Identification and Quantification of Drugs Metabolites Drug Metabolizing Enzymes and Transporters

Identification and Quantification of Drugs  Metabolites  Drug Metabolizing Enzymes  and Transporters
Author: Shuguang Ma,Swapan Chowdhury
Publsiher: Elsevier
Total Pages: 708
Release: 2020-07-09
ISBN 10: 0128200197
ISBN 13: 9780128200193
Language: EN, FR, DE, ES & NL

Identification and Quantification of Drugs Metabolites Drug Metabolizing Enzymes and Transporters Book Review:

Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters, Second Edition, is completely updated to provide an overview of the last decade’s numerous advances in analytical technologies for detection and quantification of drugs, metabolites, and biomarkers. This new edition goes beyond LC-MS and features all-new chapters on how to evaluate drug absorption, distribution, metabolism, and excretion, potential for hepatic and renal toxicity, immunogenicity of biotherapeutics and translational tools for predicting human dosage, safety and efficacy of small molecules and biologics. This book will be an important handbook and desk reference for pharmacologists, toxicologists, clinical scientists, and students interested in the fields of pharmacology, biochemistry, and drug metabolism. Four sections in the book with 24 chapters give readers an overview of state-of-the-art techniques for identifying and quantifying drugs, metabolites and biomarkers, including a chapter on new approaches for quantification of enzymes and transporters in different tissues Focuses on the role of drug metabolism enzymes, transporters in disposition and drug-drug interactions, as well as strategies for evaluating drug metabolism and safety using advanced liver and kidney models. Discussions on immunogenicity risks of biologics and their evaluation methods have been included Includes several chapters on advanced translational sciences to predict human dosage, pharmacokinetics and efficacy for small molecules and biotherapeutics All chapters are written by experts with a wide range of practical experience from the industry and academia

Identification and Quantification of Drugs Metabolites and Metabolizing Enzymes by LC MS

Identification and Quantification of Drugs  Metabolites and Metabolizing Enzymes by LC MS
Author: Swapan Chowdhury
Publsiher: Elsevier
Total Pages: 354
Release: 2005-11-04
ISBN 10: 9780080456065
ISBN 13: 0080456065
Language: EN, FR, DE, ES & NL

Identification and Quantification of Drugs Metabolites and Metabolizing Enzymes by LC MS Book Review:

As new techniques of transferring from liquid to gas phase and measuring masses of drug molecules and metabolites become more prevalent, so do the technical challenges of putting these techniques into proper use, as well as the task of consolidating emerging applications. Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS, Volume 6 fills the gap in the lack of presently available literature by providing a critical review in the current use of liquid chromatography-mass spectrometry (LC-MS) in drug discovery and development. With chapters written by experts with a wide range of practical experience from the pharmaceutical industry, emphasis is placed on techniques and applications. The book also includes chapters on how to utilize LC-MS instrumentation for current drug metabolism problems. This book is intended for those beginning to use LC-MS for drug metabolism studies as well as for those considered advanced practitioners. * Introduces readers to the practical applications of modern liquid chromatography-mass spectrometry (LC-MS) in a wide range of drug metabolism studies· * Provides a comprehensive description of different forms of metabolites, with detailed discussion on the wide range of methodologies used to identify them * Highlights problems associated with drug quantification and offers practical solutions

Drug Transporters

Drug Transporters
Author: Martin F. Fromm,Richard B. Kim
Publsiher: Springer Science & Business Media
Total Pages: 454
Release: 2010-11-19
ISBN 10: 3642145418
ISBN 13: 9783642145414
Language: EN, FR, DE, ES & NL

Drug Transporters Book Review:

It is increasingly recognized that various transporter proteins are expressed throughout the body and determine absorption, tissue distribution, biliary and renal elimination of endogenous compounds and drugs and drug effects. This book will give an overview on the transporter families which are most important for drug therapy. Most chapters will focus on one transporter family highlighting tissue expression, substrates, inhibitors, knock-out mouse models and clinical studies.

Biodegradation and Biodeterioration at the Nanoscale

Biodegradation and Biodeterioration at the Nanoscale
Author: Hafiz M.N. Iqbal,Muhammad Bilal,Tuan Anh Nguyen,Ghulam Yasin
Publsiher: Elsevier
Total Pages: 750
Release: 2021-10-08
ISBN 10: 0128241799
ISBN 13: 9780128241790
Language: EN, FR, DE, ES & NL

Biodegradation and Biodeterioration at the Nanoscale Book Review:

Biodegradation and Biodeterioration at the Nanoscale describes the biodegradation and biodeterioration of materials in the presence of nanomaterials. The book's chapters focus on the basic principles, action mechanisms and promising applications of advanced nanomaterials, along with their integration with biotechnological processes for controlled degradation and deterioration of materials. In addition, the current research indications, positive or negative environmental impacts, legislation and future directions are also discussed. This book is an important reference source for researchers, engineers and scientists working in environmental remediation, biotechnology, materials science, corrosion and nanotechnology. Provides detailed coverage on how nano-biomaterials degrade and deteriorate Compares how different types of bionanomaterials decompose Explains how the priorities of bionanomaterials affect their deterioration rate

Drug Metabolism in Drug Design and Development

Drug Metabolism in Drug Design and Development
Author: Donglu Zhang,Mingshe Zhu,William G. Humphreys
Publsiher: John Wiley & Sons
Total Pages: 448
Release: 2007-11-16
ISBN 10: 9780470191682
ISBN 13: 0470191686
Language: EN, FR, DE, ES & NL

Drug Metabolism in Drug Design and Development Book Review:

The essentials of drug metabolism vital to developing new therapeutic entities Information on the metabolism and disposition of candidate drugs is a critical part of all aspects of the drug discovery and development process. Drug metabolism, as practiced in the pharmaceutical industry today, is a complex, multidisciplinary field that requires knowledge of sophisticated analytical technologies and expertise in mechanistic and kinetic enzymology, organic reaction mechanism, pharmacokinetic analysis, animal physiology, basic chemical toxicology, preclinical pharmacology, and molecular biology. With chapters contributed by experts in their specific areas, this reference covers: * Basic concepts of drug metabolism * The role of drug metabolism in the pharmaceutical industry * Analytical techniques in drug metabolism * Common experimental approaches and protocols Drug Metabolism in Drug Design and Development emphasizes practical considerations such as the data needed, the experiments and analytical methods typically employed, and the interpretation and application of data. Chapters highlight facts, common protocols, detailed experimental designs, applications, and limitations of techniques. This is a comprehensive, hands-on reference for drug metabolism researchers as well as other professionals involved in pre-clinical drug discovery and development.

Drug Metabolism Pharmacokinetics and Bioanalysis

Drug Metabolism  Pharmacokinetics and Bioanalysis
Author: Hye Suk Lee,Kwang-Hyeon Liu
Publsiher: MDPI
Total Pages: 230
Release: 2019-06-12
ISBN 10: 3038979163
ISBN 13: 9783038979166
Language: EN, FR, DE, ES & NL

Drug Metabolism Pharmacokinetics and Bioanalysis Book Review:

Drug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. Recently, drug metabolism and transport by phase II drug metabolizing enzymes and drug transporters, respectively, as well as phase I drug metabolizing enzymes, have been studied. A combination of biochemical advances in the function and regulation of drug metabolizing enzymes and automated analytical technologies are revolutionizing drug metabolism research. There are also potential drug–drug interactions with co-administered drugs due to inhibition and/or induction of drug metabolic enzymes and drug transporters. In addition, drug interaction studies have been actively performed to develop substrate cocktails that do not interfere with each other and a simultaneous analytical method of substrate drugs and their metabolites using a tandem mass spectrometer. This Special Issue has the aim of highlighting current progress in drug metabolism/pharmacokinetics, drug interactions, and bioanalysis.

Topics on Drug Metabolism

Topics on Drug Metabolism
Author: James Paxton
Publsiher: BoD – Books on Demand
Total Pages: 308
Release: 2012-02-22
ISBN 10: 9535100998
ISBN 13: 9789535100997
Language: EN, FR, DE, ES & NL

Topics on Drug Metabolism Book Review:

In order to avoid late-stage drug failure due to factors such as undesirable metabolic instability, toxic metabolites, drug-drug interactions, and polymorphic metabolism, an enormous amount of effort has been expended by both the pharmaceutical industry and academia towards developing more powerful techniques and screening assays to identify the metabolic profiles and enzymes involved in drug metabolism. This book presents some in-depth reviews of selected topics in drug metabolism. Among the key topics covered are: the interplay between drug transport and metabolism in oral bioavailability; the influence of genetic and epigenetic factors on drug metabolism; impact of disease on transport and metabolism; and the use of novel microdosing techniques and novel LC/MS and genomic technologies to predict the metabolic parameters and profiles of potential new drug candidates.

Drug Transporters

Drug Transporters
Author: Glynis Nicholls,Kuresh Youdim
Publsiher: Royal Society of Chemistry
Total Pages: 463
Release: 2016-08-16
ISBN 10: 1782623795
ISBN 13: 9781782623793
Language: EN, FR, DE, ES & NL

Drug Transporters Book Review:

Understanding and quantifying the effects of membrane transporters within the human body is essential for modulating drug safety and drug efficacy. In this first volume on Drug Transporters, the current knowledge and techniques in the transporter sciences and their relations to drug metabolism and pharmacokinetics are comprehensively reviewed. The second volume of the book is specifically dedicated to emerging science and technologies, highlighting potential areas for future advances within the drug transporter field. The topics covered in both volumes ensure that all relevant aspects of transporters are described across the drug development process, from in silico models and preclinical tools through to the potential impact of transporters in the clinic. Contributions are included from expert leaders in the field, at-the-bench industrial scientists, renowned academics and international regulators. Case studies and emerging developments are highlighted, together with the merits and limitations of the available methods and tools, and extensive references to reviews on specific in-depth topics are also included for those wishing to pursue their knowledge further. As such, this text serves as an essential handbook of information for postgraduate students, academics, industrial scientists and regulators who wish to understand the role of transporters in absorption, distribution, metabolism, and excretion processes. In addition, it is also a useful reference tool on the models and calculations necessary to predict their effect on human pharmacokinetics and pharmacodynamics.

Early Drug Development

Early Drug Development
Author: Mitchell N. Cayen
Publsiher: John Wiley & Sons
Total Pages: 654
Release: 2011-02-25
ISBN 10: 9781118035207
ISBN 13: 1118035208
Language: EN, FR, DE, ES & NL

Early Drug Development Book Review:

The focus of early drug development has been the submission of an Investigational New Drug application to regulatory agencies. Early Drug Development: Strategies and Routes to First-in-Human Trials guides drug development organizations in preparing and submitting an Investigational New Drug (IND) application. By explaining the nuts and bolts of preclinical development activities and their interplay in effectively identifying successful clinical candidates, the book helps pharmaceutical scientists determine what types of discovery and preclinical research studies are needed in order to support a submission to regulatory agencies.

Handbook of Radioactivity Analysis

Handbook of Radioactivity Analysis
Author: Michael F. L'Annunziata
Publsiher: Academic Press
Total Pages: 1074
Release: 2020-03-07
ISBN 10: 0128143967
ISBN 13: 9780128143964
Language: EN, FR, DE, ES & NL

Handbook of Radioactivity Analysis Book Review:

Handbook of Radioactivity Analysis: Radiation Physics and Detectors, Volume One, and Radioanalytical Applications, Volume Two, Fourth Edition, constitute an authoritative reference on the principles, practical techniques and procedures for the accurate measurement of radioactivity - everything from the very low levels encountered in the environment, to higher levels measured in radioisotope research, clinical laboratories, biological sciences, radionuclide standardization, nuclear medicine, nuclear power, and fuel cycle facilities, and in the implementation of nuclear forensic analysis and nuclear safeguards. It includes sample preparation techniques for all types of matrices found in the environment, including soil, water, air, plant matter and animal tissue, and surface swipes. Users will find the latest advances in the applications of radioactivity analysis across various fields, including environmental monitoring, radiochemical standardization, high-resolution beta imaging, automated radiochemical separation, nuclear forensics, and more. Spans two volumes, Radiation Physics and Detectors and Radioanalytical Applications Includes a new chapter on the analysis of environmental radionuclides Provides the latest advances in the applications of liquid and solid scintillation analysis, alpha- and gamma spectrometry, mass spectrometric analysis, Cherenkov counting, flow-cell radionuclide analysis, radionuclide standardization, aerosol analysis, high-resolution beta imaging techniques, analytical techniques in nuclear forensics, and nuclear safeguards Describes the timesaving techniques of computer-controlled automatic separation and activity analysis of radionuclides Provides an extensive table of the radiation characteristics of most radionuclides of interest for the radioanalytical chemist

Drug Discovery

Drug Discovery
Author: Varaprasad Bobbarala PhD
Publsiher: BoD – Books on Demand
Total Pages: 192
Release: 2018-09-19
ISBN 10: 1789236967
ISBN 13: 9781789236965
Language: EN, FR, DE, ES & NL

Drug Discovery Book Review:

The book "Drug Discovery - Concepts to Market" is a collection of reviewed and relevant research chapters, offering a comprehensive overview of recent developments in the latest drug discovery trends that have been revolutionized with up-to-date technological developments. This book comprises single chapters authored by various researchers and edited by an expert active in the drug development research area. All chapters are independently complete but united under a common research study topic. This publication aims to provide a thorough overview of the latest research efforts in this field from international authors and open new possible research paths for further novel developments.

Biological Potential and Medical Use of Secondary Metabolites

Biological Potential and Medical Use of Secondary Metabolites
Author: Ana M. L Seca,Diana Cláudia Pinto
Publsiher: MDPI
Total Pages: 284
Release: 2019-07-26
ISBN 10: 3039211870
ISBN 13: 9783039211876
Language: EN, FR, DE, ES & NL

Biological Potential and Medical Use of Secondary Metabolites Book Review:

Many macro and micro species, from terrestrial and aquatic environments, produce structurally unique compounds and, in many countries, still are the primary sources of medicines. In fact, secondary metabolites are an important source of chemotherapeutic agents but are also lead compounds for synthetic modification and the optimization of biological activity. Therefore, the exploitation of secondary metabolites, or their inspired synthetic compounds, offers excellent opportunities for the pharmaceutical industry. This Medicines Special Issue focuses on the great potential of secondary metabolites for therapeutic application. The Special Issue contains 16 articles reporting relevant experimental results, and an overview of bioactive secondary metabolites, their biological effects, and new methodologies that improve and accelerate the process of obtained lead compounds with regard to new drug development. We would like to thank all 83 authors, from all over the world, for their valuable contributions to this Special Issue.

Reactive Drug Metabolites

Reactive Drug Metabolites
Author: Amit S. Kalgutkar,Deepak Dalvie,R. Scott Obach,Dennis A. Smith
Publsiher: John Wiley & Sons
Total Pages: 402
Release: 2012-09-06
ISBN 10: 352765576X
ISBN 13: 9783527655762
Language: EN, FR, DE, ES & NL

Reactive Drug Metabolites Book Review:

Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation, including a discussion of the structure-toxicity relationships for drugs. Two chapters are dedicated to the currently hot topics of herbal constituents and IADRs. The next part covers current strategies and approaches to evaluate the reactive metabolite potential of new drug candidates, both by predictive and by bioanalytical methods. There then follows an in-depth analysis of the toxicological potential of the top 200 prescription drugs, illustrating the power and the limits of the toxicophore concept, backed by numerous case studies. Finally, a risk-benefi t approach to managing the toxicity risk of reactive metabolite-prone drugs is presented. Since the authors carefully develop the knowledge needed, from fundamental considerations to current industry standards, no degree in pharmacology is required to read this book, making it perfect for medicinal chemists without in-depth pharmacology training.

Vitamin D

Vitamin D
Author: H.F. DeLuca
Publsiher: Springer Science & Business Media
Total Pages: 80
Release: 2012-12-06
ISBN 10: 3642813062
ISBN 13: 9783642813061
Language: EN, FR, DE, ES & NL

Vitamin D Book Review:

Because diseases of the bone are often less acute and less lifethreatening than dis eases of the circulatory system, gastrointestinal tract, kidney, liver, and the nervous system, they have received a disproportionately smaller amount of attention in the medical world. With the average increasing life span of man as a result of improve ments in modern medicine, espe~ially in the pediatric field, the seriousness of many metabolic bone diseases has indeed become more obvious. In addition, other improvements in medicine, such as hemodialysis for the preservation of renal failure patients, have permitted the development of other consequences of diseased kidneys, one of which is the appearance of renal osteodystrophy. Finally, the appearance of several genetic disorders in the area of metabolic bone disease has been underscored by the solution of other pediatric diseas~s of much more serious consequences. These emerging problems all suggest that much remains to be learned concerning the sys temic control of bone, both as a structural organ and as a reservoir for the important elements of calcium and phosphorus so essential for the support of life in complex multicellular organisms of which man is the most important. As will be demonstrated in the historical portion of this manuscript, the existence of the three most important humoral factors regulating bone metabolism and func tion are now known.

Handbook of Drug Nutrient Interactions

Handbook of Drug Nutrient Interactions
Author: Joseph I. Boullata,Vincent T. Armenti
Publsiher: Springer Science & Business Media
Total Pages: 824
Release: 2010-03-17
ISBN 10: 160327362X
ISBN 13: 9781603273626
Language: EN, FR, DE, ES & NL

Handbook of Drug Nutrient Interactions Book Review:

Handbook of Drug-Nutrient Interactions, Second Edition is an essential new work that provides a scientific look behind many drug-nutrient interactions, examines their relevance, offers recommendations, and suggests research questions to be explored. In the five years since publication of the first edition of the Handbook of Drug-Nutrient Interactions new perspectives have emerged and new data have been generated on the subject matter. Providing both the scientific basis and clinical relevance with appropriate recommendations for many interactions, the topic of drug-nutrient interactions is significant for clinicians and researchers alike. For clinicians in particular, the book offers a guide for understanding, identifying or predicting, and ultimately preventing or managing drug-nutrient interactions to optimize patient care. Divided into six sections all chapters have been revised or are new to this edition. Chapters balance the most technical information with practical discussions and include outlines that reflect the content; discussion questions that can guide the reader to the critical areas covered in each chapter, complete definitions of terms with the abbreviation fully defined and consistent use of terms between chapters. The editors have performed an outstanding service to clinical pharmacology and pharmaco-nutrition by bringing together a multi-disciplinary group of authors. Handbook of Drug-Nutrient Interactions, Second Edition is a comprehensive up-to-date text for the total management of patients on drug and/or nutrition therapy but also an insight into the recent developments in drug-nutrition interactions which will act as a reliable reference for clinicians and students for many years to come.

The Organic Chemistry of Drug Design and Drug Action

The Organic Chemistry of Drug Design and Drug Action
Author: Richard B. Silverman
Publsiher: Elsevier
Total Pages: 617
Release: 2012-12-02
ISBN 10: 0080513379
ISBN 13: 9780080513379
Language: EN, FR, DE, ES & NL

The Organic Chemistry of Drug Design and Drug Action Book Review:

Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and includes chapter problems and other elements that make the book more useful for course instruction. New edition includes new chapter problems and exercises to help students learn, plus extensive references and illustrations Clearly presents an organic chemist's perspective of how drugs are designed and function, incorporating the extensive changes in the drug industry over the past ten years Well-respected author has published over 200 articles, earned 21 patents, and invented a drug that is under consideration for commercialization

Handbook of Radioactivity Analysis

Handbook of Radioactivity Analysis
Author: Michael F. L'Annunziata
Publsiher: Academic Press
Total Pages: 1108
Release: 2020-03-03
ISBN 10: 0128143983
ISBN 13: 9780128143988
Language: EN, FR, DE, ES & NL

Handbook of Radioactivity Analysis Book Review:

Handbook of Radioactivity Analysis: Radiation Physics and Detectors, Volume One, and Radioanalytical Applications, Volume Two, Fourth Edition, is an authoritative reference on the principles, practical techniques and procedures for the accurate measurement of radioactivity - everything from the very low levels encountered in the environment, to higher levels measured in radioisotope research, clinical laboratories, biological sciences, radionuclide standardization, nuclear medicine, nuclear power, and fuel cycle facilities, and in the implementation of nuclear forensic analysis and nuclear safeguards. It includes sample preparation techniques for all types of matrices found in the environment, including soil, water, air, plant matter and animal tissue, and surface swipes. Users will find a detailed discussion of our current understanding of the atomic nucleus, nuclear stability and decay, nuclear radiation, and the interaction of radiation with matter relating to the best methods for radionuclide detection and measurement. Spans two volumes, Radiation Physics and Detectors and Radioanalytical Applications Includes a much-expanded treatment of calculations required in the measurement of radionuclide decay, energy of decay, nuclear reactions, radiation attenuation, nuclear recoil, cosmic radiation, and synchrotron radiation Includes the latest advances in liquid and solid scintillation analysis, alpha- and gamma spectrometry, mass spectrometric analysis, gas ionization and nuclear track analysis, and neutron detection and measurement Covers high-sample-throughput microplate techniques and multi-detector assay methods

Controlled Pulmonary Drug Delivery

Controlled Pulmonary Drug Delivery
Author: Hugh D.C. Smyth,Anthony J. Hickey
Publsiher: Springer Science & Business Media
Total Pages: 558
Release: 2011-06-24
ISBN 10: 1441997458
ISBN 13: 9781441997456
Language: EN, FR, DE, ES & NL

Controlled Pulmonary Drug Delivery Book Review:

The pace of new research and level of innovation repeatedly introduced into the field of drug delivery to the lung is surprising given its state of maturity since the introduction of the pressurized metered dose inhaler over a half a century ago. It is clear that our understanding of pulmonary drug delivery has now evolved to the point that inhalation aerosols can be controlled both spatially and temporally to optimize their biological effects. These abilities include controlling lung deposition, by adopting formulation strategies or device technologies, and controlling drug uptake and release through sophisticated particle technologies. The large number of contributions to the scientific literature and variety of excellent texts published in recent years is evidence for the continued interest in pulmonary drug delivery research. This reference text endeavors to bring together the fundamental theory and practice of controlled drug delivery to the airways that is unavailable elsewhere. Collating and synthesizing the material in this rapidly evolving field presented a challenge and ultimately a sense of achievement that is hopefully reflected in the content of the volume.

Human Drug Metabolism

Human Drug Metabolism
Author: Michael D. Coleman
Publsiher: John Wiley & Sons
Total Pages: 360
Release: 2010-03-30
ISBN 10: 9780470689349
ISBN 13: 047068934X
Language: EN, FR, DE, ES & NL

Human Drug Metabolism Book Review:

Human Drug Metabolism, An Introduction, Second Edition provides an accessible introduction to the subject and will be particularly invaluable to those who already have some understanding of the life sciences. Completely revised and updated throughout, the new edition focuses only on essential chemical detail and includes patient case histories to illustrate the clinical consequences of changes in drug metabolism and its impact on patient welfare. After underlining the relationship between efficacy, toxicity and drug concentration, the book then considers how metabolizing systems operate and how they impact upon drug concentration, both under drug pressure and during inhibition. Factors affecting drug metabolism, such as genetic polymorphisms, age and diet are discussed and how metabolism can lead to toxicity is explained. The book concludes with the role of drug metabolism in the commercial development of therapeutic agents as well as the pharmacology of some illicit drugs.

Advanced Gas Chromatography

Advanced Gas Chromatography
Author: Mustafa Ali Mohd
Publsiher: BoD – Books on Demand
Total Pages: 472
Release: 2012-03-21
ISBN 10: 9535102982
ISBN 13: 9789535102984
Language: EN, FR, DE, ES & NL

Advanced Gas Chromatography Book Review:

Progress in agricultural, biomedical and industrial applications' is a compilation of recent advances and developments in gas chromatography and its applications. The chapters cover various aspects of applications ranging from basic biological, biomedical applications to industrial applications. Book chapters analyze new developments in chromatographic columns, microextraction techniques, derivatisation techniques and pyrolysis techniques. The book also includes several aspects of basic chromatography techniques and is suitable for both young and advanced chromatographers. It includes some new developments in chromatography such as multidimensional chromatography, inverse chromatography and some discussions on two-dimensional chromatography. The topics covered include analysis of volatiles, toxicants, indoor air, petroleum hydrocarbons, organometallic compounds and natural products. The chapters were written by experts from various fields and clearly assisted by simple diagrams and tables. This book is highly recommended for chemists as well as non-chemists working in gas chromatography.