13: 9780128120040
Language: EN, FR, DE, ES & NL

Neuroblastoma Book Review:

Neuroblastoma: Molecular Mechanisms and Therapeutic Interventions comprehensively reviews current concepts in molecular and histopathological mechanisms that influence the growth of human malignant neuroblastoma, along with exciting therapeutic interventions. This book features a broad collection of contributions from leading investigators in histopathology, molecular mechanisms, genetics, epigenetics, microRNAs, proteomics, and metabolism in controlling growth and death in neuroblastoma. Recent developments in therapeutic interventions for neuroblastoma are also covered extensively, including chapters on surgery, chemotherapy, targeted therapy and immunotherapy. This book is ideal for advanced undergraduate students, graduate students, medical students, postdoctoral fellows, and investigators with an interest in current molecular concepts and therapeutic interventions. Comprehensively covers the histopathological characterization, molecular mechanisms, and most recent therapeutic interventions in neuroblastoma Includes recent developments and therapeutic interventions for neuroblastoma, including chapters on surgery, chemotherapy, targeted therapy and immunotherapy Presents a broad scope that provides basic researchers, practitioners and students with the most current overview of recent advances

New Approaches to the Management of Primary and Secondary CNS Tumors

New Approaches to the Management of Primary and Secondary CNS Tumors
Author: Lee Roy Morgan
Publsiher: BoD – Books on Demand
Total Pages: 214
Release: 2017-03-23
ISBN 10: 953513051X
ISBN 13: 9789535130512
Language: EN, FR, DE, ES & NL

New Approaches to the Management of Primary and Secondary CNS Tumors Book Review:

Several new concepts are reviewed and discussed in this book and allude to the transport of drugs bound to red blood cells into the vascular blood-brain barrier and into cancer cells. Such a transport system is novel and of potential therapeutic potential. It is the goal of this book to provide information and data that will be useful for others to develop new approaches for the management of CNS malignancies.

Gliomas

Gliomas
Author: Anonim
Publsiher: Academic Press
Total Pages: 464
Release: 2016-03-02
ISBN 10: 0128030070
ISBN 13: 9780128030073
Language: EN, FR, DE, ES & NL

Gliomas Book Review:

Researchers’ knowledge of gliomas continues to advance rapidly at both the basic and translational levels, and Gliomas provides a thorough overview of the evolving fields of tumor biology and clinical medicine as they relate to our understanding of brain tumors. Gliomas reviews the current paradigms that underlie these fields, beginning with the molecular epidemiology of glioma susceptibility and prognosis through population-based science and genome-wide association studies. The book’s discussion of imaging modalities extends beyond advances in anatomical imaging to include metabolic and physiological studies. This work provides thorough discussion of the clinical view of tumors, ranging from the presentation of the patient to surgical management, and covers all therapeutic options for patient care, including chemotherapy, targeted molecular therapies, immunotherapies, and even personalized approaches to impact the set of lesions. Additionally, the book discusses radiotherapy with regard to the many options available to treat patients using myriad fractionated techniques with various sources. Finally, Gliomas reviews issues specific to the quality of life for patients, and techniques for maximizing the effect of caregivers. Edited and authored by premier researchers from around the world, Gliomas is a comprehensive reference for clinicians and researchers seeking the most up-to-date information on gliomas, and a guide to the best ways to effectively manage glioma patients and their care. Synthesizes widely dispersed information on the management of gliomas into one comprehensive resource Chapters written by international authors who are preeminent researchers in the field Fully explores the therapeutic options for patient care, from chemotherapy to radiotherapy to personalized approaches