Human Embryos and Preimplantation Genetic Technologies

Human Embryos and Preimplantation Genetic Technologies
Author: E. Scott Sills,Gianpiero D. Palermo
Publsiher: Academic Press
Total Pages: 222
Release: 2019-05-01
ISBN 10: 0128167440
ISBN 13: 9780128167441
Language: EN, FR, DE, ES & NL

Human Embryos and Preimplantation Genetic Technologies Book Review:

Human Embryos and Preimplantation Genetic Technologies: Ethical, Social, and Public Policy Aspects presents the first holistic analysis of PGD and PGS as it is practiced and regulated worldwide. In addition to scientific and technical aspects, the book provides perspectives on the ethical, legal, religious, policy and social implications of global assisted reproduction technologies, including in Africa, Asia, Europe, North and South America, and Australia. Chapters cover history, ethics, feminism, family dynamics, psychological and interpersonal factors, the current state of PGD and PGS in 20 different sovereign nations and religious communities, and provide an analysis of public policy concerns and future directions. Provides an in-depth discussion of PGD and PGS as practiced and regulated worldwide Offers an accessible resource for researchers, medical professionals, patients, regulators and policymakers seeking expert opinions on PGS and PGD Contains chapters contributed by international clinicians, researchers and thought leaders in the field of assisted reproductive technology

The Gene Machine

The Gene Machine
Author: Bonnie Rochman
Publsiher: Scientific American / Farrar, Straus and Giroux
Total Pages: 288
Release: 2017-02-28
ISBN 10: 0374713960
ISBN 13: 9780374713966
Language: EN, FR, DE, ES & NL

The Gene Machine Book Review:

A sharp-eyed exploration of the promise and peril of having children in an age of genetic tests and interventions Is screening for disease in an embryo a humane form of family planning or a slippery slope toward eugenics? Should doctors tell you that your infant daughter is genetically predisposed to breast cancer? If tests revealed that your toddler has a genetic mutation whose significance isn’t clear, would you want to know? In The Gene Machine, the award-winning journalist Bonnie Rochman deftly explores these hot-button questions, guiding us through the new frontier of gene technology and how it is transforming medicine, bioethics, health care, and the factors that shape a family. Rochman tells the stories of scientists working to unlock the secrets of the human genome; genetic counselors and spiritual advisers guiding mothers and fathers through life-changing choices; and, of course, parents (including Rochman herself) grappling with revelations that are sometimes joyous, sometimes heartbreaking, but always profound. She navigates the dizzying and constantly expanding array of prenatal and postnatal tests, from carrier screening to genome sequencing, while considering how access to more tests is altering perceptions of disability and changing the conversation about what sort of life is worth living and who draws the line. Along the way, she highlights the most urgent ethical quandary: Is this technology a triumph of modern medicine or a Pandora’s box of possibilities? Propelled by human narratives and meticulously reported, The Gene Machine is both a scientific road map and a meditation on our power to shape the future. It is a book that gets to the very core of what it means to be human.

Comparative Legal Frameworks for Pre Implantation Embryonic Genetic Interventions

Comparative Legal Frameworks for Pre Implantation Embryonic Genetic Interventions
Author: Pin Lean Lau
Publsiher: Springer
Total Pages: 326
Release: 2019-08-01
ISBN 10: 3030223086
ISBN 13: 9783030223083
Language: EN, FR, DE, ES & NL

Comparative Legal Frameworks for Pre Implantation Embryonic Genetic Interventions Book Review:

This book discusses the possibilities for the use of ​international human rights law ​(and specifically, international biomedical laws related to the protection of human rights and the human genome) to provide a guiding framework for the future regulation of genetic modifications applied to human embryos and other precursor materials, when these are made with the aim of implanting a genetically altered embryo in a woman. The significance and timeliness of the work derives from the recent availability of CRISPR/​Cas9 and other gene editing tools, and from lacunae in international law regarding the legality of embryo modification with these tools and appropriate governance structures for the oversight of resulting practices. The emergence of ​improved genome editing tools like CRISPR/Cas9, holds the promise of eradicating genetic diseases in the near future. But its possible future applications with Pre-Implantation Genetic Diagnosis (PGD) raises a plethora of legal and ethical concerns about "remaking" future human beings. The work aims to address an urgent call, to embed these rising concerns about biomedical advancements into the fundamental tailoring of legal systems. Suitable regulatory approaches, coupled with careful reflection of global biomedical laws and individual constitutional systems must be explored. The Book analyzes the impact of reproductive biomedical technologies on the legal and ethical dimensions of regulatory frameworks in selected constitutional systems like the US, the UK, Australia, Malaysia and Thailand. Employing a comparative law methodology, the work reveals a dynamic intersection between legal cultures, socio-philosophical reasoning and the development of a human rights-based framework in bio-political studies. Navigating towards a truly internationalized biomedical approach to emerging technologies, it presents an understanding why a renegotiation and reinvigoration of a contemporary and "new" universal shared values system in the ​international human rights discourse is now necessary.

Textbook of Human Reproductive Genetics

Textbook of Human Reproductive Genetics
Author: Karen Sermon,Stéphane Viville
Publsiher: Cambridge University Press
Total Pages: 200
Release: 2014-04-10
ISBN 10: 1107683580
ISBN 13: 9781107683587
Language: EN, FR, DE, ES & NL

Textbook of Human Reproductive Genetics Book Review:

This book brings together genetics, reproductive biology and medicine for an integrative view of the emerging specialism of reproductive genetics.

Human Preimplantation Embryo Selection

Human Preimplantation Embryo Selection
Author: Jacques Cohen,Kay Elder
Publsiher: CRC Press
Total Pages: 384
Release: 2007-09-26
ISBN 10: 9780203089712
ISBN 13: 0203089715
Language: EN, FR, DE, ES & NL

Human Preimplantation Embryo Selection Book Review:

The most profound dilemma in assisted reproduction to date is the inability to recognize potentially viable embryos before their replacement into the reproductive tract. Application of increasingly advanced new technology has allowed the field of embryo evaluation to evolve rapidly and dramatically over the past five years. Human Preimplantation Embryo Selection assembles the leaders in the field of assisted reproduction to discuss their visions of dealing with the topic of embryo selection in the light of the limitations involving the fragility of the early human embryo. The purpose of this book is to shed light on the ever-expanding techniques that are being employed and evaluated with regard to embryo selection. A comprehensive overview may guide the ART practitioner in choice of techniques and evaluation of benefits and drawbacks. This book will provide an up-to-date overview and reference source: an invaluable tool for assisted reproductive practice worldwide.

Human Genome Editing

Human Genome Editing
Author: National Academies of Sciences, Engineering, and Medicine,National Academy of Medicine,National Academy of Sciences,Committee on Human Gene Editing: Scientific, Medical, and Ethical Considerations
Publsiher: National Academies Press
Total Pages: 328
Release: 2017-08-13
ISBN 10: 0309452880
ISBN 13: 9780309452885
Language: EN, FR, DE, ES & NL

Human Genome Editing Book Review:

Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions. Human Genome Editing considers important questions about the human application of genome editing including: balancing potential benefits with unintended risks, governing the use of genome editing, incorporating societal values into clinical applications and policy decisions, and respecting the inevitable differences across nations and cultures that will shape how and whether to use these new technologies. This report proposes criteria for heritable germline editing, provides conclusions on the crucial need for public education and engagement, and presents 7 general principles for the governance of human genome editing.

Handbook of New Genetic Diagnostic Technologies in Reproductive Medicine

Handbook of New Genetic Diagnostic Technologies in Reproductive Medicine
Author: Carlos Simón,Carmen Rubio
Publsiher: CRC Press
Total Pages: 179
Release: 2017-12-14
ISBN 10: 1498763316
ISBN 13: 9781498763318
Language: EN, FR, DE, ES & NL

Handbook of New Genetic Diagnostic Technologies in Reproductive Medicine Book Review:

Different genetic diagnostic and treatment options are used worldwide to improve routine IVF procedures for the benefit of patients. This handbook updates the new genetic diagnostic technologies that have been translated to practice aiming to improve outcomes in the clinic and have a healthy baby at home. Chapters cover the use of genetic technologies in a personalized manner to unravel the possible genetic risks for the couple wishing to conceive, in terms of sperm, the embryo, the endometrium, miscarriage, and finally the fetus.

The End of Sex and the Future of Human Reproduction

The End of Sex and the Future of Human Reproduction
Author: Henry T. Greely
Publsiher: Harvard University Press
Total Pages: 381
Release: 2016-05-30
ISBN 10: 0674728963
ISBN 13: 9780674728967
Language: EN, FR, DE, ES & NL

The End of Sex and the Future of Human Reproduction Book Review:

Within twenty, maybe forty, years most people in developed countries will stop having sex for the purpose of reproduction. Instead, prospective parents will be told as much as they wish to know about the genetic makeup of dozens of embryos, and they will pick one or two for implantation, gestation, and birth. And it will be safe, lawful, and free. In this work of prophetic scholarship, Henry T. Greely explains the revolutionary biological technologies that make this future a seeming inevitability and sets out the deep ethical and legal challenges humanity faces as a result. “Readers looking for a more in-depth analysis of human genome modifications and reproductive technologies and their legal and ethical implications should strongly consider picking up Greely’s The End of Sex and the Future of Human Reproduction...[It has] the potential to empower readers to make informed decisions about the implementation of advancements in genetics technologies.” —Dov Greenbaum, Science “[Greely] provides an extraordinarily sophisticated analysis of the practical, political, legal, and ethical implications of the new world of human reproduction. His book is a model of highly informed, rigorous, thought-provoking speculation about an immensely important topic.” —Glenn C. Altschuler, Psychology Today

Reproductive Genetics

Reproductive Genetics
Author: Sean Kehoe,Lyn Chitty,Tessa Homfray
Publsiher: RCOG
Total Pages: 242
Release: 2009-11
ISBN 10: 1906985162
ISBN 13: 9781906985165
Language: EN, FR, DE, ES & NL

Reproductive Genetics Book Review:

This book presents the findings of the RCOG Study Group findings on genetics underlying reproductive function.

Reproductomics

Reproductomics
Author: José A. Horcajadas,Jaime Gosálvez
Publsiher: Academic Press
Total Pages: 425
Release: 2018-07-23
ISBN 10: 0128126760
ISBN 13: 9780128126769
Language: EN, FR, DE, ES & NL

Reproductomics Book Review:

Recent advances in genomic and omics analysis have triggered a revolution affecting nearly every field of medicine, including reproductive medicine, obstetrics, gynecology, andrology, and infertility treatment. Reproductomics: The –Omics Revolution and Its Impact on Human Reproductive Medicine demonstrates how various omics technologies are already aiding fertility specialists and clinicians in characterizing patients, counseling couples towards pregnancy success, informing embryo selection, and supporting many other positive outcomes. A diverse range of chapters from international experts examine the complex relationship between genomics, transcriptomics, proteomics, and metabolomics and their role in human reproduction, identifying molecular factors of clinical significance. With this book Editors Jaime Gosálvez and José A. Horcajadas have provided researchers and clinicians with a strong foundation for a new era of personalized reproductive medicine. Thoroughly discusses how genomics and other omics approaches aid clinicians in various areas of reproductive medicine Identifies specific genomic and molecular factors of translational value in treating infertility and analyzing patient data Features chapter contributions by leading international experts

Born and Made

Born and Made
Author: Sarah Franklin,Celia Roberts
Publsiher: Princeton University Press
Total Pages: 288
Release: 2006-10-30
ISBN 10: 1400835429
ISBN 13: 9781400835423
Language: EN, FR, DE, ES & NL

Born and Made Book Review:

Are new reproductive and genetic technologies racing ahead of a society that is unable to establish limits to their use? Have the "new genetics" outpaced our ability to control their future applications? This book examines the case of preimplantation genetic diagnosis (PGD), the procedure used to prevent serious genetic disease by embryo selection, and the so-called "designer baby" method. Using detailed empirical evidence, the authors show that far from being a runaway technology, the regulation of PGD over the past fifteen years provides an example of precaution and restraint, as well as continual adaptation to changing social circumstances. Through interviews, media and policy analysis, and participant observation at two PGD centers in the United Kingdom, Born and Made provides an in-depth sociological examination of the competing moral obligations that define the experience of PGD. Among the many novel findings of this pathbreaking ethnography of reproductive biomedicine is the prominence of uncertainty and ambivalence among PGD patients and professionals--a finding characteristic of the emerging "biosociety," in which scientific progress is inherently paradoxical and contradictory. In contrast to much of the speculative futurology that defines this field, Born and Made provides a timely and revealing case study of the on-the-ground decision-making that shapes technological assistance to human heredity.

Human Reproductive Genetics

Human Reproductive Genetics
Author: Juan A. Garcia-Velasco,Emre Seli
Publsiher: Academic Press
Total Pages: 340
Release: 2020-04-19
ISBN 10: 0128167491
ISBN 13: 9780128167496
Language: EN, FR, DE, ES & NL

Human Reproductive Genetics Book Review:

Human Reproductive Genetics: Emerging Technologies and Clinical Applications presents a great reference for clinicians and researchers in reproductive medicine. Part I includes a brief background of genetics and epigenetics, probability of disease, and the different techniques that are being used today for analysis and genetic counseling. Part II focuses on the analysis of the embryo, current controversies and future concepts. Part III comprises different clinical scenarios that clinicians frequently face in practice. The increasing amount of genetic tests available and the growing information that patients handle makes this section a relevant part of the fertility treatment discussion. Finally, Part IV concludes with the psychological aspects of genetic counseling and the role of counselor and bioethics in human reproduction. Provides an essential reference for clinicians involved in reproductive medicine Builds foundational knowledge on new genetic tests coming into the clinical scenario for physicians involved with patients Assembles critically evaluated chapters that cover basic concepts of genetics and epigenetics and the techniques involved, including preimplantation genetic testing, controversies, and more

Heritable Human Genome Editing

Heritable Human Genome Editing
Author: The Royal Society,National Academy of Sciences,National Academy of Medicine,International Commission on the Clinical Use of Human Germline Genome Editing
Publsiher: National Academies Press
Total Pages: 238
Release: 2021-01-16
ISBN 10: 0309671132
ISBN 13: 9780309671132
Language: EN, FR, DE, ES & NL

Heritable Human Genome Editing Book Review:

Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.

EmbryoGenetics

EmbryoGenetics
Author: Simón Carlos,Rubio Carmen
Publsiher: Unknown
Total Pages: 176
Release: 2021-07-07
ISBN 10: 9783036511528
ISBN 13: 3036511520
Language: EN, FR, DE, ES & NL

EmbryoGenetics Book Review:

Dear Colleagues, The science of human genetics has advanced at an exponential pace since the double-helix structure of DNA was identified in 1953. Within only 25 years of that discovery, the first gene was sequenced. Subsequent efforts in the span of a few decades have brought advanced next-generation sequencing and new tools for genome editing, allowing scientists to write and rewrite the code of life. We are now realizing that genetics represents yet another system of information technology that follows Moore's law, stating that computer processing power roughly doubles every two years. Importantly, with such rapid and sophisticated advancements, any tools or studies applicable to adult genetics can now also be applied to embryos. Genetic disorders affect 1% of live births and are responsible for 20% of pediatric hospitalizations and 20% of infant mortality. Many disorders are caused by recessive or X-linked genetic mutations carried by 85% of humans. Because assisted reproduction has armed us with technologies like in vitro fertilization that provide access to human embryos, we began to screen some genetic diseases simply by selecting sex. The first live births following preimplantation genetic testing (PGT) to identify sex in X-linked disease were reported by Alan Handyside in 1990. This groundbreaking work used the identification of male embryos and selective transfer of unaffected normal or carrier females as proof-of-concept to avoid genetic diseases, paving the way to extend the concept to PGT for monogenic diseases (PGT-M), including Mendelian single-gene defects (autosomal dominant/recessive, X-linked dominant/recessive), severe childhood lethality or early-onset disease, cancer predisposition, and HLA typing for histocompatible cord-blood stem cells' transplantation. Later, we moved onto the identification and selection of euploid embryos by analysing all 23 pairs of chromosomes in 4-8 cells from the trophectoderm, called PGT for aneuploidy (PGT-A). PGT-A currently leverages next-generation sequencing technologies to uncover meiotic- and mitotic-origin aneuploidies affecting whole chromosomes, as well as duplications/deletions of small chromosome regions. A step forward was the use of structural chromosome rearrangements (PGT-SR) to identify Robertsonian and reciprocal translocations, inversions, and balanced vs. unbalanced rearrangements. Another advancement came with PGT for polygenic risk scoring (PGT-P). This technique takes us from learning how to read simple words to starting to understand poetry (i.e., evolving from PGT-M/A/SR to PGT-P for multifactorial, polygenic risk prediction). Common multifactorial diseases like diabetes, coronary heart disease, and cancer are caused by a combination of environmental, lifestyle, and genetic factors; risk scores are now being generated to predict the likelihood of such complex, later-life diseases in embryos. Moreover, we are moving from embryo selection to intervention because the genetic code is not only readable, but also re-writeable. Indeed, gene editing is now possible using tools like CRISPR/Cas9, which are applicable to all species, including human embryos. In this Special Issue, we invite reviews, primers, and original research papers that contribute to our understanding of human embryo genetics. Specifically, we would like to compile the current knowledge in PGT for monogenic diseases (PGT-M), PGT for aneuploidy (PGT-A) including mosaicism, PGT for polygenic risk scoring (PGT-P), and gene editing in human embryos. Manuscripts can target both basic science as well as the clinical impact of embryogenetics in reproductive medicine, maternal-fetal medicine, and pediatrics. We look forward to your submissions

Science and Babies

Science and Babies
Author: Institute of Medicine,Suzanne Wymelenberg
Publsiher: National Academies Press
Total Pages: 184
Release: 1990-02-01
ISBN 10: 0309041368
ISBN 13: 9780309041362
Language: EN, FR, DE, ES & NL

Science and Babies Book Review:

By all indicators, the reproductive health of Americans has been deteriorating since 1980. Our nation is troubled by rates of teen pregnancies and newborn deaths that are worse than almost all others in the Western world. Science and Babies is a straightforward presentation of the major reproductive issues we face that suggests answers for the public. The book discusses how the clash of opinions on sex and family planning prevents us from making a national commitment to reproductive health; why people in the United States have fewer contraceptive choices than those in many other countries; what we need to do to improve social and medical services for teens and people living in poverty; how couples should "shop" for a fertility service and make consumer-wise decisions; and what we can expect in the future--featuring interesting accounts of potential scientific advances.

Preimplantation Genetic Testing

Preimplantation Genetic Testing
Author: Darren K. Griffin,Gary L. Harton
Publsiher: CRC Press
Total Pages: 163
Release: 2020-06-19
ISBN 10: 0429820305
ISBN 13: 9780429820304
Language: EN, FR, DE, ES & NL

Preimplantation Genetic Testing Book Review:

Preimplantation genetic testing (PGT) is now well established as a valuable treatment option for patients wishing to start or continue a family, for a range of indications from advanced maternal age to high risk of transmitting inherited disease. This text brings together contemporary thinking from international opinion leaders and will be an invaluable guide for practitioners in Reproductive Medicine wishing to keep pace with the latest developments and clinical data.

In Vitro Fertilization

In Vitro Fertilization
Author: Kay Elder,Brian Dale
Publsiher: Cambridge University Press
Total Pages: 135
Release: 2010-12-02
ISBN 10: 1139492853
ISBN 13: 9781139492850
Language: EN, FR, DE, ES & NL

In Vitro Fertilization Book Review:

This fully updated new edition of a successful and popular practical guide is an indispensable account of modern in-vitro fertilization practice. Initial chapters cover theoretical aspects of gametogenesis and embryo development at the cellular and molecular level, while the latter half of the book describes the requisites for a successful IVF laboratory and the basic technologies in ART. Advanced techniques, including pre-implantation genetic diagnosis, vitrification and stem-cell technology, are comprehensively covered, providing up-to-date analyses of these groundbreaking technologies. This edition includes: • New practical techniques, including preservation of fertility for cancer patients, stem-cell biology/technology, vitrification and in-vitro maturation • A 'refresher' study review of fundamental principles of cell and molecular biology • The latest information available from animal and human research in reproductive biology Packed with a wealth of practical and scientific detail, this is a must for all IVF practitioners.

Regulating Pre implantation Genetic Diagnosis

Regulating Pre implantation Genetic Diagnosis
Author: Sheila McLean,Sarah Elliston
Publsiher: Routledge
Total Pages: 250
Release: 2012
ISBN 10: 041568644X
ISBN 13: 9780415686440
Language: EN, FR, DE, ES & NL

Regulating Pre implantation Genetic Diagnosis Book Review:

The successful achievement of pregnancies following pre-implantation genetic diagnosis (PGD) was first reported in April 1990. The technology is often used for patients who are at substantial risk of conceiving a pregnancy affected by a known genetic disorder, however from this technology other more controversial uses have arisen such as HLA typing to save the life of a sibling, gender selection for social reasons, the prevention of late onset diseases, or the prevention of diseases which may be genetically predisposed to developing such as breast cancer. The technology surrounding PGD is constantly developing, giving rise to new and unexpected consequences that create fresh ethical and legal dilemmas. Featuring internationally recognized experts in the field, this book critically explores the regulation of PGD and the broader legal and ethical issues associated with it. It looks at the regulatory situation in a number of jurisdictions including New Zealand, Australia and the United Kingdom, but it also explores a number of themes of wide significance including a historical consideration of PGD and its part in the creation of the "genetic embryo" as a political tool, the over regulation of PGD and the ethical difficulties in handling additional unexpected medical information yielded by new technologies. This book will be of particular interest to academics and students of law, medicine and ethics.

Expanding Horizons in Bioethics

Expanding Horizons in Bioethics
Author: A.W. Galston,Christiana Z. Peppard
Publsiher: Springer Science & Business Media
Total Pages: 255
Release: 2005-12-05
ISBN 10: 9781402030628
ISBN 13: 1402030622
Language: EN, FR, DE, ES & NL

Expanding Horizons in Bioethics Book Review:

Like its predecessor, New Dimensions in Bioethics, this volume developed out of a series of lectures at Yale University’s Institution for Social and Policy Studies. Each speaker in the Bioethics & Public Policy Seminar Series was invited because of her or his expertise in a given area of bioethics. Each of the more successful participants was invited to contribute a manuscript for publication. The essays are bound together by the application of an ethical analysis to scientific questions, and by consideration of policy implications. At its inception, bioethics was virtually synonymous with medical ethics. As the field grew and attracted new practitioners, it became clear that other applications of this new subject required extension of its scope. For example, environmental ethics, propelled by such authors as Aldo Leopold and Rachel Carson, quickly developed a vigorous literature of its own. More recently, developments in the analysis of the human genome, the enticing medical possibilities offered by the therapeutic use of stem cells, the complexities surrounding the cloning of animals and possibly humans and the development of transgenic agricultural crops have given new impetus to the expansion of traditional bioethical horizons. Bioethics must now adjust to these new realities, for it is clear that public interest in the field is growing as these new challenges appear.

Human Gametes and Preimplantation Embryos

Human Gametes and Preimplantation Embryos
Author: David K. Gardner,Denny Sakkas,Emre Seli,Dagan Wells
Publsiher: Springer Science & Business Media
Total Pages: 306
Release: 2013-05-27
ISBN 10: 1461466512
ISBN 13: 9781461466512
Language: EN, FR, DE, ES & NL

Human Gametes and Preimplantation Embryos Book Review:

In recent years, the advancing science and increasing availability of assisted reproduction have given new hope to infertile couples. However, the use of IVF and ART has also led to marked increases in the number of multiple-infant live births. This poses a public health concern, as these neonates have a higher rate of pre-term delivery, compromising their survival chances and increasing their risk of lifelong disability. By optimizing the selection of gametes and embryos with high probabilities of implantation, it is possible to reduce the number of embryos transferred and, by extension, the number of high-risk multiple gestations, while maintaining or increasing pregnancy rates. Human Gametes and Preimplantation Embryos: Assessment and Diagnosis provides a broad yet concise overview of established and developing methodologies for assessment of gamete and embryo viability in assisted reproduction. This book elucidates the best practices for precisely selecting viable specimens based on morphology and cleavage rate and covers the spectrum of emerging adjunctive technologies for predicting reproductive potential. The authors present their extensive knowledge of “omics” approaches (genomics, transcriptomics, proteomics, and metabolomics), with unbiased delineation of the associated advantages and potential pitfalls. This valuable clinical resource is well suited to infertility specialists, Ob/Gyn physicians, IVF laboratory technicians, and researchers in the fields of embryology and reproductive medicine.