Immunoinformatics

Immunoinformatics
Author: Christian Schönbach,Shoba Ranganathan,Vladimir Brusic
Publsiher: Springer Science & Business Media
Total Pages: 200
Release: 2007-11-21
ISBN 10: 0387729682
ISBN 13: 9780387729688
Language: EN, FR, DE, ES & NL

Immunoinformatics Book Review:

In contrast to existing books on immunoinformatics, this volume presents a cross-section of immunoinformatics research. The contributions highlight the interdisciplinary nature of the field and how collaborative efforts among bioinformaticians and bench scientists result in innovative strategies for understanding the immune system. Immunoinformatics is ideal for scientists and students in immunology, bioinformatics, microbiology, and many other disciplines.

Immunoinformatics

Immunoinformatics
Author: Darren R. Flower
Publsiher: Springer Science & Business Media
Total Pages: 438
Release: 2007-06-21
ISBN 10: 1588296997
ISBN 13: 9781588296993
Language: EN, FR, DE, ES & NL

Immunoinformatics Book Review:

This volume both engages the reader and provides a sound foundation for the use of immunoinformatics techniques in immunology and vaccinology. It addresses databases, HLA supertypes, MCH binding, and other properties of immune systems. The book contains chapters written by leaders in the field and provides a firm background for anyone working in immunoinformatics in one easy-to-use, insightful volume.

Immunoinformatics

Immunoinformatics
Author: Gregory R. Bock,Jamie A. Goode
Publsiher: John Wiley & Sons
Total Pages: 272
Release: 2004-03-05
ISBN 10: 0470090758
ISBN 13: 9780470090756
Language: EN, FR, DE, ES & NL

Immunoinformatics Book Review:

The astounding diversity of the immune system and the complexity of its regulatory pathways makes immunology a combinatorial science. Computational analysis has therefore become an essential element of immunology research and this has led to the creation of the emerging field of immunoinformatics. This book is the first to feature thorough coverage of this new field. Immunoinformatics facilitates the understanding of immune function by modelling the interactions among immunological components. Biological research provides ever deeper insights into the complexity of living organisms while computer science provides an effective means to store and analyse large volumes of complex data. Combining the two fields increases the efficiency of biological research and offers the potential for major advances in the study of biological systems. This book encompasses key developments in immunoinformatics, including immunological databases, sequence analysis, structure modelling, mathematical modelling of the immune system, simulation of laboratory experiments, statistical support for immunological experimentation and immunogenomics. The difficulties in effective application of bioinformatic tools in immunology arise at both ends of the spectrum: most immunologists have only a limited comprehension of sophisticated data analysis and applicability and limitations, while the average computer scientist lacks knowledge of the depth and complexity of biological data. The purpose of this book, therefore, is to present contributions from a multidisciplinary team of biologists and computer scientists to explore the issues related to better understanding of immune function and, in particular, to help apply new computer science methods to immunological research. Related Novartis Foundation symposia: 247 In Silico Simulation of Biological Processes Chair: Denis Noble 252 Generation and effector functions of regulatory lymphocytes Chair: Jean-François Bach

Immunoinformatics

Immunoinformatics
Author: Namrata Tomar
Publsiher: Humana
Total Pages: 410
Release: 2020-04-24
ISBN 10: 9781071603888
ISBN 13: 1071603884
Language: EN, FR, DE, ES & NL

Immunoinformatics Book Review:

This book covers a wide range of diverse immunoinformatics research topics, involving tools and databases of potential epitope prediction, HLA gene analysis, MHC characterizing, in silico vaccine design, mathematical modeling of host-pathogen interactions, and network analysis of immune system data. In that way, this fully updated volume explores the enormous value of computational tools and models in immunology research. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of key insights and detailed implementation advice to encourage successful results in the lab. Authoritative and practical, Immunoinformatics, Third Edition serves as an ideal guide for scientists working at the intersection of bioinformatics, mathematical modelling, and statistics for the study of immune systems biology.

Cancer Immunology

Cancer Immunology
Author: Nima Rezaei
Publsiher: Springer
Total Pages: 488
Release: 2015-04-24
ISBN 10: 3662464101
ISBN 13: 9783662464106
Language: EN, FR, DE, ES & NL

Cancer Immunology Book Review:

Cancer Immunology is intended as an up-to-date, clinically relevant review of cancer immunology and immunotherapy. This volume focuses on the immunopathology and immunotherapy of organ cancers in detail. It clearly explains their immunology and describes novel immunotherapy for specific cancers, including pediatric solid tumors, hematologic malignancies, gastrointestinal tumors, skin cancers, bone and connective tissue tumors, central nervous system tumors, lung cancers, genitourinary tract tumors and breast cancers. In so doing, it builds on the previous two volumes in Cancer Immunology, placing basic knowledge on tumor immunology and immunotherapy into a clinical perspective with the aim of educating clinicians on advances in cancer immunology and the most recent approaches in the immunotherapy of various tumors. This translational, clinically oriented book will be of special value to clinical immunologists, hematologists and oncologists.

Immunotherapy of Cancer

Immunotherapy of Cancer
Author: Mary L. Disis
Publsiher: Springer Science & Business Media
Total Pages: 516
Release: 2005-12-15
ISBN 10: 1588295648
ISBN 13: 9781588295644
Language: EN, FR, DE, ES & NL

Immunotherapy of Cancer Book Review:

Expert bench and clinical scientists join forces to concurrently review both the state-of-the-art in tumor immunology and its clinical translation into promising practical treatments. The authors explain in each chapter the scientific basis behind such therapeutic agents as monoclonal antibodies, cytokines, vaccines, and T-cells, and illustrate their clinical manipulation to combat cancer. Additional chapters address statistical analysis-both of clinical trials and assay evaluations-methods for the discovery of antigens, adoptive T cell therapy, and adaptive and innate immunity. The challenges in clinical trial design, the need for biomarkers of response-such as novel imaging techniques and immunologic monitoring-and the new advances and directions in cancer immunotherapy are also fully examined.

Lymphoma Vaccines: New Insights for the Healthcare Professional: 2012 Edition

Lymphoma Vaccines: New Insights for the Healthcare Professional: 2012 Edition
Author: Anonim
Publsiher: ScholarlyEditions
Total Pages: 22
Release: 2012-12-10
ISBN 10: 1464982872
ISBN 13: 9781464982873
Language: EN, FR, DE, ES & NL

Lymphoma Vaccines: New Insights for the Healthcare Professional: 2012 Edition Book Review:

Lymphoma Vaccines: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Lymphoma Vaccines in a compact format. The editors have built Lymphoma Vaccines: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Lymphoma Vaccines in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Lymphoma Vaccines: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

In Silico Immunology

In Silico Immunology
Author: Darren D.R. Flower,Jon Timmis
Publsiher: Springer Science & Business Media
Total Pages: 451
Release: 2007-04-16
ISBN 10: 0387392416
ISBN 13: 9780387392417
Language: EN, FR, DE, ES & NL

In Silico Immunology Book Review:

This book outlines three emergent disciplines, which are now poised to engineer a paradigm shift from hypothesis- to data-driven research: theoretical immunology, immunoinformatics, and Artificial Immune Systems. It details how these disciplines will enable new understanding to emerge from the analysis of complex datasets. Coverage shows how these three are set to transform immunological science and the future of health care.

Precision Molecular Pathology of Breast Cancer

Precision Molecular Pathology of Breast Cancer
Author: Ashraf Khan,Ian O. Ellis,Andrew M. Hanby,Ediz F. Cosar,Emad A. Rakha,Dina Kandil
Publsiher: Springer
Total Pages: 338
Release: 2015-08-12
ISBN 10: 1493928864
ISBN 13: 9781493928866
Language: EN, FR, DE, ES & NL

Precision Molecular Pathology of Breast Cancer Book Review:

This volume provides a comprehensive review of the molecular mechanisms involved in precancerous lesions and benign and malignant breast tumors. Given the complex molecular pathways in breast cancer biology, the book simplifies these complex mechanisms and highlights the practical issues important for daily practice. Sections are structured to review breast carcinogenesis and the role of familial predisposition and stem cells in initiation and progression of breast cancer. In-depth chapters present morphologic and molecular correlations in precancerous and malignant breast lesions, while outlining highly practical issues that are in practice today in breast pathology, such as evaluation of estrogen, progesterone receptors, and HER-2. Written by experts in the field, Precision Molecular Pathology of Breast Cancer is a valuable resource that covers the current practice of breast pathology and looks into the future with an emphasis on the molecular basis of breast cancer.

Cancer and Inflammation

Cancer and Inflammation
Author: Derek J. Chadwick,Jamie A. Goode
Publsiher: John Wiley & Sons
Total Pages: 290
Release: 2004-06-25
ISBN 10: 0470856726
ISBN 13: 9780470856727
Language: EN, FR, DE, ES & NL

Cancer and Inflammation Book Review:

Chronic inflammation predisposes to some forms of cancer and the host response to malignant disease shows several parallels with inflammation and wound healing. The cells involved in inflammation are detected in a range of common cancers, together with the inflammatory cytokines and members of the chemokine ligand/receptor systems. Neutralization or deletion of the gene for some inflammatory cytokines confers resistance to tumour induction and experimental metastasis. Over-expression of such cytokines in tumour cells may enhance malignant potential. Certain chemokines are likely to subvert antitumour immunity by favouring development of ineffective Type 2 responses. Tumour cells may even utilize chemokine receptors in homing to lymph nodes and other organs. Thus, the cells, cytokines and chemokines found in tumours are more likely to contribute to tumour growth, progression and immunosuppression than they are to mount an effective host antitumour response. This book draws together contributions from an international group of scientists and clinicians from diverse disciplines, ranging from epidemiology to immunology, cell biology, molecular oncology, molecular medicine and pharmacology to debate these and related issues. Topics covered include the epidemiological links between cancer and inflammation, the parallels between inflammation and cancer, the role of inflammation in cancer, inflammatory genes as risk factors for cancer initiation and progression, inflammation and cancer angiogenesis, and preventative and therapeutic strategies. Related Novartis Foundation symposia: 252 Generation and Effector Functions of Regulatory Lymphocytes Chair: Jean-François Bach 254 Immunoinformatics: Bioinformatic Strategies for Better Understanding of Immune Function Chair: Hans-Georg Rammensee

Immunology

Immunology
Author: Anil Sharma
Publsiher: Jenny Stanford Publishing
Total Pages: 246
Release: 2019-02-27
ISBN 10: 9789814774512
ISBN 13: 9814774510
Language: EN, FR, DE, ES & NL

Immunology Book Review:

Immunology has emerged as a key component of the curricula of graduate and postgraduate courses in biotechnology, microbiology, biochemistry, bioinformatics, and other interdisciplinary fields of biology, including zoology, veterinary science, and medicine. As a basic introductory textbook on one of the fastest-moving and most challenging areas of immunological science, this book contains the most recent information about immunologic mechanisms and their importance, along with various molecular techniques employed in immunology. The short and concise text helps make the structures, processes, and interactions of the immune system easily comprehensible. The book includes chapters on immunoinformatics as well as the immune system of the brain, rarely found in any of the immunology books published so far. Many diverse and interesting aspects of the advances in immunology have also been covered, including tumor immunology and immunodeficiency disorders. The easy-to-understand concepts presented in the textbook make it an ideal companion for learners preparing for competitive and other examinations. Undergraduate, postgraduate, and PhD students, people from the industry and academia, and research scholars will immensely benefit from it.

Reverse Vaccinology

Reverse Vaccinology
Author: Pedro A Reche,Richard Moxon,Rino Rappuoli
Publsiher: Frontiers Media SA
Total Pages: 329
Release: 2020-01-15
ISBN 10: 2889633853
ISBN 13: 9782889633852
Language: EN, FR, DE, ES & NL

Reverse Vaccinology Book Review:

OMICS

OMICS
Author: Debmalya Barh,Kenneth Blum,Margaret A. Madigan
Publsiher: CRC Press
Total Pages: 622
Release: 2016-04-19
ISBN 10: 1439850097
ISBN 13: 9781439850091
Language: EN, FR, DE, ES & NL

OMICS Book Review:

A reflection of the explosion of research and development in this field, OMICS: Biomedical Perspectives and Applications explores applications of omics in bioinformatics, cancer research and therapy, diabetes research, plant science, molecular biology, and neurosciences. A select editorial panel of experts discusses their cutting edge omics research and novel technologies, supplying a basic platform of methods and applications and a resource for enhanced cross-pollination in a multiomics approach to future endeavors in the fertile fields of omics research. After an introduction on the omics universe, the book presents modern omics and its applications in nanotechnology, genomics, proteomics, metagenomics, toxicogenomics, immunomics, nutrigenomics, diabetes, neurology, cardiology, and cancer to name just a few. The book begins with an overview of omics and omic technologies such as cellomics, glycomics, and lipidomics. It also discusses bioinformatics, demonstrating how it can be a tool in omics, and examines the various approaches of omics technology in toxicology research and applications in biomedical sciences. While there are a long list of omics books available, most focus narrowly on one area. Presenting a wide view of the current status of integrative omics, this resource contains complete coverage of omics in research and therapy, ranging from neuroscience to cardiology. It collates recent developments in the field into a state-of-the-art framework for this discipline.

Molecular Biology of B Cells

Molecular Biology of B Cells
Author: Tasuku Honjo,Michael Reth,Andreas Radbruch,Frederick Alt
Publsiher: Elsevier
Total Pages: 600
Release: 2014-10-09
ISBN 10: 0123984904
ISBN 13: 9780123984906
Language: EN, FR, DE, ES & NL

Molecular Biology of B Cells Book Review:

Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of B Cells, Second Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with updated research on microRNAs in B cell development and immunity, new developments in understanding lymphoma biology, and therapeutic targeting of B cells for clinical application. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, Second Edition is the definitive resource, vital for researchers across molecular biology, immunology and genetics. Covers signaling mechanisms regulating B cell differentiation Provides information on the development of therapeutics using monoclonal antibodies and clinical application of Ab Contains studies on B cell tumors from various stages of B lymphocytes Offers an integrated view of all aspects of B cells to produce a normal immune response

Preclinical Development Handbook

Preclinical Development Handbook
Author: Shayne Cox Gad
Publsiher: John Wiley & Sons
Total Pages: 1352
Release: 2008-03-14
ISBN 10: 0470248475
ISBN 13: 9780470248478
Language: EN, FR, DE, ES & NL

Preclinical Development Handbook Book Review:

A clear, straightforward resource to guide you through preclinical drug development Following this book's step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic, comprehensive reference to prioritizing and optimizing leads, dose formulation, ADME, pharmacokinetics, modeling, and regulations. This authoritative, easy-to-use resource covers all the issues that need to be considered and provides detailed instructions for current methods and techniques. Each chapter is written by one or more leading experts in the field. These authors, representing the many disciplines involved in preclinical toxicology screening and testing, give you the tools needed to apply an effective multidisciplinary approach. The editor has carefully reviewed all the chapters to ensure that each one is thorough, accurate, and clear. Among the key topics covered are: * Modeling and informatics in drug design * Bioanalytical chemistry * Absorption of drugs after oral administration * Transporter interactions in the ADME pathway of drugs * Metabolism kinetics * Mechanisms and consequences of drug-drug interactions Each chapter offers a full exploration of problems that may be encountered and their solutions. The authors also set forth the limitations of various methods and techniques used in determining the safety and efficacy of a drug during the preclinical stage. This publication should be readily accessible to all pharmaceutical scientists involved in preclinical testing, enabling them to perform and document preclinical safety tests to meet all FDA requirements before clinical trials may begin.

Translational Bioinformatics and Systems Biology Methods for Personalized Medicine

Translational Bioinformatics and Systems Biology Methods for Personalized Medicine
Author: Qing Yan
Publsiher: Academic Press
Total Pages: 182
Release: 2017-04-18
ISBN 10: 0128043881
ISBN 13: 9780128043882
Language: EN, FR, DE, ES & NL

Translational Bioinformatics and Systems Biology Methods for Personalized Medicine Book Review:

Translational Bioinformatics and Systems Biology Methods for Personalized Medicine introduces integrative approaches in translational bioinformatics and systems biology to support the practice of personalized, precision, predictive, preventive, and participatory medicine. Through the description of important cutting-edge technologies in bioinformatics and systems biology, readers may gain an essential understanding of state-of-the-art methodologies. The book discusses topics such as the challenges and tasks in translational bioinformatics; pharmacogenomics, systems biology, and personalized medicine; and the applicability of translational bioinformatics for biomarker discovery, epigenomics, and molecular dynamics. It also discusses data integration and mining, immunoinformatics, and neuroinformatics. With broad coverage of both basic scientific and clinical applications, this book is suitable for a wide range of readers who may not be scientists but who are also interested in the practice of personalized medicine. Introduces integrative approaches in translational bioinformatics and systems biology to support the practice of personalized, precision, predictive, preventive, and participatory medicine Presents a problem-solving oriented methodology to deal with practical problems in various applications Covers both basic scientific and clinical applications in order to enhance the collaboration between researchers and clinicians Brings integrative and multidisciplinary approaches to bridge the gaps among various knowledge domains in the field

Immune System Modelling and Simulation

Immune System Modelling and Simulation
Author: Filippo Castiglione,Franco Celada
Publsiher: CRC Press
Total Pages: 286
Release: 2015-04-07
ISBN 10: 1466597496
ISBN 13: 9781466597495
Language: EN, FR, DE, ES & NL

Immune System Modelling and Simulation Book Review:

The book describes a computational model of the immune system reaction, C-ImmSim, built along the lines of the computer model known as the Celada-Seiden model (CS-model). The computational counterpart of the CS-model is called IMMSIM which stands for IMMune system SIMulator. IMMSIM was written in 1992 by the physicist Phil E. Seiden and the immunologist Franco Celada. This model was built around the idea of developing a computerized system to perform experiments similar in vivo experiments; a tool developed to help biologists testing theories and hypothesis about how the immune system works. C-ImmSim is best viewed as a collection of models in a single program. It incorporates the principal core facts of today’s immunological knowledge, such as the diversity of specific elements, MHC restriction, clonal selection, thymic education of T cells, antigen processing and presentation (both the cytosolic and endocytic pathways are implemented), cell-cell cooperation, homeostasis of cells created by the bone marrow, hyper mutation of antibodies, maturation of the cellular and humoral response, and memory. Besides, an antigen can represent a bacterium, a virus, or an allergen or a tumor cell. C-ImmSim has been recently customized to simulate the HIV-1 infection. Moreover, it can simulate the immunotherapy for cancer. These features are all present in the code and people can choose to turn them on and off at compiling time. The book presents the basic model as well as the various customizations to implement the description of different diseases and the way they have been used in practice to produce new knowledge either from hypothesis or from lab-experiment data. In this respect, the book can be used as a practical guide to implement a computational model with which to study a specific disease and to try to address realistic clinical questions.

Vaccines

Vaccines
Author: Farhat Afrin,Hassan Hemeg,Hani Ozbak
Publsiher: BoD – Books on Demand
Total Pages: 192
Release: 2017-09-06
ISBN 10: 9535134752
ISBN 13: 9789535134756
Language: EN, FR, DE, ES & NL

Vaccines Book Review:

Microbes that elude host's defenses and have developed resistance to the existing antibiotic arsenal continuously invade the human body. Cure for such diseases is inevitable as it may result in high morbidity and mortality, if not properly treated. Vaccination represents the most cost-effective way for disease prevention. Vaccines activate sentinels of the immune system including macrophages and T, B, and dendritic cells to release a battery of effector molecules and cytokines and ward off infection. For long-lasting protection, the memory cells also need to be evoked. This book encompasses biotechnological vaccines in clinical use, cocooning, disease resurgence postvaccination and other vaccine adverse effects, prospects of therapeutic versus prophylactic vaccines, and design of effective vaccines using bioinformatic tools and engineering molecular pattern interactions.

Clinical Applications of Immunomics

Clinical Applications of Immunomics
Author: Andras Falus
Publsiher: Springer Science & Business Media
Total Pages: 275
Release: 2008-12-23
ISBN 10: 9780387792088
ISBN 13: 0387792082
Language: EN, FR, DE, ES & NL

Clinical Applications of Immunomics Book Review:

Innate immunity is one the most evolutionally conserved systems, designed to protect the organism from viruses and bacterial infections, stress and many other types of attacks from the outside world. During the past decade, the capacity of molecular biology and information technology to produce and analyse data have grown exponentially, rapidly reforming many aspects of immunology research in the post-genomics era. As a result, scientific understanding of signalling networks governing the innate immunity response in human tissues and other organisms has evolved beyond recognition, compared to even just a decade ago. Many strategies have been designed over the years to identify novel proteins, which have a crucial role in innate immunity responses by regulating particular signalling pathways. These projects had many advantages, including the definition of novel drug targets, as exemplified by the recent success of anti-TNF therapy, as well as leading to a better, system-wide understanding of the molecular control of innate immunity. In the past few years, a new concept, Immunomics, has been adopted to define an emerging, multidisciplinary field of research (Schonbach, 2003). Although rapid progress has been made to identify the proteins playing pivotal roles in the innate immunity–related signalling pathways (for example, TIR signalling pathways), the catalogue of proteins with a key regulatory function identified and studied is far from completed. Novel proteins need to be char- terised to gain a more comprehensive picture of how signalling networks are regulated.

Immunological Bioinformatics

Immunological Bioinformatics
Author: Ole Lund,Morten Nielsen,Søren Brunak,Claus Lundegaard,Can Kesmir
Publsiher: MIT Press
Total Pages: 296
Release: 2005
ISBN 10: 9780262122801
ISBN 13: 0262122804
Language: EN, FR, DE, ES & NL

Immunological Bioinformatics Book Review:

Using bioinformatics methods to generate a systems-level view of the immune system; description of the main biological concepts and the new data-driven algorithms. Despite the fact that advanced bioinformatics methodologies have not been used as extensively in immunology as in other subdisciplines within biology, research in immunological bioinformatics has already developed models of components of the immune system that can be combined and that may help develop therapies, vaccines, and diagnostic tools for such diseases as AIDS, malaria, and cancer. In a broader perspective, specialized bioinformatics methods in immunology make possible for the first time a systems-level understanding of the immune system. The traditional approaches to immunology are reductionist, avoiding complexity but providing detailed knowledge of a single event, cell, or molecular entity. Today, a variety of experimental bioinformatics techniques connected to the sequencing of the human genome provides a sound scientific basis for a comprehensive description of the complex immunological processes. This book offers a description of bioinformatics techniques as they are applied to immunology, including a succinct account of the main biological concepts for students and researchers with backgrounds in mathematics, statistics, and computer science as well as explanations of the new data-driven algorithms in the context of biological data that will be useful for immunologists, biologists, and biochemists working on vaccine design. In each chapter the authors show interesting biological insights gained from the bioinformatics approach. The book concludes by explaining how all the methods presented in the book can be integrated to identify immunogenic regions in microorganisms and host genomes.